Podcasts about single nucleotide polymorphisms

URGENT MESSAGE: Denise has generously organised a 20% discount for the first 60 people to purchase her upcoming 28 Day WholeFood Challenge course beginning in January 2024:Use the code: NatMedPodcast20We're born with a genetic blueprint, including some variations we may have acquired along the way. These variations, called SNPs (short for Single Nucleotide Polymorphisms), influence certain characteristics of our DNA blueprint to change gene expression. What we now know is that diet can have effects on gene expression  leading to powerful effects on our health.And what better clinician to lead us through how to master your genes using food, than Dr Denise Furness.Strap in and have the rewind button handy. This is an information-packed podcast!ReferencesMCM6 - lactoseMCM6 is located upstream from the LCT gene, which produces the enzyme lactase required to digest lactose. MCM6 influences LCT and lactase expression.PMID: 11788828, PMID: 12915462, PMID: 15114531HLA-DQ haplotypes - Gluten Human leukocyte antigen (HLA system) encodes the Major Histocompatibility Complex (MHC). These genes code for antigens (proteins) that help cells recognise self versus non-self. Genetic variations within HLA-DQA1 & HLA-DQB1 are linked to coeliac disease and other autoimmune conditions.PMID: 30763397, PMID: 29244800MTHFR FolateMTHFR converts 5,10-methylenetetrahydrofolate (5,10 methyleneTHF) to 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is needed to convert homocysteine to methionine, therefore MTHFR supports methylation (making SAM) reactions throughout the body.MTHFR 677 T allele and increased risk for lower folate and higher homocysteine levels PMID: 25788000, 24091066, 7647779,  9545395 APO-E Alzheimer's, LipidsAPOE's main phenotypes are caused by the combination of two SNPs that combine to form the genotypes/isoforms of ε2, ε3 and ε4 or E2, E3, E4. The E4 allele is associated with higher LDL levels and cardiovascular and neurological complications. PMID: 25328986, PMID: 11882522SLC30A8 - zinc transporterSpecific to pancreatic islets and mainly expressed in β-cells that transport zinc from the cytoplasm into insulin secretory vesicles. Allelic variants have been associated with glucose and pro-insulin levels and confer susceptibility to insulin resistance and diabetes mellitus (T2DM). PMID: 28218639, 17463249, 30936916.FTO and MC4R - weight and obesityFat mass and obesity-associated gene (FTO)Melanocortin-4-receptor (MC4R) PMID: 31954858, 19079261, 26888713

In this episode Dr. Gillian Beauchamp sits down with Dr. Alex Manini to discuss single nucleotide polymorphisms (SNPs) of the Mu receptor and how they may relate to overdose severity of opioid overdose. 

Today we speak with Professor Jann-Yuan Wang, a clinician and researcher in Taiwan, about his work in latent tuberculosis. Professor Wang speaks about his experience using 3HP and the challenges of systemic drug reactions. Professor Wang talks about his research into predicting which patients will experience systemic drug reactions based on research algorithms of clinical characteristics, plasma drug levels and transcriptomic factors.REFERENCES:1) Lee, Ming‐Chia, et al. "Isoniazid level and flu‐like symptoms during rifapentine‐based tuberculosis preventive therapy: A population pharmacokinetic analysis." British journal of clinical pharmacology (2022).2) Peng, Tzu-Rong, et al. "Advantages of short-course rifamycin-based regimens for latent tuberculosis infection: an updated network meta-analysis." Journal of Global Antimicrobial Resistance 29 (2022): 378-385.3) Huang, Hung-Ling, et al. "Whole-blood 3-gene Signature as a Decision Aid for Rifapentine-based TB Preventive Therapy." Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America (2022).4) Huang, Hung-Ling, et al. "Impact of age on outcome of rifapentine-based weekly therapy for latent tuberculosis infection." Clinical Infectious Diseases 73.5 (2021): e1064-e1071.5) Lee, Meng-Rui, et al. "Isoniazid concentration and NAT2 genotype predict risk of systemic drug reactions during 3HP for LTBI." Journal of clinical medicine 8.6 (2019): 812.6) Sun, Hsin-Yun, et al. "Twelve-dose weekly rifapentine plus isoniazid for latent tuberculosis infection: A multicentre randomised controlled trial in Taiwan." Tuberculosis 111 (2018): 121-126.7) Lee, Meng-Rui, et al. "Plasma Concentration of Isoniazid and Single-Nucleotide Polymorphisms of N-Acetyltransferase 2 Predict Risk of Systemic Drug Reactions During Weekly Rifapentine and Isoniazid Therapy for Latent Tuberculosis Infection: A Prospective Observational Cohort Study." Available at SSRN 3297903 (2018).

We are joined again by Dr. Asher Brandt, Professor of Biochemistry at the Saint Joseph University, Connecticut, specializing in psychedelic pharmacology. We discuss a recently published paper about how Single Nucleotide Polymorphisms, (SNPs, pronounced “snips”) might alter the pharmacological signaling of potentially therapeutic psychedelics.SNPs are the most common type of genetic variation among people. Specifically, it's a genomic variant at a single base position in the DNA, which can lead to a single point amino acid mutation in the subsequently synthesized protein.In the study, the authors examined whether sequence variations in the 5-HT2A receptor gene affect the signaling of some of the most used psychedelic drugs such as LSD, mescalin, psilocybin. They examined the in vitro pharmacology of seven non-synonymous SNPs, which give rise to a variant of 5-HT2A serotonin receptors. What they found is that these non-synonymous SNPs exert statistically significant effects on not just the the efficacy but also the potency of four therapeutically relevant psychedelics.What's mind blowing, in our opinion, is that the in vitro pharmacological effects of the SNP drug actions at 5-HT2A receptor are both amino acid and drug specific.References:Schmitz et al. (2022). 5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics. ACS Chem. Neurosci. 2022, 13, 16, 2386–2398.NCBI SNPs Database (dbSNP) url: https://www.ncbi.nlm.nih.gov/snp/

In this episode, Antonia and Andrew discuss a selection of articles from the April 6, 2022 issue of JBJS, along with an added dose of entertainment and pop culture. Listen at the gym, on your commute, or whenever your case is on hold! Articles Discussed: The 1-Year Economic Impact of Work Productivity Loss Following Severe Lower Extremity Trauma, by Levy et al. Aspirin Is an Effective Prophylaxis for Venous Thromboembolism in Ambulatory Patients with Femoral Neck Fracture Undergoing Hip Arthroplasty, by Chisari et al. Risk of Revision After Arthroplasty Associated with Specific Gene Loci. A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 Twins Treated with Arthroplasty, by Brüggemann et al. The Spillover Effect of the Medicare Mandatory Bundled Payment Program on Joint Replacement Outcomes. Analysis of Patients with Commercial Insurance and Medicare Advantage, by Kim et al. Percutaneous Screw Stabilization of Non-Periacetabular Pelvic Lesions Caused by Metastatic Cancer and Multiple Myeloma, by Yang et al. Predicting Patient Loss to Follow-up in the STABILITY 1 Study. A Multicenter, International, Randomized Controlled Trial of Young, Active Patients Undergoing ACL Reconstruction, by Firth et al. The Utility of a Novel Proximal Femur Maturity Index for Staging Skeletal Growth in Patients with Idiopathic Scoliosis, by Cheung et al. Conversion of the Sagittal Functional Safe Zone to the Coronal Plane Using a Mathematical Algorithm. The Reason for Failure of the Lewinnek Safe Zone, by Tang et al. Link: JBJS website: https://jbjs.org/issue.php Sponsor: This episode is brought to you

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.14.382739v1?rss=1 Authors: Ali Hassan, A., Ibrahim, M. E. Abstract: Chemokines are small transmembrane proteins with immune surveillance and immune cell recruitment functions. the expression of CCR5 gene affects virus production and viral load(1). The CCR5 gene contains two introns, three exons, and two promoters, and it is necessary as a co-receptor for the entry of the macrophage-tropic HIV strains. Mutations in the coding region of CCR5 affect the protein structure, which will affect production, chemokine binding, transport, signaling and expression of the CCR5 receptor. SNPs within CCR5 gene were retrieved from ensemble database. Coding SNPs were analyzed using SNPnexus. Coding non-synonymous SNPs in CCR5 binding domains with Viral gp120 were analyzed using SIFT, PolyPhen and I-mutant tools. Project HOPE then used to modelled the 3D structure of the protein resulting from these SNPs. Non-coding SNPs that affects miRNAs in 3' rejoin were analyzing using PolymiRTS. SNPs that affect transcription factor binding were analyzed using regulomeDB. (178) non-synonyms missense SNPs were found to have deleterious and damaging effect on the structure and function of the protein. In CCR5 binding domains with Viral gp120: 3 SNPs rs145061115, rs199824195 and rs201797884 were found to affect both structure and function and stability of chemokine protein. The 2 SNPs rs185691679 and rs199722070 has a role in disruption and creation of the target sites in miRNA seeds due to their high conservation score. Mutations in CCR5 gene may explain and represent the molecular basis of the resistance to HIV infection. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.241976v1?rss=1 Authors: Fadl, H. A. O., Abdelmoneim, A. H., Elbager, S. G. Abstract: ABSTRACT Background: CLL: Chronic lymphocytic leukemia is a chronic type of haematological malignancies that evoked from lymph proliferative origin of bone marrow and secondary lymphoid tissue, resultant in proliferation and progressive accumulation of distinct monoclonal CD5 /CD19 /CD23 B lymphocytes in the bone marrow, peripheral blood, and lymphatic organs. CD38 is a multifunctional ecto-enzyme, known to be a direct contributor in pathogenesis of CLL by poorly understood mechanism. Even though , it highly expressed in CLL. At specific position of CD38 gene sequence, substitution of single nucleotide may result in change in amino acid that ends by consequent alteration of protein structure. Aim: To study CD38 polymorphism and to predict its effect on structure and subsequently function of CD38 molecule. Methodology and Result: The bioinformatic analysis of CD38 gene had been carried out by using several soft wares. Functional analysis by SIFT,Polyphen2, and PROVEAN reveled 12 deleterious SNPs. These SNPs were further analyzed by SNAP2, SNP@GO. PMut, STRING and other soft wars. Furthermore, Stability analysis was done using I-Mutant and MUpro software where seven SNPs were found to decrease the stability of the protein by I-Mutant ,while two SNPs increase it. At the same time, eight SNPs were found to decrease the stability by Mupro software while only one SNP is predicted to increase it. Finally, Physiochemical analysis was done using Project Hope. Conclusion: In summary, CD38 genotype seems to have twelve SNP that possibly will result in deleterious effect on Protein Structure. This genetic variation eventually will lead to alteration in potential molecule functions .Which effect the progression of CLL By the end. Keywords: B-Chronic lymphocytic leukemia, missense single nucleotide polymorphism, and CD38 gene. Copy rights belong to original authors. Visit the link for more info

Dr. Daniel Claassen discusses his paper,  "Genotyping Single Nucleotide Polymorphisms for Allele-Selective Therapy in Huntington Disease". Show References: Paper: https://ng.neurology.org/content/6/3/e430 Podcast: https://neurology.libsyn.com/website

When it comes to taste, we all have our favourites. Some prefer the savoury to the sweet, while others love the salty. Some seem to pull out these incredible notes from a wine while others struggle for a description other than good. Even with our kids, some will like anything while others will fight against everything. Why is that? How our taste buds work along with our sense of smell is a fascinating discussion, but so is the idea you can get your kids to like more things if you are willing to keep pushing new foods. And you yourself can become better at describing those tastes and flavours. It's all in this episode with our guests: Bob Holmes: http://bobholmes.org/blog/ Elie Chamoun: https://www.researchgate.net/publication/326709679_The_Relationship_between_Single_Nucleotide_Polymorphisms_in_Taste_Receptor_Genes_Taste_Function_and_Dietary_Intake_in_Preschool-Aged_Children_and_Adults_in_the_Guelph_Family_Health_Study --- Send in a voice message: https://anchor.fm/foodbubble/message

Dr Chad: 00:00 This is Dr Chad Edwards and you’re listening to podcast number 89 of against the grain. Welcome back to the against the grain podcast. This is Dr Chad Edwards and I am here with the lovely Diana. Good to be here and we are finally back recording. We’re podcasting. We’ve got some […] The post Episode 89 – Single Nucleotide Polymorphisms (SNPs) appeared first on Revolution Health & Wellness.

[NOTE: We had a publishing error last week and most subscribers missed Episode 61 with Jamaica Stevens on Crisis, Rebirth, and Transformation! Definitely worth going back to listen to this awesome chat.]David Krantz is a personal nutrition and genetics coach, sound therapy technician, and electronic music producer based in Asheville, NC. http://david-krantz.com Subscribe to this show:Apple Podcasts • Stitcher • SpotifyJoin our Facebook Discussion Group This week we chat about genetics – specifically how different gene variations in people affect the way we experience cannabis. We’re coming up on a revolution in biotech and agriculture that will soon make it a possibility to grow gene-tailored strains of cannabis to suit YOUR DNA specifically…until then, though, here is your primer on how to dance with Mary Jane in ways that work WITH, not AGAINST, you.(David is a repeat guest from Future Fossils Episode 0010, when he chatted with us about the future of electronic music, plant intelligence, and tripping with cats and modular synthesizers. Be sure to check that one out also!) We Discuss: • CYP2C9 - a liver enzyme that breaks down THC - and how the amount your body produces will determine how high you get from edibles, your ability to pass a drug screening, etc.• How learning about our genetic differences helps us develop tolerance and acceptance of each other’s very different needs and bodies• COMT, a gene responsible for dopamine breakdown, and how which variant of this gene you possess determines cannabis-induced memory loss and alteration of time perception• ATK1, a gene whose variants determine how “psychotomimetic” (ie, trippy) your response to cannabis will be, and whether or not it will exacerbate schizophrenic symptoms• How it is, and isn’t, helpful for the law to regard cannabis primarily as a medicine• APOE, a gene that heavily influences Alzheimer’s Disease, not in isolation but depending on whether or not you eat a lot of saturated fats or exercise• How we must revolutionize education and accreditation in an age of digital learning, so that we can deploy as much healing intelligence as possible• Single Nucleotide Polymorphisms, or SNPs, and how these one-letter changes in a gene can make a huge difference• David’s critique of cannabis studies that DON’T break down research subject populations down into genetic subgroups, and reveal the researchers’ biases• The need for “cultural interoperability” in our discussions about cannabis research, “across the aisle” between scientists for and against its legalization• AND Coffee and Chaga mushrooms and more – enacting complex mutually supportive benefits• Which gene tests David likes best, and best practices for privacy with your genetic data• The future of genomic science’s influence on cannabis horticulture and use Quotes: “There are probably some people that shouldn’t smoke weed.” “I feel very qualified to help the people that I’m helping, and having the red tape of, ‘You have to be a medical professional or you can’t talk about this stuff at all,’ doesn’t make sense for where we’re going – because I can listen to 2000 hours of podcasts, like I did when I was working at Moog, and feel like I’ve really upped my understanding of some things. Maybe that can help other people besides myself.” “I’ve become increasingly self-aware of the way I feel about people who disagree with me…” “There’s no such thing as the perfect human diet.” Related Links: Kerri Welch on dopamine and time perception https://textureoftime.wordpress.com/2015/08/30/dopamine-and-traction-between-internal-and-external-time/ See acast.com/privacy for privacy and opt-out information.

Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. SNP - single nucleotide polymorphisms There is great heterogeneity between individuals in their risk of developing cancer, disease progression and responses to therapy. Specific single nucleotide polymorphisms (SNPs) are associated with human cancers. They have the potential to help us identify individuals more at risk of developing cancer, and better target preventative or therapeutic strategies.

Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. SNP - single nucleotide polymorphisms There is great heterogeneity between individuals in their risk of developing cancer, disease progression and responses to therapy. Specific single nucleotide polymorphisms (SNPs) are associated with human cancers. They have the potential to help us identify individuals more at risk of developing cancer, and better target preventative or therapeutic strategies.

Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. SNP - single nucleotide polymorphisms There is great heterogeneity between individuals in their risk of developing cancer, disease progression and responses to therapy. Specific single nucleotide polymorphisms (SNPs) are associated with human cancers. They have the potential to help us identify individuals more at risk of developing cancer, and better target preventative or therapeutic strategies.

Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer. SNP - single nucleotide polymorphisms There is great heterogeneity between individuals in their risk of developing cancer, disease progression and responses to therapy. Specific single nucleotide polymorphisms (SNPs) are associated with human cancers. They have the potential to help us identify individuals more at risk of developing cancer, and better target preventative or therapeutic strategies.

This podcast covers the JBJS issue for August 2014. Featured are articles covering: Nonsurgical or Surgical Treatment of ACL Injuries; recorded commentary by Dr. Fithian; Evaluation of AAOS Guidelines on Prophylaxis of VTE in Total Joint Arthroplasty; recorded commentary by Dr. Devitt; Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing; Soft-Tissue Allografts Terminally Sterilized with an Electron Beam Are Biomechanically Equivalent.

This podcast covers the JBJS issue for August 2014. Featured are articles covering: Nonsurgical or Surgical Treatment of ACL Injuries; recorded commentary by Dr. Fithian; Evaluation of AAOS Guidelines on Prophylaxis of VTE in Total Joint Arthroplasty; recorded commentary by Dr. Devitt; Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing; Soft-Tissue Allografts Terminally Sterilized with an Electron Beam Are Biomechanically Equivalent.

Fri, 1 Mar 2013 12:00:00 +0100 https://epub.ub.uni-muenchen.de/22768/1/22768.pdf Buzas, E. I.; Gabius, Hans-Joachim; Falus, A.; Molnar, M. J.; Bovin, N. V.; Kaltner, H.; Nagy, G.; Gordeeva, E.; André, S.; Gal, J.; Srivastava, S. K.; Antal, P.; Pal, Z. ddc:

Background: The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences. Methodology/Principal Findings: Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847). Haplotype and genotype-phenotype analyses were performed. The SNPs rs2066843 (p = 3.01×10−5, OR 1.48, [95% CI 1.23-1.78]) and rs2076756 (p = 4.01×10−6; OR 1.54, [95% CI 1.28-1.86]) were significantly associated with CD but not with UC susceptibility. Haplotype analysis revealed a number of significant associations with CD susceptibility with omnibus p values

Runtime 23:52 Medical oncologist Kenneth Offit explains inherited mutations, hereditary disease, and its influences on cancer. read more

In episode one of these potentially life-changing Breather shows, I talk about insights from Dr. Bruce Lipton’s transformative book called The Biology Of Belief ( https://www.amazon.com/Biology-Belief-10th-Anniversary-Consciousness/dp/140195247X/ref=sr_1_1_sspa?keywords=Biology+Of+Belief&psc=1&qid=1561051693&s=gateway&sr=8-1-spons ). Here is the foundational premise that will blow your mind: By age 35, 95-99% of your thoughts and actions originate from the habitual programming of the subconscious mind, mostly happening from ages 0-6 when we absorb our environmental happenings like a sponge. This is a combination of memorized behaviors, emotional reactions, beliefs and perceptions, that run in the background like an app on your smartphone. Brain scientists report that *we think between 12,000-60,000 thoughts per day,* that *98% of them are identical to yesterday’s thoughts,* and that *80% of your subconscious thoughts are negative.* Are you pleased to hear this insight? Personally, I was pretty disturbed, because I prefer to think of myself as a mindful, conscious person. Actually, we are literally sleepwalking through life, reacting and getting stuck in patterns. It’s time to change, and it takes only a couple Breather shows! This book is a groundbreaking work in the field of new biology, and it will forever change how you think about thinking. Through the research of Dr. Lipton and other leading-edge scientists, stunning new discoveries have been made about the interaction between your mind and body and the processes by which cells receive information. It shows that genes and DNA do not control our biology, that instead DNA is controlled by signals from outside the cell, including the energetic messages emanating from our thoughts. Dr. Lipton explains that we spend 95-99% in daily life operating from subconscious programming. This programming happens when we’re “open” (ages 0-6). At that age, we are like sponges, absorbing every little bit of information from our environments: yes, all the family dysfunction, teachers scolding and criticizing, but we retain the good things too. By 6, we are fully programmed, and as we live and age, we continue to engage in behaviors aligned with our subconscious programming from ages 0 to 6. When we’re told we are not good enough, we play that out with 95 to 99% of our behaviors controlled by the subconscious mind, which is fully programmed by the time we’re 6 years old (something I touched on when I discussed parenting in part 2 ( https://www.bradkearns.com/2018/12/21/sivander2/ ) of my show with Gitta Sivander). So what happens when you’re out of the super sensitive, sponge-absorbing-everything stage? You’re an adult, past programming, and like everyone else, working on sorting through and unloading all the baggage you’re still carrying around from childhood...and maybe you go to therapy to try to work it out. One important thing to note about therapy, though: Dr. Lipton believes that when you repeat and relive these traumatic stories in therapy, your physiology is reliving them as well, which is why he offers alternative ways to heal from these traumas. To understand Dr. Lipton’s book, it’s crucial to understand that *genes are controlled by epigenetic influences that are mediated by our perception of these environmental influences.* A good example is a traffic jam: I can easily sink into the mentality of: “Oh no, I hate traffic jams, what a F@^&$G waste of my time, I am SO mad!,” I can be honking my horn angrily, anxiously looking over at the next lane to see if I can squeeze myself in there and save an extra 12 seconds...or I can be like, “Well, ok, it looks like I’m stuck in a traffic jam, and I’m going to be a little behind schedule…” and I can take a deep breath, go with the flow, put on some classic music or a podcast, relax, and just go with it. The difference between these two outlooks is huge, and there is a massively different impact on your genetic health, your biology, and your hormones when you are completely in control of your thoughts in reaction to your environment. I have a future show coming up with Dr. Ron Sinha where he talks about how his practice is really focusing in on how *rumination is a disease* that manifests with all kinds of physical problems. The moment you go into rumination you start worrying about the past or the future, and then you are operating from the  subconscious mind — and that does not support you — not when *80% of our ruminating thoughts are negative.* You have to learn how to interact with your thoughts and change them in real time, by becoming mindful, and by *taking control* — this is especially important during a time when people so easily say, “you triggered me.” This is something I discussed on the show with Mia Moore ( https://www.bradkearns.com/2018/09/11/mia-moore-small-stuff/ ). It’s easy to be triggered - but where does that leave you? Powerless. Take control when you feel yourself reacting to something negatively. Then you activate the conscious to reprogram your subconscious. Unfortunately, life is way too hectic to allow us to do so, and our minds are too full to sit in quiet reflection and realize the significance of our thoughts and our subconscious programming, so Lipton suggestions these methods to become more conscious: * Meditation * Clinical hypnosis * Plant medicine trip * Energy psychology using EMDR (this helps us change self-limiting beliefs by slowing down our thoughts) So, what is one area of life that reprogramming your beliefs will directly affect? *LONGEVITY*. Mental flexibility is one of the four pillars of longevity (to be explained further in the Keto Longevity book coming Fall 2019!). The 5 communities that are home to longevity superstars? * Okinawa, Japan. * Loma Linda, California. * Costa Rica's isolated Nicoya Peninsula. * Ikaria, an isolated Greek island. * The Italian island of Sardinia. What do all these people have in common? A *youthful psychological age*. There are significant scientific studies that support the idea that we have not one, but *three relevant ages* toward our longevity: * Chronological age (the year you were born) * Psychological age (how old you feel) * Biological age (the state of your physical health) We make so many associations and attachments to chronological age that don’t serve us, and the reality is that science has revealed that *your biological age and psychological age are vastly more important to your longevity prospects*. This is something Deepak Chopra has discussed - how cultivating a youthful spirit, and the accordant beliefs that support it, can be manifested into reality on a quantum physical level. In Dr. Chopra’s landmark 1993 book, Ageless Body, Timeless Mind , he corrects our flawed layman’s notion that we are physical beings separate from the world around us. What we perceive as our physical body — head, shoulders, knees and toes — is literally *a swirling mass of atoms* that are constantly dying and renewing based on signals received from the environment. This means that we have the power, at all times, to influence gene expression and cellular function through the thoughts that we think, the foods we eat, the movement we engage in, and so forth. In The Biology of Belief, Dr. Lipton says, ** *“The function of the mind is to create coherence between our beliefs and the reality we experience.* *Your mind will adjust the body’s biology and behavior to fit your beliefs* *. If the perception in your mind is reflected in the chemistry of your body, and if your nervous system reads and interprets the environment and then controls the blood’s chemistry, then* *you can literally change the fate of your cells by altering your thoughts.”* However, most of us are way too maxed out with stressing, obsessing, ruminating, and complaining to even begin to ponder evolved concepts like influencing cellular function with our thoughts. The Biology of Belief makes you realize that your swirling mass of atoms is literally floating through hectic modern life in a daze, but only if you let this happen. Like Dr. Lipton said, you can literally change the fate of your cells by altering your thoughts. Another great quote from the book: *“The subconscious mind has the tendency to interfere with our conscious desires by programming undesirable thoughts and behaviors, which could lead to a great deal of stress and turmoil in our lives.”* As dysfunctional childhood programming takes plays out, we adopt an assortment of narrow, flawed, and self-limiting beliefs. It’s common to believe that our genes are fixed heritable traits from our parents, and that they will largely determine our health destiny. You may have a family history of heart disease, obesity, breast cancer, depression, an impatient temperament, flat feet, or whatever else: yes, you are bestowed with these curses from your similarly-endowed parents and grandparents, and can’t do much to alter your course. Of course this stuff is relevant and important, but never forget that *you have all the power*. Otherwise, having a destructive, fixed mindset is the quickest way to ensure it WILL come true. This book reinforces that idea that your destiny is in your hands. The glass half empty saying has literal significance — this line of thinking is known as genetic determinism , whereby genes are erroneously believed to be self-actualizing. As Dr. Lipton explains in The Biology of Belief , the concept of genetic determinism has been completely refuted by recent discoveries in the field of epigenetics — the study of how environment influences gene expression *. In the reality we create with mental flexibility, virtually every genetic and hormonal function that influences health and longevity is a product of environmental signals combined with your perception of those signals.* We all know senior citizens who are cranky and lonely, as well as those who are vibrant and happy. This is not random distribution of genetic good fortune, but rather a product of intention and execution. Dr. Chopra describes this as, *“expectations determining the outcome.”* Granted, some people really are blessed with genetic variations (known as Single Nucleotide Polymorphisms, or “SNiPs) that promote enhanced cellular repair. One study revealed that a group of centenarians aged 100-107 had higher levels of two specific DNA repair enzymes than a group of random seniors aged 69-75.  The less fortunate may have ordinary genes, and more destructive beliefs and traumatic life experiences to overcome in order to embrace new possibilities. However, *regardless of the cards you have been dealt* , a grand new vision for your life journey is within your reach, starting with the formulation of empowering new beliefs. Here are Dr. Chopra’s marching orders accordingly: “ *By cultivating the habit of thinking of your body as a field of energy, transformation, and intelligence, you will begin to experience it as a flexible, dynamic bundle of consciousness, rather than a fixed, material thing.”* But it is also important to note Dr. Lipton’s argument that believing that genes are self-actualizing is akin to thinking you can take an architect’s set of blueprints, toss them into the dirt on your empty lot, and expect the blueprints to build your dream house by themselves. Stretching the metaphor further for a moment, if you toss your precious blueprints into the dirt of your magnificent lakefront lot and sit back and wait, they will eventually get destroyed by mud, rain, sleet, and snow. Similarly, sitting around all day while your genes expect and desperately crave movement, or staying up late into the night when your genes crave darkness and sleep, will result in the destruction of healthy cells. One of the most important things you can do for yourself is to practice mindfulness, especially with your thoughts, and The Biology of Belief is an amazing tool you can use to truly understand how you can work with your mind-body connection to empower yourself to take control of your life by being in control of your beliefs. *TIMESTAMPS:* We spend 95 to 99% of our time in daily life operating from subconscious programming. [04:41] Programming happens between ages 0 to 6. [05:50] You can interact with your thoughts and change them in real time by becoming mindful. You can reprogram yourself. [10:36] How does the mind affect longevity? [14:56] The function of the mind is to create coherence between our beliefs and the reality that we experience. [22:00] Genes don’t determine our destiny, but rather our behaviors. [26:24] Support this podcast at — https://redcircle.com/the-get-over-yourself-podcast/donations Advertising Inquiries: https://redcircle.com/brands