Podcasts about all cause mortality

Skinny Fat (aka Normal Weight Obesity) isn't just about looking soft in the mirror, it's about your health. Having Normal Weight Obesity increases your risk of getting Type II Diabetes, Heart Disease, and All-Cause Mortality. Do you know how to avoid and reverse it?Find out in today's episode!Things referenced:10 Reasons You Don't Look Like You Work Out: https://www.digitalbarbell.com/looklikeyouliftCalorie and Protein Calculator: https://www.digitalbarbell.com/calorieandmacronutrientcalculatorOur Program Pricing And Options: https://www.digitalbarbell.com/options

In this 'Inbetweenie' episode of the Movement Logic podcast, Sarah delves into the widespread misinterpretation of a 2014 research study titled 'Ability to Sit and Rise from the Floor as a Predictor of All-Cause Mortality.' Popularly known as the Sitting Rising Test (SRT), the study has been sensationalized in the media and on social platforms, claiming that the ability (or inability) to get up from the floor without assistance can predict mortality. Sarah critiques the study's methodology, the pitfalls of its media representation, and the critical difference between correlation and causation. She also emphasizes the importance of proper interpretation to avoid fear-mongering and encourages training in strength and balance for overall health benefits.Get on our Wait List for the Bone Density Course!Follow us on Instagram @movementlogictutorials01:08 Overview of the Misinterpreted Study03:35 Details of the Sitting Rising Test (SRT)04:21 Methodology and Findings of the Study14:33 Critique of the Study's Methodology23:43 Misinterpretations and Media Hype29:17 Conclusion and Final ThoughtsReferences: Episode 15: 3! Easy! Rules! About! Research!Ability to sit and rise from the floor as a predictor of all-cause mortality(abstract)Conor O'Shea podcast: Taking Control of Your Pain Through MovementSRT Test on YouTubeDiscover Magazine: Simple Sitting Test Predicts How Long You'll Live

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: 5 crazy things that destroy your health. (2:17) How much does your mental state affect your physical state? (28:42) Polarizing personalities and knowing your teammates. (32:17) Why with some studies you must be careful how you interpret the data. (43:51) The difference between sleeping with and without Eight Sleep. (46:16) The staggering shift in culture. (49:40) Reducing the ‘puffy eye' look. (55:59) #ListenerLive question #1 – What can I do to balance my lower back out? (58:07) #ListenerLive question #2 – The total volume (weight x reps) decreases until I can get up to (or close to) the original rep range. Will this still produce gains, and is this the right way to achieve progressive overload? (1:05:31) #ListenerLive question #3 – Are there other obvious and effective ways I can lean into my extra range of motion on traditional exercises to unlock additional gains? (1:19:21) #ListenerLive question #4 – Workout-wise, after all these new developments and recommendations, should I get my CPT so I can train myself or should I get a personal trainer who's willing to educate me? (1:33:06) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit Eight Sleep for an exclusive offer for Mind Pump Listeners! ** Code MINDPUMP to get $350 off Pod 4 Ultra. Currently, it ships to the United States, Canada, the United Kingdom, Europe, and Australia. ** Visit Caldera Lab for an exclusive offer for Mind Pump listeners! **Code MINDPUMP20 for 20% off your first order of their best products. ** March Promotion: MAPS Performance or MAPS Performance Advanced 50% off! ** Code MARCH50 at checkout ** Sitting risks: How harmful is too much sitting? - Mayo Clinic How Much Exercise You Need to Offset Sitting All Day HANDGRIP DYNAMOMETER Muscle Strength, Physical Fitness, Balance, and Walking Ability at Risk of Fall for Prefrail Older People Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Media overload is hurting our mental health. Here are ways to manage headline stress News addiction linked to not only poor mental wellbeing but physical health too, new study shows Association between eating rate and obesity: a systematic review and meta-analysis Psychological prehabilitation improves surgical recovery Space Agency Offers $5,000 to Volunteers Willing to Stay in Bed for 10 Days How and Where people spend their time 1930-2024 - YouTube Visit NED for an exclusive offer for Mind Pump listeners! ** Code MINDPUMP at checkout for 20% off ** Stick Mobility | Snake Reach | 1 Long Add Windmills to Your Workout to Increase Your Deadlift Strength – Mind Pump TV Kettlebell Kings Presents: Kettlebell Suitcase Carries – Kettlebells 4 Aesthetics KINSTRETCH – Functional Anatomy Seminars Justin's Road to 315 Push Press Mind Pump #2255: The Smart Way to Improve Speed, Power, & Performance With Brian Kula How To Do The Pelvic Clock Exercise – Mind Pump TV Diaphragmatic Breathing Exercises & Techniques Mind Pump #1822: Wim Hof on How to Control Your Immune System With Breathwork Emotional Release of the Psoas - Montgomery Somatics Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Brian Kula (@kulasportsperformance) Instagram Wim Hof (@iceman_hof) Instagram  

Der er ingen tvivl om at det er usundt at være tyk, eller er der? Vi får tudet ørene fulde af at det er usundt at være tyk, at det er forkert at være tyk og at alle ens problemer løser sig hvis bare man taber sig, men hvorfor det er faktuelt forkert forklarer Rasmus Køster-Rasmussen i denne episode. Rasmus der er podcastvært på podcasten Radio Ligevægt, og læge og forsker med speciale i vægtudvikling, har selv skulle se det vægtparadigme vi har i vores samfund dybt i øjnene for at forstå, hvor mange fejlslutninger der florerer omkring det at være tyk og det at være usund. I denne episode centrerer vi os om spørgsmålet: Er det usundt at være tyk, og her forklarer Rasmus blandt andet, at hvis vi skal vurdere om et vægttab er sundhedsgavnligt eller sundhedsskadeligt, bliver vi nødt til at vægte skadevirkninger overfor gavnlige effekter, men hvad, kan der være skadevirkninger forbundet med vægttab tænker du måske. Hør svaret i episoden.Det kommer vi blandt andet ind på i episoden: Censur i forskningen omkring BMI og dødOm der er forskel på tilsigtede og utilsigtede vægttab i relation til øget dødelighedOm vægttab er vejen til mere sundhedHvordan det som sundhedsprofessionel kan være udfordrende at formidle paradigmeskiftVægttabsparadigmetOm vi tager modet fra folk når vi fortæller dem at det ikke er usundt at være tykHvordan alle slankekure virker på kort sigt og ikke på lang sigtHvordan både en slankekur og en livsstilsintervention er synonymer for energirestriktionerOm det er muligt at lave indsatser der kan hjælpe mennesker med at holde vægten nedeHvad der gør at nogle mennesker kan holde et vægttabOm vægttab har en effekt på risikoen for blodpropperHvordan man øger sundheden hvis det ikke skal handle om vægttabHvilke fysiske og psykiske skadevirkninger der kan være forbundet med vægttabOm en høj BMI er forbundet med øget dødelighed og kardiovaskulær sygdomOm risikoen for tidlig død forbundet med en høj vægt reguleres, når vi justerer for andre faktorer så som ulighed i sundhed og vægtstigmatiseringHvordan du kan lære at slutte fred med din krop som den erI episoden deler jeg at du kan teste hvor intuitivt dit spisemønster er via min test: Spiser du intuitivt. Testen kan du hente via linket her.Et randomiseret kontrolleret forsøg viste at en intensiv livsstilsintervention med fokus på vægttab ikke reducerede antallet af kardiovaskulære sygdomme hos overvægtige voksne med type 2-diabetes (1)Intensive livsstilsinterventioner ændrer umiddelbart ikke på risikoen for dødelighed blandt mennesker med prædiabetes eller type 2-diabetes (2)Et stort systematisk review der samlede forskellige vægttabsprogrammer viser et gennemsnitligt vægttab på 1,8 kilo (3)Vægtdiskrimmination er forbundet med en næsten 60% øget risiko for dødelighed (4)Hvis et vægttab skal bevares skal energirestriktionen vedholdes, i en sådan grad at det i mange tilfælde vil kunne sammenlignes med anorektisk adfærd, og små vægtudsving skal monitoreres hurtigt  (5,6)Energirestriktion er relateret til afminiralisering af knoglerne (7)Kilder:1: Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013 2: Zucatti et al. Long-term Effect of Lifestyle Interventions on the Cardiovascular and All-Cause Mortality of Subjects With Prediabetes and Type 2 Diabetes: A Systematic Review and Meta-analysis. Diabetes Care. 20223: Madigan et al. Effectiveness of weight management interventions for adults delivered in primary care: systematic review and meta-analysis of randomised controlled trials. BMJ. 2022 4: Sutin AR, Stephan Y, Terracciano A. Weight Discrimination and Risk of Mortality. Psychol Sci. 2015 5: Wing RR, Phelan S. Long-term weight loss maintenance. Am J Clin Nutr 20056: Weightloss maintenance for 10 years in the National Weight Control Registry. Am J Prev Med. 20147: Johnson and the Look AHEAD Study Group. The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes

Today we talk about working out smarter, not harder. We also dive into the marketing gimmick that is 10,000 steps a day, and talk about what the evidence based literature says when it comes to how much you're moving. Lastly, we unpack how to deal with life when things don't go as planned. Life is hard, but good friends and a solid community lightens the load. We're here for you, friends!Timestamps:[1:48] Welcome[4:00] Discussion on Red Dye 3[14:20] Can you explain what to do when you're really sore and can't workout for days? How to deal with muscle soreness after strength training?[32:20] What's the research on steps per day targets?[50:21] How to cope with your life not going according to planEpisode Links:UVA Today Article: FDA Bans Dye No. 3 in Foods, Decades After Banning It in CosmeticsFDA Article: FDA to Revoke Authorization for the Use of Red No. 3 in Food and Ingested DrugsCSPINET Article: Red 3: Why hasn't the FDA banned this carcinogenic food dye?PubMed: Association of Step Volume and Intensity with All-Cause Mortality in Older WomenThe Lancet: Daily steps and all-cause mortality Sponsors:Go to http://mdlogichealth.com/mc  and use coupon code WELLFED for 10% off.Go to drinklmnt.com/wellfed and use code WELLFED to get a free 8-pack with any drink mix purchase!Go to blissy.com/wellfed and use code WELLFED for 30% off your purchase!Go to wellminerals.us/adrenal-stress-less/ and use code WELLFED to get 10% off your order.

Step Count Increasing Recovery: https://pubmed.ncbi.nlm.nih.gov/38390... Cardiovascular Endurance and Injury Risk In Athletes: https://journals.lww.com/nsca-jscr/fu... Step Count and All Cause Mortality - https://pubmed.ncbi.nlm.nih.gov/37676... Apply For Coaching - https://bit.ly/3Qpfdux My Instagram - https://bit.ly/3Uy2zfb MacroFactor Diet Tracking App (Use code PEELER for a 2-Week FREE Trial!) - https://bit.ly/49Vz2AD Leviathan Nutrition (Code: ADAM10) - https://leviathan-nutrition.com/ Built Bar (code PEELER for 10% off) - https://builtbar.com/

In this game-changing episode, I'm tackling one of the most confusing topics for women over 40—what type of exercise actually works for maintaining a healthy weight, strong bones, and vibrant energy as we age? Drawing from both my personal journey and decades of research, I'm exposing the outdated myths about cardio and weight training that might be holding you back from your best health. You'll discover why the conventional wisdom about endless treadmill sessions could be sabotaging your results and learn about the surprising connection between grip strength and longevity. If you're frustrated with your current fitness routine or worried about maintaining your independence as you age, this episode is your roadmap to building a stronger, more resilient body that keeps up with your vibrant life. What you'll learn: The shocking truth about muscle loss after 40 and what it means for your metabolism Why your grip strength could be the most important health metric you're not measuring The game-changing research about VO2 max and longevity How to combine cardio and weights for optimal results at any age Simple strategies to prevent bone loss and maintain independence The most effective exercise sequence to transform your fitness routine Why the old "cardio-first" approach might be working against you   Full show notes: https://www.jjvirgin.com/cardiovsweights Hand Grip Dynamometer: https://amzn.to/48OI2a1 Download my free Resistance Training Cheat Sheet: https://jjvirgin.com/resistance TRX Resistance Training Equipment: Free Shipping on all orders $99+: https://trxtraining.sjv.io/EKrvrP Weighted Vest: https://amzn.to/4aSOVIM Study: Influence of early hip fracture surgery in the elderly on mortality, readmissions, dependence and quality of life: https://consensus.app/papers/influence-fracture-surgery-mortality-readmissions-ruizromero/de4487d539d4519aa7541b29febae142/?utm_source=chatgpt Study: Long-term Change in Cardiorespiratory Fitness and All-Cause Mortality: https://www.mayoclinicproceedings.org/article/S0025-6196(16)30257-9/abstract Study: Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies: https://pubmed.ncbi.nlm.nih.gov/28549705/   Episode Sponsors:  Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products Go to qualialife.com/VIRGINWELLNESS to try Qualia risk-free for up to 100 days and code VIRGINWELLNESS for an additional 15% off

Mind Pump Fit Tip: Stop doing “3 Sets of 12” to build muscle & DO this instead! (2:08) Cringy politicians. (19:38) We need each other. (24:25) The difference between a prebiotic and a probiotic. (38:27) Food dyes and your children's health. (39:43) Brilliant marketing by Plunge. (49:16) Strength gains in the elderly. (55:21) Shout out to Jake Heyen! (57:54) #ListenerLive question #1 – If I eat more fat can that cause me to gain more weight during a cut? (59:32) #ListenerLive question #2 – How should you workout while pregnant? (1:15:12) #ListenerLive question #3 – Am I losing out on a serious amount of gains due to my body not processing everything correctly? And how can I resolve this? (1:25:45) #ListenerLive question #4 – Do you see lift changes between programs? (1:34:41) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit Organifi for the exclusive offer for Mind Pump listeners! ** Promo code MINDPUMP at checkout for 20% off. ** Visit Plunge for an exclusive offer for Mind Pump Listeners! ** Code MINDPUMP at checkout for $150 off your order ** October Promotion: MAPS Muscle Mommy 50% off! ** Code OCTOBER50 at checkout ** Mind Pump #1827: The 3 Best Rep Ranges to Build Muscle & Burn Fat Mind Pump #1932: Lifting Heavy Vs. Lifting Light What's Driving Women To The Left And Men To The Right? - Arthur Brooks California is first state to banish Froot Loops from school cafeterias Landmark Ruling Declares Fluoridated Water a Threat to Children's IQ California Autism Prevalence by County and Race/Ethnicity: Declining Trends Among Wealthy Whites Liquid Death Is Selling a Limited Edition Cold Plunge That Will Have You 'Flirting With Hypothermia' Can You Gain Muscle as You Age? New Research Says Yes! Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Mind Pump Newsletter Get your free Sample Pack with any “drink mix” purchase! Also try the new LMNT Sparkling — a bold, 16-ounce can of sparkling electrolyte water: Visit DrinkLMNT.com/MindPump Building Muscle with Adam Schafer – Mind Pump TV Mind Pump # 1375: How to Train Before, During & After Pregnancy Mind Pump # 548: Ben Pakulski is Giving Away 100 Pounds of Pure Muscle MAPS Prime Pro Webinar Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Ronnie Coleman (@ronniecoleman8) Instagram Dexter “The Blade” Jackson (@mrolympia08) Instagram Bret Weinstein (@bretweinstein)  Twitter Arthur Brooks (@arthurcbrooks)  Instagram Max Lugavere (@maxlugavere) Instagram Mark Bell (@marksmellybell) Instagram Chris Williamson (@chriswillx) Instagram Jake Heyen (@jakeheyen) Instagram Ben Pakulski (@bpakfitness) Instagram

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page.  Mind Pump Fit Tip: Build muscle now, lose it, build muscle again much faster the second time around. (2:08) The motivation behind Adam's transformation Docuseries: “I Lost 50 lbs. of Muscle; Watch Me Build it Back.” (11:27) Couple workouts. (25:34) Going off to college and the possibility of leaving California. (30:06) Mind Pump Recommends ‘Masters of the Air' on Apple+. (34:05) “Hard times create strong men. Strong men create good times. Good times create weak men. And weak men create hard times.” (38:53) The Resistance Training Revolution. (43:46) Gummies are the trend. (47:29) The best bar soap lather out there! (48:17) The three-bolt rule. (50:46) Shout out to Masters of Air! (58:27) #Quah question #1 – I'm using a GLP-1 and doing the MAPS GLP-1 program, but I feel like it's not enough. I've done Anabolic and Aesthetic before and love those. I already walk as well but feel like I need more strength training exercises. What should I do? (59:22) #Quah question #2 – You speak about the 3-2-1 sleep protocol (describe the protocol), but what do you do or suggest people do in the last hour without screens? And for people who have made watching TV to fall asleep their routine, what suggestions do you have to fill this space until you're ready to fall asleep? (1:04:16) #Quah question #3 – If I don't have access to places that have water tanks and DEXA scans, what is the next best-recommended way to test my body fat? (1:10:01) #Quah question #4 – I just opened a training studio. Do you have any advice? (1:13:43) Related Links/Products Mentioned Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off** Visit Caldera Lab for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off your first order of their best products ** September Promotion: MAPS Starter | Starter Bundle 50% off! ** Code SEPTEMBER50 at checkout ** Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy Mind Pump #1322: What's Your Real Muscle Building Potential? (And how to get there…) Mind Pump TV - YouTube Watch Masters of the Air - Show - Apple TV+ Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Mind Pump #2187: Why Building Muscle Is More Important Than Losing Fat With Dr. Gabrielle Lyon Visit MASSZYMES by biOptimizers for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP10 at checkout** Mind Pump #2410: How to Maximize Fat Loss & Preserve Muscle on GLP-1s (Introducing MAPS GLP-1) Use the 3-2-1 Formula for Best Sleep Results | Cabral Concept 2526 Mind Pump Fitness Coaching Course Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Mind Pump Fitness Coaching (@mindpumptrainers) Instagram  

In this episode, we review the pharmacology, pharmacokinetics, adverse effects, monitoring, medicinal chemistry, and more of loop diuretics. Key Concepts Loop diuretics (furosemide, torsemide, bumetanide, ethacrynic acid) are the most potent type of diuretic and are used to relieve edema. Loop diuretics cause an increased loss of sodium, chloride, potassium, hydrogen, magnesium, and calcium ions into the urine. Excessive loss of these ions manifests as hypokalemia, hypomagnesemia, and metabolic alkalosis. Loop diuretics have an S-shaped dose response curve – a minimum dose is required for diuresis and a “ceiling” effect occurs at higher doses (leading to more ADRs). Doses should be individualized based on the clinical response of the patient. Ethacrynic acid is incorrectly used in patients with a “sulfa” allergy. The other loop diuretics contain a sulfa moiety but are safe for use in patients with “sulfa” allergy (e.g. allergy to sulfamethoxazole-trimethoprim). The TRANSFORM-HF trial strongly suggests that there is no clinical difference between furosemide and torsemide. References Rachoin JS, Cerceo EA. Four nephrology myths debunked. J Hosp Med. 2011;6(5):E1-E5. doi:10.1002/jhm.703 Strom BL, Schinnar R, Apter AJ, et al. Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N Engl J Med. 2003;349(17):1628-1635. doi:10.1056/NEJMoa022963 Buggey J, Mentz RJ, Pitt B, et al. A reappraisal of loop diuretic choice in heart failure patients. Am Heart J. 2015;169(3):323-333. doi:10.1016/j.ahj.2014.12.009 Mentz RJ, Anstrom KJ, Eisenstein EL, et al. Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial. JAMA. 2023;329(3):214-223. doi:10.1001/jama.2022.23924

Join Dr. Clancy and Dr. Donaldson as they discuss heat-related illnesses-prevention, early interventions out in the field, and diagnostic and emergency resuscitation measures.   CME Credit Available:  https://uiowa.cloud-cme.com/course/courseoverview?P=0&EID=66600  References/Resources:  Association of Extreme Heat with All-Cause Mortality in the Contiguous US, 2008-2017. Jama Netowrk Open. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2792389 Trends in heat related illness: Nationawide observational cohort at the US Department of Veteran Affairs. The Joural of Climate Change and Health. https://www.sciencedirect.com/science/article/pii/S2667278223000561 Heatstroke. New England Journal of Medicine. https://doi.org/10.1056/nejmra1810762 https://www.ready.gov/heat Host: Gerard Clancy, MD Senior Associate Dean for External Affairs Professor of Psychiatry and Emergency Medicine University of Iowa Carver College of Medicine Guest: Melvin Donaldson, MD, PhD Fellow in Emergency Medicine University of Iowa Department of Emergency Medicine Financial Disclosures:  Dr. Gerard Clancy, his guests and the members of the planning committee for Rounding@IOWA have no relevant financial relationships to disclose. CME Credit Designation: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this activity for a maximum of 0.5 ANCC contact hour. Other Health Care Providers: A certificate of completion will be available after successful completion of the course. (It is the responsibility of licensees to determine if this continuing education activity meets the requirements of their professional licensure board.)  

Mind Pump Fit Tip: Do you feel anxious, depressed, or sad? Look at the things you may be lacking in your life. (2:28) Mind Pump Recommends ‘The Ashley Madison Affair' on Hulu. (12:51) The future of dating. (18:42) Kids say the darndest things. (25:57) The inner struggle as a parent. (28:46) The power duo, Brain blend plus caffeine. (33:20) Pool Day with the Di Stefano's. (34:40) The benefits of Tesamorelin. (38:35) The nailing painting robot. (40:34) Tales of a nurse. (42:52) The gymnastics commitment. (45:06) The performance and recovery benefits of cold plunging. (51:30) How fitness changes the way you view aging. (56:10) Adam's family loves Sal. (57:53) The evolution of Mind Pump. (59:57) Shout out to Mind Pump Live! (1:05:03) #ListenerLive question #1 - Why do the insides of my knees hurt when lunging but not squatting? (1:06:31) #ListenerLive question #2 - How do you get started on your journey of finding and working with a functional medicine practitioner? (1:17:46) #ListenerLive question #3 - Is there a program I can purchase that would fit into my schedule and help me reach my goals? (1:26:24) #ListenerLive question #4 - What exercise-related care would you like to see from general physicians? (1:38:39) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit NED for an exclusive offer for Mind Pump listeners! ** Code MINDPUMP at checkout for 15% off ** Visit Plunge for an exclusive offer for Mind Pump Listeners! ** Code MINDPUMP at checkout for $150 off your order ** May Promotion: MAPS Strong | MAPS Powerlift 50% off! ** Code MAY50 at checkout ** Watch The Ashley Madison Affair Streaming Online - Hulu AI personas are the future of dating, Bumble founder says. Mind Pump #2205: Why Dating Sucks & How To Fix It With Adam Lane Smith TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN! Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what's right for you. Target's Nail Painting Robot In Action See and hang out with Mind Pump, LIVE! Saturday, June 15 · 1pm PDT Bellagio Las Vegas. Click the link here for more details. Visit biOptimizers for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP10 at checkout for 10% off your order** Combat Stretch Ankle Mobility - YouTube How to Perform a 90/90 Hip Stretch (HIP FLEXOR STRETCH) Mind Pump #2117: Fix Your Knee Pain MP Holistic Health Mind Pump #1345: 6 Ways To Optimize Sleep For Faster Muscle Gain And Fat Loss Mind Pump #2112: Is 15 Minutes Enough Time For An Effective Workout? Sleep and Injury Risk – PubMed Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Mind Pump Fitness Coaching Course Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Adam | Relationship Psychology (@attachmentadam) Instagram Max Lugavere (@maxlugavere) Instagram Jordan Shallow D.C (@the_muscle_doc) Instagram Jen Cohen (@therealjencohen) Instagram Ben Patrick (@kneesovertoesguy) Instagram Justin Brink DC (@dr.justinbrink) Instagram Dr. Stephen Cabral (@stephencabral) Instagram Andy Frisella (@andyfrisella) Instagram  

Ihr Lieben, mit dieser Folge möchten wir euch und auch uns selbst ein paar stärkende Worte mitgeben! Wir möchten aber auch betonen, dass positive Affirmationen keine Therapie ersetzen können.Solltet ihr also Symptome einer Depression oder depressiven Verstimmung zeigen, wendet euch an: https://www.deutsche-depressionshilfe.de/startPositive Affirmationen in der Episode(00:04:41-00:07:40) Was können positive Affirmationen bewirken?(00:09:37-00:11:13) Gesundheit(00:11:14-00:13:02) Beziehung(00:13:03-00:14:49) Familie und Freundschaft(00:14:49-00:16:38) Finanzen(00:16:38-00:18:22) Karriere und Beruf(00:18:22-00:20:15) Wohnen und Umfeld(00:20:15-00:22:03) Freizeit und Erholung(00:22:05-00:24:06) Persönliche EntwicklungText zum Mitsprechen:https://docs.google.com/document/d/1r_D-YoZPLJn-pmyHMfckE6kYoe8uDQXgDA6I272TsZA/edit?usp=sharingAuswahl Quellen: "Self-affirmation alters the brain's response to health messages and subsequent behavior change" von 2015"Self-Affirmation Improves Problem-Solving under Stress" 2013https://www.researchgate.net/publication/283545154_Self-Affirmation_Activates_Brain_Systems_Associated_with_Self-Related_Processing_and_Reward_and_is_Reinforced_by_Future_Orientation von 20152019: Association of Optimism With Cardiovascular Events and All-Cause Mortality https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777240/2014 Self-Affirmation Promotes Physical Activity https://www.researchgate.net/publication/261256631_Self-Affirmation_Promotes_Physical_ActivityProf. Dr. René Paasch: Unsichtbare Fesseln – Wie Neuroplastizität unsere Denkmuster verändert, 2023 https://www.die-sportpsychologen.de/2023/10/prof-dr-rene-paasch-unsichtbare-fesseln-wie-neuroplastizitaet-unsere-denkmuster-veraendert/https://www.neuromentaltraining.com/neuro-blog/neuroplastizitaet-denken-gehirn/ Möchtest Du Cathrin oder Kim auf einen Kaffee einladen und dafür die Episoden werbefrei hören? Dann klicke auf den folgenden Link: https://plus.acast.com/s/starke-frauen. Hosted on Acast. See acast.com/privacy for more information.

Dr. Casey Means uncovers the ancestral roots of mitochondrial health and discusses the modern-day factors contributing to illness and fatigue. Both Dr. Means and Dr. Stephanie provide invaluable insights and actionable tips for optimizing health.Covering topics such as nutrition, sleep, stress, and lifestyle factors, this conversation offers a wealth of knowledge for listeners at any stage of their health journey. Tune in to discover the secrets to unlocking your full health potential and embarking on a journey to self-optimization.Episode Overview:0:00 Intro/teaser3:45 Unveiling Mitochondrial Health11:58 Healthcare System and Root Cause Issues20:35 Empowering Patients to Take Control25:33 Modern Food, Health, and Technology41:12 Building Meals: Components for Cellular Health38:59 Optimizing Health Through Nutrition and Thermoneutrality43:40 The Impact of Indoor Living on our Biology45:03 Harnessing Cosmic Energy Through Mitochondrial Health46:38 Incorporating Temperature Play into Daily Life50:47 The Importance of Movement and Walking55:33 The Influence of Artificial Light on Circadian Rhythms58:57 Utilizing Wearables to Track Movement1:01:50 Embracing Sunlight and Overcoming Fear1:14:02 Fearlessness as the Ultimate Good Energy1:19:30 Connecting with the Eternal Source of LifeResources mentioned:Good Energy by Dr. Casey Means is a paradigm-shifting book that offers a radical new understanding of the roots of disease and highlights the importance of optimizing our metabolic health.  - https://www.caseymeans.com/goodenergyTrends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018 - https://www.sciencedirect.com/science/article/pii/S0735109722049944?via%3DihubSteps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study - https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783711The Mini Pause newsletter - https://drstephanieestima.com/newsletter/Bio:Casey Means, MD is a Stanford-trained physician and co-founder of Levels, a health technology company with the mission of reversing the world's metabolic health crisis. Her book on metabolic health, Good Energy, comes out in May 2024 with Penguin Random House. She received her BA with honors and MD from Stanford, was President of her Stanford class, and has served on Stanford faculty. She trained in Head & Neck Surgery before leaving traditional medicine to devote her life to tackling the root cause of why Americans are sick. She has been featured in The New York Times, The New Yorker, The Wall Street Journal, Forbes, Women's Health, and more. Find out more at https://www.caseymeans.com/We are grateful to our sponsors:EQUIP PRIME PROTEINEquip Foods Prime Protein is a complete bovine protein with the nutritional equivalent of 4-ounces of grass-fed beef. The best part is, it tastes like dessert, not beef. I use it all the time in my baking efforts when I'm trying to sneak in more protein. Head over to https://equipfoods.com/better and use code BETTER at checkout to get 20% off of your order.PRIMEADINEPrimeadine has been shown to support memory, cognition, heart health, balanced hormones, and improved hair growth and fullness. If you are interested in trying it out, go to https://OxfordHealthspan.com/DrStephanie and use code DrStephanie15 to get 15% off of your order.BIOPTIMIZERS MAGNESIUM BREAKTHROUGHIf you want to get all your magnesium in one supplement, you will love Magnesium Breakthrough. Each supplement itself is 500 milligrams of magnesium, which I feel is such a great dosage as a great baseline for most women. So head on over to https://bioptimizers.com/better and use code BETTER for 10% off of any order, but make sure that the magnesium breakthrough is in your cart.

The Journal of Rheumatology's Editor-in-Chief Earl Silverman discusses this month's selection of articles that are most relevant to the clinical rheumatologist. Patient-reported outcomes and PRO remission rates in 12,262 biologic-naïve patients with psoriatic arthritis treated with TNF-inhibitors in routine care - doi.org/10.3899/jrheum.2023-0764 Relationship Between Adalimumab Concentrations, Antidrug Antibodies, and Disease Activity in Rheumatoid Arthritis: A Cross-Sectional Observational Study - doi.org/10.3899/jrheum.2023-0706 Factors Associated With Treatment Pathways in Early Axial Spondyloarthritis: A Multistate Analysis of the 10-Year Follow-Up of the DESIR Cohort - doi.org/10.3899/jrheum.2023-0933 The Association of Stair Climbing Behaviors With Hazard of All-Cause Mortality in Adults With or At Risk of Knee Osteoarthritis - doi.org/10.3899/jrheum.2023-0818 Effect of Secukinumab and Tumor Necrosis Factor Inhibitors on Humoral Response to BNT162b2 mRNA Vaccine in Patients With Spondyloarthritis Compared to Immunocompetent Controls - doi.org/10.3899/jrheum.2023-0357

Folge ansehen oder anhören auf YouTube I Apple Podcasts I SpotifyDanke an die WerbepartnerEss-Wissen Club für PraktikerDein Schlüssel zu aktuellem Ernährungswissen und Vorlagen für die Praxis14 Tage ohne Risiko testen. Rabatt-Code PODCAST10 und du bekommst 10% auf die Jahresmitgliedschaft.https://esswissen-club.com/Kapitel00:00 Darum geht es in der Folge 01:42 EsssWissen Club für Praktiker Vorstellung 03:04 Begrüßung und EInleitung ins Thema 06:53 Cholesterin und LDL-Cholesterin 11:07 Lean Mass Hyperresponders - Besprechung der speziellen Subgruppe von Personen, die auf kohlenhydratarme oder ketogene Ernährung mit einem erhöhten LDL-Cholesterin reagieren. 17:25 Keine Korrelation zwischen LDL und gesättigten Fetten 17:53 Lipid Energy Model 22:58 Experiment Oreos vs. Statine 28:55 Diskussion der Klinischen Konsequenz Wir sprechen überWir hinterfragen die gängigen Annahmen über LDL-Cholesterin und dessen Rolle bei Herz-Kreislauf-Erkrankungen und beleuchten, wie individuelle Reaktionen auf eine kohlenhydratarme Ernährung das LDL-Cholesterin beeinflussen können. Insbesondere diskutieren wir das Phänomen der sogenannten Lean Mass Hyperresponder, Personen, die bei ketogener Ernährung einen außergewöhnlichen Anstieg des LDL-Cholesterins erleben, und stellen die Frage nach der klinischen Relevanz dieser Veränderungen. Durch die Analyse von Studien und persönlichen Experimenten, wie dem Vergleich der LDL-Cholesterin-Senkung durch Statine versus die Aufnahme von Oreo-Keksen, hinterfragen wir kritisch die traditionelle Fokussierung auf LDL-Cholesterin als primären Risikofaktor. Die drei wichtigsten Takeaways, die du aus dieser Episode mitnehmen wirst, sind:Die komplexe Beziehung zwischen Cholesterin, LDL und Ernährung: Wir entmystifizieren, wie Cholesterin und LDL tatsächlich funktionieren und warum eine pauschale Bewertung und die Einteilung in gutes und böses Cholesterin zu kurz greift.Die spezielle Gruppe der Lean Mass Hyperresponders: Erfahre, warum bestimmte Personen auf eine ketogene Ernährung mit einem unerwartet hohen Anstieg des LDL-Cholesterins reagieren und was das bedeutet.Praktische Ansätze und was die Wissenschaft sagt: Wir teilen die neuesten Erkenntnisse und Studien, die Licht auf diese oft missverstandenen Themen werfen und wir zeigen dir, wie du diese Informationen für deine Gesundheitsziele nutzen kannst.Alles über Ulrike Gonder und Julia TulipanÜber Ulrike Gonder: Dipl. oec. troph. und Freie Wissenschaftsjournalistin https://ulrikegonder.de/ Über Julia Tulipan: Magister der Biologie und Master klinische Ernährungsmedizin https://juliatulipan.com/Relevante ArtikelNorwitz, Nicholas G., et al. "The lipid energy model: reimagining lipoprotein function in the context of carbohydrate-restricted diets." Metabolites 12.5 (2022): 460. https://www.mdpi.com/2218-1989/12/5/460Norwitz, Nicholas G., et al. "Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research." Journal of Clinical Lipidology 16.6 (2022): 765-768. https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextYi, Sang-Wook, Jee-Jeon Yi, and Heechoul Ohrr. "Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults." Scientific reports 9.1 (2019): 1596.https://www.nature.com/articles/s41598-018-38461-yCholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort studySchatz, Irwin J., et al. "Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study." The lancet 358.9279 (2001): 351-355.https://www.readcube.com/library/0ba8445e-192b-440f-8d84-60732183d7ec:9996a2ae-9692-47f3-a3c1-36d4b240516cRavnskov, Uffe, et al. "Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review." BMJ open 6.6 (2016): e010401.https://bmjopen.bmj.com/content/6/6/e010401Rong, Shuang, et al. "Association of Low‐Density Lipoprotein Cholesterol Levels with More than 20‐Year Risk of Cardiovascular and All‐Cause Mortality in the General Population." Journal of the American Heart Association 11.15 (2022): e023690.https://www.readcube.com/library/0ba8445e-192b-440f-8d84-60732183d7ec:8e3bee53-f8e6-44b8-93c9-cb3e86dee086Bevor wir beginnen, möchte ich mich bei meinen Sponsoren bedanken, deren Unterstützung es mir ermöglicht, regelmäßig spannende Inhalte für dich zu erarbeiten.Danke an die Werbepartner, ohne deren Unterstützung dieser Podcast nicht möglich wäre.Ess-Wissen Club für PraktikerDein Schlüssel zu aktuellem Ernährungswissen und Vorlagen für die PraxisBleibst Du gerne auf dem Laufenden, ohne in Studienbergen zu versinken? Der EWiP-Club ist Deine Lösung! Wir filtern, übersetzen und kondensieren die neuesten Ernährungserkenntnisse direkt auf Deinen Schreibtisch - in deutscher Sprache und praxisnah aufbereitet.14 Tage ohne Risiko testen. Rabatt-Code PODCAST10 und du bekommst 10% auf die Jahresmitgliedschaft. https://esswissen-club.com/ Bitte beachten Sie auch immer den aktuellen "Haftungsausschluss (Disclaimer) und allgemeiner Hinweis zu medizinischen Themen" auf https://juliatulipan.com/haftungsausschluss/

My book Reframe Your Brain, available now on Amazon https://tinyurl.com/3bwr9fm8 Find my "extra" content on Locals: https://ScottAdams.Locals.com Content: Politics, All Cause Mortality, Humanizing Robots, ELVIS Act, Haiti Gangs Coordination, Don Lemon, Elon Musk, Michael Harriot, DEI, 8th Amendment, Leticia James, Vivek Ramaswamy, Omnibus, Thomas Massie, Speaker Johnson, Mike Benz, Untouchable Hunter Biden, George Soros, JFK Files, Jack Ruby, Don't Vote Biden Persuasion, Julian Assange, Democrat Beliefs, Scott Adams ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ If you would like to enjoy this same content plus bonus content from Scott Adams, including micro-lessons on lots of useful topics to build your talent stack, please see scottadams.locals.com for full access to that secret treasure. --- Support this podcast: https://podcasters.spotify.com/pod/show/scott-adams00/support

Strong body, strong mind, is a common saying, but the reverse can be true too. How you think can affect your physical health because each and every thought you have is the result of a chemical reaction. In this episode, we discuss how certain thoughts affect performance and health, what happens in your body to make this happen and how to shift to a more positive way of thinking.   Some references cited in the podcast: Association of Optimism with Cardiovascular Events and All-Cause Mortality https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2752100 Become More Optimistic by Imagining a Best Possible Self https://www.sciencedirect.com/science/article/abs/pii/S0005791611000358?via%3Dihub Interactions of momentary thought content and subjective stress predict cortisol fluctuations in a daily life experience sampling study https://www.nature.com/articles/s41598-018-33708-0    

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Email live@mindpumpmedia.com if you want to be considered to ask your question on the show. Mind Pump Fit Tip: If you want bones that don't break, keep lifting weights! (2:48) There is a hierarchy of Sudafed. (16:21) Tombstone is a classic. (22:15) Growing up Gotti. (25:28) Retracing your family tree and heritage. (29:39) Fun Facts with Justin: Anti-Pope. (32:35) Mind Pump's jet lag protocol. (36:22) Seated vs. Standing exercises. (44:10) Add sodium to your diet if you drink reverse osmosis water. (51:22) The first completely wireless television! (54:42) Crazy news with Sal: Nail salon robbery. (58:25) Shout out to a couple of previous Mind Pump guests! (1:00:20) #ListenerLive question #1 - Is it normal to lose muscle mass as well as body fat? (1:01:40) #ListenerLive question #2 - What's the ideal length for a cut for a female? (1:13:48) #ListenerLive question #3 - Any advice on feeling burnt out due to my physical labor job? (1:22:00) #ListenerLive question #4 - What is the appropriate level and intensity of workouts for young athletes? (1:29:25) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com Visit NED for an exclusive offer for Mind Pump listeners! For a limited time only, Mind Pump listeners get a free LMNT Sample Pack with any purchase: Visit DrinkLMNT.com/MindPump November Promotion: MAPS Resistance | MAPS Prime Pro 50% off! **Code NOVEMBER50 at checkout** Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Mind Pump #1547: The Hidden Benefits Of Lifting Weights Watch Get Gotti | Netflix Official Site Growing Up Gotti (TV Series 2004-2005) - IMDb Antipope John XXIII Visit State & Liberty for an exclusive offer for Mind Pump listeners! **Promo code PUMP10 at checkout for 10% off** Z Press to take Your Shoulder Development to the Next Level The ONLY Way You Should Be Doing Dumbbell Bicep Curls! Displace TV Man tries to rob Atlanta nail salon but gets ignored, video shows Building a Non-Anxious Life – Book by Dr. John Delony Forever Strong: A New, Science-Based Strategy for Aging Well – Book by Dr. Gabrielle Lyon Visit biOptimizers for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP10 at checkout** Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial – PubMed Mind Pump #2157: Using Cardio As A Weight Loss Tool Mind Pump #2102: Maximizing Athletic & Cognitive Performance With Dr. Stephen Cabral Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Squat University (@squat_university) Instagram Bishop Robert Barron (@bishopbarron) Instagram Ben Greenfield (@bengreenfieldfitness) Instagram Dr. John Delony (@johndelony) Instagram Dr. Gabrielle Lyon (@drgabriellelyon) Instagram Dr. Stephen Cabral (@stephencabral) Instagram  

In this episode Sal, Adam & Justin speak to Dr. Gabrielle Lyon about the role muscle plays in overall health and longevity. We are not overfat but under-muscled. (1:57) What makes muscle so protective as an organ? (4:51) Why are doctors so slow to change their paradigm of thinking around building muscle? (7:49) How insulin resistance affects the body. (11:47) The disconnect with measuring strength vs. muscle mass. (17:33) If you want to have a healthy brain, MOVE! (22:47) How do we move the needle to get people to lift weights? (27:28) The effect muscle has on hormones. (38:33) Why are nutrition conversations steeped in politics? (46:22) How does building muscle help with organ health? (1:05:45) Why we must stop talking about protein as a generic term. (1:09:19) Creatine is an anti-aging/longevity supplement. (1:14:36) Having concerns over the anti-animal narrative. (1:18:12) The myths surrounding kids and exercise/tech. (1:22:12) How dietary cholesterol can positively affect muscle strength. (1:26:11) Feeling the responsibility to help people and change lives. (1:27:37) How actions will ALWAYS trump words. (1:31:23) Making the case for the benefits of strength training. (1:33:58) You move your body; you move your mind. (1:39:25) A PSA for EVERY trainer out there. (1:40:11) Related Links/Products Mentioned Forever Strong: A New, Science-Based Strategy for Aging Well – Book by Dr. Gabrielle Lyon For a limited time only, Mind Pump listeners get a free LMNT Sample Pack with any purchase: Visit DrinkLMNT.com/MindPump October Promotion: MAPS Bands | The Skinny Guy ‘hardgainer' Bundle 50% off! **Code OCTOBER50 at checkout** Higher weight is linked to poor brain health in children Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies The Midlife Muscle Crisis: why we've gotten obesity all wrong | Gabrielle Lyon | TEDxWestMonroe The Resistance Training Revolution – Book by Sal Di Stefano Strength training can help protect the brain from degeneration D3-creatine dilution for the noninvasive measurement of skeletal muscle mass in premature infants Mind Pump #1835: Why Resistance Training Is The Best Form Of Exercise For Fat Loss And Overall Health Mind Pump #2152: How To Convince Friends & Family To Work Out Mind Pump #2075: The New Science Of Living Longer & Better With Dr. Rand McClain The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment Keto Diet May Improve Fertility in Women with PCOS, Study Finds Stanford historian traces military's influence on U.S. nutrition The food industry pays ‘influencer' dietitians to shape your eating habits Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers Plant Based Diets Won't Help | Peter Ballerstedt PhD – The Dr. Gabrielle Lyon Show Muscle-strengthening activities and cancer incidence and mortality: a systematic review and meta-analysis of observational studies Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Dr. Gabrielle Lyon (@drgabriellelyon) Instagram Dr. Rand McClain (@dr.randmcclain) Instagram Layne Norton, Ph.D. (@biolayne) Instagram Peter Ballerstedt, PhD (@grassbased) Instagram Bedros Keuilian (@bedroskeuilian) Instagram Ed Mylett (@edmylett) Instagram  

As I celebrate my 43rd birthday, it's a time of great reflection. The theme of this year continued to be "The Year of The Opposite.” It's a good time to look back and reflect on what went well and what didn't. Health TriumphsThe year started with a momentous occasion: running my first half-marathon distance on my 42nd birthday in Las Vegas. As the year unfolded, my health milestones were significant. In September 2022, my risk of dying from a cardiac event in the next 10 years showed a dramatic drop from 16% to 2%. Even my doctors were amazed; in that same month, they stopped all my medications and my medical conditions had been resolved! This was one of the proudest days of my life. Year Of The Opposite - Travis Stoliker's Substack is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Continuing my health journey, I achieved a new low weight 177 lbs and raised my VO2 Max from "Below Average" to "High." One study suggests that this cut my risk of dying at any time in half! (Reduction in All Cause Mortality.) With a commitment to running, I logged 1,000 miles in 365 days, and I achieved a sub-7-minute mile along the way. I couldn't have imagined this a year ago when I was incapable of running a short distance around the block. Daring FeatsMy "Opposite Challenges" ranged from physically demanding feats to mind testing experiences. Running continued to be my favorite work out activity. I ran 1 mile backwards, which is way harder than I expected and also incredibly good for your knees. I tackled a 2,000,000 Scoville hot wing by completing the Hot Ones Challenge. I taught myself how to hold my breath for 2 minutes and 44 seconds and I broke my personal record in the 41 degree cold plunge by being able to stay submerged up to my neck for 14 minutes. Cold plunging is one of the best feelings that I have found in the world. I LOVE it! I will be writing a full post about it soon. Professional AchievementsIn the professional sphere, Saddleback BBQ, the restaurant I co-own, received the Michigan 50 Small Businesses To Watch Award which is the most prestigious business award in State. We also accepted the “Certificate of Pure Achievement” from the state of Michigan and we were also honored as the Greater Lansing Business Of The Year. These accolades weren't without their challenges, though. Our Pizza place on Pennsylvania had the front window smashed and the cash register stolen and a brazen robbery where our mobile pizza oven was stolen from our west side location. Luckily, we were able to recover the pizza oven in another city 50 miles away. Community InvolvementCommunity involvement is very important to me so I volunteered for new positions to serve. I joined the Community Board of Ele's Place which is an incredible non-profit that helps children that are dealing with the death of a parent. My 5 year old, Lane, started Kindergarten this year and I was appointed to Trustee of the Haslett School Board. Which also led to my first time expelling a student… not fun. I will be sharing more about my experience on the school board in a post soon. Personal Growth and SkillsOn a personal growth front, I got a Concealed Carry Pistol Permit, learned how to make donuts at Sprinkles Donuts, and even tried my hand at walleye fishing. All of these activities might seem disparate, but they're united in the fact that I would have never done these before my year of the opposite. They were pushing me out of my comfort zone and I was challenging myself. It also led me to meet new people and get a better respect for the views of others. Coping and Self-ImprovementThis year wasn't without its emotional challenges. As you may recall, every night I rate myself on a scale from -2 to +2. +2 representing an amazingly awesome day. -2 representing an awful terrible day. Luckily, last year I was able to turn my mood around quickly after my friends passing by pursuing the Year Of The Opposite. My average rating for age 41 was .72. Which meant that I was in the happy range. Unfortunately, my rating for age 42 slipped a little to .58. Looking back at my journals I can see what happened…After my first Year Of The Opposite was completed in March of 2023, I relaxed some of my rules. I drank alcohol on 18 days and I would occasionally use marijuana with friends. I was trying to test to see what impact this would have on my happiness and performance. Well, the results are in, and they aren't good. There is a inverse correlation between my happiness and me using alcohol and marijuana. My happiness ratings consistently go down in the days following my use of these substances. I was pretty surprised by how stark the effect was. TravelLast year I did a 360 review where I had friends, family, co-workers and business partners rate me and provide feedback about my performance anonymously. I then fed that information into artificial intelligence to have it create a new years resolution list. One of the things that continually came up was that I didn't travel enough. So this year we tried to travel at least once a month. We travelled to numerous places in Michigan and also visited Nashville, Chicago, North Carolina, Buffalo, Pennsylvania, Las Vegas, and Cleveland. (The Schvitz in Chicago and Cleveland are amazing. Thanks Laur!) In summaryIn summary, my 42nd year was a transformative one. I became healthier, braved new challenges, achieved professional milestones, and contributed to my community. As I turn 43, I'm not just a year older but immeasurably enriched, eagerly looking forward to what the next year has in store. Year Of The Opposite - Travis Stoliker's Substack is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Get full access to Year Of The Opposite - Travis Stoliker's Substack at www.yearoftheopposite.com/subscribe

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page.  Mind Pump Fit Tip: When it comes to pursuing your health & fitness goals, there is ONLY the right and wrong way. There is yes and no, NOT fast and slow. (1:41) Muscle itself is extremely protective and contributes to longevity. (11:56) Looking at health through a different lens. (21:37) Adam's problem with medical professionals on social media. (28:22) Mad respect for Deion Sanders. (37:46) Legion has stacks! (42:27) The evolution of the Mind Pump Newsletter. (44:08) Mind Pump's Conspiracy Corner. (46:46) Shout out to Michael Churnow. (53:20) #Quah question #1 - What's the best way to build shoulders when you have difficulty with the mind-muscle connection? (54:54) #Quah question #2 - Is age-related muscle loss expected due to hormones or is it because most people become lazy and sedentary as they age? I don't want to be dependent on TRT or stuff like that as I age. (1:00:04) #Quah question #3 - Can you do a segment on recovery management strategies? What factors, indicators, or metrics can be used to measure recovery, and what mitigations can be applied to reduce injury risk and promote consistent workout performance? (1:10:13) #Quah question #4 - I have a personal training business. What is the best advice you can give to someone who is trying to spread awareness for their fitness brand and build it? (1:18:38) Related Links/Products Mentioned Visit Legion Athletics for the exclusive offer for Mind Pump listeners! **Code MINDPUMP at checkout for 20% off** Visit Kreatures of Habit: Meal One for an exclusive offer for Mind Pump listeners! **Code MP25 at checkout** September Promotion: MAPS Symmetry | RGB Bundle 50% off! **Code SEPTEMBER50 at checkout** Mind Pump #1297: 3 Ways To Know If Your Workout Is Not Right For You Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults Live to 100: Secrets of the Blue Zones - Netflix Mind Pump #1887: Why You Shouldn't Ask Your Doctor About Diet & Exercise The food industry pays ‘influencer' dietitians to shape your eating habits Study Finds Significant Chemical Exposures in Women With Cancer Watch Coach Prime – Season 1 | Prime Video Evidence-based Analysis on Supplements & Nutrition | Examine Mind Pump Newsletter Nationwide test of FEMA emergency alerts scheduled for Wednesday October 4, 2023 X account suspended after predicting Aaron Rodgers' Achilles injury with creepy precision The Dark Meaning of "Californication" by The Red Hot Chili Peppers Mind Pump #1902: From Addict To Self-Made Millionaire With Michael Chernow Visit Butcher Box for this month's exclusive Mind Pump offer! Mind Pump #1950: Shoulder Building Masterclass Improve Your Overhead Press & Build Your Shoulders with Unilateral Kettlebell Carries – Mind Pump TV Fix Your Shoulder Pain (SHORT & LONG TERM FIX!!) | MIND PUMP TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what's right for you. Mind Pump Hormones Facebook Private Forum What Lifestyle Factors Are Linked to Depression? Mind Pump #1870: Ten Advanced Recovery Hacks Mind Pump #1770: How Sleep Helps Your Muscles Recover And Grow Visit Eight Sleep for an exclusive offer for Mind Pump Listeners! **Save $150 on the Pod Cover.** Mind Pump #2155: The Art & Science Of Building Perfect Butts With Bret Contreras Mind Pump #2172: Five Commandments For Successful Personal Trainers Mind Pump #2170: Inside The Mind Of A World Class Personal Trainer With Jordan Syatt Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Dr Idrees Mughal (MBBS, MRes, DipIBLM) (@dr_idz) Instagram Layne Norton, Ph.D. (@biolayne) Instagram @COACHPRIME (@deionsanders) Instagram Mike Matthews (@muscleforlifefitness) Instagram Michael Churnow (@michaelchernow) Instagram Bret Contreras PhD (@bretcontreras1) Instagram  

It's Monday and Health Freedom News and Views! We're talking about the Defender newsletter's top stories of the week with Stephanie Locricchio. Stephanie Locricchio is the Advocacy and Outreach Manager at CHD (Children s Health Defense). She works to amplify the voices of those fighting for issues impacting the health and freedom of our children. Stephanie provides support, encouragement, and action steps advocates can take to build the more beautiful world we want our children to live in. Find all the stories they discuss on the Children's Health Defense website, or get ahead of the game by signing up to have the Defender newsletter sent to your inbox. If you want to stop the power grab please visit the Children's Health Defense and sign the petition!Here are just a few of the stories they talk about:‘Definite Causal Link' Between COVID Vaccine Rollouts and Peaks in All-Cause Mortality, New Study FindsUN President Approves Pandemic Declaration — Privacy Experts Warn of ‘Digital Gulag'Emergency Calls for ADHD Medication Errors Up 299%, Researchers Say 1 Drug May Be Partly to BlameThank you to our sponsors!Enviromedica – Rewild your gut with spore-based probiotics and wild-harvested prebiotics designed to support a healthy and diverse microbiome.Cardio Miracle - A comprehensive heart and health supplement utilizing over 50 ingredients. Visit cardiomiracle.com today for an automatic 15% OFF your order! Children's Health Defense - Listen every Monday as we cover the top stories from the CHD‘s Defender NewsletterSunwarrior - Use the code OLR for 20% off your purchase!Well Being Journal - For nutritional, mental, emotional, social, and spiritual health.Thorne - Get 20% off your order and free shipping!

In this episode Sal, Adam & Justin cover five things that can indicate your weight loss may not be the kind you want. The challenge of losing weight and thinking you're doing things the right way. (1:26) We don't just want to lose weight but change body composition. (3:58) How muscle is EXTREMELY protective. (7:31) Five Things that can Indicate your Weight Loss May Not be the Kind you Want. #1 - You lose muscle. (8:12) #2 - You develop a nutrient deficiency. (18:32) #3 - You do it unsustainably. (24:32) #4 - You do it through dysfunctional behaviors. (31:11) #5 - You feel worse. (39:48) Related Links/Products Mentioned Visit Seed for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 30% off your first month's supply of Seed's DS-01® Daily Synbiotic** September Promotion: MAPS Symmetry | RGB Bundle 50% off! **Code SEPTEMBER50 at checkout** Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies HANDGRIP DYNAMOMETER Mind Pump #1387: Turning Your Body Into A Fat-Burning Machine Mind Pump #2035: Why Diets Always Fail With Dr. Will Cole Mind Pump #1915: How To Re-Ignite Your Metabolism Workout Because You Love Yourself Not Because You Hate Yourself – Mind Pump Blog Mind Pump Podcast – YouTube Mind Pump Free Resources  

Jared is joined on this episode of Vitality Radio by Dr. Pierre Kory. If you don't know who Dr. Kory is yet, this is your opportunity to hear what an impactful figure he has been in the fight against medical censorship, and for early treatment protocols for covid, as well as treatment for vaccine injury. Dr. Kory has written a book about the all out attack that was made on Ivermectin and other repurposed drugs over the last few years. Jared and Dr. Kory discuss his book and how scientific journals and the whole medical system have been hijacked by the pharmaceutical industry.Additional Information:Dr. Pierre KoryFLCCC Alliance The War On Ivermectin - book by Dr. Pierre KoryYour Health Freedom SymposiumVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

On today's show, Bernadette covers Top News and Views of the Week from The Defender Newsletter and the Children's Health Defense with Ray Flores. Ray Flores is a leading health freedom attorney. After graduating from UCLA in the 1980s, he found his 1st calling in the natural products business. He became an attorney in 2004 to protect health from being attacked by regulatory agencies. He NOW serves as senior outside counsel and represents Children's Health Defense in several groundbreaking lawsuits. Read the articles they discuss on the Children's Health Defense website, or get ahead of the game by signing up for the Defender newsletter.  Here are just a few of the stories they talk about:Infant Vaccines Linked to Increase in All-Cause Mortality, New Research ShowsExclusive: Survivor of CDC COVID Protocols Says She Was ‘Just a Paycheck'Musk's X Corp. Sues Authors of ‘Disinformation Dozen' Report Over Alleged ‘Scare Campaign'Thank you to our sponsors!Cardio Miracle - A comprehensive heart and health supplement utilizing over 50 ingredients. Visit cardiomiracle.com today for an automatic 15% OFF your order! Enviromedica – Rewild your gut with spore-based probiotics and wild-harvested prebiotics designed to support a healthy and diverse microbiome.Children's Health Defense - Listen every Monday as we cover the top stories from the CHD‘s Defender NewsletterSunwarrior - Use the code OLR for 20% off your purchase!Well Being Journal - For nutritional, mental, emotional, social, and spiritual health.Thorne - Get 20% off your order and free shipping!

Lege Sjur Even Aunmo er opptatt av å følge med på forskning. I denne episoden forteller han om problemene med å leve av planter. Planter har nemlig forsvarsmekanismer mot å bli spist. De kan dessuten stjele mineraler, trigge immunsystemet, tilføre tungmetall og gi næring til kreft. Selv foretrekker han et kosthold bestående utelukkende av animalske produkter. Han synes det er beklagelig at rådene har blitt politiske gjennom at de har tatt inn klimasaken, fremfor at de er en mest mulig sann fremstilling av hva ulike typer mat gjør med kroppen. Aunmo legger frem forskningsevidens som peker i motsatt retning av kostholdsrådene norske myndigheter har lagt frem nylig. Han har mange suksesshistorier fra pasienter med autoimmune sykdommer, diabetes og andre sykdommer, som har blitt friske etter at de sluttet å spise bestemte typer planter, produkter fra planter eller utelukket dem helt fra kosten.Sjur Even Aunmo: • youtube.com • facebook.comGrønnsaker uten noen kjent form for gluten: • hodekål, blomkål, brokkoli, paprika, rødbeter, bladbete, squash, potet, søtpotet, gulrøtter, gresskar, romano-salat, indisk bladsennep, spinat, grønnkål • Obs: Selv om disse plantene ikke inneholder gluten, finnes det andre stoffer i dem som er uheldige. Paprika, for eksempel, hører til søtvier-familien, sammen med potet og tobakk. De forsvarer seg mot mennesker, dyr og insekter med lektiner og solanin. Spinat inneholder mye oksalat som stjeler kalsium fra kroppen. Det finnes igjen i nyrestener og mistenkes for å stimulere brystkreft. Grønnsaker inneholder druesukker, som er et viktig næringsstoff for kreft. Grønnsaker som vokser over bakken inneholder ofte mindre sukker enn de som vokser under bakken. De minst usunne grønnsakene på listen synes å være hodekål, blomkål og brokkoli, på tross av at disse danner goitrin, et stoff som motvirker dannelsen av stoffskiftehormon.Diverse kilder: • Mindre kjøtt, mer plantebasert: Her kommer De nordiske ernæringsanbefalingene 2023 • Helsedirektoratets kostråd • The Seven Countries Study (søk) • Paleo diet (søk) • Keto diet (søk) • Carnivore diet (søk)› Relaterte AJP-episoder: • AJP 61 | Sjur Even Aunmo – Fikk sparken for å snakke om bivirkningerRelatert forskning:› FETT› https://doi.org/10.1136/bmj.e8707 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis› https://doi.org/10.1136/bmj.i1246 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)› https://doi.org/10.3945/ajcn.2009.27725 Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease› https://doi.org/10.1186/s12937-017-0254-5 The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials› https://doi.org/10.1016/j.jacc.2020.05.077 Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review› http://dx.doi.org/10.1136/openhrt-2014-000196 Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis› http://dx.doi.org/10.1136/bmjebm-2019-111180 Fat or fiction: the diet-heart hypothesis› https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html› https://doi.org/10.1046/j.1471-4159.1997.68052092.x 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease› https://doi.org/10.1016/j.freeradbiomed.2006.07.021 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids› https://doi.org/10.1038/s41467-018-05614-6 Dietary stearic acid regulates mitochondria in vivo in humans› http://dx.doi.org/10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health› https://doi.org/10.1194/jlr.M026179 Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells› https://doi.org/10.1021/jf049207s Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER (KOLESTEROLSENKENDE STOFFER)› http://dx.doi.org/10.1136/bmjopen-2018-023085 Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews› http://dx.doi.org/10.1136/bmjopen-2014-007118 The effect of statins on average survival in randomised trials, an analysis of end point postponement› https://doi.org/10.1001/archinternmed.2010.182 Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants› https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999› https://www.felleskatalogen.no/medisin/zocor-organon-565655› https://www.legemiddelhandboka.no/L8.15.1/Statiner› https://www.bmj.com/campaign/statins-open-data Statins - a call for transparent data› https://doi.org/10.1001/archinternmed.2011.625 Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› https://doi.org/10.1007/s40264-017-0620-4 Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System› https://doi.org/10.1001/jamainternmed.2020.6084 Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years› https://doi.org/10.1016/j.atherosclerosis.2022.07.003 Statin therapy for the primary prevention of cardiovascular disease: Cons› http://doi.org/10.1161/STROKEAHA.121.034576 Lipid-Lowering Therapy and Hemorrhagic Stroke RiskLipid-Lowering Therapy and Hemorrhagic Stroke Risk› KJØTT› https://www.acpjournals.org/doi/full/10.7326/M19-0622 Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials› https://doi.org/10.3945/ajcn.116.142521 Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› https://doi.org/10.3945/ajcn.113.062638 Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies› FISK› https://doi.org/10.1093/jn/nxab112 Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children› https://doi.org/10.1007/s12016-013-8363-1 Fish Allergy: In Review› KOLESTEROL› http://dx.doi.org/10.1136/bmjopen-2015-010401 Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review› https://doi.org/10.1016/j.mehy.2018.09.019 Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia› PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis› https://doi.org/10.1016/0021-9150(89)90130-5 Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages› https://doi.org/10.1161/01.CIR.93.7.1346 Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL› https://doi.org/10.1161/01.CIR.97.20.2012 Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein› https://doi.org/10.1016/j.atherosclerosis.2008.04.046 Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review› https://doi.org/10.1161/ATVBAHA.113.300156 Smoking and Cardiovascular Disease› https://doi.org/10.3402/fnr.v59.29240 LDL biochemical modifications: a link between atherosclerosis and aging› https://doi.org/10.1016/j.cjca.2017.07.015 Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› https://doi.org/10.1054/plef.2000.0204 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study.› KARBOHYDRAT› https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› FRUKTOSE› https://doi.org/10.1016/j.jhep.2021.02.027 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial› https://doi.org/10.1093/ajcn/nqaa332 Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› https://doi.org/10.5223/pghn.2021.24.5.483 The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity› KUNSTIG SØTNING› https://doi.org/10.1016/s0378-8741(99)00081-1 Effects of chronic administration of Stevia rebaudiana on fertility in rats› https://doi.org/10.1371/journal.pone.0000698 Intense Sweetness Surpasses Cocaine Reward› https://doi.org/10.1016/j.cell.2022.07.016 Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance› https://doi.org/10.1289/ehp.8711 First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats› https://doi.org/10.1289/ehp.10271 Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats› DIABETES› https://doi.org/10.1001/jama.295.6.655 Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett› https://doi.org/10.3945/ajcn.110.010843 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial› https://doi.org/10.1007/s11745-008-3274-2 AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet› https://doi.org/10.1161/ATVBAHA.114.303284 Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort› https://doi.org/10.1097/MOL.0b013e328306a057 Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology› https://doi.org/10.1016/0021-9150(93)90084-8 Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?› https://doi.org/10.2337/diabetes.55.02.06.db05-1103 Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› https://doi.org/10.1016/S0895-7061(00)01260-7 Blood viscosity and blood pressure: role of temperature and hyperglycemia› https://doi.org/10.2337/dc13-1374 Blood Viscosity in Subjects With Normoglycemia and Prediabetes› https://doi.org/10.1007/s00592-017-1004-z Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity› https://doi.org/10.1080/09674845.2010.11730293 Blood viscosity at different stages of diabetes pathogenesis.› DIABETES-DEMENS› https://doi.org/10.1212/WNL.53.9.1937 Diabetes mellitus and the risk of dementia - The Rotterdam Study› https://doi.org/10.1016/S1474-4422(05)70284-2 Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review› https://doi.org/10.1111/j.1445-5994.2012.02758.x Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies› https://doi.org/10.1016/j.arr.2019.100944 Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies› https://doi.org/10.1177/193229680800200619 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed› https://doi.org/10.3390/ijerph120708281 Evaluating the Association between Diabetes, Cognitive Decline and Dementia› https://doi.org/10.3390/ijms21030934 Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model› https://doi.org/10.1038/s41574-018-0048-7 Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications› https://doi.org/10.1038/s41586-020-2247-3 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline› DIABETES NYRESYKDOM› https://doi.org/10.2337/diacare.27.2007.S79 Nephropathy-in-Diabetes Nephropathy in Diabetes› Diabetic Nephropathy: Diagnosis, Prevention, and Treatment› https://doi.org/10.1016/S0272-6386(96)90538-7 Diabetic nephropathy in type II diabetes› DIABETES ØYESYKDOM› https://doi.org/10.1016/S0140-6736(09)62124-3 Diabetic retinopathy› https://doi.org/10.1016/S2213-8587(18)30128-1 Incidence and progression of diabetic retinopathy: a systematic review› DIABETES HJERTE- OG KAR-SYKDOM› https://doi.org/10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF, VERN OG GIFT› https://doi.org/10.1016/j.foodchem.2008.01.056 Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols› https://doi.org/10.1002/mnfr.200900099 Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis.› https://doi.org/10.1046/j.1440-6047.1999.00038.x Oxalate content of foods and its effect on humans› https://doi.org/10.1104/pp.109.2.347 Lectins as plant defense proteins.› https://doi.org/10.1016/j.taap.2009.03.012 Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› https://doi.org/10.1038/s41531-018-0066-0 Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› https://doi.org/10.1016/S0140-6736(05)79894-9 Identification of intact peanut lectin in peripheral venous blood› https://doi.org/10.1136/bmj.318.7190.1023 Do dietary lectins cause disease?› https://doi.org/10.1016/S0015-0282(16)54596-8 Lectin binding of endometrium in women with unexplained infertility› https://doi.org/10.1016/S0271-5317(88)80133-7 Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins› https://doi.org/10.3390/molecules20022014 Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection› https://doi.org/10.1210/endo-113-6-1921 Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities› https://doi.org/10.1042/BJ20071137 Contribution of leptin receptor N-linked glycans to leptin binding› https://doi.org/10.1111/j.1365-2249.2007.03368.x Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E› https://doi.org/10.1002/(SICI)1521-4141(199903)29:03 Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils› https://doi.org/10.1016/j.ekir.2018.07.020 Secondary Oxalate Nephropathy: A Systematic Review› http://dx.doi.org/10.1136/gut.16.3.193 The effect of tea on iron absorption.› PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.› https://doi.org/10.1016/0887-2333(95)00113-1 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro› https://doi.org/10.1079/BJN2002725 The biological action of saponins in animal systems: a review› http://doi.org/10.1093/carcin/bgp082 Lung tumor promotion by curcumin› https://doi.org/10.3945/ajcn.2009.26736M Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)› https://doi.org/10.3382/ps.0550716 Antithyroid Activity of Goitrin in Chicks› https://doi.org/10.1016/s0278-6915(82)80294-9 Hepatic effects of R-goitrin in in Sprague-Dawley rats› https://doi.org/10.1002/ana.24448 Vagotomy and subsequent risk of Parkinson's disease --> https://doi.org/10.1038/s41531-018-0066-0› Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› http://doi.org/10.1056/NEJMra2010852 Salicylate Toxicity› https://doi.org/10.1021/jf0113070 Relationship between Cyanogenic Compounds in Kernels, Leaves, and Roots of Sweet and Bitter Kernelled Almonds› https://doi.org/10.1179/146532810X12637745451951Cyanide poisoning caused by ingestion of apricot seeds› https://doi.org/10.3390/toxins11060324 Ricin: An Ancient Story for a Timeless Plant Toxin› https://doi.org/10.1016/j.taap.2009.03.012Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› GLUTEN› https://doi.org/10.1080/00365520500235334 Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines› https://doi.org/10.1053/j.gastro.2008.03.023 Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3› https://doi.org/10.1016/j.jprot.2017.03.026 A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods› https://doi.org/10.1111/jgh.13703 What is gluten?› https://doi.org/10.1186/s41043-015-0032-y The opioid effects of gluten exorphins: asymptomatic celiac disease› https://doi.org/10.1016/j.peptides.2015.07.013 Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects› SOYA› https://doi.org/10.1271/bbb.70516Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities.› TILSETNINGSSTOFFER› https://doi.org/10.3233/NHA-170023 A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity› https://doi.org/10.1053/j.gastro.2021.11.006 Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome› https://doi.org/10.1002/ijc.21925 Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women› KETOGENISITET/KREFT› https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse› https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html› https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect› https://doi.org/10.1016/j.tibs.2015.12.001 The Warburg Effect: How Does it Benefit Cancer Cells?› https://doi.org/10.1080/01635581.2019.1650942 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study› https://doi.org/10.1093/jnci/djs399 Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803› https://doi.org/10.18632/aging.101382 Ketogenic diet in cancer therapy› IATROGENISITET› https://doi.org/10.1111/eci.12834 How to survive the medical misinformation mess› https://doi.org/10.1111/jlme.12068 Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs› https://doi.org/10.1136/bmj.f3830 Why we can't trust clinical guidelines› https://doi.org/10.1016/S0140-6736(15)60696-1 Offline: What is medicine's 5 sigma?› https://apjcn.nhri.org.tw/server/apjcn/procnutsoc/1990-1999/1995/1995%20p1-10.pdfLast ned episodenInnspilt: 2023-07-18Publisert: 2023-07-28Støtte Antijantepodden?Liker du arbeidet vi gjør, og vil bidra til at vi lager flere episoder?Finn ut hvordan du kan gi noe tilbake ved å gå til antijantepodden.com!Meld deg på vårt nyhetsbrev

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom.  2116: How to Break Through a Deadlift Plateau, Ways to Maintain Progress When Circumstances Dramatically Cut Available Training Time, How to Judge if You Are Gaining Weight Too Quickly & More (Listener Live Coaching)  Mind Pump Fit Tip: It's healthier to be fat and have muscle, than to be skinny and have no muscle. (2:31)  Cannabis for fat loss! (8:21)  The older generation was built differently. (15:47)  Some thoughts on the Supreme Court's reversal of affirmative action. (23:02)  The potential outcomes for transgender women in sports. (35:02)  You never know what someone is going through. (41:13)  An update on the current state of the economy and Mind Pump Rentals. (46:01)  Sal updates the audience on more groundbreaking research in Ketamine therapy and busting the stigma surrounding it. (50:33)  How protein powders can be valuable for vegans. (57:57)  Shout out to Robert Oberst. (59:32)  #ListenerLive question #1 – Do you have any tips on how to maintain as much of my progress as possible, when my overall activity and training volume decreased significantly? (1:01:25)  #ListenerLive question #2 - Is there a way I can modify MAPs Powerlift to help push my deadlift, and what does that look like? (1:11:29)  #ListenerLive question #3 – Is there a way to build more muscle, as a woman, to get past that bulky phase? (1:22:20)  #ListenerLive question #4 - Did I gain weight too fast (roughly 18 pounds in 3 months), and should I decrease the number of calories I am eating? (1:35:30) Related Links/Products Mentioned  Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com  Visit NED for an exclusive offer for Mind Pump listeners!  Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout**  July Promotion: MAPS Starter | MAPS Starter Bundle 50% off! **Code JULY50 at checkout**  The Resistance Training Revolution – Book by Sal Di Stefano  Marijuana users less likely to be overweight, obese  Active Component Of Marijuana Has Anti-cancer Effects, Study Suggests  Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies  What the Supreme Court's ruling on affirmative action does and does not do  All-In Podcast - E135: Wagner rebels, SCOTUS ends AA, AI M&A, startups gone bad, spacetime warps & more  Excluding Trans Women From Women's Hockey: Examining The Roots  Fall in Airbnb listings revenues sparks housing market crash fears  Ketamine for a boost of neural plasticity: how, but also when?  What is EMDR? - Eye movement desensitization and reprocessing  The Righteous Gemstones | Season 3 Now Streaming - Max  Visit Legion Athletics for the exclusive offer for Mind Pump listeners! **Code MINDPUMP at checkout for 20% off**  How Much Training is Necessary to Maintain Strength and Muscle?  MAPS 15 Minutes  MAPS Powerlift  MAPS Symmetry  Mind Pump #1790: The Secret To An Attractive & Functional Body  Mind Pump #1565: Why Women Should Bulk  Mind Pump #1057: How To Get Stronger For Fat Loss & Muscle Building  TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN! Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what's right for you.  Mind Pump Podcast – YouTube  Mind Pump Free Resources People Mentioned  Robert Oberst (@robertoberst) Instagram  Jen Thompson (@jenthompson132) Instagram  Dr. Stefi Cohen, DPT (@steficohen) Instagram

Tato epizoda je čtrnáctým dílem ze série „Study News“, která se věnuje hlubšímu rozboru zajímavých studií, které nás nějakým způsobem zaujaly. První studie pojednává o tom, jaký vliv má pohybová aktivita ve studené vodě na náš apetit. Druhá studie je věnovaná pozorování rizika užívání alkoholu na úmrtí. Jsme rádi, že se vám tento koncept líbí! Přejeme příjemný poslech. Naši tvorbu můžeš podpořit nákupem suplementů Za Hranicí Fitness, využitím slevového kódu při nákupu u našich partnerů, nebo také sdílením, či recenzí na Apple Podcastech. Děkujeme za jakoukoliv formu podpory! Suplementy Za Hranicí Fitness najdeš na: ZAHRANICIFITNESS.cz/ESHOP Na celém e-shopu můžeš využít 5% slevový kód - ZAHRANICI5 Partneři podcastu MITOLIGHT.cz - 10% slevový kód - ZAHRANICI10 Brainmarket.cz - 10% slevový kód - ZAHRANICI10 Instagram - @zahranicifitness Facebook - Za Hranicí Fitness YouTube - Za Hranicí Fitness Web Podcastu - zahranicifitness.cz Reference 1) Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis 2) Association Between Daily Alcohol Intake and Risk of All-Cause Mortality

In this episode Sal, Adam & Justin speak with movement specialists Kelly and Juliet Starrett. The politicization of health & fitness. (2:12) The biggest problem with the fitness space. (10:52) The universal language of strength training. (15:17) The importance of tracking your vital signs. (20:29) How to combat being jet lagged on Monday. (24:39) Taking the systems approach with their clients. (30:09) Balancing beliefs and rituals with high-level athletes. (34:23) The ultimate performance hack for athletes. (39:00) How do you feel? Managing data points. (42:12) Why you should be in bed for 9 hours. (51:50) The depressant/stimulant cycle. (54:54) #LittleDoses. (1:02:30) Making walking ‘rad' again. (1:11:38) Adding balance into your life. (1:24:43) Our poor relationship with inputs/outputs of feeling things. (1:34:04) Taking pain off the output table. (1:40:18) Who did they write the book for? (1:43:58) What tools & hacks do they back? (1:45:15) How do you ‘win' health? (1:50:03) Related Links/Products Mentioned Built to Move: The Ten Essential Habits to Help You Move Freely and Live Fully Visit MASSZYMES by biOptimizers for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP10 at checkout** March Promotion: “Time-crunch Bundle” (MAPS 15 Minutes, MAPS Anywhere, MAPS Prime + Eat for Performance eBook ALL for only $99.99!! Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Mind Pump #1345: 6 Ways To Optimize Sleep For Faster Muscle Gain And Fat Loss Becoming a Supple Leopard 2nd Edition: The Ultimate Guide to Resolving Pain, Preventing Injury, and Optimizing Athletic Performance Mind Pump #1927: Performance Training Secrets From A Top NBA Trainer With Cory Schlesinger What is NEAT and Why Should You Care About it? - Mind Pump Blog Exercise interventions for the prevention of depression: a systematic review of meta-analyses Spark: The Revolutionary New Science of Exercise and the Brain – Book by John Ratey New pediatric guidelines on obesity in children and teens Do You Have Enough Balance to Pass This 60-Second 'Old Man Test'? 800g Challenge | Fruit & Vegetable Diet Plan Mind Pump #1825: Man Cheats Death & Builds Cold Plunge Business Visit SleepMe for an exclusive offer for Mind Pump listeners! Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest(s)/People Mentioned Kelly Starrett (@thereadystate) Instagram Juliet Starrett (@julietstarrett) Instagram Andrew Huberman, Ph.D. (@hubermanlab) Instagram Andy Galpin (@drandygalpin) Instagram Eric Cressey (@ericcressey) Instagram Stuart McMillan (@StuartMcMillan1) Twitter Dan Pfaff (@simplifaster) Instagram Coach Burgener (@mikeburgener) Instagram   Kate Courtney (@kateplusfate) Instagram Mark Bell (@marksmellybell) Instagram Katy Bowman (@nutritiousmovement) Instagram Chris Hinshaw (@aerobiccapacity) Instagram Joe DeFranco (@defrancosgym) Instagram Justin Brink DC (@dr.justinbrink) Instagram EC Synkowski (@optimizemenutrition) Instagram Ryan Duey (@ryanaduey) Instagram Wim Hof (@iceman_hof) Instagram

Episode HighlightsHow sauna use has the potential to reduce risk of all cause mortality, heart disease and many other issues. The history of sauna use and how many cultures have used heat therapy since 2000 B.C.What the different types of saunas are (dry sauna, steam sauna, and infrared sauna) and how they workWhich sauna is bestWhat heat shock proteins are and how sauna impacts thisThe benefits of sweatingHow sauna can impact heart health, detoxification, muscle recovery, mood, weight loss, and more!Timing of sauna use and what time of the day is typically recommendedExamples of how I use sauna during the week, what temperature, how long, and what kindHow often you should use a sauna and how to beginResources MentionedSunlighten Sauna - Mention wellnessmama for a discountCreatrix SaunaBarrel SaunaClearlight SaunaHigherDOSE Sauna Blanket - Use code wellnessmama15 for a discountLMNTThanks to Our Sponsor:Wellnesse - My line of clean and non-toxic personal care products such as toothpaste, deodorant, shampoo and much more!

Furosemide is the most prescribed loop diuretic for heart failure; however, furosemide's pharmacokinetic parameters are less than ideal compared to other loop diuretics. Join host, Geoff Wall, as he evaluates the first randomized controlled trial comparing loop diuretics in heart failure.The GameChangerTorsemide has potential pharmacokinetic advantages compared to furosemide in the treatment of heart failure. However, a recent study did not find meaningful differences in clinical outcomes when comparing loop diuretics for the treatment of heart failure.Show Segments00:00 - Introduction01:00 - Current Loop Diuretic Use02:21 - Furosemide vs Torsemide Pharmacokinetics04:58 - Looking at the TRANSFORM-HF Study14:54 - The GameChanger: TRANSFORM-HF Outcomes19:16 - Connecting to Practice: Picking Between the Two21:52 - Closing RemarksHostGeoff Wall, PharmD, BCPS, FCCP, CGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint HealthReferences and ResourcesEffect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial. Redeem your CPE hereCPE (Pharmacist)Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)Pharmacists: Get a membershipCE InformationLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. List the pharmacokinetic differences between furosemide and torsemide2. Discuss the findings of the Mentz et al study evaluating loop diuretics0.05 CEU/0.5 HrUAN: 0107-0000-23-101-H01-PInitial release date: 02/27/2023Expiration date: 02/27/2024Additional CPE and CME details can be found here.Follow CEimpact on Social Media:LinkedInInstagramDownload the CEimpact App for Free Continuing Education + so much more!

What Are They Hiding?—Dr. Robert Malone on the Pfizer Documents and Evidence of Cardiotoxicity, Birth Defects, and the Rise in All-Cause Mortality

The loop diuretic duels, adverse events during hospital admissions, BP accuracy, and, again, left main revascularization strategies (again) are the topics John Mandrola discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. TRANSFORM HF Clarity on Torsemide vs Furosemide in HF: TRANSFORM-HF Published https://www.medscape.com/viewarticle/987128 • Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure https://jamanetwork.com/journals/jama/fullarticle/2800428 • RANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? https://jamanetwork.com/journals/jama/fullarticle/2800445 II. Adverse Events in the Hospital Adverse Events Reported in One Quarter of Inpatient Admissions https://www.medscape.com/viewarticle/987091 • The Safety of Inpatient Health Care https://www.nejm.org/doi/full/10.1056/NEJMsa2206117 III. BP Accuracy Experts Demand Validation of Automatic Blood Pressure Devices https://www.medscape.com/viewarticle/987032 IV. Left Main Coronary Artery Disease Real-World Examination of Revascularization Strategies for Left Main Coronary Disease in Ontario, Canada https://doi.org/10.1016/j.jcin.2022.10.016 Management of Left Main Coronary Artery Disease in Nonemergent Settings: The Heart of Multidisciplinary Teamwork https://doi.org/10.1016/j.jcin.2022.11.024 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Chris HooverTrade Goods and Services with Flip Flop - https://flip-flop.us/Help Support Free America!Subscribe - www.FreeAmericaPodcast.comFollow - https://www.instagram.com/freeamericapodcast/Support - Get your Covid's Most Wanted cards here! With 20% OFF and FREE SHIPPING!https://www.etsy.com/shop/CovidsMostWanted?coupon=PODCAST Edward Dowd Video - https://www.youtube.com/watch?v=NCGO9kuYM0M News Itemshttps://www.thegatewaypundit.com/2022/10/fully-vaxxed-boosted-cdc-director-walensky-tests-positive-covid-rebound-case-taking-paxlovid/https://expose-news.com/2022/10/25/58k-children-injured-covid-vaccination-in-the-usa/https://www.theatlantic.com/ideas/archive/2022/10/covid-response-forgiveness/671879/https://www.theepochtimes.com/health/virus-hits-71-vaxxed-over-unvaxxed_4836431.html?src_src=News&src_cmp=breaking-2022-11-04-1&est=NUOaj7v%2B1gR8OXNRvan5ZBgx%2FkcKazYs8X3TeKls6FLff%2B%2FoxzzHkuAAmgCpj5Q%3Dhttps://childrenshealthdefense.org/defender/americans-harvested-cellphone-data-covid-lockdowns/https://www.thegatewaypundit.com/2022/10/legal-scientists-london-lab-just-created-mutant-super-strain-covid-reportedly-lethal/https://www.thegatewaypundit.com/2022/11/tsa-extends-ban-unvaccinated-travelers-entering-us-next-year-one-last-countries-follow-guideline-along-china/https://www.thegatewaypundit.com/2022/11/not-post-watch-world-economic-forum-spiritual-leader-explain-exactly-society-conciously-choose-depopulate-compulsion-child/https://www.thegatewaypundit.com/2022/10/discovered-facebook-twitter-private-portals-democrats-government-officials-corporate-elites-meet-ban-unwanted-conservative-content/

In this episode of Quah (Q & A), Sal, Adam & Justin coach four Pump Heads via Zoom. Mind Pump Fit Tip: The BEST form of exercise to directly combat the aging process is strength training! (2:13) Fyre Fest's Billy McFarland is out of prison and back at it! (9:00) Alec Baldwin is tone-deaf. (11:46) Selective outrage and Kanye West. (13:15) An example of when you don't think things out. (25:34) Food hacks with Butcher Box. (32:17) The food industry is a brutal business. (33:21) Gas-powered all day! (39:03) NYC employees were reinstated for not getting vaccinated. (40:50) Is Jake Paul the future of boxing? (45:03) Technology is cool. (46:52) PRx's new feature and Mind Pump's ideal gym. (49:47) The potential anti-cancer effects of creatine. (54:20) #ListenerLive question #1 - How do you lose fat without losing weight? (57:51) #ListenerLive question #2 - If I keep lifting light instead of lifting to my max every workout, does this help in the long term in preventing those knots I had? (1:13:07) #ListenerLive question #3 - How do you guys recommend incorporating running with your weightlifting programs? (1:25:07) #ListenerLive question #4 - What is the best way to lift weights as a boxer? (1:33:13) Related Links/Products Mentioned Ask a question to Mind Pump, live! Email: live@mindpumpmedia.com MIND PUMP LIVE Q&A W/ MAX LUGAVERE Visit Butcher Box for this month's exclusive Mind Pump offer! Visit PRx Performance for an exclusive offer for Mind Pump listeners! November Promotion: MAPS OCR or MAPS Cardio HALF OFF! **Promo code NOVEMBER50 at checkout** Dr. Andy Galpin Post on Strength Training Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Billy McFarland, Fresh Out Of Prison After The Fyre Fest Fiasco, May Be Trying To Launch Another Festival For Some Reason ALEC BALDWIN GETS DRAGGED FOR TONE-DEAF POST ABOUT SHOOTING A WOMAN A YEAR AGO Billionaire No More: Kanye West's Antisemitism Obliterates His Net Worth As Adidas Cuts Ties Mississippi daycare workers fired after screaming at children in Halloween mask LUNA Mexican Kitchen VISCONTI'S RISTORANTE Biden Infrastructure Bill Mandates Vehicle Kill Switches By 2026 Court Orders New York City To Reinstate Unvaccinated Employees Dyson is developing robots that do household chores Exploratory studies of the potential anti-cancer effects of creatine Visit LivON Labs for an exclusive offer for Mind Pump listeners! MAPS Strong MAPS Powerlift Mind Pump #1932: Lifting Heavy Vs. Lifting Light MAPS Symmetry MAPS Prime Webinar Mind Pump #1925: How To Build A Great Physique In 15 Minutes A Day MAPS 15 Minutes   MAPS Fitness Performance   Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Dr. Andy Galpin (@drandygalpin) Instagram Jake Paul (@jakepaul) Instagram

What Are They Hiding?—Dr. Robert Malone on the Pfizer Documents and the Rise in All-Cause Mortality. “They knew of many of these risks and adverse events… and yet never formally disclosed them to patients,” says mRNA vaccine pioneer Dr. Robert Malone. “I think there are many in the legal profession that are looking at this and raising questions about whether, in fact, this does meet the criteria of fraud in terms of withholding information.” I sit down with Dr. Malone, co-founder of the International Alliance of Physicians and Medical Scientists, to discuss the Global COVID Summit's recent declaration to “end the national emergency, restore scientific integrity, and address crimes against humanity.” Watch this interview at- https://youtu.be/yZfBC6Pnblo 33,981 views Oct 26, 2022 American Thought Leaders - The Epoch Times 348K subscribers ～～～～～～～～～～～～～～～～～～～～～～～～～～～～ *This episode originally premiered on

Pulmonary embolism, coffee, when DOACs don't work, lipoprotein (a), and the marginal benefits of current CV therapy are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Pulmonary Embolism - Positive Data on Thrombectomy Catheter That Avoids Thrombolytics in Acute PE https://www.medscape.com/viewarticle/981322 - Acute Outcomes for the Full US Cohort of the FLASH Mechanical Thrombectomy Registry in Pulmonary Embolism https://eurointervention.pcronline.com/article/acute-outcomes-for-the-full-us-cohort-of-the-flash-mechanical-thrombectomy-registry-in-pulmonary-embolism - PEERLESS Study https://clinicaltrials.gov/ct2/show/NCT05111613 - Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism (HI-PEITHO) https://clinicaltrials.gov/ct2/show/NCT04790370 - A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism: The FLARE Study https://doi.org/10.1016/j.jcin.2018.12.022 II. Coffee Again - Coffee Linked to Reduced Cardiovascular Disease and Mortality https://www.medscape.com/viewarticle/981518 Enough With the Coffee Research and Other Distractions https://www.medscape.com/viewarticle/883709 - The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank https://doi.org/10.1093/eurjpc/zwac189 III. DOAC and Mechanical Valves - PROACT Xa Trial of Apixaban With On-X Heart Valve Stopped https://www.medscape.com/viewarticle/981644 - Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial https://investors.artivion.com/news-releases/news-release-details/artivion-follows-recommendation-stop-proact-xa-clinical-trial - PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban https://clinicaltrials.gov/ct2/show/NCT04142658 - Dabigatran versus Warfarin in Patients with Mechanical Heart Valves https://www.nejm.org/doi/full/10.1056/nejmoa1300615 IV. Lipoprotein(a) - Aspirin Primary Prevention Benefit in Those With Raised Lp(a)? https://www.medscape.com/viewarticle/981602 - Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes https://www.jacc.org/doi/full/10.1016/j.jacc.2022.07.027 - A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women https://www.nejm.org/doi/full/10.1056/nejmoa050613 - Effect of Aspirin on Disability-free Survival in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1800722 - Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1805819 - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1803955 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact: news@medscape.net

Faut-il vraiment faire 10.000 pas par jour pour garder la santé ? Cette semaine, Julie Kern fait le point sur cette affirmation, en confrontant plusieurs études scientifiques et les facteurs qu'elles prennent en compte. Alors, 5.000 ou 10.000 pas ? La réponse est dans La Santé Sur Écoute !

Statin drugs are the highest selling class of pharmaceutical drugs of all time. Yet their success is built on a statistical shell game that amounts to a worldwide lie. Should you allow your GP to coerce you into taking a statin? What does the research reveal?

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page. Mind Pump Fit Tip: Extreme fitness and extreme performance are NOT healthy! (2:59) Throwing shade on serotonin being the leading indicator of depression. (20:41) The humor in watching your kids develop. (31:07) The disconnect between young athletes and their body awareness. (33:45) The ultimate muscle preservation tool. (43:19) Imagining the war of the future. (45:12) A sign of the times for future car purchases. (51:47) Sal's dream PRx garage gym. (58:45) #Quah question #1 - How long does it take to build muscle mass? (1:03:05) #Quah question #2 - Can you explain carb cycling and its benefits? Can you fat cycle as well? (1:14:49) #Quah question #3 - Is there a set point for our weight? (1:24:23) #Quah question #4 - What are some training tips with a newborn? (1:30:01) Related Links/Products Mentioned Visit Paleo Valley for an exclusive offer for Mind Pump listeners! **Promo code MINDPUMP15 at checkout for 15% discount** Visit PRx Performance for an exclusive offer for Mind Pump listeners! July Promotion: RGB Bundle or MAPS Suspension 50% off! **Promo code JULY50 at checkout** Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies How to Balance Your Social Life With a Healthy Lifestyle – Mind Pump Blog Mind Pump #1560: Woke Fitness Is Making You Fat & Unhealthy No Evidence That Depression Is Caused by Low Serotonin Levels The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma Strengthen your mood with weight training – Harvard Health SCIENTISTS SUPERCHARGE HUMAN MUSCLE CELLS BY INJECTING THEM WITH "BEAR SERUM" Robot Dog With Machine Gun | cybernews.com Black Mirror: Metalhead BMW starts selling heated seat subscriptions for $18 a month Europe will require carmakers to install speed limiters from 2022 Visit Serenity Kids for an exclusive offer for Mind Pump listeners! **Promo code MP20 at checkout** Mind Pump #1717: Why Before & After Pictures Are Bullsh*T Carb Cycling: A Good Way To Lose Fat? - Mind Pump Blog Mind Pump #1830: Five Steps To Determine Your Ideal Caloric Intake MAPS Macro Calculator Mind Pump #1322: What's Your Real Muscle Building Potential? (And How To Get There…) Mind Pump #1452: Your 10 Minute Workout For The Holiday Season Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Kris Gethin (@krisgethin)  Instagram

Thanks to Tippsy Sake for sponsoring this episode! Use code ADAM 10％ off all products, and code ADAM30 for $30 off your first Sake Box: https://www.tippsysake.com/discount/ADAM This episode summarizes a scholarly exchange in the journal Advances in Nutrition regarding polyunsaturated fats (such as those obtained from "industrial seed oils) and their impact on human health. We begin with this 2021 paper by Dr. Glen Lawrence: "The Saturated Fat-Unsaturated Oil Dilemma: Relations of Dietary Fatty Acids and Serum Cholesterol, Atherosclerosis, Inflammation, Cancer, and All-Cause Mortality": https://pubmed.ncbi.nlm.nih.gov/33693484/ Next is this letter-the-editor rebutting Lawrence's paper by Dr. Martha Belury, Dr. Emilio Ros and Dr. Penny Kris-Etherton, "Weighing Evidence of the Role of Saturated and Unsaturated Fats and Human Health": https://academic.oup.com/advances/article-abstract/13/2/686/6556254 And this rebuttal letter by Dr. Jeff Moore: "The Dietary Guidelines Are Correct: Saturated Fat Should Be Limited and Replaced with the Proposed Alternatives to Reduce Morbidity and Mortality": https://academic.oup.com/advances/article-abstract/13/2/688/6556255 Finally, Dr. Lawrence's rebuttal to the rebuttals: "Reply to MA Belury et al. and J Moore": https://academic.oup.com/advances/article-abstract/13/2/690/6556307 Here's an earlier (2018) scholarly article on this subject that I found to be very helpful general background: "Dietary fat and cardiometabolic health: evidence, controversies, and consensus for guidance": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053258/ 00:00 Introduction 04:07 Definitions of key terms and other background 17:58 Why the panic is spreading 29:39 Deep dive on the science

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave. KILDER:› COVID-19 • https://clinicaltrials.gov/ct2/show/NCT04368728 • https://clinicaltrials.gov/ct2/show/NCT04470427 • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase • https://covid-nma.com/vaccines/variants/ • https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche • How significant is the Ventavia scandal? • Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial • CDC-vurdering av Modernas studie • https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/ • https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22 • https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine ◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/ ◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf ◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001 ◦ Mandatory Reporting of Infectious Diseases by Clinicians ◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018 ◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384 ◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall? ◦ The illusion of evidence based medicine ‧ Amerikanske Centers for Disease Control om underrapportering ‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering ‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering ‧ Fra det amerikanske registrerings-systemet VAERS om deres system ‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects? ‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.› FETT • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis • Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease • The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials • Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review • http://dx.doi.org/10.1136/openhrt-2014-000196 • Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine • https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html • 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease • https://doi.org/10.1016/j.freeradbiomed.2006.07.021 ◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications ◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health ◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells ◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER • BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews • The effect of statins on average survival in randomised trials, an analysis of end point postponement • JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants • https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999 • https://www.felleskatalogen.no/medisin/zocor-organon-565655 • https://www.legemiddelhandboka.no/L8.15.1/Statiner • Statins - a call for transparent data - The BMJ • Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› KJØTT • Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials • Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› KOLESTEROL • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review • Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia • PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis ◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages ◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL ◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein ◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review ◦ Smoking and Cardiovascular Disease ◦ LDL biochemical modifications: a link between atherosclerosis and aging ◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› KARBOHYDRAT • https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› DIABETES • JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett • AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial • AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet • Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort • Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology • Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? • Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› DIABETES-DEMENS • AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens • Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens • Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review • Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort • JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed • MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia • Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020 • Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018 • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020› HJERTE- OG KAR-SYKDOM • 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF OG VERN • Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols • Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75. • Oxalate content of foods and its effect on humans • Lectins as plant defense proteins • Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction • Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat • Identification of intact peanut lectin in peripheral venous blood • Do dietary lectins cause disease? BMJ • Lectin binding of endometrium in women with unexplained infertility • Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins • Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection • Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities • Contribution of leptin receptor N-linked glycans to leptin binding • Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E • 3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils • Secondary Oxalate Nephropathy: A Systematic Review • The effect of tea on iron absorption • PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116. • Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro • The biological action of saponins in animal systems: a review • Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial ◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.› LEKK TARM • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines • Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 • AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction • 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases› LAVKARB • Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors • BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials • AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial • JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss • NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity • Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial • Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial • Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents • Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial • Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents • Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial› FRUKTOSE • JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial • Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› KETOGENISITET/KREFT • https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse • https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html • https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect • The Warburg Effect: How Does it Benefit Cancer Cells? • NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study • Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803 • Ketogenic diet in cancer therapy› IATROGEN SKADE • https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handteringOpptaksdato: 2022-05-02Publiseringsdato: 2022-05-22Last ned episoden

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave. KILDER:› COVID-19 • https://clinicaltrials.gov/ct2/show/NCT04368728 • https://clinicaltrials.gov/ct2/show/NCT04470427 • Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine • Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase • https://covid-nma.com/vaccines/variants/ • https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche • How significant is the Ventavia scandal? • Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial • CDC-vurdering av Modernas studie • https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/ • https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22 • https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine ◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/ ◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf ◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001 ◦ Mandatory Reporting of Infectious Diseases by Clinicians ◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018 ◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384 ◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall? ◦ The illusion of evidence based medicine ‧ Amerikanske Centers for Disease Control om underrapportering ‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering ‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering ‧ Fra det amerikanske registrerings-systemet VAERS om deres system ‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects? ‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.› FETT • Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis • Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73) • Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease • The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials • Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review • http://dx.doi.org/10.1136/openhrt-2014-000196 • Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine • https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html • 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease • https://doi.org/10.1016/j.freeradbiomed.2006.07.021 ◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications ◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health ◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells ◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER • BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews • The effect of statins on average survival in randomised trials, an analysis of end point postponement • JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants • https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999 • https://www.felleskatalogen.no/medisin/zocor-organon-565655 • https://www.legemiddelhandboka.no/L8.15.1/Statiner • Statins - a call for transparent data - The BMJ • Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› KJØTT • Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials • Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› KOLESTEROL • Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review • Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia • PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis ◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages ◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL ◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein ◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review ◦ Smoking and Cardiovascular Disease ◦ LDL biochemical modifications: a link between atherosclerosis and aging ◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› KARBOHYDRAT • https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› DIABETES • JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett • AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial • AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet • Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort • Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology • Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? • Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› DIABETES-DEMENS • AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens • Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens • Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review • Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort • JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed • MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia • Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020 • Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018 • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020› HJERTE- OG KAR-SYKDOM • 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF OG VERN • Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols • Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75. • Oxalate content of foods and its effect on humans • Lectins as plant defense proteins • Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction • Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat • Identification of intact peanut lectin in peripheral venous blood • Do dietary lectins cause disease? BMJ • Lectin binding of endometrium in women with unexplained infertility • Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins • Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection • Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities • Contribution of leptin receptor N-linked glycans to leptin binding • Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E • 3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils • Secondary Oxalate Nephropathy: A Systematic Review • The effect of tea on iron absorption • PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116. • Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro • The biological action of saponins in animal systems: a review • Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial ◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.› LEKK TARM • Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines • Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3 • AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford) • FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction • 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases› LAVKARB • Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors • BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials • AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial • JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss • NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity • Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial • Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial • Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents • Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial • Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents • Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial› FRUKTOSE • JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial • Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› KETOGENISITET/KREFT • https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse • https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html • https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect • The Warburg Effect: How Does it Benefit Cancer Cells? • NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study • Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803 • Ketogenic diet in cancer therapy› IATROGEN SKADE • https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handteringDownload this episodeRecorded: 2022-05-02Published: 2022-05-22

Ischemia vs anatomic testing for CAD, UK-TAVI trial, TAVI for AR? and post-PCI anti-thrombotics are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I – Ischemic vs Anatomic Evaluation for CAD - ISCHEMIA Substudy Data Just Don't Add Up, Cardiac Surgeons Say https://www.medscape.com/viewarticle/974107 - Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.049755 - Initial Invasive or Conservative Strategy for Stable Coronary Disease https://www.nejm.org/doi/full/10.1056/nejmoa1915922 - Forget Ischemia: It's All About the Plaque https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.054102 - Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.107.743963 - Baseline stress myocardial perfusion imaging results and outcomes in patients with stable ischemic heart disease randomized to optimal medical therapy with or without percutaneous coronary intervention https://doi.org/10.1016/j.ahj.2012.05.018 - Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease https://www.nejm.org/doi/full/10.1056/nejmoa1415516 - Coronary CT Angiography and 5-Year Risk of Myocardial Infarction https://www.nejm.org/doi/full/10.1056/NEJMoa1805971 - Five Reasons I Don't Believe an Imaging Test Improves Outcomes https://www.medscape.com/viewarticle/901204 II – UK-TAVI Trial - UK TAVI: Similar Outcomes to Surgery in Real World https://www.medscape.com/viewarticle/927729 - Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis https://jamanetwork.com/journals/jama/fullarticle/2792251 III – TAVI for AI? - JenaValve Trilogy Takes Another Step Forward in Severe AR https://www.medscape.com/viewarticle/974304 IV – Post PCI DAPT - One-Month DAPT Enough for Complex PCI if Bleeding Risk High https://www.medscape.com/viewarticle/974224 - Duration of Antiplatelet Therapy After Complex Percutaneous Coronary Intervention In Patients at High Bleeding Risk: a MASTER DAPT trial sub-analysis https://doi.org/10.1093/eurheartj/ehac284 - Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk https://www.nejm.org/doi/full/10.1056/NEJMoa2108749 Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Malone on the Pfizer Documents and Evidence of Cardiotoxicity, Birth Defects, and the Rise in All-Cause Mortality

Malone on the Pfizer Documents and Evidence of Cardiotoxicity, Birth Defects, and the Rise in All-Cause Mortality

O retorno do bolus com Joanne e Marcela falando sobre AAS na profilaxia primária para doença cardiovascular (DCV)! Elas abordam 3 tópicos: - História de AAS na prevenção de DCV - Recomendação atual e os principais estudos que motivaram a mudança de recomendação (ASPREE, ARRIVE E ASCEND) - O que fazer com quem já usa? Tá imperdível! Referências: 1. Aimo A, De Caterina R. Aspirin for primary prevention of cardiovascular disease: Advice for a decisional strategy based on risk stratification. Anatol J Cardiol. 2020;23(2):70-78. 2. Berger JS. Aspirin for Primary Prevention—Time to Rethink Our Approach. JAMA Netw Open.2022;5(4):e2210144. 3. Bowman L, et al. Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus. N Engl J Med 2018; 379:1529-1539 4. Chiang KF, Shah SJ, Stafford RS. A Practical Approach to Low-Dose Aspirin for Primary Prevention. JAMA. 2019;322(4):301-302 5. Gaziano JM, et al. Aspirin to Reduce Risk of Initial Vascular Events - ARRIVE. Lancet 2018; 392: 1036–46 6. McNeil JJ, et al. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med 2018; 379:1519-1528 7. Précoma DB, Oliveira GMM, Simão AF, Dutra OP, Coelho OR, Izar MCO, Póvoa RMS, et al. Atualização da Diretriz de Prevenção Cardiovascular da Sociedade Brasileira de Cardiologia – 2019. Arq. Bras. Cardiol. 2019;113(4):787-891 8. Raber I, et al. The rise and fall of aspirin in the primary prevention of cardiovascular disease. Lancet 2019; 393: 2155–67 9. US Preventive Services Task Force. Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement. JAMA.2022;327(16):1577–1584.

Interview with Aniruddh P. Patel, MD, author of Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality, and M. Benjamin Shoemaker, MD, author of Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes. Hosted by Sadiya Sana Khan, MD, MS.

Interview with Aniruddh P. Patel, MD, author of Association of Pathogenic DNA Variants Predisposing to Cardiomyopathy With Cardiovascular Disease Outcomes and All-Cause Mortality, and M. Benjamin Shoemaker, MD, author of Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes. Hosted by Sadiya Sana Khan, MD, MS.

Aspirin for primary prevention, time-restricted feeding, renal denervation, and a potential new obesity drug are the topics John Mandrola, MD, covers in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I – ASA for Primary Prevention: - USPSTF Final Recommendation on Aspirin for Primary CV Prevention https://www.medscape.com/viewarticle/972761 - Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement https://jamanetwork.com/journals/jama/fullarticle/2791399 - Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/10.1056/NEJMoa1805819 - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1803955 II – Time Restricted Feeding - Is There a Benefit to Fasting Plus Calorie Counting? https://www.medscape.com/viewarticle/972579 - Calorie Restriction with or without Time-Restricted Eating in Weight Loss https://www.nejm.org/doi/full/10.1056/NEJMoa2114833 - Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity. The TREAT Randomized Clinical Trial https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771095 III – Renal Denervation - Renal Denervation BP Benefits Remain at 3 Years: SPYRAL HTN-ON https://www.medscape.com/viewarticle/971883 - Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial https://doi.org/10.1016/S0140-6736(22)00455-X IV – Tirzepatide for Obesity - Tirzepatide Excites in Obesity Now Too, Says Lilly https://www.medscape.com/viewarticle/972936 - Lilly's tirzepatide delivered up to 22.5% weight loss in adults with obesity or overweight in SURMOUNT-1 https://www.prnewswire.com/news-releases/lillys-tirzepatide-delivered-up-to-22-5-weight-loss-in-adults-with-obesity-or-overweight-in-surmount-1--301534871.html You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Meet “Dr. Plant-Based”! Our latest Plant Based Canada Podcast episode is with Muzammil Ahmad, a fourth year medical student with a masters in psychology, certification in nutrition and a bachelor's in business. He believes more times than not, we should be prescribing our patients with a healthy lifestyle over prescribed medications. And he believes a healthy lifestyle starts with a healthy diet rich in whole plant-foods. On his Instagram (@dr.plantbased) and on his website (www.drplantbased.ca), he shares evidence-based nutrition and showcases what a healthy diet looks like, how to incorporate a healthy diet in one's lifestyle and the role of diet in prevention, treatment and in certain cases reversal of chronic lifestyle diseases. He is also passionate about living a sustainable and conscious life that reduces our carbon footprint on the planet and living with compassion and kindness.We also have an exciting update to share, Muzammil will be speaking at our upcoming virtual Canadian Plant Based Nutrition Conference on May 28th and 29th 2022 where he will be sharing more about a #plant-based #lifestyle in relation to #athletics.Our annual conference provides #evidence-based education by Canadian experts on plant-based nutrition for individual health, as well as highlighting the environmental and social concerns of our food system. Sign up to our newsletter on our website or stay tuned on our social media to be kept up to date on the content and ticket sales. In this episode Muzammil covers:His plant-based experience and lifestyle as a medical studentHow “Dr. Plant-Based” beganBlue ZonesTransforming a reactionary approach to medicineCurrent and surprising plant-based evidenceSocial Media Use as a PlatformContent developmentFuture plansEpisode Resources (Articles):Blue Zones: Lessons From the World's Longest Lived Dietary Patterns and Longevity: Expanding the Blue ZonesTen Years of Life: A Matter of Choice? Vegetarian Dietary Patterns and Mortality in Adventist Health Study 2Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of observational studiesVegetarian diets, circulating miRNA expression and health span in subjects living in the Blue ZoneDeterminants of All-Cause Mortality and Incidence of Cardiovascular Disease (2009 to 2013) in Older Adults: The Ikaria Study of the Blue ZonesMuzammil Ahmad's Socials:IG handle: @dr.plantbasedTikTok: @muzammil_medWebsite: www.drplantbased.ca Plant-Based Canada's Socials:InstagramFacebookWebsite  Thank you for tuning in! Make sure to subscribe to the Plant-Based Canada Podcast so you get notified when new episodes are published. This episode was hosted by Stephanie Nishi RD, PhD & Cassandra Carey, MSc, and edited by Clint Stamatovich. 

In this episode, Sal, Adam & Justin interview Aaron Alexander. The current state of Aaron. (2:12) The reality of becoming the shape of the place you spend a lot of time in. (6:03) Defining the outcomes you prefer to achieve, and reverse engineering your lifestyle back from that point. (8:31) How much of an improvement can you make in your movement as an adult? (11:48) Practical advice for the average person looking to make improvements in their daily lives. (14:52) Why structured workouts don't matter much if you haven't addressed your fundamental lifestyle conditions. (21:55) The driving force behind his latest book. (26:36) The staple movements he loves to put the body in and why. (27:44) Why do we breathe the way that we breathe? (31:54) The practices he has for his clients to help with anxiety and depression. (41:15) Why he left Los Angeles. (50:21) Do not be afraid to ask more questions. (53:50) Why the worst thing to happen is nothing at all. (59:10) The value in building strong mental patterns. (1:03:55) What is pain? (1:09:55) Does he see a renewed interest in people wanting to improve their health and fitness? (1:17:32) Related Links/Products Mentioned February Promotion: MAPS Performance and MAPS Aesthetic 50% off!! **Promo code “FEB50” at checkout** Visit Super Coffee for an exclusive offer for Mind Pump listeners! **Promo code “MINDPUMP” at checkout** African hunter-gatherers prefer squatting to sitting — and this may explain why they're healthier Shoulder Pain? The Solution & Prevention, Revised & Expanded – Book by John M. Kirsch M.D. Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Align Podcast: Bruce Lipton: Why Your Consciousness Creates your Biology Breath: The New Science of a Lost Art – Book by James Nestor Shut Your Mouth and Save Your Life: The Dangers of Mouth Breathing and Why Nose or Nasal Breathing is Preferred, Based on the Native American Experience – Book by George Catlin The Oxygen Advantage: The Simple, Scientifically Proven Breathing Techniques for a Healthier, Slimmer, Faster, and Fitter You – Book by Patrick McKeown Amy Cuddy: Your body language may shape who you are | TED Talk Good posture is important for physical and mental health Mind Pump #1490: How To Improve Your Posture Average undesired weight gain reported by adults in the United States since the start of the COVID-19 pandemic as of Feb. 2021, by demographic Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Aaron Alexander (@alignpodcast)  Instagram Aaron Alexander Website Dr. John Kirsch Bruce H. Lipton, PhD Pavel Tsatsouline (@strongfirst)  Instagram Patrick McKeown (@buteykoclinic)  Instagram Wim Hof (@iceman_hof)  Instagram Steven Lin (@drstevenlin)  Instagram Andrew Huberman, Ph.D. (@hubermanlab)  Instagram Dr. John Sarno

The advent of wearable devices that track daily step count has provided not only population-based weight loss guidelines, but also recommendations for cardiovascular improvement.  Prior physical activity national guidelines recommended at least 150 minutes per week of moderate-to-vigorous-intensity exercise – which did not quantify stepping intensity with mortality risk.Until now, most research has been targeted to an older demographic versus a younger, racially diverse population. Researchers, from a diverse group of investigators, chose to estimate the association of steps per day with premature age in Black and White men and women ages 41 to 65.The prospective cohort study- Steps per Day and All-Cause Mortality in Middle-Aged Adults in the Coronary Artery Risk Development in Young Adults, which appeared in the online edition of JAMA Network Open in September 2021, was part of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Participants, age 38 to 50 years, wore an accelerometer on the hip for seven consecutive days during all waking hours from 2005 to 2006. Participants were followed for 10.8 years. Data was analyzed in 2020 and 2021 – with an objective to establish mortality status.Step volume was categorized as: less than 7,000 steps/day as low, 7,000 to less than 10,000 as moderate, and greater than 10,000 daily steps as high. Participants, or designed family members, were contacted twice yearly to determine vital status. Requests were made, where applicable, for death certificates, hospital records for death, and autopsy reports.When the data was compiled, the investigators determined that, “in this cohort study of Black and White middle-aged women and men, higher daily steps were associated with a lower risk of all-cause mortality. Adults taking at least 7000 steps/d, compared with those taking fewer than 7000 steps/d, had approximately 50% to 70% lower risk of mortality. Taking more than 10,000 steps/d was not associated with further reduction in mortality risk.”It was concluded that, “taking at least 7000 steps/d during middle adulthood was associated with a lower risk of mortality. There was no association of step intensity with mortality. Improving physical activity levels in the least active segment of the population by encouraging increasing steps/d may be associated with lower mortality risk.”Photo by Jeremy Bishop on Unsplash

THE THESIS: God almighty has heard our prayers for the lies to be exposed. As is so often the case, the Lord is using the evil-doers to His glory.  THE SCRIPTURE:  Exodus 5 THE MONOLOGUE: The mRNA-Mask Cult made Fauci their god  Claire Lehman, founder of the Quilette, still thinks we are all “conspiracy theorists” for believing there was any evil involved in the planning & execution of this global PsyOp. “I follow of lot of smart people who are skeptical about mainstream Covid policies without being conspiratorial about it. What disturbs me is not policy skepticism, but the constant implication that something conspiratorial is going on, that the ‘elites' are out to get us . . . It's simply another form of identity politics that flattens reality; obscuring more than clarifying.” Yeah … the elites are a REAL GROUP and they ARE OUT TO GET US, even if only for profit → Military Documents About Gain of Function Contradict Fauci Testimony Under Oath BREAKING: Military Documents About Gain of Function Contradict Fauci Testimony Under Oath Dept. Of Defense documents establish Fauci directed gain of function research on SARS-Covid 19 virus.  In 2018.  THE NEWS: Brett Bayer got the okay sign to ask this question → Director Walensky says CDC will provide data on "how many of the 836,000 deaths in the U.S. linked to Covid are from Covid or how many are with Covid," and adds "Omicron has just been with us for a few weeks." CNN's Jake Tapper rips into "misleading" COVID hospitalization numbers. -- "We're 2 years into this ... if somebody's in the hospital with a broken leg and they also have asymptomatic COVID, that should not be counted as hospitalized with covid, clearly." CNN's Brian Stelter: “It's so sad, but it's true, the CDC has turned into a punchline.” When you've lost CNN's chief propagandist... you've truly, truly lost. Our next feature is brought to you by … ? Here's the thug boss of Pfizer → Two doses of the vaccine offers very limited protection, if any. 3 doses with a booster offer reasonable protection against hospitalization and deaths. Less protection against infection.” The DAY AFTER CHRISTMAS, The Fauxch said he was in favor of Big Pharma traveling papers if you want to fly in a commercial airplane  If you THINK that's all … it's not. Listen to the next hour to hear about a 40% increase in ALL CAUSE MORTALITY in America of WORKING AGE PEOPLE!  MUSIC REVIEW: Runaway Feeling - The Thorns See omnystudio.com/listener for privacy information.

In this month's AJP Audio, Dr. Samuel Wilkinson (Yale University, Associate Director of the Yale Depression Research Program) discusses a study looking at the association of electro-convulsive therapy or ECT on all-cause mortality and suicide in Medicare patients with mood and bipolar disorders.  Following that, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the December issue of AJP.   Wilkinson interview: Effects of ECT on older patients with mood disorders [00:50] A brief history of ECT [01:20] A troubled history [02:00] A backlash against ECT [02:24] Improved techniques and practices [03:32] Limitations of past research into ECT [04:20] Strength of the study [05:33] How patients were matched [05:59] Limitations of the present study [07:17] Treatment of patients going forward [08:18] Difficulties in administering and accessing ECT [09:49] Next steps in research into ECT and patients with elevated suicide risk [11:14] All-cause mortality and ECT [11:57] Kalin interview: The December issue of AJP [13:02] Major depressive and bipolar disorders [13:13] “Neuromodulation Strategies for the Treatment of Depression” [13:42] “Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients” [14:19] “Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial” [15:29] Ostacher editorial [17:44] “Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies” [18:18] Pariante editorial [20:42] “Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis” [21:23] Putting the issue into context [23:00]   Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the May 2021 issue. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org  

Aspirin for primary prevention, induced hypothermia, half-dose DOAC, and social media, are the topics John Mandrola, MD, discusses in this week's podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I - ASA for Primary Prevention - USPSTF Rules Out Aspirin for Over 60s in Primary CVD Prevention https://www.medscape.com/viewarticle/960745 - Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication https://www.uspreventiveservicestaskforce.org/uspstf/document/draft-evidence-review/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication - Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31924-X/fulltext - Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus https://www.nejm.org/doi/full/10.1056/nejmoa1804988 - Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1805819 - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/nejmoa1803955 II - Induced Hypothermia - No Benefit From Lower Temps for Out-of-Hospital Cardiac Arrest https://www.medscape.com/viewarticle/961191 - The CAPITAL CHILL Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2785263 - Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa1310519 - Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest https://www.nejm.org/doi/full/10.1056/NEJMoa2100591 III - Half-dose DOAC - Half-Dose DOACs Cut Bleeding, Thrombus Risk Post-Watchman LAA Closure https://www.medscape.com/viewarticle/960974 - Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion https://www.jacc.org/doi/full/10.1016/j.jcin.2021.07.031 IV - Social Media - Navigating Benefits, Pitfalls of Social Media as a Female Doctor https://www.medscape.com/viewarticle/961150 - Gender Differences in Physician Use of Social Media for Professional Advancement https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779868 Features: - USPSTF Statement on Aspirin: Poor Messaging at Best https://www.medscape.com/viewarticle/961118 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

How many steps are associated with a longer, healthier life? 7,000? 10,000? More? Fewer? Do we know the answer? And what about when your healthy behaviors leave you tired? What could be behind THAT unfortunate dynamic? Let's chat!!   LET'S TALK THE WALK! Wellness While Walking Facebook page Wellness While Walking on Instagram Wellness While Walking on Twitter Wellness While Walking website for show notes and other information Coach Carolyn on Clubhouse: @stepstowellness wellnesswhilewalking@gmail.com   RESOURCES AND SOURCES (some links may be affiliate links)   7,000 STEPS A DAY FOR A LONGER LIFE, STUDY SAYS Ep 26, Wellness While Walking: 10,000 Steps: Myth or Mandate? The Big Number: 7,000 Steps Could Help You Reach a Longer, Life Study Says, washingtonpost.com How Many Steps A Day Should You Take? Study Finds 7,000 Can Go a Long Way, nbcnews.com Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronoary Artery Risk Developmet in Young Adults Study, jamanetwork.com (the actual study we're talking about!) What Are the Next Steps for Developing a National Steps Guideline? jamanetwork.com Validity of Activity Monitor Step Detection is Related to Movement Patterns, pubmed.ncbi.nlm.nih.gove HEALTH HABITS MAKING YOU TIRED? How Your Healthy Lifestyle Can Be Making You Tired, cnn.com   How To Share Wellness While Walking Wellness While Walking on Apple  Wellness While Walking on Spotify Link for any podcast app: pod.link/walking Wellness While Walking website Or screenshot a favorite episode playing on your phone and share to social media! Thanks for sharing! : )       DISCLAIMER   Neither I nor most of my podcast guests are doctors or healthcare professionals of any kind, and nothing on this podcast or associated content should be considered medical advice. The information provided by Wellness While Walking Podcast and associated material, by Whole Life Workshop and by Bermuda Road Wellness LLC is for informational and entertainment purposes only. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment, and before undertaking a new health care regimen, including walking.     Thanks for listening to Wellness While Walking, a walking podcast.    

Hvordan har pandemien påvirket den vitenskapelige publiseringen? Hva vet vi om forekomst, behandling og kontroll av hypertensjon globalt? Går dødeligheten faktisk ned hvis man går 10 000 skritt om dagen? Hva med effekten av gode matvaner på dødelighet? Og hvor viktig er det med god økonomi? Hva er greia med den globale økningen i keisersnittfrekvens? Går det mot at aktiv dødshjelp blir tillatt i Storbritannia? Sjefredaktør Are Brean snakker om dette og mer i dagens episode.Tilbakemeldinger kan sendes til stetoskopet@tidsskriftet.no. Stetoskopet produseres av Irene Rønold, Are Brean og Julie Didriksen ved Tidsskrift for Den norske legeforening. Ansvarlig redaktør er Are Brean. Lydtekniker: Håkon Braaten / Moderne Media Coverillustrasjon: Stephen LeeArtikler nevnt:No revolution: COVID-19 boosted open access, but preprints are only a fraction of pandemic papersWorldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participantsSteps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults StudyEvaluation of Dietary Patterns and All-Cause MortalityAssociation of Wealth With Longevity in US Adults at MidlifeThe Pervasive Influence of Wealth Inequality on HealthAltering product placement to create a healthier layout in supermarkets: Outcomes on store sales, customer purchasing, and diet in a prospective matched controlled cluster studyChanges in maternal risk factors and their association with changes in cesarean sections in Norway between 1999 and 2016: A descriptive population-based registry studyAssisted dying: a question of when, not ifIt's time for all doctors to engage on assisted dyingDoctors' organisations, neutrality, and the assisted dying debateWill Scotland become the first part of the UK to legalise assisted dying?Assisted dying around the worldEuthanasia and assisted dying: the illusion of autonomy—an essay by Ole Hartling

  The Friday Five for September 10, 2021: Updates on Budget Reconciliation Bill Impact of Medicare Expansion How many steps per day? Hack to free up space in Gmail Apple announces California Streaming Register for your FREE RitterIM.com account   Mentioned in this episode:   Apple's iPhone 13 event will take place on September 14th Business groups aim to divide Democrats on $3.5T spending bill Democrats hit the gas on Biden's multitrillion-dollar safety net bill Experts say adding dental coverage to Medicare won't trigger major shift away from Medicare Advantage Forget 10,000 steps — here's how much you should actually walk per day, according to science GOP pressure to block bipartisan infrastructure bill builds in the House How to Mass Delete Emails in Gmail iPhone 13 release date: Here's everything we know about the announcement next week Pantone Fashion Color Trend Report: New York Fashion Week Spring/Summer 2022 Scoop: Manchin backs as little as $1 trillion of Biden's $3.5 trillion plan Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study Study Suggests a New Number of Daily Steps For Health Benefits, And It's Not 10,000   More episodes you'll like:   September 3, 2021 | The Friday Five How to Survive AEP 2022 Organization Tips and Tricks for AEP What Are the New Medicare Advantage & Part D Communication Requirements for 2022? Why Trust Is an Insurance Agent's Most Important Non-Renewable Resource   Articles to Share with Your Clients:   All About Medicare Waiting Periods Quick and Easy Recipes for One What is Sarcopenia?   Ritter Insurance Marketing eBooks & Guides:   Agent Survival Kits: Beginners or Experts A Quick Guide to Cross-Selling Ancillary Insurance with Medicare Products How to Host a Successful Medicare Educational Event   The latest from Ritter's Blog:   How to Prepare for AEP Like a Pro Ritter Acquires Executive Resource Insurance Network, Expands in Florida Why Trust Is an Insurance Agent's Most Important Non-Renewable Resource   Subscribe & Follow:   Apple Podcasts Google Podcasts Overcast Podbean Spotify Stitcher   Connect on social:   Facebook LinkedIn Twitter YouTube Instagram Sarah's LinkedIn Sarah's Instagram  

In this episode of Quah (Q & A), Sal, Adam & Justin answer Pump Head questions about the best way to increase grip strength, what it means to sweat a lot during a workout, the CNS effect of high reps with lower weight vs. low reps with higher weights, and the most effective way to bulk. 1636: The Mind Pump robot debate rages on. (4:48) Highlighting the massive mistake that scientists and government officials make when it comes to the obesity epidemic. (9:58) Mind Pump Recommends, Untold: Caitlyn Jenner on Netflix. (16:55) An interesting move by Bud Light. (25:05) Reliving all your worst childhood moments through your kids. (28:44) Busting the widespread myth that as you get older your mental capacity declines. (31:25) The Bishop Sycamore football controversy. (35:52) Is Jake Paul retiring from boxing?! (37:30) The ribs from Butcher Box are out of this world! (44:03) New product alert from Felix Gray! (45:39) #Quah question #1 – What is the best way to increase grip strength? (49:35) #Quah question #2 – Should I be concerned about my excessive sweating when working out? (56:47) #Quah question #3 – What is more taxing on the nervous system, high reps with lower weight or low reps with higher weight?(1:00:07) #Quah question #4 – What is the most effective way to bulk? Should I track or be intuitive? (1:04:20) Related Links/Products Mentioned September Promotion: MAPS Performance and MAPS Suspension 50% off!   **Promo code “SEPTEMBER50” at checkout** Reducing sugar in packaged foods can prevent disease in millions Untold: Caitlyn Jenner | Netflix Official Site Bud Light Releases Pumpkin Spice and Toasted Marshmallow Hard Seltzers Key Mental Abilities Can Actually Improve During Aging ESPN tricked into televising football game of 'fake' high school Bishop Sycamore Did Jake Paul just retire from boxing? Visit Butcher Box for this month's exclusive Mind Pump offer! Visit Felix Gray for an exclusive offer for Mind Pump listeners! Mind Pump Store Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies The ONLY Forearm Workout That Matters (TRY THIS!!) | MIND PUMP 5 Exercises For HUGE Forearms & A STRONGER Grip (FREE Big Arms Guide) How to Build a Strong Core with Kettlebell Farmers Walk – Mind Pump TV MAPS O.C.R. | Muscle Adaptation Programming System Intuitive Nutrition Guide | MAPS Fitness Products Mind Pump # 1427: Don't Make These 6 Bulking Mistakes  Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Joe De Sena (@realJoeDeSena) on Twitter Jake Paul (@jakepaul) on  Instagram

Prior research has established that the consumption of green tea or coffee has been said to reduce the all-cause mortality in the general public. However, as to the similar effects in those with health challenges, such as diabetes, research is either controversial or devoid – until now.Japanese researchers publishing the “Additive Effects of Green Tea and Coffee on All-Cause Mortality in Patients with Type-2 Diabetes Mellitus: the Fukuoka Diabetes Registry”, which appeared in October 2020 in the open-access online  BMJ (British Medical Journal) Diabetes Research & Care, determined that, “higher consumption of green tea and coffee was associated with reduced all-cause mortality: their combined effect appeared to be additive in patients with type-2 diabetes.”The Japanese researchers from the Departments of Medicine and Clinical Sciences, Graduate School of Medical Sciences and the Division of Internal Medicine, Fukuoka, Japan, comment that green tea derives benefits from fresh leaves of Camellia sinensis - containing various chemicals, such as phenolic compounds, theanine, and caffeine, which possess antioxidant, anti-inflammatory, or anti-bacterial properties. Coffee, note the Japanese, contains phenolic compounds and caffeine that offer antioxidant, anti-inflammatory, and ant-mutagenic benefits – especially, to type-2 diabetics, those with abnormal lipid profiles, and malignancy.To reach this conclusion, the investigators, after appropriate exclusion criteria, used data from 4923 study participants enrolled between April 2008 and October 2010, in the Fukuoka Diabetes Registry, “a multicenter prospective study designed to investigate the effects of modern treatments and lifestyle on the prognoses of patients with diabetes mellitus.”Using a self-administered questionnaire, the participants provided information regarding their diagnosed diabetes duration, smoking habits, alcohol intake, leisure-time physical activity, sleep duration, depressive symptoms, and history of coronary heart disease, stroke, and cancer. Their smoking habits and alcohol intake were classified as either current or not.  Body weight, height and body mass index were ascertained – along with blood pressure. Medical charts were reviewed for all medications, including insulin, oral hypoglycemic agent, antihypertensive drugs, antiplatelet drugs, and statins. The Japanese used self-reported answers to dietary questions to categorize the participants into the following four groups by beverage: green tea - none, ≤1 cup/day, 2–3 cups /day, ≥4 cups/day, and coffee - none,

In this episode Sal, Adam & Justin provide actionable ways to rekindle passion with working out. The challenge most fitness fanatics run into. (2:31) Why unconventional training can be a good thing. (5:01) The novelty is what is so special to the results. (8:13) What to Do When You Are Getting Bored with Your Workouts.  Step 1: Change your mindset. (11:52) Unconventional training techniques to change your mindset.  Work Capacity. (15:01)  Agility. (19:33) Body Weight Training. (22:05) Stability Training. (25:37) Grip Strength. (29:15) Improve Effective Range of Motion. (34:31) Forgotten Muscle-Building Exercises. (37:55) Step 2: Stay the course and properly program these modalities into your routine. (44:01) Step 3: Sign up for an unusual fitness event. (47:08) Related Links/Products Mentioned Special Promotion: MAPS Unconventional Bundle  Visit ZBiotics for an exclusive offer for Mind Pump listeners! Why You Need to Mix Rep Ranges After Periods of Training – Mind Pump Blog Mind Pump #1327: Five Mindset Techniques For Fitness Success How To Improve YOUR Work Capacity (6 MOVEMENTS) | MIND PUMP TV Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Exercises That You Probably Aren't Doing That You Should Be Doing For Maximum Muscle Gain – Mind Pump Blog Build Your Hamstrings- How to Properly do Good Mornings – Mind Pump TV Mind Pump #1330: Unconventional Training For Fat Loss And Muscle Gain Mind Pump #1315: The 8 Best Exercises You Are Not Doing Unconventional Weight Training Exercises that can Help you Pack on Muscle – Mind Pump Blog Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Robert Oberst (@robertoberst)  Instagram

Mary Ruddick is a seasoned medical nutritionist who specializes in metabolic, immune, and nervous system disorders. She is the Director of Nutrition for CaptainSoup.com, Enable Your Healing, The REIGNS Method, and the Back to Joy Program, and she currently travels the globe studying traditional diets and seeing patients online via her private practice.   Time Stamps:   0:11:16 Mary's Dream Penthouse 0:13:09 Mary on the hippo turf 0:16:13 The lion hunt (No lions were harmed in the making of this podcast) 0:20:46 How separated we've become. 0:26:39 Mary Ruddick's backstory 0:39:06 How Mary beat dysautonomia 0:47:54 What the Greeks actually eat (The blue zones are a myth) 0:54:38 Sociodemographic and Lifestyle Statistics of Oldest Old People (>80 Years) Living in Ikaria Island: The Ikaria Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051199/ 0:55:08 Determinants of All-Cause Mortality and Incidence of Cardiovascular Disease (2009 to 2013) in Older Adults: The Ikaria Study of the Blue Zones https://journals.sagepub.com/doi/10.1177/0003319715603185?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:55:41 Simplicity, purpose, and community: the recipe for a long life 1:00:07 Mary's African adventure and lots of carnivory 1:12:42 Mary eats a raw adrenal gland 1:17:09 The diet of the Shona 1:24:47 The power of traditional diets 1:28:29 Some insight into Mary's practice 1:33:12 [Vitamin K paper] 1:37:55 The role of animal foods in fertility 1:40:15 Mary's closing remarks 1:40:46 Where to find Mary Ruddick Heart & Soil: Heartandsoil.co for desiccated organ supplements  White Oak: Use “CarnivoreMD” at whiteoakpastures.com Belcampo: Use “CarnivoreMD” or “Carnivore10” at www.belcampo.com Helix: Helixsleep.com/carnivoremd for $200 off your mattress Blublox: Blublox.com, use “CarnivoreMD” for 15% off

FDA 批准RET选择性抑制剂治疗RET基因驱动的非小细胞肺癌JAMA 慢性阻塞性肺病患者出院后肺康复训练可以显著降低1年生存率Cell 超级抗生素的研制塞帕替尼（selpercatinib）RET基因融合是1%～2%非小细胞肺癌的致癌驱动基因，2020年5月，RET选择性抑制剂塞帕替尼（selpercatinib）同时被FDA批准用于治疗RET驱动的肺癌和甲状腺癌。本期节目首先介绍塞帕替尼在非小细胞肺癌中的临床研究，周五的内分泌科专题当中，会和大家讨论一下塞帕替尼在甲状腺癌中的应用。《LIBRETTO-001研究：塞帕替尼对RET融合阳性非小细胞肺癌的疗效的1/2临床研究》New England Journal of Medicine，2020年8月 (1)研究纳入接受过铂类化疗的和未接受过治疗的RET基因融合阳性的、晚期非小细胞肺癌患者共105例。中位随访12.1个月时，接受过铂类化疗的患者，客观缓解率64%；未接受过治疗的患者，客观缓解率85%；6个月时，90%的缓解仍持续。中枢神经系统转移的11例患者中，颅内缓解率91%。最常见严重不良事件包括高血压、谷丙转氨酶升高、谷草转氨酶升高、低钠血症和淋巴细胞减少，仅2%的患者因不良事件停药。结论：在RET融合阳性的、非小细胞肺癌患者中，塞帕替尼具有持久疗效。慢性阻塞性肺病 - 吸入剂治疗慢性阻塞性肺病（COPD）患者中使用吸入的支气管扩张剂，可以改善症状、运动能力。常用药物包括：快速起效的短效β受体激动剂吸入剂（SABA，如沙丁胺醇）；快速起效的长效β受体激动剂吸入剂（LABA，如沙美特罗、福莫特罗、阿福特罗、茚达特罗、维兰特罗、奥达特罗），长效抗毒蕈碱受体阻滞剂（LAMA，噻托嗅铵、阿地溴铵、芜地溴铵、格隆溴铵）；糖皮质激素吸入剂（ICS，布地奈德、倍氯米松、莫米松）。对于单用长效支气管扩张剂效果不好的患者，可以考虑联合方案，比如：LAMA联合LABA，LABA联合ICS。重症患者可以使用LAMA-LABA-ICS三联治疗。《IMPACT研究：使用氟替卡松/芜地溴铵/维兰特罗三联治疗方案降低COPD患者的全因死亡率》American Journal of Respiratory and Critical Medicine，2020年6月 (2)该研究纳入10355例、有未来恶化风险的COPD患者，随机给予ICS-LAMA-LABA三联吸入治疗方案（氟替卡松/芜地溴铵/维兰特罗），或者LAMA-LABA二联治疗方案（芜地溴铵/维兰特罗），或者ICS-LABA二联治疗方案（氟替卡松/维兰特罗）治疗。在三联治疗组和两个二联治疗组中，分别记录了2.36%、2.64%和3.19%的患者死亡。与二联治疗组相比，三联治疗组的患者死亡风险更低，风险比分别为0.72和0.89。结论：IMPACT研究证明，每日一次吸入氟替卡松/芜地溴铵/维兰特罗三联疗法，可以降低了有症状且有加重史的COPD患者的全因死亡率。《真实世界的队列研究：LAMA-LABA-ICS三联吸入方案和LAMA-LABA二联吸入方案对COPD的临床治疗比较效果》Chest，2020年4月 (3)研究者从英国临床实践研究数据链中确定了一组2002年至2015年间使用LAMA、LABA治疗方案或LAMA-LABA-ICS治疗方案的、≥55岁的、近2700例COPD患者，随访1年，观察中重度COPD加重和严重肺炎的发生情况。在COPD急性加重的发生率上来看，三联吸入疗法与LAMA-LABA二联疗法相比，风险比为0.97，没有统计学意义的降低。对于嗜酸性粒细胞计数>6%的患者，三联疗法可以显著降低COPD急性加重的风险，风险比0.66。对于反复因COPD急性加重住院的患者而言，三联疗法也可以显著降低COPD急性加重的风险，风险比0.83。但是在三联疗法组中，需要住院治疗的重症肺炎的发生率显著升高，风险比 1.46。结论：真实世界中，在预防COPD加重方面，LAMA-LABA-ICS三联吸入疗法与LAMA-LABA二联吸入疗法同样有效。但是在嗜酸性粒细胞增多、或频繁急性加重的患者中，三联治疗方案获益更多。除此之外，二联治疗方案可能更为可取，因为它与重症肺炎发生率较低相关。《系统综述和荟萃分析：布地奈德/格隆溴铵/福莫特罗三联吸入疗法和其他LAMA-LABA-ICS三联吸入疗法的疗效比较》Advances in Therapy，2020年6月 (4)这篇荟萃分析纳入了18项研究，29,232例患者的资料。在减轻中重度COPD患者病情加重、改善肺功能和症状方面，布地奈德/格隆溴铵/福莫特罗和其他三联吸入的固定剂量组合（氟替卡松/芜地溴铵/维兰特罗、倍氯米松/格隆溴铵/福莫特罗）没有统计学差异；和其他开放联合用药之间也没有统计学显著差异。敏感性分析和元回归分析的结果与基本情况一致。结论：在减轻中重度COPD患者病情加重、改善肺功能和症状方面，可布地奈德/格隆溴铵/福莫特罗与其他LAMA-LABA-ICS固定剂量三联疗法的疗效相似。小羽点评：从随机临床研究的角度看，固定剂量的三联吸入疗法在减少COPD患者病情加重方面的疗效是相似的，并且优于二联吸入疗法；然而，在真实世界中，三联吸入疗法的优势则不那么明显了，甚至还有可能增加重症肺炎的发生率。《IMPACT研究亚组分析：吸入糖皮质激素停用和基线吸入治疗对病情加重的影响》American Journal of Respiratory and Critical Care Medicine，2020年11月 (5)IMPACT研究证明，每日一次吸入氟替卡松/芜地溴铵/维兰特罗三联疗法，可以降低了有症状且有加重史的COPD患者的全因死亡率。这项亚组分析的目的是了解吸入糖皮质类固醇停药是否影响影响结果。与芜地溴铵/维兰特罗二联治疗方案相比，氟替卡松/芜地溴铵/维兰特罗三联治疗方案显著降低了以前使用糖皮质激素的患者中，COPD中重度急性的发生率显著降低29%（P < 0.001），但在先前不使用糖皮质激素的患者中这种获益并不显著（降低12%，P = 0.115）。无论先前是否使用过糖皮质激素，三联吸入治疗方案均可以降低重度急性发作达35%、持续改善第一秒用力呼气量谷值和圣乔治呼吸问卷评分（SGRQ）。结论：这些数据支持了三联治疗在减轻病情恶化、肺功能和生活质量方面的重要作用，而这些作用似乎与ICS的突然停用无关。《ISOLDE研究：吸入糖皮质激素治疗后血液嗜酸性粒细胞的变化可能预测慢性阻塞性肺病的长期临床反应》European Respiratory Journal，2020年5月 (6)此研究的目的是评价吸入糖皮质激素后，血液嗜酸性粒细胞的变化可以预测长期治疗结果。这项为期3年的双盲试验中，对751名中-重度COPD患者随机分入氟替卡松组和安慰剂组。研究发现，1年内的嗜酸性粒细胞的减少与治疗效果相关，而且是治疗反应的强预测因子。在嗜酸性粒细胞下降≥200/μL时，吸入糖皮质激素可降低第一秒用力呼气量（FEV1）下降率达32mL/年，恶化率降低30%。相反，在嗜酸性粒细胞升高≥200/μL时，吸入糖皮质激素可加速第一秒用力呼气量下降，下降速度为37mL/年，恶化率增加80% （P4年的患者患肺癌的风险比为0.92，无统计学意义。平均每日吸入糖皮质激素较高的患者肺癌的风险比为1.36（95% CI 1.03-1.81）。结论：在COPD患者中，吸入糖皮质激素与肺癌发病率的降低无关。《欧洲呼吸协会指南：慢性阻塞性肺病患者何时停用吸入糖皮质激素》European Respiratory Journal，2020年6月 (8)吸入糖皮质激素联合支气管扩张剂，可降低慢性阻塞性肺病患者病情加重的频率，但是糖皮质激素经常被用于疗效不确定的患者。因此文章建议对于下列情况停用吸入糖皮质激素：（1）若COPD患者没有频繁发作的病史，指南认为停用活继续糖皮质激素吸入治疗的获益风险比存在不确定性，需要充分告知和与患者讨论；（2）若血液嗜酸性粒细胞计数≥300/µl，指南强烈建议不要停用吸入糖皮质激素；（3）若准备停用吸入糖皮质激素，指南强烈建议使用一个或两个长效支气管扩张剂。COPD患者肺康复训练肺康复可以改善慢性呼吸系统疾病患者的症状、生存质量和肺功能。肺康复包括运动训练、促进将康的行为（比如戒烟、锻炼、营养支持、恰当用药和自我管理）和心理支持。运动训练可以采用下肢训练（如，固定式脚踏车、跑步机或自由行走）、上肢训练（如手臂训练）、间歇运动训练、抗阻力/力量训练和呼吸再训练。《回顾性队列研究：COPD出院后开始肺康复1年生存率的影响》JAMA，2020年5月 (9)肺康复训练与慢性阻塞性肺病患者生存率提高相关，但相关研究的患者数量少且异质性高。研究的目的时确定慢性阻塞性肺病患者出院后90天内开始肺部康复与1年生存率之间的关系。研究纳入197 376例患者、平均年龄76.9岁，1.5%的患者在出院后90天内开始肺康复。出院1年内死亡率19.4%，其中进行肺康复训练者死亡率7.3%，没有进行康复训练者死亡率19.6%。进行肺康复训练者绝对死亡风险下降6.7%，风险比 0.63。结论：慢性阻塞性肺病病人，出院后3个月内开始肺部康复1年死亡率显著降低。《随机对照研究：下坡行走对COPD患者肺部康复的影响》European Respiratory Journal，2020年5月 (10)收缩性肌肉疲劳影响COPD患者的训练反应。下坡步行诱发收缩肌疲劳、呼吸困难和疲劳程度较平地步行低。本研究比较了下坡步行训练和平地步行训练的方式进行肺康复对COPD患者的影响。在这项随机对照试验中，35例患者，平均年龄62岁，第一秒最大呼气量（FEV1）平均50%，随机分为下坡步行组或平地步行组。两组间，6分钟步行试验结果和肌肉活检没有差异（p=0.45）；但是94%的进行下坡行走锻炼的患者进步了，平地行走组仅为65%（p=0.03）。在其他方面，下坡行走组也有更大的改善。结论：在慢性阻塞性肺病患者中，结合下坡行走与常规步行在肺康复临床疗效上具有相似的效果；但是锻炼耐受性更好。《ON-EPIC研究：口服硝酸盐补充剂增强慢性阻塞性肺病肺部康复》Thorax 2020年7月 (11)研究的目的是评估口服硝酸盐是否能增强慢性阻塞性肺病患者的肺康复效果。这项双盲、安慰剂对照、平行组、随机对照研究在四个英国中心进行，登记了患有GOLD分级II-IV级的、医学研究委员会（Medical Research Council）呼吸困难评分3-5分或功能受限的COPD成年患者，进行每周两次、为期8周的肺康复训练计划。他们被随机分配到140ml富含硝酸盐的甜菜汁组（含12.9 mmol硝酸盐），或安慰剂组，服用前3小时进行肺康复训练治疗。积极治疗组(57例)的运动能力比安慰剂组(65例)提高更多;ISWT距离+60 m (10,85) vs +30 m(0,70)中值(IQR)变化，估计处理效果30 m (95% CI 10 ~ 40);p = 0.027。积极治疗对收缩压也有影响:治疗组-5.0 mm Hg (-5.0， -3.0) vs对照组+6.0 mm Hg(-1.0, 15.5)，估计治疗效果-7 mm Hg (95% CI 7 ~ -20) (p

FDA 批准RET选择性抑制剂治疗RET基因驱动的非小细胞肺癌JAMA 慢性阻塞性肺病患者出院后肺康复训练可以显著降低1年生存率Cell 超级抗生素的研制塞帕替尼（selpercatinib）RET基因融合是1%～2%非小细胞肺癌的致癌驱动基因，2020年5月，RET选择性抑制剂塞帕替尼（selpercatinib）同时被FDA批准用于治疗RET驱动的肺癌和甲状腺癌。本期节目首先介绍塞帕替尼在非小细胞肺癌中的临床研究，周五的内分泌科专题当中，会和大家讨论一下塞帕替尼在甲状腺癌中的应用。《LIBRETTO-001研究：塞帕替尼对RET融合阳性非小细胞肺癌的疗效的1/2临床研究》New England Journal of Medicine，2020年8月 (1)研究纳入接受过铂类化疗的和未接受过治疗的RET基因融合阳性的、晚期非小细胞肺癌患者共105例。中位随访12.1个月时，接受过铂类化疗的患者，客观缓解率64%；未接受过治疗的患者，客观缓解率85%；6个月时，90%的缓解仍持续。中枢神经系统转移的11例患者中，颅内缓解率91%。最常见严重不良事件包括高血压、谷丙转氨酶升高、谷草转氨酶升高、低钠血症和淋巴细胞减少，仅2%的患者因不良事件停药。结论：在RET融合阳性的、非小细胞肺癌患者中，塞帕替尼具有持久疗效。慢性阻塞性肺病 - 吸入剂治疗慢性阻塞性肺病（COPD）患者中使用吸入的支气管扩张剂，可以改善症状、运动能力。常用药物包括：快速起效的短效β受体激动剂吸入剂（SABA，如沙丁胺醇）；快速起效的长效β受体激动剂吸入剂（LABA，如沙美特罗、福莫特罗、阿福特罗、茚达特罗、维兰特罗、奥达特罗），长效抗毒蕈碱受体阻滞剂（LAMA，噻托嗅铵、阿地溴铵、芜地溴铵、格隆溴铵）；糖皮质激素吸入剂（ICS，布地奈德、倍氯米松、莫米松）。对于单用长效支气管扩张剂效果不好的患者，可以考虑联合方案，比如：LAMA联合LABA，LABA联合ICS。重症患者可以使用LAMA-LABA-ICS三联治疗。《IMPACT研究：使用氟替卡松/芜地溴铵/维兰特罗三联治疗方案降低COPD患者的全因死亡率》American Journal of Respiratory and Critical Medicine，2020年6月 (2)该研究纳入10355例、有未来恶化风险的COPD患者，随机给予ICS-LAMA-LABA三联吸入治疗方案（氟替卡松/芜地溴铵/维兰特罗），或者LAMA-LABA二联治疗方案（芜地溴铵/维兰特罗），或者ICS-LABA二联治疗方案（氟替卡松/维兰特罗）治疗。在三联治疗组和两个二联治疗组中，分别记录了2.36%、2.64%和3.19%的患者死亡。与二联治疗组相比，三联治疗组的患者死亡风险更低，风险比分别为0.72和0.89。结论：IMPACT研究证明，每日一次吸入氟替卡松/芜地溴铵/维兰特罗三联疗法，可以降低了有症状且有加重史的COPD患者的全因死亡率。《真实世界的队列研究：LAMA-LABA-ICS三联吸入方案和LAMA-LABA二联吸入方案对COPD的临床治疗比较效果》Chest，2020年4月 (3)研究者从英国临床实践研究数据链中确定了一组2002年至2015年间使用LAMA、LABA治疗方案或LAMA-LABA-ICS治疗方案的、≥55岁的、近2700例COPD患者，随访1年，观察中重度COPD加重和严重肺炎的发生情况。在COPD急性加重的发生率上来看，三联吸入疗法与LAMA-LABA二联疗法相比，风险比为0.97，没有统计学意义的降低。对于嗜酸性粒细胞计数>6%的患者，三联疗法可以显著降低COPD急性加重的风险，风险比0.66。对于反复因COPD急性加重住院的患者而言，三联疗法也可以显著降低COPD急性加重的风险，风险比0.83。但是在三联疗法组中，需要住院治疗的重症肺炎的发生率显著升高，风险比 1.46。结论：真实世界中，在预防COPD加重方面，LAMA-LABA-ICS三联吸入疗法与LAMA-LABA二联吸入疗法同样有效。但是在嗜酸性粒细胞增多、或频繁急性加重的患者中，三联治疗方案获益更多。除此之外，二联治疗方案可能更为可取，因为它与重症肺炎发生率较低相关。《系统综述和荟萃分析：布地奈德/格隆溴铵/福莫特罗三联吸入疗法和其他LAMA-LABA-ICS三联吸入疗法的疗效比较》Advances in Therapy，2020年6月 (4)这篇荟萃分析纳入了18项研究，29,232例患者的资料。在减轻中重度COPD患者病情加重、改善肺功能和症状方面，布地奈德/格隆溴铵/福莫特罗和其他三联吸入的固定剂量组合（氟替卡松/芜地溴铵/维兰特罗、倍氯米松/格隆溴铵/福莫特罗）没有统计学差异；和其他开放联合用药之间也没有统计学显著差异。敏感性分析和元回归分析的结果与基本情况一致。结论：在减轻中重度COPD患者病情加重、改善肺功能和症状方面，可布地奈德/格隆溴铵/福莫特罗与其他LAMA-LABA-ICS固定剂量三联疗法的疗效相似。小羽点评：从随机临床研究的角度看，固定剂量的三联吸入疗法在减少COPD患者病情加重方面的疗效是相似的，并且优于二联吸入疗法；然而，在真实世界中，三联吸入疗法的优势则不那么明显了，甚至还有可能增加重症肺炎的发生率。《IMPACT研究亚组分析：吸入糖皮质激素停用和基线吸入治疗对病情加重的影响》American Journal of Respiratory and Critical Care Medicine，2020年11月 (5)IMPACT研究证明，每日一次吸入氟替卡松/芜地溴铵/维兰特罗三联疗法，可以降低了有症状且有加重史的COPD患者的全因死亡率。这项亚组分析的目的是了解吸入糖皮质类固醇停药是否影响影响结果。与芜地溴铵/维兰特罗二联治疗方案相比，氟替卡松/芜地溴铵/维兰特罗三联治疗方案显著降低了以前使用糖皮质激素的患者中，COPD中重度急性的发生率显著降低29%（P < 0.001），但在先前不使用糖皮质激素的患者中这种获益并不显著（降低12%，P = 0.115）。无论先前是否使用过糖皮质激素，三联吸入治疗方案均可以降低重度急性发作达35%、持续改善第一秒用力呼气量谷值和圣乔治呼吸问卷评分（SGRQ）。结论：这些数据支持了三联治疗在减轻病情恶化、肺功能和生活质量方面的重要作用，而这些作用似乎与ICS的突然停用无关。《ISOLDE研究：吸入糖皮质激素治疗后血液嗜酸性粒细胞的变化可能预测慢性阻塞性肺病的长期临床反应》European Respiratory Journal，2020年5月 (6)此研究的目的是评价吸入糖皮质激素后，血液嗜酸性粒细胞的变化可以预测长期治疗结果。这项为期3年的双盲试验中，对751名中-重度COPD患者随机分入氟替卡松组和安慰剂组。研究发现，1年内的嗜酸性粒细胞的减少与治疗效果相关，而且是治疗反应的强预测因子。在嗜酸性粒细胞下降≥200/μL时，吸入糖皮质激素可降低第一秒用力呼气量（FEV1）下降率达32mL/年，恶化率降低30%。相反，在嗜酸性粒细胞升高≥200/μL时，吸入糖皮质激素可加速第一秒用力呼气量下降，下降速度为37mL/年，恶化率增加80% （P4年的患者患肺癌的风险比为0.92，无统计学意义。平均每日吸入糖皮质激素较高的患者肺癌的风险比为1.36（95% CI 1.03-1.81）。结论：在COPD患者中，吸入糖皮质激素与肺癌发病率的降低无关。《欧洲呼吸协会指南：慢性阻塞性肺病患者何时停用吸入糖皮质激素》European Respiratory Journal，2020年6月 (8)吸入糖皮质激素联合支气管扩张剂，可降低慢性阻塞性肺病患者病情加重的频率，但是糖皮质激素经常被用于疗效不确定的患者。因此文章建议对于下列情况停用吸入糖皮质激素：（1）若COPD患者没有频繁发作的病史，指南认为停用活继续糖皮质激素吸入治疗的获益风险比存在不确定性，需要充分告知和与患者讨论；（2）若血液嗜酸性粒细胞计数≥300/µl，指南强烈建议不要停用吸入糖皮质激素；（3）若准备停用吸入糖皮质激素，指南强烈建议使用一个或两个长效支气管扩张剂。COPD患者肺康复训练肺康复可以改善慢性呼吸系统疾病患者的症状、生存质量和肺功能。肺康复包括运动训练、促进将康的行为（比如戒烟、锻炼、营养支持、恰当用药和自我管理）和心理支持。运动训练可以采用下肢训练（如，固定式脚踏车、跑步机或自由行走）、上肢训练（如手臂训练）、间歇运动训练、抗阻力/力量训练和呼吸再训练。《回顾性队列研究：COPD出院后开始肺康复1年生存率的影响》JAMA，2020年5月 (9)肺康复训练与慢性阻塞性肺病患者生存率提高相关，但相关研究的患者数量少且异质性高。研究的目的时确定慢性阻塞性肺病患者出院后90天内开始肺部康复与1年生存率之间的关系。研究纳入197 376例患者、平均年龄76.9岁，1.5%的患者在出院后90天内开始肺康复。出院1年内死亡率19.4%，其中进行肺康复训练者死亡率7.3%，没有进行康复训练者死亡率19.6%。进行肺康复训练者绝对死亡风险下降6.7%，风险比 0.63。结论：慢性阻塞性肺病病人，出院后3个月内开始肺部康复1年死亡率显著降低。《随机对照研究：下坡行走对COPD患者肺部康复的影响》European Respiratory Journal，2020年5月 (10)收缩性肌肉疲劳影响COPD患者的训练反应。下坡步行诱发收缩肌疲劳、呼吸困难和疲劳程度较平地步行低。本研究比较了下坡步行训练和平地步行训练的方式进行肺康复对COPD患者的影响。在这项随机对照试验中，35例患者，平均年龄62岁，第一秒最大呼气量（FEV1）平均50%，随机分为下坡步行组或平地步行组。两组间，6分钟步行试验结果和肌肉活检没有差异（p=0.45）；但是94%的进行下坡行走锻炼的患者进步了，平地行走组仅为65%（p=0.03）。在其他方面，下坡行走组也有更大的改善。结论：在慢性阻塞性肺病患者中，结合下坡行走与常规步行在肺康复临床疗效上具有相似的效果；但是锻炼耐受性更好。《ON-EPIC研究：口服硝酸盐补充剂增强慢性阻塞性肺病肺部康复》Thorax 2020年7月 (11)研究的目的是评估口服硝酸盐是否能增强慢性阻塞性肺病患者的肺康复效果。这项双盲、安慰剂对照、平行组、随机对照研究在四个英国中心进行，登记了患有GOLD分级II-IV级的、医学研究委员会（Medical Research Council）呼吸困难评分3-5分或功能受限的COPD成年患者，进行每周两次、为期8周的肺康复训练计划。他们被随机分配到140ml富含硝酸盐的甜菜汁组（含12.9 mmol硝酸盐），或安慰剂组，服用前3小时进行肺康复训练治疗。积极治疗组(57例)的运动能力比安慰剂组(65例)提高更多;ISWT距离+60 m (10,85) vs +30 m(0,70)中值(IQR)变化，估计处理效果30 m (95% CI 10 ~ 40);p = 0.027。积极治疗对收缩压也有影响:治疗组-5.0 mm Hg (-5.0， -3.0) vs对照组+6.0 mm Hg(-1.0, 15.5)，估计治疗效果-7 mm Hg (95% CI 7 ~ -20) (p

Not one to shy away from controversy, Dr. Tommy Wood has worked with some of the highest performing athletes in the world. From Formula One to Ironmans, what are some of the key takeaways Tommy had on behavior change from that experience? You would be surprised at how little free time these people have. I also get the chance to pick Tommy's brain on the problems with nutritional epidemiology, genetics, and how to evaluate nascent supplements and compounds where little research may exist. Who is Tommy Wood? Tommy Wood is a Research Assistant Professor of Pediatrics in the University of Washington Division of Neonatology. The majority of his academic work has focused on developing therapies for brain injury in newborn infants, but also includes adult neurodegenerative and metabolic diseases, as well as nutritional approaches to sports performance.Tommy received an undergraduate degree in biochemistry from the University of Cambridge before obtaining his medical degree from the University of Oxford. After working as a doctor in central London, he moved to Norway for his PhD work, and then to the University of Washington as a postdoc. Alongside his academic training, Tommy has coached athletes in a dozen sports, from weekend warriors to Olympians and world champions. He is the outgoing President of the Physicians for Ancestral Health society, a director of the British Society of Lifestyle Medicine, and sits on the scientific advisory board of Hintsa Performance, which includes researching performance optimization strategies for F1 drivers.Tommy’s current research interests include the physiological and metabolic responses to brain injury and their long-term effects on brain health, as well as developing easily-accessible methods with which to track human health, performance, and longevity. He and his wife Elizabeth share their home with two energetic (and goofy) boxers, and in his spare time, Tommy can usually be found cooking, hiking, reading, or lifting something heavy. Highlights[7:21] Bad science and nutritional epidemiology[12:03] Are direct to consumer genetic tests a joke?[32:05] How can we improve the research on cannabis?[40:10] Behavior change in Formula One drivers[47:55] Sacrificing longevity for short term performance[51:30] Traumatic brain injury[1:00:08] Is there hope for exogenous ketones? ResourcesCHEMEX CoffeemakerAeroPress Coffee and Espresso MakerHigh Protein Intake Is Associated with Lower Risk of All-Cause Mortality in Community23andmeWhen Brains Collide by Michael LewisBehave by Robert SapolskySponsorsBLUblox What brands of blue light blockers do I recommend? BluBlox is definitely a go-to. The CEO Andy Mant on the show before where we got into a really deep dive on blue light. If you get any amount of blue light in your glasses, no matter if it’s 3%, 10%, it disrupts melatonin production. So Andy has created blue light blockers that hold up to the highest standards. And in fact, you can see he’s tested it versus other brands and that they always come out on top.Quality matters. If you head over to blublox.com and plug in the code “DS15”, you’re going to get 15% off your order.TroscriptionsOne of my favorite tools for cognitive enhancement, especially after long plan rides, is Blue Cannatine. The delivery mechanism is unique (buccle troche). It is especially effective for me on improving short-term memory, focus, and verbal fluency.It’s the closest thing that I found to NZT and I think you guys should try it out. Get yours at troscriptions.com. Plug in the code BOOMER for 10% OFF your “Limitless” experience.Full disclosure: I am involved with the company (I like the product that much).Continue Your High Performance Journey with Dr. Tommy WoodWebsite https://www.drragnar.com/Twitter https://twitter.com/drragnarInstagram https://www.instagram.com/drtommywood/Disclaimer This information is being provided to you for educational and informational purposes only. This is being provided as a self-help tool to help you understand your genetics, biodata and other information to enhance your performance. It is not medical or psychological advice. Virtuosity LLC, or Decoding Superhuman, is not a doctor. Virtuosity LLC is not treating, preventing, healing, or diagnosing disease. This information is to be used at your own risk based on your own judgment. For the full Disclaimer, please go to (Decodingsuperhuman.com/disclaimer). See acast.com/privacy for privacy and opt-out information.

INGREDIENTS OF THE DAY:  None There is increasing, although indirect evidence, that the American diet is linked to the severity of the pandemic in the United States.  So, with some reservations, given that this topic ranges far afield from my area of expertise, I will attempt to connect the dots between catching the virus and suffering from its complications by looking at the immune system, pre-existing conditions, the standard American diet, and ultra-processed foods.  This will be a challenge, but let’s go for it. Show Notes: To Contact Show:  foodlabelsrevealed@gmail.com Facebook Page:  https://www.facebook.com/prophetofprocessedfood/?ref=bookmarks The podcast can be subscribed to at the iTunes store, or Google Play, or using most of the podcast apps available for smart phones or tablets.  Just search under Food Labels Revealed. References: Daily Mail, “Revealed, the Reason Why Obese People May Be More at Risk of Coronavirus” https://tinyurl.com/y4t5jeu3 CNN, “How to Strengthen Your Immunity During the Coronavirus Pandemic” https://tinyurl.com/tugpkbr Science Direct, “The Impact of Nutrition on COVID-19” https://tinyurl.com/yybxftd3 Nutrients Journal, “COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation” https://tinyurl.com/ycbh7773 CDC, “Obesity and COVID-19” https://tinyurl.com/y5wodxbj PCRM, “Diet Can Fight Diseases Linked to Poor COVID-19 Outcomes” https://tinyurl.com/y5xs6wgh Web MD, “Coronavirus and High Blood Pressure: What’s the Link?” https://tinyurl.com/y4g89uhk CDC, “Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019” https://tinyurl.com/sowj9zs CDC, “The Difference Between Flu and COVID-19​” https://tinyurl.com/y2f25nje British Medical Journal, “Association Between Consumption of Ultra-processed Foods and All Cause Mortality” https://tinyurl.com/y45v436k Music: Intro music is the "Peter Gunn Theme" by Henri Mancini Outro music is “Comfortable Mystery 3” courtesy of Kevin McLeod.

In this episode, Sal, Adam & Justin discuss five important steps that anyone can take to improve their odds of living to 100. How we perceive and value our health matters! (3:02) Living day to day is not living, it's surviving. (9:10) Five Steps to Living Well and Living Long. (15:03) #1 – To be strong. (16:24) #2 – Do NOT overeat and AVOID heavily processed foods. (26:05) #3 – Having good relationships. (36:36) #4 – Having a regular spiritual practice. (43:32) #5 – Incorporating a movement practice. (49:45) Related Links/Products Mentioned August Promotion: MAPS Performance ½ off!! **Promo code “GREEN50” at checkout** Visit Legion Athletics for the exclusive offer for Mind Pump listeners! **Code “mindpump” at checkout** Powder Mountain - Community Welcome to Powder Mountain – a utopian club for the millennial elite Lifestyle gets blame for 70% to 90% of all cancers Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Diseases, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies Exercise for Your Bone Health 5 Long-Term Benefits of Resistance Training – Mind Pump Blog NIH study finds heavily processed foods cause overeating and weight gain The health benefits of strong relationships People with Religious Affiliations Live Longer, Study Shows Mind Pump #1050: Mark Manson- The Subtle Art Of Not Giving A F*Ck Why Fast Walkers May Live 15–20 Years Longer Than the Rest of Us Mind Pump Podcast - YouTube Mind Pump Free Resources People Mentioned Mark Manson (@markmanson)  Instagram

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792273/ Does Rewording MRI Reports Improve Patient Understanding and Emotional Response to a Clinical Report? Remember few weeks ago when I talked about 50% of people knew that broken bone and fracture were the same thing or that 1 in 5 pts couldn’t describe nonweight baring? Well this study looked o see what would happen if we changed the language in MRI reports 100pts- list of all shoulder, elbow, wrist, and hand MR images ordered in 2011 was obtained from the radiology service-- The original reports were reworded to the recommended reading level for effective health education below the eighth-grade level words such as “tear” were replaced by more descriptive and accurate words such as hole, signal change, or defect. They also used analogies (eg, gray hair, bald spot) looked at bunch of outcomes but thing I care about was understanding—did the pt understand it and they used a 10 point scale- basically asked th pts. On 1-10 scale how did you understand that report- The understanding score (mean ± SD) of all the original reports was lower (4.2 ± 2.3) compared with the reworded report (8.1 ± 2.6, p < 0.001) https://www.bmj.com/content/368/bmj.m7 Objective To assess whether an association exists between financial links to the indoor tanning industry and conclusions of indoor tanning literature. Results 691 articles were included in analysis, including empiric articles (eg, original articles or systematic reviews) (357/691; 51.7%) and non-empiric articles letters (eg, commentaries, letters, or editorials) (334/691; 48.3%). Overall, 7.2% (50/691) of articles had financial links to the indoor tanning industry; 10.7% (74/691) articles favored indoor tanning, 3.9% (27/691) were neutral, and 85.4% (590/691) were critical of indoor tanning. Among the articles without industry funding, 4.4% (27/620) favored indoor tanning, 3.5% (22/620) were neutral, and 92.1% (571/620) were critical of indoor tanning. Among the articles with financial links to the indoor tanning industry, 78% (39/50) favored indoor tanning, 10% (5/50) were neutral, and 12% (6/50) were critical of indoor tanning. Support from the indoor tanning industry was significantly associated with favoring indoor tanning (risk ratio 14.3, 95% confidence interval 10.0 to 20.4). Listen to an interview with authors that basically point out the tanning industry is doing what the smoking industry was doing for years- trying to hide and bury and throw money at it https://www.fda.gov/news-events/press-announcements/fda-approves-first-generic-proair-hfa generic pro-air—problem is the drug and the delivery system! give credit to the FDA Under the Generic Drug User Fee Amendments (GDUFA), individual companies can meet with the FDA as part of its pre-Abbreviated New Drug Application (ANDA) program to support the development of such complex generic drug products. The FDA also publishes guidance documents describing the steps the FDA recommends companies take to submit complete applications for generic drug products. In 2016, the FDA issued a revised draft product-specific guidance for proposed generic albuterol. the draft guidance provides bioequivalence recommendations. And the article that has me the most stumped is this article titled https://www.ncbi.nlm.nih.gov/pubmed/31976865 You see most of the time randomized trials of anticoagulation for atrial fibrillation exclude hemodialysis patients. However this analysis of observational studies including almost 72,000 dialysis patients sought to seek the risk and benefits of anticoagulation for those individuals with atrial fibrillation on dialysis. To me this would be no-brainer. Patient has a fibrillation makes you more prominent clot dialysis makes you more prone to clotting. Easily getting anticoagulation has to improve the rates of thrombotic events. However of the 16 studies only abixan 5 mg was associated with lower ALL CAUSE MORTALITY. Compared with placebo or no anticoagulation -warfarin and apixaban were not associated with fever embolic events. Warfarin was associated with higher risk for major bleeding then no anticoagulation https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2766471 Effectiveness of Adenotonsillectomy vs Watchful Waiting in Young Children With Mild to Moderate Obstructive Sleep ApneaA Randomized Clinical Trial Look to find if ‘Is adenotonsillectomy (ATE) more effective than watchful waiting for treating otherwise healthy children, between 2 and 4 years of age, with mild to moderate obstructive sleep apnea (OSA)?' A total of 60 children, 2 to 4 years of age, with an obstructive apnea–hypopnea index (OAHI) score of 2 or greater and less than 10, were randomized to Adenotonsillectomy ATE (n = 29) or watchful waiting (n = 31). The primary outcome was the difference between the groups in mean obstructive apnea–hypopnea index OAHI score change THE SAY “Both groups had a decrease in mean obstructive apnea–hypopnea index OAHI score, and the difference in mean obstructive apnea–hypopnea index OAHI score change between the groups was small (−1.0; 95% CI, −2.4 to 0.5), in favor of AdenotonsillectomyATE” A difference of 2 in obstructive apnea–hypopnea indexOAHI score change was used as a minimally clinically important difference between the groups, with a standard deviation of 2.5. The AdenotonsillectomyATE group had a mean obstructive apnea–hypopnea index OAHI score decrease of −2.9 (95% CI, −4.0 to −1.9; Cohen d = −1.14), the watchful waiting group had a mean decrease of −1.9 (95% CI, −3.0 to −0.9; Cohen d = −0.71), and the difference between the groups in mean change was small, −1.0 (95% CI, −2.4 to 0.5; Cohen d = −0.37) “Both groups had a decrease in mean obstructive apnea–hypopnea index OAHI score, and the difference in mean obstructive apnea–hypopnea index OAHI score change between the groups was small (−1.0; 95% CI, −2.4 to 0.5), in favor of ATE” – which is interesting because it didn’t reach stastical signifance or your end point so why you would say smal but favor of ATE was my first red flag and then The authors go on to say there were large differences between the groups in favor of ATE regarding the Obstructive Sleep Apnea–18 (OSA–18) questionnaire, OSA–18 questionnaire (eg, total OSA–18 score: −17; 95% CI, −24 to −10). basically saying when questioned those that got surgery were happier-- those that had an invasive surgery FELT like they were doing better but we know that that there was no difference in those individuals again not blinded THIS IS THE PROBLEM- blinding the pt. prevents you from bias prior to randomization and during the study.. blinding the provider prevents you from bias during and after randomization

As we age, especially over 65, our habitual sleep duration changes— emphasizing a potentially shorter duration that has been associated with increased risk to obesity and hypertension— irrespective of sleep apnea (stop breathing) interruptions.According to Association of Longitudinal Patterns of Habitual Sleep Duration with Risk of Cardiovascular Events and All-Cause Mortality, which appeared on JAMA Network Open in April of 2020, “a laboratory study suggested that a repeating pattern of insufficient sleep may lead to long-term metabolic changes that cannot be effectively mitigated by weekend recovery sleep.”These findings, comment the Chinese study authors, “highlight the importance of examining the effect of long-term patterns of sleep duration beyond single or mean measures, which fail to consider the effect of change in sleep duration over time.”Chinese researchers sought to look at the direction of long-term versus single-measure sleep duration’s effect on cardiovascular events (CVE’s) and all-cause mortality - by using the Kailuan study population of 52,599 Chinese adults without atrial fibrillation, myocardial infarction, stroke, or cancer - between 2006 to 2010 - with risk of CVEs and all-cause mortality from January 1, 2010, to December 31, 2017.Study participants completed a face-to-face questionnaire survey, which highlighted demographic characteristics, medical comorbidity, medical history, medication use, and lifestyle factors - including measures of sleep, clinical examinations, and laboratory tests. Participants were then followed up biennially to update the data— with outcome events recorded annually until death or December 31, 2017, whichever came first.The study data suggested that, “trajectories in sleep duration were significantly associated with the risk of the first CVE’s and death, even after adjustment for a single measure of baseline sleep duration.” The authors note that conventional evidence supports that, “single measures of sleep duration were associated with adverse health outcomes.”Relative to the effects of short-term versus long-term sleep duration, “participants with short (less than 6 hours per night) and long (8 to less than 9 hours per night) sleep duration had adverse health outcomes, regardless of their earlier sleep patterns,” which led to the findings that, “trajectories of long-term sleep duration are associated with subsequent risk of CVE’s and death besides one-off measures closer to the time of events.”The Chinese researchers said that, “the better understanding of the effect and timing of change in sleep duration may help to identify populations with higher risk, who can then be targeted with interventions to promote cardiovascular health and healthy sleep.”In conclusion, “sleep duration trajectories with lower or unstable patterns were significantly associated with increased risk of subsequent first CVEs and all-cause mortality.” As was noted, much more research is needed to determine the appropriate quality and quantity of sleep, including napping, to add to our menu of healthy living criteria.

Reference: 1.Lupton JR, Brooks J, Butte N, Caballero B, Flatt J, Fried S. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. National Academy Press: Washington, DC, USA. 2002;5:589-768. 2.Janpaeng J, Santivarangkna C, Suttisansanee U, Emsawasd V, editors. Effect of probiotic fermentation on bioactivity in fermented soy milk. The International Conference on Food and Applied Bioscience proceeding book; 2018: Agro-Industry, Chiang Mai University Thailand. 3.Turner ND, Lupton JR. Dietary Fiber. Advances in Nutrition. 2011;2(2):151-2. 4.McDougall J. Plant foods have a complete amino acid composition. Circulation. 2002;105(25):e197. 5.Eating more plant protein and dairy instead of red meat may improve heart health. American Heart Association EPI | LIFESTYLE 2020 Scientific Sessions. Available at: https://newsroom.heart.org/news/eating-more-plant-protein-and-dairy-instead-of-red-meat-may-improve-heart-health [Accessed 5 May 2020]. 6.Kim H, Caulfield LE, Garcia‐Larsen V, Steffen LM, Coresh J, Rebholz CM. Plant‐Based Diets Are Associated With a Lower Risk of Incident Cardiovascular Disease, Cardiovascular Disease Mortality, and All‐Cause Mortality in a General Population of Middle‐Aged Adults. Journal of the American Heart Association. 2019;8(16):e012865. 7.Q&A on the carcinogenicity of the consumption of red meat and processed meat. (2015). World Health Organization: WHO. Available at: http://www.who.int/features/qa/cancer-red-meat/en/ [Accessed 7 May. 2020] 8.Processed meats do cause cancer - WHO. (2015). [ebook] Health editor, BBC News website. Available at: https://www.bbc.com/news/health-34615621 [Accessed 7 May. 2020]. 9.IARC Monographs evaluate consumption of red meat and processed meat. (2015). International Agency for Research on Cancer: IARC. Available at: http://www.iarc.fr/en/media- centre/pr/2015/pdfs/pr240_E.pdf [Accessed 7 May. 2020]. 10.Known and Probable Human Carcinogens. (2016). The American Cancer Society. Available at: https://www.cancer.org/cancer/cancer-causes/general-info/known-and-probable-human-carcinogens.html [Accessed 7 May. 2020]. 11.Plutonium radioactive. (2006). National Library of Medicine, National Institutes of Health. Available at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6465 [Accessed 7 May. 2020]. 12.สารหนูและแคดเมียม ในอาหารทะเล…ปลอดภัยต่อการบริโภคหรือไม่?. นุชนาถ รังคดิลก, สุมลธา หนูคาบแก้วและจุฑามาศ สัตยวิวัฒน์. (2015). http://www.eht.sc.mahidol.ac.th/article/1657 [Accessed 7 May. 2020]. 13.Marsh KA, Munn EA, Baines SK. Protein and vegetarian diets. Med J Aust. 2013;199(4 Suppl):S7-S10. 14.Rice, brown, with beans. (2020). U.S. DEPARTMENT OF AGRICULTURE Agricultural Research Service. Available at: https://fdc.nal.usda.gov/fdc-app.html#/food-details/786365/nutrients [Accessed 7 May. 2020]. 15.Ruairi Robertson. (2017). The 9 Healthiest Beans and Legumes You Can Eat. Available at: https://www.healthline.com/nutrition/healthiest-beans-legumes [Accessed 7 May. 2020]. 16.Rizzo G, Baroni L. Soy, soy foods and their role in vegetarian diets. Nutrients. 2018;10(1):43. 17.Han KK, Soares Jr JM, Haidar MA, De Lima GR, Baracat EC. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstetrics & Gynecology. 2002;99(3):389-94. 18.Seaweed, spirulina, dried. 19.Chia Seeds. (2019). U.S. DEPARTMENT OF AGRICULTURE Agricultural Research Service. Available at: https://fdc.nal.usda.gov/fdc-app.html#/food-details/578073/nutrients [Accessed 7 May. 2020]. 20.Hemp Seed. (2019). U.S. DEPARTMENT OF AGRICULTURE Agricultural Research Service. Available at: https://fdc.nal.usda.gov/fdc-app.html#/food-details/515011/nutrients [Accessed 7 May. 2020].

Tanya has rheumatoid arthritis, a compromised immune system and heart problems. Getting the virus is a risk she cannot take and this is the tenth week that she's been isolating at home with her husband and teenage daughter. But how long will this last and will she have to self isolate in her own home away from her family for the foreseeable future, if her daughter goes back to school? Tanya talks to Claudia about the impact of the pandemic on her life and says why those in the shielding group must not be forgotten. The arrival of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the human population has popularised vocabulary that was previously the preserve of scientists and medics. In just a matter of weeks, phrases like the R Number, Herd Immunity, Case Fatality Rate and All Cause Mortality have become part of everyday language. A new pandemic lexicon has emerged. Inside Health regular Dr Margaret McCartney and Professor Carl Heneghan, Director of the Centre for Evidence Based Medicine at the University of Oxford, discuss the meanings of these very precise descriptions and reveal their personal bugbears, the misuse of such terms. And in her final visit for this series to University Hospital Southampton, Inside Health's Erika Wright, talks again to Trevor Smith, Divisional Director for Medicine, about the enormous challenges ahead as the hospital adapts to living with Covid-19. And she talks about the Banksy art work currently hanging at the hospital which reveals a Super Nurse displacing the traditional comic book superheroes, Batman and Spiderman. Healthcare workers have been lionised as heroes, putting themselves on the front line, risking their own lives, to save others. It's a sentiment which troubles some. Dr Michael FitzPatrick, a gastroenterologist in Oxford and Co-chair of the Royal College of Physicians Trainees Committee, describes why heroes are almost entirely the wrong comparators for healthcare workers. Producer: Fiona Hill Clips used in programme: Batman theme by Danny Elfman (composer) from Batman (1989) Copyright Warner Bros. Avengers Theme by Alan Sivestri (composer) from The Avengers copyright Disney Clip from Infinity War , Joe Russo, Anthony Russo (Directors) Copyright Disney Clip from Justice League by Zac Snyder and Joss Whedon (Directors) Copyright Warner Bros Clip from Iron Man by Jon Favreau (director) copyright Disney Clip from Avengers Endgame by Joe Russo, Anthony Russo (directors). Copyright Disney

Dr. John Fleetham sits down with Drs. David Lipson and Jorgen Vestbo to discuss the article "Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in COPD Patients".

This likely to be part 1 of many on the topic. In this episode we seek to define what purpose is, why we need it, and how to go about starting to find yours. One of the suggested approaches is based on the concept that your individual personality is at the center of this journey. We've created a simple app, called Own My Life (http://ownmy.life/) to help identify your personality traits, give you some ideas on what those traits mean.References:Purpose in Life and Its Relationship to All-Cause Mortality and Cardiovascular Events - A Meta-Analysishttps://journals.lww.com/psychosomaticmedicine/Abstract/2016/02000/Purpose_in_Life_and_Its_Relationship_to_All_Cause.2.aspxFred Silverstone : Finding Purpose in Lifehttps://www.health.harvard.edu/staying-healthy/finding-purpose-in-lifeDan Pink: Drivehttps://www.goodreads.com/book/show/6452796-driveDan Gilbert: Happinesshttps://blog.ted.com/ten-years-later-dan-gilbert-on-life-after-the-surprising-science-of-happiness/Daniel Kahneman: Thinking Fast and Slowhttps://www.goodreads.com/book/show/11468377-thinking-fast-and-slowSHRM: Job Satisfactionhttps://www.shrm.org/ResourcesAndTools/business-solutions/Documents/2015-job-satisfaction-and-engagement-report.pdfThe Search for Purpose in Life: An Exploration of Purpose, the Search Process, and Purpose Anxietyhttps://repository.upenn.edu/mapp_capstone/60/?utm_source=repository.upenn.edu/mapp_capstone/60&utm_medium=PDF&utm_campaign=PDFCoverPages

In this episode Sal, Adam & Justin speak with good friend and author Max Lugavere about his newest book, The Genius Life. Health is important to everybody. (1:41) Is Max getting into ‘tiffs' over social media? (3:40) Making the case for organic vs non-organic. (6:24) Endocrine disruptors and their effect on our hormones. (9:45) The importance of seeking out the opposing view from your own. (14:08) Why is vegans' anger so misplaced? (17:50) The rising popularity of the carnivore diet. (21:30) Don't Fork Around! The value of dietary protein. (24:00) Do not be afraid of a good quality salt! (27:05) How ultra-processed foods highjack your hunger levels. (31:34) What you eat vs when you eat and its impact on your circadian rhythm. (32:29) Are your lights carcinogenic to your health? (37:15) The Vigger Trigger. The importance of thermal exercise. (43:06) Chronic use of anticholinergic drugs and the dangers to our body. (52:05) What's the problem with heating plastic containers in the microwave? (54:38) Fish consumption and mercury toxicity. (56:34) Taking caution when taking Nonsteroidal Anti-inflammatory Drugs (NSAIDs). (58:45) Knowledge is power. (1:02:17) The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary. (1:07:07)   Related Links/Products Mentioned February Promotion: MAPS Split ½ off! **Code “SPLIT50” at checkout** Pre-order ‘The Genius Life' by Max Lugavere Leader of Largest US Organic Food Fraud Gets 10-Year Term Mind Pump 990: Max Lugavere on the Dangers of Plastics, Building a Social Media Page, Coping with Loss & MORE BPA levels in humans may be much higher than previously thought Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life - Book by Max Lugavere and Paul Grewal Mind Pump 1227: The 5 Most Important Supplements to Take Sodium Intake and All-Cause Mortality over 20 Years in the Trials of Hypertension Prevention Redmond Real Salt ‘Ultraprocessed' foods may make you eat more, clinical trial suggests Lux Light Meter Free University of Eastern Finland: Frequent Sauna use Associated With Lower Cardiovascular Death Rate in men and Women Visit Infrared Sauna for an exclusive offer for Mind Pump listeners! Do Ibuprofen and NSAIDs Affect Athletic Performance? Visit NED for an exclusive offer for Mind Pump listeners! Mind Pump Free Resources Featured Guest/People Mentioned Max Lugavere (@maxlugavere)  Instagram Website Podcast Ellen Vora, MD (@ellenvoramd)  Instagram Layne Norton, PhD (@biolayne)  Instagram

Podcast Notes Key Takeaways If you’re going to eat a piece of produce’s skin or peel, buy organicProtein is the most satiating macronutrient; to facilitate weight loss, eat more proteinIf you’re eating a healthy, whole foods-heavy diet, aim to consume 3-5 grams of sodium per day (double what the American Heart Association recommends)Avoid seat salt—it’s packed with microplastics; Himalayan pink salt is bestTry to get 30 minutes of 1,000 lux intensity light before noon each day—this helps set the circadian rhythm(There are a variety of phone apps that allow you to measure an environment’s light intensity)Chronic use of anticholinergic drugs (i.e., antihistamines, Benadryl, and many sleep aids) is associated with a dramatically increased risk for dementiaOne of the best things you can do to limit exposure to endocrine-disrupting chemicals: stop storing/cooking food in plasticRead the full notes @ podcastnotes.orgIn this episode Sal, Adam & Justin speak with good friend and author Max Lugavere about his newest book, The Genius Life. Health is important to everybody. (1:41) Is Max getting into ‘tiffs’ over social media? (3:40) Making the case for organic vs non-organic. (6:24) Endocrine disruptors and their effect on our hormones. (9:45) The importance of seeking out the opposing view from your own. (14:08) Why is vegans' anger so misplaced? (17:50) The rising popularity of the carnivore diet. (21:30) Don’t Fork Around! The value of dietary protein. (24:00) Do not be afraid of a good quality salt! (27:05) How ultra-processed foods highjack your hunger levels. (31:34) What you eat vs when you eat and its impact on your circadian rhythm. (32:29) Are your lights carcinogenic to your health? (37:15) The Vigger Trigger. The importance of thermal exercise. (43:06) Chronic use of anticholinergic drugs and the dangers to our body. (52:05) What’s the problem with heating plastic containers in the microwave? (54:38) Fish consumption and mercury toxicity. (56:34) Taking caution when taking Nonsteroidal Anti-inflammatory Drugs (NSAIDs). (58:45) Knowledge is power. (1:02:17) The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary. (1:07:07)   Related Links/Products Mentioned February Promotion: MAPS Split ½ off! **Code “SPLIT50” at checkout** Pre-order ‘The Genius Life’ by Max Lugavere Leader of Largest US Organic Food Fraud Gets 10-Year Term Mind Pump 990: Max Lugavere on the Dangers of Plastics, Building a Social Media Page, Coping with Loss & MORE BPA levels in humans may be much higher than previously thought Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life - Book by Max Lugavere and Paul Grewal Mind Pump 1227: The 5 Most Important Supplements to Take Sodium Intake and All-Cause Mortality over 20 Years in the Trials of Hypertension Prevention Redmond Real Salt ‘Ultraprocessed’ foods may make you eat more, clinical trial suggests Lux Light Meter Free University of Eastern Finland: Frequent Sauna use Associated With Lower Cardiovascular Death Rate in men and Women Visit Infrared Sauna for an exclusive offer for Mind Pump listeners! Do Ibuprofen and NSAIDs Affect Athletic Performance? Visit NED for an exclusive offer for Mind Pump listeners! Mind Pump Free Resources Featured Guest/People Mentioned Max Lugavere (@maxlugavere)  Instagram Website Podcast Ellen Vora, MD (@ellenvoramd)  Instagram Layne Norton, PhD (@biolayne)  Instagram

http://www.usefulscience.org/podcast/28 This week we're talking about red meat vs. the world Music by Solomon Krause-Imlach. Follow us @usefulsci or email us at podcast@usefulscience.org. Show Notes Mathematical Optimization Assessing the Role of Cattle in Sustainable Food Systems Comparison of Nutritional Quality Cronometer app Effects of red meat, white meat, and nonmeat protein sources on atherogenic lipoprotein measures in the context of low compared with high saturated fat intake: a randomized controlled trial Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Cohort Studies Reduction of Red and Processed Meat Intake and Cancer Mortality and Incidence: A Systematic Review and Meta-analysis of Cohort Studies Patterns of Red and Processed Meat Consumption and Risk for Cardiometabolic and Cancer Outcomes: A Systematic Review and Meta-analysis of Cohort Studies

Dr. Merv Travers is a Senior Research Scholar working in the area of low back pain, tendon pain and exercise rehabilitation at the School of Physiotherapy, The University of Notre Dame Australia. In today's episode, Merv discusses what exactly strength training is, why it’s important for all of our bodies and how physiotherapists can get their patients started and progressing. And of course my son, Rylan, had to compete with his sister in podcast recording (and special blooper takes at the end). Check out the reference list below Merv kindly put together for us! More about Merv...he completed his PhD at Curtin University where he also maintains an Adjunct Research Fellow role. His teaching areas include anatomy and exercise rehabilitation. He has a Masters of Manipulative Therapy and is a qualified strength & conditioning coach (Australian Strength and Conditioning Association – Level 2). Merv’s clinical background includes working in professional rugby union and he provides clinical consultation for complex musculoskeletal conditions at Star Physio, WA. Merv guest lectures nationally and internationally on the topics of strength and conditioning for physiotherapists and tendinopathy rehabilitation, as well as runs an international strength conditioning course for physiotherapists. Optimise Rehab - courses for Strength and Conditioning courses for physios Some key references pertaining to some of this things we spoke about: Public Health and strength training: Steele, J., Fisher, J., Skivington, M., Dunn, C., Arnold, J., Tew, G., . . . Winett, R. (2017). A higher effort-based paradigm in physical activity and exercise for public health: making the case for a greater emphasis on resistance training. BMC Public Health, 17(1), 300. Dankel, S. J., Loenneke, J. P., & Loprinzi, P. D. (2016). Determining the Importance of Meeting Muscle-Strengthening Activity Guidelines: Is the Behavior or the Outcome of the Behavior (Strength) a More Important Determinant of All-Cause Mortality? Mayo Clin Proc, 91(2), 166-174. Strain, T., Fitzsimons, C., Kelly, P., & Mutrie, N. (2016). The forgotten guidelines: cross-sectional analysis of participation in muscle strengthening and balance & co-ordination activities by adults and older adults in Scotland. BMC Public Health, 16(1), 1108. Physio knowledge of guidelines: Lowe, A., Littlewood, C., McLean, S., & Kilner, K. (2017). Physiotherapy and physical activity: a cross-sectional survey exploring physical activity promotion, knowledge of physical activity guidelines and the physical activity habits of UK physiotherapists. BMJ Open Sport & Exercise Medicine, 3(1) Lifting with a neutral spine: Saraceni, N., Kent, P., Ng, L., Campbell, A., Straker, L., & O'Sullivan, P. (2019). To Flex or Not to Flex? Is There a Relationship Between Lumbar Spine Flexion During Lifting and Low Back Pain? A Systematic Review With Meta-Analysis. J Orthop Sports Phys Ther, 1-50 Achilles tendon pain and loading: Murphy, M., Travers, M., Gibson, W., Chivers, P., Debenham, J., Docking, S., & Rio, E. (2018). Rate of Improvement of Pain and Function in Mid-Portion Achilles Tendinopathy with Loading Protocols: A Systematic Review and Longitudinal Meta-Analysis. Sports Medicine. Placebo and Exercise: Crum, A. J., & Langer, E. J. (2007). Mind-set matters: exercise and the placebo effect. Psychol Sci, 18(2), 165-171. Minimum strength dosage: Androulakis-Korakakis, P., Fisher, J. P., & Steele, J. (2019). The Minimum Effective Training Dose Required to Increase 1RM Strength in Resistance-Trained Men: A Systematic Review and Meta-Analysis. Sports Medicine.