Podcasts about MBC

As Millington Baptist Church begins a new sermon series through 2 Timothy, Pastor Dave Hentschel opens with a message on the urgency and beauty of leaving a legacy of faith. In 2 Timothy 1:1-5, we are brought into the deeply personal relationship between Paul and Timothy and reminded that the gospel does not move forward automatically. It advances when one generation receives it faithfully and passes it on courageously. This sermon reflects on the messengers, the message, and the method God uses to preserve His truth across generations, while calling the church to embrace its role in passing the torch of gospel faithfulness.This message also sets the tone for MBC's 175th anniversary season by connecting the church's present calling with the sacrifices and witness of those who came before. Pastor Dave challenges the congregation to think carefully about the spiritual legacy they have inherited, the responsibility they now carry, and the next generation that must be prepared to receive the faith. With imagery of relay races, three-chair churches, and Paul's final letter from prison, this sermon is both a stirring call to gratitude and a bold exhortation to gospel mission.As we begin this series, may we remember that someone once made room for us to hear the gospel, and may God now use us to make room for someone else.

Philippians begins with an incredible expression of thankfulness from Paul and Timothy. Philippians 1:3–6 “I thank my God every time I remember you. In all my prayers for all of you, I always pray with joy because of your partnership in the gospel from the first day until now, being confident of this: that He who began a good work in you will carry it on to completion until the day of Christ Jesus.” Paul and Timothy are filled with gratitude because of the Philippian believers’ partnership in the gospel. Their support and faithfulness encouraged them and sustained them throughout their ministry and travels. What a reason for joy—to know that you are united with other believers who are praying for you and caring for you out of the blessings God has given them! As a church, how are we doing in partnering together for the mission? Do we pray for one another? Do we care for and support each other? I know we do these things—but I also believe we have even greater opportunities ahead of us to grow in these ways and glorify Christ together. This weekend, we’re excited to explore what it means to partner in the mission of the gospel at MBC as we continue to grow in Christ and move forward for His glory. Join us this Sunday at 8:00 AM or 11:00 AM as we worship together as the body of Christ at Mitchell Berean Church! - Pastor Ben For this week's Scripture and notes: http://bible.com/events/49567368

Send a textWhat do the latest findings from the 2025 San Antonio Breast Cancer Symposium mean for people living with metastatic breast cancer? In this episode, Dr. Bora Lim of MD Anderson Cancer Center joins us to break down the most impactful research and clinical trial updates from SABCS 2025. Together we will explore advances in hormone receptor positive, HER2-positive disease and triple negative disease and discuss how these updates may influence treatment decisions right now. We also wrap up with an audience Q&A, including questions about GLP-1 medications.Listen in for expert insight, practical takeaways, and clarity on the evolving MBC treatment landscape.

Doppelspieltag in der BBL. Benny und Kumbi blicken auf das Spiel gegen Oldenburg und den MBC. Savo Milovic berichtet über unsere Nachverpflichtung Sahmi Willoughby und spoilert den Spoiler-Alarm. Till Pape erzählt, wie es ihm mit der Rückkehr in den Dome als Nationalspieler ergangen ist. Außerdem: Kumbi erklärt den Witz! Viel Spaß beim hören!

1-2부 [뉴스신세계] 1. 李 지지율, 갤럽기준 최고치 2. 친한계, 윤리위원장 사퇴요구 3. 민주당, 전남에서 현장 최고위 - MBC 이정은 기자 - 강성필 더불어민주당 부대변인 - 김종혁 국민의힘 전 최고위원 (출연)

1-2부 [뉴스신세계] 1. 쿠르드, 美 요청에 이란 지상전 가세 2. 사법 3법 국무회의 의결 3. 김건희 특검 ‘준비미흡'에 재판부 질타 - MBC 이정은 기자 - 신인규 변호사 - 장성철 공론센터 소장 (출연) [하프타임] - 방송인 오윤혜 (출연)

1-2부 [뉴스신세계] 1. 코스피-코스닥 폭락 2. 김성태 “이재명에게 돈 안 줬다” 3. 與, 조희대 탄핵 공청회 열었다 - MBC 현영준 기자 - 박진영 전 민주연구원 부원장 - 정옥임 전 의원 (출연)

Seachtain ón Sathran seo chugainn beidh Ceoltóirí Chualann ag dul chun stáitse don uair dheireanach - beidh siad sa Cheoláras Náisiúnta i mBÁC.

1-2부 [뉴스신세계] 1. 美 공습에 하메네이 사망 2. 李 "다주택, 팔기 싫으면 두라" 3. 국힘, '사법개혁 3법' 거부권 요구 장외투쟁 - MBC 현영준 기자 - 장윤선 정치전문기자 - 정광재 동연정치연구소 소장 (출연)

In 2010, Giovanna Podda, shared her terrifying story of repeated alien abductions since she was 4 years old with Mistero, and Italian conspiracy show. She lost her job, was ran out of town and largely disappeared after being discredited by some experts. However, she reappeared in 2025 on MBC's Mysterious TV Surprise in Japan, sharing the same story and incistant it was true.Merchandise: https://freetherabbits.myshopify.comBuy Me A Coffee: DonateFollow: Website | Instagram | X | FacebookWatch: YouTube | RumbleMusic: YouTube | Spotify | Apple MusicFilms: https://merkelfilms.com Email: freetherabbitspodcast@gmail.comDistributed by: merkel.mediaOutro Music:Joel Thomas – Psy-OpYouTube | Spotify | Apple Music

1-2부 [뉴스신세계] 1. ‘사법 개혁‘ 강행에 법원행정처장 사의 2. 서문시장 찾은 한동훈, 정청래도 대구로 3. 전광훈 첫 재판 "내 말 안 들으면 총살" - MBC 이정은 기자 (출연) [이슈하이킥] 李 지지율 최고치…여론조사 추이는? - 김봉신 메타보이스 대표 - 윤희웅 오피니언즈 대표 (출연)

1-2부 [뉴스신세계] 1. 코스피 6300선 돌파 2. 강남 3구 집값 꺾였다 3. 李 지지율 67% 최고치 - MBC 이정은 기자 (출연) [거침없이하이킥] TK 민심도 흔들…국힘 경고등? - 신인규 변호사 - 장성철 공론센터 소장 (출연)

Bean óg ó bhaile na hInse ar stáitse i láthair na huaire i mBÁC leis an dráma Muicín – scéal faoi iasc, sceallóga agus díoltas.

1-2부 [뉴스신세계] 1. 3차 상법 개정안 본회의 상정…국힘 필버 돌입 2. ‘100닉스-20만전자' 현실로 3. 집값 상승 기대 석달만에 꺾였다 - MBC 현영준 기자 (출연) [이슈하이킥] ‘공소취소모임' 출범…계파화 우려는? - 더불어민주당 한민수 의원 (출연)

1-2부 [뉴스신세계] 1. 트럼프, 15% 관세 강행 2. 경기지사 적합도, 김동연 선두 3. 장동혁 "李공소취소 모임, 미친 짓" - 현영준 MBC 기자 (출연) [이슈하이킥1] 지선 D-100, 조국-한동훈 거취는? - 장윤선 정치전문기자 (출연)

1-2부 [뉴스신세계] 1. 장동혁, 사실상 尹어게인 선언 2. 민주 '尹 사면 금지법' 신속 처리 3. 유시민 "李 공소취소 모임, 미쳤나" - MBC 이정은 기자 - 김종혁 국민의힘 전 최고위원 - 강성필 더불어민주당 부대변인 (출연)

1부 [뉴스신세계] 1. 윤석열 내란 1심 ‘무기징역' 2. 尹 무기징역…정치권 반응은 3. 李 "망국적 부동산 공화국 극복해야" - MBC 이정은 기자 (출연) 2부 [이슈대담] ‘내란 우두머리' 윤석열 1심 선고 - 더불어민주당 추미애 의원 - 조국혁신당 박은정 의원 (출연)

1-2부 [뉴스신세계] 1. 대통령 지지율 64%…與 46% vs 野 23% 2. 서울시장 정원오 40% vs 오세훈 36% 3. 정부 증시 정책…상위층 68% '잘한다' - MBC 현영준 기자 (출연) [이슈하이킥] 합당-숙청…설 밥상 의제는? - 장윤선 기자 (출연)

1-2부 [뉴스신세계] 1. 고성국, '가덕도 테러 의혹' 제기 박선원 고소 2. 李 '다주택자 대출 연장' 저격 3. ‘1년 8개월' 김건희, 항소 이유서 제출 - MBC 이정은 기자 (출연) [이슈하이킥] 李 대통령, 다주택자에 또 경고 - 이광수 광수네 복덕방 대표 (출연)

1-2부 [뉴스신세계] 1. 단전·단수 이상민에 징역 7년 - 신인규 변호사 (출연) 2. 장동혁 불참에 대통령 오찬 무산 3. 가덕도 테러범, 고성국 영향 받았나 - MBC 이정은 기자 (출연) [거침없이하이킥] 이상민 1심 징역 7년…적절한가? - 신인규 변호사 - 장성철 공론센터 소장 (출연)

1-2부 [뉴스신세계] 1. 합당 결국 무산…정청래 리더십 ‘타격' 2. 與 강득구, '대통령 합당 찬성' SNS 논란 3. 국힘 서울시당, 고성국에 탈당 권유 - MBC 현영준 기자 (출연) [이슈하이킥1] 대통령, 내일 여야 대표 회동…주요 논의는? - 이규연 청와대 홍보소통수석 (출연)

Scoláirí Phobalscoil Chorca Dhuibhne - d'éirigh thar bar leo i gCraabh Scléip na hÉireann i mBÁC.

1-2부 [뉴스신세계] 1. 특검 추천 논란…“대통령께 죄송” 2. 친한계 김종혁 제명…다음은 배현진? 3. 한성숙 장관, 3채 내놨다 - MBC 현영준 기자 (출연) [이슈하이킥1] 특검 추천 내홍…법사위도 몰랐나? - 더불어민주당 김용민 의원 (출연)

1-2부 [뉴스신세계] 1. 민주·혁신 합당 대외비 문건 파문 2. 장동혁 '직 걸라' 발언에 오세훈도 반발 3. 쿠팡 로저스 경찰 2차 출석 - MBC 이정은 기자 (출연) [이슈하이킥] “내가 바로 오세훈 대항마!“ - 정원오 성동구청장 (출연)

1-2부 [뉴스신세계] 1. 인사 검증에 ‘다주택' 묻는다 2. 중수청 일원화·공소청은 ‘요구권' 가닥 2. 장동혁 재신임·사퇴 전당원 투표로 결정 3. 조국 "당 작다고 자존심도 없나" - MBC 이정은 기자 (출연) [거침없이하이킥] 합당-제명…내홍 확산되는 여야 - 신인규 변호사 - 장성철 공론센터 소장 (출연)

Former government officials arrested, fuel levy reinstated, a cabinet reshuffle, MBC journalists suspended, new music production fees, and much more! Thanks for tuning in! Let us know what you think and what we can improve on by emailing us at info@rorshok.com. You can also contact us on Instagram @rorshok_malawi or Twitter @RorshokMalawiLike what you hear? Subscribe, share, and tell your buds.Former Government Officials Arrested For Financial Crimes: https://www.pijmalawi.org/show-story/pij-exclusive-billions-allegedly-secretly-paid-toReshuffles and Gomo's Town Hall Meetings by Emmanuel Luciano: https://mwnation.com/reshuffles-and-gomos-town-hall-meetings/ Check out our new t-shirts: https://rorshok.store/We want to get to know you! Please fill in this mini-survey: https://forms.gle/NV3h5jN13cRDp2r66Wanna avoid ads and help us financially? Follow the link: https://bit.ly/rorshok-donate

Bainteach le Ceolfhoireann Traidisiúnta Mhuscraí - beidh siad ag seinm sa Cheoláras Náisiúnta i mBÁC an Sathran beag seo.

1-2부 [뉴스신세계] 1. 청와대 다주택자 참모들 집 내놨다 2. 민주당 최고위서 또 합당 충돌 3. 美, 韓 관세 인상 관보 게재 협의중 - MBC 현영준 기자 (출연) [주간정치동형] 합당론 내홍…권력투쟁 번지나 - 이동형 작가 (출연)

1-2부 [뉴스신세계] 1. 대통령 SNS서 부동산 강경 메시지 2. 민주당 최고위서 합당 갈등 표출 3. 오세훈 "장동혁 디스카운트" 언급 - MBC 현영준 기자 (출연) [이슈하이킥1] 민주-혁신 ‘합당 갈등' 재분출…입장은? - 신장식 조국혁신당 의원 (출연)

In this beautifully hopeful episode, Wren, the creator of the Living Our Breast Lives Podcast, is joined by the incredible Metastatic Breast Cancer Thriver, Heather Jose, the MBC thriver living with triple positive metastatic breast cancer for 27 YEARS! Heather Jose is a long-term metastatic breast cancer thriver, advocate, and the host of the podcast I'm Still Here: Lessons from Life with Metastatic Breast Cancer. Diagnosed at 26 and living with metastatic disease for over 25 years, Heather focuses on honest, grounded conversations about what it means to live fully — not just survive — alongside breast cancer. After her diagnosis, Heather went on to adopt a child, redefining what building a family can look like after metastatic breast cancer and showing that life doesn't stop at a diagnosis, it evolves. She has spent decades navigating treatment, motherhood, advocacy, and survivorship, all while helping others feel less alone.Listen to this episode as it breaks down:Who is Heather Jose? – Meeting the woman behind the diagnosisHer MBC story – Diagnosed in 1998, her subtype, and how she's still here decades laterThen vs. now – What MBC treatment looked like then and how far it's comeStrength without the pressure – The moments that carried her through and why the term "inspirational" comes with a heavy weight to itLiving with grief and joy – Mourning the life imagined while fully living the one she hasMotherhood after MBC – Infertility, adoption, and expanding her family against the odds“I'm Still Here” – Why Heather launched her podcast and who it's forLong-term survivorship – What it really means and what she's still dreaming of for the future Living Our Breast Lives Information:Email: livingourbreastlivespodcast1@gmail.comInstagram: @livingourbreastlivesFounder: Wren MorrobelPersonal Instagram: @wren_morrPodcast Guest Speaker: Heather Jose's Information:Email: mail@heatherjose.comInstagram: @heatherbjoseFacebook: Heather JoseWebsite: www.heatherjose.comYouTube: I'm Still Here

1-2부 [뉴스신세계] 1. ‘사법농단' 양승태 2심 징역형 집유 2. 신천지 첫 압수수색‥국힘 당원 가입 의혹 3. 민주-혁신 합당 두고 '밀약설' 등장 - MBC 이정은 기자 (출연) [이슈하이킥] '수도권 6만호'…집값 불안 해소될까 - 한문도 명지대 대학원 실무투자분석학과 교수 (출연)

January 28, 2026 - Learning the Korean language opens the doors into a completely new depth of understanding Korean culture, and perhaps a career you never imagined having. Join acclaimed media figures Tyler Rasch and Nidhi Agrawal—familiar faces from major Korean broadcast networks including JTBC, KBS, and MBC—for a reflection on their personal journeys living in Korea and learning Korean, and how those experiences led to their new venture. In this engaging conversation, Tyler and Nidhi will delve into how language can function as both a cultural bridge and a creative medium, and how Hangeul can travel beyond Korea through design, storytelling, and shared cultural moments in everyday settings. For more information, please visit the link below: https://www.koreasociety.org/arts-culture/2111-from-learning-to-creating

Did you know that as MBC patients get treated with multiple lines of ET, the percentage of patients who develop an ESR1 mutation increases? Credit available for this activity expires: 1/26/27 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/current-and-future-oral-serd-strategies-management-er-2026a100022b?ecd=bdc_podcast_libsyn_mscpedu

1-2부 [뉴스신세계] 1. 한동훈 제명…국민의힘 내홍 격화 2. 尹 관저 골프연습장, ‘초소 공사'로 꾸며 3. 정부, 서울·수도권에 6만호 공급 - MBC 이정은 기자 (출연) [이슈하이킥] 주가는 뛰었는데…실물경제 해법은? - 구윤철 경제부총리·재정경제부 장관 (전화)

1-2부 [뉴스신세계] 1. 김건희 1심 징역 1년 8개월 2. 트럼프 관세 압박, 쿠팡 때문? 3. 李 "담배처럼 ‘설탕세‘ 걷자" - 김정환 변호사 (출연) - MBC 현영준 기자 (출연) [이슈하이킥1] 트럼프 돌발 관세 압박…대처 방안은? - 이규연 청와대 홍보소통수석 (출연)

Featuring perspectives from Dr Angela DeMichele, Dr Komal Jhaveri, Dr Erica Mayer, Dr Hope S Rugo and Dr Seth Wander, including the following topics:  Introduction (0:00) 1985 NCI Consensus Conference on Early Breast Cancer: Sir Richard Peto, FRS (2:01) Current Role of Genomic Assays in Treatment Decision-Making for Localized Hormone Receptor (HR)-Positive Breast Cancer — Dr DeMichele (5:13) Case: A premenopausal woman in her mid 40s with an ER-positive, HER2-negative, node-negative infiltrating ductal carcinoma (IDC) after partial mastectomy/radiation therapy who enrolls in the prospective, observational FLEX study: MammaPrint® low risk — Laurie Matt-Amaral, MD, MPH (15:30) Case: A premenopausal woman in her mid 40s after modified radical mastectomy for T2N0 ER-positive, HER2-negative IDC with an Oncotype DX® Recurrence Score (RS®) of 19 — Swati Vishwanathan, MD Case: A woman in her mid 60s with locally advanced (19 cm) ER-positive, HER2-low (IHC 1+) Stage IIIB mucinous carcinoma breast cancer and an RS of 18 — Alan B Astrow, MD (22:40) Role of CDK4/6 Inhibitors and Other Novel Strategies in Therapy for HR-Positive, HER2-Negative Localized Breast Cancer — Dr Jhaveri (30:18) Case: A woman in her mid 50s with ER-positive, HER2-negative Stage IIB, T2N1 IDC after neoadjuvant dose-dense AC-T, lumpectomy and adjuvant radiation therapy — Eleonora Teplinsky, MD (42:14) Case: A woman in her mid 60s with ER-positive, HER2-negative breast cancer with a surgically removed solitary lung metastasis after 4 years of adjuvant letrozole — Eric Fox, DO (46:32) Evolving Up-Front Treatment Paradigm for HR-Positive, HER2-Negative Metastatic Breast Cancer (mBC) — Dr Rugo (49:45) Case: A woman in her early 80s with Type 2 diabetes, well controlled hypertension and recurrent ER-positive, HER2-negative mBC after 4 years of adjuvant letrozole — Sunil Gandhi, MD (1:02:30) Clinical Utility of Agents Targeting the PI3K/AKT/mTOR Pathway for Patients with Progressive HR-Positive mBC — Dr Mayer (1:06:37) Case: A woman in her late 60s with ER-positive, HER2-low (IHC 1+), PIK3CA-mutant mBC with disease progression after 2 years of adjuvant letrozole — Laila Agrawal, MD (1:20:22) Case: A woman in her early 60s with ER-positive, HER2-low PIK3CA-mutant mBC and disease progression on first-line palbociclib/fulvestrant — Dr Teplinsky (1:26:36) Results from the Global Phase III lidERA Breast Cancer Trial of Giredestrant versus Standard Endocrine Therapy as Adjuvant Treatment for ER-Positive, HER2-Negative Localized Breast Cancer (1:31:48) Current and Future Role of Oral Selective Estrogen Receptor Degraders for Progressive HR-Positive mBC — Dr Wander (1:42:30) Case: A woman in her early 100s with locally advanced ER-positive, HER2-negative breast cancer with disease progression on letrozole, now with an ESR1 mutation — Dr Astrow (1:57:51) CME information and select publications

1-2부 [뉴스신세계] 0. 코스닥 1000 돌파 1. 이해찬 전총리 별세…5일간 사회장 2. 이혜훈 낙마…청와대 인사 검증 논란 3. 민주-혁신 합당 제안 여진 - MBC 현영준 기자 (출연) [이슈하이킥1] 민주-혁신 합당 될까…효과는? - 더불어민주당 김용민 의원 (출연)

1-2부 [뉴스신세계] 1. 국회서 이혜훈 청문회…추가 의혹 도마 2. 민주-혁신 합당 제안 후폭풍 3. 美 투자사들 "韓 정부가 쿠팡 차별" - MBC 이정은 기자 (출연) [이슈하이킥] ‘합당 제안' 후폭풍…왜 지금? - 박수현 더불어민주당 수석대변인 (출연)

In this podcast, experts William J. Gradishar, MD, FASCO, FACP; Stephanie L. Graff, MD, FACP, FASCO; and Cynthia X. Ma, MD, PhD; discuss current and emerging therapeutic options, including next-generation endocrine therapies, to target the estrogen receptor signaling pathway for the treatment of hormone receptor–positive/HER2-negative (HR+/HER2–) metastatic breast cancer (MBC).

1-2부 [뉴스신세계] 0. 코스피 5000 새 역사 썼다 1. 정청래, 민주당-조국당 합당 제안 2. 이상민·박성재도 ‘중형' 철퇴 맞나? 3. 김병기 배우자 경찰 피의자 출석 - MBC 이정은 기자 (출연) [거침없이하이킥] 정청래, 혁신당에 합당 제안…정치권 파장은? - 신인규 변호사 - 장성철 공론센터 소장 (출연)

1-2부 [뉴스신세계] [미니인터뷰] 1. “12.3은 내란”…한덕수, 징역 23년 - 김정환 변호사 (전화) 2. 이재명 대통령 신년 기자회견 3. 홍준표 "尹, 신천지 몰표로 후보 됐다" - MBC 현영준 기자 (출연) [주간정치동형] 검찰·이혜훈·집값…역대 최장 대통령 기자회견 - 이동형 작가 (출연)

High-quality behavioral healthcare scales only when outcomes, engagement, and coordination are designed into the system from day one. In this episode, Colleen Marshall, Chief Clinical Officer at Two Chairs, discusses how integrating therapy and psychiatry under one roof improves outcomes, reduces drop-off, and removes friction for patients. She explains measurement-based care (MBC), why real-time feedback in sessions drives better results, and how clinician training unlocks adoption. Colleen explores patient engagement, including why rapid access and strong matching matter and how coordinated care prevents conflicting treatment plans. She also breaks down value-based care in behavioral health, sharing how outcomes and retention can anchor shared-risk partnerships with payers. Finally, Colleen looks ahead to the future of behavioral health, including the responsible use of AI to support clinicians while maintaining ethical and effective care. Tune in and learn how outcomes, engagement, and coordination can redefine success in behavioral healthcare! Resources: Connect with and follow Colleen Marshall on LinkedIn. Follow Two Chairs on LinkedIn and visit their website.

1-2부 [뉴스신세계] 1. 김병기, 재심 포기 이어 탈당계 제출 2. '이혜훈 청문회' 후보 없이 공방만 3. 한동훈 “송구”…장동혁은 침묵 - MBC 현영준 기자 (출연) [이슈하이킥1] “검찰개혁 정부안, 전면 수정해야” - 신장식 조국혁신당 의원 (출연)

1-2부 [뉴스신세계] 1. 법원, 尹 체포 방해 혐의 등 '징역 5년' 선고 2. 李대통령-여야 지도부, 국힘 불참 속 오찬 3. 김경·강선우·前보좌관, 모두 진술 엇갈려 - MBC 이정은 기자 (출연) [이슈하이킥1] 법원 "尹, 경호처 사실상 사병화" - 더불어민주당 윤건영 의원 (출연)

1-2부 [뉴스신세계] 1. 내일 尹 ‘체포방해' 선고…2시 생중계 2. 장동혁, 한동훈 제명 결정 연기 3. 경찰, 김경 재소환…“심려 끼쳐 죄송” - MBC 이정은 기자 (출연) [거침없이하이킥] 한동훈 제명 ‘보류'…張 속내는? - 신인규 변호사 - 장성철 공론센터 소장 (출연)

Featuring perspectives from Prof Giuseppe Curigliano, Prof Nadia Harbeck, Dr Ian E Krop, Dr Nancy U Lin and Dr Joyce O'Shaughnessy, including the following topics:  Introduction (0:00) Considerations in the Care of Patients with Localized HER2-Positive Breast Cancer — Prof Harbeck (1:39) Case: A woman in her mid 50s presents with locally advanced ER-positive, HER2-positive breast cancer — Alan B Astrow, MD (12:52) Case: A woman in her mid 40s with ER-positive, HER2-positive Stage II breast cancer s/p neoadjuvant TCHP with residual disease receives adjuvant T-DM1 but discontinues due to neuropathy — Laila Agrawal, MD (20:02) Previously Untreated HER2-Positive Metastatic Breast Cancer (mBC) — Prof Curigliano (25:10) Case: A woman in her early 80s presents with de novo metastatic (bone-only) ER-positive, HER2-positive breast cancer — Zanetta S Lamar, MD (35:03) Optimal Management of Brain Metastases in Patients with HER2-Positive Breast Cancer — Dr Lin (46:20) Case: A woman in her early 60s with ER-positive, HER2-positive breast cancer develops a cerebellar metastasis while receiving adjuvant anastrozole after prior anti-HER2 therapy — Justin Favaro, MD, PhD (59:41) Case: A woman in her early 40s with ER-negative, HER2-positive mBC develops a headache shortly after neoadjuvant TCHP, surgery and postneoadjuvant T-DM1 and is found to have an isolated 4-cm brain metastasis — Dr Agrawal (1:05:36) Selection and Sequencing of Therapy for Relapsed/Refractory HER2-Positive mBC in the Absence of CNS Involvement — Dr Krop (1:12:00) Case: A woman in her early 40s with ER-positive, HER2-positive mBC receives THP (docetaxel/trastuzumab/pertuzumab) and maintenance tucatinib with trastuzumab/pertuzumab on a clinical trial and now has disease progression — Yanjun Ma, MD, PhD (1:23:04) Tolerability Considerations with HER2-Targeted Therapies — Dr O'Shaughnessy (1:29:32) Case: A woman in her mid 60s presents with localized ER-negative, HER2-positive infiltrating ductal carcinoma — Erik Rupard, MD (1:46:06) Case: A woman in her early 70s with recurrent ER-positive, HER2-positive mBC receives trastuzumab deruxtecan (T-DXd) and has concerning pulmonary symptoms but without findings on diagnostic imaging — Kimberly Ku, MD Case: A woman in her mid 40s with ER-positive, HER2-positive breast cancer metastatic to the brain and lung who received multiple prior treatments responds to T-DXd but develops Grade 1 interstitial lung disease — Richard Zelkowitz, MD (1:49:49) CME information and select publications

1-2부 [뉴스신세계] 1. 윤석열 사형 구형 2. 국힘 윤리위, 한동훈 기습 제명 3. 김경 “1억 줄때, 강선우 함께 있었다” - MBC 현영준 기자 (출연) [이슈하이킥1] 말 많은 검찰개혁…청와대 입장은? - 이규연 청와대 홍보소통수석 (출연)

1-2부 [뉴스신세계] 1. 김경 귀국, 새벽까지 경찰 조사 2. 김병기 전 원내대표 윤리심판원 출석 3. 새 원내대표에 한병도 의원 선출 - 현영준 MBC 기자 (출연) [이슈하이킥1] 공소청·중수청 운영안 공개…개혁 맞나? - 김용민 더불어민주당 의원 (출연)

Featuring perspectives from Dr Javier Cortés, Dr Rita Nanda, Prof Peter Schmid and Dr Priyanka Sharma, including the following topics:  Introduction (0:00) Case: A woman in her early 80s with multiple comorbidities and triple-negative breast cancer (TNBC) develops bone-only metastases 4 months after declining capecitabine for post-neoadjuvant residual disease — Justin Favaro, MD, PhD (1:50) Case: A woman in her mid 70s with ER-negative, HER2-low (IHC 1+), PIK3CA-mutated, PD-L1-positive metastatic breast cancer (mBC) after receiving 3 cycles of neoadjuvant paclitaxel/carboplatin/pembrolizumab, which was discontinued — Alan Astrow, MD (6:47) Previously Untreated Metastatic TNBC (mTNBC) — Prof Schmid (10:47)  Case: A woman in her early 80s with multiregimen-recurrent ER-positive, HER2-low (IHC 1+) ESR1-mutant mBC receives sacituzumab govitecan — Jennifer Yannucci, MD (27:19) Case: The role of datopotamab deruxtecan (Dato-DXd) for patients with ER-positive, HER2-low mBC who experienced disease progression on prior trastuzumab deruxtecan (T-DXd) — Ranju Gupta, MD; Case: A woman in her late 70s with bilateral recurrence in the lungs of ER-negative, HER2-low (IHC 1+) breast cancer (PD-L1 TPS 20%) receives Dato-DXd with durvalumab on protocol — Yanjun Ma, MD, PhD (31:35) Integrating Antibody-Drug Conjugates (ADCs) into the Management of Endocrine-Resistant Hormone Receptor-Positive mBC — Dr Sharma (36:31) Case: A woman in her early 70s with recurrent ER-negative, HER2-low (IHC 2+) mBC receives sacituzumab govitecan and achieves complete remission — Dr Gupta; Case: Management of neutropenia associated with sacituzumab govitecan — Gigi Chen, MD (50:30) Case: A woman in her late 60s with recurrent ER-negative, HER2-low (IHC 1+) mBC (HER2 V69L mutation) receives T-DXd and achieves a complete response but develops Grade 1 interstitial lung disease — Dr Gupta; Case: Management of T-DXd-related side effects — Laila Agrawal, MD (54:10) Selection and Sequencing of Therapy for Relapsed/Refractory mTNBC — Dr Nanda (58:59) Case: A woman in her early 40s with multiregimen-recurrent ER-positive, HER2-low mBC who has experienced severe nausea with past treatments is about to initiate T-DXd — Atif M Hussein, MD, MMM (1:12:40) Tolerability and Other Practical Considerations with ADCs and Other Cytotoxic Agents for mBC — Dr Cortés (1:18:10) CME information and select publications

Featuring perspectives from Dr Lisa A Carey and Dr Rita Nanda, including the following topics:  Overview: Molecular basis of antibody-drug conjugate (ADC) toxicities — Sequencing of ADCs and mechanisms of resistance (0:00) Case: A woman in her late 60s with localized triple-negative breast cancer develops myocarditis during neoadjuvant therapy with chemotherapy/pembrolizumab — Richard Zelkowitz, MD (8:22) Case: A woman in her mid 70s with recurrent ER-negative, HER2-low, PD-L1-positive metastatic breast cancer (mBC) who experiences disease progression on nab paclitaxel/atezolizumab responds to sacituzumab govitecan — Ranju Gupta, MD (26:43) Case: A woman in her early 80s with recurrent ER-positive, HER2-low (IHC 1+) mBC experiences disease progression on trastuzumab deruxtecan (T-DXd), then receives datopotamab deruxtecan and develops pulmonary symptoms — Laila Agrawal, MD (32:11) Data Review: T-DXd (37:51) Case: A woman in her early 70s with recurrent ER-positive, HER2-low (IHC 1+) mBC, including bladder metastases, experiences disease progression after palbociclib/letrozole, then capivasertib/fulvestrant, then nab paclitaxel — Justin Favaro, MD, PhD (44:02) Case: A woman in her late 70s with ER-positive, HER2-low mBC who experiences disease progression after 1 year of ribociclib/letrozole receives sacituzumab govitecan — Erik Rupard, MD (55:19) CME information and select publications