Gastroenterology

A Review of Helicobacter Pylori

Play Episode Listen Later Apr 2, 2015 13:40

A review article in the April 2015 issue of Gastroenterology looks at the effects of Helicobacter pylori infection and challenges to and benefits of its eradication.

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Mucosal Impedance Discriminates GERD from Non-GERD Conditions

Play Episode Listen Later Apr 2, 2015 13:00

A study in the February issue of Gastroenterology looked at mucosal impedance (MI) patterns in patients with GERD and common nonreflux conditions, to assess MI patterns before and after treatment with proton pump inhibitors and to compare performance.

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A Review of Gut–Liver Axis in Alcoholic Liver Disease

Play Episode Listen Later Feb 14, 2015 16:26

A review article in the January issue of Gastroenterology summarizes recent findings and highlights emerging trends in the gut–liver axis relevant to alcoholic liver disease. Dr. Kuemmerle interviews author Dr. Gyongyi Szabo

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Clinical Management of Eosinophilic Esophagitis

Play Episode Listen Later Dec 31, 2014 19:11

A review article in the December issue of Gastroenterology looks at current options and new advances in management of eosinophilic esophagitis. Dr. Kuemmerle speaks with the co-author of this review, Dr. Evan Dellon.

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Comparing Fecal Immunochemical Tests and Colonoscopy in Familial Colorectal Cancer Screening

Play Episode Listen Later Nov 26, 2014 12:59

A study in the November issue of Gastroenterology shows results of a controlled randomized trial to compare the efficacy of repeated fecal immunochemical tests (FITs) and colonoscopy in detecting advanced neoplasia in family members of patients w/ CRC.

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Risk of Upper Gastrointestinal Bleeding from Combinations of Drugs

Play Episode Listen Later Oct 15, 2014 16:13

A study in the October issue of Gastroenterology estimates the risk of upper gastrointestinal bleeding during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inhibitors (COX-2 inhibitors), and low-dose aspirin with other drugs.

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Vedolizumab for Crohn's Patients After TNF Therapy Has Failed

Play Episode Listen Later Sep 8, 2014 16:54

A study in the September issue of Gastroenterology evaluated the effects of vedolizumab induction therapy for patients with Crohn's disease for whom tumor necrosis factor (TNF) antagonists have already failed. Dr. Kuemmerle speaks with Dr. Bruce E. Sands

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Factors That Could Affect Colorectal Cancer Screening Strategies

Play Episode Listen Later Aug 4, 2014 25:13

Two related studies in the August issue of Gastroeneterology discuss factors that could affect colorectal cancer screening strategies, including age, sex, race, ethnicity, and whether or not repeat colonoscopy is advisable within ten years.

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Adverse Outcomes Associated with Drug-Induced Liver Injury

Play Episode Listen Later Jul 2, 2014 17:30

A study in the July issue of Gastroenterology sheds new light on adverse outcomes associated with drug-induced liver injury. Dr. Kuemmerle speaks with author Dr. Robert J. Fontana

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Managing Celiac Disease Beyond a Gluten-Free Diet

Play Episode Listen Later May 30, 2014 19:18

An editorial in the June issue of Gastroenterology discusses recent findings that could help physicians and patients manage celiac disease beyond a gluten-free diet. Dr. Kuemmerle speaks with author Dr. Sheila Crowe.

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Impact of the Hepatopulmonary Syndrome MELD Exception Policy on Outcomes of Patients After Liver Transplantation

Play Episode Listen Later May 2, 2014 14:05

An article in the May issue of Gastroenterology analyzed the UNOS database to determine the impact of the HPS MELD exception policy on outcomes of post-liver transplantation patients. Dr. Kuemmerle speaks with author Dr. David S. Goldberg

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Anti-Tumor Necrosis Factor Monotherapy vs Combination Therapy for Inflammatory Bowel Disease

Play Episode Listen Later Apr 2, 2014 18:27

An editorial in the April issue of Gastroenterology compares anti-tumor necrosis factor monotherapy with combination therapy for inflammatory bowel disease. Dr. Kuemmerle speaks with co-author Dr. Corey A. Siegel

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Telaprevir Twice Daily Is Noninferior to Telaprevir Every 8 Hours for Chronic Hepatitis C

Play Episode Listen Later Mar 21, 2014 14:52

A study in the March issue of Gastroenterology examined the safety and efficacy of 2X daily telaprevir in treatment-naive patients with chronic HCV genotype 1 infection, including those with cirrhosis. Dr. Kuemmerle speaks to author Dr. Maria Buti.

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Efficacy of an Interferon-and-Ribavirin-Free Regimen of Direct-Acting Antivirals in Patients with Chronic HCV Infection

Play Episode Listen Later Feb 4, 2014 14:41

A study in the February issue of Gastroenterology examined the safety and efficacy of an interferon-free, ribavirin-free regimen of direct-acting antivirals in patients with chronic HCV infection. Dr. Kuemmerle speaks to Dr. Gregory T. Everson.

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Subcutaneous Golimumab Induces and Maintains Clinical Response and Remission in Patients with Moderate-to-Severe Ulcerative Colitis

Play Episode Listen Later Jan 31, 2014 18:27

Two studies in the January issue of Gastroenterology show that subcutaneous golimumab induces and maintains clinical response and remission in patients with moderate-to-severe ulcerative colitis; Dr. Kuemmerle speaks to Dr. Brian G. Feagan

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Association Between Alanine Aminotransferase and Risk Factors for Atherogenesis

Play Episode Listen Later Dec 3, 2013 13:52

A study in the December issue of Gastroenterology examined the relationship between low–normal and high–normal levels of alanine aminotransferase (ALT) and various cardiovascular risk factors; Dr. Kuemmerle speaks to first author Dr. M. Shadab Siddiqui

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Long-term Intake of Dietary Fiber and Risk of Crohn's Disease and Ulcerative Colitis

Play Episode Listen Later Nov 6, 2013 18:20

A prospective study in the November issue of Gastroenterology looked at associations between long-term intake of dietary fiber and risk of incident Crohn's disease or ulcerative colitis; Dr. Kuemmerle speaks to Dr. Ashwin Ananthakrishnan.

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Early Administration of Azathioprine in Treatment of Crohn's Disease

Play Episode Listen Later Oct 3, 2013 19:19

Two related studies in the October issue of Gastroenterology look at early administration of azathioprine in the management of patients with Crohn's disease.

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Pathogenesis of Primary Sclerosing Cholangitis and Advances in Diagnosis and Management

Play Episode Listen Later Sep 7, 2013 19:14

A review article in the September issue of Gastroenterology takes a comprehensive look at current understanding of primary sclerosing cholangitis (PSC) and discusses important topics for future studies

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No Effects of Gluten in Patients with Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of FODMAPs

Play Episode Listen Later Aug 1, 2013 15:54

A study in the August Gastroenterology found no effect of gluten in patients with non-celiac gluten sensitivity after also reducing fermentable, poorly absorbed, short-chain carbohydrates. Dr. Kuemmerle speaks to Dr. Peter GIbson

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Should Surveillance After Radiofrequency Ablation of Barrett's Esophagus Be Stopped? A Glass Half Full

Play Episode Listen Later Jul 3, 2013 19:58

Three studies in the July issue of Gastroenterology report on the durability of radiofrequency ablation therapy for Barrett's esophagus. Dr. Kuemmerle speaks to the author of an editorial accompanying the studies, Dr. Douglas A. Corley.

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Defining Acute-on-Chronic Liver Failure in the East and West

Play Episode Listen Later Jun 4, 2013 11:16

An editorial in the June issue of Gastroenterology discusses the urgent need to establish a worldwide definition for acute-on-chronic liver failure (ACLF). Dr. Kuemmerle speaks to author Dr. Jasmohan S Bajaj.

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A Historical Perspective on Clinical Advances in Pancreatic Diseases

Play Episode Listen Later May 3, 2013 23:35

This year's annual, special “13th” issue of Gastorenterology is entitled, “The Pancreas: Biology, Diseases, and Therapy.” Dr. Kuemmerle speaks to Dr. Anil Rustgi, author of a commentary in that issue on history of clinical advances in pancreatic disease.

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Hepatocellular Benign Tumors: Classification and Care

Play Episode Listen Later May 3, 2013 15:07

A review article in the May issue of Gastroenterology looks at the molecular pathways involved in benign hepatocellular tumors and discusses how this basic knowledge has been progressively translated into personalized clinical care.

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Uncovering Hidden Information in Achalasia Using Esophageal Pressure Topography

Play Episode Listen Later Apr 4, 2013 22:16

An editorial in the April issue of Gastroenterology looks at how the introduction of esophageal pressure topography has changed our understanding of achalasia and esophageal motor diseases. Dr. Kuemmerle speaks to author Dr. John E. Pandolfino of Northwes

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CDC and USPSTF 2012 Screening Recommendations for Hepatitis C Virus Infection

Play Episode Listen Later Mar 2, 2013 11:59

. A commentary in the March of Gastroenterology takes an overview of recent differing screening recommendations from the CDC and USPSTF for Hepatitis C Virus Infection. Dr. Kuemmerle speaks to Dr. Fasiha Kanwal

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Phenotypic Identification and Classification of Functional Defecatory Disorders Using High-Resolution Anorectal Manometry

Play Episode Listen Later Feb 1, 2013 13:46

A study in the February issue of Gastroenterology sought to characterize phenotypic variation in constipated patients through high-resolution anorectal manometry. Dr. Kuemmerle discusses the results with Dr. Adil Bharucha of the Mayo Clinic.

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When the Spleen Gets Tough, the Varices Get Going

Play Episode Listen Later Jan 4, 2013 13:57

Two papers in the January issue of Gastroenterology seek to identify noninvasive tests that can evaluate patients w/ cirrhosis for complications such as portal hypertension and varices. Dr. Kuemmerle speaks to editorial co-author Dr. Guadalupe Garcia-Tsao

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Efficacies of Biliary and Pancreatic Sphincterotomy in Treatment of Idiopathic Recurrent Acute Pancreatitis

Play Episode Listen Later Dec 4, 2012 16:41

A study in the December issue of Gastroenterology finds that among patients with pancreatic sphincter dysfunction, biliary sphincterotomy or a combination of biliary and pancreatic sphincterotomy similarly prevent acute pancreatitis; with Dr. Gregory Cote

treatments gastroenterology recurrent pancreatic idiopathic biliary acute pancreatitis

Hormone Therapy Increases Risk of Ulcerative Colitis, But Not Crohn's Disease

Play Episode Listen Later Nov 2, 2012 17:32

A study in the November issue of Gastroenterology found that postmenopausal hormone therapy was associated with an increased risk of ulcerative colitis, but not Crohn's disease. Dr. Kuemmerle discusses these findings with Dr. Andrew T. Chan.

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New Risk-Stratification Biomarker Panel for Barrett's Esophagus

Play Episode Listen Later Sep 28, 2012 15:01

A new population-based study in the October issue of Gastroenterology reveals a new risk-stratification biomarker panel for Barrett's esophagus. Dr. Kuemmerle speaks with author Dr. Rebecca C. Fitzgerald.

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Guidelines for Colonoscopy Surveillance After Screening and Polypectomy

Play Episode Listen Later Aug 30, 2012 15:38

The US Multi-Society Task Force on Colorectal Cancer has revised and updated its guidelines for colonoscopy surveillance after screening and polypectomy. Dr. Kuemmerle speaks to author Dr. David A. Lieberman of Oregon Health and Science University

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Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma

Play Episode Listen Later Aug 1, 2012 18:11

An article in the August issue of Gastroenterology provides consensus recommendations for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma. Dr. Kuemmerle speaks w/ author Dr. Jausz Jankowski.

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Multi-Society Sedation Curriculum for Gastrointestinal Endoscopy

Play Episode Listen Later Jun 27, 2012 19:28

The MSCGE was developed by the four national GI societies to address the need for a complete and programmatic approach to the training of procedure sedation. Dr. Kuemmerle speaks to Committee Chair Dr. John Vargo about the curriculum.

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Multi-Society Guideline for the Diagnosis and Management of Non-alcoholic Fatty Liver Disease

Play Episode Listen Later Jun 1, 2012 24:03

Three GI societies have developed a new practice guideline for the diagnosis and management of Non-Alcoholic Fatty Liver Disease. Dr. Kuemmerle speaks to author Dr. Naga Chalasani about these recommendations.

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Hepatic Cell–Type Specific Gene Expression is a Better Predictor of HCV Treatment Outcome than IL28B Genotype

Play Episode Listen Later Apr 24, 2012 18:48

A study in the May issue of Gastroenterology finds that cell-type–specific expression pattern of ISGs varies among patients with different IL28B genotypes and is a strong predictor of response to interferon-based treatment. Featuring Dr. Jordan Feld.

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Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis

Play Episode Listen Later Mar 27, 2012 22:18

A comprehensive review article in the April issue of Gastroenterology looks at the role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis. Dr. Kuemmerle speaks to author Dr. Kenneth Cusi.

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GC-SF Mobilizes CD34+ Cells and Improves Survival of Patients with Acute-on-Chronic Liver Failure

Play Episode Listen Later Mar 2, 2012 18:36

A study in the March issue of Gastroenterology examined whether mobilization of bone marrow–derived stem cells with granulocyte colony–stimulating factor (G-CSF) might promote hepatic regeneration for patients with acute-on-chronic liver failure (ACLF).

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Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas

Play Episode Listen Later Feb 21, 2012 20:41

A study in the February issue of Gastroenterology assessed colorectal neoplasm detection by a next-generation sDNA test and effects of covariates on test performance. Dr. Kuemmerle speaks to first author Dr. David A. Ahlquist

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Maintenance of Remission Among Patients With Crohn's Disease on Antimetabolite Therapy Following Infliximab Therapy

Play Episode Listen Later Dec 22, 2011 16:05

Maintenance of Remission Among Patients With Crohn's Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped. Dr. Kuemmerle speaks to the first author of this study in the January issue of Gastroenterology, Prof. Edouard Louis.

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Current Interferon-Free Treatment Regimens for Hepatitis C

Play Episode Listen Later Dec 1, 2011 16:43

An editorial in the December issue of Gastroenterology looks at the development of DAAs directed at multiple targets in the HCV life cycle and asks, “Are we ready for interferon-free treatment regimens?” Dr. Kuemmerle speaks to co-author Dr. Anna Lok

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Increased Risk of Nonmelanoma Skin Cancers Among Individuals With IBD

Play Episode Listen Later Nov 2, 2011 14:33

A study in the November issue of Gastroenterology looks at the risk of nonmelanoma skin cancer (NMSC) among individuals with inflammatory bowel disease (IBD). Dr. Kuemmerle speaks to study co-author Dr. Harminder Singh

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Prevalence of Celiac Disease Among Patients With Nonconstipated Irritable Bowel Syndrome

Play Episode Listen Later Oct 1, 2011 15:38

A study in the October issue of Gastroenterology evaluated the prevalence of celiac disease antibodies and biopsy-confirmed CD among patients with nonconstipated IBS in a large US population. Dr. Kuemmerle speaks to author Dr. Brooks Cash.

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Changes in Postprandial Lipid Clearance and Blood Glucose Homeostasis Following Vertical Sleeve Gastrectomy in Rats

Play Episode Listen Later Sep 1, 2011 18:56

Two studies in the September issue of Gastroenterology look at the effects of vertical sleeve gastrectomy (VSG) on plasma lipid levels and metabolism. Dr. Kuemmerle speaks to two of the co-authors of both studies.

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Durability of Radiofrequency Ablation in Barrett's Esophagus with Dysplasia

Play Episode Listen Later Aug 2, 2011 15:07

A study in the August issue of Gastroenterology assessed long-term rates of eradication, safety, and durability of radiofrequency ablation in patients with Barrett's esophagus. Dr. Kuemmerle speaks to author Dr. Nicholas Shaheen of UNC Chapel Hill

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Fruit, Vegetables, and Folate: The Evidence for Cancer Prevention

Play Episode Listen Later Jul 1, 2011 14:18

Two studies in the July issue of Gastroenterology examine the relationship between fruits, vegetables, folate, and colorectal cancer, and suggest that potential associations are more complex than first considered. Dr. Kuemmerle speaks to Dr. Andrew Chan

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Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

Play Episode Listen Later Jun 3, 2011 16:22

A review in the June issue of Gastroenterology discusses the effects of autophagy on hepatic and pancreatic physiology, and the contribution of this degradative process to diseases of the liver and pancreas. Dr. Kuemmerle speaks with author Dr. Mark Czaja

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Aspirin or Nonsteroidal Anti-inflammatory Drug Use Increases Risk for Diverticulitis and Diverticular Bleeding

Play Episode Listen Later May 6, 2011 10:52

A study in the May issue of Gastroenterology examines the influence of aspirin and NSAID use on risk of diverticulitis and diverticular bleeding in a large prospective cohort. Dr. Kuemmerle speaks w/ author Dr. Lisa Strate of the University of Washington

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Microscopic Colitis

Play Episode Listen Later Apr 5, 2011 14:13

A comprehensive review on recent findings about the clinical features, diagnosis, epidemiology, pathophysiology, and treatment of microscopic colitis appears in the April issue of Gastroenterology. Dr. Kuemmerle speaks with co-author Dr. Darrell S. Pardi.

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Management of Barrett's Esophagus

Play Episode Listen Later Mar 18, 2011 20:29

The AGA releases its medical position statement and technical review on the management of Barrett's esophagus in the March issue of Gastroenterology. Dr. Kuemmerle speaks with a co-author of both documents, Dr. John Inadomi.

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Changes in Insulin Sensitivity and Body Weight Due to Peginterferon and Ribavirin Therapy for Hepatitis C

Play Episode Listen Later Feb 18, 2011 15:18

A study in the February Gastroenterology looks at changes in insulin resistance and weight in patients with chronic hepatitis C during and after peginterferon and ribavirin therapy. Dr. Kuemmerle speaks with lead author Dr. Hari S. Conjeevaram.

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