Podcasts about sicam

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In occasione di Sicam 2022, il Salone Internazionale dei Componenti, Acessori e Semilavorati per l'Industria del Mobile, Zerica storica azienda all'avanguardia nella produzione di soluzioni per l'erogazione di acqua e bevande, presenta una serie di novità che hanno come obiettivo semplificare la vita in cucina ponendo l'attenzione sul connubio tra tecnologia e sostenibilità.A Pordenone, l'azienda di Termini Imerese, che da oltre 90 anni progetta e realizza un'ampia gamma di prodotti d'ultima generazione distribuiti da I&D, scommette sul futuro e la cucina interconnessa con una panoramica completa e versatile.

Consumption of berries, fruits and vegetables and mortality among 10,000 Men Followed for four decades Folkhalsan Research Center (Norway), June 17, 2022 Investigators from Folkhalsan Research Center in Norway found that consumption of berries, fruits and vegetables and mortality among 10,000 Norwegian men followed for four decades "The association between vegetable and fruit consumption and risk of cancer and cardiovascular disease (CVD) has been investigated by several studies, whereas fewer studies have examined consumption of vegetables and fruits in relation to all-cause mortality. Studies on berries, a rich source of antioxidants, are rare." "The purpose of the current study was to examine the association between intake of vegetables, fruits and berries (together and separately) and the risk of all-cause mortality and cause-specific mortality due to cancer and CVD and subtypes of these, in a cohort with very long follow-up. We used data from a population-based prospective Norwegian cohort study of 10,000 men.  Men who in total consumed vegetables, fruit and berries more than 27 times per month had an 8-10 % reduced risk of all-cause mortality compared with men with a lower consumption. They also had a 20 % reduced risk of stroke mortality. Consumption of fruit was inversely related to overall cancer mortality, with hazard rate ratios of 0.94, 0.84 and 0.79 in the second, third and firth quartile, respectively, compared with the first quartile." According to the news editors, the research concluded: "Increased consumption of vegetables, fruits and berries was associated with a delayed risk of all-cause mortality and of mortality due to cancer and stroke."       UA researchers discover component of cinnamon prevents colorectal cancer in mice University of Arizona, June 15, 2022 Research conducted at the University of Arizona College of Pharmacy and the UA Cancer Center indicates that a compound derived from cinnamon is a potent inhibitor of colorectal cancer. Georg Wondrak, Ph.D., recently completed a study in which they proved that adding cinnamaldehyde, the compound that gives cinnamon its distinctive flavor and smell, to the diet of mice protected the mice against colorectal cancer. In response to cinnamaldehyde, the animals' cells had acquired the ability to protect themselves against exposure to a carcinogen through detoxification and repair. Given cinnamon's important status as the third-most-consumed spice in the world,' Wondrak adds, 'there's relatively little research on its potential health benefits. If we can ascertain the positive effects of cinnamon, we would like to leverage this opportunity to potentially improve the health of people around the globe.' Drs. Wondrak and Zhang's study, 'Nrf2-dependent suppression of azoxymethane/dextrane sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde,' has been published in Cancer Prevention Research later this spring.         Lean tissue benefit of protein supplementation affirmed Universidade Federal do Rio Grande do Sul (Brazil), June 17, 2022.  A “systematic review of systematic reviews” published  in Sports Medicine showed that the addition of protein supplementation to resistance training is associated with a greater increase in lean body mass (body mass minus fat mass) in comparison with resistance training alone.  Researchers in Brazil selected 46 studies in the meta-analyses involved a total of 2,925 men and women over 50 years of age. Supplemented groups received 12 to 40 grams of protein or 3 to 10 grams of amino acids while the control groups received a placebo or no supplementation. Among the 4 meta-analyses that evaluated lean body mass, 3 found a significant increase in association with resistance training plus protein supplementation compared to resistance training without supplementation. There was also a significant benefit for protein supplementation combined with training on muscle mass alone. “It is possible to conclude that protein supplementation associated with resistance training induces greater increases in lean body mass compared with resistance training alone in older participants. In addition, it is suggested that the effect of protein supplementation on lean body mass is extended to the increase in muscle mass, while no additional effect of protein supplementation was observed on muscle strength in older adults.”       Study shows inhaled toxic particles take direct route from lungs to brain University of Birmingham, June 20, 2022 Breathing in polluted air could lead to toxic particles being transported from lungs to brain, via the bloodstream—potentially contributing to brain disorders and neurological damage, a new study reveals. Scientists have discovered a possible direct pathway used by various inhaled fine particles through blood circulation with indications that, once there, the particles stay longer in the brain than in other main metabolic organs. The scientists revealed they had found various fine particles in human cerebrospinal fluids taken from patients who had experienced brain disorders—uncovering a process which may result in toxic particulate substances ending up in the brain. "The data suggests that up to eight times the number of fine particles may reach the brain by traveling, via the bloodstream, from the lungs than pass directly via the nose—adding new evidence on the relationship between air pollution and detrimental effects of such particles on the brain."   Turmeric: A Wellness Promoting Tonic At Low Doses, Research Reveals Ohio State University, June 12, 2022 A study published in the Nutrition Journal   holds great interest among those on the fence about using dietary supplements to improve the quality and perhaps length of their lives, but for which clinical proof is lacking. The study was conducted in healthy middle aged people (40–60 years old) with a low dose of curcumin (80 mg/day) in a fat soluble (lipidated) form.  Two groups of 19 subjects were given either curcumin or placebo for 4 weeks. Blood and saliva samples were taken before and after the 4 weeks and analyzed for the following blood and saliva measures relevant to health promotion The positive results were reported as follows: Curcumin lowered triglycerides, but not cholesterol (note: lowering cholesterol may harm human health). Curcumin increased plasma contents of nitric oxide, a molecule that can work against high blood pressure, as well as lowering plasma concentrations of sICAM, a molecule linked to atherosclerosis. Curcumin raised plasma myeloperoxidase concentrations, without raising C-reactive protein and ceruloplasmin values – a sign of normal and inflammation-related neutrophil function. Curcumin reduced salivary amylase activities, which are an indicator of sympathetic nervous system stress. Curcumin raised salivary radical scavenging capacities, an indicator of reduced oxidative stress.· Curcumin reduced plasma contents of beta amyloid protein, a marker for brain aging and Alzheimer's disease. Curcumin reduced ALT liver enzyme activities, a marker for liver injury.   Natural cocoa consumption: Potential to reduce atherogenic factors? University of North Texas, June 17, 2022 According to news reporting in University of North Texas, research stated, "Short-term consumption of flavanol-rich cocoa has been demonstrated to improve various facets of vascular health. The purpose of the present study was to determine the effect of 4 weeks of natural cocoa consumption on selected cardiovascular disease (CVD) biomarkers in young (19-35 years) women of differing body mass indices (BMI)." "Subjects (n=24) consumed a natural cocoa-containing product (12.7 g natural cocoa, 148 kcal/serving) or an isocaloric cocoa-free placebo daily for 4 weeks in a random, double-blind manner with a 2-week washout period between treatment arms.  Natural cocoa consumption resulted in a significant decrease in haptoglobin, EMP concentration and monocyte CD62L in obese compared to overweight and normal-weight subjects. Natural cocoa consumption regardless of BMI group was associated with an 18% increase in high-density lipoprotein and a 60% decrease in EMPs. Also, obese subjects experienced a 21% decrease in haptoglobin and a 24% decrease in monocyte CD62L expression in following 4 weeks of natural cocoa consumption. Collectively, these findings indicate that acute natural cocoa consumption was associated with decreased obesity-related disease risk."

A fair number of the patients I see are already eating a healthy diet but they’re still not feeling well. Once we delve deep into their history and their lives, it becomes very clear that stress is at the bedrock of their illness. It’s extremely frustrating to be eating well all the time but still experiencing symptoms. We know that stress shuts down digestion including suppression of stomach acid, bile flow, and pancreatic function. All of these are necessary for healthy digestion but if we’re stressed while we are eating, that healthy food we’re putting into our bodies won’t get digested properly and it may have some more interesting effects on the body. Stress also immediately changes the behavior of your gut bacteria which also influences how your food is digested and absorbed. I decided to look deeper into this connection and I found a very interesting paper entitled, “Depression, Daily Stressors, and Inflammatory Responses to High-Fat Meals: When Stress Overrides Healthier Food Choices.” The paper was published in the journal Molecular Psychiatry in March of 2017. Let’s dig in and break down what the researchers found. 58 healthy women with a mean age of 53 received either a high saturated fat meal or a high oleic sunflower oil meal. An inventory of stressful events was assessed prior to consuming the meal. The researchers found as expected that women without any prior day stressors showed increased signs of inflammation after the high saturated fat meal but no increase in inflammation after the sunflower oil meal. This is expected because too much saturated fat increases inflammation and monounsaturated oils that are high in oleic acid such as sunflower oil or olive oil do not increase inflammation when eaten in excess. In fact, olive oil has been shown in studies not to increase inflammation when eaten in excess and also it has been shown to decrease inflammation. However, any of the women who had prior day stressors showed an increase in inflammation after eating the high saturated fat meal as well as the high sunflower oil meal. The results looked identical after eating both types of fat. This clearly showed that if you have been under stress, eating fats that don’t increase inflammation such as sunflower or olive oil will still increase inflammation. They also found that the more daily stressors the subjects had leading up to the meals, the greater the levels of inflammation after the sunflower oil meal but not the saturated fat meal. So saturated fat had a cut-off effect when more stressors were accumulated. Additionally, any of the women who had a history of major depressive disorder showed an abnormal increase in blood pressure after the high-fat meal of both types. The authors go on to discuss how this increase in inflammation promotes plaquing of the arteries and can lead to diabetes by increasing insulin resistance. The authors also discuss the connection between a history of depression and how people respond to stressors. Those with any history of depression or PTSD show an amplified response to stressors compared to those without such history. Previous studies have also shown that marital stress can lead to higher insulin and triglyceride levels post-meal. What did they eat? The subjects at eggs, turkey sausage, biscuits, and gravy which contained 60 grams of fat, 59 grams of carbohydrates, and 36 grams of protein. The authors point out that these types of numbers are similar to that of a Burger King Double Whopper with cheese or a Big Mac cheeseburger and medium French fries. How was inflammation measured? Blood testing included CRP(c-reactive protein), serum amyloid A, sICAM-1, and sVCAM-1. SICAM-1 and sVCAM-1 are specific indicators of increased damage to arteries thus potentially leading to atherosclerosis. Dr. Hedberg’s Comments It is interesting that more daily stressors did not increased inflammation above a certain point in those who ate the high satu...

Derzeit gibt es keinen Parameter, der die Effizienz einer neoadjuvanten Chemotherapie bei Patientinnen mit Mammakarzinom sicher vorhersagen kann. Das Therapieansprechen kann erst nach Applikation mehrerer Chemotherapiezyklen anhand der Klinik und bildgebender Verfahren beurteilt werden. Eine präzise Beurteilung der biochemischen Reaktionen des Tumors auf die Therapie ist so nicht möglich. Aus diesem Grund sollte in dieser prospektiv angelegten Studie die Wertigkeit verschiedener zirkulierender Biomarker zur Vorhersage und frühzeitigen Beurteilung der Effizienz einer neoadjuvanten Chemotherapie bei Patientinnen mit Mammakarzinom untersucht werden. Mit MIF, sFAS, sICAM, tPAI-1, M30 und Nukleosomen wurden Biomarker ausgewählt, die apoptoseabhängig im Serum nachgewiesen werden können. Da die Apoptoserate bei malignen Erkrankungen dereguliert ist und durch Zytostatika gezielt beeinflusst wird, erschienen diese Apoptosemarker vielversprechend.

Adrian Sicam is a singer/songwriter/keyboardist who joins Mark in a car conversation en route to a function gig with their sometime musical home: the Hip Pocket Orchestra.  Ade and Mark discuss Ade's time at Syracuse University, the world of musical theatre, the legendary funk/spoken word band Neon Grandma (of which Adrian was a founding member), Star Island, Adrian's solo record "Hey Stranger," and the trials and tribulations of the living as an artist.  Music: "You Behave" (Shilansky), "Skylark" (Carmichael/Mercer, arr. Sicam/Shilansky), "I Cover the Waterfront", "Funky Lover" (Sicam, perf. by Neon Grandma), "So Low" (Sicam), "Jazz and Sushi" (Sicam), and "Change Your Mind" (Sicam)

SICAM - BOSCH

In questa puntata: Notizie buone dal mondo dell'automotive: inaugurato a Correggio il nuovo stabilimento SICAM, azienda leader dell'after market, del Gruppo BOSCH. Mondiale Rally - Comprensibile euforia in casa MINI per il ritorno della marca nel campionato mondiale rally. Nel servizio, la presentazione della vettura e del team a Oxford. Formula 1 – Reduce dalla vittoria nel GP della Malesia con Sebastian Vettel, la Red Bull - già prima anche nella classifica costruttori - ci riprova sulla pista di Shangai nel GP della Cina, terza prova del campionato. Nelle immagini che seguono Mark Weber, compagno di squadra del campione del mondo, illustra la geometria del tracciato. Formula 1 - Una Ferrari in salita, carente di podi, rincorre la sua prima vittoria che sembra essere ancora lontana. Stefano Domenicali, responsabile del team, invita i tifosi delle rosse ad avere un po' di pazienza. Formula 1 - I pro e i contro delle gomme Pirelli analizzati dai tecnici della Mercedes.

In questa puntata: Notizie buone dal mondo dell'automotive: inaugurato a Correggio il nuovo stabilimento SICAM, azienda leader dell'after market, del Gruppo BOSCH. Mondiale Rally - Comprensibile euforia in casa MINI per il ritorno della marca nel campionato mondiale rally. Nel servizio, la presentazione della vettura e del team a Oxford. Formula 1 – Reduce dalla vittoria nel GP della Malesia con Sebastian Vettel, la Red Bull - già prima anche nella classifica costruttori - ci riprova sulla pista di Shangai nel GP della Cina, terza prova del campionato. Nelle immagini che seguono Mark Weber, compagno di squadra del campione del mondo, illustra la geometria del tracciato. Formula 1 - Una Ferrari in salita, carente di podi, rincorre la sua prima vittoria che sembra essere ancora lontana. Stefano Domenicali, responsabile del team, invita i tifosi delle rosse ad avere un po' di pazienza. Formula 1 - I pro e i contro delle gomme Pirelli analizzati dai tecnici della Mercedes.

Eine genetische Komponente in der Ätiologie der Schizophrenie gilt durch genetische epidemiologische Studien als gesichert. In dieser Arbeit wurde eine Reihe von Kandidatengenstudien im Fall-Kontroll-Design durchgeführt. Basierend auf den zahlreichen Hinweisen auf eine Beteiligung des Immunsystems an der Ätiogenese und Pathophysiologie der Schizophrenie und speziell basierend auf der Hypothese zur Imbalance des Th1/Th2-Gleichgewichtes bei schizophrenen Patienten wählten wir als Kandidatengene solche aus, die für Zytokine kodieren, denen eine herausragende Rolle in der Th1/Th2-Balance und/oder in der antiviralen Abwehrreaktion des Körpers zukommt. Zudem untersuchten wir das für das Adhäsionsmolekül ICAM-1 kodierende Gen, nachdem eigene Voruntersuchungen auf eine veränderte Expression dieses Adhäsionsmoleküls bei schizophrenen Patienten hingewiesen hatten. In diesem Zusammenhang bestimmten wir erneut die sICAM-1 Serumkonzentration in einer Subgruppe von 70 schizophrenen Patienten und 129 gesunden Kontrollen und untersuchten die mögliche Assoziation mit dem ICAM-1 Genotyp. Insgesamt wurden 263 schizophrene Patienten und 275 gesunde Kontrollpersonen hinsichtlich der folgenden Kandidatengene untersucht: • IL-2 T-G SNP auf Position –330 in der Promotorregion (Chromosom 4q26-q27); IL-2 ist ein typisches Th1-Zytokin. • IL-6 G-A SNP auf Position –174 in der Promotorregion (Chromosom 7p21); IL-6 ist ein typisches Th2-Zytokin. • TNF-alpha G-A SNP auf Position –308 in der Promotorregion (Chromosom 6p21.3); TNF-alpha ist maßgeblich an der antiviralen Immunabwehr beteiligt. • ICAM-1 G-A auf Position 241 und A-G auf Position 469 in der kodierenden Region des Gens (Chromosom 19p13.3-p13.2); ICAM-1 ist wie oben beschrieben ein Adhäsionsmolekül. Bei der Untersuchung des T330G SNP des IL-2 Gens zeigte sich ein signifikant häufigeres Auftreten des homozygoten T-Allels bei schizophrenen Patienten als bei gesunden Kontrollpersonen (²=8,016; df=2; p=0,018). Die Untersuchung des G174A SNP in der Promotorregion des für IL-6 kodierenden Gens, des G308A Polymorphismus des TNF-α Gens, des A241G SNP sowie des A469G SNP des ICAM-1 Gens erbrachten keine signifikanten Unterschiede. Der Befund zum IL-2 –330 T-G SNP bestätigt die Hypothese, dass Polymorphismen in Genen die für Immunfaktoren kodieren, mit Schizophrenie assoziiert sind. Zudem sprechen die Ergebnisse zum TNF-alpha -308 G-A SNP und zum ICAM-1 241 G-A SNP für unterschiedliche (immun-)genetische Risikofaktoren bei männlichen und weiblichen schizophrenen Patienten. Unsere bereits publizierten Vorbefunde von erniedrigten Serumkonzentrationen von sICAM-1 bei schizophrenen Patienten ließen sich bestätigen. Zudem konnten wir unsere Arbeitshypothese, dass die erniedrigten sICAM-1 Konzentrationen bei schizophrenen Patienten auf einer genetischen Disposition im ICAM-1 Gen beruhen, nicht bestätigen. Es müssen also andere Faktoren, wie zum Beispiel ein krankheits-assoziierter Faktor bei schizophrenen Patienten, die erniedrigten Konzentrationen verursachen. In diesem Zusammenhang könnte das Überwiegen der Th2-artigen Immunabwehr die Ursache für die reduzierten sICAM-1 Konzentrationen bei Schizophrenie darstellen Die signifikant erniedrigte sICAM-1 Serumkonzentration bei gesunden Kontrollen, die das polymorphe A-Allel aufweisen, geben einen ersten Hinweis auf die Funktionalität des Polymorphismus

Objectives: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism ( SNP) of the ICAM-1 gene was described at position 241. The G --> A SNP results in a nonsynonymous amino acid exchange of the ICAM-1 protein, and the A allele was shown to be also associated with several immunological disorders like rheumatoid arthritis. Methods: We investigated 70 schizophrenic patients and 128 unrelated healthy control persons regarding the relationship between the serum levels of sICAM-1 and the ICAM-1 G214A polymorphism. Results: We were able to replicate our previous finding of reduced sICAM-1 levels in schizophrenia. Healthy control persons carrying the polymorphic A allele showed markedly lower sICAM-1 serum levels than carriers of the homozygous GG wild type ( p < 0.004). In contrast, no significant difference in the sICAM-1 serum levels were seen regarding the G241A genotype distribution in schizophrenic patients. Conclusion: We hypothesize that the biochemical effect of the G241A SNP is masked in schizophrenic patients, indicating a disease-related mechanism leading to reduced levels of sICAM-1 in schizophrenia. Copyright (C) 2005 S. Karger AG, Basel.

Background: The number of inducible adhesion molecules known to be involved in cell-mediated allograft rejection is still increasing. In addition, recent data describe complement activation during acute humoral allograft rejection. The aim of this study was to assess whether specific molecules from either pathway are excreted into urine and whether they can provide useful diagnostic tools for the monitoring of renal transplant recipients. Methods: Urinary concentrations of soluble adhesion molecules (sICAM-1, sVCAM-1) and of the complement degradation product C4d were determined by standardized ELISA technique in 75 recipients of renal allografts and 29 healthy controls. Patient samples were assigned to four categories according to clinical criteria: group 1: acute steroid-sensitive rejection (ASSR, n=14), group 2: acute steroid-resistant rejection (ASRR, n=12), group 3: chronic allograft dysfunction (CAD, n=20) and group 4: stable graft function (SGF, n=29). Results: All patients with rejection episodes (groups 1-3) had significantly higher values of urinary sC4d compared with healthy controls and patients with stable graft function (p