Podcasts about nonsteroidal anti

Dr. Jason Deck discusses article the #6 of 2023, “Nonsteroidal Anti-inflammatory and Corticosteroid Injections for Shoulder Impingement Syndrome: A Systematic Review and Meta-analysis,” which was originally published in Sports Health in July 2023. Dr. Jeremy Schroeder serves as the series host. Dr. Deck is a member of the AMSSM Top Articles Subcommittee, and this episode is part of an ongoing mini journal club series highlighting each of the Top Articles in Sports Medicine from 2023, as selected for the 2024 AMSSM Annual Meeting. Nonsteroidal Anti-inflammatory and Corticosteroid Injections for Shoulder Impingement Syndrome: A Systematic Review and Meta-analysis https://journals.sagepub.com/doi/10.1177/19417381221108726

JACI: In Practice Editor David Khan describes the November issue, the theme of which is Nonsteroidal Anti-inflammatory Drug-Exacerbated Respiratory Disease (NSAID-ERD). Theme topics covered include the burden, natural history, clinical characteristics, inflammatory heterogeneity, and biologic and non-biologic treatment of NSAID-ERD. Dr. Khan then presents the Highlights of the Original Articles in the issue, which are on the topics of Asthma, Dermatitis, Drug Allergy, Eosinophilic Disorders, Food Allergy, and Rhinitis and Sinusitis. 

Ghlichloo I, Gerriets V. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) [Updated 2021 May 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547742/ --- Send in a voice message: https://anchor.fm/las-poderosas-celulas-nk/message

Chapter 6 part 2. ReferencesJosh touts the PARADIGM-HF Trial Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure | NEJM which found this combination was superior to an ARB alone Joel mentions an early atrial natriuretic peptide trial by Julie Lewis et al. Atrial natriuretic factor in oliguric acute renal failure - American Journal of Kidney Diseases and here's a metanalysis that put this option to bed: Atrial Natriuretic Peptide for Management of Acute Kidney Injury: A Systematic Review and Meta-analysisSnack attack? Check out “Snack induced ANP” Snack-Induced Release of Atrial Natriuretic Factor | NEJMWant more natriuretic peptides than we discussed? Check out this review! Cardiac natriuretic peptides | Nature Reviews Cardiology or this fantastic review: Here's an excellent review of ANP effect on the kidney: ANP-induced signaling cascade and its implications in renal pathophysiologyCerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reportsJoel mentions the study which probed CRIC cohort regarding NSAIDs. Association of Opioids and Nonsteroidal Anti-inflammatory Drugs With Outcomes in CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study - American Journal of Kidney Diseases and you may like the discussion on NephJC: ​​No Pain for the Kidneys from NSAIDs — NephJCThe KDIGO guidelines can be found here CKD-Mineral and Bone Disorder (CKD-MBD) – KDIGO Regulation and Effects of FGF23 in Chronic Kidney DiseaseElegant work on the calcium sensing receptor by Martin Pollak https://doi.org/10.1016/0092-8674(93)90617-YeClaudin 14, PTH, and calcium absorption in the loop of Henle: Parathyroid hormone controls paracellular Ca 2+transport in the thick ascending limb by regulating the tight-junction protein Claudin14Carboxymaltose induced hypophosphatemia by increasing FGF-23. Randomized trial of intravenous iron-induced hypophosphatemiaCurrent "corrected" calcium concept challenged. | The BMJThe Dialysis Encephalopathy Syndrome — Possible Aluminum Intoxication | NEJMNephMadness covered Aluminum binders in 2016.Roger mentioned the use of ferric citrate as a phosphate binder Ferric Citrate Controls Phosphorus and Delivers Iron in Patients on Dialysis | American Society of NephrologyJoel reminded us of the misadventures in efforts to normalize hemoglobin, first in hemodialysis patients The Effects of Normal as Compared with Low Hematocrit Values in Patients with Cardiac Disease Who Are Receiving Hemodialysis and Epoetin | NEJMLater, in patients with CKD, normalization was also not shown to be better: Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease | NEJM , Normalization of Hemoglobin Level in Patients with Chronic Kidney Disease and Anemia | NEJMA quick shout out for roxadustat and the Nephmadness Anemia region! Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis | NEJM, #NephMadness 2021: Anemia Region – AJKD BlogIn this review of vasopressin, you can find an excellent discussion of basic stimuli and vasopressin receptors: Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems | Physiological ReviewsX-Linked Nephrogenic diabetes insipidus is very rare and there was theory that all patients originated from the same family and traveled to the US on the Hopewell ship JCI - X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis. This report describes another family from the Netherlands with nephrogenic DI including the finding that the urine osmolarity never exceeds 200 mOsm/kg. Hereditary Nephrogenic Diabetes Insipidus - GeneReviews® (and here's a family with central diabetes insipidus https://academic.oup.com/jcem/article/81/1/192/2649423?login=true )Although we have all learned that thiazides should be used with diabetes insipidus, to induce mild volume depletion, several case reports and animal data have found that acetazolamide might be the best diuretic for the job. Clinicians from Boston Medical Center tried it out in this report: ​​Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus | NEJM based on exciting data in mice! https://jasn.asnjournals.org/content/27/7/2082.shortADH appears to have an effect on potassium excretion. This was investigated by Giebesch who found, with clearance and micropuncture studies in rats plus isolated perfused tubules, ADH increased potassium secretion Influence of ADH on renal potassium handling: A micropuncture and microperfusion study A corollary should be that inhibition of ADH would increase the risk of hyperkalemia but this was not observed in the SALT-1 and SALT-2 trials. 5% of patients developed hyperkalemia in both the tolvaptan group and the placebo group Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia | NEJMV1 vasopressin as a pressor Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock: Two Case Reports and Literature ReviewWe wondered/debated on our observation that hyponatremia is not reliably seen in patients receiving vasopressin in the ICU. In the VASST trial, Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock, 1 patient in each study arm of nearly 400 patients developed hyponatremia. Note that patients with hyponatremia (

Join our panel of experts as they discuss the role of nonsteroidal anti-inflammatory (NSAID) lozenges in the treatment of sore throat. Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/964084?src=mkm_podcast_addon_964084

In this episode, we review the high-yield topic of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) from the MSK section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

On this episode of the PAIN POD, Mark Pain Guy Garofoli will take you on a journey of a pain guy in pain, and just what our patients hear from us as healthcare professionals, and what the healthcare system experience can be like when not being the one wearing the stethoscope, and rather being the patient in pain. Can anyone imagine being dropped off at the ER by your Wife and toddler on Friday the 13th during a pandemic to only begin a 3 month long excruciating journey of pain? Pain Guy Garofoli can tell you all about it, and provide a few clinical pearls to improve patient care along the way! This is not a campfire conversation, but you can feel free to download and listen while camping, swimming, biking, walking, or however, you'd like, just be forewarned that Mark will not be sparing any painful details. You're welcome and he's sorry, all at once! COVID & NSAIDs Info https://www.bbc.com/news/51929628 Jeong HE, et al. Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study. Clin Infect Dis. 2020 Jul 27. https://clinicaltrials.gov/ct2/show/record/NCT04334629 NSAID COX-1 & COX-2 Studies Feldman, M, et al. Do Cyclooxygenase-2 Inhibitors Provide Benefits Similar to Those of Traditional Nonsteroidal Anti-Inflammatory Drugs, with Less Gastrointestinal Toxicity. Ann Intern Med. 2000; 132: 134-143 Herndon, C. et al. Management of Chronic Nonmalignant Pain with Nonsteroidal Anti-inflammatory Drugs. Pharmacotherapy. 2008; 28 (6): 788-805. Masso Gonzalez EL, et al. Variability among nonsteroidal anti-inflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum 2010; 62: 1592-601. See omnystudio.com/listener for privacy information. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of the PAIN POD, Mark Pain Guy Garofoli will take you on a journey of a pain guy in pain, and just what our patients hear from us as healthcare professionals, and what the healthcare system experience can be like when not being the one wearing the stethoscope, and rather being the patient in pain. Can anyone imagine being dropped off at the ER by your Wife and toddler on Friday the 13th during a pandemic to only begin a 3 month long excruciating journey of pain? Pain Guy Garofoli can tell you all about it, and provide a few clinical pearls to improve patient care along the way! This is not a campfire conversation, but you can feel free to download and listen while camping, swimming, biking, walking, or however, you'd like, just be forewarned that Mark will not be sparing any painful details. You're welcome and he's sorry, all at once! COVID & NSAIDs Info https://www.bbc.com/news/51929628 Jeong HE, et al. Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study. Clin Infect Dis. 2020 Jul 27. https://clinicaltrials.gov/ct2/show/record/NCT04334629 NSAID COX-1 & COX-2 Studies Feldman, M, et al. Do Cyclooxygenase-2 Inhibitors Provide Benefits Similar to Those of Traditional Nonsteroidal Anti-Inflammatory Drugs, with Less Gastrointestinal Toxicity. Ann Intern Med. 2000; 132: 134-143 Herndon, C. et al. Management of Chronic Nonmalignant Pain with Nonsteroidal Anti-inflammatory Drugs. Pharmacotherapy. 2008; 28 (6): 788-805. Masso Gonzalez EL, et al. Variability among nonsteroidal anti-inflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum 2010; 62: 1592-601. See omnystudio.com/listener for privacy information. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode of the PAIN POD, Mark Pain Guy Garofoli will take you on a journey of a pain guy in pain, and just what our patients hear from us as healthcare professionals, and what the healthcare system experience can be like when not being the one wearing the stethoscope, and rather being the patient in pain. Can anyone imagine being dropped off at the ER by your Wife and toddler on Friday the 13th during a pandemic to only begin a 3 month long excruciating journey of pain? Pain Guy Garofoli can tell you all about it, and provide a few clinical pearls to improve patient care along the way! This is not a campfire conversation, but you can feel free to download and listen while camping, swimming, biking, walking, or however, you'd like, just be forewarned that Mark will not be sparing any painful details. You're welcome and he's sorry, all at once! COVID & NSAIDs Info https://www.bbc.com/news/51929628 Jeong HE, et al. Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study. Clin Infect Dis. 2020 Jul 27. https://clinicaltrials.gov/ct2/show/record/NCT04334629 NSAID COX-1 & COX-2 Studies Feldman, M, et al. Do Cyclooxygenase-2 Inhibitors Provide Benefits Similar to Those of Traditional Nonsteroidal Anti-Inflammatory Drugs, with Less Gastrointestinal Toxicity. Ann Intern Med. 2000; 132: 134-143 Herndon, C. et al. Management of Chronic Nonmalignant Pain with Nonsteroidal Anti-inflammatory Drugs. Pharmacotherapy. 2008; 28 (6): 788-805. Masso Gonzalez EL, et al. Variability among nonsteroidal anti-inflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum 2010; 62: 1592-601. See omnystudio.com/listener for privacy information.

In this episode Sal, Adam & Justin speak with good friend and author Max Lugavere about his newest book, The Genius Life. Health is important to everybody. (1:41) Is Max getting into ‘tiffs' over social media? (3:40) Making the case for organic vs non-organic. (6:24) Endocrine disruptors and their effect on our hormones. (9:45) The importance of seeking out the opposing view from your own. (14:08) Why is vegans' anger so misplaced? (17:50) The rising popularity of the carnivore diet. (21:30) Don't Fork Around! The value of dietary protein. (24:00) Do not be afraid of a good quality salt! (27:05) How ultra-processed foods highjack your hunger levels. (31:34) What you eat vs when you eat and its impact on your circadian rhythm. (32:29) Are your lights carcinogenic to your health? (37:15) The Vigger Trigger. The importance of thermal exercise. (43:06) Chronic use of anticholinergic drugs and the dangers to our body. (52:05) What's the problem with heating plastic containers in the microwave? (54:38) Fish consumption and mercury toxicity. (56:34) Taking caution when taking Nonsteroidal Anti-inflammatory Drugs (NSAIDs). (58:45) Knowledge is power. (1:02:17) The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary. (1:07:07)   Related Links/Products Mentioned February Promotion: MAPS Split ½ off! **Code “SPLIT50” at checkout** Pre-order ‘The Genius Life' by Max Lugavere Leader of Largest US Organic Food Fraud Gets 10-Year Term Mind Pump 990: Max Lugavere on the Dangers of Plastics, Building a Social Media Page, Coping with Loss & MORE BPA levels in humans may be much higher than previously thought Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life - Book by Max Lugavere and Paul Grewal Mind Pump 1227: The 5 Most Important Supplements to Take Sodium Intake and All-Cause Mortality over 20 Years in the Trials of Hypertension Prevention Redmond Real Salt ‘Ultraprocessed' foods may make you eat more, clinical trial suggests Lux Light Meter Free University of Eastern Finland: Frequent Sauna use Associated With Lower Cardiovascular Death Rate in men and Women Visit Infrared Sauna for an exclusive offer for Mind Pump listeners! Do Ibuprofen and NSAIDs Affect Athletic Performance? Visit NED for an exclusive offer for Mind Pump listeners! Mind Pump Free Resources Featured Guest/People Mentioned Max Lugavere (@maxlugavere)  Instagram Website Podcast Ellen Vora, MD (@ellenvoramd)  Instagram Layne Norton, PhD (@biolayne)  Instagram

Podcast Notes Key Takeaways If you’re going to eat a piece of produce’s skin or peel, buy organicProtein is the most satiating macronutrient; to facilitate weight loss, eat more proteinIf you’re eating a healthy, whole foods-heavy diet, aim to consume 3-5 grams of sodium per day (double what the American Heart Association recommends)Avoid seat salt—it’s packed with microplastics; Himalayan pink salt is bestTry to get 30 minutes of 1,000 lux intensity light before noon each day—this helps set the circadian rhythm(There are a variety of phone apps that allow you to measure an environment’s light intensity)Chronic use of anticholinergic drugs (i.e., antihistamines, Benadryl, and many sleep aids) is associated with a dramatically increased risk for dementiaOne of the best things you can do to limit exposure to endocrine-disrupting chemicals: stop storing/cooking food in plasticRead the full notes @ podcastnotes.orgIn this episode Sal, Adam & Justin speak with good friend and author Max Lugavere about his newest book, The Genius Life. Health is important to everybody. (1:41) Is Max getting into ‘tiffs’ over social media? (3:40) Making the case for organic vs non-organic. (6:24) Endocrine disruptors and their effect on our hormones. (9:45) The importance of seeking out the opposing view from your own. (14:08) Why is vegans' anger so misplaced? (17:50) The rising popularity of the carnivore diet. (21:30) Don’t Fork Around! The value of dietary protein. (24:00) Do not be afraid of a good quality salt! (27:05) How ultra-processed foods highjack your hunger levels. (31:34) What you eat vs when you eat and its impact on your circadian rhythm. (32:29) Are your lights carcinogenic to your health? (37:15) The Vigger Trigger. The importance of thermal exercise. (43:06) Chronic use of anticholinergic drugs and the dangers to our body. (52:05) What’s the problem with heating plastic containers in the microwave? (54:38) Fish consumption and mercury toxicity. (56:34) Taking caution when taking Nonsteroidal Anti-inflammatory Drugs (NSAIDs). (58:45) Knowledge is power. (1:02:17) The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary. (1:07:07)   Related Links/Products Mentioned February Promotion: MAPS Split ½ off! **Code “SPLIT50” at checkout** Pre-order ‘The Genius Life’ by Max Lugavere Leader of Largest US Organic Food Fraud Gets 10-Year Term Mind Pump 990: Max Lugavere on the Dangers of Plastics, Building a Social Media Page, Coping with Loss & MORE BPA levels in humans may be much higher than previously thought Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life - Book by Max Lugavere and Paul Grewal Mind Pump 1227: The 5 Most Important Supplements to Take Sodium Intake and All-Cause Mortality over 20 Years in the Trials of Hypertension Prevention Redmond Real Salt ‘Ultraprocessed’ foods may make you eat more, clinical trial suggests Lux Light Meter Free University of Eastern Finland: Frequent Sauna use Associated With Lower Cardiovascular Death Rate in men and Women Visit Infrared Sauna for an exclusive offer for Mind Pump listeners! Do Ibuprofen and NSAIDs Affect Athletic Performance? Visit NED for an exclusive offer for Mind Pump listeners! Mind Pump Free Resources Featured Guest/People Mentioned Max Lugavere (@maxlugavere)  Instagram Website Podcast Ellen Vora, MD (@ellenvoramd)  Instagram Layne Norton, PhD (@biolayne)  Instagram

Neck Manipulation Facts References: Makary MA, Daniel M; Medical Error: The Third Leading Cause of Death in the United States; British Medical Journal; May 3, 2016; Vol. 353; i2139. Lazarou J, Pomeranz BH, Corey PN; Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies; Journal of the American Medical Association; Vol. 279; No. 15; April 15, 1998; pp. 1200-1205. Giles GFL, Muller R; Chronic Spinal Pain: A Randomized Clinical Trial Comparing Medication, Acupuncture, and Spinal Manipulation; Spine; July 15, 2003; Vol. 28; No. 14; pp. 1490-1502. Wolfe MM, Lichtenstein DL, Singh G; Gastrointestinal Toxicity of Nonsteroidal Anti-inflammatory Drugs; The New England Journal of Medicine; June 17, 1999; Vol. 340; No. 24; pp. 1888-1899. Terrett AG; Misuse of the literature by medical authors in discussing spinal manipulative therapy injury; Journal of Manipulative and Physiological Therapeutics; May 1995; Vol. 18; No. 4; pp. 203-210. Weban A, Beck J, Raabe A, Dettmann E. Seifert V; Misuse of the terms chiropractic and chiropractor; J Neurol Neurosurg Psychiatry; May 2004; Vol. 75; No. 5; p. 794. Weban A; Inappropriate use of the title ‘chiropractor' and term ‘chiropractic manipulation' in the peer-reviewed biomedical literature; Chiropractic and Osteopathy; August 2006; Vol. 22; Vol. 14; p. 16. Church EW, Sieg EP, Zalatimo O, Hussain NS, Glantz M, Harbaugh RE; Systematic Review and Meta-analysis of Chiropractic Care and Cervical Artery Dissection: No Evidence for Causation; Cureus; February 16, 2016; Vol. 8; No. 2; e498. Cassidy, J David DC, PhD; Boyle, Eleanor PhD; Côté, Pierre DC, PhD; He, Yaohua MD, PhD; Hogg-Johnson, Sheilah PhD; Silver, Frank L. MD; Bondy, Susan J. PhD; Risk of Vertebrobasilar Stroke and Chiropractic Care: Results of a Population-Based Case-Control and Case-Crossover Study; Spine; Vol. 33(4S); February 15, 2008; pp. S176-S183. Kosloff TM, Elton D, Tao J, Wade M Bannister WM; Chiropractic Care and the Risk of Vertebrobasilar Stroke: Results of a Case–control Study in U.S. Commercial and Medicare Advantage Populations; Chiropractic & Manual Therapies 2015; Vol. 23; No. 19; pp. 1-10. Chaibi A, Russell MJ; A Risk–benefit Assessment Strategy to Exclude Cervical Artery Dissection in Spinal Manual Therapy: A Comprehensive Review; Annals of Medicine; March, 2019; Vol. 19; pp. 1-10. Moser N, Mior S, Noseworthy M, Cote P, Wells G, Behr M, Triano J; Effect of Cervical Manipulation on Vertebral Artery and Cerebral Haemodynamics in Patients with Chronic Neck Pain: A Crossover Randomised Controlled Trial; BMJ Open; May 28, 2019; Vol. 9; No. 5; pp. e025219. Kranenburg R, Tyer R, Schmitt M, Luijckx GJ, van der Schans C, Hutting N, Kerry R; Effects of Head and Neck Positions on Blood Flow in the Vertebral, Internal Carotid and Intracranial Arteries: A Systematic Review; Journal of Orthopaedic & Sports Physical Therapy; July 2019 [epub].

Drs Nuelle and Alaia discuss The Utility of Oral Nonsteroidal Anti-Inflammatory Drugs Compared With Standard Opioids Following Arthroscopic Meniscectomy: A Prospective Observational Study

Drs Nuelle and Alaia discuss The Utility of Oral Nonsteroidal Anti-Inflammatory Drugs Compared With Standard Opioids Following Arthroscopic Meniscectomy: A Prospective Observational Study

Where don’t we feel the impact of stress? It can affect the body, mind, our sleep, appetite, relationships, etc., creating a complicated (and sometimes painful) web of causes and effects. By the time we’re forced to address pain, it can be tough to identify what the underlying trigger was. Join Dr. Liou, in this lighthearted conversation with Jen about workplace stress and pain, while they take a winding path through the topics of stretching, pain medicine, biorhythms, and depression. Jen discusses her transitioning career from teacher to principal to real estate broker and the unexpected physical changes that came with each new role.  Jen shares how revelatory it was to have someone else ask the right questions about her pain, which led to constructive and practical changes in her daily routine. Who do you talk to for help uncovering and addressing the roots of your stress and pain? Key Points from this Episode: Mechanical and environmental stressors in the workplace. The value of conversation in treatment to connect the dots and set a productive course of recovery. Safe and productive stretching through muscle activation. Understanding the role of over-the-counter Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for pain relief. The unexpected and unpredictable benefits that can arise after removing stress. Schedules that adapt to your natural biorhythms. Biorhythms and depression: the importance of finding successful motivators to avoid the cycle of depression and fatigue when the system is neuro-biochemically compromised. Appropriate responses to pain or stress are as unique as the individual feeling them. Links : Jen Jarta Real Estate - https://jjarta.kw.com/ NSAIDS and healing - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764618/ NSAIDS and GI health - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890944/ NSAIDS and cardiovascular health  - https://www.medscape.com/viewarticle/879811#vp_1 On Stretching - http://stopeverydaypain.com/2014/06/22/stretching-pain-feels-good-good/   Music From This Episode Eric and Magill — https://ericandmagill.bandcamp.com/ Samuel Vas-Y -  https://samyel.bandcamp.com/   Follow Us: Everyday Pain Forum – https://www.facebook.com/everydaypainguide/ Everyday Pain – http://stopeverydaypain.com/ Everyday Pain Twitter – https://twitter.com/noeverydaypain  

Five articles from the December 2017 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles for this month are "In Vitro Chondrotoxicity of Nonsteroidal Anti-inflammatory Drugs and Opioid Medications", "The Incidence of Subsequent Meniscal Surgery Is Higher in the Anterior Cruciate Ligament-Reconstructed Knee Than in the Contralateral Knee", "A Comparison of 2-Year Outcomes in Patients Undergoing Tibiofemoral or Patellofemoral Matrix-Induced Autologous Chondrocyte Implantation", "Epidemiology of Posterior Glenohumeral Instability in a Young Athletic Population", and "Rotator Cuff Calcific Tendinitis: Ultrasound-Guided Needling and Lavage Versus Subacromial Corticosteroids: Five-Year Outcomes of a Randomized Controlled Trial".   Click here to read the articles.

Generic Name ketorolac Trade Name Toradol Indication pain Action pain relief due to prostaglandin inhibition by blocking of the enzyme cyclooxygenase (COX) Therapeutic Class nonsteroidal anti-inflammatory agents, nonopioid analgesics Pharmacologic Class pyrroziline carboxylic acid Nursing Considerations may cause GI bleeding,… The post Ketorolac: Toradol (nonsteroidal anti-inflammatory agents, nonopioid analgesics) appeared first on NURSING.com.

Generic Name indomethacin Trade Name Indocin Indication Inflammatory disorders when patients do not respond to other medications Action Decreases pain and inflammation by inhibiting prostaglandin synthesis Therapeutic Class antirheumatics, ductus arteriosus patency adjuncts (IV only), nonsteroidal anti-inflammatory agents Pharmacologic Class… The post Indomethacin: Indocin (antirheumatics, ductus arteriosus patency adjuncts (IV only), nonsteroidal anti-inflammatory agents) appeared first on NURSING.com.

Generic Name ibuprofen Trade Name Advil / Motrin Indication Mild to moderate pain, inflammatory states Action Decreases pain and inflammation by inhibiting prostaglandins Therapeutic Class antipyretics, antirheumatics, nonopioid analgesics, nonsteroidal anti-inflammatory agents Pharmacologic Class nonopioid analgesics Nursing Considerations may cause… The post Ibuprofen: Advil / Motrin (antipyretics, antirheumatics, nonopioid analgesics, nonsteroidal anti-inflammatory agents) appeared first on NURSING.com.

Interview with Timo W. Hakkarainen, MD, MS, author of Nonsteroidal Anti-inflammatory Drugs and the Risk for Anastomotic Failure: A Report From Washington State’s Surgical Care and Outcomes Assessment Program (SCOAP)

Nonsteroidal Anti-inflammatory Drugs are a class of medicine used to reduce fever and treat acute or chronic conditions where pain and inflammation are present.  They are used, generally for the relief of rheumatoid arthritis, osteoarthritis, inflammatory arthropathies, gout, menstrual pain, headaches, post operative pain, and fever. Side effects include: myocardial infarction, stroke, erectile dysfunction, nausea, vomiting, dyspepsia, gastric ulceration, diarrhea, acute renal failure, tubular necrosis, broncospasm, rash, IBS symptoms, and even photosensitivity. BUT…NSAID’s are effective for the relief of pain…as runners we know this. As runners many or most of us rely on ibuprofen or naproxen sodium to recover from injuries.  So what does science tell us about the efficacy of Nonsteroidal Anti-inflammatory Drugs?    How are we to deal with the problem with NSAID’s? Links: http://fellrnr.com http://fellrnr.com/wiki/NSAIDs_and_Running http://www.monteladner.com The song “The Day” was by Moby  http://www.moby.com/ Presenting Mr. Robin Bearse: http://neilbearse.com ONLY IF YOU LIKE IT: Phedippidations is supported every month through the very kind and sincerely generous financial support of 42 fellow runners:  William, Vera, Katie, Heather, Ryan, Chaise, Andie, Gordon,  Scott, Mike, David, Jeff, Colin, Jason, Diane, Al, Cheryl, Ron, Mark, Martha, Greg, Jim, Maddy, Tim, Bill, Kevin, Michael, David, Doug, Vance, Brad, Rob, Marcelo, Andrew, Shawn, Roberto, Zaki, Ria, Jan, Margaret, James and one Anonymous fellow runner! THANK YOU! {http://support.steverunner.com} Follow me on:  Blog: http://steverunnerblog.com Twitter: http://twitter.steverunner.com Facebook: http://facebook.steverunner.com Plus: http://plus.steverunner.com Stream: http://stitcher.steverunner.com Apple App: http://iapp.steverunner.com Android App: http://android.steverunner.com Support: http://support.steverunner.com

A study in the May issue of Gastroenterology examines the influence of aspirin and NSAID use on risk of diverticulitis and diverticular bleeding in a large prospective cohort. Dr. Kuemmerle speaks w/ author Dr. Lisa Strate of the University of Washington

Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD). Several mechanisms have been proposed to explain these findings including increased shedding of the soluble ectodomain of the amyloid precursor protein (sAPP), which functions as a neurotrophic and neuroprotective factor in vitro and in vivo. Objective: To clarify whether NSAIDs consistently stimulate sAPP secretion. Methods: 293-EBNA cells with stable overexpression of an APP-alkaline phosphatase fusion protein (APP-AP), SH-SY5Y and PC12 cells or primary telencephalic chicken neurons were treated with ibuprofen or indomethacin. APP shedding was then determined by measuring AP activity in conditioned media, Western blot analysis with antibodies against total sAPP or specific for sAPP-alpha, or in a pulse-chase paradigm. Results: AP activity in conditioned media was not increased after NSAID treatment of 293-EBNA cells whereas it was elevated by phorbol ester. Surprisingly, ibuprofen or indomethacin treatment of SH-SY5Y and PC12 cells expressing endogenous APP did not cause changes in sAPP or sAPP-alpha secretion or downregulation of cellular APP. These findings were further corroborated in primary chicken neuronal cultures. Conclusions: Using various experimental settings, we were unable to confirm sAPP or sAPP-alpha stimulation with the NSAIDs ibuprofen and indomethacin in transfected and nontransfected cells of neuronal and nonneuronal origin. Importantly, these findings seem to rule out chronic sAPP stimulation as an alternative mechanism of NSAID action in AD. Copyright (C) 2008 S. Karger AG, Basel

Whether misoprostol, a synthetic prostaglandin E1 analogue, should be routinely prescribed along with nonsteriodal anti-inflammatory drugs (NSAIDS) to prevent gastric damage is of great clinical importance and has profound cost implications. No consensus exists on whether misoprostol cotherapy results in a cost-saving, is cost-effective, or is costly. The different conclusions reached by five economic evaluations of misoprostol can be explained solely by the assumed absolute risk reduction of symptomatic ulcer, which was more than seven times greater in the studies that concluded that misoprostol was cost-effective than in a study that concluded misoprostol to be costly. Since no study has directly shown the effectiveness of misoprostol cotherapy in preventing clinically significant ulcer disease (ie, hemorrhage and preforation), it is impossible to judge which assumptions are most appropriate. The absence of firm data on the rate of NSAID-induced gastric ulcers reduced by misoprostol makes it impossible to conclude whether it is cost-effective in patients with chronic arthritis who use NSAIDS.