Podcasts about leptospira

Dr. Richard L. Oehler, Professor of Medicine at the Division of Infectious Diseases, Morsani College of Medicine, reviews two important clinical syndromes caused by Spirochetes. Dr Oehler begins by presenting an actual clinical case of Leptospirosis in a returning traveller from the Caribbean. He then discusses the epidemiology of Leptospira, a widespread zoonotic pathogen that favors temperate and topical climates worldwide. He then relates the life cycle, means of transmission, microbiology, clinical manifestations, and most relevant diagnostic studies. He concludes the leptospirosis section by discussing treatment and prevention. The second case he discusses is a febrile illness in a returning traveler from Jordan. Dr. Oehler goes on to discuss the epidemiology and classification system for relapsing fever (RF), and its broad categorization into tick-borne (endemic) and louse-borne (epidemic) forms. He further describes the characteristics of the soft-shelled Ornithodoros ticks and the Human Body Louse, and differentiates the Hard Tick Relapsing Fevers such as Borellia miyamotoi and B. lonestarii. He then reviews the clinical manifestations, diagnostic criteria, and treatment options for each form of RF. Lastly, Dr, Oehler breaks down treatment and prevention strategies for each form of relapsing fever.

Cerca de 15 milhões de pessoas são esperadas na região parisiense durante a Olimpíada e os Jogos Paralímpicos, que terminam em 8 de setembro. A alta densidade populacional, mesmo temporária, facilita a circulação de várias doenças. É o caso da leptospirose, transmitida pela urina dos ratos. Segundo Pierre Tattevin, presidente da Sociedade Francesa de Infectologia, o risco é alto para quem se aventurar a nadar no rio Sena, já que os roedores estão em toda a parte na capital. Taíssa Stivanin, da RFI em Paris“As autoridades forçaram para poder organizar as competições aquáticas no rio Sena”, alerta o infectologista francês. Não há dados verificados sobre o número de ratos que vivem em Paris, mas, segundo estimativas, há cerca de 1,5 para cada morador.É por essa razão que as contaminações por leptospirose no Sena não estão descartadas, mesmo que a quantidade de coliformes fecais no rio esteja dentro das normas exigidas. “O rato é quem carrega a bactéria da leptospirose. O rio pode até ter ser sido bem higienizado, mas isso não bloqueia a transmissão, que é totalmente possível”, reitera o especialista.A Leptospira, a bactéria que provoca a doença, é encontrada na urina dos ratos e pode contaminar a água, terra e alimentos. Após o contágio, causa sintomas parecidos com os de uma gripe forte: febre alta, dores no corpo e mal-estar. Eles podem demorar entre três dias e três semanas para se manifestar, lembra Pierre Tattevin.“Quem tiver sintomas depois de nadar no rio Sena alguns dias depois deve lembrar de se testar”, diz. "Eles vão depender da quantidade de água ingerida durante o mergulho", explica, citando o rio Sena.Segundo dados da Santé Publique France, a agência sanitária francesa, em 2022 foram diagnosticados cerca de 600 casos de leptospirose no país, mas esse número é provavelmente dez vezes maior, afirma o infectologista francês. "A leptospirose é sensível a praticamente todos os antibióticos. A pessoa pode ter febre, tomar Amoxicilina, ficar boa, e na realidade ter pego a leptospirose sem saber.”Se não for tratada, a doença pode, em alguns casos, provocar uma insuficiência renal grave e levar à morte.De acordo com ele, a tendência é que as contaminações aumentem com o aquecimento global. “É uma bactéria que vive mais em águas quentes. Martinica, Guadalupe e Ilha da Reunião são os territórios franceses onde ela está mais presente. Agora, como a temperatura está subindo na França, vai favorecer a transmissão”, diz.A declaração da doença é obrigatória na França e o teste diagnóstico deve ser feito preferencialmente no hospital, para que o resultado seja obtido instantaneamente. “Não é uma doença grave se for tratada rapidamente. Por isso é importante prestar atenção”, reitera o infectologista.Paris investiu na propaganda em torno da qualidade da água do rio e a própria prefeita de Paris, Anne Hidalgo, deu um mergulho no mês de julho para tranquilizar os mais céticos. Com a chuva, os níveis de poluição no Sena mudam com frequência. Isso faz com que, em alguns dias, ele não seja considerado próprio para banho, como foi o caso nesta segunda (29) e terça-feiras (30).Covid e SífilisEventos como os Jogos Olímpicos, que reúnem milhares de pessoas, também são propícios à propagação do vírus da Covid-19, que continua presente no território francês. "Em termos de risco sanitário, a Covid não é uma grande preocupação. O maior risco é para os atletas, que se ficarem doentes não poderão disputar uma medalha", diz Pierre Tattevin.Segundo ele, isso se explica pela imunidade adquirida pela população ao longo dos anos da pandemia e a evolução do vírus. As infecções agora geram menos casos graves, sem superlotar os hospitais, como foi o caso no início da pandemia, em 2020, e durante algumas ondas da doença.Outro risco apontado pelo infectologista é a propagação de doenças sexualmente transmissíveis, como a sífilis. A Olímpiada, que recebe principalmente um público jovem, que se encontra nas baladas e nos eventos, pode ser um catalisador desse tipo de infecção. Entre 2020 e 2022, houve um aumento de 110% dos casos de sífilis na França, doença que tinha desaparecido em 1990 e recomeçou a circular no país nos anos 2000, segundo um relatório divulgado em 2023 pela Santé Publique France."Uma densidade populacional forte sempre favorece as trocas de micróbios", lembra o presidente da Sociedade Francesa de Infectologia. "Há registros do aumento do número de casos de sífilis em eventos desse tipo."O preservativo, lembra, não é suficiente para proteger contra uma eventual contaminação. "Se há contato com as lesões durante as relações sexuais, mesmo em outras parte do corpo, pode haver o contágio", alerta.E a dengue?Durante a Olimpíada, há ainda patologias como a dengue, o zika , ou o chikungunya, que poderiam se espalhar mais facilmente com a chegada de casos importados. As temperaturas relativamente amenas para o período devem dificultar a reprodução do mosquito Tigre, presente no território francês, segundo o infectologista."Mas o verão continua sendo um período propício para importar doenças tropicais, que podem chegar com viajantes contaminados de regiões como o Brasil, por exemplo", diz.

In this episode, we review the high-yield topic of⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Leptospira interrogans⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

Leptospirosis, a neglected tropical disease caused by spiral-shaped bacteria called Leptospira, is a global health burden.Professor Joseph Vinetz and colleagues at Yale University, USA, and his team's recent findings mark the crucial beginning for long-awaited pan-leptospirosis vaccine development.Read more in Research Features: doi.org/10.26904/RF-148-4837038797Read the original research: doi.org/10.3389/fmolb.2022.1092197

Dr. Zach Johnson joins me to discuss an infertility case that he investigated a few years ago.   Dr. Johnson is the current president of the Saskatchewan Veterinary Medical Association and he is a veterinarian who owns a rural practice in Melville, Saskatchewan.  Zach has led  a number of these types of infertility investigations and we discuss the challenges with sorting out the cause of an infertility problem and the various diagnostics that might be used.00:00 – 2:20   Welcome and Introductions 02:21 – 04:17   Infertility case history04:18 – 5:58 The challenges associated with investigating infertility problems05:59 – 07:40   What diagnostics did we do?07:41 – 09:32   Neospora caninum as a cause of abortion or infertility09:33 – 11:45   IBR and BVD, Leptospira, Trich and Campylobacter11:46 - 18:27 Discussing the diagnosis – Copper deficiency18:28 – 19:43   What was recommended for the herd19:44 - 21:33   The value of pregnancy checking the herd21:34 – 22:35 Wrap up

3.30 Spirochetes Microbiology review for the USMLE Step 1 Exam Spirochetes are spiral or corkscrew-shaped bacteria that stain gram negative. They have a unique endoflagella that distinguishes them from other species of bacteria. The endoflagella rotates within the periplasmic space and causes the bacteria to move, acting as its own propeller. Borrelia burgdorferi, Treponema pallidum, and Leptospira interrogans are the three important species of spirochetes to know. Borrelia burgdorferi causes Lyme disease, which is spread from wildlife to ticks and then to humans. The deer tick, also known as ixodes scapularis, is associated with Borrelia burgdorferi, but deer are not the reservoir for the bacteria. Lyme disease presents in three stages: erythema migrans (bulls-eye rash), flu-like symptoms, Bell's palsy, myocarditis, transient myalgias, arthritis, and neurological symptoms like encephalopathy and peripheral neuropathy. Treponema pallidum causes syphilis, which presents in stages: primary (chancre), secondary (rash), latent, and tertiary (gummas, neurological symptoms). Leptospira interrogans causes leptospirosis (Weil's disease), which is spread from infected animal urine to humans through broken skin, mucous membranes, or ingestion. Leptospirosis presents with flu-like symptoms, jaundice, renal failure, and meningitis.

If you have a dog, you'll want to listen to this one! Leptospira is a genus of spirochete bacteria that can infect many different mammals, from rats to rhinos. Veterinarian Kyra Hartog talks about what Leptospira do in nature and why some animals get Leptospirosis and others do not. She also describes symptoms and treatments and gives advice on how to keep your dogs safe! We also go on a rant about outdoor cats' impact on wildlife that you won't want to miss.Dr. Kyra Hartog, DVM is a veterinarian at a cat and dog clinic in St. Pete, Florida. To follow her work, find her on Instagram: @dr_kyra_h and Twitter: @kyra_hartog.If you want to follow Murray, my cat son (who has been officially diagnosed as extremely cute), his instagram is: @furry_purry_murray.For more info on microbes and to follow updates of this podcast, find @couch_microscopy on Instagram, @CouchMicroscopy on Twitter, or visit www.couchmicroscopy.com/store for merch!Music is "Introducing Cosmic Space" by Elf Power and "Vorticella Dreams" by L. Felipe Benites.While some of the content on this podcast may be relevant to human or veterinary medicine, this information is not medical advice. The views and opinions expressed on this program are those of the host and guests and do not reflect the views of any institution.

Dr. Richard L. Oehler, Professor of Medicine at the Division of Infectious Diseases, Morsani College of Medicine, reviews two important clinical syndromes caused by Spirochetes. Dr Oehler begins by presenting an actual clinical case of Leptospirosis in a returning traveller from the Caribbean. He then discusses the epidemiology of Leptospira, a widespread zoonotic pathogen that favors temperate and topical climates worldwide.He then relates the life cycle, means of transmission, microbiology, clinical manifestations, and most relevant diagnostic studies. He concludes the leptospirosis section by discussing treatment and prevention . The second case he discusses is a febrile illness in a returning traveler from Jordan. Dr. Oehler goes on to discuss the epidemiology and classification system for relapsing fever (RF), and its broad categorization into tick-borne (endemic) and louse-borne (epidemic) forms. He further describes the characteristics of the soft-shelled Ornithodoros ticks and the Human Body Louse. He then relates the clinical manifestations, diagnostic criteria, and treatment options for each form of RF. Lastly, Dr, Oehler breaks down treatment and prevention strategies for each form of relapsing fever.

Pour accéder à l'intégralité de ce podcast et écouter chaque semaine un nouvel épisode du Quart d'Heure Véto, c'est très simple, il vous suffit de vous abonner en cliquant sur ce lien : https://m.audiomeans.fr/s/S-yUNSBZSR Leonie fingerhut et ses collaborateurs ont étudiés l'implication des pièges neutrophiliques extracellulaires (NET), un système initialement censé protéger l'organisme, sur la pathogénie des uvéites, ainsi que l'implication des leptospires dans ce phénomène auto-immun, où l'organisme se retourne contre lui-même. L'objectif de cette étude expérimentale menée principalement ex-vivo à partir de prélèvements biologiques, est d'étudier l'impact des NET chez les patients atteints d'uvéite récurrente équine (URE). Ils ont quantifié plusieurs marqueurs de ces pièges neutrophiliques (ADN libre extracellulaire, nucléosomes, histone H3 citrullinée, complexes histone-myéloperoxydases, interleukine-17, la cathélicidine 1 équine et l'activité DNase I), ainsi qu'un dosage et suivi des auto-anticorps anti-NET dans le sérum et le vitré des chevaux atteints d'URE, en essayant de corréler ces données avec le stade et la sévérité de la maladie (scores ERU et infection ou non par Leptospira). Notes et références Article L.Fingerhut - Ex Vivo and In Vitro Analysis Identify a Detrimental Impact of Neutrophil Extracellular Traps on Eye Structures in Equine Recurrent Uveitis - 2022 Front Immunol. 2022 Feb 10;13:830871. (OPEN ACESS) : https://www.frontiersin.org/articles/10.3389/fimmu.2022.830871/full Retrouvez toute la synthèse sur la Fiche Podcast : https://audmns.com/QVNfNRj Pour nous suivre : 1. Abonnez-vous à notre chaine pour profiter de l'intégralité des épisodes : Le Quart d'Heure Véto : décrypte et résume en moins de 15 min un article de biblio véto - Sur abonnement uniquement, Le Véto du Mois : Partagez le temps d'une interview l'expérience de vétérinaires emblématiques de notre milieu, des rencontres conviviales, comme si nous étions dans votre salon au coin du feu. Podcasts bonus au fil des inspirations... 2. Le Scope Nous partageons avec vous nos dernières découvertes, inspirations, pistes de réflexion, nouveautés… À découvrir et utiliser dès maintenant, TOUT DE SUITE, dans votre quotidien de vétérinaire, de manager, de vie personnelle, de chef d'entreprise… Et tout cela en moins de 5 minutes top chrono un à 2 mardis par mois ! Je souhaite recevoir mon Scope : https://vetmasterclass.com/lescope/ 3. Contactez-nous, suivez-nous et donnez nous votre avis ! Des sujets que vous souhaiteriez approfondir, des références à partager, ou nous faire part de vos feed-backs : Abonnez-vous à notre chaine, donnez nous des étoiles, un commentaire et partagez autour de vous ! Sur notre site : https://vetmasterclass.com/ Sur Facebook : https://www.facebook.com/VmHorse Sur Instagram : https://www.instagram.com/vetmasterclass/ Sur YouTube : https://www.youtube.com/channel/UC18ovcWk9e-mFiTL34OQ03g Sur Linkedin : https://www.linkedin.com/company/vetmasterclass-horse/about/ Belle journée à tous, Et continuez à vivre votre métier avec Passion !

The story of leptospirosis is chock full of variety. In terms of biology, any number of different Leptospira species and serovars can play a role in infection, and the resulting infection can run from asymptomatic to deadly. As for ecology, virtually any mammalian species can either act as an affected reservoir for the pathogens or fall victim to a deadly infection. The history of leptospirosis takes us across continents and through centuries, illustrating how changes in scientific thought and technology shaped our understanding of this and other zoonotic diseases. And the current status of this One Health disease is no less varied, both in the wide distribution of leptospirosis as well as the vastly differing (but disturbingly high) estimates of annual cases and deaths. In this episode, we do our best to tackle as much of the variety in this neglected disease as we can, from its impact on us and our furry friends, to the classic story of its discovery and the biggest remaining gaps in our knowledge today. Tune in for all this and more!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A Leptospirose é uma zoonose de distribuição mundial. Trata-se de uma infecção aguda, causada por uma bactéria do gênero Leptospira, que acomete os humanos e animais e pode ser transmitida pelos roedores sinantrópicos, animais domésticos e silvestres, através de contato direto ou indireto com urina de animais infectados. Esse microorganismo tem como uma de suas características a sobrevivência por tempo indefinido no meio ambiente, além do seu alto grau de variação antigênica que eleva ainda mais a persistência do foco da doença no ambiente.

Nesta edição, o Dr. José Roberto Portante explica as formas de contágio, os sintomas mais frequentes e os métodos de tratamento para os casos leves e graves da leptospirose, doença infecciosa causada pela bactéria Leptospira. Além disso, ele apresenta algumas recomendações para evitar o aumento de número de casos no Brasil.

A Leptospirose é uma zoonose de distribuição mundial. Trata-se de uma infecção aguda, causada por uma bactéria do gênero Leptospira, que acomete os humanos e animais e pode ser transmitida pelos roedores sinantrópicos, animais domésticos e silvestres, através de contato direto ou indireto com urina de animais infectados. Esse microorganismo tem como uma de suas características a sobrevivência por tempo indefinido no meio ambiente, além do seu alto grau de variação antigênica que eleva ainda mais a persistência do foco da doença no ambiente.

Risk for contracting Leptospira bacteria.

La información está en internet desde al menos el 2016, cuando la escasez de alimentos en el país llegó a un punto álgido.

This episode covers leptospira interrogans!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.28.271692v1?rss=1 Authors: Dias Teixeira, R., Holzschuh, F., Schirmer, T. Abstract: Diguanylate cyclases (DGCs) synthesising the bacterial second messenger c-di-GMP are found to be regulated by a variety of sensory input domains that control the activity of their catalytical GGDEF domain. As part of two-component systems, they are activated by cognate histidine kinases that phosphorylate their Rec input domains. DgcR from Leptospira biflexa is a constitutively dimeric prototype of this class of DGCs. Full-length crystal structures revealed that BeF3- pseudo-phosphorylation induces a relative rotation of two rigid halves in the Rec domain. This is coupled to a reorganisation of the dimeric structure with concomitant switching of the coiled-coil linker to an alternative heptad register. Finally, the activated register allows the two substrate-loaded GGDEF domains, which are linked to the end of the coiled-coil via a localised hinge, to move into a catalytically competent dimeric arrangement. Bioinformatic analyses suggest that the binary register switch mechanism is utilised by many DGCs with N-terminal coiled-coil linkers. Copy rights belong to original authors. Visit the link for more info

Today is March 19th, and we're going to cover the last spirochete bacteria, Leptospira spp. and the number one cause of STD's in the US, Chlamydia trachomatis. High-yield, board-relevant information for two organisms and two board-style questions! --- Send in a voice message: https://anchor.fm/bradleysmicroboardreview/message Support this podcast: https://anchor.fm/bradleysmicroboardreview/support

En este Podcast repasamos situación de la leptospira en España, su etiología, epidemiología, evolución de la leptospirosis y abordamos casos clínicos. La seroprevalencia de leptospira en nuestro país es muy variable dependiendo de la región y sus serovares. Actualmente existen nuevas vacunas en el mercado que nos cubren todos las diferentes cepas bacterianas. María López es Licenciada Veterinaria UAB, residente 1er año, Servei Medicina Interna FHCV UAB. Descubre más sobre la Leptospirosis visitando nuestro blog: https://www.affinity-petcare.com/vetsandclinics/es Síguenos en nuestros canales oficiales: Linkedin: https://www.linkedin.com/showcase/vets-and-clinics/?originalSubdomain=il Twitter: https://twitter.com/VetsAndClinics

En este Podcast repasamos situación de la leptospira en España, su etiología, epidemiología, evolución de la leptospirosis y abordamos casos clínicos. La seroprevalencia de leptospira en nuestro país es muy variable dependiendo de la región y sus serovares. Actualmente existen nuevas vacunas en el mercado que nos cubren todos las diferentes cepas bacterianas. María López es Licenciada Veterinaria UAB, residente 1er año, Servei Medicina Interna FHCV UAB. Descubre más sobre la Leptospirosis visitando nuestro blog: https://www.affinity-petcare.com/vetsandclinics/es Síguenos en nuestros canales oficiales: Linkedin: https://www.linkedin.com/showcase/vets-and-clinics/?originalSubdomain=il Twitter: https://twitter.com/VetsAndClinics

En este Podcast repasamos situación de la leptospira en España, su etiología, epidemiología, evolución de la leptospirosis y abordamos casos clínicos. La seroprevalencia de leptospira en nuestro país es muy variable dependiendo de la región y sus serovares. Actualmente existen nuevas vacunas en el mercado que nos cubren todos las diferentes cepas bacterianas. María López es Licenciada Veterinaria UAB, residente 1er año, Servei Medicina Interna FHCV UAB. Descubre más sobre la Leptospirosis visitando nuestro blog: https://www.affinity-petcare.com/vetsandclinics/es Síguenos en nuestros canales oficiales: Linkedin: https://www.linkedin.com/showcase/vets-and-clinics/?originalSubdomain=il Twitter: https://twitter.com/VetsAndClinics

El riesgo de una epidemia de leptospira es real en Puerto Rico debido a la emergencia salubrista por la que atraviesa debido a la acumulación de aguas contaminadas, escombros, inundaciones y daños a la infraestructura sanitaria que provocó el paso del huracán María el pasado 20 de septiembre en Puerto Rico. Por tal razón, la doctora Marielys Otero, infectóloga del Manatí Medical Center (MMC), tomó la batuta el jueves para orientar a toda la población del País en torno al modo de contaminación con el patógeno y las estrategias de prevenirla. - - - Ver entrevista en Youtube: https://www.youtube.com/watch?v=z6SuFpC6AYk - - - Leer artículo completo: https://medicinaysaludpublica.com/prevenga-el-riesgo-de-una-epidemia-de-leptospira-en-puerto-rico/ - - - Visita nuestro sitio web: https://medicinaysaludpublica.com - - - Síguenos en Facebook: https://www.facebook.com/revistamsp/

Leptospirosis is a bacterial zoonotic disease caused by the corkscrew shaped organism, Leptospira. It goes by several other names depending on the locale; mud fever, swamp fever, sugar cane and Fort Bragg fever, among others. It is a disease of both humans and animals. On July 5th, the Philippines Department of Health declared a leptospirosis outbreak in the Metro Manila with a recent increase in cases of the serious bacterial disease. Executive Vice President of the University of the Philippines, Ted Herbosa, MD joined me today for an update on the outbreak situation

Leptospirosis is a bacterial zoonotic disease caused by the corkscrew shaped organism, Leptospira. It goes by several other names depending on the locale; mud fever, swamp fever, sugar cane and Fort Bragg fever, among others. It is a disease of both humans and animals. On July 5th, the Philippines Department of Health declared a leptospirosis outbreak […] The post Philippines: Manila Leptospirosis outbreak update with Dr. Ted Herbosa appeared first on Outbreak News Today.

In this edition of the EVJ podcast, Fernando Malalana discusses their paper, entitled 'The role of Leptospira spp. in horses affected with recurrent uveitis in the UK' (https://onlinelibrary.wiley.com/doi/10.1111/evj.12683) and Sarah Ross discusses their paper 'Prevalence of headshaking within the equine population in the UK' (https://onlinelibrary.wiley.com/doi/10.1111/evj.12708).

Leptospirosis is one of the most significant zoonosis in the world and is more widespread in our canine population than many think. In this podcast, Dr. Maschmedt will discuss Leptospira, the bacterial cause of Leptospirosis, and the various serovars that can be found here in North America. Then we’ll explore the pathogenesis, prevalence, diagnosis and clinical signs of Leptospirosis. Finally, we’ll conclude our talk with a brief history of Leptospirosis vaccines.

Sat, 9 Feb 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/15464/ https://edoc.ub.uni-muenchen.de/15464/1/Rettinger_Anna_Lena.pdf

In Cambodia, the number of reported malaria cases, as well as case fatality rates, continue to decrease since the implementation of large scale malaria programs in the country 10 years ago. However, with the introduction and wide distribution of rapid diagnostic tests (RDTs) for malaria, it also turned out that in many of the clinically suspected malaria cases, no malaria parasites could be detected. As a first step towards developing an algorithm for malaria-RDT negative fever management at peripheral health posts, a cross-sectional, prospective, observational study was designed to investigate the causes of acute malaria-negative febrile illness in rural areas of Cambodia. From January 2008 to December 2010, 1475 study subjects were recruited in three different sites throughout the country. Among the study subjects, 1193 were febrile out-patients and 282 were non-febrile individuals who have been recruited as a control group. A battery of test was run on the samples in the central laboratory in Phnom Penh. In 73.2% of the 1193 febrile outpatient samples, at least one pathogen was identified. In 26.8% of these samples the etiology of the fever remained unknown. Most frequent pathogens detected by molecular diagnostics were P. vivax (26.4%), P. falciparum (20.7%), Leptospira (9.5%), Dengue Virus (5.4%), Influenza Virus A (5.9%), O. tsutsugamushi (3.7%), Influenza Virus B (1.8%), Rickettsia (0.2%) and bacteria from blood culture (Salmonella spp., E. coli, S. pneumoniae, E. cloacae) (0.8%). Conclusions: Malaria is still amongst the principal causes of undifferentiated fever in this setting, even though RDTs did not prove sufficient to diagnose cases of low parasitemia and infections with P. vivax. RDT-negative fever cases should be tested for malaria using microscopy or ideally PCR. If malaria is ruled out, diagnostic tools are needed to distinguish between either viral or bacterial etiology of the fever. Leptospirosis and rickettsial diseases showed to play an important role and are easily treatable with the right antibiotics. However, more research and better diagnstic tools are needed to understand and map the incidence of these diseases in Cambodia.

Canine Leptospirosis in Southern Germany In this study, data of 337 dogs with clinically suspected leptospirosis was evaluated. The dogs were presented to the Clinic for Small Animal Medicine (Medizinische Kleintierklinik) of the Ludwig Maximilians University Munich, Germany, between 1990 and 2004. In all dogs, a microagglutination test used to detect leptospiral antibodies against eight different Leptospira serovars was performed. The aim of the first study was to determine the presence of antibodies against various Leptospira serovars in dogs with clinical leptospirosis in Southern Germany and to compare serovars in regard to history, clinical signs, laboratory findings and survival rate. The purpose of the second study was to identify the Leptospira serovars predominantly inducing antibodies in dogs in Southern Germany and to determine which serovars mainly cause disease. Furthermore, possible predisposition in respect to breed, sex, and age was investigated. 48 % (162) of 337 dogs had antibodies against at least one Leptospira serovar. With the exception of antibodies against the vaccinal serovars copenhageni (70 %) and canicola (38 %), antibodies against grippotyphosa (33 %), bratislava (19 %) saxkoebing (10 %) and sejroe (8 %) were detected most frequently. Of the dogs with antibodies, 26 % (42) had the disease leptospirosis. These dogs most frequently tested positive for antibodies against grippotyphosa (31 %), followed by antibodies against saxkoebing (24 %), copenhageni (17 %), canicola (12 %) and bratislava (7 %). Thus, while antibody titers against vaccinal serovars were found in many dogs, the disease leptospirosis was mainly caused by the serovars grippotyphosa and saxkoebing. Previous studies have suggested that certain serovars are commonly associated with particular clinical symptoms and laboratory findings. However, this was not confirmed in the current study. The ratio of dogs having antibodies against leptospirosis without clinical leptospirosis to dogs with the disease leptospirosis was considerably lower in the serovar saxkoebing (1.6:1) than in other serovars (bratislava 10:1, grippotyphosa 4:1). This may be indicative of a higher pathogenicity of saxkoebing compared to other serovars. Presence of antibodies was diagnosed significantly more often in Bernese Mountain dogs than in other breeds. Also, the disease leptospirosis was significantly more often in this breed. Increasingly, nonvaccinal serovars are the cause of the disease leptospirosis. Leptospirosis vaccines currently available in Europe only contain copenhageni and canicola strains. Since these vaccines are not cross-protective against other serovars, they offer no protection against grippotyphosa and saxkoebing, the serovars most commonly associated with clinically manifest leptospirosis in Germany. A recently developed vaccine, licensed in the USA, contains grippotyphosa and pomona strains, either as a bivalent or as a quadrivalent product in combination with copenhageni and canicola. This study suggests that serovars grippotyphosa and saxkoebing should be added to leptospirosis vaccines available in Germany.

Die Prävalenz von Antikörpern gegen Leptospiren wurde bei 3463 Seren aus 1213 zufällig gewählten bayerischen Milchvieh- und Mutterkuhherden bestimmt. Zirka drei Blutproben je Herde von Rindern im Alter von 6 Monaten bis ca. 2 Jahre wurden mittels MAR (mikroskopische Agglutinationsreaktion) gegen sechs Serovare untersucht. Die Prävalenz von Seren mit Titern von ≥ 1:100 lag für die Serovare hardjo bei 1,04 %, canicola bei 0,09 %, grippotyphosa bei 0,75 %, icterohaemorrhagiae bei 0,26 %, pomona bei 0,00 % und für Serovar bratislava bei 0,14 %. Auf Herdenbasis wurde Serovar hardjo wegen des enzootischen Charakters der Hardjo-Infektion getrennt betrachtet. Basierend auf der Hypothese, dass drei seronegative Proben aus einer Herde eine enzootische Infektion nahezu ausschließen, wurde die Prävalenz von Hardjo-Verdachtsherden mit 1,48 % (18 von 1213 Herden) berechnet. Die 18 Betriebe wurden alle in Südbayern entlang der Alpen gefunden. In dieser Region liegt die Herdenprävalenz bei 5,86 % bei einem Konfidenzintervall von 4,10 %-8,56 % (Binomialverteilung, Vertrauensbereich 95 %). Für die übrigen Serovare war keine regionale Anhäufung zu erkennen. Bei 1,98 % der Herden (Konfidenzintervall 1,45 %-2,76 %) war mindestens eine der drei Proben seropositiv. Zum Zeitpunkt der Blutentnahme wurden die Landwirte zu aktuellen und früheren klinischen Erkrankungen, Leistungsdaten (Milchertrag, Reproduktion) und epidemiologischen Daten befragt. In Herden mit Verdacht auf L.-Hardjo-Infektionen bzw. Infektionen mit anderen Serovaren im Vergleich zu Herden ohne Reagenten war kein signifikanter Unterschied bezüglich aktueller oder zurückliegender Anhäufung von klinischen Erkrankungen mit einem Verdacht auf Leptospirose gefunden worden. Auch war bei den Reproduktionsdaten und bei der Milchleistung kein signifikant negativer Effekt erkennbar. Bei den Herden mit Reagenten gegen Serovar hardjo wurde die Abgabe von Pensionsvieh höchst signifikant öfter praktiziert als bei den übrigen Herden (p < 1,95-14, Fisher´s Exact Test). Dieses Merkmal ist auch abhängig von der Region, da die Sammelweiden im Alpenbereich sehr weit verbreitet sind. Abortfrüchte (N = 154), die von Hoftierärzten zur Diagnostik eingesandt wurden, wurden mittels Leptospira-spezifischer Real-time-PCR untersucht. Als Probe wurde Labmageninhalt verwendet. Bei einem Fetus konnte Leptospira-interrogans-spezifische DNS nachgewiesen werden. Die Anzucht der Leptospiren aus dem Labmageninhalt gelang nicht. Begleitende Seren von Kühen mit Fehlgeburt und Seren von anderen Rindern des Bestandes wurden aus 47 Betrieben zusätzlich zur Abortfrucht eingesandt. Bei 7 (15 %) Betrieben wurden Serovar-hardjo-spezifische Antikörper (MAR 1:200–1:3200) diagnostiziert.