Podcast appearances and mentions of ev d68

This episode discusses five MMWR reports. First, a new CDC study shows that updated COVID-19 vaccines protect against symptomatic illness, including infections caused by the JN.1 variant. Second, Neptune's Fix, a flavored tianeptine elixir sold in gas stations, convenience stores, and online, is associated with serious clinical outcomes in 17 patients in New Jersey. Third, acute flaccid myelitis, or AFM, remained low in the U.S. between 2019 and 2022 despite increased circulation of EV-D68, an enterovirus previously connected to an increase in AFM cases. Fourth, Peru reported its largest dengue outbreak in 2023.

Protecting Kids from Enterovirus 68 (EV-D68) - Dr. John Young, a longtime emergency room physician now specializing in the treatment of chronic and genetic diseases, notes that the children becoming infected have underlying lung or neurological diseases. "They have immune systems that are compromised," he says. "Parents can protect themselves and their kids by maximizing their immune system, and the easiest way to do that is with vitamin D."

Protecting Kids from Enterovirus 68 (EV-D68) - Dr. John Young, a longtime emergency room physician now specializing in the treatment of chronic and genetic diseases, notes that the children becoming infected have underlying lung or neurological diseases. "They have immune systems that are compromised," he says. "Parents can protect themselves and their kids by maximizing their immune system, and the easiest way to do that is with vitamin D."For Your Listening Pleasure for these Lockdown / Stay-At-Home COVID and Variants Times - For all the radio shows available on The 'X' Zone Broadcast Network visit - https://www.spreaker.com/user/xzoneradiotv.Our radio shows archives and programming include: A Different Perspective with Kevin Randle; Alien Cosmic Expo Lecture Series; Alien Worlds Radio Show; America's Soul Doctor with Ken Unger; Back in Control Radio Show with Dr. David Hanscom, MD; Connecting with Coincidence with Dr. Bernard Beitman, MD; Dick Tracy; Dimension X; Exploring Tomorrow Radio Show; Flash Gordon; Imagine More Success Radio Show with Syndee Hendricks and Thomas Hydes; Jet Jungle Radio Show; Journey Into Space; Know the Name with Sharon Lynn Wyeth; Lux Radio Theatre - Classic Old Time Radio; Mission Evolution with Gwilda Wiyaka; Paranormal StakeOut with Larry Lawson; Ray Bradbury - Tales Of The Bizarre; Sci Fi Radio Show; Seek Reality with Roberta Grimes; Space Patrol; Stairway to Heaven with Gwilda Wiyaka; The 'X' Zone Radio Show with Rob McConnell; Two Good To Be True with Justina Marsh and Peter Marsh; and many other!That's The ‘X' Zone Broadcast Network Shows and Archives - https://www.spreaker.com/user/xzoneradiotv

In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination,  resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Detection of poliovirus in immunosuppressed child (CDC) Severe respiratory illnesses associated with rhinoviruses and/or enteroviruses (CDC) Effects of vaccination and previous Omicron infection in children (NEJM) COVID-19 hospitalizations among vaccinated and unvaccinated adults (JAMA) Effectiveness of vaccines prior to Omicron (IDSA) Nasal iga wanes 9 months after COVID hospitalization (medRxiv) Resistance of Omicron subvariant to antibody neutralization (BioRxiv) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury)  Bebtelovimab fact sheet for providers (FDA) SARS-CoV-2 spike is associated with post-acute sequelae (IDSA) Impact of vaccination on the risk of developing long-COVID (The Lancet) Contribute to Floating Doctors fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 936 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

This week we will discuss Polio and Enterovirus (EV)-D68 ​Most people who get infected with poliovirus will not have any visible symptoms. About 1 out of 4 people (or 25 out of 100) with poliovirus infection will have flu-like symptoms that can include: Sore throat Fever Tiredness Nausea Headache Stomach pain ​These symptoms usually last 2 to 5 days, then go away on their own. A smaller proportion of people with poliovirus infection will develop other, more serious symptoms that affect the brain and spinal cord: Meningitis (infection of the covering of the spinal cord and/or brain)occurs in about 1–5 out of 100 people with poliovirus infection, depending on virus type Paralysis (can't move parts of the body) or weakness in the arms, legs, or both occurs in about 1 out of 200 people to 1 in 2000 people, depending on virus type ​Paralysis is the most severe symptom associated with poliovirus because it can lead to permanent disability and death. Between 2 and 10 out of 100 people who have paralysis from poliovirus infection die, because the virus affects the muscles that help them breathe. ​Even children who seem to fully recover can develop new muscle pain, weakness, or paralysis as adults, 15 to 40 years later. This is called post-polio syndrome. Note that “poliomyelitis” (or “polio” for short) is defined as the paralytic disease. So only people with the paralytic infection are considered to have the disease. (Credits: CDC) ​Enterovirus was first identified in California in 1962, enterovirus D68 (EV-D68) is one of more than 100 non-polio enteroviruses. EV-D68 can cause mild to severe respiratory illness, or no symptoms at all. Mild symptoms may include runny nose, sneezing, cough, body aches, and muscle aches. Severe symptoms may include wheezing and difficulty breathing. The link between Enterovirus D68 and a polio-like illness has been bolstered by new research showing a spike in both the virus and reports of acute flaccid myelitis in children in 2018, a new government report suggests. The report by the Centers for Disease Control and Prevention reinforces previous research that the virus strikes every other year and in the late summer and early fall. ​Anyone with respiratory illness should contact their doctor if they are having difficulty breathing or if their symptoms are getting worse. Seek immediate medical attention if you or your child develops any of these symptoms following a respiratory illness: arm or leg weakness pain in the neck, back, arms, or legs difficulty swallowing or slurred speech difficulty moving the eyes or drooping eyelids facial droop or weakness  

Protecting Kids from Enterovirus 68 (EV-D68) - Dr. John Young, a longtime emergency room physician now specializing in the treatment of chronic and genetic diseases, notes that the children becoming infected have underlying lung or neurological diseases. "They have immune systems that are compromised," he says. "Parents can protect themselves and their kids by maximizing their immune system, and the easiest way to do that is with vitamin D."For Your Listening Pleasure for these Lockdown / Stay-At-Home COVID and Variants Times - For all the radio shows available on The 'X' Zone Broadcast Network visit - https://www.spreaker.com/user/xzoneradiotv.Our radio shows archives and programming include: A Different Perspective with Kevin Randle; Alien Cosmic Expo Lecture Series; Alien Worlds Radio Show; America's Soul Doctor with Ken Unger; Back in Control Radio Show with Dr. David Hanscom, MD; Connecting with Coincidence with Dr. Bernard Beitman, MD; Dick Tracy; Dimension X; Exploring Tomorrow Radio Show; Flash Gordon; Imagine More Success Radio Show with Syndee Hendricks and Thomas Hydes; Jet Jungle Radio Show; Journey Into Space; Know the Name with Sharon Lynn Wyeth; Lux Radio Theatre - Classic Old Time Radio; Mission Evolution with Gwilda Wiyaka; Paranormal StakeOut with Larry Lawson; Ray Bradbury - Tales Of The Bizarre; Sci Fi Radio Show; Seek Reality with Roberta Grimes; Space Patrol; Stairway to Heaven with Gwilda Wiyaka; The 'X' Zone Radio Show with Rob McConnell; Two Good To Be True with Justina Marsh and Peter Marsh; and many other!That's The ‘X' Zone Broadcast Network Shows and Archives - https://www.spreaker.com/user/xzoneradiotv

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.15.299164v1?rss=1 Authors: Ma, C., Hu, Y., Townsend, J. A., Lagarias, P., Marty, M. T., Kolocouris, A., Wang, J. Abstract: There is an urgent need for vaccines and antiviral drugs to combat the COVID-19 pandemic. Encouraging progress has been made in developing antivirals targeting SARS-CoV-2, the etiological agent of COVID-19. Among the drug targets being investigated, the viral main protease (Mpro) is one of the most extensively studied drug targets. Mpro is a cysteine protease that hydrolyzes the viral polyprotein at more than 11 sites and it is highly conserved among coronaviruses. In addition, Mpro has a unique substrate preference for glutamine in the P1 position. Taken together, it appears that Mpro inhibitors can achieve both broad-spectrum antiviral activity and a high selectivity index. Structurally diverse compounds have been reported as Mpro inhibitors, with several of which also showed antiviral activity in cell culture. In this study, we investigated the mechanism of action of six previously reported Mpro inhibitors, ebselen, disulfiram, tideglusib, carmofur, shikonin, and PX-12 using a consortium of techniques including FRET-based enzymatic assay, thermal shift assay, native mass spectrometry, cellular antiviral assays, and molecular dynamics simulations. Collectively, the results showed that the inhibition of Mpro by these six compounds is non-specific and the inhibition is abolished or greatly reduced with the addition of reducing reagent DTT. In the absence of DTT, these six compounds not only inhibit Mpro, but also a panel of viral cysteine proteases including SARS-CoV-2 papain-like protease, the 2Apro and 3Cpro from enterovirus A71 (EV-A71) and EV-D68. However, none of the compounds inhibits the viral replication of EV-A71 or EV-D68, suggesting that the enzymatic inhibition potency IC50 values obtained in the absence of DTT cannot be used to faithfully predict their cellular antiviral activity. Overall, we provide compelling evidence suggesting that ebselen, disulfiram, tideglusib, carmofur, shikonin, and PX-12 are non-specific SARS-CoV-2 Mpro inhibitors, and urge the scientific community to be stringent with hit validation. Copy rights belong to original authors. Visit the link for more info

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism is not new (mBio) Letters read on TWiV 572 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore Listener Picks Anonymous - Spill the Beans vaccinated shirts Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism is not new (mBio) Letters read on TWiV 572 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore Listener Picks Anonymous - Spill the Beans vaccinated shirts Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Acute flaccid myelitis (AFM) is a rare but serious condition; one that strikes fear into the hearts of parents and providers alike. AFM affects the nervous system, specifically the gray matter of the spinal cord, which results in the presenting symptoms of a flaccid paralysis. This condition is not new. Acute flaccid myelitis appears to be caused most often by viruses, especially EV-D68, which is a member of the polio family. Although poliomyelitis has been mostly eradicated worldwide, in recent years large outbreaks of the related enterovirus 71 has been seen in Asia-Pacific countries. This virus, that some have coined “the new polio” mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders. In today’s episode we are joined by Kevin Messacar, MD to talk through the most common presentations and treatment of enterovirus infections. Dr. Messacar is both an Infectious Disease Specialist and Hospitalist at Children’s Hospital Colorado and is an Assistant Professor of Pediatrics at the University of Colorado School of Medicine. Dr. Messacar's interview in this episode is expressly his own and not on a behalf of the professional organizations he serves.  CDC AFM Guidelines and Resources for Providers What did you think of today's episode? Tweet Dr. Brent, @AlisonBrentMD or write to us chartingpediatrics@childrenscolorado.org.

Since 2014, some media and radio personalities have attributed the increase in Enterovirus D68 (EV-D68) cases in the US to immigrant children from Central America. The latest was a segment last week on the Savage Nation with Michael Savage, a very popular talk radio program. What is EV-D68 and is it an imported disease from immigrant children? I look at this in this latest installment in the Infectious Disease News Brief.

Since 2014, some media and radio personalities have attributed the increase in Enterovirus D68 (EV-D68) cases in the US to immigrant children from Central America. The latest was a segment last week on the Savage Nation with Michael Savage, a very popular talk radio program. What is EV-D68 and is it an imported disease from […] The post Enterovirus D68: ‘No evidence it’s an imported disease’ appeared first on Outbreak News Today.

The sheer reduction of poliomyelitis-ridden individuals is a testament to how effective the poliovirus vaccines are. Still, related viruses like rhinoviruses, coxsackieviruses, and enteroviruses cause significant burden to public health. What are picornaviruses? Why is there a need for researching viruses like EV-D68 and EV-A71? Let’s learn to be scientifically conversational. For all references and supplemental information, you can navigate to ascienceshow.com.  

In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482 Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522 Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraineand Europe Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504 Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479 Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484 Letters read on TWiV 528 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Pandemic Trail game Rich- On a Bat’s Wing and a Prayer Dickson- Decoding Watson Kathy- Phenotypic variation in outbred and inbred mice Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers Listener Pick Anne- Peter Hotez interview Islam- Letter from Crick to Watson (pdf) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482 Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522 Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraineand Europe Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504 Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479 Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484 Letters read on TWiV 528 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Pandemic Trail game Rich- On a Bat’s Wing and a Prayer Dickson- Decoding Watson Kathy- Phenotypic variation in outbred and inbred mice Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers Listener Pick Anne- Peter Hotez interview Islam- Letter from Crick to Watson (pdf) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit, TWiV 501) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom Listener Pick Neal- The Yoda of Silicon Valley Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit, TWiV 501) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom Listener Pick Neal- The Yoda of Silicon Valley Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Aaron Klug, 1926-2018 (Nature) Prions in sCJD eyes (mBio) Evolution of RNA viruses (mBio) Walter Gilbert's The RNA World (Nature) Image credit Letters read on TWiV 526 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Population mountains to visualize cities Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo Kathy- NASA Space Mission posters Vincent - Package Thief vs Glitter Bomb Trap Listener Pick Neal- Was a Scientist Jailed? Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Aaron Klug, 1926-2018 (Nature) Prions in sCJD eyes (mBio) Evolution of RNA viruses (mBio) Walter Gilbert's The RNA World (Nature) Image credit Letters read on TWiV 526 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Population mountains to visualize cities Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo Kathy- NASA Space Mission posters Vincent - Package Thief vs Glitter Bomb Trap Listener Pick Neal- Was a Scientist Jailed? Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Genome-edited babies (Nature) Second CRISPR pregnancy? (MIT Tech Rev) Naturally occurring DNA virus of Drosophila (PLoS Path) Upstream protein coding region in enterovirus genome We missed it in 1988! (J Virol) Letters read on TWiV 522 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - $40 internationally standard cup of tea Rich- Mars InSight Mission Dickson- New York Botanical Garden Train Show Kathy- Comedy wildlife photo awards finalists Vincent - Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research Listener Pick Fernando - Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

End Time Current Events: 10-12-14 — Part 2 Table of Contents: • Illegal Aliens bringing diseases across border!! • Mystery virus EV-D68 exploding among vaccinated children; U.S. medical system clueless without a vaccine • The five biggest lies about Ebola being pushed by government and mass media PDF: End Time Current Events 10-12-14 Click Here…

Instances of enterovirus D68 are being identified across the country and impacting children at many schools.Tune in to learn what information school nurse should be prepared to share with staff, parents and children. Follow: @schoolnurses @bamradionetwork Julia S. Sammons, MD MSCE is attending physician at the Children's Hospital of Philadelphia (CHOP), where she serves as Hospital Epidemiologist and Medical Director of the Department of Infection Prevention and Control and Assistant Professor in the Division of Infectious Diseases at the Perelman School of Medicine at the University of Pennsylvania.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Science communications fellow at ASM Can we get AIDS from mosquito bites? (J La State Med Soc) Why mosquitoes cannot transmit AIDS Isolation of Bundibugyo ebolavirus in Uganda (PLoS Path) Ebola virus disease outbreak, Nigeria (MMWR) Nigeria contains Ebola virus outbreak (NY Times) First Ebola virus case in US (NY Times) Ebola virus disease: USA ex Liberia (ProMedMail) First imported Ebola virus case in US (CDC) Assessing risk of spread of Ebola virus (PLoS Currents) How contagious is Ebola virus? (NPR) Estimating reproductive index of Ebola virus (PLoS Currents) Polio-like illness, EV-D68 suspected (ProMedMail) Polio-like illness, North America (ProMedMail) Four deaths associated with EV-D68 (NY Times) Image credit: Pigott et al eLife Letters read on TWiV 305 Video of this episode - view at YouTube Weekly Science Picks Alan - Under the knife, episode 1Kathy - UCSC Ebola genome portalVincent - Annual Review of Virology, volume 1 Listener Pick of the Week Alan - H5N1Peter - Vomiting LarryDara - I just can't wait for my vaccine! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv