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Keith Murphy and Andy Fales make their debut on the Iowa Everywhere network alongside their producer Andrew Downs to recap Iowa and Iowa State's weekend, Caitlin Clark's takeover, and catch up from their break. Quickie Poll, AD2, and More all make their return. Courtesy of Ramsey Subaru and BMW of Des Moines. Learn more about your ad choices. Visit megaphone.fm/adchoices
Francisco Javier Ramírez Vázquez, Fundador SNI Salud y Nutrición Integral. Estudió para medico veterinario Zootecnista en la Universidad de Zacatecas, asi mismo cuenta con una especialidad en Producción Animal (cerdos) por la UNAM. En 2021 se graduó del IPADE en AD2, Alta Dirección Originario de La Piedad, Michoacán. Entre sus principales hobbies destacan: leer, viajar y Cata de vinos, innovador, siempre buscando el aprendizaje con capacitaciones y estudios. Disfruta de la naturaleza y el senderismo. En 2003 fundó junto a su familia la empresa SNI (Salud y Nutrición Integral), dedicada a la salud animal, donde brindan nutrición, medicamentos, desinfectantes, equipos de orientación, servicios de consultoría. Donde su principal compromiso es comercializar productos y servicios de alto valor para la producción pecuaria. Actualmente tienen presencia en Guanajuato, Aguascalientes, Jalisco, San Luis Potosí y Querétaro. Buscando la expansión de su red de distribución y la importación de productos innovadores. Contacto: Sitio Web SNI: https://snintegral.com Facebook SNI: https://www.facebook.com/snisaludanimal/ LinkedIn: https://www.linkedin.com/in/francisco-javier-ramirez-vazquez-42574484/
Andy Fales is joined by Emery Songer and they go through Trending Iowa and the weird and wacky sports topics in the world right now. They chat about their favorite stoner movies with Mr. Movie and he reviews some new releases. The show wraps up with a potty mouth edition of AD2.
Murph and Andy are joined by Scott Siepker and they finish recapping the Iowa men's basketball season. They also talk about when "Peeps" season is and the St. Patrick's Day Parade in Des Moines. They go through a basketball edition of Scott School and "More!" as Iowa State gets off to a very bad start in their NCAA Tournament game. They finish the show with the AD2.
Murph and Andy tackle some of the big topics in Iowa as the NCAA Tournaments get underway. They check in with Sean Roberts at Buzzard Billy's for what the atmosphere has been like downtown. Drake Men's Basketball Play-by-Play Broadcaster Michael Admire joins the show to talk about why he's not with the team this weekend. They finish with the AD2 and Quickie Poll results.
Murph and Andy are at the Confluence Tap Room and they talk about some of the trending topics in Iowa at the start of the NCAA Tournament. They also grind through another edition of "Guess Whose Birthday?" They also chat with Mr. Movie and talk about their favorite beer scenes in a movie and review some recent movies. They finish with the AD2.
Murph and Andy chat about a variety of Iowa related topics and then revisit a conversation from yesterday's "More!" to determine which person is most at fault in a strange conundrum. They also chat with our friends at Confluence Brewing about the release of "Downtown Throwdown" happening tomorrow. They finish the hour with "More!" and AD2.
Murph and Andy breakdown various bracket scenarios and recap Iowa State and Drake winning their conference's women's tournaments over the weekend. They get stumped by "Guess Whose Birthday?" with Emery and run through More! They finish the show with a World Baseball Classic edition of AD2.
Murph and Andy go through Trending Iowa and talk at length about the darkness retreat that Aaron Rodgers just wrapped up. They also review Brock Purdy's injury situation. They go through "More!" and finish with an XFL edition of the AD2.
Murph and Andy talk about a movie that Murph watched about Joe Bell and what he got out of it. They go through the 2 PM Trend and talk about their love of block parties. They talk through More! including foods people still hate as adults. They finish with the AD2 from Skip Bayless and Shannon Sharpe arguing about arguing.
Murph and Andy go through some of the big stories from Iowa in the 2 PM Trend, then talk about their experience hosting Cy's House of Trivia. They talk about the USFL kicking off this upcoming weekend as well. Andy runs through some More! and Emery Songer plays the AD2.
Murph and Andy talk through the 2 PM Trend and debate whether Aaron Rodgers or Russell Wilson has more pressure on them going into next season. They also run through the best Batmans and a review of "The Batman" from Mr. Movie. They finish the show with a groovy AD2.
Murph and Andy talk about some of the latest local topics during the 2 PM Trend before digging into the season-long suspension for Falcons wide receiver Calvin Ridley for gambling. They play "Guess Whose Birthday?" then run through some "More!" including a job that you can make money by switching your dog's food and smelling their poop. They finish the show with the AD2.
Andy Fales is joined by Emery Songer and they run through some basketball headlines in Iowa. Winterset Activities Director Randy McDonald calls in to give an update on how his community is dealing with the aftermath of the tornadoes this weekend ahead of the boys' state basketball game they play on Tuesday. Andy goes through More! including National Cereal Day. They finish the show with the AD2.
Hunter, Trevor, and Konner break down the All-Star Weekend.Subscribe ► http://bit.ly/FoundationPodcastsCheck out the Store: http://foundationdiscs.comWebsite: http://FDNSports.comPatreon: http://patreon.com/foundationdiscgolfFoundation Disc Golf: http://youtube.com/foundationdiscgolfFoundation Nation: http://youtube.com/foundationnationchannelDisc Reviews: http://youtube.com/c/FoundationDiscGolfReviewsJoin our Facebook group: http://facebook.com/groups/3172497701649450:00 - Intro and Ad2:32 - Announcement4:40 - All-Star Weekend33:55 - Where was UDisc?43:51 - Trevor's Trivia49:22 - Hunter's Thoughts57:21 - College Disc GolfFollow Us:http://instagram.com/foundationdiscgolfhttp://twitter.com/foundationdghttp://facebook.com/foundationdiscshttp://discord.gg/foundationdiscgolfhttp://reddit.com/r/FoundationDiscGolfSupport the show (https://patreon.com/foundationdiscgolf)
Murph and Andy go through a round of the 2 PM Trend before talking about the USA Gymnastics Settlement and the weird NBA and NHL COVID-19 protocols that have cancelled some games. They run through "More!" highlighting some movies that have been added to the National Film Registry. AD2 features a potential bath of mayonnaise.
Murph and Andy go through the 2 PM Trend, including a conversation about Oktoberfest. They also go through the list of Andy's All-Time Charity Case Teams in the major sports. They also go through More! including an interesting story about some bowhunters who say they saw two Bigfoots fighting. Finally, they do the AD2 about Peyton Manning describe "Value Meal plays."
Murph and Andy break down the Iowa and Iowa State performances and another great week for Iowa High School Football in the 2 PM Trend. They go through some of the other big stories in sports and Andy goes through More! including National Punch Day. They finish with a painful AD2 for Viking fans.
Keith Murphy and Andy Fales discuss some of the big local stories in the 2 PM Trend. They also talk about the Olympics and what they would grade the Games as a whole. They go through More! and that includes a world record for a large mouth. They finish the show with AD2.
Keith Murphy and Andy Fales talk about the big day of storms around the state of Iowa. They go through more of Trending Iowa. They talk about the Richard Sherman story and the dispatch audio. They go through More! and the AD2.
Murph and Andy are joined by Scott Siepker, who helps you Betcha House. The guys talk through topics in Trending Iowa and debate the best hangover cures. Andy takes us through MORE and Emery gives a historic AD2.
Murph and Andy kick off the second hour talking Trending Iowa with the All-Americans in the state of Iowa, Drake basketball and the incoming winter storm. Fales chats Christmas presents and after the Play of the Day he gets into More! More! covers National Card Playing Day and all the hidden meaning in a deck of cards and "Cobra Kai" coming out with their newest season early. The AD2 has some NFL audio with the home team cheering on their team to lose and we end the program recapping the stupid Quickie Polls.
Murph and Andy are joined by Scott Siepker to talk about the top topics in Iowa. They are joined by Mr. Movie to make their picks for the Ellis Award and hear about the new releases in film. They finish the show hearing Kevin Durant's interesting interview with Inside the NBA on TNT for AD2.
The periods of Church History from Revelations:1. The Church at Ephesus/Loveless Church: 33 AD-100 AD2. The Church at Smyrna/Persecuted Church: 100 AD-312 AD3. The Church at Pergamos/Compromising Church: 312 AD-606 AD4. The Church at Thyatria/Corrupt Church: 606 AD-1520 AD5. The Church at Sardis/Dead Church: 1520 AD-Tribulation Period6. The Church at Philadelphia/Faithful: 1750 AD-Rapture of the Church7. The Church at Laodicean/Lukewarm Church: 1900 AD-Tribulation PeriodSupport the show (https://www.patreon.com/Keepingitbiblical?fan_landing=true)
Trending Iowa kicks off the hour before Mr. Movie joins the program and before his movie reviews the guys discuss their favorite opening scene to a movie. Jackie Robinson factors in to the Play of the Day ahead of former WHO TV "Today in Iowa" anchor Brooke Bouma chats with the guys as the surprise guest of the day. Then Joe Exotic basketball is the AD2 before the guys close out the show with the Royal Mile inbox and results of the Quickie Poll to end the show.
David Williams, CEO at Advanced Dental Designs, shares his story in transitioning into the Dental Industry and his work as CEO of Advanced Dental Designs these last 10 years! GEAR / MERCHhttps://www.facebook.com/pg/LabMediaTV/shop/APPLE: https://podcasts.apple.com/us/podcast/dental-today/id1465618971STITCHER: https://www.stitcher.com/podcast/dental-todaySPREAKER: https://www.spreaker.com/show/3536635Follow David and AD2: https://www.facebook.com/AD2-Advanced-Dental-Designs-227475420622803/https://www.instagram.com/dave_n_lisa_ad2Follow us: https://www.facebook.com/labmediatv/https://www.instagram.com/labmediatv/ https://twitter.com/labmediatv Music by: Audiobinger https://www.audiobinger.net/ https://www.youtube.com/audiobingerThe podcast is available on Apple Podcasts, STITCHER and Spreaker!!
The guys cover Trending Iowa, Murph throws a Quickie Poll on the fly asking of people want to see Robert Kraft's sex video, Guess Whose Birthday, More! covers Dave Matthews Band recording a live album in Iowa, Iowa dropping from 1st to 14th ranked state, Mickey Mantle's 500th home run, and the AD2 is an employee stepping up for possibly the worst national anthem ever
野崎あいかさんが裏フューチャーにも登場!! どきどきの生放送も無事に終わり、少しほっとした様子。 まさかの麻希さんをミツバチラジオに送り込む!? 「…ちゃこ何食べてんの?」AD2人からの差し入れでした~!
Scott Siepker joins the guys, Call your shot, more, AD2 and more.
Trending Iowa, More, AD2 and more.
Scott Siepker joins the guys live from Hackfest, Trending Iowa, Friday Exit Poll, AD2 and more.
Stump Seany Janks, Mr. Movie, AD2 and more.
Pickle Beer, More, AD2 and more.
Trending Iowa, More, AD2 and more.
Murph and Andy talk trending Iowa, more, AD2 and more.
Andy and John Sears talk Trending Iowa, AD2, and more.
Scott Siepker joins the guys, AD2 and more.
Scott Siepker in, AD2, Siepker's Presidential Trivia, and more.
Trending, Best movies from 1986, AD2 and more.
USA Gymnastics, More, AD2 and more.
Andy talks with Drake AD Brian Hardin, plus Movies with Mike Woody and the AD2
Murph and Andy talk NFL and more, plus Good Call Bad Call and the AD2
Today I interview Jennie Tacheny!Jennie's Bio:Background in print journalism, copywriter by default. I've worked for national brands like Best Buy, Room & Board, Target, Hand Made Modern and Kid Made Modern. And I've been lucky enough to work at the local level too, with brands like Bespoke and other small business owners. I'm also a volunteer copywriter with the Ad2 event/social committee, run an online vintage furniture/decor shop on the side and volunteer with local dog rescues and pet orgs like Secondhand Hounds. Live in St. Paul with my husband and our two literary-named dogs, Austen & Emma.LinksFacebook: facebook.com/wandermn ; facebook.com/jennie.tachenyinstagram.com/jausten512 ; instagram.com/shopwandermnJenna Redfield is the leader of the Twin Cities Collective, the largest resource in the Twin Cities for bloggers, small businesses, entrepreneurs & creatives. She is a well-known speaker, educator & social media strategist. You can work with her one on one with coaching or take one of the Academy classesFree Social Media Masterclass www.twincitiescollectiveacademy.com/masterclass-signupInstagram Marketing Class www.twincitiescollectiveacademy.com/instagramAcademywww.twincitiescollectivacademy.comJoin the Facebook Group https://www.facebook.com/groups/twincitiescollectiveCoaching https://www.twincitiescollectiveacademy.com/coaching-programsFind the podcast on all platforms http://www.twincitiescollective.com/podcast-linksFollow us on Socialhttps://www.instagram.com/twincitiescollective
Lets look at the world and the events of the day and discuss them without concern for offense. Political Correctness is the disease the permeates our society and makes communication between us problematic. If we remain divided we will surely be destroyed. With Election Day, Nov 4th 2014, closing in, and local government taking the point once again for most of us. We meet today with Assemblyman John Hambrick, AD2 of Nevada, to discuss the events of the legislature, concerns for the future and longterm goals of a state that that continues to redefine itself under the shadows of its bigger sisters. Join me today for a no holds barred conversation. Politically Incorrect with Warren Markowitz, Its My World You Just Live In It. Podcasts at Galtspeaks.com Radio@galtspeaks.com Twitter.com/radiomarkowitz Facebook.com/radiomarkowitz Spreaker-http://www.spreaker.com/user/radiomarkowitz Support the podcast, use the next level of autononmy, cryptocurrency: BTC: 1Azen7A8rsEwQ84SCB3ZsbuYALpNCGgqNc
Matt West in conversation with Miwk author Andy Davidson http://miwkpublishing.com/uploads/MIWK_PC_15_AD2.mp3
Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 01/06
Human adenoviruses (Ads) have evolved elaborate mechanisms to counteract the host’s antiviral immune response. The early transcription unit 3 (E3) of the virus is not essential for virus replication in vitro, but is known to encode proteins with immunomodulatory functions. The Ad2 E3/10.4-14.5K proteins are both integral membrane proteins, which form a physical complex and function together to modulate cell surface expression of the EGFR and selective members of the TNF/NGF receptor superfamily, namely Fas/CD95 and TRAIL-R1, whereas TRAIL-R2 modulation additionally requires E3/6.7K. In a process referred to as receptor down-regulation, 10.4-14.5K relocates receptor targets from the cell surface to lysosomes for degradation. The aim of this study was to characterize functional determinants within the Ad2 10.4-14.5K proteins, that are required for down-regulation of plasma membrane receptors. In particular, I focussed on the characterization of potential transport motifs present in the cytoplasmic tail of both proteins: The Ad2 14.5K tail contains three YXXF sequence motifs (Y denotes tyrosine, X any amino acid and F a bulky, hydrophobic residue) while the Ad2 10.4K sequence displays two consensus elements of the second large class of transport signals, the dileucine motifs. Both types of motifs are recognized by cellular adaptor proteins which select cargo for directed transport in clathrin-coated vesicles. FACS analysis of stable E3-transfectants expressing 10.4-14.5K mutant proteins revealed that residues contained within these putative transport motifs were essential for down-regulation of Fas and the EGFR in vivo. Receptor expression was restored when either the dileucine pair (LL87,88) of 10.4K or 14.5K Y74 or Y122 were replaced by alanine. Whereas loss of function of the 14.5K mutant Y74 can be explained by its inability to interact with 10.4K, several lines of evidence suggest that the 10.4K dileucine pair and 14.5 Y122XXF motif function as transport signals: (i) Surface plasmon resonance spectroscopy showed that mutation of the two motifs prevents binding of 10.4K and 14.5K cytoplasmic tail peptides to purified adaptor protein complexes AP-1 and AP-2 in vitro. (ii) FACS analysis demonstrated that mutation of these motifs strongly affects FLAG-14.5K cell surface expression. (iii) In line with the FACS data, immunofluorescence microscopy revealed that mutant 14.5Y122A accumulates together with 10.4K at the cell surface, suggesting that the Y122FNL motif normally directs internalization of 10.4-14.5K. (iv) Substitution of the 10.4K dileucine pair increased the transport of 10.4-14.5K into lysosomes, resulting in enhanced degradation of both 10.4K and 14.5K without significantly disrupting complex formation. (v) The accumulation of mutant 10.4-14.5K at the cell surface upon coexpression of 10.4LL/AA and 14.5Y122A suggests that the dileucine motif acts downstream of Y122 and fulfills a sorting function subsequent to endocytosis. Transfer of the mutations into Ad2 and infection of primary fibroblasts revealed a similar defect in trafficking of 10.4LL/AA and 14.5 Y122A mutant proteins. Moreover, in infected cells substitution of the 10.4K dileucine pair and 14.5K Y122 impaired down-regulation of Fas, EGFR and both TRAIL-R1 and TRAIL-R2, implying a general role of these sorting signals for the mechanism of receptor down-regulation. Thus, two distinct transport signals present in the different subunits of the 10.4-14.5K complex seem to act in concert to establish efficient down-regulation of receptor targets. Alanine replacement mutagenesis of several other strictly conserved amino acids in 14.5K and FACS analysis of stable E3-transfectants revealed that those mutants which exhibited an altered FLAG-14.5K surface expression had defects in Fas and EGFR down-modulation. Surprisingly, Ad4 was unable to modulate Fas and EGFR expression, even though the Ad4 14.5K protein contained all the strictly conserved amino acids. As a first step to identify structural features that determine target specificity of 10.4-14.5K, I chose to replace the 10.4-14.5K ORFs in Ad2 by their Ad4 homologues. Although the Ad4 10.4-14.5K proteins could be detected in Ad4-infected cells, their expression level was drastically reduced when encoded by the Ad2 E3 region. This indicated that expression of Ad4 10.4-14.5K is differently regulated as compared to Ad2, possibly due to altered splicing. Further exploration of this system will require a detailed analysis of splicing within the Ad4 E3 region