Podcasts about clinical virology

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-400 Overview: The FDA recently approved primary human papillomavirus (HPV) self-collection for cervical cancer screening in a healthcare setting. Join us as we explore how to counsel patients on this less invasive method and find out what's on the horizon for at-home collection kits. Episode resource links: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P160037 Journal of Clinical Virology, 2020-06-01, Volume 127, Article 104375, Copyright © 2020 Elsevier B.V.  JAMA. 2023;330(20):1971-1981. doi:10.1001/jama.2023.21471 Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-400 Overview: The FDA recently approved primary human papillomavirus (HPV) self-collection for cervical cancer screening in a healthcare setting. Join us as we explore how to counsel patients on this less invasive method and find out what's on the horizon for at-home collection kits. Episode resource links: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P160037 Journal of Clinical Virology, 2020-06-01, Volume 127, Article 104375, Copyright © 2020 Elsevier B.V.  JAMA. 2023;330(20):1971-1981. doi:10.1001/jama.2023.21471 Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Today On Medical Grounds, we will be speaking with Dr. Matt Binnicker, Director of Clinical Virology at Mayo Clinic about bird flu. Highly pathogenic avian influenza viruses have been detected in wild aquatic birds, commercial poultry, and backyard flocks beginning around January 2022 in the U.S. To date, over 100,700,000 birds have been affected. Recently, cases of bird flu have been detected in 171 dairy herds, and there have been 13 reported human cases in the U.S. There have also been human cases reported overseas. Dr. Binnicker joins us to share his knowledge of bird flu, vaccines, and whether we need to be concerned about a new pandemic.(00:09) Introduction to Dr. Binnicker(01:12) Introduction to bird flu(03:57) Morphology and rapid mutation of avian influenza(06:47) The problem with pigs(09:23) Human concerns(11:11) Transmission through raw milk(13:33) Developing a lab test for H5 avian influenza(17:15) H5 vaccinations and vaccine availability(20:33) Role of climate change in a future avian influenza pandemic(22:27) What keeps Dr. Binnicker up at nightVisit us at OnMedicalGrounds.com for more podcasts or download our app! You can subscribe through your podcast platform, our website, or follow us on social media for podcast updates and medical news. Some of our podcasts offer FREE CME/CE credits.LinkTreeTwitterLinkedInInstagram

From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control. Hosts: Vincent Racaniello and Heli Harvala Guest: Eeva Broberg Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) European Centre for Disease Prevention and Control Emerging echovirus 30 in Europe (Emerg Inf Dis) RSV surveillance (Eur Resp J) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

This episode is part two of the great emerging viruses talk with Dr. Ryan Relich and Benjamin Pinsky. They talk over diagnostic tests for viruses, challenges with test development, and they share their thoughts on viruses and outbreaks. Link to the National Academies Arbovirus workshop: https://www.nationalacademies.org/our-work/mitigating-arboviral-threats-and-strengthening-public-health-preparedness-a-workshopLink to the Pan American Society for Clinical Virology: https://www.pascv.org/default.aspx

From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Environ) SARS-CoV-2 in mink and other animals (Transbound Emerg Dis) Mpox in Netherlands (EuroSurveill) Divergent SARS-CoV-2 in immunocompromised patient (Emerg Inf Dis) Accelerated SARS-CoV-2 evolution in deer (Nat Commun) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Dr. Elli Theel and Dr. Alex McAdam discuss recent viral outbreaks with expert virologists. Recorded before a live audience at ASM Microbe 2023. Topics: What are the recent epidemiologic and diagnostic findings with Mpox?  What are the reservoirs for influenza A H5N1 and how is it transmitted to humans? Why was there such a large number of cases of human metapneumovirus this past respiratory virus season? Guests: Dr. Ben Pinsky, Director of the Clinical Virology laboratory and Professor of Pathology and Medicine at Stanford Health Care and the Stanford University School of Medicine Dr. Ryan Relich, Director of Clinical Microbiology and the Special Pathogens Unit laboratory at IU Health and Eskenazi Health and an Associate Professor of Clinical Pathology and Laboratory Medicine at the Indiana University School of Medicine This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter via @JClinMicro

In this episode of “Lab Medicine Rounds,” Justin Kreuter, M.D., sits down with Matthew Binnicker, Ph.D., Director of Clinical Virology and Vice Chair of Practice in the Department of Laboratory Medicine and Pathology a Mayo Clinic, to talk about working and leading through uncertainty.Timestamps:0:00 Intro01:22 Why is working with uncertainty an important skill for us to cultivate?03:13 What are ways to keep grounded when navigating uncertainty?06:17 When you are not in a crisis moment, when it's not an ambiguous time, how do you behave in a way that further cultivates this idea that you are a leader?08:22 How could we help our colleagues who are struggling with uncertainty?10:12 How can we help people with a fixed mindset as opposed to a growth mindset move from seeing negative feedback as uncomfortable, how can we help them see the growth and opportunity in front of them?12:09 I'm curious if you could share with our listeners a story of how uncertainty has surprised you most?15:35 Outro

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host: Vincent Racaniello Guest: Richard Knight Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National CJD Research and Surveillance Unit Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) Creutzfeldt-Jakob disease (Adv Exp Med Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2. Hosts: Vincent Racaniello Guest: Emma Thomson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Thomson laboratory Emma on TWiV 188 and TWiV 341 AAV2-associated pediatric hepatitis (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

We are just back from the Molecular Virology Workshop in West Palm Beach. This is a terrific meeting that is organized by the Pan-American Society for Clinical Virology or PASCV. The workshop immediately precedes the Clinical Virology Symposium that ASM organizes and many of us like to attend both. Today we'll be talking about some of the high points of the Molecular Virology Workshop, with two members of the organizing committee from PASCV. Guests: Dr. Erin Graf, Director, Clinical Microbiology at Mayo Clinic in Phoenix Arizona. Dr. Stephanie Mitchell, Director of Medical Affairs at Cepheid. This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Links: On-demand sessions from PASCV https://www.pascv.org/page/MVW Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter via @JClinMicro

This episode is shared from Mayo Clinic Q&A and was recorded in January 2022 Guest: Matthew J. Binnicker, Ph.D. (@DrMattBinnicker) Host: Halena M. Gazelka, M.D. (@hmgazelkamd) Testing for COVID-19 is a part of the strategy to end the pandemic. But understanding testing — different types of tests and how and when to use them — can be confusing. Lab-run polymerase chain reaction, or PCR, tests and at-home antigen tests each have a role. "PCR tests are really sensitive, meaning we can detect really low levels of the virus in a sample," explains Dr. Matthew Binnicker, director of Clinical Virology at Mayo Clinic. "They're very specific, meaning we shouldn't get many false positive results with PCR tests." At-home antigen tests use a nasal swab and can produce results in 15 minutes, but they also have an increased chance of false-negative results, depending on when you test.  "At-home rapid antigen tests look for a viral protein in the patient sample," says Dr. Binnicker. "So they're quick and easy, but they also have some important limitations." So if you're worried you might have COVID-19, what test should you take and when?  On the Q&A podcast, Dr. Binnicker walks through various scenarios and makes testing recommendations for what to do if: You think you've been exposed but I don't have symptoms. You have symptoms of COVID-19. You had COVID-19 and want to know if you're “in the clear” to return to work, school or activities.

Testing for COVID-19 is a part of the strategy to end the pandemic. But understanding testing — different types of tests and how and when to use them — can be confusing. Lab-run polymerase chain reaction, or PCR, tests and at-home antigen tests each have a role."PCR tests are really sensitive, meaning we can detect really low levels of the virus in a sample," explains Dr. Matthew Binnicker, director of Clinical Virology at Mayo Clinic. "They're very specific, meaning we shouldn't get many false positive results with PCR tests."At-home antigen tests use a nasal swab and can produce results in 15 minutes, but they also have an increased chance of false-negative results, depending on when you test. "At-home rapid antigen tests look for a viral protein in the patient sample," says Dr. Binnicker. "So they're quick and easy, but they also have some important limitations."So if you're worried you might have COVID-19, what test should you take and when? On the Q&A podcast, Dr. Binnicker walks through various scenarios and makes testing recommendations for what to do if: You think you've been exposed but I don't have symptoms. You have symptoms of COVID-19. You had COVID-19 and want to know if you're “in the clear” to return to work, school or activities.

From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one. Host: Vincent Racaniello Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Simian adenoviruses as vaccine vectors (Future Viral) Early SARS-CoV-2 spread in Lombardy (Nat Comm) SARS-CoV-2 seroprevalence in Denmark (Clin Micro Inf) SARS-CoV-2 testing in an academic center (Nat Biotech) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one. Host: Vincent Racaniello Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Simian adenoviruses as vaccine vectors (Future Viral) Early SARS-CoV-2 spread in Lombardy (Nat Comm) SARS-CoV-2 seroprevalence in Denmark (Clin Micro Inf) SARS-CoV-2 testing in an academic center (Nat Biotech) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

How can we determine whether someone who has COVID-19 can transmit the virus to other people? Tests in routine clinical use, such as reverse-transcription polymerase chain reaction and antigen tests, are designed to determine whether SARS-CoV-2 is present or not, but many people have proposed that these tests be used to determine whether a patient is infectious. Furthermore, tests for SARS-CoV-2 that are not routinely used in clinical laboratories, such as viral culture and detection of sub-genomic viral RNAs, have also been discussed as indicators of infectivity. But how accurate are any of these tests for determining whether someone is infectious? Guest: Dr. Matthew Binnicker, Director of Clinical Virology and Professor of Laboratory Medicine and Pathology at Mayo Clinic. Twitter: @DrMattBinnicker Links: Can Testing Predict SARS-CoV-2 Infectivity? The Potential for Certain Methods to be a Surrogate for Replication-Competent Virus https://journals.asm.org/doi/10.1128/JCM.00469-21 Visit https://asm.org/jcm to read articles and/or submit a manuscript. Follow JCM on Twitter via https://twitter.com/JClinMicro Subscribe to ASM's YouTube channel at https://goo.gl/mOVHlK

In this episode, drug policy researcher Alan Cassels and I take a deep look into some less than desirable tactics of the pharmaceutical and health care industries. Alan has been investigating and reporting on nefarious industry strategies for more than 2 decades, and his books Selling Sickness and Seeking Sickness expose the dirty underbelly that some corporations and leaders would rather you did not know about. If you have been satisfied with the mainstream Covid-19 narrative, this episode might be a bit disruptive. If you have been questioning it, then you might find some answers here, as well as more questions. We discuss the limitations of PCR testing, the predominant testing model for determining Covid cases; the new Pfizer vaccine and the misleading propaganda related to it; Covid case numbers; and so-called protective measures. I have also published this episode on Pacific Rim College Radio, but I have included my special post-interview perspective at the end of this conversation? Going beyond Covid-19, Alan and I also explore questionable pharmaceutical selling strategies; conditions such as high cholesterol, osteoporosis, and hypertension; the industry of influenza; and drug safety advisories. If episode 28 with holistic pharmacist RoseMarie Pierce opened up a few uncertainties for you about the motivations of the pharmaceutical industry, this episode is going to rip the lid right off. I hope you are stirred by this episode of Pacific Rim College Radio with Alan Cassels. Episode Links: Selling Sickness by Alan Cassels Seeking Sicknessby Alan Cassels Twitter @akecassels Pfizer CEO sells stock Article on PCR Test British Columbia Covid-19 Dashboard Order of Provincial Health Officer in BC Hospitals in BC Journal of Clinical Virology article on PCR test amplification in Canada Eurosurveillance journal article on PCR test amplification Article on infectiousness and Ct values in European Journal of Clinical Microbiology and Infectious Diseases Anchor Point Links: Men's Retreats at Anchor Point Expeditions

In this episode, drug policy researcher Alan Cassels and I take a deep look into some less than desirable tactics of the pharmaceutical and health care industries. Alan has been investigating and reporting on nefarious industry strategies for more than 2 decades, and his books Selling Sickness and Seeking Sickness expose the dirty underbelly that some corporations and leaders would rather you did not know about. If you have been satisfied with the mainstream Covid-19 narrative, this episode might be a bit disruptive. If you have been questioning it, then you might find some answers here, as well as more questions. We discuss the limitations of PCR testing, the predominant testing model for determining Covid cases; the new Pfizer vaccine and the misleading propaganda related to it; Covid case numbers; and so-called protective measures. Going beyond Covid-19, Alan and I also explore questionable pharmaceutical selling strategies; conditions such as high cholesterol, osteoporosis, and hypertension; the industry of influenza; and drug safety advisories. If episode 28 with holistic pharmacist RoseMarie Pierce opened up a few uncertainties for you about the motivations of the pharmaceutical industry, this episode is going to rip the lid right off. I hope you are stirred by this episode of Pacific Rim College Radio with Alan Cassels. Episode Links: Selling Sickness by Alan Cassels Seeking Sickness by Alan Cassels Twitter @akecassels Pfizer CEO sells stock Article on PCR Test British Columbia Covid-19 Dashboard Hospitals in BC Journal of Clinical Virology article on PCR test amplification in Canada Eurosurveillance journal article on PCR test amplification Article on infectiousness and Ct values in European Journal of Clinical Microbiology and Infectious Diseases Learning Links: School of Holistic Nutrition at PRC School of Western Herbal Medicine at PRC PRC Radio Episode 28 with RoseMarie Pierce Holistic Nutrition courses at PRCOnline. Sign up for the PRCO newsletter and get 40% off during the on November 24th launch our new Food-Drug-Herb-Nutrients Interactions and Depletions course

Join us for the second episode of UCL's new podcast, ‘Coronavirus: The Whole Story' with Vivienne Parry.This week we're exploring how we can track the spread of the virus. With special guests Professor Andrew Hayward, Director of the UCL Institute of Epidemiology and Health Care and Dr Eleni Nastouli, Assistant Professor at the Institute of Child Health and Clinical Lead of the Department of Clinical Virology at UCLH.For more info and transcripts, visit www.ucl.ac.uk/ucl-minds/podcasts/coronavirus See acast.com/privacy for privacy and opt-out information.

Welcome to our seventh webinar and journal club reviewing recent research and featuring COVID-19 updates, hosted by the University of Manchester, Manchester Royal Infirmary and Royal College of Emergency Medicine in collaboration with St Emlyn's.   The live event took place on Tuesday 26th May. Today's panel will be hosted by Rick Body The panel includes Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynard (NIHR Clinical Research Fellow), Dr Anisa Jafar, Prof Pam Vallely (Professor of Medical Virology), Ellie Hothershall (Consultant in Public Health), Prof Simon Carley and special guest Kelly Ann Janssens (Emergency Physician in Ireland) to discuss five papers about COVID-19 infection. This will be the last weekly journal club, but we will be back with more EBM goodness very soon. Do let us know what you like to be included at stemlyns@gmail.com References Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the Treatment of Covid-19 — Preliminary Report. N Engl J Med. Published online May 22, 2020. doi:10.1056/nejmoa2007764 Mehra MR, Desai SS, Ruschitzka F, Patel AN. Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. The Lancet. Published online May 2020. doi:10.1016/s0140-6736(20)31180-6 Gray N, Calleja D, Wimbush A, et al. “No test is better than a bad test”: Impact of diagnostic uncertainty in mass testing on the spread of Covid-19. Published online April 22, 2020. doi:10.1101/2020.04.16.20067884 Peyrony O, Marbeuf-Gueye C, Truong V, et al. Accuracy of Emergency Department clinical findings for diagnostic of coronavirus disease-2019. Annals of Emergency Medicine. Published online May 2020. doi:10.1016/j.annemergmed.2020.05.022 Ludvigsson JF. Children are unlikely to be the main drivers of the COVID‐19 pandemic – a systematic review. Acta Paediatr. Published online May 19, 2020. doi:10.1111/apa.15371 Podcast edited from a live webinar by Iazzy Carley  

Welcome to our sixth COVID-19 Journal Club Podcast.   The panel was hosted by Rick Body and included Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynard (NIHR Clinical Research Fellow), Dr Anisa Jafar, Prof Pam Vallely (Professor of Medical Virology), Prof Simon Carley and special guest Liz Crowe (Advanced Clinician Social Worker and PhD candidate in health staff wellbeing in Brisbane) to discuss four papers about COVID-19 infection. We were especially pleased to welcome Liz this week, which enabled us to focus on the important topics of grief, loss and communication during the COVID-19 pandemic. References 1. Williamson E, Walker AJ, et al. OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients. May 2020. doi:10.1101/2020.05.06.20092999 2. Menni C, Valdes AM, Freidin MB, et al. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med. May 2020. 3. Liu Y, Ning Z, Chen Y, et al. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. April 2020. doi:10.1038/s41586-020-2271-3 4. Selman LE, Chao D, Sowden R, Marshall S, Chamberlain C, Koffman J. Bereavement support on the frontline of COVID-19: Recommendations for hospital clinicians. Journal of Pain and Symptom Management. May 2020. doi:10.1016/j.jpainsymman.2020.04.024   Podcast edited from a live webinar by Izzy Carley

Welcome to our fifth webinar and journal club reviewing recent research and featuring COVID-19 updates, hosted by the University of Manchester, Manchester Royal Infirmary and Royal College of Emergency Medicine in collaboration with St Emlyn's. The live event took place on Tuesday 12th May at 11.00am BST (10.00am GMT).  The COVID-19 Journal Club Panel Today's panel was hosted by Rick Body The panel includes Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynard (NIHR Clinical Research Fellow), Prof Dan Horner, Dr Anisa Jafar, Prof Pam Vallely (Professor of Medical Virology), Prof Simon Carley and special guest Lauren Westafer (Attending in Emergency Medicine and Co-Creator of the Foamcast blog and podcast) and Ellie Hothershall (head of undergraduate medicine at the University of Dundee and an expert in Public Health) to discuss six papers about COVID-19 infection. 1. Lai S, Ruktanonchai NW, Zhou L, et al. Effect of non-pharmaceutical interventions to contain COVID-19 in China. Nature. May 2020. doi:10.1038/s41586-020-2293-x 2. Paranjpe I, Fuster V, Lala A, et al. Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19. Journal of the American College of Cardiology. May 2020. doi:10.1016/j.jacc.2020.05.001 3. Thanh L, Andreadakis Z, Kumar A, et al. The COVID-19 vaccine development landscape. Nat Rev Drug Discov. 2020;19(5):305-306. doi:10.1038/d41573-020-00073-5 4. Bryan A, Pepper G, Wener MH, et al. Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence in Boise, Idaho. J Clin Microbiol. May 2020. doi:10.1128/jcm.00941-20 5. Treibel TA, Manisty C, Burton M, et al. COVID-19: PCR screening of asymptomatic health-care workers at London hospital. The Lancet. May 2020. doi:10.1016/s0140-6736(20)31100-4 6. Altmann S, Milsom L, Zillessen H, et al. Acceptability of app-based contact tracing for COVID-19: Cross-country survey evidence. May 2020. doi:10.1101/2020.05.05.20091587   Podcast edited from a live webinar by Izzy Carley

Welcome to our fourth webinar and journal club reviewing recent research and featuring COVID-19 updates, hosted by the University of Manchester, Manchester Royal Infirmary and Royal College of Emergency Medicine in collaboration with St Emlyn's.   The live event tool place on Tuesday 5th May at 11.30am BST (10.30am GMT).    The panel was again be hosted by Rick Body The panel includes Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynard (NIHR Clinical Research Fellow), Dr Anisa Jafar (Academic Clinical Lecturer), Prof Pam Vallely (Professor of Medical Virology), Prof Simon Carley and special guest Justin Morgenstern to discuss six papers about COVID-19 infection.   There will be another COVID 19 Journal Club next week (Tuesday 12th May at 11am).   References 1. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. Published online April 15, 2020. doi:10.1038/s41591-020-0869-5   2. Bahl P, Doolan C, de Silva C, Chughtai AA, Bourouiba L, MacIntyre CR. Airborne or Droplet Precautions for Health Workers Treating Coronavirus Disease 2019? The Journal of Infectious Diseases. Published online April 16, 2020. doi:10.1093/infdis/jiaa189.   3. Wang Y, Zhang D, Du G, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. The Lancet. Published online April 2020. doi:10.1016/s0140-6736(20)31022-9   4. Rajendran K, Narayanasamy K, Rangarajan J, Rathinam J, Natarajan M, Ramachandran A. Convalescent plasma transfusion for the treatment of COVID‐19: Systematic review. J Med Virol. Published online May 2020. doi:10.1002/jmv.25961   5. Tedeschi S, Giannella M, Bartoletti M, et al. Clinical impact of renin-angiotensin system inhibitors on in-hospital mortality of patients with hypertension hospitalized for COVID-19. Clinical Infectious Diseases. Published online April 27, 2020. doi:10.1093/cid/ciaa492   6. Docherty AB, Harrison EM, Green CA, et al. Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol. Published online April 28, 2020. doi:10.1101/2020.04.23.20076042   Podcast edited from a live webinar by Izzy Carley 

Welcome to our third webinar and journal club reviewing recent research and featuring COVID-19 updates, hosted by the University of Manchester, Manchester Royal Infirmary and Royal College of Emergency Medicine in collaboration with St Emlyn's. The live event took place on Tuesday 28th April at 11am BST (10am GMT). The panel was hosted by Rick Body The panel includes Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynard (NIHR Clinical Research Fellow), Dr Dan Horner (RCEM Professor), Prof Pam Vallely (Professor of Medical Virology), Salim Rezaie (Emergency Physician and Founder of REBEL EM) and Prof Simon Carley (you know him…) to discuss five papers about COVID-19 infection. There will be another COVID 19 Journal Club next week (Tuesday 5th May at 11am). Edited by Izzy Carley and Iain Beardsell References Helms J. High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Medicine. April 2020:1-21. https://www.esicm.org/wp-content/uploads/2020/04/863_author_proof.pdf. Caputo ND, Strayer RJ, Levitan R. Early Self‐Proning in Awake, Non‐intubated Patients in the Emergency Department: A Single ED's Experience during the COVID‐19 Pandemic. Acad Emerg Med. April 2020. doi:10.1111/acem.13994 Garcia FP, Perez Tanoira R, Romanyk Cabrera JP, Arroyo Serrano T, Gomez Herruz P, Cuadros Gonzalez J. Rapid diagnosis of SARS-CoV-2 infection by detecting IgG and IgM antibodies with an immunochromatographic device: a prospective single-center study. April 2020. doi:10.1101/2020.04.11.20062158 Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. April 2020. doi:10.1001/jama.2020.6775 Metzler B, Siostrzonek P, Binder R, Bauer A, Reinstadler S. Decline of acute coronary syndrome admissions in Austria since the outbreak of COVID-19: the pandemic response causes cardiac collateral damage. Eur Heart J. April 2020. doi:10.1093/eurheartj/ehaa314

Welcome to our second webinar on recent research about COVID-19, hosted by the University of Manchester, Manchester Royal Infirmary and Royal College of Emergency Medicine in collaboration with St Emlyn's. The panel was hosted by Rick Body. The panel includes Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynard (NIHR Clinical Research Fellow), Prof Pam Vallely (Professor of Medical Virology), Dr Anisa Jafar (Academic Clinical Lecturer), Dr Casey Parker and Prof Simon Carley (you know him…) to discuss six papers about COVID-19 infection. The live event took place on Tuesday 21st April 2020 References:  Paper 1 (00:00) Tang W, Cao Z, Han M, et al. Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial. April 2020. doi:10.1101/2020.04.10.20060558 Paper 2 (12:09) Bendavid E, Mulaney B, Sood N, et al. COVID-19 Antibody Seroprevalence in Santa Clara County, California. April 2020. doi:10.1101/2020.04.14.20062463   Paper 3 (16:40) Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. April 2020. doi:10.1038/s41586-020-2196-x   Paper 4 (23:33) Favas C. Guidance for the Prevention of COVID-19 Infections among High-Risk Individuals in Camps and Camp-like Settings. London School of Hygiene and Tropical Medicine; 2020:1-15. https://www.lshtm.ac.uk/sites/default/files/2020-04/Guidance%20for%20the%20prevention%20of%20COVID-19%20infections%20among%20high-risk%20individuals%20in%20camps%20and%20camp-like%20settings.pdf. Accessed April 21, 2020.   Paper 5 (30:30) Zeng J-H, Liu Y-X, Yuan J, et al. First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection. April 2020. doi:10.1007/s15010-020-01424-5   Paper 6 (35:02) Caruso D, Zerunian M, Polici M, et al. Chest CT Features of COVID-19 in Rome, Italy. Radiology. April 2020:201237. doi:10.1148/radiol.2020201237   Podcast edited by Izzy Carley and Iain Beardsell

Professor Rick Body is joined by Prof Paul Klapper (Professor of Clinical Virology), Dr Charlie Reynolds (NIHR Clinical Research Fellow), Prof Pam Vallely (Professor of Medical Virology), Dr Anisa Jafar (Academic Clinical Lecturer) and Prof Simon Carley (you know him...) to discuss six papers about COVID-19 infection.  03:10 - Paper 1 – Guan et al. Clinical characteristics of Coronavirus disease 2019 in China. NEJM Feb 28 2020 https://www.nejm.org/doi/full/10.1056/NEJMoa2002032 16:54 Paper 2 – Zou et al. Single Cell RNA-SEQ Data Analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-NCOV infection. Frontiers of Medicine. Mar 12 2020. https://link.springer.com/content/pdf/10.1007/s11684-020-0754-0.pdf 21:43 Paper 3 – Gautret et al. Hydroxychloroquine and azithromycin treatment of COVID-19: Results of an open-label non-randomised clinical trial. International Journal of Antimicrobial Agents. 20 Mar 2020 https://www.sciencedirect.com/science/article/pii/S0924857920300996?via%3Dihub 25:25 Paper 4 – Cao et al. A trial of Lopinavir-Ritonavir in adults hospitalized with severe COVID-19. NEJM Mar 18 2020 https://www.nejm.org/doi/pdf/10.1056/NEJMoa2001282 29:35 Paper 5 – Cui et al. Prevalence of venous thromboembolism in patients with severe Coronavirus pneumonia. Journal of Thrombosis and Haemostasis. Apr 9 2020 doi:10.1111/jth.14830 https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.14830 34:14 Paper 6 – Lynarts et al. Prediction models for diagnosis and prognosis of COVID-19 infection: systematic review and critical appraisal. BMJ. Apr 7 2020 BMJ 2020;369:m1328 https://www.bmj.com/content/bmj/369/bmj.m1328.full.pdf

Testing for COVID-19 is a part of the strategy to end the pandemic. But understanding testing — different types of tests and how and when to use them — can be confusing. Lab-run polymerase chain reaction, or PCR, tests and at-home antigen tests each have a role."PCR tests are really sensitive, meaning we can detect really low levels of the virus in a sample," explains Dr. Matthew Binnicker, director of Clinical Virology at Mayo Clinic. "They're very specific, meaning we shouldn't get many false positive results with PCR tests."At-home antigen tests use a nasal swab and can produce results in 15 minutes, but they also have an increased chance of false-negative results, depending on when you test. "At-home rapid antigen tests look for a viral protein in the patient sample," says Dr. Binnicker. "So they're quick and easy, but they also have some important limitations."So if you're worried you might have COVID-19, what test should you take and when? On the Q&A podcast, Dr. Binnicker walks through various scenarios and makes testing recommendations for what to do if: You think you've been exposed but I don't have symptoms. You have symptoms of COVID-19. You had COVID-19 and want to know if you're “in the clear” to return to work, school or activities. Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy