Podcasts about stage iv

In this heartfelt conversation, Saranne and Missy Hall come together to share their experiences and emotions surrounding Missy's cancer journey. With vulnerability and humor, Missy opened up about her recent illness and the challenges she faced post-radiation. As they discuss the ups and downs of recovery, Saranne offers support and encouragement, reminding Missy to prioritize self-care and embrace the healing process. Join Saranne and Missy as they navigate the complexities of life after cancer, finding strength and solace in their shared stories.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg.To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_SuggestionsTo sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

In this empowering episode, Saranne, a Stage IV cancer survivor, shares her journey and the powerful strategy that helped her envision a life without cancer. Join Saranne as she encourages listeners to tap into their multi-sensory imagination and design their cancer-free lives. Through her inspiring words, Saranne reminds us that we can shape our destinies and invites us to share our visions with her at ComedyCures.org. In this thought-provoking episode, prepare to embrace the possibility of a miraculous life beyond cancer.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

Today on Beating Cancer Daily, Saranne unveils the heartwarming and creative concept of "Stones of Happiness." Having conquered Stage IV cancer, Saranne deeply values the power of spreading joy and positivity. Inspired by a unique initiative from a library in Poland, she explains how painting and sharing personalized stones can bring unexpected happiness to others. Listen as she details the therapeutic benefits of this project and offers rock-themed humor to lighten the mood. Get inspired to spread love and compassion one stone at a time as we continue our journey of beating cancer daily together.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

Welcome to Beating Cancer Daily with Saranne, where we find humor and joy in the face of adversity. As a Stage IV cancer survivor for over 30 years, Saranne shares her unique strategies for coping with stress and finding moments of laughter. In this episode, Saranne reveals one of her craziest tactics: turning her frustrations into rock operas or traditional operas. Join her as she encourages listeners to embrace their inner diva and release stress through the power of song. Get ready to laugh, learn, and lighten up as we navigate the ups and downs of life with cancer.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne

In today's episode, Saranne shares her experience of incorporating cancer treatment into her busy schedule. She discusses the practice of micro-pausing between activities, which helped her stay present and manage the overwhelming thoughts about cancer. Saranne encourages listeners to try this technique and shares how it gave her incredible energy throughout the day. Join us as we explore the power of pausing and its impact on living our best days.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Today on Beating Cancer Daily, Saranne welcomes Jacqui Bryan for a thoughtful exploration of social jet lag, a growing phenomenon impacting wellness, especially for cancer survivors and caregivers. Together, they focus on how circadian misalignment between work, social commitments, and biological rhythms can disrupt sleep, influence nutrition, and increase disease risk, including the development of chronic inflammation. Saranne shares her own experiences, drawing on energy from social interactions and routine challenges, while Jacqui brings a scientific perspective, detailing the importance of maintaining healthy schedules. The conversation weaves humor, practical tips, and an encouraging call to awareness as they discuss actionable strategies for improving sleep hygiene and self-care, paving a path for healthier living and recovery for those facing cancer, including Stage IV. Jacqui Bryan is a certified health coach, functional medicine expert, whole health educator, and registered nurse. With over twenty years as a cancer survivor and extensive experience helping individuals improve their routines, Jacqui delivers evidence-based insights into sleep, nutrition, and lifestyle approaches for healing and wellness. Her deep understanding of circadian rhythms and holistic health makes her a knowledgeable guide for listeners seeking scientifically informed, realistic advice. "The more misaligned these clocks are, the higher our odds are of developing certain diseases." ~Jacqui Bryan Today on Beating Cancer Daily:·     Social jet lag stems from mismatches between work, social, and biological clocks, impacting sleep and overall health·     Consistent routines for sleep and eating help regulate circadian rhythms and support healing·     Screen time and blue light exposure at night can suppress melatonin production, making sleep more difficult·     Chronic social jet lag is linked to inflammation and increased risk of psychiatric, metabolic, and chronic illnesses·     Physical activity and exposure to natural light during the day help restore and support healthy circadian rhythms·     Heavy meals, alcohol, caffeine, and even chocolate close to bedtime can disrupt sleep quality·     Keeping a self-care schedule and journal can boost motivation by linking behaviors to positive feelings·     Self-awareness and habit stacking are practical ways to implement gradual change, improving daily wellness for cancer survivors and caregivers Resources Mentioned:ComedyCures Foundation ComedyCures free laugh line: 1-888-8 HA HA HA HA Guest Contact Information: Jacqui Bryan 2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. 

Featuring an interview with Dr Stacey A Cohen, Dr Arvind Dasari and Dr Christopher Lieu, including the following topics: Biological Principles Underlying Circulating Tumor DNA (ctDNA) Molecular Residual Disease (MRD) Testing in Colorectal Cancer (CRC) — Dr Cohen (0:00) Potential Utility of ctDNA Testing to Identify Patients with Localized CRC Who Might Benefit from Treatment De-escalation or Escalation — Dr Lieu (17:44) Role of ctDNA Analysis in the Management of Metastatic CRC – Dr Dasari (36:16) Clinical Investigator Survey Results (56:06) Case: A woman in her early 40s with mismatch repair-proficient/microsatellite-stable (MSS), low-risk Stage II colon cancer — Dr Lieu (1:23:05) Case: A woman in her early 70s with microsatellite instability-high Stage III colon cancer with a BRAF mutation — Dr Cohen (1:26:06) Case: A man in his mid 40s with metastatic CRC — Dr Dasari (1:31:57) Case: A man in his early 50s with low-risk Stage III colon cancer — Dr Lieu (1:37:54) Case: A man in his early 30s with MSS, high-risk Stage II CRC — Dr Cohen (1:50:17) Case: A woman in her early 50s with metastatic CRC — Dr Dasari (1:52:05) Case: A man in his early 60s with Stage IV colon cancer — Dr Lieu (1:56:05) CME information and select publications

In this episode, Saranne shares her personal journey of overcoming cancer and the power of changing her cancer voice. From the moment she received her diagnosis, Saranne realized the impact that self-talk can have on her mindset and resilience. Through her own determination and practice, she transformed her fear into strength, ultimately becoming a stage four cancer survivor. Join Saranne as she reveals the simple yet profound technique that helped her quiet the negative voice and make room for joy and gratitude in her life.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

On February 18, 2026, an Osceola County judge sentenced 70-year-old Richard Ferguson to 37 years in prison following a 2023 crash that claimed the lives of a grandmother and her three grandchildren. Despite not being behind the wheel, Ferguson was convicted of four counts of manslaughter for allowing his unlicensed 15-year-old son to drive the vehicle involved in the high-speed collision. In this episode, we explore:The Case Details: A look back at the September 2023 Poinciana crash and the evidence that led to a father's conviction.The "Mandatory Minimum": Why Judge Wayne Wooten denied a "downward departure" despite Ferguson's health battle with Stage IV cancer.Parental Liability: The legal argument behind charging a parent with manslaughter when they aren't the driver.The Victims' Impact: Powerful courtroom testimony from Sabrina Hernandez, who lost her mother and three children in the tragedy.The Teen's Sentence: Discussion on the plea deal that keeps the son in juvenile custody until age 19.Key Takeaway: This case serves as a massive warning to parents regarding the legal responsibilities of vehicle ownership and the life-altering consequences of "negligent entrustment" in the state of Florida.

Today on Beating Cancer Daily, Saranne teams up with Jacqui Bryan to discuss the intricate gut-brain axis, particularly its significance for cancer patients and its treatments. They explore how treatments can disrupt gut health and affect brain function, offering insights into empowering oneself through understanding this vital connection. Jacqui elaborates on the gut-brain axis as a complex communication network linking the digestive and central nervous systems, emphasizing its impact on digestion, immunity, mood, and stress.Jacqui Bryan is a certified nutrition specialist, functional medicine expert, and whole health educator with over 22 years of cancer survivorship. As a health coach and registered nurse, Jacqui brings a wealth of experience guiding individuals toward optimal health, focusing on diet and lifestyle principles to support healing and well-being.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode, Saranne, the founder of the Comedy Cures Foundation, discusses the importance of support and understanding when facing a cancer diagnosis. She shares her experiences and highlights an article by Jan C. Dunn, emphasizing the three H's: help, hear, and hug. Saranne encourages listeners to communicate their needs to their support circle and reminds them that they sometimes need a listening ear or a comforting hug. Tune in as Saranne explores the power of laughter and the role of caregivers in the cancer journey.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this engaging episode of Beating Cancer Daily, Saranne humorously tackles the concept of procrastination, exploring how it intersects with the experiences of those affected by cancer.With her characteristic blend of warmth and authenticity, Saranne candidly shares personal anecdotes, weaving in her journey with Stage IV cancer and delving into procrastination's psychological underpinnings. The episode unpacks the different types of procrastinators, offering insights into how recognizing these behaviors can lead to overcoming them. Saranne also reflects on how her past experiences influence her current procrastination patterns while providing strategies to combat this common challenge in her pursuit of optimal health.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne shares how she found inspiration in quotes and stories, using them when bad news or difficult days hit. Despite the challenges she faced, Saranne discovered strength and resilience through the words of Arnold Schwarzenegger and talked about the importance of surrounding oneself with stories of cancer survivors, visualizing a life beyond the daily grind, and committing to a 365-day battle against cancer. Saranne also highlights the power of injecting humor into the journey and shares their experience with starting a chemo comedy party. Join Saranne as she inspires motivation and strength in the face of adversity.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne focuses on self-improvement and nurturing relationships. She explores the idea of seeking feedback from loved ones and partners as a means of personal growth and shares stories of individuals who have taken this approach and its positive impact on their relationships. Saranne also emphasizes the importance of avoiding criticism and sarcasm to create a supportive and nurturing environment. Join Saranne as she delves into the topic of self-improvement by seeking feedback and fostering healthy relationships.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

 Today on Beating Cancer Daily, Saranne welcomes functional medicine expert Jacqui Bryan to explore the science and humor behind seed cycling, a food first approach to hormone balance for both women and men. Known for supporting menstrual cycles, fertility, menopause, and men's health, seed cycling pairs specific seeds with different phases of the menstrual cycle to naturally encourage hormonal balance. Saranne and Jacqui share personal anecdotes, debunk myths about phytoestrogens, and highlight the power of “food as medicine,” all while weaving in laughter as an essential tool for healing, inspired by Comedy Cures Foundation. They cover practical tips for integrating flax, pumpkin, sesame, and sunflower seeds into daily routines, and why small dietary shifts can impact overall wellness for cancer survivors, thrivers, and anyone seeking a better quality of life. Jacqui Bryan is a certified nutrition specialist, whole health educator, certified health coach, registered nurse, and functional medicine expert. Her integrative approach has empowered countless individuals to become their own health detectives, embracing food-based strategies to manage chronic illness, enhance vitality, and support holistic healing. With decades of hands-on experience and personal survivorship, Jacqui combines evidence-based nutrition with compassionate coaching, making her insights both practical and inspiring. "Seed cycling may not work for everyone, but even if it doesn't work for the hormone balancing part...it's a nutrient-dense approach. Your body is going to be getting some benefits from it." ~Jacqui Bryan Today on Beating Cancer Daily:·     Seed cycling supports hormone balance using a rotation of flax, pumpkin, sesame, and sunflower seeds.·     This approach is beneficial for women experiencing menstrual irregularity, PMS, menopause, and even polycystic ovary syndrome (PCOS).·     Men can benefit from seed cycling through improved fertility, prostate health, and overall nutrient intake.·     Phytoestrogens in seeds act differently from pharmaceutical estrogen, and moderate intake is generally safe, even for those with hormone-driven cancers, under medical guidance.·     A 28-day seed cycling rotation can be adapted for anyone, regardless of gender or menopausal status.·     Quality nutrition, blood sugar regulation, and anti-inflammatory benefits make seeds a smart addition for cancer prevention and survivorship.·     Embracing laughter and stress reduction is as critical for hormonal health as nutritional changes.·     Always consult healthcare providers before implementing new dietary practices, especially for those with complex medical histories. 2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne   

In this episode, Candice sits down with Mark Ruegg, a stage four pancreatic cancer thriver, holistic healing advocate, and co-founder of Boom Mar Productions. Mark shares how his life took an unexpected turn from building a successful career in child wrangling and production services to facing a terminal cancer diagnosis with only months to live. In this episode, they discuss:Mark's unexpected stage four pancreatic cancer diagnosis and prognosisHow surrender and trust became a foundation for healingThe role of meditation and Dr. Joe Dispenza's work in his recoveryWhy the body cannot heal in fight or flight modeThe importance of nutrition, movement, and lowering inflammationHow belief and positivity became essential ingredients in his healing journeyMark's mission to help others see that healing is possible This inspiring conversation is a powerful reminder that when belief and possibility outweigh the prognosis, healing, purpose, and hope can emerge in extraordinary ways. About Mark:Mark Ruegg is a Stage IV pancreatic cancer thriver, holistic healing advocate, and co-founder of BuMar Productions, a leading child wrangling and production services referral agency trusted by Disney, Walmart, and Target. Defying a grim prognosis through advanced medicine, spiritual faith, and transformative holistic practices, Mark inspires cancer patients and caregivers to believe healing is possible. With nearly 20 years in advertising and a passion for empowering others, he shares a message of hope, resilience, and active healing. Mark's story was recently featured in the Seena Magowitz Foundation's "Warriors" series, highlighting his commitment to helping others embrace their power to heal. Facebook: https://www.facebook.com/markallenrueggIG: https://www.instagram.com/markallenruegg/Substack: https://substack.com/@markruegg-----Connect with Candice Snyder!Website: https://www.podpage.com/passion-purpose-and-possibilities-1/Facebook: https://www.facebook.com/candicebsnyder?_rdrPassion, Purpose, and Possibilities Community Group: https://www.facebook.com/groups/passionpurposeandpossibilitiescommunity/Instagram: https://www.instagram.com/passionpurposepossibilities/LinkedIn: https://www.linkedin.com/in/candicesnyder/Shop For A Cause With Gifts That Give Back to Nonprofits: https://thekindnesscause.com/Fall In Love With Artists And Experience Joy And Calm: https://www.youtube.com/@movenartrelaxation

In this episode, Saranne explores the power of surprise in the cancer ecosystem. Drawing from personal experiences and research, Saranne discusses how surprises can bring joy and disrupt the typical cancer journey. From surprising others in waiting rooms to using surprise as a coping strategy, Saranne emphasizes the importance of thinking differently and embracing surprise in our everyday lives.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

On today's episode of Beating Cancer Daily, Saranne engages in a heartfelt and humorous conversation with Missy Hall, a talented comedian who has brought laughter to countless audiences and embarked on her cancer journey. With a unique perspective on life and a knack for finding humor in the most unexpected places, Missy exemplifies the power of comedy in the face of adversity. Join us as we delve into Missy's experiences, from her diagnosis to her triumphant return to the stage, and discover how she navigates the delicate balance between cancer and comedy.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne shares valuable insights on the mind-body connection and its impact on health, particularly in relation to cancer treatment. She emphasizes the importance of practices like yoga, meditation, laughter, humor, positivity, and play in shifting our mindset and actions toward cancer. She also discusses groundbreaking research that shows how thoughts and emotions can affect gene expression and overall well-being. She shares her personal experience of using these practices to overcome cancer and encourages listeners to explore the mind-body connection for themselves. Saranne hopes that this bite-sized podcast serves as a story starter for listeners to delve deeper and adopt these practices. So, let's open our hearts and minds to the possibility of being great healers of our own beings and start our journey towards better health.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne invites listeners to take a fun break from their daily routines. In this lighthearted discussion, Saranne encourages everyone to imagine who would play them in a biopic of their life. Whether it's a major superstar or someone unexpected, casting yourself in a movie can be a delightful exercise that allows you to think about life in a broader context.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne delves into the harmful phenomenon of 'doom scrolling' - the compulsive act of consuming a steady stream of negative news. This tendency, she highlights, can amplify anxiety and even spur symptoms akin to post-traumatic stress disorder. Saranne shares a personal account of caring for someone caught in the doom-scrolling spiral, highlighting its detrimental effects on their overall well-being.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne shares her journey of overcoming challenges through the power of fun and play. From her own experience with cancer surgeries, radiation treatments, and chemotherapy, she emphasizes the importance of incorporating laughter and playfulness into daily life to build resilience and prevent burnout. Saranne highlights the transformative power of humor and offers three key takeaways: prioritize fun, assign a day for laughter and joy, and infuse positivity into every aspect of life. Join Saranne as she explores the incredible impact of fun and play in overcoming adversity.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Today on Beating Cancer Daily, Saranne brings together decades of survivorship wisdom and the power of laughter to spotlight the transformative potential of functional nutrition for cancer thrivers. After launching the ComedyCures Foundation from the chemo chair during her first treatment for Stage IV cancer, Saranne has built a community focused on self-care and empowerment. In this episode, she is joined by recurring expert Jacqui Bryan to unpack what makes functional nutrition both fun and foundational, especially for those facing cancer. Together, they explore root cause resolution, whole-body systems, and practical strategies for self-advocacy in health, always with a dose of playfulness and resilience. Jacqui Bryan joins as a certified nutrition specialist, registered nurse, whole health educator, and certified health coach who is now a doctoral candidate in integrative nutrition. With two master's degrees, one in functional nutrition, Jacqui's passion for personalized, evidence-based care shines as she shares her journey from collegiate athlete and RN to cancer survivor, functional nutritionist, and teacher. Through over 100 episodes with Saranne, Jacqui has empowered listeners to engage with self-care, holistic healing, and tailored nutrition strategies. "Functional nutrition looks at the root causes of disease rather than merely treating a symptom...functional medicine looks at root cause resolution, and it is a personalized approach, which is why I love it." ~Jacqui Bryan Today on Beating Cancer Daily:·     Functional nutrition emphasizes root cause resolution over treating isolated symptoms.·     A personalized, individualized approach is key, nutrition plans are tailored to each person's genetics, lifestyle, and environment.·     Medical professionals are not immune; survivorship brings reckoning, self-investigation, and the opportunity for empowerment.·     Functional nutrition considers not just diet, but sleep, stress, exercise, and social connection as part of holistic care.·     There is a shift away from the "band-aid" approach, focusing on supporting the body's systems and restoring balance.·     Self-care is foundational, organ health, immune support, and nutritional choices all contribute to cancer recovery and prevention.·     Community and therapeutic relationships empower patients to take ownership of their health journey.·     Environmental toxins and processed foods, including microplastics and chemical additives, are highlighted as key factors influencing cancer risk and recovery. 2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne    

In this episode, Saranne discusses the importance of happiness and joy in cancer survival. She shares a personal story about her battle with Stage IV cancer and how it led her to create the Comedy Cures Foundation, a non-profit organization that brings happiness and joy to others. Saranne also discusses a question that was posed to her during her illness: Would she prefer to be happy, smart, or rich? She reflects on her answer and how it applies to her daughter's life.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

On today's episode of Beating Cancer Daily, Saranne engages in a heartfelt and humorous conversation with Missy Hall, a talented comedian who has not only brought laughter to countless audiences but has also embarked on her own cancer journey. With a unique perspective on life and a knack for finding humor in the most unexpected places, Missy exemplifies the power of comedy in the face of adversity. Join us as we delve into Missy's experiences, from her diagnosis to her triumphant return to the stage, and discover how she navigates the delicate balance between cancer and comedy.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode, Saranne dives into a crucial topic - your mood! We all know being a caregiver is far from easy, sometimes even more challenging than being a patient. So, it's incredibly important to foster effective communication between patients and caregivers. That's where the concept of mood temperature comes in. It's a tool that helps patients to express their emotional state to their caregivers. Once aware, caregivers can then step in with the right kind of support, be it a comforting hug, practical help, or simply lending a sympathetic ear tailored to the patient's mood.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Featuring an interview with Dr Kathleen N Moore, including the following topics: Overview of the mechanism of action and pharmacology of antibody-drug conjugates (ADCs) (0:00) Comparing toxicities of conventional chemotherapy and ADCs (6:26) Potential of ADCs as maintenance therapy for ovarian cancer (11:35) Treatment based on platinum sensitivity and homologous recombination-deficiency status (15:10) Case: A woman in her mid 70s presenting with Stage IV ovarian cancer receives raludotatug deruxtecan (18:46) Case: A woman in her mid 60s with relapsed/refractory ovarian cancer receives mirvetuximab soravtansine (41:22) Case: A woman in her early 70s with relapsed/refractory ovarian cancer receives multiple ADCs in clinical trials (45:57) CME information and select publications

In this episode, Saranne explores the power of hobbies during cancer treatment. Drawing from personal experience and research, Saranne discusses the benefits of engaging in leisure activities while undergoing cancer treatment, including stress reduction, improved brain health, and enhanced memory. She also invites listeners to share their thoughts and hobbies, encouraging them to try new activities or indulge in the ones they love. Tune in to discover the transformative impact of hobbies on emotional well-being and find inspiration for your own journey.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode of Beating Cancer Daily, Saranne shares some insights from a movie she recently enjoyed called The Swimmers. One phrase from the film really stuck with her: "find your lane, swim your race." Saranne believes this is a potent message, especially for folks navigating the choppy waters of cancer, who sometimes feel expected to handle their situation in a specific way. She underlines how crucial it is to chart your own course through your cancer journey and, surprisingly, the personal growth opportunities it might spark.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode, Saranne shares three uncomplicated but potent cancer-busting reminders that listeners can incorporate into their daily routines. These reminders encourage individuals to pause for a moment to laugh, stretch, or breathe. By embedding these micro habits into their daily regimen and making them a regular practice, listeners have the opportunity to elevate their mood, diminish stress, and enhance their overall health and well-being.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Today on Beating Cancer Daily, Saranne welcomes functional medicine expert Jacqui Bryan for an in-depth conversation about the growing trend of IV supplement drips, with a particular focus on NAC (N-acetylcysteine) and its relevance for those facing a cancer diagnosis. Together, they break down what NAC actually is, the distinction between obtaining it from food versus supplements, and the safety considerations for cancer patients, especially those with scarred veins or a history of intense treatments like Stage IV chemotherapy. Jacqui shares personal anecdotes and clinical wisdom, examining whether these trendy infusions offer real benefits or if a well-chosen diet might serve just as well—minus the needles. Jacqui Bryan is a certified nutrition specialist, whole health educator, health coach, and registered nurse, revered for her functional medicine approach to cancer care and recovery. Drawing on her expertise in nutrition and integrative health, Jacqui helps individuals navigate the complex intersection of supplements, food, and healing, always with a focus on safe, evidence-based recommendations for those living with or beyond cancer. "My first choice really is having this high-quality diet that will help you get similar benefits... it's not exactly the same, but NAC does have benefits for a certain population."  ~Jacqui Bryan Today on Beating Cancer Daily:·     IV NAC supplementation is gaining attention, but it's important to understand who truly benefits and the risks involved.·     NAC is both a prescription medication and a supplement, most often used to support liver function and to thin mucus in hospitals.·     The primary benefit of NAC supplementation or cysteine-rich foods is aiding the production of glutathione, a master antioxidant for cellular protection.·     Protein-rich foods like poultry, fish, eggs, and plant-based options such as whole grains, legumes, and seeds can provide cysteine for most people.·     Intense supplementation (including IV form) may only be necessary for those with specific deficiencies or medical needs after consulting a provider.·     Those undergoing active cancer treatment, especially with damaged veins from chemotherapy, may find dietary approaches more comfortable and practical than IV drips.·     NAC carries potential safety considerations, including interactions with medications and certain conditions such as bleeding disorders or asthma; medical oversight is essential.·     Most individuals eating a healthy diet without specific medical concerns do not need to supplement with NAC. 2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne   

The concept of 'entertaining your cancer' might sound odd at first, but it truly showcases the strength of our thoughts and feelings concerning our health. Saranne made the choice to confront her cancer with positivity and a good dose of humor, which helped reduce stress and presented a unique coping mechanism for her illness. Although this approach might not resonate with everyone, it serves as a reminder that there isn't just one correct method to overcome cancer. Everyone's journey is different and unique.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this empowering episode, Saranne and Missy Hall come together to discuss the intersection of faith, resilience, and comedy in the face of adversity. Saranne, a Stage IV cancer survivor, shares her journey of overcoming the odds, while Missy, a comedian and cancer patient, brings her unique perspective on finding humor in the midst of a cancer diagnosis. Join these two incredible women as they delve into the power of laughter, the importance of self-care, and the strength that comes from embracing both the funny and the challenging moments in life.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Dr. Sonam Puri discusses the full update to the living guideline on stage IV NSCLC with driver alterations. She shares a new overarching recommendation on biomarking testing and explains the new recommendations and the supporting evidence for first-line and subsequent therapies for patients with stage IV NSCLC and driver alterations including EGFR, MET, ROS1, and HER2. Dr. Puri talks about the importance of this guideline and rapidly evolving areas of research that will impact future updates. Read the full living guideline update "Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.0" at www.asco.org/thoracic-cancer-guidelines TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/thoracic-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02822    Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today I'm interviewing Dr. Sonam Puri from Moffitt Cancer Center, co-chair on "Therapy for Stage IV Non-Small Cell Lung Cancer with Driver Alterations: ASCO Living Guideline, Version 2026.3.0." It's great to have you here today, Dr. Puri. Dr. Sonam Puri: Thanks, Brittany. Brittany Harvey: And then just before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Puri, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then, to dive into the content that we're here today to talk about, Dr. Puri, this living clinical practice guideline for systemic therapy for patients with stage IV non-small cell lung cancer with driver alterations is updated on an ongoing basis. So, what data prompted this latest update to the recommendations? Dr. Sonam Puri: So Brittany, non-small cell lung cancer is one of the fastest-moving areas in oncology right now, particularly when it comes to targeted therapy for driver alterations. New data are emerging continuously from clinical trials, regulatory approvals, real-world experience, which is exactly why these are living guidelines. The goal is to rapidly integrate important advances as they happen, rather than waiting for years for a traditional update. Since the last full update of the ASCO Stage IV Non-small Cell Lung Cancer Guideline with Driver Alterations published in 2024, there have been seven new regulatory approvals and changes in first-line therapy for some driver alterations. [This version] of the "Stage IV Non-small Cell Lung Cancer Guidelines with Driver Alterations" represents a full update, which means that the panel reviewed and refreshed every applicable section of the guideline to reflect the most current evidence across therapies including sequencing and clinical decision-making. This is to ensure that clinicians have up-to-date practical guidelines that keep pace with how quickly the field is evolving. Brittany Harvey: Absolutely. As you mentioned, this is a very fast-moving space and this full update helps condense all of those versions that the panel reviewed before into one document, along with additional approvals and new trials that you reviewed during this time period. So then, the first aspect of the guideline is there's a new overarching recommendation on biomarker testing. Could you speak a little bit to that updated recommendation? Dr. Sonam Puri: Yeah, definitely. So the panel has discussed and provided recommendations on comprehensive biomarker testing and its importance in all patients diagnosed with non-small cell lung cancer. Ideally, biomarker testing should include a broad-based next-generation sequencing panel, rather than single-gene tests, along with immunohistochemistry for important markers such as PD-L1, HER2, and MET. These results really drive treatment decisions, both in frontline settings for all patients diagnosed with non-small cell lung cancer and in subsequent line settings for patients with non-small cell lung cancer harboring certain targetable alterations. Specifically in the frontline setting, it helps determine whether a patient should receive upfront targeted therapy or immunotherapy-based approach. We now have strong data that shows that complete molecular profiling results before starting first-line therapy is associated with better overall survival and actually more cost-effective care. Using both tissue and blood-based testing can improve likelihood of getting actionable results in a timely way, and we've also provided guidance on platforms that include RNA sequencing, which are specifically helpful for identifying gene fusions that might be otherwise missed with other platforms. On the flip side, outside of a truly resource-limited setting, single-gene PCR testing really should not be routine anymore. This is what the panel recommends. It's less sensitive and inefficient and increases the risk of missing important actionable alterations. Brittany Harvey: Understood. I appreciate you reviewing that recommendation. It really helps identify critical individual factors to match the best treatment option to each individual patient. So then, following that recommendation, what are the updated recommendations on first-line therapy for patients with stage IV non-small cell lung cancer with a driver alteration? Dr. Sonam Puri: Since the last full update in 2024, there have been four additional interim updates which were published across 2024 and 2025. Compared to the last version, there have been several updates which have been included in this full update. One of the most important shifts has been in first-line treatment of patients with non-small cell lung cancer harboring the classical, or what we call as typical, EGFR mutation. The current version of the recommendation is based on the updated survival data from the phase III FLAURA2 and MARIPOSA studies, based on which the panel recommended to offer either osimertinib combined with platinum-pemetrexed chemotherapy or the combination of amivantamab plus lazertinib in the first-line treatment of classical EGFR mutations. And these recommendations, as I mentioned, are grounded in the results of the FLAURA2 and MARIPOSA trials, both of which demonstrated improvement in progression-free survival and overall survival compared to osimertinib alone in patients with common EGFR mutations. That being said, the panel actually spent significant time discussing the toxicities associated with these treatments as well. These combination approaches come with higher toxicity, longer infusion time, increased treatment frequency. So while combination therapy is now recommended as preferred, the panel has recommended that osimertinib monotherapy remains a reasonable option, particularly for patients with poor performance status and for those who are not interested in treatment intensification after knowing the risks and benefits. Brittany Harvey: Absolutely. It's important to consider both those benefits and risks of those adverse events that you mentioned to match appropriately individualized patient care. So then, beyond those recommendations for first-line therapy, what is new for second-line and subsequent therapies? Dr. Sonam Puri: So this is a section that saw several major updates, particularly again in the EGFR space. The first was an update on treatment after progression on osimertinib for patients with classical EGFR mutation. Here the panel recommends the combination of amivantamab plus chemotherapy, and this recommendation was based on the phase III MARIPOSA-2 trial, which compared amivantamab plus chemotherapy with chemotherapy alone with progression-free survival as the primary endpoint. The study met its primary endpoint, showing an improvement in median PFS with the combination of amivantamab plus chemotherapy compared to chemotherapy alone. And as expected, the combination was associated with higher toxicity. So, although the panel recommends this regimen, the panel emphasizes that patients should be counseled on the side effects which may be moderate to severe with the combination therapy approach. In addition, a new recommendation was added for patients who are not candidates for amivantamab plus chemotherapy. In those cases, platinum-based chemotherapy with or without continuation of osimertinib may be offered, and the option of continuing osimertinib with chemotherapy was recommended and supported by data from a recently presented phase III COMPEL study, which randomized 98 patients with EGFR exon 19 deletion or L858R-mutated advanced non-small cell lung cancer who had experienced no CNS progression on first-line osimertinib, and these patients were randomized to receive platinum-pemetrexed chemotherapy with osimertinib or placebo. Although this study was small, it demonstrated a PFS benefit with continuation of osimertinib with chemotherapy, and this approach may be appropriate for patients without CNS progression who prefer or require alternatives to more intensive treatment strategies. Next was an update on options for patients with EGFR-mutated lung cancer after progression on osimertinib and platinum-based chemotherapy. Here the panel recommended that for patients whose disease has progressed after both osimertinib and platinum-based chemotherapy, a new drug known as datopotamab deruxtecan can be offered as a treatment option. And this treatment recommendation was based on evaluation of pooled data from the TROPION-Lung01 and TROPION-Lung05 study, in which in the pooled analysis about 114 patients with EGFR-mutant non-small cell lung cancer were treated with Dato-DXd, 57% of whom had received three or more prior lines of treatment, and what was observed was an overall response rate of 45% with a median duration of response of 6.5 months. So definitely promising results. Next, we focused on updates to subsequent therapy options for patients with another type of EGFR mutation known as EGFR exon 20 insertion mutations. In this section, the panel added sunvozertinib as a subsequent line option after progression on platinum-based chemotherapy with or without amivantamab. Sunvozertinib is an oral, irreversible, and selective EGFR tyrosine kinase inhibitor with efficacy demonstrated in the phase II WU-KONG6 study conducted in Chinese patient population. In this study, amongst 104 patients with platinum-pretreated EGFR exon 20 mutated non-small cell lung cancer, the observed response rate was 61%. Staying in the EGFR space, the panel added a recommendation for patients with acquired MET amplification following progression on EGFR TKI therapy. In these situations, the panel recommended that treatment may be offered with osimertinib in combination with either tepotinib or savolitinib. As our listeners may know, MET amplification occurs in approximately 10% to 15% of patients with EGFR-mutated non-small cell lung cancer when they progress on third-generation EGFR TKIs, and detection of MET amplification is done with various methods, such as tissue-based methods like FISH, NGS, and IHC, as well as ctDNA-based NGS with variable cut-offs. Over the last few years, several studies have informed this recommendation. I'm going to be discussing some of them. In the phase II ORCHARD trial, 32 patients with MET-amplified non-small cell lung cancer after progression on first-line osimertinib were evaluated, where the combination of osimertinib plus savolitinib achieved an overall response rate of 47% with a duration of response of 14.5 months. More recently, the phase II SAVANNAH trial reported outcomes in 80 patients with MET-amplified tumors after progression on osimertinib, and in this patient population, the combination of savolitinib and osimertinib achieved an overall response rate of 56% with a median PFS of 7.4 months. And lastly, the phase II single-arm INSIGHT 2 trial assessed the efficacy of osimertinib plus tepotinib in patients with advanced EGFR-mutant non-small cell lung cancer who had disease progression following first-line osimertinib therapy. And in this study, in a cohort of 98 patients with MET-amplified tumors confirmed by central testing, the overall response rate with the combination was 50% with a duration of response of 8.5 months. So definitely informing this guideline recommendation. Next, we had an update on recommendation in patients with ROS1-rearranged non-small cell lung cancer. For patients with ROS1-rearranged non-small cell lung cancer, the panel recommended specifically for patients who progressed after first-line ROS1 TKIs, the addition of taletrectinib as a new option alongside repotrectinib. And this recommendation was based on analysis of the results of the TRUST-I and TRUST-II studies, which showed that amongst 113 tyrosine kinase inhibitor-pretreated patients, taletrectinib achieved a confirmed overall response rate of 55.8% with a median duration of response of 16.6 months and a median PFS of 9.7 months, a very promising agent. Finally, for patients with HER2 exon 20 mutated non-small cell lung cancer, the panel added two new oral HER2 tyrosine kinase inhibitors, zongertinib and sevabertinib, as options in addition to T-DXd and after exposure to T-DXd. These recommendations are based on early phase data from two trials: the phase I Beamion LUNG-01 study, which evaluated zongertinib, and the phase I/II SOHO-01 study that evaluated sevabertinib. In this study, zongertinib demonstrated an overall response rate of 71% in previously treated patients, with an overall response rate of 48% amongst patients who had received prior HER2-directed ADCs including T-DXd. Sevabertinib in its early phase study showed an overall response rate of 64% in previously treated but HER2 therapy-naive patients, and an overall response rate of 38% in patients previously exposed to HER2-directed therapy. The panel believes that both agents had manageable toxicity profile and represent meaningful new options for this patient population. Brittany Harvey: Certainly, it's an active space of research, and I appreciate you reviewing the evidence underpinning all of these recommendations for our listeners. So, it's great to have these new options for patients in the later-line settings. And given all of these updates in both the first and the later-line settings, what should clinicians know as they implement this latest living guideline update, and how do these changes impact patients with non-small cell lung cancer? Dr. Sonam Puri: Some great questions, Brittany. I think for clinicians when implementing this update, I think about two practical steps. First is reiterating the importance of comprehensive biomarker testing. That is the only way to identify key drivers and resistance mechanisms that we are now targeting. And second, picking a first-line strategy that balances efficacy and toxicity and patient preference for your specific patient. I think informed decision-making, shared decision-making is more important than any time right now. It has always been important, but definitely very important now. For patients, this guideline brings recommendations on more personalized treatment options for both first-line and post-progression settings, which potentially means better outcomes. But it is also very important for our patients to continue to have informed conversations about side effects, time commitment, and what matters most to them with their providers. The panel in this version of the guideline specifically acknowledges the real-world barriers that prevent patients from receiving guideline-concordant therapy, including challenges with access to comprehensive molecular testing and treatment availability, and the panel emphasizes on the importance of shared decision-making, and we provide practical discussion points to help clinicians navigate these conversations with the patient. In addition, the panel has also addressed common real-world clinical complexities, such as treating elderly or frail patients, managing multiple chronic conditions, considerations around pregnancy and fertility, and certain disease scenarios such as oligoprogression or oligometastatic disease. And where available, the guideline summarizes this existing data to support informed individual decision-making in these complex situations. Brittany Harvey: Shared decision-making is really paramount, especially with all of the options and weighing the risks and benefits and considering the individual circumstances of each patient that comes before a clinician. We've talked a lot about all of the new studies that the panel has reviewed, but what other studies or areas of research is the panel examining for future updates to this living guideline as it continues to be updated on an ongoing basis? Dr. Sonam Puri: Yes, definitely, so much to look forward to, right? Looking ahead, the panel is closely monitoring several rapidly evolving areas that are likely to shape future updates of the guideline. This includes emerging data from ongoing later-phase studies, particularly the studies that are evaluating these new targeted agents moving to earlier lines of therapy, alongside studies evaluating additional combination strategies or more refined approaches to treatment sequencing. We're also closely watching advances in biomarker testing, the evolving understanding of resistance mechanisms, development of new targets, and promising therapeutic agents. I think ultimately the living guideline exists to help clinicians and patients navigate this rapidly evolving field, and we would like to ensure that scientific advances are rapidly translated into better, more personalized patient care. Brittany Harvey: Definitely. We'll look forward to those updates from those ongoing trials and future areas of research that you mentioned to provide better options for patients with non-small cell lung cancer and a driver alteration. So I want to thank you so much for your work to rapidly and continuously update this guideline, and thank you for your time today, Dr. Puri. Dr. Sonam Puri: Thanks so much. Thanks so much for the opportunity. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/thoracic-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in the Apple App Store or the Google Play Store. There's also a companion episode with Dr. Reuss on the related living guideline on stage IV non-small cell lung cancer without driver alterations that listeners can find in their feeds as well. And if you've enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Dr. Joshua Reuss is back on the podcast to discuss the full update to the living guideline on stage IV NSCLC without driver alterations. He discusses the new evidence and how this impacts the latest recommendations on first-line and subsequent therapeutic options. Dr. Reuss emphasizes the need for shared decision-making between clinicians and patients. He shares ongoing research that the panel will review in the future for further updates to this living guideline, and puts the updated recommendations into context for clinicians treating patients with stage IV NSCLC. Read the full living guideline update "Therapy for Stage IV Non-Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2026.3.0" at www.asco.org/thoracic-cancer-guidelines" TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/thoracic-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02825    Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today I am interviewing Dr. Joshua Reuss from Georgetown University, co-chair on "Therapy for Stage IV Non-Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2026.3.0." It is great to have you back on the show today, Dr. Reuss. Dr. Joshua Reuss: Happy to be here, Brittany. Brittany Harvey: Just before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Reuss who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. Dr. Reuss, this living clinical practice guideline for systemic therapy for patients with stage IV non-small cell lung cancer without driver alterations is updated on an ongoing basis. So, what prompted this latest update to the recommendations? Dr. Joshua Reuss: Our committee is tasked with making routine updates to the living guidelines and really keeping them living, right? So, evaluating new data as it is coming in to see, is this practice changing? Is this data that should inform and potentially alter our guideline recommendations so that practitioners and other care providers could really make the best treatment decisions for their patients? So that is something that happens on a more routine basis, but periodically, we are tasked with performing a more comprehensive update of our guideline where we really evaluate every one of our point recommendations, the data associated with these recommendations, to be sure that these are up to date, these are comprehensive, and to see if we need to alter anything in the language of these updates. Brittany Harvey: Excellent. Thank you for providing that background. And yes, this is truly a comprehensive update that goes through all the latest literature. Given that, I would like to review what has changed and what is new in the recommendations. So, what are the updated recommendations on first-line therapy for patients with stage IV non-small cell lung cancer without driver alterations? Dr. Joshua Reuss: So there are two main guidelines that we recommend from this panel. One is a driver mutation-positive guideline and the other is a driver mutation-negative guideline. And I think on first blush, one might look at kind of the recent flurry of approvals and new data and say, well, all the excitement, you know, is in the driver mutation-positive guideline. But I would say that the driver mutation-negative guideline is equally as important and really has several unique challenges associated with it. You know, first and foremost is that there are really a multitude of regimens that can be considered for any one patient. And how to choose between one can be quite difficult and a stressful challenge that clinicians can have, particularly since there are really no randomized studies comparing these regimens in a head-to-head fashion. In addition, you know, these guidelines are really broken down by two key factors. One is disease histology, so namely squamous versus non-squamous histology. And the other is PD-L1 status, broken down into one of three tertiles: PD-L1 high, which is greater than or equal to 50% expression; PD-L1 low, which is 1% to 49% expression; and then PD-L1 negative or unknown. So what you are really looking at, if you do that math, is really six unique patient subpopulations where we need to make a recommendation on one of the multitude of treatment regimens that is approved. And what that means is you are oftentimes really looking at subset and sub-subset level data to help inform clinicians in their treatment decision making, which can be quite challenging because as those small subsets of data is more and more parsed, there are many confounders that can be interjected there. And so I think the committee is tasked with really quite a challenge in terms of how to really communicate and broadcast that data in a way that informs clinicians in making a decision on what is the right treatment for their patient. Brittany Harvey: Absolutely. It can be challenging to interpret that subgroup data across several different studies that are reporting on different regimens and different outcomes. And I appreciate you mentioning the driver mutation-positive guideline as well. Listeners can check out the companion episode with Dr. Puri for more information on what is changed in the driver mutation-positive guideline. Based on that primer, what is new for first-line therapy for patients with stage IV non-small cell lung cancer without driver alterations? Dr. Joshua Reuss: Even though I will say there is not a lot of new trial data that was incorporated into this guideline, there were some updates and just some meaningful long-term data that we incorporated. I think first and foremost, there is a new top-level recommendation in this guideline pertaining to molecular testing, which is absolutely critical in both the driver mutation-positive and driver mutation-negative space. I think we tend to think that, oh, well, molecular testing really only pertains to then finding a driver mutation. But the lack of a mutation is absolutely critical as well, right? Because that is what leads us down the mutation-negative pathway. We also need this molecular testing to assess PD-L1 status. We are seeing emerging data on molecular mutations that might confer resistance to certain immunotherapy-based strategies. So the committee felt strongly that a recommendation on molecular testing is critical to include in both the driver mutation-positive guideline and the driver mutation-negative guideline. I will also say that we are now seeing five and six-year updates from some of the landmark trials of immunotherapy in driver mutation-negative non-small cell lung cancer. It is really incredible to see that in some of these trials, we are seeing very impressive durability of the treatment in the patient subsets that we are commenting on. In others, perhaps that durability is less clear, and I think that leads to challenges in making a recommendation on any one particular regimen. And I think that is nowhere more clear than in the squamous subset. I think that was one perhaps subtle change that is in this guideline where, particularly in the PD-L1 negative squamous population, the committee felt that no one regimen really was worthy of standing above the others. Sometimes I think it is important to really champion one unique regimen if we feel that the data is there to support it. But I think it is equally important to list multiple regimens where the data is less clear. I think another point is that while perhaps there were no new regimens that we have added or that led to other clear changes in the prioritization of one regimen over another, there are other unique data subsets that I think come into play in making a decision and that really are important when looking at the discussion on any one recommendation from this guideline. For example, we know there is emerging data on perhaps the significance of molecular alterations in KEAP1 or STK11 and how that might influence frontline decision-making. You know, there is not a prospective phase III trial in this population, but I think we still need to use that data in certain scenarios to make recommendations for a particular patient. Another example of a trial that, again, did not change our recommendations, but I think one can incorporate in their decision making is the KEYNOTE-598 trial. Now, this is not a new study, but what it studied was pembrolizumab versus pembrolizumab plus ipilimumab in a PD-L1 high subset, and found that the addition of ipilimumab to pembrolizumab in the PD-L1 high population did not significantly improve clinical efficacy. And so while pembrolizumab plus ipilimumab is not an approved regimen, it is hard to extrapolate that to our combination treatments that are approved. I think some clinicians might find that data valuable when making a frontline treatment decision on a patient who has PD-L1 high status. So a bit of a whirlwind tour, but I think there are still multiple factors that went into this guideline that are important to review when making treatment decisions for any one patient. Brittany Harvey: Absolutely. I think what you just mentioned in having that upfront molecular testing is really key for individualized patient care. And the evidence summaries that you provide in addition to the recommendations are really important for clinicians to be able to refer to as they are making decisions in their clinic. So then beyond those changes for first-line therapy, what is updated for second-line and subsequent therapies? Dr. Joshua Reuss: For second-line and subsequent therapies, we did see one new treatment recommendation join these ranks, and that was telisotuzumab vedotin. Telisotuzumab vedotin, quite a mouthful. That is an antibody-drug conjugate. I like to think of that as smart chemotherapy, targeted chemotherapy, where you are trying to utilize some aspect of a marker that is selectively expressed or overexpressed on the cancer surface to then shepherd in the anticancer molecule, a highly potent chemotherapeutic in the case of currently approved antibody-drug conjugates, to exert antitumor killing effect. So in this case, the antibody-drug conjugate telisotuzumab vedotin targets MET overexpression. So telisotuzumab is an antibody targeting MET, and that is conjugated to an MMAE highly potent chemotherapeutic payload called vedotin. So we know MET can be selectively expressed and overexpressed in non-small cell lung cancer in both driver mutation-positive and mutation-negative subsets. The data that led to this approval was from the phase II LUMINOSITY trial which evaluated telisotuzumab vedotin, or Teliso-V, in many subsets. But the subset that really showed promise and was expanded was the EGFR wild-type, non-squamous, non-small cell lung cancer population with MET overexpression. And so in 78 patients with high levels of expression, the response rate here was 34.6%, median progression-free survival of 5.5 months, and a median overall survival of 14.6 months. With an overall acceptable safety profile; grade 3 or higher adverse events, neuropathy was perhaps the most common at 7%, also increased ALT at 3.5%, and pneumonitis at 2.9%. Now this was phase II data that led to an accelerated approval. There is an ongoing phase III study randomizing patients with high expression to Teliso-V versus docetaxel. That is the phase III TeliMET study. But it is nice that we now have another option for patients, perhaps a more biomarker-directed option with, again, this MET overexpression. And again, it further reinforces the importance of molecular testing in patients with traditionally driver mutation-negative non-small cell lung cancer, whether that is upfront or at progression, and in particular utilizing immunohistochemistry to assess MET expression in these patients. And this does join another ADC that we had previously made an update in our recommendation, which is trastuzumab deruxtecan, which is approved for those patients with HER2-overexpressing non-small cell lung cancer. So just again to reiterate the importance of molecular testing in patients both at the outset of their treatment and upon progression on frontline therapy. Brittany Harvey: Definitely. It is great to have this new antibody-drug conjugate join the treatment options, and as you mentioned, very important in this case to have that molecular testing done at the outset and at progression. So then in your view, what should clinicians know as they implement this living guideline, and how do these changes impact patients with non-small cell lung cancer? Dr. Joshua Reuss: Because there are so many different regimens that one can consider for any one patient, I think it is easy to become overwhelmed and stress on, "Am I making the right choice for my patient?" And I think one of the key take home points is that in many cases, there is no one right regimen. And I think one has to weigh several factors. It is the treatment schedule. It is the toxicity profile. It is the molecular profile of the patient. It is the patient preference. You know, there are so many factors here. And I would like to draw the reader and viewer's attention to an important section of these guidelines, particularly the Patient and Clinician Communication section, where we have a box focused on discussion points between patients and clinicians, which I think focuses on several of the high-level points that one can emphasize in making these decisions, ranging on things from: what are the goals of the treatment? What are the risks and benefits to any one approach? What are comorbidities that should be factored in? Common concerns, toxicity management, clinical trial consideration. All of these factors that I think are incredibly important in making that frontline treatment decision and implementing a regimen that both the clinician and, more importantly, the patient feels comfortable with. Brittany Harvey: It is really important that there is shared decision-making in these scenarios. And I think that patient-clinician communication section can tease out some of those preferences from the patient end and talk through the risks and benefits of different regimens as well. As we mentioned at the top of this episode, this guideline is a living guideline and updated on an ongoing basis. So what is the panel examining and keeping an eye on for future updates to this guideline? Dr. Joshua Reuss: So I think there are a lot of exciting new therapies and more up-to-date trials that we are anxiously awaiting the results of on our committee, and I think the oncology community in general is awaiting the results of. When we will have these results, I think, is a bit of an open-ended question, but I can give some insight on several of the trials that our committee is really keeping a close eye on. One that we have mentioned for several guideline iterations is the ECOG-ACRIN INSIGNA trial. This is a phase III clinical trial comparing pembrolizumab versus pembrolizumab plus carboplatin and pemetrexed chemotherapy in PD-L1 positive, non-squamous, non-small cell lung cancer. We talk about there being different regimens that can be considered in PD-L1 positive and PD-L1 high subsets, namely immunotherapy alone or immunotherapy plus chemotherapy, but there is no direct head-to-head comparison here. So this trial hopefully will answer that question. It has now finished accrual. There are other very interesting molecules and trials. I think another interesting compound is ivonescimab. This is a PD-1/VEGF bispecific antibody that is currently approved in China as monotherapy in patients with PD-L1 positive non-small cell lung cancer based off of the HARMONi-2 trial, where the progression-free survival of this bispecific antibody, ivonescimab, appeared superior to pembrolizumab. And we are looking closely at ongoing trials to see if these results will be replicated in an ex-China population. And if so, I think it could have a real impact and change on our guidelines. Still other very interesting things. There are obviously confirmatory studies for antibody-drug conjugates, such as the TeliMET study that I alluded to earlier, and many promising antibody-drug conjugates, both bispecific and trispecific antibody-drug conjugates, that hopefully can inform practice. And then there are several unique subsets of populations that I think we now are utilizing data on to make decisions, but a lot of that is retrospective in small subsets where we do not have that prospective data. And there are several trials ongoing in some of these subsets to try to gain clarity on what regimen may be the best for patients. One example is the phase III TRITON trial, which is looking at comparing CTLA-4 containing regimen, particularly the POSEIDON regimen of durvalumab plus tremelimumab and chemotherapy, versus the KEYNOTE-189 regimen, which is pembrolizumab plus carboplatin and pemetrexed, in patients with non-squamous, non-small cell lung cancer that have alterations in either KRAS, KEAP1, and/or STK11. There is a lot of both preclinical and clinical data to suggest that patients with these alterations in STK11 and KEAP1 may be more resistant to a PD-1 based treatment approach, and perhaps the incorporation of CTLA-4 can lead to a more meaningful response in this unique subset. Obviously, that data, it is retrospective, it is in small subsets. And when you add in a CTLA-4 molecule, you are also introducing greater risk for toxicity. So this trial is going to be very important in elucidating: is there a benefit in that unique subset? Does that data that we see retrospectively in this small subset hold true when evaluated in a prospective fashion? So while our guideline, our most recent comprehensive panel update, may not have had a lot of new data in it that has influenced frontline treatment decision-making, I think the future is bright and there are a lot of novel studies and novel treatments on the horizon that will hopefully improve the outcomes for our patients. Brittany Harvey: Absolutely. We will look forward to the results of those ongoing trials to provide more options and particularly clarity for patients with non-small cell lung cancer and to inform this guideline and its many updates to come. So I want to thank you so much for your work to rapidly and continuously update this guideline, and thank you for your time today, Dr. Reuss. Dr. Joshua Reuss: Thank you so much. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/thoracic-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines App available in the Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

In today's episode of Beating Cancer Daily, Saranne discusses the strategies to alleviate the misery and discomfort often accompanying a cancer diagnosis. Drawing from her experience in conquering Stage IV cancer, Saranne offers practical tips for tackling the challenges one step at a time, aiming to improve the overall quality of life for those going through the cancer journey. Stay tuned as Saranne shares insightful ways to navigate uncomfortable encounters and provides a humorous take on finding moments of joy amidst difficulties. Join us as we explore the small yet significant factors that can make a big difference in the fight against cancer.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Some people are told they're terminal, and then something inside them changes. Before the scans show progress, before symptoms shift, their bodies stop fighting and start responding. Today, you'll hear what survivors say changed first.In this deeply human episode of Renegade Remission, we explore a pattern that appears again and again in real survivor stories. Long before scans change or symptoms improve, many people describe an internal shift, caused by a reconnection to joy and purpose, or the support of loved ones who lift them up.Drawing from survivor memoirs, medically documented neurological recovery, and decades of research in psychoneuroimmunology, this episode reveals how emotional clarity, connection, and meaning can influence stress hormones, immune behavior, inflammation, and even gene expression.You'll hear two powerful stories. One from a Radical Remission survivor who stabilized after Stage IV cancer when she reclaimed joy and identity beyond illness. Another from a peer-reviewed neurological recovery where emotional safety and human connection supported unexpected brain repair.In this episode, you'll discover:Why healing often begins with a sense of safety rather than force or controlHow emotional shifts can lower cortisol, calm inflammation, and support immune accuracyThe role of purpose and meaning in regulating biology across serious illnessHow compassion and connection trigger measurable physiological changesWhy survivors so often trace recovery back to a moment when something inside softenedYou'll also learn why these shifts are not “just emotional,” and how science now confirms their biological impact across cancer, neurological disease, autoimmune illness, and chronic conditions.Listen now to understand why healing so often starts with safety, purpose, and connection, and how you can gently create the conditions for your own internal shift without pressure, performance, or perfection. This episode offers a grounded reminder that your body is listening, adapting, and still capable of change.Disclaimer This podcast is for educational purposes only and does not offer medical advice. Consult your licensed healthcare provider before making any changes to your treatment or health regimen. Reliance on any information provided is solely at your own risk.This podcast explores stories and science around ALS, dementia, MS, cancer, mind body recovery, healing, functional medicine, heart disease, regression, remission, integrative medicine, autoimmune conditions, chronic illness, terminal disease, terminal illness, holistic health, quality of life, alternative medicine, natural healing, lifestyle medicine, and remission from cancer, offering hope and insights for those seeking resilience and renewal.

Today on Beating Cancer Daily, Saranne passionately explores the therapeutic effects of laughing and crying, particularly in battling cancer. Her unique perspective emphasizes the importance of embracing tears—whether from joy or sadness—and how these emotional releases can contribute significantly to mental and physical well-being. Saranne shares touching anecdotes, practical advice, and intriguing research findings to highlight the healing power of tears and laughter, especially during challenging times like cancer diagnosis and treatment.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode, Saranne delves into the concept of life's speed bumps, particularly in relation to a cancer diagnosis. She shares her journey of discovering ways to decelerate and cherish life beyond the bounds of cancer treatments. Urging listeners to discover ways to integrate these 'speed bumps' into their daily lives, Saranne also invites listeners to share their unique strategies for adopting a slower pace, aiming to enhance the overall richness of life.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode, Saranne takes a chilly approach to wellness as she discusses the potential benefits of cold therapy and its effects on cancer treatment. With her signature optimism and wisdom gained from beating Stage IV cancer, Saranne invites listeners to consider the idea of integrating cold showers into their daily routine. Join her as she delves into the research, shares her personal experiences, and offers insights into how this unconventional practice can contribute to overall well-being. Get ready to explore new perspectives and find moments of joy as we continue to beat cancer daily together.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

 Today on Beating Cancer Daily, Saranne welcomes back functional medicine expert Jacqui Bryan for an in-depth conversation about alpha lipoic acid (ALA), a unique antioxidant that acts as a secret weapon against oxidative stress. Together, they break down what makes ALA so powerful for anyone looking to support their health, especially those impacted by cancer, diabetes, or premature aging. Saranne and Jacqui explore the differences between alpha-lipoic acid and alpha-linolenic acid, discuss how ALA is synthesized in the body, and highlight the importance of food-based sources such as broccoli, spinach, potatoes, and tomatoes. The episode also features crucial insights into when supplementation may or may not be appropriate, why food is usually the best source, and how community support can make the cancer journey more connected and hopeful. Jacqui Bryan is a certified nutrition specialist, whole health educator, health coach, and registered nurse. With decades of experience as a cancer survivor and in functional medicine, she empowers individuals to make informed, practical choices that improve quality of life. Jacqui is known for translating science into actionable wellness strategies for both cancer survivors and those seeking preventative health. "Free radicals get messed up and it makes them dysfunctional, prone to premature aging, kind of grumpy. And then you have these antioxidants and they're like your superheroes...they burst onto the scene with an electron and that neutralizes the free radical." ~Saranne Today on Beating Cancer Daily:·     Alpha lipoic acid (ALA) is a potent antioxidant naturally synthesized in the human body and also available from foods such as broccoli, spinach, potatoes, and tomatoes·     ALA supports nerve health and can help with neuropathy, especially in people with diabetes or as a side effect of cancer treatment·     ALA is both water and fat-soluble, giving it versatility to work in multiple cell environments·     Food sources are preferred over supplements due to bioavailability and lower risk of side effects·     Supplements should be used with caution, especially for those undergoing active chemotherapy, or with certain medical conditions like thyroid disorders or diabetes·     Ultra-processed foods contribute to inflammation and increased risk of diseases like cancer, emphasizing the need for a whole-foods-based diet·     ALA can regenerate other important antioxidants, such as vitamin C, vitamin E, and glutathione, offering even broader cellular protection·     Support, connection, and science-based guidance are critical tools for cancer survivors and caregivers in making daily empowered health choices Resources Mentioned:Beating Cancer Daily Episodes – "Antioxidant Episode", "Eye Health Episode", "Label Detective Episode" 2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_SuggestionsTo sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne   

Some people are told they're terminal… and their bodies heal anyway. Today, I want to show you how that actually happens.In this deeply human episode of Renegade Remission, we explore three true stories of people who healed or stabilized from illnesses considered terminal. These stories come from different worlds. One is a memoir-based Radical Remission account. One is a peer-reviewed medical case that surprised an entire oncology team. One is a documented neurological recovery in a condition long believed to be irreversible.Together, they offer something rare and grounding. Not false promises, but real examples of how adaptable and responsive the human body can be, even when the odds appear overwhelming.In this episode, you'll discover:A Radical Remission story from someone whose Stage IV cancer recovery defied every expectationA medically documented spontaneous remission that left doctors searching for explanationsA neurological recovery showing that even progressive conditions can shift under the right conditionsThe common biological and emotional themes that appear across these very different recoveriesWhy prognosis cannot account for immune reactivation, nervous system regulation, or human resilienceThese stories are not about guarantees. They are about possibility, biology, and what can happen when the internal environment begins to change.Listen now to ground yourself in real, documented stories of healing that go beyond statistics and timelines. Whether you are facing cancer, neurodegenerative disease, heart disease, or another serious diagnosis, this episode offers perspective, steadiness, and evidence that the body is often more capable than we are led to believe.DisclaimerThis podcast is for educational purposes only and does not offer medical advice. Consult your licensed healthcare provider before making any changes to your treatment or health regimen. Reliance on any information provided is solely at your own risk.This podcast explores stories and science around ALS, dementia, MS, cancer, mind-body recovery, healing, functional medicine, heart disease, regression, remission, integrative medicine, autoimmune conditions, chronic illness, terminal disease, terminal illness, holistic health, quality of life, alternative medicine, natural healing, lifestyle medicine, and remission from cancer, offering hope and insight for those seeking resilience and renewal.

In today's episode of Beating Cancer Daily, Saranne explores the ubiquitous nature of humor even during the most challenging times of a cancer journey. Having surpassed a Stage IV cancer diagnosis, Saranne emphasizes how embracing a comic perspective can offer a unique tool for coping and thriving. Listen in as she delves into the inspirational words of Dr. Seuss, "From there to here, from here to there, funny things are everywhere," encouraging listeners to cultivate their own "humor notebook." Through this exercise, you'll learn to spot the absurdities and quirks around you, turning potential pain points into moments of laughter. Join Saranne in this enlightening session and learn how to harness humor as we continue to beat cancer daily together.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In this episode, Saranne explores the power of comedy as a coping mechanism for individuals facing cancer. Joined by Missy Hall, a comedian going through cancer treatment, they discuss how humor has helped them navigate their journeys and maintain strong relationships. From incorporating their experiences into their comedy routines to finding humor in awkward moments, Saranne and Missy share their personal stories and highlight the healing potential of laughter. Join them as they delve into the importance of communication, support, and sharing one's story in real-time.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode of Beating Cancer Daily, Saranne delves into the intriguing topic of receiving signs from loved ones who have passed away. Drawing from her poignant experiences, including those with a patient named Rivka and her father and grandfather, Saranne explores the notion that those we've lost might still communicate with us in mysterious ways. From flickering lights to uncanny coincidences, she shares personal stories and research that suggest these signs are more common than one might think. Join Saranne as she navigates this fascinating subject, offering comfort and wonder to anyone coping with grief or seeking a deeper connection. Get ready to laugh, learn, and live your best days as we embark on this journey of beating cancer daily together.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

A deadly ICE shooting in Minneapolis sets off a sobering conversation about the direction of the nation. Ron speaks with Mark Becker, Wisconsin radio host at The Rational Revolution. Becker, also a childhood friend of Alex Pretti, providing some background on who Pretti was, from childhood til death, and speaks to his transformation from conservative to moderate Democrat. Next comes Ron's sobering conversation with Steven Cash, executive director of The Steady State, a group of former intelligence and defense officials warning about rising authoritarianism and weakened democratic guardrails.Later, immigration attorney and Texas House candidate Kate Lincoln-Goldfinch joins Ron to explain how ICE enforcement, sanctuary city debates, and administrative warrants are affecting public safety, immigrants, and local law enforcement across the country.Tune in to catch the Ron Show weekdays from 4-6pm Eastern time on Georgia NOW! Grab the app or listen online at heargeorgianow.com.#TheRonShow #HearGeorgiaNow #MarkBecker #StephenCash #TheSteadyState #KateLincolnGoldfinch #ImmigrationPolicy #Democracy #ICE #GeorgiaNOW

Today on Beating Cancer Daily, Saranne delves into the pervasive issue of overthinking, especially in the context of dealing with cancer. Sharing her own experience and perspective on spontaneity, humor, and play, she contrasts it with her husband's approach of meticulous overthinking. Saranne explores practical strategies to manage and overcome the mental loops that can distract from quality of life, including insightful advice from Scott Mots' CNBC article and techniques from Quora.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

In today's episode of Beating Cancer Daily, Saranne explores how managing cancer can be compared to handling a challenging job. Having conquered Stage IV cancer through three surgeries, 44 radiation treatments, and over two years of chemotherapy, Saranne shares insightful ways to improve the cancer journey using principles from Patrick's book on workplace dissatisfaction. Discover how addressing anonymity and irrelevance can transform your treatment experience. Join Saranne as she delves into meaningful, practical steps to not only survive but thrive during this journey, and continue living your best days as we beat cancer daily together.2025 People's Choice Podcast Awards Best Health Series FinalistRanked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025,and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 to 2025. Beating Cancer Daily is listened to in 140 countries across 7 continents and features over 400 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne  

Enhanced Show notes: Direct episode link for social: https://player.captivate.fm/episode/63fb5a68-0e43-4805-9746-8c094dd01266/Embed: Transcript link: https://share.descript.com/view/edc4w3EIlAlShayna Welsh Show NotesRelease date: Jan 21, 2026Title: Reclaiming Myself the Second Time Around with Shayna WelshEpisode: E211 (C261)Shayna Welsh represents the very young age group of breast cancer patients—those diagnosed in their early 20s. Shayna was first diagnosed at 23 with Stage II triple-positive breast cancer, and then again at 25 with Stage IV metastatic breast cancer. Shayna is a member of several breast cancer organizations, including the Young Breast Cancer Project, Living Beauty, Living Beyond Breast Cancer, and Under the Pencil. In this episode, Shayna reads her essay, “Reclaiming Myself the Second Time,” from the 2025 The Second Time Around issue of Wildfire Journal. Her piece explores the liminal space where identity is rebuilt—scar by scar, photo by photo, and moment by moment. April and Shayna discuss the impact of Shayna's cover photo on The Second Time Around issue of Wildfire, feeling things on your own timeline, whole-brain activities, and the complexities of living in the world with Stage IV metastatic breast cancer.More about this episode's sponsors: AnaOno: https://www.anaono.com/https://www.instagram.com/anaonointimates/Young Survival Coalition (YSC): https://youngsurvival.org/Learn more about Shayna: https://www.instagram.com/thrive_with_shayna/Purchase the The Second Time Around issue of Wildfire Journal: https://www.wildfirecommunity.org/shop/p/secondtimeBuy the Wildfire book Igniting the Fire Within: Stories of Healing, Hope & Humor, Inside Today's Young Breast Cancer Community: https://www.amazon.com/dp/B0BJVJ629F?ref_=pe_3052080_397514860Get the free Wildfire “Hot Flashes” email newsletter: https://www.wildfirecommunity.org/newsletter?rq=newsletterLearn about Wildfire writing workshops:...

Show notes and links: www.chrisbeatcancer.com/how-carl-mason-healed-stage-iv-lymphoma-after-treatment-failed