Podcasts about stage iv

In today's episode, Saranne shares three uncomplicated but potent cancer-busting reminders that listeners can incorporate into their daily routines. These reminders encourage individuals to pause for a moment to laugh, stretch, or breathe. By embedding these micro habits into their daily regimen and making them a regular practice, listeners have the opportunity to elevate their mood, diminish stress, and enhance their overall health and well-being.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

The concept of 'entertaining your cancer' might sound odd at first, but it truly showcases the strength of our thoughts and feelings concerning our health. Saranne made the choice to confront her cancer with positivity and a good dose of humor, which helped reduce stress and presented a unique coping mechanism for her illness. Although this approach might not resonate with everyone, it serves as a reminder that there isn't just one correct method to overcome cancer. Everyone's journey is different and unique.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne discusses the strategies to alleviate the misery and discomfort often accompanying a cancer diagnosis. Drawing from her experience in conquering Stage IV cancer, Saranne offers practical tips for tackling the challenges one step at a time, aiming to improve the overall quality of life for those going through the cancer journey. Stay tuned as Saranne shares insightful ways to navigate uncomfortable encounters and provides a humorous take on finding moments of joy amidst difficulties. Join us as we explore the small yet significant factors that can make a big difference in the fight against cancer.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne delves into the concept of life's speed bumps, particularly in relation to a cancer diagnosis. She shares her journey of discovering ways to decelerate and cherish life beyond the bounds of cancer treatments. Urging listeners to discover ways to integrate these 'speed bumps' into their daily lives, Saranne also invites listeners to share their unique strategies for adopting a slower pace, aiming to enhance the overall richness of life.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

 Thank You!! Beating Cancer Daily is a 2025 People's Choice Podcast Awards Finalist Today on Beating Cancer Daily, Saranne brings awareness to the often-overlooked intersection between migraines and cancer by inviting Jacqui Bryan, an expert in nutrition and functional medicine, for a practical, compassionate discussion. While neither has experienced a migraine firsthand, both women share their care for loved ones who suffer from these debilitating headaches. Together, they unpack the distinct triggers—especially food-related ones, such as additives like MSG and compounds in wine and cheese—that can set off migraines, explore how hormonal shifts, lifestyle factors, and stress amplify symptoms, and provide actionable strategies for both migraine prevention and in-the-moment relief. Saranne's signature blend of warmth and humor lightens the conversation, while Jacqui offers clear nutritional advice and underscores the importance of keeping a symptom journal. This episode is a rich resource for anyone living with migraines or supporting someone with chronic pain in the context of cancer, including those facing the unique challenges of Stage IV diagnosis.Jacqui Bryan is a certified nutrition specialist, whole health educator, health coach, and registered nurse with a specialization in functional medicine. Her expertise covers the intersection of nutrition, lifestyle, and chronic illness, providing compassionate and science-backed guidance for those seeking to improve their well-being. Jacqui's holistic approach and longstanding commitment to patient education make her a valued presence for anyone navigating migraines, cancer treatment, or both."When I laugh like a belly laugh, I can only focus on that one feeling at that given time. And it's a gift to be able to disengage from whatever stress is going on in my life for a laughing moment." ~Jacqui Bryan Today on Beating Cancer Daily:·     Migraines can be triggered by specific foods and additives, including MSG, red wine, aged cheeses, and tannins found in certain fruits and teas·     Women are two to three times more likely than men to experience migraines, pointing to hormonal influences·     Keeping a detailed food and symptom journal is a powerful tool for identifying individual migraine triggers·     Dehydration, blood sugar imbalances, sleep deprivation, and stress can all precipitate migraines or make them worse·     Magnesium-rich foods (like pumpkin seeds), as well as riboflavin (B2) and CoQ10, may help reduce migraine frequency for some people·     Strong odors, flashing lights, and excessive noise can exacerbate migraines, so creating a calm, dark environment is helpful during an attack·     Humor, laughter, and mindfulness techniques play important roles in managing stress, which may help prevent or lessen the impact of migraines·     Open communication with healthcare providers is vital when considering food-based or supplemental strategies for migraine management, especially for those with a cancer diagnosisGuest Contact Information: Jacqui BryanRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_SuggestionsTo sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne takes a chilly approach to wellness as she discusses the potential benefits of cold therapy and its effects on cancer treatment. With her signature optimism and wisdom gained from beating Stage IV cancer, Saranne invites listeners to consider the idea of integrating cold showers into their daily routine. Join her as she delves into the research, shares her personal experiences, and offers insights into how this unconventional practice can contribute to overall well-being. Get ready to explore new perspectives and find moments of joy as we continue to beat cancer daily together.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne teams up with the fabulous comedian Missy Hall, weaving humor into the tapestry of survival and self-care. As someone who's triumphed over Stage IV cancer, Saranne is no stranger to the emotional rollercoaster that follows recovery. Join us for a hilarious yet heartwarming exploration of the art of saying no and setting boundaries after treatment. From the unexpected hilarity of completing customer service surveys to discussing the creative process behind turning real-life struggles into side-splitting comedy, this episode is a candid blend of laughter and life lessons. Get ready to chuckle, reflect, and reclaim your joy as Saranne and Missy bring a comedy twist to the cancer conversation.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

n today's episode of Beating Cancer Daily, Saranne explores the ubiquitous nature of humor even during the most challenging times of a cancer journey. Having surpassed a Stage IV cancer diagnosis, Saranne emphasizes how embracing a comic perspective can offer a unique tool for coping and thriving. Listen in as she delves into the inspirational words of Dr. Seuss, "From there to here, from here to there, funny things are everywhere," encouraging listeners to cultivate their own "humor notebook." Through this exercise, you'll learn to spot the absurdities and quirks around you, turning potential pain points into moments of laughter. Join Saranne in this enlightening session and learn how to harness humor as we continue to beat cancer daily together.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne delves into the intriguing topic of receiving signs from loved ones who have passed away. Drawing from her poignant experiences, including those with a patient named Rivka and her father and grandfather, Saranne explores the notion that those we've lost might still communicate with us in mysterious ways. From flickering lights to uncanny coincidences, she shares personal stories and research that suggest these signs are more common than one might think. Join Saranne as she navigates this fascinating subject, offering comfort and wonder to anyone coping with grief or seeking a deeper connection. Get ready to laugh, learn, and live your best days as we embark on this journey of beating cancer daily together.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne explores how managing cancer can be compared to handling a challenging job. Having conquered Stage IV cancer through three surgeries, 44 radiation treatments, and over two years of chemotherapy, Saranne shares insightful ways to improve the cancer journey using principles from Patrick's book on workplace dissatisfaction. Discover how addressing anonymity and irrelevance can transform your treatment experience. Join Saranne as she delves into meaningful, practical steps to not only survive but thrive during this journey, and continue living your best days as we beat cancer daily together.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's Beating Cancer Daily episode, Saranne explores creating a living legacy with excitement and optimism. As someone who has beaten Stage IV cancer for 30 years, Saranne shares her perspective on why it's essential to consciously think about and enjoy crafting a legacy, regardless of the timeline we have. Join her as she discusses fun and creative ways to leave a lasting imprint, from recording books for loved ones to planting living markers of our time. Get ready to be inspired and discover how embracing the concept of legacy can bring joy and depth to our lives as we beat cancer daily together.2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

 Today on Beating Cancer Daily, Saranne brings her signature warmth and wisdom to an engaging exploration of the pancreas, focusing on its essential and often overlooked impact on health, particularly during and after cancer treatment. As a Stage IV cancer survivor, Saranne reflects on her journey to better health by nurturing each organ individually, placing special emphasis on the pancreas as a foundation for surviving intense therapies. Saranne is joined by the much-loved Jacqui Bryan, who shares expert advice on nutrition and practical steps for optimizing pancreas health. Their discussion reveals surprising facts about the pancreas, its multiple functions, what can threaten its wellness, and the proactive lifestyle adjustments anyone can make to support this crucial organ. Jacqui Bryan is a certified nutrition specialist, functional medicine expert, whole health educator, registered nurse, and a 22-year cancer survivor. Her broad expertise and empathetic style have inspired listeners to embrace healthier habits and empowered countless individuals to understand and care for their bodies through evidence-based nutrition and holistic strategies. “Our job is to make it easier for our body, not more challenging.” ~Jacqui Bryan Today on Beating Cancer Daily:·     The pancreas is involved in both digestion and blood sugar regulation, making it essential to overall health for everyone.·     Inflammation or damage to the pancreas can cause serious conditions like pancreatitis, diabetes, and malnutrition.·     Choosing nutrient-dense foods and reducing sugar, processed foods, and alcohol can lower the burden on the pancreas.·     Consuming antioxidants, fiber, omega-3 fatty acids, magnesium, and B vitamins supports pancreatic strength and resilience.·     Lifestyle changes such as adequate hydration, regular physical activity, and stress management help protect the pancreas.·     Regular checkups and blood sugar monitoring, including the A1C test, are important for tracking pancreatic and whole-body health.·     Certain medications, viral infections, genetics, and abdominal trauma can raise the risk of pancreatic issues.·     Small changes, such as habit stacking, mindful fiber intake, and eating a colorful variety of plant foods, can make a significant impact on pancreatic and overall wellness. Guest Contact InformationJacqui Bryan Website 2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

In today's episode of Beating Cancer Daily, Saranne unveils a powerful yet simple strategy to manage medical communication more effectively. Drawing from her experience of beating Stage IV cancer, she emphasizes the importance of creating a dedicated email account solely for medical correspondence. Saranne explains how this practice helps organize medical records, maintain boundaries between one's health and personal life, and reduce stress. Join her as she provides step-by-step guidance on setting up this system and shares its benefits to her cancer treatment journey. Let's laugh, learn, and live our best days beating cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne is joined by the courageous and hilarious Missy Hall, a breast cancer survivor and comedian who brings her trademark humor and authenticity to the conversation. Together, they delve into Missy's recent journey post-treatment, which took an unexpected turn when her daughter's pregnancy presented a concerning medical scare. Through emotional highs and lows, they explore the profound impact of sharing laughter and finding lightness in the face of adversity. Join them as they navigate the complexities and joys of survivorship, offering invaluable insights and a touch of comedy.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's Beating Cancer Daily episode, Saranne explores nature's profound impact on the well-being of cancer patients and survivors. Having triumphed over Stage IV cancer, Saranne emphasizes the importance of connecting with the natural world, even amidst the demanding schedules and stress of treatment. Listen in as she shares compelling studies, practical tips for experiencing nature, and personal anecdotes on how the simple act of being outdoors or listening to nature sounds can be restorative. Join Saranne in this enlightening discussion and find new ways to incorporate the healing power of nature into your daily routine. Get ready to laugh, learn, and live your best days as we continue beating cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne introduces a unique and powerful method to navigate cancer treatments easily. Drawing from her own experience of beating Stage IV cancer, Saranne explores the concept of using carefully curated music playlists to transition into and out of treatments. Inspired by an encounter at a Broadway show, she shares insights on creating personalized soundtracks to uplift the spirit, reduce stress, and reclaim a sense of normalcy. Join Saranne as she delves into this creative strategy and offers examples to help you craft your own therapeutic playlists. Get ready to immerse yourself in a blend of music, motivation, and heartfelt advice as we live our best days, beating cancer together daily.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, the troubling issue of cancer-related leg cramps and their potential causes. With 30 years of triumph over Stage IV cancer, Saranne offers personal insights and medical insights gleaned from her experiences and consultations. She explores the reasons behind these painful cramps, such as electrolyte imbalances and dehydration, and provides actionable tips like stretching and proper vitamin intake. Saranne even shares a lighthearted moment about the origins of the term "Charley horse." Join us as we tackle this unwelcome side effect, striving to beat cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne hosts an uplifting pep rally designed to boost spirits and foster connection. Having triumphed over Stage IV cancer for 30 years, Saranne delves into the science and art of cheering someone up, sharing practical tips from BetterUp.com and Teen Vogue. From sending motivational tunes to building forts and smashing plates (safely), Saranne explores various ways to spread joy and support loved ones. Join her as she discusses the importance of listening, appreciating each other's strengths, and creating fun, stress-relieving moments. Together, let's laugh, learn, and live our best days in the pursuit of beating cancer daily.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

 Confusion between creatine and creatinine sets a humorous yet informative tone as Saranne welcomes Jacqui Bryan back for her 90th appearance on Beating Cancer Daily. This episode is dedicated to understanding creatine, a supplement well-known among bodybuilders but now gaining attention among everyday exercisers, cancer survivors, and even people with neurodegenerative diseases. Jacqui clarifies the true uses and potential risks of creatine, especially for those in cancer treatment or with pre-existing kidney issues like Saranne, and breaks down food sources, supplemental dosing, and scientific research on its benefits and possible drawbacks.Jacqui Bryan is a certified nutrition specialist, whole health educator, health coach, and registered nurse. With her expertise in functional medicine, she educates and supports those seeking to optimize wellness during and after cancer treatment, emphasizing food-first approaches and personalized safe supplementation. "Creatine has anti-inflammatory, antioxidant components to it, which make it appealing to anybody, but especially people that are in cancer treatment." ~Jacqui Bryan Today on Beating Cancer Daily:·     Creatine is naturally produced in the body and found in foods like beef, pork, fish, poultry, eggs, and bone broth.·     It is widely known for improving exercise performance and muscle growth, offering energy for short bursts of intense activity.·     Creatine has potential anti-inflammatory and antioxidant properties, with some research suggesting it may reduce cancer incidence.·     There is emerging evidence that creatine could provide support for neurodegenerative disorders by offering cognitive and neuroprotective benefits.·     Creatine supplementation may cause side effects such as fluid retention, digestive issues, and should be avoided by individuals with kidney disorders without medical consultation.·     Sourcing creatine from whole foods is preferred over supplements due to better overall absorption and fewer side effects.·     Dosage recommendations involve a loading phase followed by a maintenance phase, but always under medical supervision, especially for those undergoing cancer treatment or at risk for kidney issues.·     Supplements can be expensive and are only as good as your ability to absorb them, so consider your digestive health and consult with a healthcare professional before starting anything new. Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode of Beating Cancer Daily, Saranne brings the power of emotional security and confidence for those navigating a cancer journey to the forefront. Having triumphed over Stage IV cancer herself, Saranne reflects on the importance of maintaining self-esteem and a positive mindset through challenges. She explores nine empowering phrases recommended by Harvard-trained psychologist Dr. Courtney Warren, designed to help individuals build emotional resilience. Listen in as Saranne shares her experiences and insights, helping us laugh, learn, and live our best days while beating cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne is joined by the courageous and hilarious Missy Hall, a breast cancer survivor and comedian who brings her trademark humor and authenticity to the conversation. Together, they delve into Missy's recent journey post-treatment, which took an unexpected turn when her daughter's pregnancy presented a concerning medical scare. Through emotional highs and lows, they explore the profound impact of sharing laughter and finding lightness in the face of adversity. Join them as they navigate the complexities and joys of survivorship, offering invaluable insights and a touch of comedy.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne delves into the world of tumor humor as she reflects on her experience with hair loss during her cancer journey. As a survivor, Saranne understands the emotional impact of losing hair during cancer treatment and shares how she approached this challenging experience with a comic perspective. Join her as she discusses the humorous side of coping with hair loss and invites listeners to participate in creating their tumor humor. Prepare for a lighthearted and insightful discussion on finding laughter in the face of adversity as we beat cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne delves into gratitude for cancer treatment and survival. As a Stage IV cancer survivor for 30 years, Saranne discusses her own experience with gratitude and the impact it has had on her journey. She highlights the significance of practicing gratitude in the face of adversity. Join Saranne as she explores the science behind gratitude and its effects on the mind, body, and spirit, and offers practical strategies for cultivating a grateful mindset. Tune in for a powerful conversation that may transform your approach daily. Laugh, learn, and find inspiration as we navigate the path of Beating Cancer Daily.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode of Beating Cancer Daily, Saranne talks about fearlessness amidst the journey of battling cancer. Having beaten Stage IV cancer herself, Saranne reflects on her experiences and explores the scientific aspects of bravery and anxiety. She examines a recent study on serotonin's role in fear management and shares personal anecdotes, including a harrowing ocean rescue with her daughter, to illustrate her innate calmness and courage. Tune in to discover practical techniques like the four R's—Relabel, Reattribute, Refocus, Revalue—and learn how humor and perspective can help manage fear and anxiety. Get ready to laugh, learn, and live your best days as we navigate this journey of beating cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne celebrates a special occasion - her milestone 30th year of being cancer-free. Join Saranne as she delves into the fascinating history and traditions of birthdays, sharing interesting facts she recently discovered. As she reflects on her experiences with birthdays post-diagnosis, including her love for cakes and the meaningful ritual her father shared with her, Saranne also delivers some lighthearted birthday jokes and extends heartfelt blessings to those listening. So, whether it's your birthday today or not, get ready to laugh, learn, and share this significant moment's joy with Saranne on Beating Cancer Daily.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor  Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In this episode, our guest, Dr. Andrew Armstrong of Duke University, discusses recent advances that men should know to overcome prostate cancer. We ask about former President Joe Biden's diagnosis. What does it mean to have Stage IV prostate cancer and a Gleason score of 9? News outlets have reported that Mr. Biden's previous prostate […]

 On this episode of Beating Cancer Daily, Saranne welcomes back Jacqui Bryan for an eye-opening discussion on the myths and truths of metabolism, especially as it relates to cancer recovery and survivorship. Drawing on their personal experiences with cancer as well as their professional expertise, Saranne and Jacqui unravel common misconceptions about metabolism, from late-night eating and fasting trends to miracle supplements, and explore practical strategies to support metabolic health during and after cancer treatment.Jacqui Bryan is celebrated for her integrative approach to wellness, combining advanced training in nutrition and functional medicine with deep compassion for those navigating health challenges. As a cancer survivor herself, Jacqui brings both scientific insight and real-life wisdom to her work, guiding clients toward balance and well-being through nutrition, personalized lifestyle changes, and evidence-based health education."I like to think of us all as snowflakes. No two snowflakes are alike. And so no two metabolisms are alike." ~Jacqui Bryan Today on Beating Cancer Daily:·     Every person has a unique metabolism influenced by genetics, age, sex, muscle mass, and lifestyle factors·     Metabolism changes naturally over a lifetime and can be impacted significantly by cancer treatments and the stress of illness.·     Eating late at night doesn't slow down metabolism, but it may disrupt sleep and the body's natural detoxification processes.·     Intermittent fasting and very low-calorie diets may slow metabolism and cause muscle loss, highlighting the need for balanced nutrition during cancer recovery.·     Muscle mass is a key driver of metabolism, making strength training and regular physical activity especially important during survivorship and as we age.·     Supplements and trendy "metabolism boosters" offer minimal, if any, real benefit, and could be harmful without proper medical guidance.·     Managing stress, getting adequate sleep, and nurturing social connections all contribute to optimal metabolic and overall health.·     Consistent eating routines, whole nutrient-dense foods, and joyful living support well-being during cancer treatment and beyond.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_SuggestionsTo sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

In today's episode of Beating Cancer Daily, Saranne delves into the transformative power of reclaiming your personal space during a cancer journey. Drawing from her own experience of overcoming Stage IV cancer, Saranne emphasizes the importance of making your bedroom a sanctuary of rest, relaxation, and hope. She shares practical tips on decluttering, organizing, and introducing soothing scents into your space, ensuring it remains a haven free from constant reminders of illness. Tune in as Saranne guides you through creating a healing environment that supports your mind, body, and spirit. Get ready to laugh, learn, and live your best days as we continue beating cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne and breast cancer survivor Missy Hall bring a lighthearted perspective to living as cancer survivors. They discuss Missy's recent comedy show, sharing the humorous challenges of balancing a late-night performance with the early morning recording. As they delve into laughter-inducing strategies for dealing with insomnia and anxiety, Saranne and Missy share their unique self-cheering and singing habits, highlighting how humor and joy play a vital role in their survivorship. Join them as they explore the power of laughter and find moments of happiness amid their cancer journey.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

In this powerful episode, host Lisa Malia sits down with Leslie Ferris Yerger, CEO and founder of My Density Matters, for an intimate and eye-opening conversation about breast density, advocacy, and early detection of breast cancer. If you've ever wondered why breast density is such a critical, yet often overlooked, part of the breast cancer conversation, this episode is a must-listen. Lisa and Leslie share their personal stories as breast cancer survivors and passionate advocates, revealing how their own experiences with missed diagnoses due to dense breast tissue ignited their mission to empower women with crucial information.   Leslie recounts her shocking diagnosis of stage four metastatic breast cancer just two months after an “all clear” mammogram and ultrasound—a story that highlights the urgent need for better awareness and screening options. Together, they discuss what women should know about lobular cancer, the limitations of traditional screenings, why advocacy is so important, and what steps everyone can take to protect themselves and their loved ones.   They also touch on barriers to care, tips on understanding your risk and screening reports, and the grassroots power of women supporting one another. Tune in for a moving and educational conversation that might just change how you think about breast health—and give you exactly the tools you need to advocate for yourself and others.   Timestamps: 00:00 Empowering Women on Breast Density 06:04 Unexpected X-Ray Discoveries 09:51 "Invisible Lobular Breast Cancer" 12:10 Breast Density Diagnosis Challenges 13:42 Forming Alliances for Breast Density Awareness  16:59 Bridging Gaps in Cancer Care 20:06 Dense Breasts: Ultrasound Limitations 23:06 Metastatic Cancer and Osteoporosis Medications 28:54 Family Support and Open Conversations 30:24 "Breast Cancer Risk Assessment Guide" Learn more about The Clear Pathways Program, Walk, Summit, App and Initiative powered by For The Love Of Cups and join our task force or advisory board: https://www.breastdensitysummit.org/ Leslie Ferris Yerger is a Tedx speaker, author of Probably Benign, and a women's advocate with a laser focused mission. Leslie was diagnosed with Stage IV breast cancer in November 2017 after an ‘all clear' mammogram and ultrasound, experiencing firsthand the failings of our current breast cancer screening standards. As Founder and CEO of the not-for-profit My Density Matters, Leslie is determined to empower women to find out their breast density, learn their options, and advocate for themselves to get the additional breast cancer screening they need, so that her story doesn't become their story. Leslie lives in Hawthorn Woods, IL with her husband John. She has 3 grown children: Evan, Julia, and Megan. My Density Matters: https://www.mydensitymatters.org LinkedIn: ttps://www.linkedin.com/company/my-density-matters Instagram: https://www.instagram.com/mydensitymatters/   #breastcancer #breastdensity #mammogram #nonprofitleadership

In this special extended episode of Beating Cancer Daily, Saranne welcomes listener Leah to share her powerful and inspiring experience using visualization techniques during her cancer journey. Saranne, herself a Stage IV cancer survivor for 30 years and founder of the ComedyCures Foundation, introduces Leah's remarkable story of incorporating guided imagery alongside conventional treatment. Leah recounts how focused visualization and positive thinking played a critical role in her recovery and mental well-being. To complement Leah's story, Saranne closes the episode with her own detailed guided “golden honey” visualization, described as a daily mental practice supporting her healing through treatment and beyond. Leah, a cancer survivor and mother, turned to positive thinking and guided imagery to cope with her diagnosis and rigorous treatment while raising young children. Encouraged by her instructor, she developed a vivid daily visualization routine designed to dissolve tumors and expel cancer from her body, documenting notable personal results and a significant sense of empowerment. Her story offers a unique and hopeful perspective on integrative healing approaches for cancer patients. "I was able to literally see, like, a tumor shrinking and shrinking and shrinking. And after my six chemo's, I no longer even felt a lump." ~Leah Today on Beating Cancer Daily:·     A listener shares how guided visualization supported her breast cancer recovery alongside chemotherapy.·     Leah describes using vivid imagery of light dissolving tumors daily, which gave her hope and control during treatment.·     Having clear goals and consistently focusing on positive outcomes can foster a sense of empowerment.·     Visualization is described as a tool to supplement—not replace—medical treatment, always requiring thorough consultation with a healthcare team.·     Saranne offers her own golden honey and light visualization, a relaxation and healing practice she has used for decades.·     Mind-body practices like imagery and meditation are not substitutes for treatment, but may complement medical care by supporting mental well-being.·     The episode stresses the importance of never delaying or changing treatment decisions without in-depth discussions with one's medical team.·     Listeners are reminded of the transformative potential of imagination and mindset in healing, while prioritizing safety and professional guidance.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

Saranne returns to Beating Cancer Daily to continue her empowering discussion on focusing energy where it matters most: the things within our control. After living for over 30 years with Stage IV cancer, Saranne shares personal insights and practical strategies inspired by a powerful Etsy poster and guidance from the University of Rochester Medical Center. In this episode, she explores how building small, meaningful habits, micro habits, around attitude, boundaries, and self-care can offer a sense of stability and comfort, even in the midst of the most uncertain medical journeys. Listeners are encouraged to craft their own lists of what they can take charge of and discover relief in letting go of what they can't. "Hopefully, as we start to build these muscles together, you will also start feeling that things are more within your control. And the things that aren't within your control, we can start to let go of."  ~Saranne Today on Beating Cancer Daily:·     Focusing on what is truly within your control can create a meaningful sense of stability during cancer treatment·     Developing micro habits, small, repetitive positive actions, offers real and lasting change·     Attitude, personal boundaries, and how you respond to challenges are controllable elements·     Directing your time and energy toward what you value most can foster resilience and hope·     Medical circumstances may be uncontrollable, but your reaction and mindset can be chosen each day·     Healthy routines around eating, exercise, relaxation, and self-care play a major role in well-being·     Letting go of things you cannot change helps reduce stress and emotional overwhelm·     Community support and shared strategies are invaluable tools on the cancer journey Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

Today on Beating Cancer Daily, Saranne, the founder of the ComedyCures Foundation and a Stage IV cancer survivor for over 30 years, brings a much-needed lighthearted perspective to the realities of life with cancer. Through her signature humor and wisdom, she shares a laugh-out-loud colonoscopy joke and introduces listeners to the 31-Day Tumor Humor Challenge, designed to help reframe stressful cancer experiences. Saranne also discusses an inspiring Etsy poster that lists things we simply cannot control, encouraging listeners to identify and release these burdens, thereby finding greater healing and joy. With personal anecdotes about the controversial yet deeply meaningful decisions she made throughout her cancer journey, Saranne reminds everyone that humor and self-reflection go a long way in cultivating resilience on the toughest days. “My colonoscopy just confirmed that I'm beautiful inside and out.” ~SaranneToday on Beating Cancer Daily:·     Humor can be a powerful tool for coping with cancer procedures and stress·     The 31-Day Tumor Humor Challenge encourages finding laughter in daily cancer experiences·     Some things in life, such as others' opinions or the weather, are outside of our control and not worth our energy·     Letting go of what you can't control allows for more space to heal and enjoy meaningful moments·     It's important to critically evaluate advice and only keep what truly aligns with your own values·     Making bold or unconventional care decisions can be empowering and provide important life lessons to loved ones·     Having comic perspective helps foster resilience and lighten overwhelming situations·     Sharing your lists and humor can inspire others and build a supportive, positive community Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg.   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, Saranne delves into the powerful impact of questioning authority and thinking independently, a lesson ingrained in her by her father. Having triumphed over Stage IV cancer, Saranne recounts how her father's persistent advice not to be a "sheep" helped her defy daunting medical prognoses. Tune in as she reveals how this mindset not only played a crucial role in her cancer journey but also empowered her to overcome personal challenges like navigating a complex divorce. Be inspired to laugh, reflect, and drive forward as we continue our shared journey of Beating Cancer Daily, together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

 Today on Beating Cancer Daily, Saranne brings her playful energy to a fascinating discussion with certified nutrition specialist Jacqui Bryan about one of the world's lesser-known superfoods: the lupini bean. Inspired by a childhood bean song and Jacqui's curiosity, the episode unfolds as both a humorous exploration and a science-backed investigation into why this Mediterranean staple might be an unsung hero for cancer thrivers and anyone pursuing a healthier, protein-rich diet. From ancient Egyptian fields to modern kitchen tables, the conversation highlights the powerhouse nutrition of lupini beans, their unique preparation requirements, and the surprising pitfalls for those seeking plant-based alternatives, especially for individuals facing Stage IV cancer, diabetes, or food allergies. Throughout, Saranne and Jacqui keep things candid, myth-busting, and practical, inviting the global community to rethink beans, share recipes, and laugh along the way. Jacqui Bryan is a certified nutrition specialist, whole health educator, health coach, functional medicine expert, and registered nurse. With over 90 episodes on Beating Cancer Daily and a deep commitment to empowering people through nutrition, Jacqui brings clarity and actionable advice for navigating food choices during and after cancer. Her multi-layered expertise shines as she demystifies complex topics in everyday language, helping listeners rethink their pantry staples. "They have twice the amount of protein in them as chickpeas so they're a really good option for people that are looking to get more protein in their diet." ~Jacqui Bryan Today on Beating Cancer Daily:·     Discover how lupini beans went from the fields of ancient Egypt to the hearts (and guts) of health seekers worldwide.·     Discover why lupini beans pack a double protein punch compared to chickpeas, with fewer carbs, making them a game-changer for plant-based eaters and those managing diabetes.·     Hear Jacqui explain how these beans nurture gut bacteria, making them gut-friendly warriors in your fight for better health, including during Stage IV cancer journeys.·     Get a clear warning: raw lupini beans contain toxic alkaloids and should never be eaten without proper preparation—safety first!·     Find out why people with peanut allergies need to think twice before reaching for these yellow gems.·     Unpack the sodium surprise—most store-bought lupini beans are swimming in salt, but a good rinse can help keep blood pressure in check.·     Test drive lupini beans in salads, roasted veggie bowls, or whizzed into a creamy, protein-packed lupini hummus (your veggies will thank you).·     Join the global Beating Cancer Daily community by sharing your own lupini bean recipes or questions, turning this episode into a worldwide taste test. Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

In this uplifting and celebratory episode, Saranne reflects on an incredible milestone for Beating Cancer Daily—being named among the top cancer support resources in the world, just seven months after launching. Drawing from her journey as a Stage IV cancer survivor and founder of the Comedy Cures Foundation, Saranne describes how the vision for this daily cancer support initiative was brought to life, inspired by both scientific principles and community needs. She shares the emotional journey of seeing Beating Cancer Daily recognized alongside global cancer institutions, highlighting the power of positivity, humor, and community in navigating the cancer experience.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

BUFFALO, NY – July 24, 2025 – A new #casereport was #published in Volume 16 of Oncotarget on July 23, 2025, titled “Extracorporeal blood filtration leading to tumor growth arrest and reduced analgesic requirements in Stage IV poorly differentiated pancreatic adenocarcinoma: A case report.” In this report, Susanna Ulahannan from the University of Oklahoma Health Sciences Center and colleagues describe the use of extracorporeal blood filtration in a patient with metastatic pancreatic cancer. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up. Metastatic pancreatic cancer is difficult to treat and is often diagnosed at an advanced stage. In this case, a 51-year-old woman with stage IV poorly differentiated adenocarcinoma chose not to undergo standard chemotherapy. Instead, she received extracorporeal blood filtration with the Seraph® 100 device, which is designed to remove circulating tumor cells (CTCs) from the bloodstream. CTCs are thought to contribute to the spread of cancer to other organs. “Circulating tumor cells (CTC's) are tumor cells that are shed from the primary tumor and travel via blood or lymphatic system to form micro metastases in distant organs under a suitable environment.“ The patient received between nine and twelve treatments over the course of a year. These treatments were performed both abroad, where the device is approved for this use, and under a clinical protocol in the United States. Medical imaging showed that her disease remained stable, with no new metastases detected. She also reported improvements in appetite, energy levels, and pain control. Her opioid use was reduced by 90%. Blood samples confirmed a drop in CTC levels after treatment. This observation supports the idea that removing CTCs might help limit cancer progression in some patients. However, given that this is a single case report, larger clinical studies are needed to evaluate the effectiveness of this approach. The mechanism behind the patient's pain relief is not fully understood. Authors suggest that it may be related to the reduction of tumor cells or inflammatory molecules in the blood. Researchers noted that pro-inflammatory cytokines, known to influence pain, could also have been affected by the filtration process. This is the first documented case of stable disease and reduced symptoms following CTC filtration in advanced pancreatic cancer. While these findings should not be generalized, they highlight an approach outside standard protocols that should be further explored in clinical research. Future studies will be needed to determine whether this method can contribute to symptom management or disease control in other patients with metastatic pancreatic cancer. DOI - https://doi.org/10.18632/oncotarget.28756 Correspondence to - Susanna Ulahannan - susanna-ulahannan@ouhsc.edu Video short - https://www.youtube.com/watch?v=dro6iUGDrVQ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28756 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, extracorporeal blood filtration, circulating tumor cells, metastatic pancreatic cancer, seraph 100, OncoBind To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Gillian Lichota was diagnosed at 35 and 40—first with Stage III and later with Stage IV breast cancer. She is a mother, mountain climber, adventure travel enthusiast, and the Founder and CEO of the iRise Above Foundation, a nonprofit organization dedicated to empowering and supporting young women through breast cancer. In this episode, Gillian reads her essay “An Open Letter to My Daughter, Layke” from the 2024 “Mothers & Daughters” issue of Wildfire Journal. Her piece is about the ways motherhood transforms us. April and Gillian will discuss the healing found in witnessing your child's life, leading your children with intention, the legacy offerings we want for our children,and modeling vulnerability. They will also discuss Gillian's careers from marine biologist to founder of a non-profit breast cancer organization. More about Gillian:https://www.iriseabovefoundation.org/https://www.instagram.com/irise_abovehttps://www.instagram.com/irise_abovehttps://www.facebook.com/iRiseAboveFoundationhttps://www.youtube.com/channel/UCf8r9NWe1TzJ77m2_zeeLtAPurchase the “Mothers & Daughters” issue of Wildfire Journal: https://www.wildfirecommunity.org/shop/p/mothers24Buy the Wildfire book Igniting the Fire Within: Stories of Healing, Hope & Humor, Inside Today's Young Breast Cancer Community: https://www.amazon.com/dp/B0BJVJ629F?ref_=pe_3052080_397514860Get the free Wildfire “Hot Flashes” email newsletter: https://www.wildfirecommunity.org/newsletter?rq=newsletterLearn about Wildfire writing workshops: https://www.wildfirecommunity.org/workshopsShop Wildfire merch & more: https://www.wildfirecommunity.org/shop*Free* Get Wildfire and The Burn freebies here: https://www.wildfirecommunity.org/freeMore about Wildfire Journal: https://www.wildfirecommunity.orghttps://www.instagram.com/wildfire_bc_magazine/https://www.facebook.com/wildfirecommunityInformation on submitting your story for consideration to be published in Wildfire Journal: https://www.wildfirecommunity.org/submissions

In today's Beating Cancer Daily episode, Saranne is again joined by breast cancer survivor and comedian Missy Hall. They discuss the vulnerability and excitement of starting a new chapter in survivorship after receiving a clean scan. Saranne and Missy share their personal experiences and how they have learned to exhale and reclaim their lives post-treatment. They delve into the role of comedy in their journey and how it has helped them navigate the complexities of survivorship. Join them as they explore the power of laughter, the importance of self-compassion, and the journey to finding joy after facing Stage IV cancer. Get ready to be inspired, uplifted, and empowered as you listen to their enlightening conversation.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, Saranne explores the transformative power of vision boards for those navigating life with or beyond cancer. Having beaten Stage IV cancer herself, Saranne knows firsthand the impact that visualizing a positive future can have on one's journey. She explains how creating a vision board—whether physical or digital—can help manifest desires in various areas of life, including health, relationships, finances, and dreams. Join her as she provides practical tips for crafting your own vision board, shares resources, and even sprinkles in some humor to make the process enjoyable. Let's laugh, learn, and envision our best days as we continue this adventure of beating cancer daily together.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, Saranne delves into body weight fluctuation during cancer treatment. As a survivor of Stage IV cancer, Saranne openly discusses her own experiences, from weight loss due to treatment side effects to unexpected weight gain from medications. She emphasizes the importance of understanding these changes and seeking professional guidance to maintain a healthy balance. Listen in as she shares insightful tips and personal anecdotes, and discover how humor has played a crucial role in her cancer journey. Get ready to gain valuable insights and grab a dose of laughter as we navigate the impact of weight during cancer treatment with Saranne.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, Saranne shares how humor has been her lifeline through life's toughest challenges, including Stage IV cancer and divorce. Drawing laughter from her own experiences and the wit of celebrated comedians, Saranne reveals how comedy became a tool for stress relief and resilience during some of the most difficult periods of her life. She explores the therapeutic power of joke books, the connection between major life stress and cancer, and the unique comfort found in seeing the funny side, even when tackling subjects as heavy as cancer and separation. Along the way, Saranne encourages listeners to use humor to process pain, manage anxiety, and connect with others facing similar journeys.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, Saranne explores a perspective rarely discussed in the cancer community: the desire some individuals have to keep their cancer journey completely private. After three decades of openly living with Stage IV cancer, Saranne shares a powerful encounter with a woman at a recent support event who prefers not to talk about her cancer at all—not with friends, family, or even herself. Saranne reflects on this “drive by” approach to cancer, comparing it to simply getting through treatment quickly and moving on without discussion. In this episode, Saranne challenges the prevailing focus on open dialogue and support groups, and asks listeners to consider the validity and importance of every person's unique way of processing cancer.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

 Today on Beating Cancer Daily, Saranne welcomes Jacqui Bryan, a renowned expert in nutrition, functional medicine, and wellness, for a practical and uplifting conversation about strength training, no matter where you are on your cancer journey. Inspired by Jacqui's impressive arm tone, Saranne shares her newfound commitment to building muscle and the positive changes she has already noticed. Together, they discuss the vital role of resistance training in maintaining physical and emotional resilience, especially for those in or recovering from cancer treatment, including those with mobility restrictions or living with Stage IV cancer. The conversation offers relatable anecdotes, actionable strategies, and encouragement for survivors, patients, and caregivers at any stage. Jacqui Bryan is a certified nutrition specialist, functional medicine expert, whole health educator, Certified Health Coach, and registered nurse, as well as a 22-year survivor herself. Drawing from her extensive background and personal cancer journey, Jacqui has appeared in nearly 90 episodes of Beating Cancer Daily, empowering listeners with her expertise and relatable insights into healthy living, personalized exercise, and overcoming obstacles with compassion and humor. "Strength training can help us be more resilient, not only physically, but emotionally. And I think that's a big part." ~Jacqui Bryan Today on Beating Cancer Daily:·     Everyone, regardless of age, diagnosis, or mobility, can benefit from integrating some form of strength training into their routine·     Strength and resistance training can be adapted for individuals who are bedridden or have limited mobility, using tools such as hand weights, resistance bands, or even household items.·     Functional fitness prepares your body for everyday activities and helps prevent injuries from tasks like shoveling snow or carrying groceries.·     Men and women, especially those in or past menopause, can protect against bone loss and muscle loss with regular resistance exercise.·     Strength training offers emotional empowerment, improves mood, reduces anxiety, and supports a feeling of accomplishment, even with light weights.·     Weight-bearing exercise is associated with a reduced risk of cardiovascular disease and improved insulin sensitivity, which supports overall metabolic health.·     It's essential to consult with healthcare providers before starting any new exercise, especially for those undergoing active treatment or with conditions such as lymphedema.·     Starting small, habit stacking, and seeking support from physical therapists or community resources can make building muscle a safe, sustainable, and enjoyable process. Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

Dr. Lyudmila Bazhenova is back on the podcast to discuss the latest update of the living guideline on therapy for stage IV NSCLC without driver alterations. She shares the studies the Expert Panel reviewed in the first- and second-line settings, including NIPPON, HARMONi-2, and DUBLIN-3. Although these studies do not impact the existing guideline recommendations, Dr. Bazhenova provides context and comments on ongoing trials that will influence the next iteration of the living guideline. Read the full living guideline update “Therapy for Stage IV Non-Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2025.1” at www.asco.org/thoracic-cancer-guidelines TRANSCRIPT This guideline, clinical tools, and resources are available at www.asco.org/thoracic-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO-25-01062 Brittany Harvey: Hello, and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today I'm interviewing Dr. Lyudmila Bazhenova from University of California San Diego Moores Cancer Center, co-chair on "Therapy for Stage IV Non–Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2025.1." It's great to have you back on the show today, Dr Bazhenova. Dr. Lyudmila Bazhenova: It's my pleasure to be here. Brittany Harvey: And then before we discuss this guideline update, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Bazhenova, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into the content here, Dr. Bazhenova, this living clinical practice guideline for systemic therapy for patients with stage IV non–small cell lung cancer without driver alterations is updated on an ongoing continuous basis. So what prompted this latest update to the recommendations? Dr. Lyudmila Bazhenova: Living ASCO guidelines are designed to keep pace with rapidly evolving evidence that impacts treatment of our patients with lung cancer. As a committee, we are tasked with regular review of the published literature and determine if the new data warrants changes to existing recommendations. So in this recently published update, we evaluated new trials related to treatment of patients with metastatic lung cancer without driver alterations. Brittany Harvey: Excellent. Thank you for that explanation of the process. So, you just mentioned that the panel reviewed new trials for this update. So, which particular updated evidence did the panel review on first-line treatment options for patients with good performance status across histology and PD-L1 expression status, and how did this impact the recommendations? Dr. Lyudmila Bazhenova: For the first-line treatment option for patients without driver alterations, two studies met our criteria for review. One was the NIPPON trial from Japan, the second was the HARMONi trial. None of those two trials resulted in change in our guidelines, but I think they are giving us some additional information that would be useful for the way we treat patients with non–small cell lung cancer without driver alterations. For example, if we take those patients, we currently have several treatment options as a first line. One is monotherapy immunotherapy. You can give pembrolizumab as an example, and that was based on the KEYNOTE-024 and KEYNOTE-042 trials. Then we have a platinum doublet plus immunotherapy, and there are several trials that did that pathway. And then we have also an option of giving our patients dual IO immunotherapy combination, such as CheckMate 9LA and POSEIDON. At this point, we do not have any randomized trials comparing those three treatment modalities head-to-head. And the NIPPON trial was interesting to us because it was the first trial to compare CheckMate 9LA regimen, which is again, dual immunotherapy plus chemo, versus KEYNOTE-189 or KEYNOTE-407, which is a chemotherapy plus immunotherapy. And as a result of the study, while chemotherapy plus ipilimumab-nivolumab led to numerically higher overall survival, the difference was not statistically significant. And what is concerning in that trial is that we saw a higher number of treatment-related death occurring in nivolumab and ipilimumab arm compared to the pembrolizumab-chemotherapy arm. As a matter of fact, the trial was terminated early because of the increased risk of death. If you look at the treatment-related death in CheckMate 9LA, the 9LA study reported the treatment-related death to be 2%, and then in the NIPPON trial, the treatment-related death was 7%. Why is that happening? It's really difficult to say. The study was done in Japan. Maybe there is some pharmacogenomic differences between global population and Japan population. But certainly the higher rate of adverse events needs to be taken into account. Another interesting thing about this trial is that it did not show any differences in a subset analysis for patients with squamous histology as well as PD-L1 negative tumor. So while this does not change our current guidelines and CheckMate 9LA treatment still remains an appropriate treatment option, it kind of raises the possibility that this combination could be associated with a higher toxicity. And we do have a randomized US-based trial that is ongoing, and we are hoping that eventually we will be able to answer that question after the trial will be completed. The second trial we reviewed is HARMONi-2. So HARMONi-2 was a randomized, double-blind study which is conducted primarily in China, looking at bispecific PD-L1 and VEGF antibody called ivonescimab. And that took patients who were PD-L1 positive, as defined as more than 1% expression, and patients were randomized to pembrolizumab versus bispecific ivonescimab. And the study was positive. It showed improvement in median progression-free survival of 11 months versus almost 6 months in bispecific versus pembrolizumab. There were, however, higher grade 3 events in the ivonescimab arm. At this point, we are not changing our recommendations because this trial was done in an ex-US population, and we are awaiting a similar trial ongoing in the United States before we change recommendations and decide if ivonescimab needs to be included in our guidelines. Brittany Harvey: This context is very helpful when clinicians think through the data behind these options. And it's important that the panel reviews this evidence, even if it doesn't prompt a change to the recommendations. And we'll await results of those trials that you mentioned to further inform this guideline. So then beyond those studies for first line, what updated evidence did the panel review for second-line and subsequent treatment options for patients with good performance status, and how did this impact the recommendations? Dr. Lyudmila Bazhenova: So for second line, only one trial met the criteria, and that was DUBLIN-3. DUBLIN-3 is a phase 3 single-blind randomized trial comparing docetaxel versus docetaxel plus plinabulin. And the study enrolled patients with second or third line. They have to have had platinum-based chemotherapy and progressed. Plinabulin is an interesting compound. It's a small molecule tubulin binder that prevents polymerization of tubulin and appears to impact dendritic cell maturation and T-cell activation. This study enrolled 559 patients, randomly assigned them to two groups. And one important information about this study is that was a study that was envisioned before immunotherapy became a standard mainstream treatment for first-line therapy. And only 20% of patients had prior PD-1 exposure. So therefore, the results of that study need to be taken into context of this population no longer existing in the United States because we use PD-L1 inhibitors in the first line. And we saw that interesting in the plinabulin arm had lower rates of neutropenia but higher rates of serious adverse events. And at this point, we are not changing our guidelines for mainly two reasons. Number one, low number of patients that received prior treatment with first-line immune checkpoint inhibitors, as well as a modest overall survival benefit of this trial. Brittany Harvey: Understood. I appreciate you describing that study as well and why that evidence didn't prompt a change to those particular recommendations. So then, what should clinicians know as they implement this living guideline, and how does this new evidence impact clinicians and patients? Dr. Lyudmila Bazhenova: At this point, none of the studies that we reviewed resulted in a change in guidelines. We are still waiting for more global results from some of the studies that I highlighted. It shows that there's still a lot of questions we need to be answering in those patients. And I'm hoping that with future clinical trials, we will be able to definitively maybe recommend one treatment over another. But at this point, all the treatments that I mentioned before remain appropriate for patients with stage IV non–small cell lung cancer without driver alterations. Brittany Harvey: Definitely. And then you just mentioned that there's still a lot of outstanding questions in this field. You've mentioned a couple different studies where we're awaiting evidence. Beyond those that you already mentioned, what is the panel examining for future updates to this living guideline? Dr. Lyudmila Bazhenova: Right now, our next task is to come up with a full guidelines update. ASCO have certain rules for the guidelines committee members. And so we are gearing for a full guideline update, which hopefully will be ready by the end of 2025. Brittany Harvey: Excellent. We'll look forward to that full update of the living guideline, and we'll still await results of these ongoing trials to further inform this living guideline. So I want to thank you so much for your work to rapidly and continuously update this living guideline, and thank you for the time today, Dr. Bazhenova. Dr. Lyudmila Bazhenova: My pleasure. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/thoracic-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you've enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Dr. Joshua Reuss joints that podcast to discuss the latest changes to the living guideline on stage IV NSCLC with driver alterations. He discusses the new evidence for NSCLC with EGFR mutations and NRG1 fusions and how this impacts the latest recommendations from the panel. He shares ongoing research that the panel will review in the future for further updates to this living guideline, and puts the updated recommendations into context for clinicians treating patients with stage IV NSCLC. Read the full living guideline update “Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2025.1” at www.asco.org/thoracic-cancer-guidelines TRANSCRIPT This guideline, clinical tools, and resources are available at www.asco.org/thoracic-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology, https://ascopubs.org/doi/10.1200/JCO-25-01061 Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today I'm interviewing Dr. Joshua Reuss from Georgetown University, co-chair on "Therapy for Stage IV Non–Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2025.1." It's great to have you here today, Dr. Reuss. Dr. Joshua Reuss: Thank you. Happy to be here. Brittany Harvey: And then before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Reuss, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So to dive into what we're here today to talk about, Dr. Reuss, this living clinical practice guideline for systemic therapy for patients with stage IV non–small cell lung cancer with driver alterations is updated on an ongoing basis. So what prompted this latest update to the recommendations? Dr. Joshua Reuss: Yes, thank you. It's very important that we have living guidelines that are continuously updated. We obviously don't live in a static environment where things are non-changing, and we really need to apply the most up-to-date and current evidence to treat our patients with the most effective strategies, the most groundbreaking strategies. And so to have guidelines that can be disseminated, particularly these ASCO guidelines, to treating providers is incredibly important. So, with any of these updates, we review ongoing studies, published work, for the quality of evidence to see if it's something that warrants making adjustments to our guidelines or at least incorporating the information so that providers can review it and incorporate this into their own personal decision-making. So in this particular update, we reviewed evidence particularly pertaining to EGFR-mutated non–small cell lung cancer and non–small cell lung cancer harboring an NRG1 fusion. Brittany Harvey: Yes, certainly there's a lot of new evidence in the advanced non–small cell lung cancer field, and so we appreciate the panel's continuous review of this evidence. So then you just mentioned two separate areas where the panel reviewed new evidence. So starting with that first one, what updated evidence did the panel review on first-line treatment options for patients with EGFR alterations, and how did this impact the recommendations? Dr. Joshua Reuss: Yes, so advanced EGFR-mutated non–small cell lung cancer, at least with classical activating alterations - that is our exon 19 deletions and our exon 21 L858R mutations - is something that's really evolved rapidly in the last few years. You know, for many years, we basically, for the frontline treatment setting, were saying, "Okay, we have a targeted therapy, osimertinib. We're going to give that, and we're going to see what effect we can get out of that," with, you know, a median time of duration of treatment response averaging around 18 months, knowing that there are some that that's a lot longer and some that are a lot shorter. But recently, we've seen a lot of data emerging on combination strategies. The guideline has already been updated to incorporate two of these combinations: osimertinib with chemotherapy based off of the FLAURA2 trial, and then the combination of amivantamab with lazertinib based off of the MARIPOSA trial. And that was data on progression-free survival that was published and led to those particular recommendations. Now, more recently, we've seen data come out in smaller, randomized studies for other combinations. And more recently, we reviewed the RAMOSE study. So this was a phase II, open-label, randomized trial for patients with tyrosine kinase inhibitor–naive and really, treatment-naive advanced EGFR-mutated non–small cell lung cancer harboring one of these two classical EGFR alterations, randomized to either osimertinib alone or osimertinib with the combination of ramucirumab, which is an anti-VEGF agent. There's been a lot of data, preclinical and clinical, for the role of VEGF blockade, particularly in EGFR-mutated non–small cell lung cancer, so exploring the combination of this for synergy in the frontline setting really made a lot of sense. So again, this was a phase II trial that randomized patients prospectively to one of these two regimens. The population here is really what we typically see with EGFR-mutated non–small cell lung cancer, predominantly a younger population - median age on this study was 65 - predominantly female - 71% female - and predominantly nonsmokers. Now, what this study showed was that at a median follow-up of 16.6 months, the progression-free survival favored the combination arm with a median progression-free survival of 24.8 months with the combination of osimertinib plus ramucirumab versus 15.6 months for osimertinib alone, for a hazard ratio of benefit of 0.55. The landmark one- and two-year endpoints for progression-free survival also favored the combination arm, and response rates were relatively comparable between groups, with overall adverse events being more frequent in the combination group, specifically high blood pressure, proteinuria, and epistaxis, which are our common adverse events related to VEGF-blocking agents. So, it's good to see data in this space. Now, of note, though, this was a phase II study, so not a phase III level of evidence. In addition, when looking at the population, this was a randomized, multicenter study, but it was a US-only population. There was also some imbalance in the number of visits between arms, so the combination arm was seen more frequently than the arm that got osimertinib alone. Now, the imaging assessments were no different, but obviously this could lead to potential confounding, at least in timing of awareness of potential side effects and and things being brought to the attention of investigators. So very promising data here, but because, you know, of this being a phase II study, this actually led to no changes in the guideline at this time. Brittany Harvey: Understood. Yes, as you mentioned prior, it's important to understand the full body of evidence and to review the trials even when it doesn't impact the recommendations. Dr. Joshua Reuss: And I will say that, you know, there is an ongoing phase III study looking at a very similar combination. It's the phase III ECOG-ACRIN trial of the combination of osimertinib plus bevacizumab versus osimertinib alone in this specific population. So, you know, I think we will see phase III–level data for a combination of VEGF with osimertinib, but again, promising phase II data that did not lead to a change in the recommendation at this time. Brittany Harvey: Absolutely. We'll look forward to that ongoing trial to learn more about combination in this patient population. So then moving to that second patient population that you mentioned earlier where the panel reviewed evidence, what is the updated evidence and recommendation for patients with NRG1 fusions? Dr. Joshua Reuss: Yeah, so this was an exciting update that we made more recently with this unique iteration of the living guidelines. So, NRG1 fusions, this is perhaps a newer kid on the block in terms of driver alterations that has been known to be identified in non–small cell lung cancer among other solid tumors. It is very rare, occurring in less than 1% of solid tumors, but something that we know is a unique oncogenic pathway that can lead to oncogenesis and cancer development, including in non–small cell lung cancer. So up until now, unfortunately, there have not been targeted therapies that target this unique alteration. It's somewhat different than other driver alterations where there's a top-level signaling change in a protein. This is more of a ligand alteration that then alters, that then enables activation of more classical pathways, but again, through upregulation of a unique ligand. So a slightly different pathway but something that we know should be able to be targeted to promote patient survival for those with NRG1 fusions. So the therapy here is a therapy called zenocutuzumab. It's an IgG1 bispecific antibody against HER2 and HER3. So it prevents the downstream dimerization and signaling that occurs as a result of this NRG1 fusion and upregulation of the NRG1 signal. This was, as you can imagine with a rare alteration, a large phase II registrational study that examined this in advanced solid tumors containing the NRG1 fusion. This is the NRG1 registrational trial. And this study enrolled patients with advanced solid tumors who had progressed on prior therapy. Patients were treated with zenocutuzumab 750 milligrams IV every two weeks. Among 158 response-evaluable solid tumor patients, the response rate was 30%, median duration of response of 11.1 months, and a median progression-free survival of 6.8 months. Now, in those with non–small cell lung cancer, that made up 93 response-evaluable patients, very similar outcomes there: a response rate of 29%, median duration of response of 12.7 months, and a median progression-free survival of 6.8 months. This therapy did appear to be well tolerated. The most common higher-grade emergent side effects - grade 3 or higher - were anemia occurring in 5% and elevated liver numbers occurring in 3%. So this is a subsequent-line study, so this led to the updated recommendation that clinicians may offer zenocutuzumab in the subsequent-line setting for patients with advanced non–small cell lung cancer who harbor NRG1 fusions. So I think this does speak toward the incredible importance of next-generation sequencing and molecular testing for patients, particularly to include testing that looks at the RNA. These large fusions can sometimes be very challenging to detect on DNA sequencing platforms alone, so it's important to, if you have a high level of suspicion for an alteration like this, perhaps some of the mucinous adenocarcinomas where it's been challenging to find a driver alteration, and it's someone who is a never-smoker, really would want to include molecular testing that assesses the RNA level and not just the DNA. Brittany Harvey: Absolutely. It's important to have all the biomarkers available so that clinicians are able to use that to inform their decision-making. So then, given these changes in the guideline, what should clinicians know as they implement this latest living guideline update? And how do these changes impact patients? Dr. Joshua Reuss: Yeah, I think talking in reverse order of what we just discussed here, there is a new guideline update for NRG1 fusions. So I think making sure that that's being evaluated, that clinicians are testing for that and really looking for that result that should be incorporated in in most next-generation large sequencing assays to get that result, but it's very important that that is not overlooked now that we do have a therapy that's available in the subsequent-line setting, though it is important to note that patients with NRG1 fusions, at least the limited data that there is suggests that the efficacy to standard chemoimmunotherapy regimens is overall poor. So physicians unfortunately might be facing this question for second-line therapy in patients with NRG1 fusions sooner rather than later. For the former, for EGFR-altered non–small cell lung cancer and how do we incorporate VEGF-containing regimens into these patients? Our guideline top-level update did not change based off of review of this new study, but it's important for clinicians to know what other combinations may exist. You know, there are phase III studies looking at this combination in the frontline setting. And of course, there is data on other bispecific molecules that incorporate VEGF in the subsequent-line setting, particularly a combination that includes the VEGF/PD-1 bispecific antibody ivonescimab that's being studied in the HARMONi-A trial for patients with EGFR-mutated advanced non–small cell lung cancer, for which we hope to get some more definitive data in the coming months. Brittany Harvey: Definitely. And then you've just mentioned a few ongoing trials where we're looking for evidence to inform future updates. But thinking beyond that, into the future, what is the panel examining for future updates to this living guideline? Dr. Joshua Reuss: It's a very exciting time to be in the world of treating advanced non–small cell lung cancer, particularly patients with driver alterations, because there is so much evolving data that's changing our practice in real time, again highlighting the importance of these living guideline updates. I'd say there's many things that we're excited to see. You know, a lot of the combination regimens in EGFR-mutated non–small cell lung cancer for which there are approvals and current recommendations in our guideline, particularly osimertinib plus chemotherapy and amivantamab plus lazertinib - those are the two approved combination strategies in the front line - we are now seeing the emergence of overall survival data for those combinations. So obviously that is something that's going to be very important for the committee to review and incorporate into guideline updates. There are several new therapies coming down the road for other driver populations. We recently saw an approval for taletrectinib for ROS1 fusion–positive non–small cell lung cancer, so it's going to be important that the committee reviews the data and the publications regarding that therapy. And then there are other novel therapies that we're looking to see updated data on. There are multiple antibody-drug conjugates, which take the potent power of a chemotherapy molecule and attempt to make that targeted with an antibody targeting to a unique feature on the cancer cell. And there are several antibody-drug conjugates that are in development at various levels of promise in this space, particularly in EGFR-mutated non–small cell lung cancer, and I anticipate seeing some emerging data for that coming up in the near future as well. So really, lots to be excited in the space and lots for our committee to review to give guidance on so that these patients can really receive the top-level care wherever they are being treated in the country and throughout the world. Brittany Harvey: Yes, we'll await this new data to continue to provide optimal options for patients with stage IV non–small cell lung cancer with driver alterations. So, Dr. Reuss, I want to thank you so much for your work to rapidly and continuously update and review the evidence for this guideline and thank you for your time today. Dr. Joshua Reuss: Thank you so much. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines Podcast. To read the full guideline, go to www.asco.org/thoracic-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available on the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Today on Beating Cancer Daily, Saranne, founder of the ComedyCures Foundation and a Stage IV cancer survivor for over 30 years, shares fresh and creative ways to infuse fun and positivity into the chemotherapy experience. Drawing from her signature chemo comedy parties and inspired by the joyful outlook of fellow survivors like Leah, Saranne encourages listeners to create tangible lists of things that could brighten up their chemo sessions. She explores the transformative effects of giving, building camaraderie with chemo buddies, engaging with playful gifts or small acts of kindness, and emphasizes the importance of setting mental boundaries to keep chemo from overshadowing daily life. Saranne also weaves in insights from behavioral science, sharing simple psychological tools and practical strategies to make the chemotherapy process less daunting and more enjoyable, revealing how laughter, connection, and intentional joy can become powerful medicine.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne and breast cancer survivor Missy Hall bring a lighthearted perspective to living as cancer survivors. They discuss Missy's recent comedy show, sharing the humorous challenges of balancing a late-night performance with the early morning recording. As they delve into laughter-inducing strategies for dealing with insomnia and anxiety, Saranne and Missy share their unique self-cheering and singing habits, highlighting how humor and joy play a vital role in their survivorship. Join them as they explore the power of laughter and find moments of happiness amid their cancer journey.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

Today on Beating Cancer Daily, Saranne discusses the importance of letting go of the past and finding ways to unburden yourself from past hurt and trauma. Drawing from her own experience, Saranne shares how she confronted the emotional challenges that surfaced during her cancer treatment and offers insights into therapeutic approaches to navigate the complexities of the past. Tune in as Saranne provides practical techniques for finding humor and releasing emotional burdens, ultimately empowering listeners to live their best lives free from the weight of the past. Join us as we explore the transformation from pain to strength and discover the positive impact of unburdening oneself.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne 

In today's episode, Saranne delves into a lighthearted and inspirational story submitted by Yael, a Stage IV melanoma survivor. The story involves a comedic encounter with an unexpected earthquake while traveling for work in Mexico. Saranne shares this charming and humorous tale to spark a conversation about finding humor and strength in the face of adversity. Join us as we explore Yael's resilience and discover the power of laughter in overcoming life's challenges. Prepare for a heartwarming and laughter-filled episode as we celebrate resilience and triumph over adversity.Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries on 7 continents and has over 365 original daily episodes hosted by Stage IV survivor Saranne Rothberg!   To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne