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Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Most people assume that if a drug sits on the shelf at Costco or Walgreens, it must be pretty safe. But what if some of the most common over-the-counter (OTC) medications are among the riskiest drugs in America? On this vintage episode of Vitality Radio, Jared exposes the hidden dangers behind everyday pain relievers, sleep aids, and heartburn drugs—medicines that cause thousands of deaths every year when misused or taken long-term. You'll learn how a drug becomes “OTC,” what happens when pharmaceutical companies push for that switch, and why the FDA's approval process might not tell the whole story. Jared dives into the startling realities of PPIs like Prilosec, NSAIDs like ibuprofen, and acetaminophen (Tylenol)—uncovering their risks to the liver, kidneys, bones, and brain. He also discusses how marketing convinces consumers these drugs are harmless. Finally, Jared offers a resource for safe, natural alternatives for reflux, pain, inflammation, sleep, and immune support—options that nourish the body instead of depleting it. This episode will change the way you look at “harmless” OTC drugs and help you take real control of your health.Additional Information:#341: Your Digestive Health Supplement User's Guide. From IBS to Acid Reflux - Learn How to Balance Your Gut Health With Natural Products. #522: Q&A Show #5 - Jared Answers Your Questions About Energy and Sleep!#471: Boosting Your Immune System Ahead of Winter #553: Boswellia & Curcumin: Nature's Dream Team for Pain & Inflammation with Dr. Lexi LochVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Ibuprofen, acetaminophen and aspirin — there are many over-the-counter pain medications available, but are they all the same? And how much should you really take? In this episode, pharmacists and a doctor cover your drug options, including side effects, dosage and what to reach for the next time you have a headache or fever. This episode was originally published on March 31, 2025.Follow us on Instagram: @nprlifekitSign up for our newsletter here.Have an episode idea or feedback you want to share? Email us at lifekit@npr.orgSupport the show and listen to it sponsor-free by signing up for Life Kit+ at plus.npr.org/lifekitSee pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.NPR Privacy Policy

Ibuprofen, acetaminophen and aspirin — there are many over-the-counter pain medications available, but are they all the same? And how much should you really take? In this episode, pharmacists and a doctor cover your drug options, including side effects, dosage and what to reach for the next time you have a headache or fever. This episode was originally published on March 31, 2025.Follow us on Instagram: @nprlifekitSign up for our newsletter here.Have an episode idea or feedback you want to share? Email us at lifekit@npr.orgSupport the show and listen to it sponsor-free by signing up for Life Kit+ at plus.npr.org/lifekitSee pcm.adswizz.com for information about our collection and use of personal data for sponsorship and to manage your podcast sponsorship preferences.NPR Privacy Policy

Part 2 of our interview with the Finnish artist and writer Jaakko Pallasvuo, author most recently of Amber (Rrose Editions, 2026) and Mouthing the Words (Khaos, 2025) Hosted on Acast. See acast.com/privacy for more information.

Wenn du keine Ibu 800 bekommst, nimm halt zwei 400er! So einfach die Rechnung und die üblichen Tipps. Klingt auch logisch! Aber ist es wirklich so einfach?

Jaakko Pallasvuo is a Helsinki-based artist and writer, best known for his Instagram account Avocado Ibuprofen. In this episode he reflects on the role he sees for art and writing in a world increasingly shaped by social media platforms and artificial intelligence, and he discusses his recently published collection of performance texts Mouthing the Words (Khaos, 2025).Scaffold is an Architecture Foundation production, hosted by Matthew Blunderfield. Download the London Architecture Guide App via the App Store or Google PlayBecome an Architecture Foundation Patreon member and be a part of a growing coalition of architects and built environment professionals supporting our vital and independent work. Hosted on Acast. See acast.com/privacy for more information.

Wann helfen Ibuprofen oder Paracetamol wirklich und wann wird es riskant? Dr. Frank Schäfer erklärt, worauf du bei Schmerzmitteln achten solltest.

Pope Leo XIV's first Easter message, where he called for global peace amidst conflicts like the Russia-Ukraine war and the US-Israeli war on Iran. The "messy" irony lies in the transition from a solemn papal address on world "ravaged by wars" to the interpersonal "messiness" and psychological pathology discussed in the following segments.   The Anti-Inflammatory Power of Basil Basil contains a high concentration of Eugenol. In the world of natural chemistry, Eugenol is a "blocker"—it actually works similarly to over-the-counter NSAIDs (like Ibuprofen) by inhibiting the enzymes (COX-2) that cause swelling and pain in the joint. How it adds to your Aloe-Herb Salve: Adding Basil creates a "Triple Threat" for your severe arthritis: Rosemary: Increases local circulation (brings blood flow to the joint). Lemon Balm: Calms the "angry" sensory nerves around the kneecap. Basil: Acts as the heavy-duty anti-inflammatory to reduce the actual swelling. Savoring the Silence & Protecting the Peace. You can't fix stupid, and you certainly can't fix a narcissist. But you can fix your boundaries. If every time you share a win, you get a grunt, stop sharing the win. Build your 'Silent Resort' and invite people who know how to celebrate. Your joy is too expensive to be spent on someone who is committed to being miserable. Protect that peace! Federation is a hard sci-fi crossover; it functions as a secular Passion play. It tells the story of a man (Cochrane) who suffers through a global apocalypse (WWIII), offers humanity "salvation" through the light of warp drive, disappears (dies to the world), and is ultimately "resurrected" through the grace of an alien entity and the legacy he leaves behind. The Bravo-verse: A Masterclass in Internalized Bias & Bozoma St. John, Gamer Recognized Game. I don't think I am kissing up, I am calling a spade a spade. And Boz St. John is calling 4-a possible- 5, yelling Domino, Uno Reverse-draw 4-Uno on those b@@@chs.      Just when I thought I was going to leave Reality TV commentary to the pros, here comes Ciara Miller and The Boz of it all....While the underfed hippos are snapping in the fake LA swamp, Bozoma is playing the Kobayashi Maru of the C-Suite. She didn't come to win the game; she came to audit the players and then unplug the board. Checkmate. Meeting Adjourned.   Check out my music on Spotify and Apple or wherever you listen to music! The official videos are on YouTube. Stream and stream often! Navigate to https://linktr.ee/tnfroisreading to check out all coffee and book options. Seasonal Affective Disorder Is Treatable and all of us should be about fixing our mental health always.... If you are searching for help and direction in your struggles with depression and addiction Call 1-800-273-8255 Available 24 hours everyday   There is also an online chat feature https://suicidepreventionlifeline.org/chat/   And if Vodka is the problem, call  1-800-662-HELP (4357) for 24/7 help. Please reach out to find joy in this season!

This month for the March 2026 episode of the RCEM Learning Podcast Andy and Dave discuss ibuprofen and additional opiates in paediatric injury. Becky and Chris talk through an RCEM Best Practice Guideline on the management of sexual assault in the ED and Rob then talks with one of the authors, Maddy Dodds, about this guideline. As a TRIGGER WARNING, this does involve discussion around the topic of sexual assault. If you'd like to email us, please feel free to do so here. After listening, complete a short quiz to have your time accredited for CPD at the RCEMLearning website! (02:35) New in EM - Ibuprofen and additional opiates in paediatric injury Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children's Musculoskeletal Injury: Two Randomized Clinical Trials (Ali et al., 2026) (19:15) Guidelines for EM - RCEM Best Practice Guideline for the Management of Sexual Assault in the ED RCEM Best Practice Guideline for the Management of Sexual Assault in the ED (2026) [PDF] (49:36) Sexual assault in the ED - Maddy Dodds RCEM Best Practice Guideline for the Management of Sexual Assault in the ED (2026) [PDF] Become a paid QI Fellow at RCEM - act now! RCEM Quality Fellow Job Description [Word]

On this episode of Vitality Radio, Jared shares his personal approach to natural pain relief after a season of bumps, strains, sore feet, and everyday aches. Instead of relying on NSAIDs, he walks through the natural tools he keeps on hand—including homeopathic T-Relief, curcumin formulas, PEA, CBD, magnesium, and targeted nutrients for nerve and joint support. Jared explains how different types of discomfort—such as bruises, nerve irritation, or joint stiffness—may benefit from different strategies and why experimentation is often key to finding what works best for your body. He also discusses collagen, bone broth protein, and joint lubrication support for long-term mobility, plus a cleaner topical lidocaine option for short-term relief. The goal isn't just masking discomfort—it's building a natural toolkit that supports resilience, recovery, and everyday movement.Products:MediNatura Pain ProductsCuraMed Acute PainPEACBD Products - Call us to order! 801-292-6662BenfotiamineAlpha Lipoic AcidNerve ReverseBaxylMagnesium BisglycinateMagnesium LotionRebuild+ Functional Bone Broth ProteinAdditional Information:#622: Natural Pain Relief: Homeopathy, Arnica, and a Cleaner Approach to Lidocaine with Marie Camille#620: CBD, THC, and Hemp: How to Use Them Wisely for Sleep, Stress, and Pain#472: Could LDN Be Your Answer For Autoimmune Disease? With Dr. Keith BerkowitzVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Schmerzmittel gehören für viele zum Alltag – ob bei Kopfschmerzen, Rückenschmerzen oder nach einer Operation. In dieser Folge von „Aha! Zehn Minuten Alltagswissen“ erklären wir, wie Wirkstoffe wie Ibuprofen, Paracetamol oder Aspirin im Körper wirken, worin sie sich unterscheiden und ab wann ihre Einnahme problematisch werden kann. Zu Gast ist der Schmerzmediziner Dr. Andreas Böger vom Schmerzzentrum Kassel. Im zweiten Teil des Podcasts geht es um eine psychologische Frage: Warum merken wir uns Kritik oft stärker als Lob? REDAKTIONELLER HINWEIS: In einer früheren Version dieser Folge wurde fälschlicherweise gesagt, Paracetamol gehöre zur Gruppe der nichtsteroidalen Antirheumatika, also der NSAR. Das ist nicht korrekt. Wir bitten, das zu entschuldigen! "Aha! Zehn Minuten Alltags-Wissen" ist der Wissenschafts-Podcast von WELT. Wir freuen uns über Feedback an wissen@welt.de. Produktion: Sermet Agartan Redaktion: Fiona Wink Impressum: https://www.welt.de/services/article7893735/Impressum.html https://www.welt.de/services/article157550705/Datenschutzerklaerung-WELT-DIGITAL.html

Three studies highlight new findings: A phase 3 trial showed obinutuzumab significantly improved lupus responses versus placebo in active SLE patients on standard therapy. A trial of finerenone in type 1 diabetes with chronic kidney disease demonstrated meaningful reductions in albuminuria compared to placebo, suggesting a new renal-protective option. Finally, paired pediatric trials found that adding acetaminophen or hydromorphone to ibuprofen provided no additional pain relief for children's acute limb injuries, with opioids causing four times more adverse events. Ibuprofen alone remains the recommended first-line approach.

Warum werden ausgerechnet die Menschen häufiger krank, die am meisten für ihre Gesundheit tun? Das Immunsystem-Paradox: Zu wenig Sport schwächt die Abwehr – aber zu viel Sport auch.Dr. med. Elke Mantwill ist Fachärztin für Allgemeinmedizin, Sportmedizin und Ernährungsmedizin, Diplom-Sportwissenschaftlerin – und selbst mehrfache Ironman-Finisherin. Sie kennt das Dilemma aus beiden Perspektiven: Als Ärztin behandelt sie täglich ambitionierte Sportler, die nicht verstehen, warum sie ständig erkältet sind. Und als Athletin hat sie am eigenen Leib erlebt, was passiert, wenn man die Grenzen seines Körpers testet.Du erfährst:Warum Dein Immunsystem nach intensivem Training ein „Open Window“ öffnet – und was Du dagegen tun kannstUm welche Nährstoffe Deine Muskeln und Dein Immunsystem gleichzeitig kämpfen (und wie Du den Konflikt löst)Die „Number Needed to Treat“: Warum Bewegung 500× effektiver ist als MedikamenteWarum 70 % Deines Immunsystems im Darm sitzen – und was Ibuprofen damit anrichtetElkes Top-3-Sofortmaßnahmen für alle, die häufiger erkältet sind als früherWie Du ambitioniert trainieren kannst, ohne Deine Gesundheit zu opfernViel Spaß beim Zuhören!____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________Alle Shownotes zur Folge auf marathonfitness.de.Zeitmarken[05:20] Begrüßung: Training heute Morgen[05:28] Elkes eigene Erfahrung: Wann der Körper „Stopp“ sagt[08:33] Die häufigsten Gründe für Praxisbesuche[11:23] Das Paradox: Warum zu viel UND zu wenig Sport krank macht[14:56] Woran erkenne ich, ob mein Training zu intensiv ist?[18:48] HRV und Schlaftracker: Was sie wirklich aussagen[20:32] Bewegungsmangel: Die unterschätzte Todesursache[22:51] Der Energiekonflikt: Gehirn, Immunsystem, Muskeln[28:04] Metapher: Der Körper als Unternehmen mit begrenztem Budget[29:40] Welche Mikronährstoffe beim Sport am schnellsten verloren gehen[34:25] Was Mikronährstoffmangel mit dem Immunsystem macht[36:15] Fallstudie: Die 55-jährige Managerin[43:41] Das Open Window: Was nach dem Training passiert[46:10] Die Post-Workout-Immunsystem-Routine[46:55] Myokine: Wenn Muskeln mit dem Immunsystem kommunizieren[48:00] Stress addiert sich: Job + Training = ?[52:15] Der Darm: 70 % des Immunsystems sitzen hier[53:36] Was Elke im Mikrobiom von Sportlern findet[54:43] Leaky Gut: Pseudowissenschaft oder echtes Problem?[58:34] Warum Ibuprofen oft kontraproduktiv ist[01:00:56] Parasiten: Das Tabuthema[01:04:46] Top 3 Sofortmaßnahmen bei Infektanfälligkeit[01:08:13] Training anpassen: Weniger Intensität oder besser periodisieren?[01:09:45] Perfektionismus: Das eigentliche Problem?[01:15:10] Elkes großes Ziel: Ironman Roth[01:17:59] Hausmittel: Ingwer, Knoblauch, Manuka-Honig[01:19:06] Grenzfall: Leicht erkältet trainieren?[01:20:26] Nach Erkrankung: Wie lange warten?[01:21:35] Was sich in 25 Jahren verändert hat[01:22:33] Elkes Bücher[01:23:16] Die Smartphone-Nachricht____________Shownotes und Übersicht aller Folgen.Trag Dich in Marks Dranbleiber Newsletter ein.Entdecke Marks Bücher.Folge Mark auf Instagram, Facebook, Strava, LinkedIn. Hosted on Acast. See acast.com/privacy for more information.

Ibuprofen, I choose you! 30 years of Pokémon, can you believe it? Our knees sure can. The Pokemon Day Presents brought us our first look at Gen 10, Winds and Waves. We prepare for what will be Joelle's first foray into the series with Pokopia, and Leah gives her thoughts on Dredge. Plus, since we're in a birthday type of mood, we play a round of Guess That Game's Anniversary! What is Everyone Playing? (00:22:10) Dredge (00:32:12) Pokémon Leaf Green and Fire Red (00:39:10) Game On: Guess That Game's Anniversary! (00:39:13) This Week's News: Pokémon Day Presents (00:48:40) Pokémon Day Presents 2026 Round-Up Outro and Wrap-up (01:10:35) --- Thanks for listening! The GoGCast comes out weekly so make sure to subscribe and you won't miss an episode. For more about us, Girls on Games, check out girlsongames.ca. Buy us a Ko-Fi at https://ko-fi.com/girlsongames

A Knee Recovery Nightmare! Right Total Knee Replacement My Physical and Emotional Fight Against Pain Hypersensitivity and Protective Muscle Guarding – written by Cathy Banovac – interview by Lisa Pelley and Mary Elliott – Cathy was coached by Erin Rempher, PTA My name is Cathy and I reside in Arizona. I am 57 years old, a homemaker, and have had a genetic history of chronic osteoarthritis.  From a very young age, I have always had a very low pain threshold.  Prior to the commencement of pain in my knee, I considered myself a fairly fit and active person…loved gardening, entertaining family and friends, cooking, crafting, playing golf, traveling with my husband, walking our dogs, and playing with our grandchildren. Life was good! Early Summer In addition to the normal aches and pains that come with aging, I began to experience more than usual pain in my right knee.  I was experiencing daily occurrences of popping/clicking, giving out when walking at times, difficulty negotiating steps or stairs, and nightly interrupted sleep due to pain.  Over the counter medications, icing, heat, etc. was no longer managing my symptoms.  Upon visiting an orthopedic surgeon for examination and subsequent imaging, I learned I was over 70% bone on bone in my right knee joint.  I was told I was looking at a total knee replacement.  I was preparing to head to Michigan for a family vacation on the lake with my kiddos in August, so was not happy to hear this news.  I convinced my doctor to give me a steroid injection just to buy me the time I needed to take my vacation.  He was reluctant and told me that he predicted it would do nothing to help my condition at the very least or, at the very most, last for a brief time.  I made it through the trip, yet 3 weeks post-injection the symptoms had returned. No More Injections My surgeon declined my request for another injection, instead reiterating my need for the TKR.  Over previous years, I had witnessed my mother, father, husband and a few friends have knee replacement surgeries.  All came through their surgeries with what appeared to me to be a fairly pain controlled, timely recovery and successful return to their regular daily activities.  I was told I was on the younger side for this type of procedure, nevertheless, would greatly benefit from extended quality of life and return to desired activity, given my current quality of life and daily activity was becoming more diminished by the day. My Knee Replacement I underwent RTKR on September 25.  All went well and as expected with the surgery.  I was up and walking, began some light physical therapy exercises, and maintained post-op range and motion through use of a CPM while in hospital.  I was discharged to home on the third day post-op, with a couple of narcotic pain medications (initially Percocet/Oxycodone and Morphine) and directions to commence in-home physical therapy the following day.  My follow-up visit with the surgeon was scheduled for 6 weeks post-op.  Day one at home began my challenging journey of recovery, both physically and emotionally.  I experienced difficulty managing my pain even with narcotics and over the counter medications.  My swelling was as expected and able to be kept in check with anti-inflammatory meds and icing.  I experienced annoying side effects from the narcotics, i.e., headaches, nausea, constipation, and thus was bounced from one medication and dosage to another, none of which seemed to be the right combination or solution to my pain.  Out of complete desperation and in uncontrollable pain, I went to the emergency room after being home for four days post-op, hoping to get some relief. A Problem with the Surgery? I thought surely there must be something wrong.  A few hours later, together with a lecture from the hospital PT and some morphine, I was discharged back to home.  Back on more medication, I failed to again find relief from pain.  I was averaging about 2-3 hours of sleep per night and little sleep during the day.  My home physical therapist had her work cut out for her.  Over the next 4 weeks (twelve 45 min. sessions of in-home PT), I had yet to reach better than 85 degrees flexion and 10 degrees extension.  My in-home therapist said she spent most of those 4 weeks strengthening my calves, hamstrings, and quad muscles, all which were extremely weak.  Therefore, already I was approximately 4 weeks behind in range and motion advancement.  My pain was still very much out of control, all while I feared becoming more and more dependent on the narcotics prescribed. At the first follow-up appointment (six weeks post-op), my flexion was below 90 degrees and extension still not at the zero degree mark.  I was informed by my surgeon that I needed a Manipulation Under Anesthesia (MUA).  My knee felt very stiff, pain was still unmanageable, and I was stuck without advancement in physical therapy. Manipulation Under Anesthesia He took x-rays and made sure the appliance was not loose or slipping out of placement.  All was found to be in proper order and an examination found no infection that could be causing pain or other symptoms.  My surgeon had done his job.  I was told however, that he believed I was stuck due to scar tissue build-up and thus was in need of the MUA to break up the scar tissue.  This would also permit the ability to continue physical therapy, working towards achievement of the desirable degree of range and motion outcomes.  I underwent the MUA six weeks and one day post-op and immediately resumed PT the following day.  I was told not to worry about a reduction in my flexion and extension after having the MUA.  An MUA tends to put patients back about 3-4 weeks, so it is almost like starting all over again.  However, the idea is that advancement in range and motion should become easier now that the scar tissue has been broken up by the procedure.  I went to PT for 5 days in a row the first week following the MUA, did my home exercises faithfully on my own twice a day, then returned to PT three times a week for the next several weeks. After the MUA At the two week follow-up appointment post the MUA, I was still in unmanageable pain, still getting only 2-3 hours of uninterrupted sleep per night, and running every gamut of emotion and temperament.  My poor husband was beside himself and wondering whatever became of the woman he married 27 years ago.  My flexion was still only reaching in the low 90's and my extension was no better either.  I was still experiencing great sensitivity to the touch anywhere on or around my surgical knee.  I couldn't stand wearing pants or having any sheet or blanket covering my knee.  My pain was the worst at night, just when I was settling in for some restful moments on the couch watching TV with my husband.  I would suddenly be lifted off my seat with either pain that mimicked touching a lit match to my knee, or the stabbing of a knife, or the shock of a taser. Dealing with the Pain This pain varied and sometimes was relentless for several minutes.  I was in tears most evenings and headed to bed to ice or apply heat, which calmed the nerve pain somewhat.  I would take meds (Hydrocodone/Norco, Extra-Strength Tylenol, Ibuprofen,  Zofran (for nausea) Vitamins, a stool softener (due to Hydrocodone) and Gabapentin aka Neurontin.  I was soooo sick of taking medications.  I think my surgeon was beside himself as to how to control my pain and sensitivity, therefore, he recommended I seek help at a Pain Management Clinic for possible sympathetic blocks, as well as my medicinal pain management.  Both he and my physical therapist told me I was forecasting pain neurologically before any exerted physical effort on their part was made to cause any pain.  My intolerance for any amount of pain was prohibiting any measurable progress in my range and motion, thus scar tissue was building at a rapid pace.  Physical therapy continued to be a challenge as I protective muscle guarded any force applied by my therapist to get better R&M.  I cried through most of my sessions. Pain Management At my first appointment with the Pain Management Clinic, I met with the doctor.  Most people have sympathetic blocks in their back to relieve nerve pain, but the doctor I was referred to chose to recommend a Genicular Neurotomy, accomplished through a procedure called Coolief Cooled Radiofrequency Ablation.  I first underwent a test which involved Lidocaine injections in four areas surrounding my new knee.  The patient then logs their pain and activities over the following 72 hours.  A follow-up appointment with a Nurse Practitioner then reviews the log and determines eligibility for the ablation procedure.  At this appointment she chose to cut my medication cold-turkey for a couple of days as she deemed I was dependent on them, even though I was getting little pain control.  I experienced severe withdrawal symptoms for two days. A Change in Medication I thought I was going to go out of my mind.  A change in my medication increased the Gabapentin I was taking, and I was found to be eligible for the ablation.  I underwent that procedure approximately 6 weeks post my first MUA, just before the Thanksgiving holiday.  I was told that I would still be experiencing pain for approximately 4-6 weeks, due to the fact that the ablation was going to make my nerves “angry” as they fought their temporary death.  I was also informed that this procedure is temporary as nerve endings most often regenerate themselves over a 6 month to 2 year period.  Some patients must undergo two or three of these procedures to get lasting relief. Unhappy News This was not happy news to my ears, yet I was still desperate for relief and reaching out for anything, and I mean anything, that would control my pain.  I returned to the pain clinic for a follow-up to the ablation procedure only to report pain still very bad and that I was still taking a boatload of medication, icing, heat to quad muscles to relieve cramping, and poor results in physical therapy sessions.  I was told to give it more time and come back in a few more weeks.   At my next follow-up approximately 3 weeks later, I discharged myself from the Pain Management Clinic.  I felt that their treatment plan was not successful for me and they had no other plan to offer other than continued reliance on prescription medication and time. When recovery goes wrong – Read More A Desparate Time After barely getting through the Christmas holidays, persisting in physical therapy and weaning myself down on prescription medications (since they didn't seem to be having any great effect on my pain), I began to explore the possibility of medical marijuana as a solution to my pain control.  I have never tried marijuana and had little desire to smoke or vape it, but was interested in edibles they have out now.  I was desperate and finding myself sinking into anxiety, panic attacks and, at times, depression.  My family and my husband were becoming very concerned as I was changing into a person they did not know and they were at a loss as how to help me through my circumstances. Medical Marijuana Since medical marijuana is legal in the State of Arizona, I sought out a doctor with whom I met and applied for a patient card.  This process took approximately 3 weeks, including approval of my application through the Arizona Department of Health and Human Services.  Upon receiving my card, I met with a licensed nurse at a dispensary to become educated about the various products and my specific needs.  She was recommended by the doctor who signed off on my patient eligibility and works with a number of cancer patients to help control their symptoms.  We met for over an hour.  She was extremely patient with me, educating me about cannabis (which I knew little of) and gave me recommendations to try.  I purchased three of her recommendations.  I also decided to try getting a light massage once per week.  The massages lasted for approximately three weeks before I decided to suspend them, as I found them not helpful enough to warrant the expense. Little if Any Improvement Having done everything I was asked to do in my recovery and still making little if any gains, I found myself in a very dark place emotionally, desperate to end my pain, and I was done!!  One day, I was occupying my time, in between home therapy and out-patient therapy sessions, searching the Internet for anything that might literally save me.  When in answer to my prayer, I came across several website postings about a therapy called X10.  I shared some of it with my husband, my parents and my kids.  They encouraged me to explore it more.  After reading some of the patient blogs and watching a few of the videos that I could access, I made my first contact with PJ Ewing by emailing him.  PJ responded very quickly telling me that the X10 Therapy and machine was not yet available in the State of Arizona, but he provided me with some other resources.  I was initially devastated by this news, but I almost immediately decided that I was not going to accept that response.  I instantly thought to myself, “Well, if it is not available in AZ, then maybe I can travel to wherever it is available. Not Taking ‘No’ for an Answer This time, I placed a phone call to PJ and we talked for over an hour.  As it so happened, in our conversation I discovered that the X10 headquarters is in Franklin, MI, and I had family who lived in Rochester, MI.  PJ was more than gracious in discussing all the parameters and specifics of the possibility of travel to Michigan to undergo the X10 program.  To say the least, after completion of my discussion with PJ, I heard God say “Not yet, Cathy, I still have a plan for you on this earth.”  I discussed the possibilities with my husband and shared them also with my son and daughter-in-law, exploring their permission to have me as a houseguest for 2-3 weeks.  Of course, they couldn't have been more gracious and welcoming. Pain Still a Big Problem My pain was still out of control, I continued out patient PT three times a week with slow or little advancement in my R&M, had my six week MUA follow-up with my surgeon only to be told I was facing a second MUA.  I told my surgeon and my physical therapist about the X10 Therapy website I had discovered, and PJ sent me the clinical data to share with them.  Each of them, I am grateful to say, told me they had looked at the data and were “intrigued” by the therapy plan.  Both encouraged me to pursue it as an option for me, yet both also strongly indicated that enough time had passed between my first MUA and the ablation, therefore, still recommended I have the second MUA before commencing X10 Therapy. Turning to X10 Therapy after a Second MUA Once my husband and I had made the decision to pursue this plan, the wheels began to roll quickly.  Initially, I scheduled the 2nd MUA and a flight out from Phoenix to Detroit by myself the next day following the MUA.  I notified PJ of my  plans and he began to put things in motion by placing me in contact with Mary Elliott, Melissa, Mike, a therapy Coach, Erin a Physical Therapist, and Marty, a technician for machine home delivery and set-up.  The X10 Therapy approach is really a “team” approach to wellness, in addition to the machine itself and the technological programs it delivers to the patient. The Second MUA Was Coming Up As the days approached the 2nd MUA, I became extremely anxious and experienced a couple of panic attacks.  I began to stress about the MUA pain, having gone through one already.  The thought of flying alone, even though my son would be there to meet me at the other end of my flight, and having to get through a 4 hour flight plus 1 hour car ride to his home in pain, had me scared beyond belief.  I was consumed with thinking about how I would manage my pain.  Should I just knock myself out to sleep on the plane?  What if that didn't work?  What meds could I then take if in pain?  What about my leg position – straightening and bending?  How would I get help from curb, through security, to gate, onto plane and the same again when arriving including a stop at baggage claim?  How am I going to sleep at night?  Is this therapy going to put me back in unmanageable pain again, even though the X10 Therapy information says I am in control?  What if it doesn't work?  Can this end my knee recovery nightmare? And on and on and on…! Making Plans After talking it over with my husband and doctor, it was decided that I would delay my trip to Michigan for one week following the 2nd MUA.  I would continue outpatient PT immediately following the MUA, but have some time to consult with a psychologist concerning my sleep depravation, fears, anxiety/depression and develop a plan to manage my pain, as well as talk to the airline for special assistance to help solve my transportation needs.  My husband decided to make the trip with me for a couple of days, just to get me settled and started with X10 Therapy.  Armed with a revised medication and travel plan, I notified the X10 Team of my change in start date and all were extremely understanding and accommodating.  I had the 2nd MUA  on January 18.  I continued outpatient PT for three more sessions, in addition to my own home exercises twice per day.  My daily sleep and pain control was managed better and I was counting the days until our departure date.  It simply could not arrive fast enough! Friday, January 19 This will remain a very important and pivotable day in my life.  My journey towards healing, life anew and well-being would begin that very day.  Having endured a comfortable flight and having managed all the transportation arrangements with ease (kudos to Delta Airlines), we arrived at my son's home ready to commence what I can now claim as my own personal miracle.  Within an hour, Marty arrived with a smile, this technological marvel known as the X10 machine, and a thorough first orientation/training session filled with words of encouragement and confidence.  I was on my way, although until I began to see results (which were really displayed within that first session), I Had Hope I was still cautiously optimistic about where I was headed.  Could I really achieve the flexion and extension goals I was unable to achieve thus far with any of my existing recovery methods?  Would this therapy really enable me to manage my pain comfortably with mild medications?  Could I trust my X10 therapist and her plan for me?  Would the X10 team really be there for me when I needed them?  Was the X10 therapy the answer to my prayers?  Would I really be returning home in as little as  just over 2 weeks time to see my surgeon's and physical therapist's jaws drop as they witnessed my flexion and extension reach what we all thought would be skeptical results, but instead blow them away with incredible success?  It would not be long before I could actually acknowledge to myself that the answers to each of those questions would be a resounding YES! 110º Flexion Once I was able to reach the 110 degree mark for flexion, it was decided that I would add 5 min a day on the stationery bike. As I felt comfortable, I was able to increase that time in small increments and add another bike session in the evening.  While my progress was measurable daily, I did experience some cramping in my right thigh and calf, dealt with some bursitis in my right hip for about two weeks, and waking with some right leg pain some nights. Taking Care of Myself I found icing and elevating regularly after each exercise session, icing my hip, heat on my upper thigh at night, Tramadol 50 mg. only twice a day with Ibuprofen and Acetaminophen alternated during the day, and Theraworx Relief foam massaged in the cramping areas once or twice a day helped keep my discomfort manageable.  In addition, I spent some resting time researching dietary recommendations for inflammation and pain.  I incorporated tumeric, magnesium, Osteo Bi-flex, 100% Cherry or Pineapple Juice, Vitamin B6 & B12, Vitamin C, Vitamin D3, Zinc, fresh berries and decaffeinated tea with ginger, lemon and honey in my daily diet.  I also decided to limit carbohydrates and sugar intake in an effort to keep my inflammatory response in check. One Week In After one week on the X10 and with constant reassurance and communication from all of my X10 team, I could actually begin to call this journey and the X10 Therapy my miracle.  I had breached the 100's for flexion after starting at 55 degrees, and reached 0 degrees at the end of the first session on my extension, previously at 8 degrees.  My fears, anxiety and uncertainty soon gave way to renewed love for life, joy at gaining confidence in doing daily activities again, sharing my daily success by telephone with family and friends, and hope for the future.  The almost daily contact from one or more of my X10 team members answered any questions that arose, provided authentic cheerleading for my cause, and motivated me to press on for better and better results. Working with My Coach Mary called often to check in with me and was my calm and steady encourager.  My conversations with her were uplifting and kind of like talking to an old friend, casual and comforting.  My PT, Erin, made a home visit to discuss my history and offered varied strategies for increasing my flexion degrees, as well as made adjustments in my therapy plan due to some bursitis that I had recently developed in my right hip.  She was careful to make the appropriate adjustments to my therapy plan.  She and Mike (my strengthening coach and with whom I also met in person to go over exercises), together modified my plan by delaying some of the exercises, while still permitting three sessions a day for range and motion growth. Conclusions As I approach my last day of sessions on the X10 Therapy machine and a return home to Arizona tomorrow, I write my story to encourage anyone who has experienced one or more of the circumstances that I experienced subsequent to a total knee replacement.  I am happy to report that I was successful in breaking through some of my scar tissue, reaching 0 degrees for my extension and 117 degrees flexion.  My gait is much improved and, as I have returned to walking without a limp or dragging my surgical leg, the pain in my hip and lower back has also improved greatly. My knee recovery nightmare has finally come to an end. Some Rehab Insurance I will continue outpatient therapy immediately upon my return home in order to solidify my current range and motion, and even further improve my flexion as I am able.  I write this also as a means of paying it forward to future patients of the X10 and in grateful appreciation to my X10 Team, my family and my friends who affirmed, guided, encouraged, and yes, celebrated, my X10 Therapy journey of success.  The proof, as they say, is in the pudding, which is said to mean that you can only judge the quality of something after you have tried, used, or experienced it.  I absolutely cannot wait to share my experience and demonstrate my range and motion achievement in person to my surgeon and PT Team back home in Arizona. Thanks be to my God, to all of my support team and to X10 Therapy… life is good once again! To read about total knee replacement for a younger population, click here. The X10 Meta-Blog We call it a “Meta-Blog” because we step back and give you a broad perspective on all aspects of knee health, surgery and recovery. In this one-of-a-kind blog we gather together great thinkers, doers, writers related to Knee Surgery, Recovery, Preparation, Care, Success and Failure. Meet physical therapists, coaches, surgeons, patients, and as many smart people as we can gather to create useful articles for you. Whether you have a surgery upcoming, in the rear-view mirror, or just want to take care of your knees to avoid surgery, you should find some value here. #mc_embed_signup{background:#fff; clear:left; font:14px Helvetica,Arial,sans-serif; }/* Add your own MailChimp form style overrides in your site stylesheet or in this style block.We recommend moving this block and the preceding CSS link to the HEAD of your HTML file. */ Subscribe to the Blog Here * indicates required Email Address * First Name Last Name

National carrot cake day. Entertainment from 1986. Plan crash killed Buddy Holly-Big Bopper-Richie Valens, Coldest temperature ever recorded in North America, 15th & 16th Amendments to the US Constitution ratified. Todays birthdays - Blythe Danner, Dennis Edward, Morgan Fairchild, Nathan Lane, Maura Tierney, Warwick Davis, Isla Fisher.Intro - Goe did good - Dianna Corcoran  Dianna on SpotifyOh, carrot cake, so delicous - The Hungry Food bandThat's what friends are for - Dionne Warwick and friendsHurt - Juice Newton American pie - Don McLeanBirthdays - In da club - 50 Cent     http://50cent.com/Just my Imagination - The TemptationsBetrayed - Nathan LanePeggy Sue - Buddy HollyExit - Back of a pick-up truck - Brad Howard  Brad on Spotifycountryundergroundradio.comHistory & Factoids about today webpagecooolmedia.com

Why This Natural Compound Can Reduce Pain Like Ibuprofen (Without the Gut Damage) | Podcast #470

Just a half teaspoon of this natural anti-inflammatory acts as a potent ibuprofen substitute for inflammation and pain relief. Discover the best home remedies for pain and inflammation, and learn how to address inflammation at the root. 0:00 Introduction: Natural ibuprofen substitute 0:18 Curcumin, the natural anti-inflammatory 1:58 Pain relievers and ibuprofen comparison 2:08 Ibuprofen effects 3:25 Turmeric as a natural remedy vs. ibuprofen 4:32 More natural pain relief alternatives 6:15 Triggers of pain and inflammation8:25 Preventing inflammation Turmeric contains a potent compound called curcumin that can naturally alleviate pain and inflammation.There are 4 biochemical pathways that act as “master switches” to turn pain and inflammation up or down:1. Pain and inflammatory factory2. Master inflammation on-switch3. Inflammation megaphone 4. Backup inflammatory alarm system Many inflammatory treatments do not address all four pathways. Ibuprofen is great at turning the pain and inflammation switch off, and does so very quickly. Unfortunately, this pathway protects the stomach and kidneys, so ibuprofen can cause stomach ulcers and kidney issues. It also doesn't address the other inflammatory pathways, which is why people often have to take it repeatedly. Tylenol works in the brain, affecting the central nervous system, but does not relieve any inflammation. Similar to ibuprofen, aspirin works on the first inflammatory pathway, which can also affect your stomach.Turmeric affects 3 out of the 4 inflammatory pathways! A double-blind randomized controlled study found that taking 1500 mg of turmeric with black pepper produced results comparable to ibuprofen without the side effects. Extra-virgin olive oil mimics ibuprofen's effects at the molecular level. Try adding it to your salad regularly! Ginger and omega-3 fatty acids also work to reduce inflammation. Boswellia targets the 5-LOX pathway, also known as the backup inflammatory alarm system.There are 5 primary causes that flip the inflammatory switches on, leading to pain and inflammation in the body. By addressing the root cause, you can correct the pain rather than simply managing it. The following 5 factors turn on all of the inflammatory switches:1. Insulin resistance2. Mitochondrial damage3. Chronic oxidative stress4. Leaky gut5. Chronic infectionsTo prevent inflammation and address the root cause, try the following:• Low-carb diet • Eliminate ultra-processed foods• Intermittent fasting/prolonged fasting• Magnesium, vitamin D3, zinc, omega-3sDr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.

Episode Description:

Send us a textEpisódio 69 — Controvérsias sobre persistência do canal arterial em prematuros: o que a evidência realmente mostraA persistência do canal arterial em prematuros segue sendo um dos temas mais debatidos da neonatologia moderna — e talvez um dos mais desafiadores. Durante anos, aprendemos que identificar e fechar o canal era sinônimo de fazer o “certo”. Mas, à medida que grandes ensaios clínicos foram publicados, essa certeza começou a ruir.Neste episódio especial, mergulhamos nas principais evidências que mudaram — e continuam mudando — a forma como pensamos o canal arterial: por que ele se mantém aberto, o que realmente acontece do ponto de vista hemodinâmico, quando (e se) devemos intervir, e quais desfechos importam de verdade.Revisitamos estudos marcantes, discutimos suas perguntas, métodos, resultados e implicações práticas, trazendo o olhar crítico para o contexto das UTIs neonatais brasileiras — onde os recursos, as rotinas e os desafios nem sempre são os mesmos dos grandes centros de pesquisa.Mais do que procurar respostas definitivas, o episódio convida à reflexão: o canal arterial é vilão, espectador ou marcador da imaturidade extrema? Estamos ajudando nossos pacientes quando intervimos precocemente — ou apenas fechando um número no ecocardiograma?1. Baby OSCAR: Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen  https://www.nejm.org/doi/full/10.1056/NEJMoa23055822. Two-year outcomes after selective early treatment of patent ductus arteriosus with ibuprofen in preterm babies: follow-up of Baby-OSCAR–a randomised controlled trial - https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(25)00356-6/fulltext3. BeNeDUCTUS: Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus https://www.nejm.org/doi/full/10.1056/NEJMoa22074184. Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants - The PDA Randomized Clinical Trial https://jamanetwork.com/journals/jama/article-abstract/2842696?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jama.2025.233305. TIPP Trial: Long-Term Effects of Indomethacin Prophylaxis in Extremely-Low-Birth-Weight Infants https://www.nejm.org/doi/full/10.1056/NEJM2001062834426026. Current approaches to the patent ductus arteriosus: Implications for pulmonary morbidities https://pubmed.ncbi.nlm.nih.gov/40450478/ Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Nutritionist Leyla Muedin details key aspects of supplement use and addresses frequently asked questions. Topics include the importance of targeted supplementation, the rationale behind personalized dosages, best practices for starting new supplements, and managing common issues like nausea and bright yellow urine. Leyla also explains why some supplements may cause gastrointestinal discomfort and provides guidance on how to adjust dosages for optimal results. Emphasis is placed on the benefits of pharmaceutical-grade supplements available on Fullscript and the necessity of regular blood tests to fine-tune supplementation.

In this episode, Therese Markow and Dr. Tami Rowen discuss the controversy surrounding the use of Tylenol during pregnancy and its potential link to autism. She emphasizes that the evidence is largely anecdotal and not supported by robust scientific studies. Dr. Rowen highlights a study published in Environmental Health in 2025 that found a weak association between Tylenol use and autism, but adds that a subsequent study revealed flaws in the earlier study and showed no association.  Fever in pregnant women can have dangerous effects and should be relieved. She stresses that Tylenol is the safest pain reliever and fever reducer for pregnant women, who experience fevers in 20% of pregnancies. Dr. Rowen criticizes the media and some health officials for misrepresenting the risks, potentially leading to harmful decisions by pregnant women.    Key Takeaways: Tylenol is the safest option that we have in terms of a fever reducer and pain reliever. Fevers actually have more association with autism than Tylenol does in the research. On the other hand, Ibuprofen and NSAIDs are unsafe in pregnancy, especially in the third trimester.    "Pregnancy is quite an uncomfortable state of being. We tell pregnant women, and we tell women in general, to tough out a lot of things, but pain is not something that I think is reasonable. I think that it goes against the principle of doing no harm, to tell people they should just suffer with pain when there is actually effective and safe medication for them." —  Dr. Tami Rowen   Episode References:  The Conversation Article: https://theconversation.com/as-an-ob-gyn-i-see-firsthand-how-misleading-statements-on-acetaminophen-leave-expectant-parents-confused-fearful-and-lacking-in-options-265947    Connect with Dr. Tami Rowen: Professional Bio: https://profiles.ucsf.edu/tami.rowen    Connect with Therese: Website: www.criticallyspeaking.net Bluesky:@CriticallySpeaking.bsky.social Email: theresemarkow@criticallyspeaking.net   Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it.  

From a U. S. Army Combat Veteran Mindset to Tractor Supply Leadership: Building Teams, Safety, and Continuous Improvement This week, Marcus and Melanie welcome Rodney Bailey, a devoted husband, father, and decorated U.S. Army combat veteran whose leadership has been shaped by four combat tours and distinguished honors, including the Purple Heart and Meritorious Service Medal. He now applies that mission-driven discipline at Tractor Supply Company, where he leads operations and continuous improvement initiatives that strengthen safety, streamline performance, and unlock millions in new production capacity. A Lean Six Sigma Black Belt and Human Performance Advocate, Rodney is committed to developing leaders and building teams who pursue excellence with pride and purpose. A lifelong learner who embraces challenge, he is currently earning his Doctorate in Business with a focus on Strategy and Innovation. Through it all, he remains anchored in faith, family, and service—values that also inspired his children's book, God Is Bigger Than a Bear. A National Impact Rooted in Community Marcus and Melanie also welcome Lindsay Grayson, who serves as the Chief Revenue Officer at K9s For Warriors, overseeing the Development and Marketing teams as she drives brand visibility, deepens donor engagement, and accelerates revenue growth for the nation's largest provider of trained service dogs for military veterans. Since joining the organization, Lindsay has reshaped its fundraising trajectory—boosting revenue by 70% in her first year and leading K9s For Warriors to a historic, record-setting year of giving in 2023. Her performance and impact earned her recognition as a Jacksonville Business Journal Women of Influence honoree. Prior to her nonprofit leadership career, Lindsay worked as a financial advisor with Merrill Lynch, guiding clients through strategic planning and long-term financial goals. A Jacksonville native and proud spouse of an Air Force veteran and First Responder, she finds joy in family time, travel, live music, and cheering on her children, Lucas and Ebby. In This Episode You Will Hear: • At redeployment, something happened to me. During Ramadi, they started really looking at traumatic brain injuries. They started putting sensors in the helmets. (30:34) • If you didn't lose a liter of blood or you're not missing a body part, it's Ibuprofen & water. (30:54) • When I got back and they hooked up my helmet, and they're like: “something's up.” (31:02) • At 31:10, Rodney tells of one of his traumatic brain injury events as a 50 cal gunner. [He hit the gun at 20mph. It was the only thing that kept him from being thrown from the vehicle. • I did about 5 months in another deployment and was Medivacked out to Germany with another head injury. (32:29) • It wasn't like I had to learn to walk again. I had to learn how to walk straight. (33:35) • You know that you have to wait for that 30, 45 to 90 second, depending on what kind of round it is. And then you hear the sound – “Here it is.” You gotta run, just hoping that it doesn't hit you. (36:05) • There's beauty in some fights. (38:33) • Sometimes there's like a calm and pause in war. (42:35) • If you're gonna transition from the military, I think there's some things that are grounded in you – core beliefs, values, and everything like that. (49:26) • At Tractor Supply, one of the things that brought me to it is the core missions and values. (49:46) • 10% of all people who work for Tractor Supply are veterans. (50:46) • This was the first company that actually told me, “Hey, go home and spend time with your family.” (51:13) • [Lindsay] Tractor [Supply} has helped put mor leashes in the hands of veterans, and they really believe in our mission. (54:51) • Lindsay shares how veterans go about applying for a canine from CaninesforWarriors.org. (55:31) • [Marcus] We're conditioned to come in – we're not conditioned to get out. (57:31) • The only thing that's gonna stop you, is you. (70:32) • Sometimes you're dealt with cards, but you're writing the book of your life. (72:21) Support Tractor Supply:   -  Tractorsupply.com/hometownheroes Support K9s For Warriors:   - K9s For Warriors - Service Dogs for Veterans with PTSD   Support TNQ   - IG: team_neverquit , marcusluttrell , melanieluttrell , huntero13   -  https://www.patreon.com/teamneverquit Sponsors:   - Tractorsupply.com/hometownheroes   - Navyfederal.org        - Dripdrop.com/TNQ   - ShopMando.com [Promo code: TNQ]   - mizzenandmain.com   [Promo code: TNQ20]   - meetfabiric.com/TNQ   - masterclass.com/TNQ   - Prizepicks (TNQ)   -  cargurus.com/TNQ    - armslist.com/TNQ    -  PXGapparel.com/TNQ   - bruntworkwear.com/TNQ    - Groundnews.com/TNQ    - shipsticks.com/TNQ    - stopboxusa.com {TNQ}    - ghostbed.com/TNQ [TNQ]   -  kalshi.com/TNQ   -  joinbilt.com/TNQ    - Tonal.com [TNQ]   - greenlight.com/TNQ   - PDSDebt.com/TNQ   - drinkAG1.com/TNQ   - Hims.com/TNQ   - Shopify.com/TNQ

Send us a textThis discussion features Dr. Clyde Wright, Professor of Pediatrics at Children's Hospital Colorado and the University of Colorado School of Medicine, who studies perinatal innate immunity and neonatal lung injury. He highlights the rapid rise of acetaminophen as the most commonly used medication for ductal closure in preterm infants despite limited long-term safety data. Dr. Wright explains how acetaminophen metabolism via CYP2E1 produces a reactive metabolite that may affect mitochondrial function in developing lung cells, prompting consideration beyond hepatic toxicity markers. He encourages clinicians to remain judicious, especially outside optimal treatment windows, and calls for research incorporating respiratory outcomes and nuanced, individualized risk–benefit discussions at the bedside.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Kann man Sudan und Gaza vergleichen? Krise der Halbleider. Trumps Einpeitscher Bannon fürchtet Knast. Darf man "Nichtsdestotrotz" noch sagen? Restkarten zur Jubiläumsshow: Die Mutmacher am 26.11. live in Berlin zur 1000. Folge. Bestens gelaunt präsentieren Paul und Hajo Schumacher aus dem Schöneberger Hinterhofstudio die frische Wochenschau. Unsere Themen: Aero-Mobbing gegen Außenminister Wadephul? Die arschatmende Furzgundel zurück im Main. Wer war Wolfdietrich Schnurre? Football-Klimbim am deutschen Schicksalstag. In Tokio nur Bahnhof. Berliner SPD zelebriert Selbstzerstörung. Malediven rauchfrei. Was Hunde wirklich kosten. Vatis Cordhose und Spießerkrieg gegen Motten. Drei Tabakpflanzen pro Person. Jetzt wird auch noch das "V" gecancelt. Berghain, Rosalia und Mutters Trendorakel. Boomer-Babos scharf auf Haftbefehl. Moskop, Jawatnu und Derzeit erhöhte Nachfrage. Plus: Beton und Ibuprofen. Folge 995.Folgt dem MuMaPoCa auf InstagramAchtung, hier gibt's ab sofort Tickets. Zur 1000. Folge geht der MutMachPodCast live, am 26.11. 2025 im Café Zart a.k.a. House of Podcasts in Berlin-Kreuzberg.Tickets für Pauls Band Udo Butter und das Team am 13.11. im LidoSWR-Petition Eisenbahn-RomantikUnsere Live-Folge von der PLAY-Konferenz über ErfolgPaul und Hajo über SelbstständigkeitPodcast Elefantenrunde mit Frank Stauss und HajoPauls Band: Udo Butter und das TeamBücher:Suse SchumacherDie Psychologie des Waldes, Kailash Verlag, 2024 Hosted on Acast. See acast.com/privacy for more information.

Most people assume that if a drug sits on the shelf at Costco or Walgreens, it must be pretty safe. But what if some of the most common over-the-counter (OTC) medications are among the riskiest drugs in America? On this episode of Vitality Radio, Jared exposes the hidden dangers behind everyday pain relievers, sleep aids, and heartburn drugs—medicines that cause thousands of deaths every year when misused or taken long-term. You'll learn how a drug becomes “OTC,” what happens when pharmaceutical companies push for that switch, and why the FDA's approval process might not tell the whole story. Jared dives into the startling realities of PPIs like Prilosec, NSAIDs like ibuprofen, and acetaminophen (Tylenol)—uncovering their risks to the liver, kidneys, bones, and brain. He also discusses how marketing convinces consumers these drugs are harmless. Finally, Jared offers a resource for safe, natural alternatives for reflux, pain, inflammation, sleep, and immune support—options that nourish the body instead of depleting it. This episode will change the way you look at “harmless” OTC drugs and help you take real control of your health.Just Ingredients Lemon Swish Protein Powder Vitality Radio POW! Product of the Week $29.99 per bag (regular price $59.99) with PROMO CODE: POW15Additional Information:#341: Your Digestive Health Supplement User's Guide. From IBS to Acid Reflux - Learn How to Balance Your Gut Health With Natural Products. #522: Q&A Show #5 - Jared Answers Your Questions About Energy and Sleep!#471: Boosting Your Immune System Ahead of Winter #553: Boswellia & Curcumin: Nature's Dream Team for Pain & Inflammation with Dr. Lexi LochVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Send us a textBem-vindos a mais um episódio de A Incubadora, nosso podcast quinzenal que tem como missão democratizar o conhecimento em neonatologia e ampliar o acesso às melhores evidências científicas — de forma acessível, crítica e baseada em dados.No episódio de hoje, vamos mergulhar em quatro estudos de grande impacto publicados recentemente e destacados pelo EBNeo entre os artigos de neonatologia do ano. Eles abordam temas centrais da prática clínica neonatal, com potenciais implicações diretas na tomada de decisão à beira do leito:Effect of Early vs Late Inguinal Hernia Repair on Serious Adverse Event Rates in Preterm Infants — um ensaio clínico randomizado que discute o melhor momento para a correção de hérnia inguinal em prematuros. https://jamanetwork.com/journals/jama/fullarticle/2816629?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jama.2024.2302Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen — que traz novos dados sobre o manejo precoce e seletivo do canal arterial. https://www.nejm.org/doi/pdf/10.1056/NEJMoa2305582STAT trial: stoma or intestinal anastomosis for necrotizing enterocolitis — um estudo multicêntrico que compara duas estratégias cirúrgicas no tratamento da enterocolite necrosante. https://link.springer.com/article/10.1007/s00383-024-05853-3Nirsevimab for Prevention of Hospitalizations Due to RSV in Infants — evidências robustas sobre a eficácia da imunização passiva na prevenção de hospitalizações por VSR. https://www.nejm.org/doi/pdf/10.1056/NEJMoa2309189Prepare-se para uma discussão aprofundada sobre metodologia, resultados e implicações práticas desses estudos que estão ajudando a moldar o futuro do cuidado neonatal. Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Nico hat mich trotz Erkältung ans Mikrofon gezwungen! Er schrieb mir gestern Abend eine Nachricht, die ich gerne mit euch teilen möchte:"Hallo,Es ist nicht in Ordnung, als Podcast-Azubi krank zu machen während ich dich brauche. Eine Erkältung und Fieber kriegt man auch mit Tee und Ibuprofen weg. Das schadet mir und deiner Ausbildung. Wenn das weiterhin vorkommt, muss ich ernsthaft über eine Kündigung nachdenken. Bitte nimm deine Verantwortung ernst.Viele Grüße,Ocin Remyeh"So bleibt mir nichts zu sagen außer viel Spaß mit der neuen Folge!+++ Alle Rabattcodes und Infos zu unseren Werbepartnern findest du hier: LINK +++

The “China Study” is cited as evidence vegetarian diet is best—but big new study shows vegetarians age less well than omnivores; Can a popular men's health supplement ward off prostate cancer? MAHA officials hit pause on looming natural thyroid ban; Can diet alleviate symptoms of lipedema? Precision-engineering your gait can alleviate knee pain better than NSAIDs; After a lifetime of profound depression, novel brain implant enables man to experience joy for the first time.

On this episode of Vitality Radio, Jared explores why gallbladder removal has become one of the most common surgeries in America—and why it may not be the best solution. Too often, modern medicine treats the gallbladder as disposable, removing it without addressing the real root causes of bile problems, gallstones, or digestive distress. Jared breaks down what the gallbladder does, why it matters for digestion, nutrient absorption, and detoxification, and how stress, diet, and liver health all play a role in gallbladder function. You'll learn practical strategies to protect and support your gallbladder naturally, as well as tools for those already living without one. From lifestyle changes and mindful eating to supplements like digestive enzymes, ox bile, apple cider vinegar, bitters, and liver support nutrients, Jared highlights effective ways to restore balance to digestion and keep your bile flowing smoothly. Whether you still have your gallbladder or not, this episode will give you the insight and confidence to take better care of your digestive health.Products:Back on TractApple Cider VinegarWishgarden Badass BittersLiverVitalityOx BileTUDCAAdditional Information:#507: Comprehensive Digestive Support to Get Your Gut ‘Back On Tract'!#552: Grandma Was Right! The Many Benefits of Apple Cider Vinegar#266: Prescribing Poisons Part 2. Ibuprofen, PPI's, and Fluoroquinolone AntibioticsVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Contributor: Aaron Lessen, MD Educational Pearls: Recorded March 2025 What is the best treatment for a fever? Tylenol? Ibuprofen? Combined? Alternating the two? The journal Pediatrics aimed to answer this question with a meta-analysis of 31 randomized controlled trials including 5,009 febrile children. Results showed that both combined and alternating acetaminophen/ibuprofen regimens were significantly more effective at reducing fever at 4 and 6 hours compared with acetaminophen alone, with numbers needed to treat (NNT) of 3 and 4, respectively. High-dose ibuprofen alone also offered modest benefit (NNT 8). What dose should I use? Oral acetaminophen 10 to 15 mg/kg Every 4–6 hours as needed Do not exceed 75 mg/kg/day (or 4,000 mg/day maximum for older/larger kids) Oral ibuprofen 5 to 10 mg/kg Every 6–8 hours as needed Do not exceed 40 mg/kg/day (or 2,400 mg/day maximum for older/larger kids) References De la Cruz-Mena JE, Veroniki AA, Acosta-Reyes J, Estupiñán-Bohorquez A, Ibarra JA, Pana MC, Sierra JM, Florez ID. Short-term Dual Therapy or Mono Therapy With Acetaminophen and Ibuprofen for Fever: A Network Meta-Analysis. Pediatrics. 2024 Oct 1;154(4):e2023065390. doi: 10.1542/peds.2023-065390. PMID: 39318339. Summarized by Jeffrey Olson, MS4 | Edited by Jeffrey Olson and Jorge Chalit, OMS4 Get your tickets to Tox Talks Event, Sept 11, 2025: https://emergencymedicalminute.org/events-2/ Donate: https://emergencymedicalminute.org/donate/

Did you know the humble bottle of extra virgin olive oil in your pantry could be doing more than just making your salad taste good? In this episode, I’m unpacking a game-changing compound found in high quality EVOO – oleocanthal – which behaves just like ibuprofen. We’re talking natural anti-inflammatory power that can help reduce exercise-associated inflammation, support recovery and keep your immune system firing – without wrecking your gut or kidneys like NSAIDs can. You’ll learn: What oleocanthal is and why it’s like nature’s ibuprofen How to spot a good quality EVOO (not all are created equal) Why this simple pantry staple could be a secret weapon in your recovery strategy LINKS: Link to paper

In this episode of the Bacon, Bibles, and Barbells Podcast, some of the High Calling Fitness Coach Justin breaks down 10 supplements that people may think are HARMLESS, but can actually cause real damage to your overall health when used for too long or in the wrong context over time. Unfortunately, Coach Bill was not able to finish out the podcast due to storms in his area and internet issues towards the beginning of the show. The "supplement" industry is kind of like the wild, wild west right now in the health and fitness industry. There are a lot of these things that can be used properly in the right context with the right person, but we never recommend just starting a supplement that a friend recommends or that might fit your symptoms without careful analysis. Some of these things can REALLY harm your body when used in the wrong context or for too long of a period of time. Find out what ones we are most leery of when consulting with clients and which ones we have seen do the most damage by diving into this podcast! Let us know in the comments what your experiences have been or what else you think should be on the list! Give it a listen here or wherever you get your podcasts! Just look up Bacon, Bibles, and Barbells! Enjoy the episode! As always, if this is helpful and enjoyable to you, please LIKE, SHARE, and SUBSCRIBE to our channel! New informational videos are put out every week! Interested in working with one of our coaches here at High Calling Fitness? Head on over to www.highcallingfitness.com and schedule a free discovery call with us at the bottom of the page. We would love to chat with you more about your goals and how our health and fitness coaching could be a help to your and your family. Even if you don't hire us, we would love to chat and give you some free advice to take forward in our call . We our a group of reformed christian men and women who are committed to take the mandate of stewardship seriously in the care of the gift or our bodies. We hope to encourage others to do so as well by teaching and equipping them. Lord willing, we will all become more capable for as many years as God gives, building the kingdom of God together and enjoying the good gifts we are given in this life...all to the GLORY OF GOD!

Are over-the-counter painkillers silently wrecking your liver? Tylenol for a headache. Ibuprofen for sore muscles. PM meds to help you sleep. They're so common we don't think twice… but your liver does. Your liver is one of the hardest-working organs in your body, and when it's overworked or congested, everything suffers—your hormones, your energy, your digestion, even your sleep. The good news? It's also one of the most resilient organs you have. With the right care, you can restore its function and unlock better energy, clearer thinking, and hormonal harmony. In this episode of The Health Made Simple Show, Dr. Bart shares:

New study shows mood, attention, brain function improvements after 2-week smartphone “fast”; Natural ways to combat the pain of neuropathy; Solutions for painful swollen lower extremities; Omega-3 reduces depression in bipolar disease; Berberine for blood sugar control; Study demonstrates comprehensive lifestyle program reverses cognitive decline; NSAIDs for knee pain—more is not better; Nighttime pistachio snack curbs pre-diabetes.

Natural health guru and nutritionist Clive de Carle is back. As before, he presents some revelations which fly in the face of what we are told by conventional “doctors” and Big Pharma, notably involving Ibuprofen and Paracetomol. He also addresses the shutting down of the “spiritual” aspects of ourselves which many such products seem to bring about.Fortunately, says, Clive, natural and herbal solutions are available to mitigate all of the damage done through Organised Society.Any of the products mentioned by Clive can be ordered through the following affiliate link. This brings a small commission to Mark, supporting both him and Clive and helping their respective work to continue.https://clivedecarle.ositracker.com/361820/11489Become a supporter of this podcast: https://www.spreaker.com/podcast/good-vibrations-podcast--2594848/support.

Why do even highly educated women still feel completely unprepared when it comes to their reproductive health? In this episode, Michelle shares how personal data, cycle charting, and a deeper understanding of your body can change everything. Follow this link to view the full show notes page! This episode is sponsored by Lisa's new book, Real Food for Fertility, co-authored with Lily Nichols! Grab your copy here! 

For the past year, I've been looking for a doctor who can help me navigate the wild, uncharted terrain of perimenopause. A wild ride...and the parallels to my work in Feng Shui have been illuminating.   RESOURCES: join the conversation | *Become Your Own Feng Shui Consultant* course subscribe to the newsletter | Simple Shui buy the book | Simple Shui for Every Day: 365 Ways to Feng Shui Your Life follow along | Instagram

What's the problem with antibiotics anyway? On this episode of Vitality Radio, Jared passionately answers this question. There is no antibiotic that doesn't cause harm. That's not to say they don't have their place, but as Jared explains, they are almost never necessary and almost always prescribed for common problems like UTI's and sinus infections. You'll learn why many infections don't need, and won't respond to antibiotics, the ramifications of even a single dose of antibiotics, and how antibiotic superbugs are a real problem. Jared delves into why antibiotics are overused, side effects of particularly dangerous forms, and the effects on mental health and the immune system. This show will be followed with one on antibiotic alternatives and ways to rebuild your microbiome after antibiotic exposure.Additional Information:#264: Emotional Vitality: Jen's Story Part 1 - From Addiction and Mental Illness to Vitality#266: Prescribing Poisons Part 2. Ibuprofen, PPI's, and Flouroquinalone AntibioticsVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Ibuprofen, acetaminophen, and aspirin — there are many over-the-counter pain medications available, but are they all the same? And how much should you really take? In this episode, a doctor and pharmacists cover your drug options, including side effects, dosage and what to reach for the next time you have a headache or fever.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Ibuprofen, acetaminophen, and aspirin — there are many over-the-counter pain medications available, but are they all the same? And how much should you really take? In this episode, a doctor and pharmacists cover your drug options, including side effects, dosage and what to reach for the next time you have a headache or fever.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Diddy's Lawyer Quits Defense Team (PEOPLE) (24:10)Meghan Markle 'Soaks in the Weekend' on Instagram (PEOPLE) (29:21)Jesus Guerrero, Celebrity Hairstylist, Dies 'Suddenly and Unexpectedly' at 34 (PEOPLE) (37:28)Dolores Catania's son, Frankie Jr., engaged to girlfriend Nicole Perricho (Page Six) (40:14)Sam Nivola Reveals Mike White 'Modeled' His Family in The White Lotus After Bravo's Southern Charm (PEOPLE) (48:26)White Lotus Recap (51:30)Love is Blind Recap (1:00:19)The Toast with Jackie (@JackieOshry) and Claudia Oshry (@girlwithnojob) Lean InThe Camper and The Counselor by Jackie OshryMerchThe Toast PatreonGirl With No Job by Claudia OshrySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode is brought to you by Levels and Fatty15. When we think about long-term health and longevity, nitric oxide production probably isn't the first thing that comes to mind. But today's guest explains why this crucial molecule plays a key role in our bodies—and the tell-tale signs of low production that can ultimately contribute to chronic disease. Today on The Dhru Purohit Show, Dhru sits down with Dr. Nathan Bryan to explore why nitric oxide is the holy grail of molecules for long-term health—and the top lifestyle factors that can make or break its production. Dr. Bryan ranks the biggest disruptors of nitric oxide, including alcohol, poor sleep, a sedentary lifestyle, ultra-processed foods, and chronic stress, and dives into the latest research on how they impact your body. He also breaks down the critical role nitric oxide plays in disease prevention, from chronic illness to Alzheimer's. If you're looking for a masterclass on how to boost nitric oxide production and what habits you need to tweak, this episode is a must-listen. Dr. Nathan Bryan is a renowned biomedical researcher known for his groundbreaking work on nitric oxide (NO) biology. Dr. Bryan's research has significantly advanced our understanding of NO's critical roles in cardiovascular health, immune function, and neurobiology. Beyond academia, he advocates for public health, translating his research into practical solutions for improving human health. His new book is The Secret of Nitric Oxide.  In this episode, Dhru and Dr. Bryan dive into: How alcohol impacts nitric oxide production (00:31) Why nitric oxide is crucial for health (03:12) The dangers of nicotine and smoking on nitric oxide (04:36) The controversy around seed oils (10:17) How dangerous are ultra-processed foods (18:43) How nitric oxide is created and what chronic stress does to production (26:10) Sedentary lifestyle and its impact on health risks (33:39) Nightly desserts and glucose monitoring (42:10) Intermittent fasting and the importance of meal personalization (50:15) Antiseptic mouthwash, bad breath, and the microbiome (54:09) Nitric oxide benchmarks and what test strips measure (58:50) Lack of optimal sun exposure (01:11:57) Eating nitrate-rich foods and carnivore diet concerns (01:15:14) Hydration's role in nitric oxide levels (01:21:27) Ibuprofen, inflammation, and nitric oxide (01:23:11) N101 products and final thoughts (01:29:22) Also mentioned in this episode: Dr. Nathan Bryan's book - The Secret of Nitric Oxide https://www.n101nutrition.com/ Try This-Firefighter Study For more on Dr. Nathan, follow him on Facebook, Instagram, X/Twitter, YouTube, and his Website. This episode is brought to you by Levels and Fatty15. Right now, Levels is offering my listeners an additional 2 FREE months of the Levels annual Membership when you use my link, levels.link/DHRU. Make moves on your metabolic health with Levels today.  Fatty15 is offering an additional 15% off its 90-day subscription Starter Kit. Go to fatty15.com/dhru and use code DHRU to replenish your C15 levels for long-term health. Learn more about your ad choices. Visit megaphone.fm/adchoices

Prednisolone is a corticosteroid that is often used in pediatrics. Hyperglycemia, insomnia, and GI upset are relatively common adverse effects. Ibuprofen is a commonly used OTC pain reliever. It is classified as an NSAID and can increase GI bleed risk and exacerbate heart failure. Aceon is the brand name for perindopril. ACE inhibitors are well known to cause drug induced cough and will cause hyperkalemia. Trazodone is classified as an antidepressant but is frequently used to treat insomnia because of its sedative properties. Pioglitazone is an oral anti-diabetes medication that should be avoided in patients with heart failure.

Nearly all pain relievers on the market use the phrase “for fast, temporary relief.” Aspirin, Ibuprofen, Acetaminophen – they’ll give a little relief, for a little while. But when it comes to forgiveness of our sin, we’re more interest in “immediate, everlasting relief” from our guilt and guile. Today on A NEW BEGINNING, as Pastor Greg Laurie takes us to the story of the first Passover, we’ll see God provided a solution for sin that forever paid the price that had to be paid. Send help and hope to SoCal Listen on harvest.org --- Learn more and subscribe to Harvest updates at harvest.org A New Beginning is the daily half-hour program hosted by Greg Laurie, pastor of Harvest Christian Fellowship in Southern California. For over 30 years, Pastor Greg and Harvest Ministries have endeavored to know God and make Him known through media and large-scale evangelism. This podcast is supported by the generosity of our Harvest Partners.Support the show: https://harvest.org/supportSee omnystudio.com/listener for privacy information.