Podcasts about observational studies

How much can a change in diet influence symptoms of mental health disorders? Why are a diversity of plants and whole foods so important to include, and ultra processed foods so important to remove? Why are inflammation and microbe diversity in the gut so key to this question? What does this research mean for the life-style medicine movement and to world food policy?In this episode we have the exploding new field of nutritional psychiatry to get to grips with, that is the way our diet can influence and even treat mental health conditions. We're going to be discussing the historical separation of mind and body by science, which has led to scepticism that diet could influence mental health outcomes; the new understanding of the importance of diversity in our microbiome and inflammation to our mood and mental state; our main topic which is going to be the radical results of recent trials showing large changes in cognitive and mental health outcomes when diet is altered; we'll get into the foods that can bring about that change and why they work; and we're going to be getting into the reasons for the broken industrialised food environment that has contributed to the current mental health epidemic in the west.Fortunately, to understand this complex new field, our guest today is the very scientist that risked her reputation to conduct the first trials, facing considerable pushback, only to shift the consensus remarkably quickly with some top science, Felice Jacka. She is the Deakin University Distinguished Professor of Nutritional Psychiatry in Melbourne, the founder and director of the Food & Mood Centre, and of the International Society of Nutritional Psychiatry; She has been cited in over 100 institutional directives for food policy including the World Health Organization and UNICEF; and she is also the author of two books on this for the general public, the children's book “There's a Zoo in my Poo” and for adults “Brain Changer: How diet can save your mental health” which we'll be covering today. Her impact has been so high on public health that in 2021 she was awarded the Order of Australia for her services to nutritional psychiatry.What we discuss:00:00 Intro08:50 The historic separation between mental and physical health. 10:35 People with mental health die about 20 years earlier. 13:30 The connection between the immune system and mental health. 16:20 New microbiome & chronic inflammation research's influence on psychiatry. 20:00 Epigenetics, mitochondria (energy generation) & neurotransmitter influences. 21:15 Gut brain axis & oxidative stress response.33:30 The SMILES trial results and their integration into the consensus. 38:30 Using the Press to shorten the usual 20 year gap between results and policy change. 43:00 Industrialised food is the leading cause of chronic disease & biodiversity loss. 45:00 ‘We're not going to tell people what to eat': the food lobby's ‘nanny state' argument. 50:00 Soil depletion and the soil microbiome. 50:50 The life-style psychiatry movement: Diet, sleep and exercise. 01:05:30 Take out ultra-processed foods - even the nutritionally balanced ones. 01:12:30 Cognitive ability and memory reduced by processed foods. 01:14:45 Nutritional and energetic equivalent foods have totally different outcomes for the microbiome. 01:19:15 Put in a variety of plants - 30 a week. 01:20:20 The mediterranean diet. 01:24:50 Polyphenol science so far. 01:27:00 Emulsifiers and artificial sugars - the mucosal lining of the gut. 01:30:15 Fermented foods - the waste products of the bacteria are beneficial. References:Felice Jacka, “Brain Changer: The Good Mental Health Diet”Felice Jacka, “There's a Zoo in my Poo”Melissa Lane et al, ‘Ultra‐Processed Food Consumption and Mental Health: A Systematic Review and Meta‐Analysis of Observational Studies' paperFelice Jacka' et al, ‘A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial)' Paper

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens.Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves.The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections.Guest-at-a-Glance

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in diagnostics. Barriers include low health literacy and inadequate healthcare systems. Social Determinants of Health Social deprivation leads to worse cardiovascular outcomes, especially among sexual minorities in the U.S. The editorial calls for more equitable healthcare access and anti-stigma efforts. Environmental Factors: Aircraft Noise Higher aircraft noise exposure is linked to worse heart health, urging noise reduction policies for vulnerable populations. Section 3: Prevention in Individuals (35:30 - 55:30) Sedentary Behavior Even with exercise, high sedentary time (over 10.6 hours a day) increases cardiovascular risk. Reducing sedentary time can significantly lower heart disease risk. Intensive Lifestyle Interventions for Diabetes Weight loss and lifestyle changes improve cardiac biomarkers and reduce cardiovascular risk in type 2 diabetes patients. Section 4: Risk Factor Impacts (55:30 - 1:10:00) Hyperlipidemia & Obesity Hyperlipidemia and obesity management, including medications like semaglutide, play key roles in preventing cardiovascular disease. The 2024 ESC hypertension guidelines are also crucial in risk reduction.

Moderator: James P. Rathmell, M.D. Participants: James Hitt, M.D., Ph.D. and Mark C Bicket, M.D., Ph.D. Articles Discussed: Continuation versus Interruption of Buprenorphine/Naloxone in Adult Veterans Undergoing Surgery: Examination of Postoperative Pain and Opioid Utilization in a National Retrospective Cohort Study Building a Better Base for Keeping Buprenorphine on Board for Surgery Transcript

US dementia cases set to double by 2060; Study claims red meat a culprit in cognitive decline—but a close read reveals it's a lot of baloney; Aerobic exercise is best hedge against Alzheimer's; Prevagen ordered to drop memory claims; When a blood pressure cuff is too tight, can it throw off readings? An 80-year-old who takes DHEA wants to add pregnenolone; Oregon hospital patient awarded $900,000 after face catches fire during surgery; LA residents may suffer health consequences of pollutants long after wildfires quenched. 

We know the literature on mechanical CPR devices on mortality in out of hospital cardiac arrest (we DO know this literature, right?), but what about in-hospital arrest? Dr. Jarvis reviews a recent paper that uses the AHA Get With The Guidelines - Resuscitation registry to assess the association between MCDs and mortality. Citations1. Crowley C, Salciccioli J, Wang W, Tamura T, Kim EY, Moskowitz A: The association between mechanical CPR and outcomes from in-hospital cardiac arrest: An observational cohort study. Resuscitation. 2024;May 1;198.2. Rubertsson S, Lindgren E, Smekal D, Östlund O, Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R, et al.: Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: The LINC Randomized Trial. JAMA. 2014;January 1;311(1):53–613. Hardig BM, Lindgren E, Östlund O, Herlitz J, Karlsten R, Rubertsson S: Outcome among VF/VT patients in the LINC (LUCAS IN cardiac arrest) trial—A randomised, controlled trial. Resuscitation. 2017;June;115:155–62.4.  Perkins GD, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, Lamb SE, Slowther A-M, Woollard M, Carson A, et al.: Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial. The Lancet. 2015;385(9972):947–55.5.  Wik L, Olsen J-A, Persse D, Sterz F, Lozano M, Brouwer MA, Westfall M, Souders CM, Malzer R, Van Grunsven PM, et al.: Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial. Resuscitation. 2014;June;85(6):741–8.6. Bonnes JL, Brouwer MA, Navarese EP, Verhaert DVM, Verheugt FWA, Smeets JLRM, Boer M-J de: Manual Cardiopulmonary Resuscitation Versus CPR Including a Mechanical Chest Compression Device in Out-of-Hospital Cardiac Arrest: A Comprehensive Meta-analysis From Randomized and Observational Studies. Ann Emerg Med Annals of emergency medicine. 2016;67(3):349-360.e3.7. Gonzales L, Oyler BK, Hayes JL, Escott ME, Cabanas JG, Hinchey PR, Brown LH: Out-of-hospital cardiac arrest outcomes with “pit crew” resuscitation and scripted initiation of mechanical CPR. The American Journal of Emergency Medicine. 2019;May;37(5):913–20.8. Koster RW, Beenen LF, Van Der Boom EB, Spijkerboer AM, Tepaske R, Van Der Wal AC, Beesems SG, Tijssen JG: Safety of mechanical chest compression devices AutoPulse and LUCAS in cardiac arrest: a randomized clinical trial for non-inferiority. European Heart Journal. 2017;October 21;38(40):3006–13.9. Primi R, Bendotti S, Currao A, Sechi GM, Marconi G, Pamploni G, Panni G, Sgotti D, Zorzi E, Cazzaniga M, et al.: Use of Mechanical Chest Compression for Resuscitation in Out-Of-Hospital Cardiac Arrest—Device Matters: A Propensity-Score-Based Match Analysis. JCM. 2023;June 30;12(13):4429.10. Youngquist ST, Ockerse P, Hartsell S, Stratford C, Taillac P: Mechanical chest compression devices are associated with poor neurological survival in a statewide registry: A propensity score analysis. Resuscitation. 2016;September;106:102–7.11.  S, Sulzgruber P, Datler P, Keferböck M, Poppe M, Lobmeyr E, Van Tulder R, Zajicek A, Buchinger A, Polz K, et al.: Mechanical chest compression does not seem to improve outcome after out-of hospital cardiac arrest. A single center observational trial. Resuscitation. 2015;November;96:220–5. 12. Morgan S, Gray JJ, Sams W, Uhl K, Gundrum M, McMullan J: LUCAS Device Use Associated with Prolonged Pauses during Application and Long Chest Compression Intervals. Prehospital Emergency Care. doi: 10.1080/10903127.2023.2183294 (Epub ahead of print).13.  Levy M, Yost D, Walker RG, Scheunemann E, Mendive SR: A quality improvement initiative to optimize use of a mechanical chest compression device within a high-performance CPR approach to out-of-hospital cardiac arrest resuscitation. Resuscitation. 2015;July;92:32–7.14.  Li H, Wang D, Yu Y, Zhao X, Jing X: Mechanical versus manual chest compressions for cardiac arrest: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2016;December;24(1):10.15.  Sheraton M, Columbus J, Surani S, Chopra R, Kashyap R: Effectiveness of Mechanical Chest Compression Devices over Manual Cardiopulmonary Resuscitation: A Systematic Review with Meta-analysis and Trial Sequential Analysis. WestJEM. 2021;July 19;22(4):810–9.16.  Wang PL, Brooks SC: Mechanical versus manual chest compressions for cardiac arrest. Cochrane Database Syst Rev The Cochrane database of systematic reviews. 2018;20;8:CD007260.17.  Zhu N, Chen Q, Jiang Z, Liao F, Kou B, Tang H, Zhou M: A meta-analysis of the resuscitative effects of mechanical and manual chest compression in out-of-hospital cardiac arrest patients. Crit Care. 2019;December;23(1):100.

About the Mini Series: This informative mini series, comprising of six episodes, is aimed at researchers intrigued by the intricacies of sedentary behavior and physical activity. It offers a comprehensive exploration into the social, emotional, and temporal contexts of these behaviors. With a special focus on understanding how such contexts are measured and their potential influence on interventions, this series serves as a vital resource for those engaged in the field of physical activity and sedentary behavior research. About the Episode Topic: Episode four dives into the diverse methodologies used for measuring the context of physical activity and sedentary behavior. The episode first elucidates the utility and limitations of conventional tools like surveys and questionnaires, shedding light on how they offer insights into individuals' perceptions, beliefs, and attitudes towards exercise and sedentary habits. It also addresses challenges like recall and social desirability bias that can influence the accuracy of the data collected through such self-report methods. Following this, the discussion transitions into observational studies, emphasizing their power to reveal patterns and associations between environmental factors and activity levels, often overlooked by self-reported methods. The episode rounds off with an exploration into the integration of technology in context measurement. It outlines the evolution of wearable devices, smartphone apps, and advanced sensors that offer real-time, objective, and continuous monitoring of physical activity and sedentary behavior. Timestamps: [00:01:00]: Introduction and Episode Overview [00:03:00]: Exploring Surveys and Questionnaires [00:05:00]: Transitioning to Observational Studies [00:07:00]: Discussing the Role of Technology in Context Measurement [00:10:00]: Introduction of Fibion Sens Motion ----------- Want to book a video call with Dr. Miriam Cabrita to discuss your sedentary behavior or physical activity measurements? Here's the link: https://olli.tucalendi.com/miriam-cabrita/videocall-miriam --- This podcast episode is sponsored by Fibion Inc. | Better Sleep, Sedentary Behaviour and Physical Activity Research with Less Hassle --- Collect, store and manage SB and PA data easily and remotely - Discover ground-breaking Fibion SENS --- Learn more about Fibion Flash - a versatile customizable tool with HRV and accelerometry capability.  --- SB and PA measurements, analysis, and feedback made easy.  Learn more about Fibion Research. --- Learn more about Fibion Sleep and Fibion Circadian Rhythm Solutions. --- Fibion Kids - Activity tracking designed for children. --- Explore our Wearables,  Experience sampling method (ESM), Sleep,  Heart rate variability (HRV), Sedentary Behavior and Physical Activity article collections for insights on related articles. --- Refer to our article "Physical Activity and Sedentary Behavior Measurements" for an exploration of active and sedentary lifestyle assessment methods. --- Learn about actigraphy in our guide: Exploring Actigraphy in Scientific Research: A Comprehensive Guide. --- Gain foundational ESM insights with "Introduction to Experience Sampling Method (ESM)" for a comprehensive overview. --- Explore accelerometer use in health research with our article "Measuring Physical Activity and Sedentary Behavior with Accelerometers ". --- For an introduction to the fundamental aspects of HRV, consider revisiting our Ultimate Guide to Heart Rate Variability. --- Follow the podcast on Twitter https://twitter.com/PA_Researcher  Follow host Dr Olli Tikkanen on Twitter https://twitter.com/ollitikkanen  Follow Fibion on Twitter https://twitter.com/fibion  Check our YouTube channel: https://www.youtube.com/@PA_Researcher   

Host Katherine Mallett, MD Guest interviewees Samir Mehta, MD and Monica Kogan, MD, FAAOS, discussing their Training Room article, “Let's Take a Look at the Tape: The Impact of ERAS Video Prompts on Interview Offerings for Orthopaedic Surgery Residency Applicants: A Prospective Observational Study” from the November 15, 2024 issue Article summarized from the November 1, 2024 issue Research article “Odds of Attaining Orthopaedic Leadership Based on Race, Ethnicity, and Sex” Article summarized from the November 15, 2024 issue  Research article “Prophylactic Antibiotic Choice and Deep Infection in Lower Extremity Endoprosthetic Reconstruction: Comparison of Cefazolin, Cefazolin-Vancomycin, and Alternative Regimens” Follow this link to download these and other articles from the November 1, 2024 issue of JAAOS and the November 15, 2024 issue of JAAOS. The JAAOS Unplugged podcast series is brought to you by the Journal of the American Academy of Orthopaedic Surgeons and the AAOS Resident Assembly.

In Episode 105 of the Coffee with Karim Podcast, we dive into the essential foundations of family connection, exploring the power of attention, affection, and approval in parent-child relationships. Discover insights on nurturing bonds, the human need for intimacy, and navigating family challenges in the digital age, including screen time and effective communication. Perfect for parents, educators, and anyone looking to strengthen family ties. More Info on Studies René Spitz's Observational Studies (1940s): René Spitz was a psychoanalyst who studied infants in orphanages and hospitals. He observed that children who lacked maternal care or consistent adult attention developed what he called “anaclitic depression,” showing signs of developmental delays, emotional withdrawal, and increased mortality. His work highlighted the psychological harm caused by emotional neglect, as many infants in orphanages during this period received minimal affection, and caregivers often focused solely on physical needs. Harry Harlow's Experiments with Rhesus Monkeys (1950s): Although not directly on humans, Harlow's work with rhesus monkeys profoundly impacted how we understand attachment. Harlow found that young monkeys preferred soft, comforting "mothers" over wire ones that only provided food. This work suggested that emotional bonds and comfort are vital to development, reinforcing the importance of nurturing environments for infants and challenging the practice in orphanages where emotional support was often overlooked. Romanian Orphanage Studies (1990s): In the 1990s, psychologists and researchers began studying children in Romanian orphanages who had been raised in extremely deprived conditions. These studies found that children raised without consistent caregivers and social interaction had severe cognitive, emotional, and physical delays. Many children experienced attachment disorders, struggled with emotional regulation, and had long-term developmental impacts.

Protein — how much do we need? What's the healthiest way to consume it? Can we get enough from plant-based diets? Until recent decades, protein hasn't been quite as prominent in public health discussions as sugar and fats.  However, with longer lifespans emphasizing the importance of protein for long-term health, and growing confusion around the quality and quantity of protein needed, it has become a highly debated macronutrient. In ‘Your Brain On… Protein', we explore: • The brain health benefits (and general health benefits) of protein • Plant-based protein vs. meat protein, and supplements like protein powders • How much protein we really need to eat every day • Ways we can all introduce more protein into our diets • Why ‘health' influencers are suddenly recommending unusually  high levels of protein consumption • How we measure the quality of proteins, including digestibility and absorption In this episode, we're joined by two fantastic nutrition experts: DR. MATTHEW NAGRA, nutritionist and science communicator. DR. ALAN FLANAGAN, esteemed nutrition scientist (previously featured in ‘Your Brain On… Sugar' and ‘Your Brain On… Fats' ‘Your Brain On' is hosted by neurologists, scientists and public health advocates Ayesha and Dean Sherzai. Drs. Ayesha and Dean are now welcoming patients via the Brain Health Institute: https://brainhealthinstitute.com/ ‘Your Brain On... Protein' • SEASON 3 • EPISODE 10 (SEASON 3 FINALE!) ——— LINKS: Dr. Matt Nagra Instagram: https://www.instagram.com/dr.matthewnagra Website: https://drmatthewnagra.com/  Dr. Alan Flanagan Alan on Instagram: https://www.instagram.com/thenutritionaladvocate Alinea Nutrition: https://www.alineanutrition.com/ ——— REFERENCES: Dietary Patterns and Risk of Dementia: a Systematic Review and Meta-Analysis of Cohort Studies. https://doi.org/10.1007/s12035-015-9516-4 Dietary fat composition and dementia risk. https://doi.org/10.1016/j.neurobiolaging.2014.03.038 Dietary Protein and Amino Acids in Vegetarian Diets—A Review. https://pmc.ncbi.nlm.nih.gov/articles/PMC6893534/ Animal vs Plant-Based Meat: A Hearty Debate. https://pubmed.ncbi.nlm.nih.gov/38934982/ High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and Omnivores. https://pubmed.ncbi.nlm.nih.gov/33599941/ Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults. https://pubmed.ncbi.nlm.nih.gov/36822394/ Digestibility issues of vegetable versus animal proteins: protein and amino acid requirements--functional aspects. https://pubmed.ncbi.nlm.nih.gov/23964409/ Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies and Randomized Trials in Humans. https://doi.org/10.1002/mnfr.201900751 No Difference Between the Effects of Supplementing With Soy Protein Versus Animal Protein on Gains in Muscle Mass and Strength in Response to Resistance Exercise. https://pubmed.ncbi.nlm.nih.gov/29722584/ Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies. https://pubmed.ncbi.nlm.nih.gov/33383165/ The health effects of soy: A reference guide for health professionals. https://pmc.ncbi.nlm.nih.gov/articles/PMC9410752/ The Effect of Plant-Based Protein Ingestion on Athletic Ability in Healthy People—A Bayesian Meta-Analysis with Systematic Review of Randomized Controlled Trials. https://www.mdpi.com/2072-6643/16/16/2748 Effects of high-quality protein supplementation on cardiovascular risk factors in individuals with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. https://doi.org/10.1016/j.clnu.2024.06.013 Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults. https://pubmed.ncbi.nlm.nih.gov/36822394/

The impact of omega-3 fatty acids on chronic disease risk has been a topic of considerable interest and research. The VITAL trial, which assessed the effects of vitamin D and omega-3 supplements on various health outcomes, including cardiovascular disease and cancer, provided insightful findings. Additionally, numerous other supplement trials have examined different dosages and formulations of omega-3s, yielding mixed results. Some trials have highlighted significant benefits, while others have shown minimal impact, leading to ongoing debates in the scientific community. Reconciling this evidence base requires a nuanced understanding of the study populations, dosages, and specific health outcomes investigated. The variability in results can often be attributed to differences in trial design, such as whether the focus was on primary or secondary prevention, the baseline dietary intake of participants, and the specific types of omega-3 supplements used. Understanding these nuances is crucial for making informed recommendations about omega-3 supplementation for chronic disease prevention. In this episode, Professor JoAnn Manson will delve into the complexities of omega-3 research, discussing the VITAL trial in detail, comparing it with other significant studies, and providing insights into how to interpret and reconcile the diverse findings in the context of chronic disease risk. Timestamps: 03:21 The VITAL Trial Explained 05:39 Biological Mechanisms and Observational Studies 07:25 Primary vs. Secondary Prevention 10:47 Key Findings from the VITAL Trial 13:39 Subgroup Analyses and Future Research 19:58 Dosage Considerations and Risks 23:47 Impact of Omega-3 on Chronic Diseases 32:18 Nuances in Omega-3 Research 44:27 Future Research Directions 48:54 Key Ideas Segment (Premium-only) Links: Subscribe to Premium Go to episode page Receive our free weekly email: the Sigma Synopsis Enroll in the next cohort of our Applied Nutrition Literacy course

Join us as we talk with Dr David Liew about the underappreciated condition of gout, dispell some myths and talk about what's changed in recommendations.  This podcast is in collaboration with Medcast and the Quality Use of Medicines Alliance, a provider of health professional education in Australia focused on the quality use of medicines. Check out their resources here.  Arthritis Australia have further information on gout here. The 2015 study by Philip C Robinson is here An Observational Study of Gout Prevalence and Quality of Care in a National Australian General Practice Population 

Send us a Text Message.Diese Woche besprechen wir die Arbeit von Karagiannidis et. al aus Lancet Regional Health Europe zu Mortalität und Kosten von 1 Million beatmeten Intensivpatienten: https://doi.org/10.1016/j.lanepe.2024.100954Mit im Studio: Anian Mair, Wissenschaft. Mitarbeiter der Klinik für Anästhesiologie

Send us a Text Message.In dieser Folge des JC geht es um eine Arbeit von Girardello et al. zur prähospitalen Gabe von Tranexamsäure bei Trauma. Mit im Studio dabei ist Konstantin Urbach, wissenschaftlicher Mitarbeiter der Klinik für Anästhesiologie am UKHDGirardello C, Carron P, Dami F, et al. Evaluation of the prehospital administration of tranexamic acid for injured patients: a state-wide observational study with sex and age-disaggregated analysis. Emergency Medicine Journal  Published Online First: 14 June 2024. doi: 10.1136/emermed-2023-213806

- Today I'd like to tell you about a study by several researchers and clinicians in Italy, including Roberto Cannataro, who spoke at one of our previous H2H events.- The title of this article is Observational Study on a Large Italian Population with Lipedema: Biochemical and Hormonal Profile, Anatomical and Clinical Evaluation, Self-Reported History.- It was published in the peer-reviewed journal International Journal of Molecular Sciences in January 2024.- This work aims to describe the clinical, instrumental, and blood test results of a large population of women affected by lipedema in the lower body.

On this week's episode of the pod, Jess is joined by Dr. David Robert Grimes to discuss various aspects of cancer, including prevalence, survivorship, trends, and prevention. They emphasize the importance of understanding that cancer is a complex disease with various forms and causes. They debunk myths and misinformation surrounding cancer, such as the idea that sugar, sunscreen, or deficiency in vitamin C cause cancer. They also highlight the role of screening programs in early detection and prevention, while cautioning against unnecessary tests and over-treatment. They chat about modifiable risk factors for cancer, such as smoking, obesity, and sun exposure -- as well as cellular changes during the aging process. The conversation takes a positive turn when the two discuss the potential of mRNA vaccines in cancer treatment. They emphasize the importance of critical thinking and skepticism when evaluating cancer-related information, particularly on social media. You don't want to miss this! All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/cant-you-biopsy-that-cancer-trends-are-complicated (00:00) Theme Song (00:20) Intros (02:43) Some Cancer Statistics (05:59) Prevalence and Trends in Cancer (11:53) Debunking Myths and Misinformation (14:00) The Role of Screening Programs (26:05) Modifiable Risk Factors for Cancer (29:07) Debunking Cancer Myths: Sugar, Processed Foods, and Stress (32:42) The Truth About Alcohol and Cancer Risk (35:36) The Role of Observational Studies in Cancer Research (39:34) Do Stress Or Vitamin D Deficiency Cause Cancer? (44:35) Are Cancer "Super Blood Tests" Legit? (45:33) The Promise of mRNA Vaccines in Cancer Treatment Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

Gosh was this a great conversation about her recent paper on specification curve analysis of nutritional observational studies. Here is Dr. Zeraatkar's bio:Dena Zeraatkar, PhD is an Assistant Professor in the Departments of Anesthesia and Health Research Methods, Evidence, and Impact (HEI) at McMaster University. She earned her doctoral degree at McMaster University in the Health Research Methodology graduate program. Following her doctoral training, she pursued postdoctoral training at Harvard Medical School, for which she was awarded a Banting scholarship.Her research centers on evidence synthesis and evaluation—identifying and appraising research to optimally inform healthcare and public health decisions. She often works in areas in which the evidence is complex or conflicting, examples of which include nutrition and COVID-19 therapeutics. For her research, in 2023, she was awarded a Gairdner Early Career Investigator Award.First, it would help to read my comments yesterday on the paper. Dr. Zeraatkar is well-spoken, clear and she explains a complicated topic in simple terms. Her work is exactly the type we love at Sensible Medicine. Stay for her final comment. It made me so happy. Sensible Medicine is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Discover the powerful, growing evidence base between diet and mental health (nutritional psychiatry). We explore the benefits of the Mediterranean diet for Depression, the evidence for supplements and mental health, why inflammation, the gut microbiome and neurogenesis may be key mechanisms involved in diet and mental health, how our eating patterns affect the environment and much, much more... Dr. Lais Bhering Martins is aDietitian and Researcher in the field of Nutritional Psychiatry. Lais is a Scientific Collaborator at the Geneva School of Health Science. Chapters 0:00 Show Intro 3:30 Lais' Journey in Nutritional Psychiatry 6:45 Nutritional Psychiatry 14:55 Mediterranean Diet 28:50 Ketogenic Diet 32:25 Vegetarian Diet 35:40 Diet for Mental Health in Clinical Practice 41:00 Supplements and Gut Health 53:35 Diet and Neurogenesis 1:00:05 Sustainable Food Systems 1:09:05 Changing Dietary Behaviours Show Notes "Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment" by Martins et al. (2019) "Nutritional Psychiatry: Where to Next?" by Jacka (2017) "A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES' trial)" by Jacka et al. (2017) "Food and Mood Centre" https://foodandmoodcentre.com.au/ "Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies" by Lane et al. (2022) "NOVA Food Classification System" https://ecuphysicians.ecu.edu/wp-cont... "Ketogenic Therapy in Serious Mental Illness: Emerging Evidence" by Sarnyai & Palmer (2020) "Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial" by Sethi et al. (2024) "Ketogenic Therapy in Serious Mental Illness: Emerging Evidence" by Jain et al. (2022) "Exploring the role of dietitians in mental health services and the perceived barriers and enablers to service delivery: A cross-sectional study" by Teasdale et al. (2023) "A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED)" by Parletta et al. (2019) "A review of the nutritional challenges experienced by people living with severe mental illness: a role for dietitians in addressing physical health gaps" by Teasdale et al. (2017) "Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?" by Hussain et al. (2016) "Nutrition, adult hippocampal neurogenesis and mental health" by Zainuddin et al (2012) "Western diet is associated with a smaller hippocampus: a longitudinal investigation" by Jacka et al. (2015) "EAT-Lancet Diet Report" https://openaccess.city.ac.uk/id/eprint/21633/8/ "EAT-Lancet Diet Video" https://eatforum.org/learn-and-discover/eat-lancet-explained/ "Seven Countries study" https://www.sevencountriesstudy.com/

Ever pondered how to navigate the vast sea of research on diets and blood pressure without losing your way? Join us as we uncover the layers of a recent Advances in Nutrition paper, presenting a valuable guide for healthcare professionals in the integrative medicine field. Embarking on systematic reviews in dietary research often feels like embarking on a quest for the Holy Grail. In this installment, we express appreciation for the diligence required to scrutinize thousands of studies. Balancing admiration with a critical eye, we meticulously examine the utilization of tools such as AMSTAR and the Cochrane Risk-of-Bias to separate valuable insights from less substantial findings.Aljuraiban GS, Gibson R, Chan DS, Van Horn L, Chan Q. The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies. Adv Nutr. 2024 Jan;15(1):100123. doi: 10.1016/j.advnut.2023.09.011. Epub 2023 Oct 1. PMID: 37783307; PMCID: PMC10831905.Learn more and become a member at www.DrJournalClub.comCheck out our complete offerings of NANCEAC-approved Continuing Education Courses.

On this week's episode of the pod, we'll walk through a study together! Jess leads a journal club session, diving deep into a study about the potential link between prenatal Tylenol use and signs of Autism Spectrum Disorder (measured using language assessments). She shares her approach to understanding research and breaks down a specific study, highlighting crucial elements like research design, sample selection, and how comparison groups are created. Jess analyzes the results, explains the statistics, and examines the study's strengths and limitations. Finally, she sums up the key takeaways and what they mean for future research. This episode is a must-listen for anyone interested in research methods or curious about this topic! All our sources from this episode are available at: https://www.unbiasedscipod.com/episodes/acetaminophen-autism-connection (00:00) Intro and Farewell to Dr. Andrea Love (02:54) Journal Club: Acetaminophen and Autism Spectrum Disorder (03:20) Understanding Autism Spectrum Disorder (08:45) The Relationship Between Tylenol and Autism Spectrum Disorder (09:36) Safety Concerns and Observational Studies (10:35) Causality and Study Design (12:50) Confounding Variables and Observational Studies (14:30) Study: Examining the Relationship of Acetaminophen Use During Pregnancy with Early Language Development in Children (15:54) Reading a Study: Study Design and Statistical Analysis (21:52) How Participants Were Recruited For The Study (24:20) Assessing Language (26:10) Other Variables and Adjustment Factors Considered (28:15) Statistical Analysis (31:20) Study Population and Sample Size (34:17) Comparison of Acetaminophen Users and Non-Users (40:45) Measure of Effect, Odds Ratios, p-Values and Null Values (46:23) Strengths and Limitations of the Study (49:07) Summary and Final Thoughts Interested in advertising with us? Please reach out to advertising@airwavemedia.com, with “Unbiased Science” in the subject line. PLEASE NOTE: The discussion and information provided in this podcast are for general educational, scientific, and informational purposes only and are not intended as, and should not be treated as, medical or other professional advice for any particular individual or individuals. Every person and medical issue is different, and diagnosis and treatment requires consideration of specific facts often unique to the individual. As such, the information contained in this podcast should not be used as a substitute for consultation with and/or treatment by a doctor or other medical professional. If you are experiencing any medical issue or have any medical concern, you should consult with a doctor or other medical professional. Further, due to the inherent limitations of a podcast such as this as well as ongoing scientific developments, we do not guarantee the completeness or accuracy of the information or analysis provided in this podcast, although, of course we always endeavor to provide comprehensive information and analysis. In no event may Unbiased Science or any of the participants in this podcast be held liable to the listener or anyone else for any decision allegedly made or action allegedly taken or not taken allegedly in reliance on the discussion or information in this podcast or for any damages allegedly resulting from such reliance. The information provided herein do not represent the views of our employers. Learn more about your ad choices. Visit megaphone.fm/adchoices

Curious about your micronutrient status? Wonder if you're still deficient even though you take a multivitamin and eat a whole foods diet? Want to know how a simple blood test can tell you exactly what to supplement with and what foods to focus on? Tune in to learn about micronutrient testing--from the mechanisms of testing, to why you might be deficient in the first place, to how you can use this data to optimize and thrive!    In this episode, we will cover micronutrient testing and what trends of deficiency can tell you about your health. Even if you eat “healthy” you can be deficient based on increased demand, inability to absorb or use, inadequate intake. Testing micronutrients can play a turnkey role in your wellness as we can see beyond the nutrient itself and see the story of the deficiency trends to address the root cause of imbalance. Plus we'll explore case studies, from a postmenopausal woman to a carnivore to someone dealing with chronic fatigue and brain fog and discuss actual interventions that made a world of difference for these clients!    Get the Cellular Nutrient Analysis Micronutrient Panel for only $374 with code MNT25 Includes a customized email review from Ali or Becki with diet, lifestyle & supplement recommendations!   Also in this episode:  Episode 261: Micronutrient Testing and Our Personal Results Episode 177: Why You Need Supplements Episode 178: Why You Need Supplements Part 2 Episode 247: Drug Induced Nutrient Deficiency How the Cellular Nutrient Analysis is different from a serum blood test Why you may be deficient despite a healthy diet and supplementation Case Study #1: Postmenopausal Woman with weight gain, anxiety, disrupted sleepThyroid Optimizer B-12 Boost Grassfed Whey Calm and Clear Force of Nature use code ALIMILLERRD Superfood Chicken Nuggets Case Study #2: Biohacker Carnivore doing everything right but under high stressB Complex Adaptogen Boost Case Study #3: Chronic fatigue and brain fogMultidefense with Iron GI Lining Support CoQ10 Complex Carnitine Complex Apple Cider Vinegar Shooter Noble Origins Organ Blend use code ALIMILLERRD ResearchArulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS. Role of Antioxidants and Natural Productsin Inflammation. Oxid Med Cell Longev. 2016;2016:5276130. Epub 2016 Oct 10. Review. PubMed PMID: 27803762; PubMed Central PMCID: PMC5075620. Angelo G, Drake VJ, Frei B. Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials. Crit Rev Food Sci Nutr. 2015;55(14):1968-91. doi: 10.1080/10408398.2014.912199. Review. PubMed PMID: 24941429. Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018 Apr 26;13:757-772. doi: 10.2147/CIA.S158513. eCollection 2018. Review. PubMed PMID: 29731617; PubMed Central PMCID: PMC5927356. Rheaume-Bleue, K. Choosing the Right Vitamin K2: Menaquinone-4 vs Menaquinone-7. Clinical considerations of different forms of vitamin K2. Natural Medicine Journal (October, 2015)  Sanders, TAB., Functional Dietary Lipids, 2016. Linoleic Acid, Shichiri, M., Yoshida, Y., Niki E., 2014, Unregulated Lipid Peroxidation in Neurological Dysfunction, Omega-3 Fatty Acids in Brain and Neurological Health, Retrieved March 23, 2019 from    Sponsors for this episode:  This episode is sponsored by Wild Foods, a company that puts quality, sustainability, and health first in all of their products. They have everything from coffee to turmeric to medicinal mushrooms, and every single product is painstakingly sourced from small farms around the globe. They take their mission seriously to fix the broken food system, and believe real food is medicine. They've partnered with us to give you guys an exclusive discount, so use the code ALIMILLERRD for 12% off your order at WildFoods.co! 

Season 3, Episode 1: "Is Porn Bad For Your Health?" **CONTENT WARNING** This episode contains talk about violence, rape, sex trafficking, child pornography, and racism. Please listen with care.  For transcripts click here   Please support our show! Please consider a tax-deductible donation to our podcast via the Foundation for Delaware County, a 501c3 organization.   Every purchase of RWQ merch also helps support our show!    Please rate and review us on Apple Podcasts or wherever you listen to our podcast–and tell your friends about us!     References Sniewski et al. The assessment and treatment of adult heterosexual men with self-perceived problematic pornography use: A review, Addictive Behaviors, Volume 77, 2018.  Pages 217-224 Hook, J. N., Farrell, J. E., Davis, D. E., Van Tongeren, D. R., Griffin, B. J., Grubbs, J., ... & Bedics, J. D. (2015). Self-forgiveness and hypersexual behavior. Sexual Addiction & Compulsivity, 22(1), 59-70. Fritz, N., Malic, V., Paul, B. et al. Worse Than Objects: The Depiction of Black Women and Men and Their Sexual Relationship in Pornography. Gend. Issues 38, 100–120 (2021). https://doi.org/10.1007/s12147-020-09255-2 Dwulit AD, Rzymski P. The Potential Associations of Pornography Use with Sexual Dysfunctions: An Integrative Literature Review of Observational Studies. Journal of Clinical Medicine. 2019; 8(7):914. https://doi.org/10.3390/jcm8070914 Hakkim S, Parsa AD, Arafat SMY, et al. Pornography—Is It Good for Sexual Health? A Systematic Review. Journal of Psychosexual Health. 2022;4(2):111-122. doi:10.1177/26318318221088949

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Immortal Time Bias in Observational Studies with Kabir Yadav, MDCM, MS, MSHS. Related Content: Immortal Time Bias in Observational Studies

Chaque hiver, les compléments alimentaires font un retour retentissant sur le devant de la scène. On leur prête de nombreuses vertus : réduction des infections, apport en nutriments, boost du système immunitaire. Mais sont-ils réellement efficaces ou servent-ils seulement à alléger notre porte-feuille avant les fêtes de fin d'année ? On décrypte ça dans ce nouveau format Futura SANTÉ.

Ever wondered about the intricate connections between observational studies and the Estimand framework in the pharmaceutical industry? How do the challenges in multi-country primary data collection unfold, and what crucial role do assumptions play in propensity score methods? In this captivating episode, I'm excited to have Artemis Koukounari, an accomplished statistician and associate director in real-world evidence at Novartis, join me for an insightful conversation. Join us as we explore these questions and more, unraveling the complexities of real-world evidence and offering a glimpse into the future of data research in the pharmaceutical realm. We also discuss the following key points:

Commentary by Dr. Candice Silversides

Sepsis‐associated acute kidney injury (SA‐AKI) is a common, increasingly prevalent problem in the intensive care unit (ICU). The association between sepsis and AKI has been studied previously. However, the lack of a reproducible and standardized consensus definition has limited the interpretability of available knowledge. In order to assess SA-AKI incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes a multicenter, observational study was conducted. In order to know more about the study methodology and findings we have interviewed Dr White. Listen to the interview in the following podcast.

Dr. Don and Professor Ben talk about the risks of using the kitchen sink to wash your hands after pooping in the bathroom. Dr. Don - not risky

About the Mini Series: This informative mini series, comprising of six episodes, is aimed at researchers intrigued by the intricacies of sedentary behavior and physical activity. It offers a comprehensive exploration into the social, emotional, and temporal contexts of these behaviors. With a special focus on understanding how such contexts are measured and their potential influence on interventions, this series serves as a vital resource for those engaged in the field of physical activity and sedentary behavior research. About the Episode Topic: Episode four dives into the diverse methodologies used for measuring the context of physical activity and sedentary behavior. The episode first elucidates the utility and limitations of conventional tools like surveys and questionnaires, shedding light on how they offer insights into individuals' perceptions, beliefs, and attitudes towards exercise and sedentary habits. It also addresses challenges like recall and social desirability bias that can influence the accuracy of the data collected through such self-report methods. Following this, the discussion transitions into observational studies, emphasizing their power to reveal patterns and associations between environmental factors and activity levels, often overlooked by self-reported methods. The episode rounds off with an exploration into the integration of technology in context measurement. It outlines the evolution of wearable devices, smartphone apps, and advanced sensors that offer real-time, objective, and continuous monitoring of physical activity and sedentary behavior. Timestamps: [00:01:00]: Introduction and Episode Overview [00:03:00]: Exploring Surveys and Questionnaires [00:05:00]: Transitioning to Observational Studies [00:07:00]: Discussing the Role of Technology in Context Measurement [00:10:00]: Introduction of Fibion Sens Motion ----------- Want to book a video call with Dr. Miriam Cabrita to discuss your sedentary behavior or physical activity measurements? Here's the link: https://olli.tucalendi.com/miriam-cabrita/videocall-miriam

This podcast discusses the connection between our thoughts and our health. Nurse Doza emphasizes the power of positive thinking and how it can lead to better health outcomes, while negative thinking can have the opposite effect. The podcast also mentions that some doctors may dismiss the importance of mental and emotional health in healing, but there are others, such as functional medicine doctors and naturopaths, who recognize this connection.   TIMESTAMPS 00:00 START 03:00 Thoughts can impact your health. 08:22 Neuroplasticity empowers our thought patterns. 14:35 Thoughts impact our physical health. 19:03 Our thoughts affect our health. 24:22 Change the radio station. 28:45 Music heals and promotes understanding. 33:51 Take care of your mindset.   Before we delve into this rich content, let's take a moment to acknowledge an important partner in our health journey - our liver. It's a silent warrior, working tirelessly behind the scenes, detoxifying our body, processing nutrients, and playing a vital role in our overall health. To aid this amazing organ, we've found the perfect ally - Liver Love from MSW. Liver Love is meticulously formulated with all-natural ingredients to support your liver function and promote detoxification. It's a powerful supplement that gives back to your liver the love and care it deserves. And here's the best part! As a valued listener of our podcast, you can enjoy an exclusive discount on your purchase. Use the code NURSEDOZA at checkout to avail of this special offer. Just visit idovitamins.com/liverlove to get your bottle of Liver Love today. By nurturing your liver, you're taking a significant step towards a healthier body and a more vibrant life. Let Liver Love be your companion on this journey, just as we are on our shared quest to understand and improve our mind-body health.   SHOW NOTES: Let's begin by acknowledging the immense power of our mindset and thoughts in shaping our health. As I converse with our clients, I consistently emphasize the crucial role our thoughts play in determining our physical well-being. The mind-body connection is profound, and today, we are going to delve deeper into it. 1. Depression as Inflammation: The link between Major Depressive Disorder (MDD), depressive symptom severity, and increased basal levels of inflammation markers such as CRP, IL-6, and IL-1 is significant^1^. Study: The Cortisol:C-reactive protein ratio and negative affect reactivity in depressed adults^1^. 2. Neuroplasticity: Neuroplasticity encompasses the adaptive structural and functional changes in the brain^1^. It involves mechanisms like neuronal regeneration, collateral sprouting, and functional reorganization^1^. The importance of improving brain plasticity is growing, particularly with the increasing rate of dementia^2^. Encouragingly, strategies that positively drive brain plasticity can lead to personal empowerment and healing^2^. Studies: Neuroplasticity^1^ and Neuroplasticity and Clinical Practice: Building Brain Power for Health^2^. 3. Positive Thoughts as Frequencies: The theta/beta ratio has been correlated with cognitive processing, while arousal markers are associated with alpha power^1^. Study: The Theta/Beta Ratio as an Index of Cognitive Processing in Adults With the Combined Type of Attention Deficit Hyperactivity Disorder^1^. 4. The Gut-Brain Connection: Serotonin plays a key role in the motoric and sensory functions of the upper gastrointestinal tract^1^. On the other hand, a low vagal tone, a marker of the sympatho-vagal balance, is observed in functional digestive disorders and inflammatory bowel diseases^3^. Studies: Serotonin in the Gut: What Does It Do?^1^, Serotonergic signalling in the stomach and duodenum of patients with gastroparesis^2^, and Vagal tone: effects on sensitivity, motility, and inflammation^3^. 5. Sound as Healing: Tibetan singing bowl meditation can significantly reduce feelings of tension, anxiety, and depression while increasing spiritual well-being^1^. Music, especially low-frequency sound stimulation, has been shown to reduce pain perception and affect the release of neurotransmitters and hormones^2^. Studies: Effects of Singing Bowl Sound Meditation on Mood, Tension, and Well-being: An Observational Study^1^ and The effect of low-frequency sound stimulation on patients with fibromyalgia: A clinical study^2^. This mental-physical health nexus we've explored today underscores the need for a holistic approach to wellness, where mind and body are treated as interconnected entities. Let's continue this enlightening journey together, shaping a healthier, happier you.

The COVID-19 pandemic and associated public health measures shifted the way people access health care. In this podcast, Dr. Christine Leong, Associate Professor at the University of Manitoba College of Pharmacy, discusses the research she and her colleagues conducted to study the effects of the pandemic on psychotropic medication adherence. The data were drawn from a claims repository that contains information on health service and medication use for almost all Manitoba residents. The study showed improved adherence to most psychotropic medications in the 9 months after public health restrictions were enacted. Patients who were already adherent to their psychotropic medications were less likely to discontinue them during the pandemic. Findings in this study highlight that, although there were concerns about public health measures restricting access to in-person care, access to medications in Manitoba did not seem to be restricted. The article “Adherence to Psychotropic Medication Before and During COVID-19: A Population-Wide Retrospective Observational Study” is published in the July-August 2023 issue of the Journal of Clinical Psychopharmacology.

The anticipated conclusion to the two part series on ultra-processed food. In this episode Dr. Pamela Hutchison will share practical strategies to identify these tasty foods and understand their impact on your health. If you missed the first episode of this podcast series download season 1 episode 8. It's the perfect starting point for your quest toward a more informed and conscious approach to ultra-processed foods. In today's episode we'll discuss: Briefly review what are ultra-processed foods Why ultra-processed foods are so delicious Some tools and tips to identify, avoid and understand the impact of these foods in our diets. Connect with me: Pamela's Instagram: https://www.instagram.com/dr_pamela_hutchison_nd The Well Nurtured Brain's Instagram: https://www.instagram.com/the_well_nurtured_brain/ Facebook: https://www.facebook.com/profile.php?id=100089475401521&mibextid=LQQJ4d Website: www.TheWellNurturedBrain.com Email: thewellnurturedbrain@gmail.com   Episode References:  https://news.ku.edu/2023/01/30/research-shows-impact-hyper-palatable-foods-across-four-diets#:~:text=First%20described%20by%20KU%20scientist,and%20harder%20to%20stop%20consuming Fazzino, T.L., Courville, A.B., Guo, J. et al. Ad libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns. Nat Food 4, 144–147 (2023). https://doi.org/10.1038/s43016-022-00688-4 Fazzino, T.L., Rohde, K. and Sullivan, D.K. (2019), Hyper-Palatable Foods: Development of a Quantitative Definition and Application to the US Food System Database. Obesity, 27: 1761-1768. https://doi.org/10.1002/oby.22639 Gearhardt, AN, DiFeliceantonio, AG. Highly processed foods can be considered addictive substances based on established scientific criteria. Addiction. 2023; 118( 4): 589– 598. https://doi.org/10.1111/add.16065 https://shows.acast.com/5eaeb1c98ad11b317bf47794/6388f4091af4a90011ec7e1e Monteiro, C., Cannon, G., Levy, R., Moubarac, J., Louzada, M., Rauber, F., . . . Jaime, P. (2019). Ultra-processed foods: What they are and how to identify them. Public Health Nutrition, 22(5), 936-941. doi:10.1017/S1368980018003762 Studies cited or used as resources for episode Tian, Y. R., Deng, C. Y., Xie, H. C., Long, Q. J., Yao, Y., Deng, Y., Zhao, H., Li, Y., Liu, H., & Xiao, L. (2023). Ultra-processed food intake and risk of depression: a systematic review. Ingestión de alimentos ultraprocesados y riesgo de depresión: revisión sistemática. Nutricion hospitalaria, 40(1), 160–176. https://doi.org/10.20960/nh.03723 Lane, M. M., Gamage, E., Travica, N., Dissanayaka, T., Ashtree, D. N., Gauci, S., Lotfaliany, M., O'Neil, A., Jacka, F. N., & Marx, W. (2022). Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 14(13), 2568. https://doi.org/10.3390/nu14132568 Gomes Gonçalves, N., Vidal Ferreira, N., Khandpur, N., Martinez Steele, E., Bertazzi Levy, R., Andrade Lotufo, P., Bensenor, I. M., Caramelli, P., Alvim de Matos, S. M., Marchioni, D. M., & Suemoto, C. K. (2023). Association Between Consumption of Ultraprocessed Foods and Cognitive Decline. JAMA neurology, 80(2), 142–150. https://doi.org/10.1001/jamaneurol.2022.4397 Additional resources Resources: NOVA Classification Reference Sheet PDF

Commentary by Dr. Candice Silversides

Chad Harman is a leading figure in the field of mental health treatments using psychedelic medicines. He is the driving force behind a bioscience company that is focused on developing precise and targeted dosing control technologies for psychedelics. With years of experience in the industry, Chad has identified the primary issues that need to be addressed, such as the side effects that can arise from using such powerful medicines. He is dedicated to bringing these technologies through the FDA clinical trial pathway, and he is committed to making mental health treatments more effective and accessible to patients who need them.

How do you identify postinfection irritable bowel syndrome? How long will it last and how do you treat it? Join expert physicians Lin Chang and Madhu Grover as they discuss. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987260). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Post-Infection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34024451/ Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery https://pubmed.ncbi.nlm.nih.gov/16890598/ Sex-Gender Differences in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/30347934/ Prevalence of Gastrointestinal Symptoms Six Months After Bacterial Gastroenteritis and Risk Factors for Development of the Irritable Bowel Syndrome: Postal Survey of Patients https://pubmed.ncbi.nlm.nih.gov/9080994/ The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/21256129/ Randomised Placebo-Controlled Trial of Dietary Glutamine Supplements for Postinfectious Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/30108163/ Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36858143/ Double-blind Placebo-Controlled Study of Mesalamine in Post-Infective Irritable Bowel Syndrome – A Pilot Study https://pubmed.ncbi.nlm.nih.gov/22783919/ Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/28846594/ The COVID-19 Pandemic and Post-Infection Irritable Bowel Syndrome: What Lies Ahead for Gastroenterologists https://pubmed.ncbi.nlm.nih.gov/35944588/ The Prevalence of Irritable Bowel Syndrome After Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Their Association: A Systematic Review and Meta-Analysis of Observational Studies https://pubmed.ncbi.nlm.nih.gov/36902651/ Postinfection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34789582/ COVID-19 as a Trigger of Irritable Bowel Syndrome: A Review of Potential Mechanisms https://pubmed.ncbi.nlm.nih.gov/34887641/ Incidence and Predisposing Factors for De Novo Post-COVID-19 Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36468570/ Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/32916129/ Serine Proteases as Luminal Mediators of Intestinal Barrier Dysfunction and Symptom Severity in IBS https://pubmed.ncbi.nlm.nih.gov/30923071/ Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy https://pubmed.ncbi.nlm.nih.gov/28274108/ Performance and Interpretation of Hydrogen and Methane Breath Testing Impact of North American Consensus Guidelines https://pubmed.ncbi.nlm.nih.gov/35366119/

In part one of this two part series of the Well Nurtured Brain, Dr. Pamela Hutchison will dive into the intriguing relationship between ultra-processed foods and the intricate workings of our brain. She will share the research related to these processed delights and shed some light on the potential links to neurodegenerative disorders and mental health conditions. Stay tuned for the second instalment of this series on May 30th where Dr. Pamela will share how to identify these foods.  In today's episode we'll discuss: The Nova Food Classification system Ultra-processed foods and depression A study that examined cognitive decline in relation to ultra-processed foods Studies cited or used as resources for episode Tian, Y. R., Deng, C. Y., Xie, H. C., Long, Q. J., Yao, Y., Deng, Y., Zhao, H., Li, Y., Liu, H., & Xiao, L. (2023). Ultra-processed food intake and risk of depression: a systematic review. Ingestión de alimentos ultraprocesados y riesgo de depresión: revisión sistemática. Nutricion hospitalaria, 40(1), 160–176. https://doi.org/10.20960/nh.03723 Lane, M. M., Gamage, E., Travica, N., Dissanayaka, T., Ashtree, D. N., Gauci, S., Lotfaliany, M., O'Neil, A., Jacka, F. N., & Marx, W. (2022). Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 14(13), 2568. https://doi.org/10.3390/nu14132568 Gomes Gonçalves, N., Vidal Ferreira, N., Khandpur, N., Martinez Steele, E., Bertazzi Levy, R., Andrade Lotufo, P., Bensenor, I. M., Caramelli, P., Alvim de Matos, S. M., Marchioni, D. M., & Suemoto, C. K. (2023). Association Between Consumption of Ultraprocessed Foods and Cognitive Decline. JAMA neurology, 80(2), 142–150. https://doi.org/10.1001/jamaneurol.2022.4397   Additional resources Resources: NOVA Classification Reference Sheet PDF   Connect with me: Pamela's Instagram: https://www.instagram.com/dr_pamela_hutchison_nd The Well Nurtured Brain's Instagram: https://www.instagram.com/the_well_nurtured_brain/ Facebook: https://www.facebook.com/profile.php?id=100089475401521&mibextid=LQQJ4d Website: www.TheWellNurturedBrain.com Email: thewellnurturedbrain@gmail.com

Drs. Russell Rothman and Erin Holve discuss a decade of research in PCORnet®.

Have you been considering a one-armed observational study?  As a statistician, it is important to understand the various types of studies that are used in data gathering. In this episode, we will be discussing one-armed observational studies and why they are, in most cases, not a good idea. We will also touch on the early days of my career as a statistician and how I initially approached one-armed observational studies. We also discuss the reputation problems of these studies and the scientific problems such as:

In this episode, Donovan & Matt speak with Geoffrey Hoffman, a faculty member and researcher at the University of Michigan School of Nursing. Dr. Hoffman discusses the transition to the role of caregiver for partners of persons diagnosed with dementia – and the unique emotional burden and stress that they undertake. Dr. Hoffman also discusses using the Health & Retirement Study (HRS) to better explore the emotional stress and onset of depression in caregivers. Geoff Hoffman Faculty Profile: https://nursing.umich.edu/faculty-staff/faculty/geoffrey-j-hoffman Article Referenced in this Episode Harris ML, Errickson J, Ha J, Hoffman GJ. Depressive Symptoms and Caregiving Intensity Before and After Onset of Dementia in Partners: A Retrospective, Observational Study. Med Care. 2022;60(11):844-851. doi:10.1097/MLR.0000000000001771 [PMID: 36038513] The transcript for this episode can be found here.CAPRA Website: http://capra.med.umich.edu/ You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

Dr. Pensa interviews Dr. Brittany Ellis about a new paper in AEM Journal. 

Real Life Reserve: Hip FX Case  #oldnotweak #mmoa #icetrained #physicaltherapy #occupationaltheraoy #dpt #otr #physiotherapy #fitness #geriatrics #balance #falls Panula, J., Pihlajamäki, H., Mattila, V.M. et al. Mortality and cause of death in hip fracture patients aged 65 or older - a population-based study. BMC Musculoskelet Disord 12, 105 (2011). https://doi.org/10.1186/1471-2474-12-105 Tang VL, Sudore R, Cenzer IS, Boscardin WJ, Smith A, Ritchie C, Wallhagen M, Finlayson E, Petrillo L, Covinsky K. Rates of Recovery to Pre-Fracture Function in Older Persons with Hip Fracture: an Observational Study. J Gen Intern Med. 2017 Feb;32(2):153-158. doi: 10.1007/s11606-016-3848-2. Epub 2016 Sep 7. PMID: 27605004; PMCID: PMC5264672. Want to make sure you stay on top of all things geriatrics? Go to https://MMOA.online to check out our Free eBooks, Lectures, & the MMOA Digest!

On this episode of WOCTalk, we sit down with Renee Malandrino, MSN, RN, CWOCN, Margaret Goldberg, MSN, RN, CWOCN, and Lisa Peacey, BSN, RN, NSWOC, three of the authors of the WOCNext® 2022 ePoster, “Patient Reported Outcomes on Living with an Ostomy: Reporting on Three Years of Data.” Renee, Margaret, and Lisa discuss the Observational Study of Ostomy Consumers (OSO™) registry, the registry collection tools, and their thoughts on the current OSO registry survey results. The OSO registry provides an opportunity to collect prospective, observational, patient-reported outcomes data and explore the experiences of living with an ostomy over a 5-year period. This information will aid in directing future research to support or challenge current knowledge and therefore guide future clinical practice, clinical research, and new product innovations.This podcast episode is supported by an educational grant from Hollister Incorporated. The WOCN® Society does not endorse specific products and services. Episode Resources:Click here to read the Wound Management & Prevention Original Research article, “Methods and Initial Findings of the Observational Study of Ostomy Consumers Registry”Click here to visit the online Hollister Product selectorClick here to view the WOCNext 2022 abstract, “Patient Reported Outcomes on Living with an Ostomy: Reporting on Three Years of Data.”Click here to view the interactive ePoster and author video from WOCNext 2022Click here to view all WOCNext 2022 accepted abstracts and ePostersClick here to view the Peristomal Skin Assessment Guide for CliniciansClick here to view the Peristomal Skin Assessment Guide for Consumers (English)  Click here to view the Peristomal Skin Assessment Guide for Consumers (Spanish)  

Happy New Year! This month we've got a New in EM looking at the use of neutrophil-lymphocyte ratios in septic arthritis and a discussion on specificity vs. sensitivity. Becky and Chris look at the new NICE guidance on subarachnoid haemorrhage and Rob talks for too long about it, and then we return to New Online with some new articles for your CPD. If you'd like to email us, please feel free to do so here. here. (02:38) New in EM – Neutrophil:lymphocyte ratio in septic arthritis - Synovial Fluid and Serum Neutrophil-to-Lymphocyte Ratio Novel Biomarkers for the Diagnosis and Prognosis of Native Septic Arthritis in Adults (14:49) Guidelines for EM – NICE Guidance on the diagnosis and management of subarachnoid haemorrhage NICE NG228 - Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management An Observational Study of 2,248 Patients Presenting With Headache, Suggestive of Subarachnoid Hemorrhage, Who Received Lumbar Punctures Following Normal Computed Tomography of the Head - Sayer et al. (2015) Prospective Implementation of the Ottawa Subarachnoid Hemorrhage Rule and 6-Hour Computed Tomography Rule - Perry et al. (2020) An international study of emergency physicians' practice for acute headache management and the need for a clinical decision rule - Perry et al. (2009) The SHED Study - TERN (56:21) New Online – new articles on RCEMLearning for your CPD GAS, iGAS and Scarlet Fever – Nikki Abela Agents of Change – Public Health in ED – Ines Corcuera and Michelle Ryan

Isolated Weber B, AO (Association for the Study of Internal Fixation) type 44B ankle fractures with no fracture to the medial side are the most common type of ankle fracture and may be treated with internal fixation or without surgery.   This study aimed to determine if surgery is superior to nonsurgical management for the treatment of these fractures after a minimum 5-year follow-up.   In conclusion, the results of this study suggest that in terms of patient-reported outcomes, surgical management is not superior to nonsurgical management in type B ankle (fibula) fractures with minimal talar shift over a 5-year period and that surgery is associated with increased adverse events.   To view the article, click here.

How could differences between countries affect the elements that are included in statistical research? How could studies with such a diverse sample from different countries be managed to create a more dependable reference for statistical studies? How do differences of the quality of care that the target population receives impact studies? As statisticians, we need to be able to understand the validity of the outcomes of statistical analysis for different target populations. In this podcast, you will learn ways to tackle this problem: In this podcast, you will learn how this problem could be resolved:

In Episode 8 of Heal Yourself with the Law of Attraction, we are continuing with our POWER series. In this episode, we will cover the following topics:What is sound healing or music healing.What instruments are leveraged in sound healing.How sound healing relates to the Law of Attraction.The science behind sound healing or sound therapy.Mental and physical health benefits of sound healing.My personal experience with sound healing.Steps you can take to benefit from sound healing.Helpful Linkshttps://open.spotify.com/album/5xhJnxqpZ2xScrX1VerZIV?si=S3FE3xt7QYObX7Hm2lq3lwhttps://open.spotify.com/playlist/3oVlsqPd8M4oFUImLoacaY?si=86a3260913ab46b3https://open.spotify.com/playlist/1XwKUWMdmA58nlu8REVUUP?si=788b38948ef44b30ReferencesGoldsby TL, Goldsby ME, McWalters M, Mills PJ. Effects of Singing Bowl Sound Meditation on Mood, Tension, and Well-being: An Observational Study. J Evid Based Complementary Altern Med. 2017 Jul;22(3):401-406. doi: 10.1177/2156587216668109. Epub 2016 Sep 30. PMID: 27694559; PMCID: PMC5871151.Merz, B. (2015, November 5). Healing through music. Harvard Health. https://www.health.harvard.edu/blog/healing-through-music-201511058556.Hurst, K. (2022, July 15). Sound Healing: The Benefits of Healing Frequencies & Music. The Law of Attraction. https://thelawofattraction.com/sound-healing/.

Observational studies are designed to establish baseline data for diseases and treatments across broad patient populations. There are over 94,000 of them each year. Often, these studies go on for an extended period of time, which places challenges on study sponsors to keep participants engaged and motivated. In this episode, Greg Kefer talks with Rob Chipperfield, a clinical study executive who has spent over a decade helping the world's leading research organizations design and operationalize real world studies. Digital engagement is the key to ensuring participants follow the protocols, provide feedback and not drop out. Mobile technology is vital, but study designers look for was to keep things very simple so participants stay engaged for the duration of the study. The low friction nature of Conversational AI may prove to be the ideal approach to keeping communication channels going through the duration of the study.

In this episode of Research Review on the Blair Technique Podcast, we break down the recent publication titled Secretory Immunoglobulin A and Upper Cervical Chiropractic: A Preliminary Prospective, Multicenter, Observational Study. As a lead researcher and co-author on this paper, Dr. Schurger discusses the rationale behind the study, challenges and limitations of the study, clinical implications in today's healthcare climate, and the process of getting a paper like this into publication. Download the article for yourself here: Full Text PDF Download To learn more about the ICA Council on Upper Cervical care, visit https://www.icauppercervical.com/ Check out upcoming events including seminars with Dr. Schurger on the events calendar at https://www.blairtechnique.com/ To find a qualified Blair Upper Cervical Chiropractor near you, visit https://www.blairchiropractic.com/ Connect with Dr. Schurger at https://keystonechirospi.com/

How legitimate is the common corporate criticism of the scientific nutrition literature that the credibility of observational studies is questionable?

In this episode, Marc and Mo are joined by special guest Gerard Slobogean, MD (Associate Professor and Director of Clinical Research, Department of Orthopaedics, University of Maryland School of Medicine) in an insightful conversation on the current issues and challenges related to the treatment of, and research into, open fractures. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: Chang Y, Bhandari M, Zhu KL, Mirza RD, Ren M, Kennedy SA, Negm A, Bhatnagar N, Naji FN, Milovanovic L, Fei Y, Agarwal A, Kamran R, Cho SM, Schandelmaier S, Wang L, Jin L, Hu S, Zhao Y, Lopes LC, Wang M, Petrisor B, Ristevski B, Siemieniuk RAC, Guyatt GH. Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations. JBJS Rev. 2019 Feb;7(2):e1. doi: 10.2106/JBJS.RVW.17.00197. PMID: 30724762. https://jbjs.org/reader.php?id=205004&rsuite_id=1938010&native=1&source=JBJS_Reviews/7/2/e1/abstract&topics=ta#info Foote CJ, Tornetta P 3rd, Reito A, Al-Hourani K, Schenker M, Bosse M, Coles CP, Bozzo A, Furey A, Leighton R; GOLIATH Investigators. A Reevaluation of the Risk of Infection Based on Time to Debridement in Open Fractures: Results of the GOLIATH Meta-Analysis of Observational Studies and Limited Trial Data. J Bone Joint Surg Am. 2021 Feb 3;103(3):265-273. doi: 10.2106/JBJS.20.01103. Erratum in: J Bone Joint Surg Am. 2021 Mar 17;103(6):e25. PMID: 33298796. https://www.jbjs.org/reader.php?id=207441&rsuite_id=2681010&native=1&topics=ta&source=The_Journal_of_Bone_and_Joint_Surgery%2F103%2F3%2F265%2Ffulltext#content/contributor_reference_11 PREP-IT Trial: https://www.prepittrial.com/ Stennett CA, O'Hara NN, Sprague S, Petrisor B, Jeray KJ, Leekha S, Yimgang DP, Joshi M, O'Toole RV, Bhandari M, Slobogean GP; FLOW Investigators. Effect of Extended Prophylactic Antibiotic Duration in the Treatment of Open Fracture Wounds Differs by Level of Contamination. J Orthop Trauma. 2020 Mar;34(3):113-120. doi: 10.1097/BOT.0000000000001715. PMID: 32084088; PMCID: PMC8077225. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077225/