Podcast appearances and mentions of thomas wang

This episode is the 3rd one that we have done recently with diaspora immigrants to the West (2nd or 3rd generation) who have gone overseas as church-planters. We've had a Nigerian Brit, a South Asian from the USA and now a Canadian of Chinese heritage. Dr. M describes 10 benefits/blessings of being Chinese and working among Muslims. He highlights some of the challenges of working and ministering in ‘shame & honour' cultures. And he describes how important it is to understand that Muslims come from very different political, cultural and theological contexts.If you would like to broaden your reading base, Dr. M recommends:1) Watchman Nee The Normal Christian Life or Sit, Walk, Stand or The Spiritual Man2) Wang Ming-Dao A Stone Made Smooth or A Call to the Church or Spiritual Food3) works by Philip Teng, John Sung or Thomas Wang... the latter of these three will have more available in English than the others.Also, to understand how to share the gospel in Honour-Shame contexts, check out The 3D Gospel by Jayson Georges and visit honorshame.comSend us a text_________________________________________________________________________________Do get in touch if you have any questions for Matt or for any of his guests.matt@frontiers.org.ukYou can find out more about us by visiting www.frontiers.org.ukOr, if you're outside the UK, visit www.frontiers.org (then select from one of our national offices). For social media in the UK:Instagram: frontiers_ukFacebook: @frontiersukfriendsAnd do check out the free and outstanding 6 week video course for churches and small groups, called MomentumYes:www.momentumyes.com (USA)www.momentumyes.org.uk (UK) _________________________________________________________________________________

30 éves Windows-funkció – ronda, de működik ITBusiness     2024-03-27 05:05:26     Mobiltech Microsoft Windows Valamit gyorsan össze le kellett kódolni, hogy tovább lehessen haladni a Windows NT fejlesztésével. Ez 30 éve történt, egy napsütötte csütörtök reggelen – és az akkor megalkotott párbeszédablak a mai napig velünk maradt. Egyszerű, de megbízható. A három évtizeddel ezelőtti munkahétkezdő napon a Microsoft redmondi központjában Dave Plummer szoftverf 3D-nyomtatással építettek iskolát a háború sújtotta Ukrajnában Igényesférfi.hu     2024-03-27 05:24:02     Infotech Ukrajna Oktatás háború A csaknem 4000 négyzetméteres oktatási intézmény Lviv városában található, és 40 óra alatt készült el egy COBOD nyomtató segítségével. Születőben a négy és fél milliószor gyorsabb internet Rakéta     2024-03-27 11:36:20     Infotech Az átlagos brit otthoni sávszélességhez képest négy és fél milliószor gyorsabb adatátviteli sebességet sikerült elérni egyetlen optikai szálon. Mindez a mostaninál radikálisan gyorsabb internetet tesz lehetővé már a mostani infrastruktúrán is. Kína részben betiltotta az Intel és AMD processzorok, valamint a Windows használatát PCW     2024-03-27 07:32:23     Infotech Kína Windows Intel AMD A korlátozás csak az állami szférát érinti, de így is nagyon fájhat az érintetteknek. Felbukkant egy fotón a Redmi Note 13 Turbo Android Portál     2024-03-27 11:19:58     Mobiltech Kína Telefon Xiaomi A Xiaomi várhatóan Snapdragon 8s Gen 3 lapkakészlettel dobja piacra Kínában a Redmi Note 13 Turbo készüléket. Eddig csak pletykákat hallottunk, többek között arról, hogy Poco F6 néven nemzetközi piacra kerülhet, de egy kiszivárgott képnek hála most már láthatjuk is a telefont. Thomas Wang, a Redmi márka vezérigazgatója arról beszélt, hogy a Xiaomi Hasznos újítást kap a mobilos YouTube app 24.hu     2024-03-27 10:28:05     Mobiltech YouTube A funkció csak bizonyos sportcsatornák esetében működik, de nem kizárt, hogy a későbbiekben kiterjesztik más típusú tartalmakra is. Megint egy félkész termék bevezetésén erőlködnek a Google-nél Bitport     2024-03-27 13:33:00     Infotech Google Böngésző Bár egyelőre igencsak megbízhatatlannak tűnnek a Google keresőjének MI-alapú áttekintései, már olyan felhasználók böngészőjében is felbukkantak, akik nem jelentkeztek a Google Search Lab SGE funkciójának tesztelésére. A Tcl megmutatja, hogyan válhat egy Tv a filmek élvezetének igazi forrásává Digital Hungary     2024-03-27 13:14:00     Infotech Mozi A TCL Electronics (1070.HK) vezető szórakoztatóelektronikai brand és a világ két legnagyobb tévégyártójának egyike bemutatja, hogy milyen jellemzői vannak egy olyan tévének, amit kifejezetten a filmrajongók számára fejlesztettek ki. A TCL elkötelezett annak érdekében, hogy a mozik világát otthonok millióiba elvigye szerte a világon, és hogy egy ide A kvantumgravitáció után kutatnak az Antarktiszon Telex     2024-03-27 08:44:29     Tudomány Antarktisz A módszertan viszont megvan, a következő lépés a légköri részecskék helyett az űrből érkező neutrínók tanulmányozása lesz. Csúcstabletet és fülhallgatót is hozott a Vivo Mobilarena     2024-03-27 10:10:00     Mobiltech Vivo A Vivo Pad3 Pro és TWS 4 Series vezetékmentes fülesek az X Fold3 hajlítható szériát kísérték. Megvan, mikor érkezhet Elon Musk népautója, a szuperolcsó Tesla NRGreport     2024-03-27 04:35:23     Gazdaság Olcsó Elon Musk Tesla Március 15. Az Autocar egy 2024. március 15-én megjelent jelentésében azt írta, hogy a Tesla "Model 2" - a Tesla régóta várt olcsóbb autója - jövőre kerül gyártásba. Van élet a Földön kívül? És akarjuk-e, hogy ránk találjon? Tudás.hu     2024-03-27 05:27:12     Életmód Világűr Emberi fajunk fennmaradását kockáztatjuk-e azzal, hogy részletes útmutatót küldünk a Világűrbe magunkról? Elképzelhető-e, hogy milliárdszor milliárd nagyságrendű lehetőség közül a Föld az egyedüli otthona egy intelligens fajnak? Boldog Ádámot, a Svábhegyi Csillagvizsgáló bemutató csillagászát kérdezte a tudás.hu. Keressük a Földön kívüli életet az Elkészült az első magyar űreszköz által készített felvétel hazánkról Hungarianpress     2024-03-27 04:47:41     Tudomány Balaton Tavasz Világűr Műhold Mount Everest A VIREO magyar műhold már számos lenyűgöző felvételt készített a Föld felszínéről, a Nílus deltájától a Mount Everest havas csúcsáig, a C3S Kft. munkatársai számára mégis a legkedvesebb felvételek a Balaton tavaszi ébredését örökítik meg. A napokban megérkeztek az első fotók, melyeket magyar műhold készített hazánk egy, az űrből is jól azonosítható A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

30 éves Windows-funkció – ronda, de működik ITBusiness     2024-03-27 05:05:26     Mobiltech Microsoft Windows Valamit gyorsan össze le kellett kódolni, hogy tovább lehessen haladni a Windows NT fejlesztésével. Ez 30 éve történt, egy napsütötte csütörtök reggelen – és az akkor megalkotott párbeszédablak a mai napig velünk maradt. Egyszerű, de megbízható. A három évtizeddel ezelőtti munkahétkezdő napon a Microsoft redmondi központjában Dave Plummer szoftverf 3D-nyomtatással építettek iskolát a háború sújtotta Ukrajnában Igényesférfi.hu     2024-03-27 05:24:02     Infotech Ukrajna Oktatás háború A csaknem 4000 négyzetméteres oktatási intézmény Lviv városában található, és 40 óra alatt készült el egy COBOD nyomtató segítségével. Születőben a négy és fél milliószor gyorsabb internet Rakéta     2024-03-27 11:36:20     Infotech Az átlagos brit otthoni sávszélességhez képest négy és fél milliószor gyorsabb adatátviteli sebességet sikerült elérni egyetlen optikai szálon. Mindez a mostaninál radikálisan gyorsabb internetet tesz lehetővé már a mostani infrastruktúrán is. Kína részben betiltotta az Intel és AMD processzorok, valamint a Windows használatát PCW     2024-03-27 07:32:23     Infotech Kína Windows Intel AMD A korlátozás csak az állami szférát érinti, de így is nagyon fájhat az érintetteknek. Felbukkant egy fotón a Redmi Note 13 Turbo Android Portál     2024-03-27 11:19:58     Mobiltech Kína Telefon Xiaomi A Xiaomi várhatóan Snapdragon 8s Gen 3 lapkakészlettel dobja piacra Kínában a Redmi Note 13 Turbo készüléket. Eddig csak pletykákat hallottunk, többek között arról, hogy Poco F6 néven nemzetközi piacra kerülhet, de egy kiszivárgott képnek hála most már láthatjuk is a telefont. Thomas Wang, a Redmi márka vezérigazgatója arról beszélt, hogy a Xiaomi Hasznos újítást kap a mobilos YouTube app 24.hu     2024-03-27 10:28:05     Mobiltech YouTube A funkció csak bizonyos sportcsatornák esetében működik, de nem kizárt, hogy a későbbiekben kiterjesztik más típusú tartalmakra is. Megint egy félkész termék bevezetésén erőlködnek a Google-nél Bitport     2024-03-27 13:33:00     Infotech Google Böngésző Bár egyelőre igencsak megbízhatatlannak tűnnek a Google keresőjének MI-alapú áttekintései, már olyan felhasználók böngészőjében is felbukkantak, akik nem jelentkeztek a Google Search Lab SGE funkciójának tesztelésére. A Tcl megmutatja, hogyan válhat egy Tv a filmek élvezetének igazi forrásává Digital Hungary     2024-03-27 13:14:00     Infotech Mozi A TCL Electronics (1070.HK) vezető szórakoztatóelektronikai brand és a világ két legnagyobb tévégyártójának egyike bemutatja, hogy milyen jellemzői vannak egy olyan tévének, amit kifejezetten a filmrajongók számára fejlesztettek ki. A TCL elkötelezett annak érdekében, hogy a mozik világát otthonok millióiba elvigye szerte a világon, és hogy egy ide A kvantumgravitáció után kutatnak az Antarktiszon Telex     2024-03-27 08:44:29     Tudomány Antarktisz A módszertan viszont megvan, a következő lépés a légköri részecskék helyett az űrből érkező neutrínók tanulmányozása lesz. Csúcstabletet és fülhallgatót is hozott a Vivo Mobilarena     2024-03-27 10:10:00     Mobiltech Vivo A Vivo Pad3 Pro és TWS 4 Series vezetékmentes fülesek az X Fold3 hajlítható szériát kísérték. Megvan, mikor érkezhet Elon Musk népautója, a szuperolcsó Tesla NRGreport     2024-03-27 04:35:23     Gazdaság Olcsó Elon Musk Tesla Március 15. Az Autocar egy 2024. március 15-én megjelent jelentésében azt írta, hogy a Tesla "Model 2" - a Tesla régóta várt olcsóbb autója - jövőre kerül gyártásba. Van élet a Földön kívül? És akarjuk-e, hogy ránk találjon? Tudás.hu     2024-03-27 05:27:12     Életmód Világűr Emberi fajunk fennmaradását kockáztatjuk-e azzal, hogy részletes útmutatót küldünk a Világűrbe magunkról? Elképzelhető-e, hogy milliárdszor milliárd nagyságrendű lehetőség közül a Föld az egyedüli otthona egy intelligens fajnak? Boldog Ádámot, a Svábhegyi Csillagvizsgáló bemutató csillagászát kérdezte a tudás.hu. Keressük a Földön kívüli életet az Elkészült az első magyar űreszköz által készített felvétel hazánkról Hungarianpress     2024-03-27 04:47:41     Tudomány Balaton Tavasz Világűr Műhold Mount Everest A VIREO magyar műhold már számos lenyűgöző felvételt készített a Föld felszínéről, a Nílus deltájától a Mount Everest havas csúcsáig, a C3S Kft. munkatársai számára mégis a legkedvesebb felvételek a Balaton tavaszi ébredését örökítik meg. A napokban megérkeztek az első fotók, melyeket magyar műhold készített hazánk egy, az űrből is jól azonosítható A további adásainkat keresd a podcast.hirstart.hu oldalunkon.

We introduce Mixtral 8x7B, a Sparse Mixture of Experts (SMoE) language model. Mixtral has the same architecture as Mistral 7B, with the difference that each layer is composed of 8 feedforward blocks (i.e. experts). For every token, at each layer, a router network selects two experts to process the current state and combine their outputs. Even though each token only sees two experts, the selected experts can be different at each timestep. As a result, each token has access to 47B parameters, but only uses 13B active parameters during inference. Mixtral was trained with a context size of 32k tokens and it outperforms or matches Llama 2 70B and GPT-3.5 across all evaluated benchmarks. In particular, Mixtral vastly outperforms Llama 2 70B on mathematics, code generation, and multilingual benchmarks. We also provide a model fine-tuned to follow instructions, Mixtral 8x7B - Instruct, that surpasses GPT-3.5 Turbo, Claude-2.1, Gemini Pro, and Llama 2 70B - chat model on human benchmarks. Both the base and instruct models are released under the Apache 2.0 license. 2024: Albert Q. Jiang, Alexandre Sablayrolles, Antoine Roux, Arthur Mensch, Blanche Savary, Chris Bamford, Devendra Singh Chaplot, Diego de Las Casas, Emma Bou Hanna, Florian Bressand, Gianna Lengyel, Guillaume Bour, Guillaume Lample, L'elio Renard Lavaud, Lucile Saulnier, Marie-Anne Lachaux, Pierre Stock, Sandeep Subramanian, Sophia Yang, Szymon Antoniak, Teven Le Scao, Théophile Gervet, Thibaut Lavril, Thomas Wang, Timothée Lacroix, William El Sayed https://arxiv.org/pdf/2401.04088.pdf

 CTL Script/ Top Stories of December 9th        Publish Date: December 8th    Henssler :15  From the Ingles Studio Welcome to the Award-Winning Cherokee Tribune Ledger Podcast  Today is Saturday, December 9th and Happy 69th Birthday to actor JOHN MALKOVICH. ***12.09.23 - BIRTHDAY - JOHN MALKOVICH*** I'm Keith Ippolito and here are the stories Cherokee is talking about, presented by Credit Union of Georgia.  Waleska Man Convicted of Assaulting Girlfriend Canton Man Sentenced to 20 Years of Prison for Child Sexual Abuse Two CCSD Students Win State Academic Quiz Bowl We'll have all this and more coming up on the Cherokee Tribune-Ledger Podcast, and if you're looking for Community news, we encourage you to listen and subscribe!  Commercial: CU of GA STORY 1: Waleska Man Convicted of Assaulting Girlfriend Bradley Scott McDaniel, a Waleska man, has been convicted on charges including family violence aggravated assault, false imprisonment, family violence battery, cruelty to children, and simple battery. The Cherokee County District Attorney's Office announced the jury's verdict after a three-day trial. The charges stem from a February assault on McDaniel's girlfriend, during which he allegedly applied pressure to her neck, leaving visible marks. The victim, who escaped to a neighbor, reported incidents of domestic abuse. McDaniel will be sentenced in January. The case was investigated by the Cherokee Sheriff's Office and prosecuted by Deputy Chief Assistant District Attorney Rachel Ashe. STORY 2: Canton Man Sentenced to 20 Years of Prison for Child Sexual Abuse Jonathan Ricky Millwood, a Canton man, has been sentenced to two decades in prison after pleading guilty to charges including two counts of aggravated sexual battery, one count of aggravated child molestation, and one count of child molestation. The Canton Police Department investigated the case, initiated in March 2023 when a girl under 10 reported inappropriate touching by Millwood. The child's disclosure led to forensic interviews, a Sexual Assault Nurse Exam confirming male DNA, and Millwood's guilty plea. He received a 20-year prison sentence without parole, life probation, and lifetime registration as a sex offender. Millwood is prohibited from contacting the victim or her family. STORY 3: Two CCSD Students Win State Academic Quiz Bowl Two students from Cherokee County School District secured first place in statewide academic quiz bowl competitions. Woodstock High School senior Owen Markette topped the social studies quiz bowl, focusing on early American history, while Creekview High School sophomore Thomas Wang secured first place in the spelling quiz bowl. These achievements were part of the Georgia Career and Technical Instruction program's Fall Leadership Conference, where students from across the state participated in various academic and leadership events. Both winners will be recognized by the Cherokee County School Board for their achievements at an upcoming meeting. We have opportunities for sponsors to get great engagement on these shows. Call 770.874.3200 for more info.  Back in a moment  Break: DRAKE – ESOG – INGLES 1 STORY 4: Sequoyah High School Teacher Honored with State Award Casandra Hembree, who leads the Work-Based Learning program at Sequoyah High School, has received the Outstanding Achievement in Career Awareness and Exploration Award from the Georgia Department of Education. The award recognizes her excellence in career education, particularly for her role in the WBL program that allows high school students to earn school credit while working in a job related to their Career Pathway studies. Hembree has been serving as the WBL program coordinator at Sequoyah High School for seven years, contributing to the success of students like Emily Brown, who earned the 2023 Georgia WBL Student of the Year Award for the northwest region. STORY 5: Georgia General Assembly Passes Republican-Drawn Congressional Map The Georgia House has given final approval to a new congressional map in response to a federal judge's ruling that the current map violates the Voting Rights Act. The new map, passed along party lines by the Republican-controlled House, creates an additional Black-majority district in the western part of metro Atlanta, complying with the judge's order. Democrats argue that the map eliminates a "coalition" congressional district and accuse Republicans of political gerrymandering to maintain their 9-5 majority in Georgia's congressional delegation. The new maps for the state House and Senate were also adopted earlier in the week. Commercial: CHEROKEE CHAMBER – HELLER LAW STORY 6: Woodstock Woman Named Finalist for Georgia's Early Childhood Educators of the Year Donna Humphries, an early childhood educator from Woodstock, has been named a finalist for the Georgia Department of Early Care and Learning's Toddler Teacher of the Year. This recognition is part of the state's Early Childhood Educators of the Year program, honoring outstanding teachers of children aged birth to preschool. Each finalist will receive $500, and winners, to be announced in December, will receive cash prizes for personal use, a classroom makeover, and funding for their school. The winners will serve as ambassadors for the program, highlighting effective classroom practices and making public speaking appearances. STORY 7: Candlelight Vigil to Remember Homeless Veterans Dec. 21 The Cherokee County Homeless Veterans Program is hosting a candlelight vigil on December 21 at Cherokee Veterans Park to remember homeless veterans. The vigil, starting at 5:15 p.m., will include a moment of silence, prayer, and wreath-laying. The event aims to raise awareness about homelessness among veterans, with the program reporting a 32% increase in homeless veterans compared to the previous year. The public is invited to attend the vigil at the homeless veterans statue at Cherokee Veterans Park. The nonprofit emphasizes the growing concern for homeless female and senior veterans, as well as those with small children. We'll have closing comments after this.  COMMERCIAL: Henssler 60  SIGN OFF –   Thanks again for listening to today's Cherokee Tribune Ledger podcast. . If you enjoy these shows, we encourage you to check out our other offerings, like the Marietta Daily Journal Podcast, the Gwinnett Daily Post, the Community Podcast for Rockdale Newton and Morgan Counties, or the Paulding County News Podcast. Get more on these stories and other great content at tribune ledger news.com. Giving you important information about our community and telling great stories are what we do.   Did you know over 50% of Americans listen to podcasts weekly? Make sure you join us for our next episode and be sure to share this podcast on social media with your friends and family. Add us to your Alexa Flash Briefing or your Google Home Briefing and be sure to like, follow, and subscribe wherever you get your podcasts.    www.henssler.com  www.inglesmarkets.com  www.esogrepair.com  www.elonsalon.com  www.jeffhellerlaw.com  www.drakerealty.com www.cherokeechamber.com www.bgpodcastnetwork.com   #NewsPodcast #CurrentEvents #TopHeadlines #BreakingNews #PodcastDiscussion #PodcastNews #InDepthAnalysis #NewsAnalysis #PodcastTrending #WorldNews #LocalNews #GlobalNews #PodcastInsights #NewsBrief #PodcastUpdate #NewsRoundup #WeeklyNews #DailyNews #PodcastInterviews #HotTopics #PodcastOpinions #InvestigativeJournalism #BehindTheHeadlines #PodcastMedia #NewsStories #PodcastReports #JournalismMatters #PodcastPerspectives #NewsCommentary #PodcastListeners #NewsPodcastCommunity #NewsSource #PodcastCuration #WorldAffairs #PodcastUpdates #AudioNews #PodcastJournalism #EmergingStories #NewsFlash #PodcastConversationsSee omnystudio.com/listener for privacy information.

We introduce Mistral 7B v0.1, a 7-billion-parameter language model engineered for superior performance and efficiency. Mistral 7B outperforms Llama 2 13B across all evaluated benchmarks, and Llama 1 34B in reasoning, mathematics, and code generation. Our model leverages grouped-query attention (GQA) for faster inference, coupled with sliding window attention (SWA) to effectively handle sequences of arbitrary length with a reduced inference cost. We also provide a model fine-tuned to follow instructions, Mistral 7B -- Instruct, that surpasses the Llama 2 13B -- Chat model both on human and automated benchmarks. Our models are released under the Apache 2.0 license. 2023: Albert Qiaochu Jiang, Alexandre Sablayrolles, Arthur Mensch, Chris Bamford, Devendra Singh Chaplot, Diego de Las Casas, Florian Bressand, Gianna Lengyel, Guillaume Lample, Lucile Saulnier, L'elio Renard Lavaud, Marie-Anne Lachaux, Pierre Stock, Teven Le Scao, Thibaut Lavril, Thomas Wang, Timothée Lacroix, William El Sayed https://arxiv.org/pdf/2310.06825.pdf

Expertentalk. Wie verändert die digitale Transformation die Finanz- und Versicherungslandschaft? In welchen Bereichen investieren Unternehmen und was dürfen sich Kunden erwarten? Antworten lieferten im Rahmen der Initiative #nextlevel Helmut Fallmann, Mitgründer und Vorstandsmitglied der Fabasoft AG, Erich Lehner, Managing Partner Markets bei EY Österreich, Paul Lubusch, Geschäftsführer von IT Finance Consulting, Sonja Steßl, Vorstandsdirektorin der Wiener Städtischen Versicherung, und Thomas Wang, Mitglied der Geschäftsleitung der Funk Gruppe. Kooperationshinweis: Die Initiative #nextlevel basiert auf einer Medienkooperation mit der „Presse“ und wird finanziell von Fabasoft AG unterstützt. ** Werbung **

Apple held its annual WWDC event this week, where it announced a whole bunch of new software features for its mobile and desktop platforms. It was also yet another opportunity for Apple to insist that all you need to do to simplify your life is buy more Apple products. This week on Gadget Lab, WIRED senior associate reviews editor Adrienne So and WIRED reviews editor Julian Chokkattu join us to talk about WWDC and the pros and cons of assimilating into Apple's ecosystem. Show Notes:  Read Lauren's story about Apple's walled garden of products. Read Julian's story about the biggest features coming to your iPhone this fall. Check out everything Apple announced at WWDC here. Recommendations:  Adrienne recommends Anve Swimwear for this post-pandemic hot mess summer. Julian recommends the Secretlab Magnus Desk. Lauren recommends Tom Simonite's WIRED profile of ousted Google researcher Timnit Gebru. Mike recommends the browser extension Minimal Twitter built by Thomas Wang. Adrienne So can be found on Twitter @adriennemso. Julian Chokkattu is @JulianChokkattu. Lauren Goode is @LaurenGoode. Michael Calore is @snackfight. Bling the main hotline at @GadgetLab. The show is produced by Boone Ashworth (@booneashworth). Our theme music is by Solar Keys. If you have feedback about the show, or just want to enter to win a $50 gift card, take our brief listener survey here. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Thomas Wang joins Beau and Dan to discuss myriad topics. Wang talks about his Jiu Jitsu journey and reflects on what he needs to work on as a practitioner and as a person. Additionally, we discuss a breadth of topics outside Jiu Jitsu including: the importance of family, structure, trying new things, being honest with yourself and diet.

This week’s episode includes author Mark Chan, editorialist Thomas Wang, and Associate Editor Wendy Post as they discuss the prioritization of candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. TRANSCRIPT BELOW: Dr Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr Greg Hundley: And I'm Greg Hundley, associate editor, director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Well, Carolyn, this week's feature, really interesting, involving proteomics and single-cell transcriptomics, trying to identify how we could prioritize individuals after they've sustained myocardial infarction as to whether or not they'll develop heart failure. Lots to go over in that feature. But before we get to that, how about we grab a cup of coffee and start in with some of the other interesting papers in this issue? Dr Carolyn Lam: Absolutely. I've got my coffee and I have to tell you though, I am so excited about this feature, it comes from Singapore, but my first paper too is about transcriptomic profiling. But Greg, I have to ask you first, have you heard of the cardiac cellulome? Dr Greg Hundley: Oh my goodness, Carolyn. So you're starting the reverse-quiz strategy to help me. I have not heard of the cellulome. Help enlighten me. Dr Carolyn Lam: I just love that word. We've heard of all kinds of other omes, but this cellulome is something I've learned through today's paper. So the authors today who are Alexander Pinto from Baker Heart and Diabetes Institute and colleagues, they developed a novel cardiac single-cell transcriptomic strategy to characterize the cardiac cellulome. And that refers to the network of cells that forms the heart. The method was utilized to profile the cardiac cellular ecosystem in response to two weeks of angiotensin II as a pro-fibrotic stimulus. So what did they find? Well, they identified two previously undescribed cardiac fibroblasts populations that are the key drivers of fibrosis. Their names were Fibroblast-Cilp and Fibroblast-THBS4. Now, these do not correspond to smooth muscle actin-expressing myofibroblasts, which have been widely viewed as the primary drivers of fibrosis. So this is really novel. The cardiac cellular landscape was sexually dimorphic at the cell abundance and gene expression level, including cellular responses to angiotensin II induced tissue remodeling. So these data really provide insights into the cellular and molecular mechanisms that promote pathologic remodeling in the mammalian heart, and really highlight that early transcriptional changes precede chronic cardiac fibrosis. Dr Greg Hundley: Very nice, Carolyn. Well, let me switch to the clinical realm. And my first paper comes from Professor Holger Thiele from the Heart Center Leipzig at the University of Leipzig, and it's involving general versus local anesthesia with conscious sedation for patients undergoing TAVI procedures. So the study comes from the SOLVE-TAVI study, and it's a multi-center open-label 2x2 factorial randomized trial of 447 patients with aortic stenosis undergoing transfemoral TAVR, comparing conscious sedation versus general anesthesia. And the primary efficacy endpoint was powered for equivalence, and consisted of the composite of all-cause mortality, stroke, myocardial infarction, infection requiring antibiotic treatments, and acute kidney injury at 30 days. Dr Carolyn Lam: Wow, Greg, as I understand it, about half of patients today receive TAVI or TAVR with conscious sedation. So it's really an important question. So what did they find? Dr Greg Hundley: You're exactly right. So the composite end point occurred in 27% of the conscious sedation patients and 26% of the general anesthesia patients. Really equivalent. And this held true for each of those composite endpoints. In addition, there was a lower need for inotropes or vasopressors with conscious sedation, versus general anesthesia. Thus, these findings suggest that conscious sedation can safely be used for patients undergoing TAVR procedures. Dr Carolyn Lam: Very important clinical one, Greg. Well, I've got a clinical paper for you too. And this one, trying to answer the question, what's the optimal duration of dual anti-platelet therapy, or DAPT, after PCI with drug-eluting stents. A very familiar, perhaps, an important question. So these authors, led by Dr Deepak Bhatt from Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, performed a systematic review and network meta-analysis of 24 randomized controlled trials comparing short-term DAPT, or less than six months, followed by aspirin or P2Y12 inhibitor monotherapy, versus mid-term DAPT, which was six months, versus 12 months DAPT, as well as an extended-term DAPT, which was more than a year after PCI with a drug-eluting stent. Dr Greg Hundley: So Dr Carolyn, three groups, what did they find? Dr Carolyn Lam: Compared to 12 months DAPT, short-term DAPT followed by P2Y12 inhibitor monotherapy reduced major bleeding after PCI with a drug-eluting stent, whereas extended-term DAPT reduce myocardial infarction at the expense of more bleeding events. Overall, the extended-term DAPT was associated with a higher risk of major bleeding compared with all other DAPT groups, except in patients with acute coronary syndrome. Dr Greg Hundley: So extended, more bleeding complications. So take me home on this, Carolyn, what is the final message here? Dr Carolyn Lam: Here's the message. Compared with 12-month DAPT, the net clinical benefit appears to favor short-term DAPT followed by P2Y12 inhibitor monotherapy instead of aspirin in select patients. Although, extended term DAPT has a role for patients who have a low bleeding risk, but a higher ischemic risk, such as those with acute coronary syndrome, thus a personalized approach appears to be warranted. Dr Greg Hundley: Very good. Well, I'm going to turn back to the world of basic science and discuss a paper related to pulmonary hypertension. And it comes from Dr Sébastien Bonnet from the University Laval. So Carolyn, the subcellular mechanisms that govern the transition from a compensated to a de-compensated right ventricle in patients with pulmonary hypertension remain poorly understood, and as a consequence, there are no clinically established treatments for RV failure and a paucity of clinically useful biomarkers. So this study investigated the long non-encoding RNAs, powerful regulators of cardiac development disease, in relation to adverse RV remodeling in pulmonary artery hypertension. Dr Carolyn Lam: So these LNK RNAs, I think that's what they're called, right? Long non-coding RNAs, what did they find? Dr Greg Hundley: This was another one of our really nice translational articles, because they combined results from both animals and human subjects. The authors demonstrated that the long non-coding RNA H19 is upregulated in decompensated right ventricles due to pulmonary hypertension, and the finding correlated with RV hypertrophy and fibrosis. Now, similar findings were observed in monocrotaline and pulmonary artery banded rats. The authors found that silencing H19 limits pathological RV hypertrophy, fibrosis, and capillary rarefaction, thus preserving RV function in those two models of pulmonary hypertension, both the monocrotaline and the pulmonary artery banded rats, without effecting pulmonary vascular remodeling. And finally, Carolyn, the authors found that circulating H19 levels in plasma of patients, discriminate pulmonary arterial hypertension patients from controls correlated with RV function and predicted long-term survival in two independent idiopathic pulmonary artery hypertension cohorts. Moreover, H19 levels delineated subgroups of patients with differential prognosis, when combined with NT-proBNP levels or the risk score proposed by both the Reveal and the 2015 European Pulmonary Hypertension Guidelines. So, in summary, these authors findings identify H19 as a potentially new therapeutic target to impede the development of maladaptive RV remodeling, and thus a promising biomarker as well of pulmonary arterial hypertension severity and prognosis. Dr Carolyn Lam: Oh, Greg, I love that. Not just the paper, but the way you explained it. Thanks so much. Well, let's dip into what else there is in today's issue, shall we? First, there's Global Rounds by Dr Yacoub entitled, Towards Meeting the Challenges of Improving Cardiovascular Health in Egypt. There's a research letter by Dr Cheng on imaging the sarcoplasmic reticulum calcium signaling in intact cardiac myocytes. There's another Research Letter by Dr Angiolillo on the pharmacodynamic and pharmacokinetic effects of a low maintenance dose ticagrelor regimen, versus standard dose clopidogrel, in patients with diabetes without prior major cardiovascular events, undergoing elective PCI. And this is the OPTIMUS-6 study. There's an On my Mind paper by Dr Santos on coronary artery calcification and familial hypercholesterolemia, and an ECG Challenge by Dr Liu, which is not your uncommon electrocardiographic findings, and really looking at Q waves with post-QRS deflections. I'll let you take a look. Dr Greg Hundley: Oh, wow, Carolyn. This issue is just jammed with really nice articles. I've got a research letter entitled, Long-Term Outcomes After Infective Endocarditis, Following Transcatheter Aortic Valve Replacement, and it's from Dr Josep Rodés-Cabau from Quebec Heart and Lung Institute. And then finally, a nice exchange of letters by Drs Rozenbaum, Kemner, and Parasuraman regarding the article Cost-Effectiveness of Tafamidis Therapy for Transthyretin Amyloid Cardiomyopathy, and there's a very nice response by Dr Kazi. Now we get to proceed on to that feature article. Dr Carolyn Lam: Yay! Let's go, Greg. Dr Greg Hundley: Well listeners, we are to our feature discussion. And today we have Dr Mark Chan from the National University of Singapore, our own associate editor, Dr Wendy Post from Johns Hopkins, and Dr Thomas Wang from the University of Texas Southwestern Medical Center. Well, Mark, we'll start with you. Could you explain to us some of your thinking behind how you formulated this study and what was the hypothesis that you wanted to address? Dr Mark Chan: The background, really, was to try to prioritize protein candidates in post myocardial infarction heart failure. We do know that there are several hundred candidates out there in the literature, but really, what we wanted to do was to try to enrich and select out what we thought would be the most biologically relevant proteins. And really, the hypothesis was that, by combining two very powerful unbiased discovery tools that have been developed in the last few years, we would be able to achieve this goal. The two tools, I think, Tommy would be very familiar with, because he's used plasma proteomics as well in a lot of his work. That's one of the unbiased discovery tools that we used. Measuring 1300 proteins in blast mine. Second two was a single-cell transcriptomics where we're able to look at RNA sequences, genome RNA sequences, at the individual cell level. So we first started off with cohorts of patients with acute myocardial infarction that were followed up for about five years for heart failure events, and we obtained plasma from these patients at about 30 days after myocardial infarction. So with the initial plasma proteomics, and found more than 200 candidates, actually very similar to what we actually see in the literature in terms of protein candidates predicting heart failure, in particular, post-MI heart failure. We then thought that what we really want to do is prioritize the most important proteins, and that's when we went onto single-cell transcriptomics. And we found a total of 83 protein candidates, which were directionally similar across the human plasma proteomics and the single-cell transcriptomic data across different models of ischemic heart failure. And six candidates are the ones that we are hoping to discuss a bit more about, the top six candidates, today, which I'm sure you'll ask me about very soon. Dr Greg Hundley: You've really led us into the next question. Tell us a little bit about the six candidates. Dr Mark Chan: The top six candidates to all of us are really familiar with NT-proB natriuretic peptide that's been around for decades, cardiac troponin, that's the second well-known, well-established candidate, and four other candidates that seem to be really emerging as potential targets in heart failure and ischemic cardiomyopathy. Angiopoietin-2, thrombospondin-2, latent-transforming growth factor binding protein 4, and a less commonly investigated protein, FSLT3, or follistatin-like related protein 2. The two candidates that are particularly interesting to me are angiopoietin-2 and thrombospondin-2 , and looking at a lot of Tommy Wang's work as well, we can see that these two candidates looking to be important future targets for biomarker discovery, validation, and maybe, potentially, druggable candidates to manage patients with post-MI heart failure and ischemic cardiomyopathy. Dr Greg Hundley: Wendy, coming to you as an associate editor and really an expert in genetic epidemiology, what intrigued you about this article? Especially I heard Mark discuss differentially expressed genetics and transcriptomics. What brought you to this article and what increased its relevance to you? Dr Wendy Post: We were very intrigued by both the importance of the problem that was being addressed, in that ischemic cardiomyopathy is a very common and major challenge that we all encounter as cardiologists, but also the unique approach that was used to handle a large amount of data. So with the plasma proteomic approach, which Mark described as the first step, you take thousands of data points and try to narrow it down, which he did, but still needed to narrow it down even more. And then use a complimentary, but different, approach to try to understand which of these hits, so to speak, maybe the ones that are important. And so using the single-cell transcriptomic approach, was able to narrow down to these six candidates. And then it was very reassuring that two of the six were what we would have hypothesized. So if you didn't find those, we'd worry that maybe something was wrong with your approach. So on the one hand, you'd say, "Well, we already knew that. So what are you telling us?" But it actually was proof, so to speak, that your approach was working, and that these other four novel candidates might turn out to be the next BNP. So that was really a few of the things that intrigued us about this paper. Dr Greg Hundley: So Tommy, as a practicing clinical cardiologist, and then also, really, as a clinician researcher, what do you see as relevant with Mark's work and also Wendy's description here for all of us that are seeing patients that has sustained myocardial infarction? Dr Thomas Wang: I think as Mark and Wendy have both nicely summarized, but I'll revisit, they're really two areas in which knowledge of these biomarkers could impact patient care down the road. One is an informative set of biomarkers to tell us which among the large number of patients with myocardial infarction might be destined to develop heart failure so that we can, as clinicians, ramp up our therapies, increase our vigilance, increase our monitoring, so that we might be able to intervene on that at a very early stage, or even before the heart failures develop. The second, which is potentially even more exciting, is the possibility that some of these biomarkers might be so informative of pathways leading to heart failure, that we could actually directly intervene on the pathways that are reflected by these biomarkers. So in other words, biomarkers would tell us not just biology, but about therapeutically effective strategies. And I think, as Mark has nicely emphasized, there are scores, if not hundreds, of biomarkers that have been looked at in this context, and there's no amount of resource in the world that allows investigators to pursue, in prospective clinical studies or experimental studies, all of these biomarkers. And so the real value of their study is to illustrate an approach for winnowing down this large number of biomarkers down to a smaller set, a much smaller set, that seem really worth pursuing in further study. Dr Greg Hundley: Well, with that lead in, Tommy and Mark and Wendy, maybe start with you, Mark, what do you see as the next step and this area of research moving forward? Dr Mark Chan: I think I need to sound a word of caution first with respect to the study itself. It is, at the end of the day, still a very descriptive study. Heavy in bioinformatic elucidation of targets. So careful mechanistic validation and further understanding of these highly prioritized targets will still be important. In terms of how we can potentially get these results closer to the post-MI heart failure patients, closer to the bedside, one concept that I think it's becoming increasingly apparent is that a lot of these bioactive proteins in circulating plasma are likely a part of the secretome. Part of what we call exosomes or micro-bubbles that are secreted by cells. And we do see the origin big cells in the single-cell studies as part of this paper. We do get an idea. A lot of these cells really are within the extracellular matrix, which is the substrate in which your cardiomyocytes are embedded. We think that enriching the plasma for the exosome fraction, which one of my colleagues is now working on, could be the best way to derive a more powerful tool for prognostication. To really determine with a high level of specificity, not just sensitivity, but highly specific to determine which patients end up with post-myocardial infarction heart failure. So enriching plasma for exosomes and potentially looking at the proteins within these exosomes, we've already started work on that. And so far, the results, compared to the proteins just measured in free plasma, seem to predict heart failure events a lot better when we come down to the exosome fraction. The other project, this is using exosomes to treat post-MI large animal models. So we have injected mesenchymal cell stem cell derived exosomes, and we've shown that they can reduce infarct size in large animal models, and also prevent some of the hemodynamic complications that result in heart failure. But really, trying to find which are the proteins actually are meaningfully preventing heart failure and reducing infarct size, I think that is also going to be part of the next steps. Dr Greg Hundley: Mark, thank you for that summary. Tommy, do you have anything to add to that? Dr Thomas Wang: I certainly agree with all that's been said. I would also emphasize that understanding the biology of some of these newer biomarkers and how they might link heart failure or active MI is going to be really important when we consider potential clinical applications. And so, further along the experimental line, I think animal models, mouse models, and other types of models, being which the biology and pathways we would manipulate it so that we can see whether these biomarkers truly do reflect etiologic pathways in heart failure would be valuable. Dr Greg Hundley: Thank you, Tommy. Well, listeners, we've had a great presentation from Dr Mark Chan, an excellent review by both Wendy Post and Tommy Wang, emphasizing how we are discovering new protein biomarkers using plasma proteomics for identification of those that may develop heart failure after myocardial infarction. And more to come in this area. We feel very privileged to have the opportunity to work with bright young investigators like this and present this work in Circulation For both Carolyn and myself, we wish you a great week and look forward to catching you next week on the Run. This program is copyright American Heart Association, 2020.

NEW PODCAST!... What a night!! Big thanks to Billy Floyd and El Commodore with KitchenKillaz ...We also want to thank Thomas Wang with Sus Hi Eatstation Some of the best food we have had on the show yet! ABSOLUTELY INCREDIBLE!! Live at Dropkick Radio!

Download PDF Welcome to Larisa English Club #20 What’s in The News? Micro-green Study Shows Health Benefits. Speaking Practice. At the Hotel. English Grammar. Verbs + -ING What’s in The News? Micro-green Study Shows Health Benefits. “Micro-greens” are tender young plants grown from the seed of certain herb, vegetable, and grain crops that can be clipped at the stem and eaten fresh within 2 weeks of germinating. Some chefs have touted the taste, texture, color, and delicate appearance of micro-greens, adding them to soups, salads, sandwiches, and main dishes. Micro-greens can also contain more nutrients than full-grown plants. Red cabbage micro-greens, in particular, have garnered attention for their potential to help protect against chronic diseases like cardiovascular disease, a leading cause of death in the United States. “Although micro-greens, such as those from red cabbage, have been reported to possess more nutrients [than mature plants] and are perceived to be ‘healthier,’ no known study has been conducted to evaluate whether consumption reduces cardiovascular disease risk factors,” according to Agricultural Research Service (ARS) chemist Thomas Wang and his co-authors in the December 2016 issue of the Journal of Agricultural and Food Chemistry. Speaking Practice. At the Hotel. Clerk: Yes, sir. May I help you? Tony: I have a reservation for tonight. Tony Davis. Clerk: Just a moment, please, while I check. That is correct. You have a reservation for a three ­room suite tonight. Tony: I’m afraid there’s been a mistake. I only asked for a single room, not a suite. Clerk: I’m sorry, Mr. Davis, but we have only the suite available. Your request arrived too late to reserve a single. There’s a large convention in town this week and we’re full up. Tony: Well, if that’s the way it is, I’ll have to take it. Clerk: Just sign the register here and I’ll have your bags sent up later. It’s suite 718. Language Notes May I help you? = May I serve you? We’re full up. = All of our rooms are taken or reserved. Three room suite = Three connected rooms. Suite = Pronounced the same as “Sweet”. Single room = One room. English Grammar. Verbs + -ING Often, certain words follow a certain pattern in English. This is called a “verb pattern”. Although, the examples below may have more than one verb pattern, it is more common to use one variant as opposed to another. Here are some common verbs in English that are followed by -ing. avoid You should avoid eating after 10 PM. enjoy I enjoy skiing, surfing, and playing tennis. finish Have you finished reading the newspaper yet? can’t stand I can’t stand going to parties where I don’t know anyone. don’t mind I don’t mind working overtime. look forward to I look forward to seeing you next week. practice I need to practice speaking English more often. spend (time) My roommate spends hours watching TV. stop He stopped smoking ten years ago. Read more here https://larisaenglishclub.com/pdf-resources/larisa-english-club-20-pdf-version/

Why did TransAsia Flight 222 veer off course and crash a mile short of Magong Airport? An examination of the wreckage doesn't provide the answer - but it does convince investigators to rule one... The latest in science, culture, and history from Smithsonian Channel.

Guest: Thomas D. Wang, MD, PhD Host: Mark DeLegge, MD Microscopic imaging of the digestive tract moves beyond examination of tissue at subcellular levels, helping us identify molecular regions in which to probe for dysplasia. Dr. Thomas Wang, assistant professor of medicine and biomedical engineering at the University of Michigan Medical School, details this 'biopsy inside the body' with host Dr. Mark DeLegge. How could this technology shape the future of GI practice? How does this differ from chromoendoscopy, autofluorescence, and other current technologies?

Guest: Thomas D. Wang, MD, PhD Host: Mark DeLegge, MD Microscopic imaging of the digestive tract moves beyond examination of tissue at subcellular levels, helping us identify molecular regions in which to probe for dysplasia. Dr. Thomas Wang, assistant professor of medicine and biomedical engineering at the University of Michigan Medical School, details this 'biopsy inside the body' with host Dr. Mark DeLegge. How could this technology shape the future of GI practice? How does this differ from chromoendoscopy, autofluorescence, and other current technologies?

Guest: Thomas Wang, MD Host: Gary Kohn, MD Cardiologist and investigator Dr. Thomas Wang of the Massachusetts General Hospital talks about his recent work on Vitamin D deficiency and the increased risk of cardiovascular disease.