Podcasts about crp

Matt Hatala of Prairie Rose Farms shares his unlikely path from adoption and military service to raising pasture pork in Iowa. He discusses regenerative hog production, farm marketing, local food systems, water quality, animal welfare, and why rebuilding agriculture requires courage, transparency, and healthier relationships with land, community, and risk.   hokseynativeseeds.com (for all your CRP, Pasture Mixes, Habitat Mixes, Native Seed, and more)   Iowa Cover Crop (for all your cover crop mixes, forage mixes, small grain mixes)

Heart disease is not only a man's disease. It is the number one killer of women, responsible for ten times more deaths than breast cancer. And yet most women have never had a real conversation about their cardiovascular risk, because the medical system was not built to catch it in them.Dr. Martha Gulati is the Director of Preventive Cardiology and Associate Director of the Barbra Streisand Women's Heart Center at Cedars-Sinai, Director of the Davis Women's Heart Center at Houston Methodist, and author of Saving Women's Hearts. Her own quote has become one of the most cited lines in women's cardiology: "Heart disease is the number one killer of women, but lack of awareness is a close second."This conversation goes into how the female heart develops disease differently, why women's symptoms get dismissed even when they use the words chest pain, and the pregnancy complications, hormonal history, and inflammatory conditions that quietly raise cardiovascular risk for decades before anything shows up on a standard panel.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women's health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you'll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.⁠https://kayla-barnes-lentz.circle.so/female-longevity-community⁠If you're already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.⁠https://branchbasics.com/KAYLA15⁠ What we cover:How women's heart attack symptoms differ from men and why they still get dismissed in the ERWhy women wait longer, receive fewer tests, and are less likely to see a cardiologist when they arrive with chest painThe labs every woman should ask for, including LP(a), high-sensitivity CRP, and ApoB, with specific reference rangesWhy women get more cardiovascular benefit per minute of exercise than men, and what the exercise prescription actually looks likeMediterranean diet, hidden salt, sleep, and the lifestyle foundations that move the needleConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comConnect with Dr. Marth Gulati:Website: https://www.drmarthagulati.com/Instagram: https://www.instagram.com/drmarthagulatiLinkedIn: https://www.linkedin.com/in/martha-gulati-9b410496/Her Book (Saving Women's Hearts): https://www.drmarthagulati.com/general-2 #WomensHealth #HeartDisease #WomensHeartHealth #Cardiology #FemaleLongevity #HeartHealth #LongevityPodcast #PreventiveCardiology #HeartDiseaseInWomen #WomensCardiology #LongevityOptimization #KaylaBarnesLentz #HeartHealthForWomen #FemaleHealth #MarthаGulati

In this Coffee Time episode, Nicolas, Kent, and Riley debate whether the Midwest really feeds the world, dig into commodity calories, exports, food security, environmental tradeoffs, and what prairie, local food, grazing, and conservation minded choices might mean for Iowa's future.   Hoksey Native Seeds (for all your native seed needs: CRP, backyard pollinator, habitat, native pasture, and more)   MckayInsAgency.com (for all your insurance and financial planning needs)   BirdHuntingSupply.com (for all your bird hunting supplies and bird dog supplies)

Send us Fan MailIn this Journal Club episode, Daphna reviews a retrospective cohort study from Istanbul examining clinical, laboratory, and ultrasound factors associated with UTI in neonates hospitalized for unexplained hyperbilirubinemia. Among 96 term and near-term infants, 31% had culture-proven UTIs, a striking prevalence. Pathological renal ultrasound findings were independently associated with UTI, with affected neonates 4.6 times more likely to have a concurrent infection. Notably, standard laboratory markers including CRP and white blood cell count failed to distinguish UTI-positive from UTI-negative infants. The findings prompt a practical question: should urine culture be part of the routine workup for neonatal hyperbilirubinemia?----Renal ultrasonography findings are associated with urinary tract infection in neonates with asymptomatic hyperbilirubinemia. Sarı EE, Salihoğlu Ö.J Perinatol. 2026 Apr 13. doi: 10.1038/s41372-026-02686-x. Online ahead of print.PMID: 41975209Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Kay: Hi Dr. Cabral, Thanks for your very informative and interesting podcasts. How would you advise a post-menopausal 60 y.o family member if they tested low in ferritin (39.4 ng/mL)? I've read that this biomarker shows how much energy your body's cells have and low levels would result in symptoms like fatigue, low energy/easily tired and excessive hair shedding. This family member suffers from these symptoms. Other biomarkers revealed low AM cortisol and low LDL-C/ApoB ratio (1.1) and low basal metabolic rate of 1143 kcals/day. Although her TSH tested normal (1.3 uIU/mL), she's been on levothyroxine 75 mcg to manage hypothyroid. Her high-sensitivity CRP was not optimal at 1.49 mg/L and she has a family history of heart disease. What would you recommend for this family member? Thanks      Earl: I am currently on 20 mg of lisinopril daily. Also, my GFR is 62. Would either of these be a concern when considering creatine?       Alesi: Dr.Cabral, can you please explain Alpha-gal syndrom? Why does it happen, how to confirm it by testing and how would you approach it? Is it treatable? Thank you      Peter: Hello, Dr.Cabral. I am an integrative health practitioner and would like to thank you for helping me understand the underlying causes of human imbalances. There is one thing that makes no sense to me though…regarding IgG testing, why would you recommend to test every year? Why doesn't suffice to test once and simply stay away from intolerant food items? Why would these intolerances change? Also, in my country there are IgG4 vs IgG1-3 testing options, what are the differences? Thank you very much for your time and knowledge you share with us.       Dipali: Hi I want to start 7 days detox plan, I already did your minerals and heavy metal test, I got my results back. My question is I am taking berberine, oregano oil and magnesium citrate,( I am prediabetic my Hba1c is 6.2)do I need to stop before starting detox method. Thanks       Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3774 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Hal Herring joins The Prairie Farm Podcast to unpack American Prairie, grazing permits, public lands, ranching culture, and the hard history behind conservation in the West.   hokseynativeseeds.com (for all your CRP, backyard prairie, Hunting Habitat, native grazing mixes, and more!) BirdHunterSupply.com (for all your bird hunting supplies and bird dog supplies)

Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.

In part 1 of our FAQ mini series, we answer the following questions. 1. How long does it take for a prairie planting to become established? 2. How do I prepare the site for planting? 3. Is tilling or breaking up the soil recommended before planting? 4. When is the best time of year to sow native prairie seeds? 5. How do I handle maintenance (mowing) in the first year?  6. How high should I mow in the first two years, and when should I stop? 7. Should I water or fertilize my newly planted prairie?   hokseynativeseeds.com (for all your CRP, backyard prairie, native wildflowers and grasses, hunting habitat, and more)   Iowa Cover Crop (for all your cover crop, waterway mixes, small grains, and more)   McKay Insurance (for all your insurance and financial planning needs)

L'idée que l'humeur se joue uniquement « dans la tête » est en train de vieillir.Depuis une quinzaine d'années, la recherche documente un lien robuste entre l'inflammation chronique de bas grade et les troubles de l'humeur. Plusieurs études longitudinales montrent qu'un taux élevé de marqueurs inflammatoires (CRP, interleukine-6) précède l'apparition de symptômes dépressifs, parfois des années plus tard — ce qui suggère une direction causale, et pas seulement une coïncidence.Plus frappant encore : des essais contrôlés menés chez des patients atteints de maladies inflammatoires ont montré que les traitements anti-inflammatoires réduisaient les symptômes dépressifs, indépendamment de l'amélioration physique.Rien de tout cela ne réduit la tristesse à une seule cause. Mais ça nous rappelle une chose simple et profonde : le corps et l'esprit ne sont pas deux territoires séparés. Ce que vous faites pour apaiser votre système — votre sommeil, votre mouvement, votre stress — agit aussi sur votre humeur.Pour aller plus loin : — Khandaker et al., longitudinal studies CRP/IL-6 (méta-analyses, depuis 2013) — Kappelmann et al., Molecular Psychiatry (2018) — effet antidépresseur des traitements anti-cytokinesQu'est-ce qui, chez vous, mérite peut-être d'être écouté autrement en ce moment ?Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Registered dietitian nutritionist Leyla Muedin discusses the growing interest in biological age versus chronological age and explains that biological aging is modifiable through consistent lifestyle choices. She outlines common measurement tools and biomarkers, including epigenetic clocks (DNA methylation), telomere length, VO2 max, inflammatory markers, grip strength, and muscle mass, noting that genetics account for only about 25–40% of biological aging variation. Key interventions include regular aerobic and resistance exercise, protein-adequate nutrition to preserve muscle and prevent sarcopenia (with whey protein and leucine-rich foods noted), improved sleep, stress management, reducing processed foods and visceral fat, and lowering chronic inflammation (CRP, IL-6). She also reviews hormetic stressors such as sauna use and mentions red/near-infrared light and sun exposure without sunglasses. Leyla shares client examples showing biological age can worsen or improve, and encourages repeat testing after lifestyle changes.

In this conversation, Dr. Reza Ardalan sits down with Dr. Hugh Coyne, a London-based family medicine practitioner and the son of a pediatric dentist, who built Coyne Medical with his wife and clinical partner Dr. Lucy Coyne specifically to practice the kind of preventive medicine the NHS 10-minute appointment window does not allow. His training at Imperial College London and postgraduate work in obstetrics and gynecology, pediatric health, and sports medicine give him a panoramic view of the screening opportunities most dentists are sitting on without realizing it. Dr. Coyne walks through the short blood panel he would build into every dental practice: HbA1c for diabetes risk that directly changes wound healing and periodontal outcomes, highly sensitive CRP for the kind of cardiovascular inflammation a UK Biobank study of over 400,000 people linked to a 61% higher risk of cardiovascular death, vitamin D with the K2 pairing that keeps calcium out of arterial walls, renal function, and a full blood count. From there, Dr. Coyne and Dr. Ardalan move into the oral microbiome shift from pathogen elimination to ecosystem restoration, the role of P. gingivalis in rheumatoid arthritis through citrullinated protein antibodies, and the cardiometabolic markers most patients never get tested for, including apolipoprotein B and lipoprotein(a). The third act covers GLP-1 medications, the Gila monster origin story, the medieval cautionary tale of Sancho the Fat, and the dental-chair implications most patients will never volunteer on a health history form. In this Episode:  The short blood panel any dental practice can start with: HbA1c, highly sensitive CRP, vitamin D, renal function, and a full blood count Why vitamin D supplementation without vitamin K2 may direct calcium into the wrong tissues, including arterial walls How a UK Biobank study of more than 400,000 people linked elevated hs-CRP to a 61% higher risk of cardiovascular death in patients otherwise considered well What the 87% of patients open to in-chair screening tells you about how to introduce blood testing in your practice without losing trust The rule of halves for blood pressure, and why a 158 reading caught on a second visit can be profoundly consequential for a patient's long-term survival How the oral microbiome model has shifted from pathogen elimination to ecosystem restoration, and what that changes about prevention Why P. gingivalis turns up in rheumatoid arthritis tissue, and how oral pathogens correlate with colorectal, pancreatic, and esophageal cancers The bachelor-party analogy for apolipoprotein B and lipoprotein(a), and why every dentist should know their own Lp(a) number What every dental practice needs to know before sedating a patient on a GLP-1 medication   Dr. Hugh Coyne is a London-based GP and the co-founder, with his wife Dr. Lucy Coyne, of Coyne Medical, a family medicine practice focused on preventive care and the early detection of disease. Dr. Hugh Coyne trained at Imperial College London with postgraduate degrees in obstetrics and gynecology, pediatric health, and sports medicine, and is a featured speaker at the Wellness Dental Forum 2026. Find him on Instagram and TikTok at @drhughcoyne and the clinic at @coyne_medical. Want to go deeper on the oral–systemic connection? Dentistry & Whole-Body Health is a 3-part live CE series on reading the medical signals hiding in your patients' bloodwork — and knowing what to do with them. Session 1:  Hidden Signals · Saturday, November 7, 2026 The bloodwork your patients already have, read through a dentist's lens. HbA1c, hs-CRP, vitamin D, CBC — and when to monitor, pause, or refer. Session 2: Cardiovascular Clues · Saturday, November 21, 2026 The lipid markers most panels skip (ApoB, Lp(a)) and the oral–heart connection behind them. Yes — this is the bachelor-party one. Session 3: The New Weight Loss Era · Saturday, December 5, 2026 What GLP-1s are quietly doing to how your patients eat, metabolize, and heal — and the chairside adjustments that come with it. All 3-hour sessions run 8 AM PT / 11 AM ET / 4 PM UK, with 30-day recording access if you can't make it live. 9 AGD-PACE-approved CE credits across the series. Nothing here asks you to become a doctor — it gives you the medical layer that's already shaping your outcomes. Enrollment opens soon: $1,497 → Or try a single session — $625 More details coming soon!

In today's Friggin' Farm & Ranch Report for Thursday, May 28, 2026, I'm coming to you out of Yerington, Nevada with a full plate of cattle, policy, and bullshit to sort through. We talk: June live cattle 10 under cash while the 5‑Area cash price holds 260.45 and packers slow the chain. USDA's May Cattle on Feed report showing a record 1.99 million head on feed 180 days or more. Tyson's new 47 million‑dollar civil settlement on beef price‑fixing for commercial buyers — with the DOJ criminal probe still hanging out there. Trump's Argentina quota expansion and the 200‑day beef TRQ suspension that swing the foreign beef door wide open during a historically tight U.S. herd. The FTC's fresh investigation into fertilizer pricing — on top of DOJ — while anhydrous, DAP, MAP, UAN, and urea all sit more than 150% above 2020. Base acre elections, CRP emergency grazing, Nebraska wheat damage, and what that means if you run cows or farm ground. Tigers hurting, Brewers rolling, A's hanging around in the AL West, and an “On This Day” that runs from the Indian Removal Act to the Sierra Club and cloned horses. If this show is worth something to your operation, the best thing you can do is tell one neighbor who runs cows or farms ground and send them my way. Read the write‑up, get the transcript, and support the show over on Substack:

Dit is de 268e aflevering van de Slimmer Presteren Podcast, over sport, onderzoek en innovatie. In deze aflevering hebben Gerrit en Jurgen het over:Hoe maak je hoogtetraining toch succesvol volgens topcoach Guido VroemenINLEIDING:Vijf jaar geleden (afl. 16) trokken we een harde conclusie: een hoogtestage is vooral dure luchtfietserij. De beoogde effecten konden niet wetenschappelijk worden aangetoond. Maar de sportwetenschap staat niet stil. Deze week is onze vaste coach en sportarts Guido Vroemen de hele aflevering de hoofdgast. Hij is dé expert op het gebied van hoogtetraining en heeft een innovatieve, extreem pragmatische aanpak ontwikkeld.We bespreken het ‘kwaliteit vs prikkel' dilemma: Op hoogte lever je in op de absolute trainingskwaliteit (intervallen). Tenzij je heel bewust kiest voor protocollen zoals Live High, Train Low of gerichte, ultrakorte sprints (IHT/RSH).Bovendien stelt Guido dat het concept van 'non-responders' niet klopt; iedereen reageert op hoogte, maar de benodigde hypoxische prikkel (hoogte of zuurstofpercentage) verschilt simpelweg per individu.Ben jij klaar om te stoppen met gissen op de berg?Vragen die in deze aflevering worden beantwoord: 1. Wat zijn de directe fysiologische effecten van hoogte op het lichaam van een duursporter?Volgens sportarts Guido Vroemen reageert het lichaam direct op de lagere atmosferische druk op hoogte. Omdat de zuurstofmoleculen minder dicht op elkaar geperst zijn, daalt de drukverhouding in de longblaasjes. Dit zorgt voor een acute daling van de zuurstofverzadiging in het bloed. Als reactie hierop gaan de nieren direct het hormoon erytropoëtine (epo) aanmaken om het beenmerg te prikkelen tot de productie van extra rode bloedcellen. Dit fysiologische proces vraagt in de eerste week echter enorm veel energie van de atleet.2. Waarom is de sportwetenschap zo verdeeld over het daadwerkelijke nut van een hoogtestage?De verdeeldheid in de wetenschap komt volgens Guido Vroemen voort uit het feit dat traditioneel onderzoek vaak kijkt naar vaste protocollen en groepsgemiddelden. Hierdoor ontstond de misvatting van responders en non-responders. In de praktijk blijkt echter dat de benodigde hypoxische prikkel per individu sterk verschilt. Waar de ene duursporter al biologische aanpassingen vertoont op achttienhonderd meter, heeft de ander een veel grotere hoogte nodig. Zonder personalisatie van de hoogtetraining en het nauwkeurig meten van de totale dosis mislukken veel stages, wat de wisselende wetenschappelijke resultaten verklaart.3. Wat is het geheim achter een succesvolle hoogtetraining voor duursporters?Het succes van een hoogtetraining valt of staat met de totale hypoxische dosis, die Guido Vroemen uitdrukt in saturatie uren. Om een aantoonbare stijging van de totale hemoglobine massa te realiseren, moet een sporter minimaal drieduizend uur in een toestand van lagere zuurstofverzadiging doorbrengen. Dit betekent concreet dat een korter verblijf dan drie weken fysiologisch gezien te weinig oplevert. Minimaal eenentwintig dagen onafgebroken op ten minste tweeduizend meter hoogte verblijven is de harde fysiologische ondergrens voor echt prestatievoordeel.4. Waar moeten duursporters medisch gezien op letten voordat ze vertrekken naar hoogte?Guido Vroemen benadrukt dat een hoogtestage een fysiologische gok blijft zonder voorafgaand bloedonderzoek. De belangrijkste randvoorwaarde is een gevulde ijzervoorraad, aangezien ijzer de cruciale bouwsteen is voor de aanmaak van hemoglobine. De ferritinewaarde moet daarom minimaal boven de vijftig liggen. Daarnaast is absolute gezondheid vereist: de ontstekingswaarde CRP moet lager zijn dan één. Bij een sluimerende ontsteking blokkeert het lichaam namelijk de ijzeropname, waardoor de productie van nieuwe rode bloedcellen volledig stilvalt ondanks de ijle lucht.5. Welke rol kan hittetraining spelen bij het maximaliseren van het effect van hoogtetraining?Het fysiologische effect van een hoogtestage op de hemoglobine massa is erg vluchtig en verdwijnt na thuiskomst snel. Guido Vroemen adviseert daarom om direct na de stage te starten met hittetraining, bijvoorbeeld driemaal per week in de sauna. De hitte dwingt het lichaam om het bloedplasmavolume kunstmatig hoog te houden. Hierdoor blijven de nieuw aangemaakte rode bloedcellen aanzienlijk langer in stand. Daarnaast kan hittetraining voorafgaand aan de reis al ingezet worden om het bloedvolume te vergroten als slimme fysiologische voorbereiding.Handige bronnen en links:Invloed van de luchtdruk en weersomstandigheden op effect van een hoogtestage: https://pubmed.ncbi.nlm.nih.gov/41985554/Artikel van Jurgen in Skepsis (‘Luchtfietserij') waarin hij het gebrek aan wetenschappelijk bewijs voor het nut van de hoogtestage benoemt: https://skepsis.nl/luchtfietserij/Aflevering 16 waarin we kritisch waren op de gunstige effecten van een hoogtestage: https://slimmer-presteren-podcast.nl/seizoen-1/trainen-op-hoogte-zinvol-of-niet/Aflevering 227 over hittetraining om rode bloedcellen te kweken: https://slimmer-presteren-podcast.nl/seizoen-11/227-rode-bloedlichaampjes-kweken-door-hittetraining-zinvol-of-onzin/ —-De Slimmer Presteren Podcast is een initiatief van Gerrit Heijkoop en Jurgen van Teeffelen. Vanaf begin 2020 bespreken zij wekelijks een onderwerp op het gebied van sport, onderzoek en innovatie. Zie ook:WEB: https://slimmer-presteren-podcast.nlINSTAGRAM: https://www.instagram.com/SlimmerPodcastLinkedIn: https://www.linkedin.com/company/slimmer-presteren-podcastPODCAST PLAYERS: https://slimmer-presteren.captivate.fm/listenVRIEND VAN DE SHOW: https://vriendvandeshow.nl/slimmerpodcastMentioned in this episode:Cadeau: 15% korting met onze code 'slimmerpresteren'In december gingen we op bezoek bij het hoofdkwartier Thrive en leerden daar alles over bier waar je beter van wordt. (aflevering 249) Wie al weet hoe lekker dit Belgische alcoholvrije bier is: met kortingscode ‘slimmerpresteren' en ontvang je 15% korting op je hele bestelling. En je steunt tegelijkertijd onze podcast, want wij krijgen ook nog eens 10% over alle omzet met de code. https://www.thrivebeer.com/nl/collections Ideaal voor in de aanloop naar je volgende marathon of triathlon. (je mag deze code zo vaak gebruiken als je wil, en ook delen met anderen)Thrive Thrive

Andrew Di Alessandro of the U.S. Fish and Wildlife Service joins the Prairie Farm Podcast to discuss Neil Smith Refuge, prairie restoration, prescribed fire, bison and elk grazing, private lands conservation, funding challenges, and how landowners can connect money, recreation and legacy to meaningful habitat work across Iowa and Illinois.   Hoksey Native Seeds (for all your CRP, Backyard Prairie, Native Pasture, Hunting Mixes, and more)   McKay Insurance (for all your insurance and financial planning needs)   BirdHunterSupply.com (for all your bird hunting supply needs, and all your bird dog supply needs)

Send us Fan MailDeep-dive into a 2026 cardiology review paper claiming seed oils reduce inflammation, exposing misrepresentations of cited clinical trials, and detailing how oxidized Ω-6 fats trigger inflammation.Companion article: Click HERETOPICS DISCUSSED:Seed Oil Profiles: Typical seed oils like sunflower are high in linoleic acid (omega-6 PUFA), while canola is higher in monounsaturated fats and resembles olive oil.Review Paper Critique: The 2026 JACC review falsely claims sunflower oil reduce inflammation like olive oil, citing an RCT that showed benefits only for canola and olive.RCT Analysis: In Iranian women with metabolic issues, switching to canola or olive oil lowered CRP by increasing MUFA and decreasing PUFA intake; sunflower oil produced no change.CRP Biology: CRP responds to oxidized lipids and cellular damage patterns, rising with exercise or infection and marking oxidized Ω-6 metabolites in modern diets.Oxidized Lipids: Ω-6 fats in LDL and cardiolipin oxidize easily, generating 4-HNE, MDA, and other signals that trigger immune clearance, similar to bacterial threats.Sterile Inflammation: High dietary linoleic acid causes chronic immune activation without pathogens, potentially contributing to metabolic and cardiovascular issues.PRACTICAL TAKEAWAYS:Prioritize monounsaturated fats from olive or avocado oil over high-linoleic seed oils like standard sunflower or soybean for lower oxidative stress potential.Check labels for high-oleic versions of sunflower oil, which shift the profile toward monounsaturated fats.Evaluate nutrition claims by examining original studies and fatty acid compositions rather than accepting review summaries at face value.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

On this Coffee Time episode, Nicolas and Kent crack into the global nut industry (forgive the pun), from California almonds and pistachios to pecans, cashews, and peanuts. They talk water use, pollination, pricing, supply chains, and why legumes might matter more in native prairie establishment than we usually give them credit for here.   hokseynativeseeds.com (for all your CRP mixes, backyard prairie mixes, hunting mixes, and more)   Iowa Cover Crop (for all your cover crop and small grain and cool season forage needs)

A cardiologist who helped set national cholesterol and weight targets for 40 years now says those numbers can mislead. Richard M. Fleming, a physician specializing in cardiovascular and inflammatory disease, argues that weight loss on a GLP-1 does not automatically mean a patient is getting healthier, and that some patients who never lose a pound are already metabolically well. This episode is based on his article "GLP-1 agonists and weight loss: Treating the disease, not the number," published on KevinMD. You will hear why body mass index was never built to diagnose individuals, why inflammatory and thrombotic markers track disease more honestly than the scale, and how clinical trials from CAST to ACCORD have shown what happens when medicine treats the surrogate instead of the patient. He walks through which inflammation tests a primary care physician can run before, during, and after GLP-1 therapy, including high-sensitivity CRP, homocysteine, and fibrinogen. Hear why a 40-year insider says precision medicine requires precision measurement, not precision weighing. Partner with me on the KevinMD platform. With over three million monthly readers and half a million social media followers, I give you direct access to the doctors and patients who matter most. Whether you need a sponsored article, email campaign, video interview, or a spot right here on the podcast, I offer the trusted space your brand deserves to be heard. Let's work together to tell your story. PARTNER WITH KEVINMD → https://kevinmd.com/influencer SUBSCRIBE TO THE PODCAST → https://www.kevinmd.com/podcast RECOMMENDED BY KEVINMD → https://www.kevinmd.com/recommended

Welcome to the land podcast, a platform for people looking to educate themselves in the world of land ownership, land investing, staying up to date with current land trends in the Midwest, and hearing from industry experts and professionals.  On today's episode, we are back in the studio with Koby Kuhnen. We discuss: Coby bought his first hunting farm at 27 years old. He started with public land frustration and a long-term goal. Living at home helped him save aggressively after college. He looked at farms for years before buying the right one. The farm was bigger than planned but priced right. He used an ag-focused lender who understood land. His first moves were food, low pressure, and sanctuary. A major timber harvest reshaped the farm's future. CRP income helped, but he learned not to rely on it fully. His biggest advice to young buyers: pull the trigger. And so much more! Thanks again for all of the support from our partners—none of this would've been possible without them! - Buck Land Funding: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.firstbankers.com/bucklandfunding⁠⁠⁠⁠⁠⁠⁠⁠⁠ -Hawke Optics | Use Code WHTL for 15% off:⁠⁠⁠⁠⁠⁠⁠⁠ https://bit.ly/hawkeoptics_⁠⁠⁠⁠⁠⁠⁠⁠ -OnX:⁠⁠⁠⁠⁠⁠⁠⁠ https://bit.ly/onX_Hunt⁠⁠⁠⁠⁠⁠⁠⁠ -Painted Arrow: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠bit.ly/PaintedArrow⁠⁠⁠⁠⁠⁠⁠⁠ - Latitude Outdoors: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.latitudeoutdoors.com/⁠⁠⁠⁠⁠⁠⁠⁠ - Whitetail Master Academy ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.whitetailmasteracademy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - Use code '⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠HOFER' to save 10% off at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.theprairiefarm.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - Massive potential tax savings: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ASMLABS.Net⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Show Notes: Lilly Minkove shares her background in brand and strategy consulting, focusing on retail, beauty, and wellness. She discusses her time at McKinsey, Tapestry, and Louis Vuitton, emphasizing her work in the luxury sector. Lilly explains her transition from the corporate world to running ArtLogica Group, a boutique consulting practice focused on customer insights. Introduction to HeraSphere Lilly talks about her interest in health and wellness, which eclipsed her work in retail and luxury. She recounts attending a longevity talk by Dr. Darshan Shah, which sparked her interest in tracking biomarkers and consumer insights. Lilly describes the inception of HeraSphere, a women's health newsletter translating healthcare innovations into plain English. She highlights the importance of women's health, especially for those in perimenopause or menopause, and how her consulting experience translates to this new focus. The Five Pillars of Health Lilly outlines the five pillars of health: exercise and muscle, sleep, nutrition, brain health, and connection. She emphasizes the importance of strength training, noting that muscle is an anti-aging metabolic organ. She discusses the benefits of muscle, including anti-inflammatory proteins, insulin resistance, and bone density protection. The Critical Role of Sleep Lilly explains the critical role of sleep in brain function, immune system, and overall health. She discusses the importance of regularity and quality of sleep, noting that even one night of sleep deprivation can significantly impact natural killer cell activity. Lilly shares tips for improving sleep quality, such as maintaining a consistent sleep schedule, avoiding alcohol, and using a sleep tracker. The conversation turns to the impact of stress and anxiety on sleep and the importance of winding down before bed. The Impact of Sugar on the Body Lilly highlights the negative effects of sugar on the body, including inflammation, cardiovascular disease, and diabetes. She explains the concept of glucose spikes and how eating fiber, protein, and fat before carbohydrates can reduce their impact. Lilly emphasizes the importance of a diverse diet, recommending consuming 30 different types of plants and vegetables weekly and highlights the challenges of hidden sugars in processed foods. Maintaining Brain Health Lilly discusses the significance of brain health, noting that the brain consumes 20% of daily calories and requires continuous stimulation. She shares her experience with learning a new skill, cardio dance, and how it improves muscle memory and cognitive function. Lilly explains the link between midlife decisions and cognitive outcomes, emphasizing the importance of lifestyle measures in preventing Alzheimer's. Lilly elaborates on the benefits of keeping the brain active through learning and new skills. Community and Health Connection Lilly highlights the importance of social connections for overall health, citing a Harvard study on the mortality risk of social isolation. She discusses the decline of extended family households and the need for intentional efforts to maintain social connections. Lilly emphasizes the role of small interactions with people in the community in reducing loneliness and improving well-being. Lilly discusses the benefits of having a support system and the impact of feeling less isolated on health outcomes. The Complexity of the Wellness Industry Lilly explains her dual objectives: sharing knowledge with consumers and using consumer insights to inform her consulting practice. She offers services to help brands distill what their customers want and convey value effectively. Lilly highlights the complexity of the wellness industry and her expertise in understanding the female consumer. Measuring Health KPIs Lilly outlines key health metrics, starting with blood pressure and hemoglobin A1C, which measure metabolic efficiency and cardiovascular risk. She discusses C-reactive protein (CRP) as an indicator of systemic inflammation and its association with various diseases. Lilly explains fasting insulin and LDL cholesterol, noting their importance in measuring insulin resistance and cardiovascular health. She highlights the importance of bone density and body composition, recommending DEXA scans for accurate measurement. A Focus on Longevity Lilly discusses VO2 max, a measure of cardiovascular capacity and longevity, and the challenges of obtaining accurate measurements. She mentions the use of fitness trackers to estimate VO2 max and the benefits of regular monitoring. Lilly shares her personal practice of conducting twice-yearly health panels to track biomarkers and ensure overall well-being. Timestamps: 02:47: Transition to Women's Health and HeraSphere  06:48: Key Health Pillars: Exercise and Muscle  13:57: Sleep and Its Importance  23:57: Nutrition and Sugar Impact  29:53: Brain Health and Lifelong Learning  36:20: Connection and Social Support  38:32: Lilly's Services and Consumer Insights  41:08: Key Performance Indicators (KPIs) for Health  47:04: Advanced Health Metrics and Longevity  Links:  HeraSphere newsletter: https://herasphere.beehiiv.com/ HeraSphere website: https://herasphere.beehiiv.com/p/herasphere-24-become-the-ceo-of-your-health Consulting practice website: https://artlogicagroup.com/ This episode on Umbrex:    Unleashed is produced by Umbrex, which has a mission of connecting independent management consultants with one another, creating opportunities for members to meet, build relationships, and share lessons learned. Learn more at www.umbrex.com. *AI generated timestamps and show notes.  

Text Dr. Lenz any feedback or questions The 2026 Cholesterol Revolution: PREVENT Scores, Hidden Risk Markers, and CAC ScansThe script explains how 2026 ACC/AHA guideline changes aim to make heart attacks more preventable by shifting from short-term “10-year risk” thinking to “lower for longer,” precision prevention, and primordial prevention starting earlier in life. It critiques the older Pooled Cohort Equations for underestimating risk in younger people and introduces the PREVENT equation, which adds 30-year risk plus kidney, metabolic, and social factors. It highlights lipoprotein(a) as a largely genetic once-in-a-lifetime test and hs-CRP as an inflammation marker, and emphasizes coronary artery calcium (CAC) scoring as a tiebreaker for statin decisions (0, 1–99, ≥100). Cases illustrate these tools, including tighter LDL goals (

Mixed Evidence on Eggs and Heart Risk; Debunking Saturated Fat Myths and 'Making Tallow Great Again'; Saturated Fat vs. Seed Oils: What the Science Says; Low-Carb, High-Fat Diets Raise ApoB in Healthy People; Saturated Fat Increases Harmful Lipid Markers; Nutrition Builds Resilience: The SELFISH Framework; Cath Lab Cooking and Nutritional Intervention; Impact of Macronutrient Substitution on Heart Risk; Polyunsaturated Fats Reduce Heart Disease by 19%; Olive Oil and Whole Food Plant-Based Diet Comparison; Track ApoB and CRP, Not Just Cholesterol #HeartHealth #Cholesterol #LifestyleMedicine #HealthTalks

In this episode, I this episoe I discuss tree plantings. The philosophy behind if they're worht it? If the traditional approach of spray, burn, spray, plant 600 trees, and tubing is the most reliable approach or the approach of grass selective only herbicides with 1000 trees per acre with no tree tubes is more effective ecspcially as early successional habitat. I go into detail of my own tree planting for the family farm consisting of 5.5 acres of CRP with 622 trees per acres totalling up to 3421 trees total with 275 tree tubes. Tree plantings are nostalgic for conservationists and land owners alike, but the prep work that goes into a planting is no easy undertaking. I hope you enjoy this episode: if you have any questions for this topic or future topics please email:JKnox0623@gmail.comReal Estatehttps://www.basecampcountry.com/agent-jesse-knox/Jesse.Knox@basecampcountry.com

Welcome to the land podcast, a platform for people looking to educate themselves in the world of land ownership, land investing, staying up to date with current land trends in the Midwest, and hearing from industry experts and professionals.  On today's episode, we are back in the studio with Steve Hanson. We discuss: Shed trespassing is becoming more organized. Social media helped identify the trespasser quickly. Trail cameras are changing trespassing enforcement. Many landowners view sheds as personal property. CRP rates have softened in recent years. CSP funding appears stronger in the new Farm Bill. Habitat-focused CRP projects can benefit both parties. Water quality is becoming a bigger conservation focus. Forestry incentives may become more important nationally. Iowa land prices appear stable after major growth years. And so much more! Thanks again for all of the support from our partners—none of this would've been possible without them! - Buck Land Funding: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.firstbankers.com/bucklandfunding⁠⁠⁠⁠⁠⁠⁠⁠ -Hawke Optics | Use Code WHTL for 15% off:⁠⁠⁠⁠⁠⁠⁠ https://bit.ly/hawkeoptics_⁠⁠⁠⁠⁠⁠⁠ -OnX:⁠⁠⁠⁠⁠⁠⁠ https://bit.ly/onX_Hunt⁠⁠⁠⁠⁠⁠⁠ -Painted Arrow: ⁠⁠⁠⁠⁠⁠⁠⁠⁠bit.ly/PaintedArrow⁠⁠⁠⁠⁠⁠⁠ - Latitude Outdoors: ⁠⁠⁠⁠⁠⁠⁠https://www.latitudeoutdoors.com/⁠⁠⁠⁠⁠⁠⁠ - Whitetail Master Academy ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.whitetailmasteracademy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - Use code '⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠HOFER' to save 10% off at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.theprairiefarm.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - Massive potential tax savings: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ASMLABS.Net⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

What do your annual lab markers mean and are you getting a thorough assessment of your health? In this podcast, Ali Miller RD, walks through 47 essential biomarkers in the Naturally Nourished Comprehensive Wellness Panel. You will learn about the status of your white blood cells and red blood cells, markers of chronic infection, anemia, and even indicators of parasite activity. Ali will unpack in detail a comprehensive metabolic panel so you understand the fasting glucose and dawn phenomenon connection, markers of liver and kidney health, and how to support detoxification as well as further assess function with GGT and uric acid.   Beyond typical cholesterol markers and the ideal range, learn about the importance of ratios and other added markers such as homocysteine, ApoB, and CRP. Understand the blood sugar story connecting the dots of fasting glucose, fasting insulin, HgbA1C% and other ways to bring blood sugar levels into ideal range to support body fat burn. Learn about functional ranges of thyroid markers and food-as-medicine for iodine, selenium, and zinc.    Links: The Naturally Nourished Comprehensive Wellness panel is just $295 and includes a customized lab review with a functional nutritionist. Use LAB25 to save $25 off now!

Allen Miller of Tower Rock Ranch in Mansfield, Washington was the 2023 NCBA Environmental Stewardship Award regional winner. His family has run cattle on the same Douglas County ground since 1883. Allen joins Tip to talk about blending the art and science of range management on a 15,000-acre operation reshaped by five major wildfires in just 14 years. Allen shares hard-earned lessons on rotational grazing, post-fire rest and deferment, the payoff of 125 miles of new fence, and how Sage Grouse Initiative water infrastructure and remote tank monitors have transformed cattle distribution across rocky, water-scarce country. The conversation closes with candid thoughts on riparian fencing, CRP's unintended consequences, the promise of virtual fence and GPS ear tags, and Allen's advice to the next generation of agency professionals: come in humbly, listen first, and learn alongside the ranchers you're trying to help. Music by Lewis Roise. Support for The Art of Range comes from RanchBot and the Western Extension Risk Management Education Center. Visit the episode page at artofrange.com for the transcript and links to resources mentioned in this interview.

The episode explains that inflammation is a necessary survival mechanism, with acute inflammation supporting healing, while chronic inflammation drives chronic disease. It outlines major contributors to chronic inflammation including visceral fat (with fasting insulin as a proxy for insulin resistance), poor sleep and sleep apnea, ultra-processed foods, sedentary behavior, overtraining, chronic psychological stress, poor oral health, gut dysbiosis/barrier issues, smoking, alcohol, pollution, autoimmune disease, and chronic infection. The host reviews biomarkers to discuss with a physician such as high-sensitivity CRP, ESR, ferritin, WBC and neutrophil-to-lymphocyte ratio, fasting insulin, ApoB, omega-3 index/omega-6:omega-3 ratio, and homocysteine. Chronic inflammation is linked to cardiovascular disease, depression/anhedonia, brain fog, autoimmune disease risk, cancer mechanisms, skin aging, erectile dysfunction, and chronic pain. Treatment focuses on lifestyle (notably treating sleep apnea, sleep optimization, fat loss, exercise, oral health, omega-3 intake, sauna, stress regulation, circadian rhythm), selected supplements (vitamin D if deficient, curcumin, boswellia, ginger, garlic, olive oil polyphenols, sulforaphane, magnesium/glycine, taurine, NAC, quercetin, probiotics, creatine), and brief discussion of drugs including GLP-1 agonists, colchicine, NSAIDs, corticosteroids, and biologics.   Chronic inflammation https://www.ncbi.nlm.nih.gov/books/NBK493173/ C-reactive protein test https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/ ESR blood test https://medlineplus.gov/lab-tests/erythrocyte-sedimentation-rate-esr/ Ferritin blood test https://medlineplus.gov/lab-tests/ferritin-blood-test/ Homocysteine test https://medlineplus.gov/lab-tests/homocysteine-test/ ApoB test https://my.clevelandclinic.org/health/diagnostics/24992-apolipoprotein-b-test Insulin resistance https://www.ncbi.nlm.nih.gov/books/NBK507839/ Obstructive sleep apnea https://medlineplus.gov/ency/article/000811.htm CPAP therapy https://medlineplus.gov/ency/article/001916.htm Sleep hygiene https://www.cdc.gov/sleep/about_sleep/sleep_hygiene.html Physical activity guidelines https://www.cdc.gov/physical-activity-basics/guidelines/adults.html Ultra-processed foods https://pmc.ncbi.nlm.nih.gov/articles/PMC10831891/ Gum disease https://www.cdc.gov/oral-health/about/gum-periodontal-disease.html Gut microbiome https://www.nccih.nih.gov/health/gut-microbiome-what-you-need-to-know Fiber https://www.hsph.harvard.edu/nutritionsource/carbohydrates/fiber/ Autoimmune diseases https://medlineplus.gov/autoimmunediseases.html Inflammation and heart disease https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/inflammation-and-heart-disease Inflammation and depression https://pmc.ncbi.nlm.nih.gov/articles/PMC4566946/ Cancer and chronic inflammation https://www.cancer.gov/about-cancer/causes-prevention/risk/chronic-inflammation Omega-3 supplements https://www.nccih.nih.gov/health/omega3-supplements-what-you-need-to-know   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 Inflammation Basics 01:24 Acute Versus Chronic 03:29 Chronic Disease Link 03:52 Visceral Fat Driver 06:06 Sleep And Apnea 12:33 Food And Movement 16:02 Stress And Oral Health 18:17 Gut And Fiber 21:17 Toxins Autoimmune Infection 26:05 Inflammation Biomarkers 27:13 Inflammation Blood Markers 28:37 Ferritin Iron Balance 30:07 Metabolic Cardio Labs 32:08 Omega 3 Index Insights 34:07 Homocysteine Risks 34:58 Why Inflammation Matters 41:07 Lifestyle Fixes 46:24 Supplement Options 54:36 Medication Overview 57:36 Final Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Brain fog, anxiety, low mood and memory slips are often brushed off as “stress” or “menopause” until life starts shrinking. We sit down with degree-qualified functional nutritionist Jo Greben to challenge that story and unpack a more useful lens: brain health as a bioenergetic problem where mitochondria, inflammation and fuel supply shape how well we think, feel and sleep.Jo shares what pulled her into dementia prevention and cognitive optimisation, including the impact of family history, brain injury, and seeing reversal-focused research that pushes beyond the outdated “nothing can be done” narrative. We talk about why genetics like ApoE4 raise risk but don't write your future, and why a proper assessment has to look at hormones, toxins, gut-brain signalling, oxidative stress, neuroinflammation and the small details that most rushed consults miss.You'll also hear practical prevention strategies you can start early: better sleep hygiene, smarter exercise with strength training, protein needs in perimenopause and menopause, and how to have a better conversation with your GP about tests that matter such as homocysteine, B vitamins, vitamin D and high-sensitivity CRP. We finish with clinician-loved tools that support calm and cognition, including saffron, L-theanine, creatine and nicotinamide riboside (NR), plus a case study where addressing mould exposure helped reverse a frightening cognitive trajectory.If you care about dementia prevention, mental health, cognitive resilience and healthy ageing, hit play, share this with a friend who's been dismissed, and subscribe so you don't miss what's next. If you found it helpful, leave a review and tell us what brain-health question you want answered next.Shownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.auFollow us on SocialsInstagram: DesignsforhealthausFacebook: DesignsforhealthausDISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health

FSA Communication from the County to D.C. 2026 Kansas Wheat Tour Diarrhea in Calves   00:01:05 – FSA Communication from the County to D.C.: The show starts off with David Schemm, Kansas Farm Service Agency state executive director, as he explains grassland CRP, livestock forage program and how communication happens between counties and the Capitol. Farmers.gov   00:12:05 – 2026 Kansas Wheat Tour: Romulo Lollato, K-State professor in agronomy and wheat production specialist, continues the show sharing insight from the 2026 Kansas Wheat Tour that is happening this week across Kansas.    00:23:05  – Diarrhea in Calves: Brad White, Bob Larson, Phillip Lancaster and Scott Fritz with the Beef Cattle Institute end the show with part of their Cattle Chat podcast where they discuss causes of diarrhea in calves.  BCI Cattle Chat Podcast Bovine Science with BCI Podcast Email BCI at bci@ksu.edu     Send comments, questions or requests for copies of past programs to ksrenews@ksu.edu.   Agriculture Today is a daily program featuring Kansas State University agricultural specialists and other experts examining ag issues facing Kansas and the nation. It is hosted by Shelby Varner and distributed to radio stations throughout Kansas and as a daily podcast.   K‑State Extension is a short name for the Kansas State University Cooperative Extension Service, a program designed to generate and distribute useful knowledge for the well‑being of Kansans. Supported by county, state, federal and private funds, the program has county Extension offices statewide. Its headquarters is on the K‑State campus in Manhattan. For more information, visit Extension.ksu.edu. K-State Extension is an equal opportunity provider and employer.

Conservation isn't just about habitat — it's about people, relationships, and showing up when decisions are being made.In this episode, host Dr. Mike Brasher sits down with Bill Cooksey, Partnerships Program Leader for the Tennessee Wildlife Federation, to talk about a career spent at the intersection of conservation, policy, industry, and grassroots advocacy. Bill brings decades of experience from Avery Outdoors, National Wildlife Federation, and now TWF, offering a unique perspective on how conservation decisions actually get made — and why personal relationships still matter more than emails, posts, or press releases.The conversation spans conservation advocacy, wildlife policy, changes in the hunting community, misinformation, and how sportsmen can still shape the future if they're willing to engage directly.In this episode, listeners will hear about:Bill Cooksey's path through the outdoor industry, conservation NGOs, and policyThe role of state wildlife federations and how they differ from national organizationsWhy conservation advocacy is ultimately about relationships and trust“Pick up the damn phone” — why real conversations still move the needleHow sportsmen influence policy at the state and federal levelsProtecting hunting rights through proactive engagementA landmark Tennessee case involving duck hunters and municipal restrictionsWhy misinformation spreads faster than science — and how to respond productivelyChanges in how hunters get information and engage with conservationThe decline of CRP, habitat loss, and consequences for duck populationsThe chronic underfunding of the U.S. Fish and Wildlife ServiceWhy engagement — not social media outrage — creates real impactPractical advice for contacting legislators and making your voice heardReasons for optimism about the future of waterfowl conservationThis episode is a reminder that conservation success still depends on individuals willing to speak up, build relationships, and advocate for the resources they care about.SPONSORS:Purina Pro Plan: The official performance dog food of Ducks UnlimitedWhether you're a seasoned hunter or just getting started, this episode is packed with valuable insights into the world of waterfowl hunting and conservation.Bird Dog Whiskey and Cocktails:Whether you're winding down with your best friend, or celebrating with your favorite crew, Bird Dog brings award-winning flavor to every moment. Enjoy responsibly.

Today, I'm thrilled to welcome Dr. Nasha Winters back to the show for part two of our powerful conversation. As a trailblazer in integrative oncology and a passionate advocate for the “metabolic terrain” approach to health, Dr. Winters brings both deep expertise and a truly holistic perspective to the complex world of cancer and longevity. In this episode, she doesn't just share concepts—she takes us into the heart of what it means to test, assess, and address our own health in real life, especially when we're facing major diagnoses and difficult decisions. Episode Timestamps: Welcome & Introduction to Longevity Podcast ... 00:00:00 Metabolic Terrain Concept & Mitochondrial Health ... 00:05:00 The Test, Assess, Address Framework ... 00:08:08 Readiness, Honest Audit, and Lifestyle Evaluation ... 00:08:43 The Ten Terrain Drops in Cancer & Health ... 00:14:09 Emotional Foundations for Healing ... 00:15:01 Essential Lab Markers and the “Trifecta” ... 00:16:52 Affordable, Early Detection Labs—CBC, CRP, LDH, ESR ... 00:17:32 Shift Work, Circadian Health, and Mitigating Strategies ... 00:29:11 Handling Overwhelm: Prioritizing Fundamentals ... 00:37:45 Prevention Myths: Sun, Meat, and Food Access ... 00:42:26 Home-Cooked Food & Community's Healing Power ... 00:51:16 Behaviors That Seem Healthy But Aren't (e.g., Excess Cardio) ... 00:54:55 Age-Specific Advice and Building Longevity ... 00:56:25 Cancer, Metabolic Flexibility, and Biomarker “Under Five” Rule ... 01:02:32 Integrative Oncology's Strengths & Misconceptions ... 01:08:48 Risks of Extreme Alternative or Mainstream Approaches ... 01:12:58 Post-2020: Changing Health Trends & Immune Patterns ... 01:17:03 Hope for the Future & Patient Empowerment ... 01:24:02 Our Amazing Sponsors: STEMREGEN by Stemregen - A daily formula designed to support your body's natural repair systems by helping release your own stem cells into circulation, supporting recovery, resilience, and whole-body renewal at the source. Visit stemregen.co/NAT15 and use code NAT15. https://stemregen.co/NAT15 Vampire Exosome by Young Goose - A next-generation serum packed with three trillion PRP-derived exosomes and RejuvNAD to support collagen production and skin renewal at the cellular level—helping results build over time instead of fading fast. Shop HERE and use code NAT10. Bioregulators by Nature's Marvels - targeted peptides designed to support cellular signaling and renewal across key systems like circadian rhythm, immune function, and vascular health as part of a foundational longevity stack; head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

RURAL AMERICA UNDER PRESSURE: FARMING, HEALTH, POLITICS, AND THE FIGHT FOR LOCAL COMMUNITIES On this episode of Rural Route with Trent Loos, Casey Yager from Illinois joins the conversation for a powerful discussion about the growing challenges facing rural America. Trent and Casey break down major issues impacting farmers, ranchers, and small-town communities, including wildlife management, shrinking pasture land, government conservation programs, rising farming costs, and the future of agriculture in the Midwest. They examine how deer populations, turkey decline, and CRP land policies are changing the landscape in Illinois while questioning whether current conservation efforts are truly helping rural ecosystems. The conversation also dives into Chronic Wasting Disease in deer populations, political corruption, massive campaign spending, low voter turnout, and the deep divide between urban and rural America. Casey shares his frustration with political chaos and explains why he believes people should focus more on family, local communities, and personal responsibility instead of nonstop national outrage. Trent and Casey also discuss health concerns ranging from tick outbreaks and alpha-gal syndrome to the importance of minerals, iodine, and nutrition. Casey opens up about his personal health transformation after overcoming severe back pain through dietary changes centered on meat and water, while also discussing the role of animal fats, protein, and modern nutrition in long-term health. The episode closes with an inside look at the booming demand for fencing in Illinois as cattle producers convert cropland back to grassland, along with concerns about strict Illinois gun laws, child safety, and preserving rural values for the next generation.

*The debate continues over cow herd rebuilding.   *The Farm Service Agency is now accepting applications for grasslands CRP.  *The Texas Corn Producers Association is applauding the introduction of a bill to lower fertilizer prices. *Texas High Plains farmers may see a new disease threat this year.  *The Army Corps of Engineers is working on many water projects.  *The House is expected to take up E15 legislation soon.*May is here and farming activity is busy on the Texas Rolling Plains.*Moving cattle soon after breeding is not a good idea.

Your doctor orders a lipid panel every year — but 3 cheap blood tests predict heart disease, diabetes, and even dementia far better than cholesterol, and most doctors never order them. In this episode, Robert Lufkin MD walks through fasting insulin + HOMA-IR, homocysteine, and high-sensitivity CRP — three tests that together cost about $60, take one blood draw, and catch the metabolic dysfunction a standard lipid panel systematically misses. CHAPTERS: 00:00 — The 3 Blood Tests Your Doctor Isn't Ordering 00:40 — Part 1: Fasting Insulin and HOMA-IR 01:15 — How Insulin Resistance Hides for 10–15 Years 01:45 — HOMA-IR vs Glucose: What 516,000 People Revealed 02:05 — 59% Higher Cardiovascular Risk in the 2023 ATVB Study 02:45 — Optimal Fasting Insulin: Why 5–8 Beats the Lab's "25" 03:05 — Part 2: Homocysteine and the MTHFR Connection 03:35 — How Homocysteine Damages Your Arteries (6 Mechanisms) 03:50 — 60% Higher Stroke Risk and 48% Alzheimer's Risk 04:35 — The Oxford VITACOG Trial: 53% Less Brain Atrophy 05:05 — Part 3: High-Sensitivity CRP and Inflammatory Plaque 05:40 — The JUPITER Trial: 44% Drop in Cardiac Events 06:15 — UK Biobank: Why hs-CRP Beats LDL Cholesterol 06:50 — AHA Risk Categories for hs-CRP Since 2003 07:15 — Part 4: The Metabolic Picture (Why Cholesterol Is the Wrong Target) 07:50 — 3 Tests, $60, One Blood Draw — The Full Framework KEY TAKEAWAYS: Fasting insulin + HOMA-IR catches insulin resistance a decade before glucose goes abnormal — optimal is below 5–8, not the lab's reference range of 25 Every 5 µmol/L rise in homocysteine raises coronary artery disease risk 20–30% and stroke risk 60%, independent of cholesterol hs-CRP predicted cardiovascular events better than LDL in a 322,000-person UK Biobank analysis — yet fewer than 10% of cardiac panels order it Cardiovascular disease, type 2 diabetes, and dementia share the same upstream driver: metabolic dysfunction, not cholesterol All three tests together cost roughly $60 and come from a single blood draw LINKS:

Sleep and weight gain are directly connected. Poor sleep disrupts hormones, raises blood sugar, tanks testosterone and estrogen, causes fatty liver, and wrecks your gut. If you've been doing everything right and the scale won't move, your sleep could be the missing link. FEATURED PRODUCT Chill by MSW Nutrition is a powdered drink mix formulated to support your body's natural calming chemistry — exactly what's needed when chronic stress and cortisol overload are stealing your sleep. Featuring GABA, L-Theanine, myo-Inositol, Taurine, and Magnesium, Chill helps balance neurotransmitters, quiet the nervous system, and promote the deep, restorative sleep your hormones, metabolism, and weight depend on — all five mechanisms discussed in this episode.

This week's stories: *Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30% Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens — and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your immune system requires microbial exposure to calibrate properly, what the hygiene hypothesis actually means for adults, and the dead-simple weekly habit that primes your innate immunity the same way. Sources: https://creators.yahoo.com/lifestyle/story/finland-replaced-artificial-playground-surfaces-with-natural-elements-like-mud-and-soil--and-the-results-surprised-even-researchers-184318556.html https://www.sciencedaily.com/releases/2026/04/mud-playground-immunity.htm *Mixing Exercise Types Cuts All-Cause Mortality Up to 40% in 170,000-Person Study A 30-year BMJ Medicine cohort study found that people who rotate at least three different types of exercise weekly see 19 to 40% lower all-cause mortality — and that benefit held independent of total training volume. Dave explains why variety is a distinct biological signal, not a motivation trick, and why grinding more of the same thing is leaving longevity gains on the table. Sources: https://bmjmedicine.bmj.com/content/early/2026/04/26/bmjmed-2025-001513 https://www.sciencedaily.com/releases/2026/04/260426012305.htm https://www.theguardian.com/society/2026/apr/26/exercise-diversity-mortality *Facial Aging Rate from Photos Predicts Cancer Survival Better Than Blood Biomarkers AI analysis of serial facial photos in 1,000+ cancer patients found that computed facial aging rate independently predicted five-year survival with a hazard ratio of 2.1 — outperforming CRP and other standard blood markers. Dave covers what the AI is actually reading in those photos, why your face is a more accurate biological ledger than most labs your doctor orders, and the free monthly habit that turns this into an early warning system. Sources: https://medicalxpress.com/news/2026-04-photos-reveal-faster-biological-aging.html https://www.nature.com/articles/s43587-026-00123-4 *Vibration Vest OsteoBoost Mimics Weight-Bearing Exercise to Rebuild Bone Density OsteoBoost raised $8M for a wearable vest delivering 30–50Hz vibrations to the spine and hips, triggering the same Wnt/β-catenin osteoblast pathway activated by mechanical loading — with early trials showing 2–5% bone mineral density gains in six months. Dave makes the case forwhy bone loss is one of the most underrated aging crises in the biohacking community, and who should be watching this category closely. Sources: https://longevity.technology/news/osteoboost-raises-8m-to-scale-bone-wearable/ https://www.crunchbase.com/organization/osteoboost *10+ States Advance Raw Milk Bills as H5N1 Hits 100+ Dairy Herds Legislation expanding raw milk access is moving in Arizona, Iowa, New Hampshire, and elsewhere — while the CDC flags H5N1 in over a hundred dairy herds with documented aerosol transmission concerns. Dave gives an honest read on where the freedom argument, the microbiome argument, and the current risk calculus actually stand in April 2026, and what more rigorous sourcing looks like right now. Sources: https://www.yahoo.com/news/articles/us-med--raw-milk-legislation-120124275.html https://www.cdc.gov/flu/avianflu/dairy.htm This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune priming, exercise science, biological age tracking, bone health, and real food risk assessment. Host Dave Asprey connects emerging clinical research, large-scale cohort data, and real-world protocols into actionable frameworks for extending healthspan and sharpening performance. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: mud playground immune system microbiome, soil bacteria skin diversity, hygiene hypothesis biohacking, exercise variety longevity, BMJ exercise mortality study, mixed training lifespan, facial aging rate cancer survival, biological age face AI, facial photo biomarker longevity, OsteoBoost vibration vest bone density, whole body vibration osteoporosis, bone mineral density wearable, raw milk H5N1 bird flu, raw milk legislation 2026, raw dairy safety biohacking, biohacking news, longevity research 2026, Dave Asprey weekly roundup Thank you to our sponsors! - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:20 – Dirt & Immune Training 02:22 – Exercise Variety & Longevity 04:16 – Facial Aging as a Health Biomarker 05:47 – Bone Loss & Vibration Tech 07:31 – Raw Milk & H5N1 Risk 09:20 – The Wrapup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episode Show NotesWe've been taught to believe that more exercise equals better health, stronger bodies, and faster results. This episode challenges that belief in a big way. Susan breaks down how pushing harder and training longer can actually backfire, leading to chronic inflammation, disrupted recovery, and even long-term health consequences that often go unnoticed.This conversation goes deeper than surface-level fitness advice. It connects the dots between genetics, lifestyle, and training patterns to show why two people can follow the exact same workout plan and experience completely different outcomes. From inflammatory gene responses to stress hormone regulation and recovery capacity, your body has a unique threshold, and ignoring it can quietly work against you.Susan also walks through how overtraining shows up beneath the surface, even when you feel “fine.” Blood markers, nervous system dysregulation, sleep disruption, and metabolic shifts all play a role in whether your body is adapting or breaking down. The goal isn't to stop moving, it's to train with precision, honoring your body's rhythms, recovery needs, and individual design.By the end of this episode, you'll have a new lens on exercise, one that prioritizes alignment over intensity, and sustainability over burnout. Because real progress doesn't come from doing more. It comes from doing what actually works for your body.In this episode:Why too much exercise can trigger chronic inflammation and slow recoveryHow genetics influence your response to stress, training, and inflammationThe role of stress hormones like cortisol in overtraining and burnoutKey gene variants (like COMT, IL-6, TNF-alpha) and what they mean for your bodyHow different health types respond to exercise, and why personalization mattersThe hidden signs of overtraining, even when you feel “healthy”Blood markers to watch for (fasting insulin, triglycerides, CRP, glucose)How chronobiology (timing) impacts performance and recoveryWhy recovery, not intensity, is where real progress happensHow to train smarter by aligning with your body's natural capacityRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/04/27/episode121/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Send us Fan MailDr. Lyubina Yankova, hospitalist at Yale, presents findings from a large retrospective multi-center analysis across 106 sites examining whether the combination of procalcitonin and C-reactive protein (CRP) can match or outperform the inflammatory marker combinations currently recommended by the 2021 AAP guidelines for risk-stratifying febrile infants between 8 and 60 days of age. She shares why this combination showed similar sensitivity but higher specificity for detecting invasive bacterial infections — meaning fewer false positives, fewer unnecessary lumbar punctures, and fewer unnecessary antibiotics. She also addresses the limitations of retrospective data, why preterm infants were excluded from this analysis and what future research in that population might look like, and what it would take for guideline committees to feel confident enough to incorporate this combination into routine practice.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

Early bird discounts for the San Francisco World's Fair, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock in ASAP!From near-universal AI tool adoption inside Shopify to internal systems for ML experimentation, auto-research, customer simulation, and ultra-low-latency search, Mikhail Parakhin joins us for a deep dive into what it actually looks like when a 20-year-old, $200B software company goes all-in on AI. We cover why Shopify has become much more vocal about its internal stack, what changed after the December model-quality inflection, and why the real bottleneck in AI coding is no longer generation, but review, CI/CD, and deployment stability.We also go inside Tangle, Tangent, SimGym, which are three major AI initiatives that Shopify is doing to make experimentation reproducible, optimization automatic, customer behavior simulatable, and search and catalog intelligence faster and cheaper at scale. Along the way, Mikhail explains UCP, Liquid AI, and why token budgets are directionally right but often measured badly, why AI-written code can still increase bugs in production, what makes Shopify's customer simulation defensible, and what he learned from the Sydney era at Bing.We discuss:* Mikhail's path from running a major Microsoft business unit spanning Windows, Edge, Bing, and ads to becoming CTO of Shopify* Why Shopify is talking more publicly about AI now, and why staying at the frontier has become necessary for the company* Shopify's internal AI adoption curve, the December inflection, and why CLI-style tools are rising faster than traditional IDE-based tools* Why Jensen Huang is directionally right on token budgets, but raw token count is still the wrong way to evaluate engineering output* Why the real unlock is not more agents in parallel, but better critique loops, stronger models, and spending more on review than generation* Why AI coding can still lead to more bugs in production even if models write cleaner code on average than humans* Why Shopify built its own PR review flow, and why Mikhail thinks most off-the-shelf review tools miss the point* How PR volume, test failures, and deployment rollback are becoming the real bottlenecks in the agent era* Why Git, pull requests, and CI/CD may need a new metaphor once code is written at machine speed* What Tangle is, and how Shopify uses it to make ML and data workflows reproducible, collaborative, and production-ready from the start* Why Tangle is different from Airflow, and why content-addressed caching creates network effects across teams* What Tangent is, and how Shopify is using auto-research loops to optimize search, themes, prompt compression, storage, and more* Why Tangent is becoming a democratizing tool for PMs and domain experts, not just ML engineers* Why AutoML finally feels real in the LLM era, and where auto-research still falls short today* Why Tangle, Tangent, and SimGym become much more powerful when combined into one system* What SimGym is, why simulated customers only work if you have real historical behavior, and why Shopify's data gives it a moat* How SimGym evolved from comparing A/B variants to telling merchants what to change on a single live storefront to raise conversions* Why customer simulation is so expensive, from multimodal models to browser farms to serving and distillation costs* How Shopify models merchant and buyer trajectories, runs counterfactuals, and thinks about interventions like discounts, campaigns, and notifications* Why category-level behavior is so different across commerce, and why ideas like Chinese Restaurant Processes are showing up again in practice* Shopify's new UCP and catalog work, including runtime product search, bulk lookups, and identity linking* Why Shopify is using Liquid AI, and why Mikhail sees it as the first genuinely competitive non-transformer architecture he has used in practice* Where Liquid already works inside Shopify today, from low-latency query understanding to large-scale catalog and Sidekick Pulse workloads* Whether Liquid could become frontier-scale with enough compute, and why Shopify remains pragmatic and merit-based about model choice* Who Shopify is hiring right now across ML, data science, and distributed databases* The Sydney story at Bing, why its personality was not an accident, and what Mikhail learned from deliberately shaping AI character early onMikhail Parakhin* LinkedIn: https://www.linkedin.com/in/mikhail-parakhin/* X: https://x.com/MParakhinTimestamps00:00:00 Introduction: Mikhail Parakhin, Microsoft, and Shopify00:01:16 Why Shopify Is Talking More About AI00:02:29 Internal AI Adoption at Shopify and the December Inflection00:06:54 Token Budgets, Jensen Huang, and Why Usage Metrics Can Mislead00:10:55 Why Shopify Built Its Own AI PR Review System00:12:38 AI Coding, More Bugs, and the Real Deployment Bottleneck00:14:11 Why Git, PRs, and CI/CD May Need to Change for Agents00:18:24 Tangle: Shopify's Reproducible ML and Data Workflow Engine00:21:19 Why Tangle Is Different from Airflow00:26:14 Tangent: Auto Research for Optimization and Experimentation00:30:07 How Tangent Democratizes Experimentation Beyond ML Engineers00:33:06 The Limits of Auto Research00:36:36 Why Tangle, Tangent, and SimGym Compound Together00:37:20 SimGym: Simulating Customers with Shopify's Historical Data00:42:47 The Infra Behind SimGym00:46:00 Why SimGym Gets Better with Real Customer History00:47:30 Counterfactuals, HSTU, and Modeling Merchant Trajectories00:51:55 CRPs, Clustering, and Category-Level Customer Behavior00:53:30 UCP, Shopify Catalog, and Identity Linking00:55:07 Liquid AI: Why Shopify Uses Non-Transformer Models00:59:13 Real Shopify Use Cases for Liquid01:03:00 Can Liquid Scale into a Frontier Model?01:09:49 Hiring at Shopify: ML, Data Science, and Databases01:10:43 Sydney at Bing: Personality Shaping and AI Character01:13:32 Closing ThoughtsTranscript[00:00:00] swyx: Okay. We're here in the studio, a remote studio, with Mikhail Parakhin, CTO of Shopify. Welcome.[00:00:08] Mikhail Parakhin: Thank you. Welcome.[00:00:10] swyx: I don't even know if I should introduce you as CTO of Shopify. I feel like you have many identities. Uh, you led sort of the, the Bing ML team, I guess, uh, uh, or ads team. I, I don't know, I don't know, uh, you know, it's, uh, people va-variously refer you as like CEO or, or, uh, I don't know what that, that, that said previous role at Microsoft was.[00:00:29] Mikhail Parakhin: Uh, that was... Yeah, my previous role w- at Microsoft was the-- I actually was the CEO of one of Microsoft's business units, which included, as I, you know, as we discussed, all the things that people like to laugh about, uh, including Windows and Edge and Bing and ads and everything.[00:00:47] swyx: Yeah, yeah. What a, what a, what a wild time.You've obviously, uh, done a lot since you landed at Shopify. Uh, one of the reasons I reached out was because you started promoting more sort of internal tooling, uh, primarily Tangle, but also a lot of people have seen and adopted Tobi's QMD, uh, and obviously, I think, uh, Shopify has always been sort of leading in terms of, uh, engineering.I think more-- it's just more recent that you guys have been more vocal about your sort of AI adoption. Is that, is that true?[00:01:16] Mikhail Parakhin: Well, I think AI tools in general are fairly recent development, uh, and we've-- Shopify, you know, at this stage of its development, we're developing AI in-in-house and other, uh, building tools that use AI and, you know, interfacing with the wider AI community, uh, you know, are on the sort of the, uh, runaway trajectory.So it just did by sort of natural byproduct. We, we talk about it more also. We just, uh, just even yesterday, Andrej Karpathy was famous in tweeting about, oh, are there some, uh, ways, uh, that, that you can organize your agents to store the data and then, uh, look up the data so that you don't have to research or, or lose context every- Yestime. And a little bit tongue in cheek, I tweeted that, “Hey, we've, we've done it much earlier, and we even have different approaches, Tobi and I.” Tobi, of course, is a big fan of QMD, and I'm more of a SQL, SQLite fan. But, uh, yeah, very similar things that we've already done here. The point is, yeah, we're very dynamic, you know, explosively growing company, and we have to be at the forefront of AI adoption, obviously.[00:02:29] swyx: Yeah. Yeah. Um, you, your team kindly prepared some slides actually that we were gonna bring up on to, uh, the screen. I think I can, I can screen share, and then we can kind of go through some of the shocking stats that maybe, maybe put some numbers to what exactly is going on. So here we have, uh- An internal AI tool adoption chart.What are we looking at here? What ?[00:02:54] Mikhail Parakhin: Yeah, this is very interesting statistics. Uh, this is number of daily active workers, you know, think of, uh, DAO, basically the active users of-[00:03:05] swyx: Yeah ...[00:03:05] Mikhail Parakhin: AI tool as a percentage of all the people in the company, right? And then- Yeah ... different AI tools. And, uh, you could see two things here is that one is the green is total.Uh, green is just total. So you could see that it approaches really % by now. It's hard not to do your job now without interacting deeply, at least with one tool. You could see another interesting thing is just as many people commented in December was the phase transition when suddenly models gotten good enough that, that everything took off and started growing.Uh, it, it was many people noticed that the thing is that small improvements accumulated into this big change in Sep- December roughly timeframe.[00:03:52] swyx: Yeah.[00:03:52] Mikhail Parakhin: The other thing I would claim you could see is that, uh, CLI-based tools and tools that don't require you to look at the code becoming more popular, and you could see, yeah, various versions of, uh, Cloud Code and Codex and Pi and internal development tools taking off.Uh, exactly, yeah, uh, and blue is our River, just internal agent for coding, where tools, uh, that require IDEs such as, uh, GitHub, Copilot or Cursor, they're not exactly shrinking, but they're not growing as fast. Like, uh, red, red line is, is the IDE kind of tools. So you could see that they're, they're not experiencing as, as fast of a growth.[00:04:37] swyx: As I understand it, basically, every employee has their choice, right? Of choose whatever tool you use, and then you're just kind of doing a, a daily sur-survey or something.[00:04:47] Mikhail Parakhin: Exactly. And, uh, we- Yeah ... the, the push is to get your job done, you can use any tool, and we effectively fund unlimited tokens for everybody.Uh, we, we do, we do try to control the models that, uh, people use, but from the bottom, not from top. Like we basically say, “Hey, please don't use anything less than Opus four point six.”[00:05:09] swyx: Oh .[00:05:10] Mikhail Parakhin: Some people, some people end up using GPT five point four extra high. Some people use Opus four point six. Um, uh, you know, uh, there are some, uh, there are plus and minuses in going for full one million context window versus not.But, uh, we try to discourage people from using anything less than that.[00:05:28] swyx: Yeah, yeah. Got it, got it. Uh, I mean, uh, that's, you know... The, the next chart here, it really kind of shows the expansion and the sort of December twenty twenty-five inflection, right? That, uh, people are using a lot of tokens. I think it's also really interesting that no one was kind of abusing it in twenty twenty-five.Like it was- Had comparatively, uh, to this year, there was almost no growth. I mean, it's still like, you know, probably, probably gave fifty percent.[00:05:56] Mikhail Parakhin: Yeah. This is just a different scale. It's still exponential- Yeah, yeah ...growth at just a different- ...rate of expansion. Uh, there was inflection point, and Sean, I would claim the, the super interesting part here is that you could see that the distribution becoming more and more skewed.Yes. The top percentiles grow faster. So that means- Yeah ...the people in the top ten percentile, they, their consumption grows faster than seventy-five and so forth. So, uh, the distribution skews more and more towards the highest users, which is... I don't know what it tells me. It's like it feels not ideal, to be honest.Or maybe it's okay. We'll see.[00:06:36] swyx: Why does it feel not ideal? Is, is it because of, um, quantity over quality, or what's the concern?[00:06:42] Mikhail Parakhin: Because take it to the limit. That means, you know, if, if this rate of separation continued- Ah, yes ...a year, there will be one person consuming all the tokens. So it's just, it's kinda strange.[00:06:54] swyx: Yeah, I mean, um, uh, I, I think internal like teaching and all that, uh, will, will help sort of distribute things more widely. But in, in the early days, of course, the people who are sort of more AI-pilled will obviously find more ways to use it than the people who are less AI-pilled. Maybe let's, let's call it that.I'll just, I'll just kinda quickly, uh, pause from the, the... You know, we will go back to the rest of the slides, but I just wanna, um, review, you know, there are a lot of CTOs of, of large companies like yourself where they're all considering some kind of token budget, right? Like I think it's something, something that Jensen Huang has been talking about, where like if your 200K engineer is not using 100K of tokens every year, like they're, they're underutilizing coding agents.Of course, Jensen Huang would say that, but like it seems a very quantity over quality approach and like some, some people are basically saying like, well, is this comparable to judging engineer quality by lines of code, right? Which we also know is like kind of flawed, but better than nothing. So I, I don't know if you have like a sort of management take here on, on how to view this kind of, uh, metrics.[00:08:02] Mikhail Parakhin: Well, I mean, you're, you're baiting me. I, I like... This is my favorite topic. Uh, if you let me, I'll probably talk for two hours on just this. I have a lot of things to say. Like I do think Jensen gotten a lot of bad press saying, “Oh, of course you're, you know, this, uh, the- ...the cake seller says you don't need enough cakes.”You know? Like, of course. Uh, but, uh, I actually, uh, think that's undeserved. I think he, he's actually right. Uh, I do think- He,[00:08:33] swyx: he's directionally correct.[00:08:35] Mikhail Parakhin: Yeah. Yeah. He's directionally correct for sure. Uh-[00:08:37] swyx: Who knows what the right number is? Yeah.[00:08:39] Mikhail Parakhin: The thing that I do Uh, want to say, and this is something that we learned through trial and error and very important is like two things.One is that it's not about just consuming tokens. Uh, you can consume tokens and, and in fact, the anti-pattern is running multiple agents, too many agents in parallel that don't communicate with each other. That's almost useless, uh, compared to just fewer agents and burns tokens very efficiently. Uh, setting up the right critique loop, especially with the high quality models, where one agent does something, the other one, ideally with a different model, critiques it, uh, suggests ways to improve it, the agent redoes it with this critique and, and so it takes much longer.So people don't like it because latency goes up. You know, they, they have to wait until this debate is happening. But, uh, the quality of the code is much higher. And another thing, just since you mentioned like, look, uh, uh, yeah, the overall budget is just like, uh, lines of codes. Lines of codes are exploding for everybody right now, or partially because AI is really mover balls, but partially just because AI can write a lot more code, you know, doesn't get tired.And so you have to have to have a very strong narrow waist during PR review. Otherwise, just the number of bugs will go through the roof. It's, uh, it's this unexpected consequence of the just volume trumping everything. I would claim by now good model writes code on average with fewer bugs than, than the average human.But since they write so much more of it, like more of it will make it into production. So you have to- You still[00:10:26] swyx: have[00:10:26] Mikhail Parakhin: more bugs. Yeah. Have to have a very rigorous PR reviews, also automated of course. But, uh, yeah, that to spend a lot budget there. Like this, this for me, for me, actually, the important metric is the ratio of budget spent during code generation versus, uh, spent, uh, expensive tokens like GPT, uh, five point four Pro or, uh, uh, Deep Think from Gemini, you know, checking on PR reviews.[00:10:55] swyx: Yeah, totally. Uh, I noticed in your chart you didn't have any review tools. Do you just use like, like let's say a Claude code to review tools? Or do you have another set of review tools like the Greptiles, the Code Rabbits, uh, Devin Reviews has a review tool. I don't know if you've had those specialist review tools.[00:11:13] Mikhail Parakhin: You are a little bit jumping on my store tool right now because the graphs I was only showing public tools. Uh, uh, the-- I haven't found a good PR review tool that, that does what I think should be done. And, uh, partially my, my thinking is because it's so... It just goes against both what people feel like emotionally they prefer and, uh, some of the, uh, you know, frankly Even business models that, that the companies run.At peer review tool, uh, time, you want to run the largest models. That means, I don't know, Codex or, or, uh, Cloud Code is not gonna cut it. You need to have pro-level models if you really want to, uh, stand the tide of bots from going into production. And you need us to spend a lot of time, the models taking turns, but you don't want, like, a big swarm of, uh, of, uh, agents.So in fact, you end up in a different dual-dualistic world where you generate not that many tokens. You, in fact, generate few tokens, but it takes f-a long time because these are expensive models taking turns rather than many, many agents trying to do many things in parallel. So that's, that's why I feel like I haven't found good tools, so we are using our own for peer review for now.[00:12:33] swyx: Yeah. Yeah. I mean, uh, I think a lot of companies are building their own, uh, especially to their needs, right?[00:12:38] Mikhail Parakhin: Mm-hmm.[00:12:38] swyx: Um, I, uh, you also have a chart here going back to the slides on, uh, PR merge growth, where we're now at thirty percent, uh, month on month rather than ten percent. Uh, and also the, the estimated complexity is going up.You know, this is productivity, right? ‘Cause y- presumably there's more stuff going into the code base and more, more features getting worked on. I'm curious about the backlog, right? Like the, the, the-- I actually don't mind a pro-level model taking an hour or two hours to review my PR, because I've dealt with humans who take a week to review my PR, right?And I keep pinging them on Slack, “Hey, hey, review my PR.” So, you know, I think there's some trade-off here where, like, it still doesn't make sense.[00:13:18] Mikhail Parakhin: Exactly. That, that's exactly m-my point. Uh, that on one hand, you can tolerate longer latencies at, uh, PR. On the other hand, like right now, the real problem is not in spending time waiting for PR.It's real problem is since there's so much more code than- Yeah ... uh, probability of at least some tests failing going up, and then you, like, keep de-failing, then you have to find the offending PR, evict it, retest it without that PR, and so deployment cycle becomes much longer. Uh, so it actually, in terms of the overall time to deploy, it's total time savings if you spend more time on a longer model, like thinking for an hour, because then, then you, you don't have to spend all that time during testing and rolling, you know, rolling back the deployment.[00:14:03] swyx: Yeah, totally. That's still worth it. You know, you don't look at the individual, look at the aggregate, and look at the, the, the change in the aggregate system.[00:14:11] Mikhail Parakhin: Exactly.[00:14:11] swyx: I'm kind of curious if, like, there's this PR mentality and, like, c-- the, the, the CICD paradigm will be changed eventually. Some people are like, obviously a lot of people want new GitHub, but I even wonder if, like, Git is the problem, right?Like, is that the bottleneck? Is the concept of a PR a bottleneck? Do you guys use stack diffs? I don't know if, uh, that's a, like, a merge queue stack diff type of thing.[00:14:34] Mikhail Parakhin: We, we use, we use Stacks, we u- we use Graphite. We worked with, uh, Graphite a lot. Uh, so we use Stack, uh, PRs. I think, uh, like that's clearly the overall CICD in general, and the interaction with the code repository right now is the, clearly the sort of the, the main issue and the bottleneck for us, uh, and highest top of mind.I would say we probably need a different metaphor or different whole design of how to process it in new agentic world. I haven't seen anything dramatically better yet. I, I think everybody right now is just trying to keep their head above the water ‘cause, ‘cause there, there's so many PRs and then everybody's CICD pipelines start creaking, the, the times are increasing, the number of bugs slipping by increasing, and you have to, have to clap on down.And so we are a little bit in this situation when we need to first stabilize that story and then start thinking, hey, what, what it could be a completely different and new world, which I haven't... I know some people working on it. I haven't seen something, like anything super compelling yet, but clearly the old thing were designed for humans will need to be morphed into something new.[00:15:53] swyx: One of the thing that I, I think about is kind of like the merge conflict is basically a global mutex on the whole system, right? And in, in hu- in human organizations, we do have something like that. It's the company standup. But like, other than that, it's like it's actually fitting for us to be somewhat decentralized, somewhat plugged into one stream of information source, but somewhat lossy.Like it's okay, you know, that, that not every delivery is like atomic consistency. Like we're not dealing with a database sometimes.[00:16:27] Mikhail Parakhin: This is a very good point, uh, because since humans don't write code too fast, you know that global mutex is not too bad. Once you-[00:16:36] swyx: Yes ...[00:16:37] Mikhail Parakhin: start writing code at the speed of machine, it becomes the, you know, the bottleneck.Then what do you do? Maybe, and I can't believe I'm saying this because I, I'm long-- lifelong opponent of, uh, microservices, and I always thought that was, like, a really bad idea. And now that you're saying it, like, maybe in new guys like microservices will make a comeback, you know, because then you, you can ship things independently in tiny things and, and the managing all that complexity automatically will be much easier.I don't know. Like, we'll s-- we'll have to see.[00:17:10] swyx: Yeah. I mean, I don't know what the Microsoft or, or Shopify thing is, but I, I read this paper from Google where they have a monorepo that deploys into microservices, right? And then, uh, the other concept that I think about a lot is the Chaos Monkey concept from, from Netflix.Being able to create, like, this robust system where, um, uh, you know, you, you have the service discovery, you have the, uh, the independent, independent microservices discovery and, and, uh, you know, probably going to be a fair amount of duplication. That's how an organic system sort of scales, uh, that, that you have that...I don't know how you call it. Slack? Robustness? Depend-- uh, d-duplication. I, I, I forget the-- I, I'm-- And this-- those-- these are not exactly the terms- Hmm ... I'm looking for, but I c-can't really think of the words. Okay. I was gonna go into Tangent and Tangle. Uh, so, uh, we, we sort of discussed the overall stats that, uh, Shopify has.Uh, but, you know, I, I think some, some pretty cool stuff that you guys are working on is your ML experimentation, uh, and your, your sort of auto tr-research training pipeline. Presumably you're much closer to this one because it's, it's a sort of personal hobby of yours. How, how would you explain them in, together?I thought we have a slide that, like, uh, has the s- the system diagram.[00:18:24] Mikhail Parakhin: Yeah. Tangle first and then Tangent as a-[00:18:27] swyx: Yeah ...[00:18:28] Mikhail Parakhin: as a thing on top of Tangle. And, uh, Tangle is the third generation, I claim, of, uh, systems of, uh, running any data processing, but a bit with a skew for ML experiments, but not necessarily. Any sort of data processing tasks where you need to iterate, share, and you have scale so that you want maximum efficiency.You know how, like, normally you would work, you would-- Imagine you're a data scientist or an ML practitioner, you would get Jupiter notebooks or, or maybe you would get, uh, you know, Pyth- your Python scripts, and you would manage the data, and you produce those TSV files, and you put them in some JFS or something.Then you would notice that, oh, it has this, uh, weird missing values. You go and write another script that, uh, goes and replaces them with, uh-[00:19:20] swyx: Ah ...[00:19:21] Mikhail Parakhin: dash S. And then, then you, then you run some, some, uh, “Oh, I need to filter bots.” And so you run some light GBM model that, uh, removes the bots. And then, then you like-- And then you, you kind of like get into shape, and then you start experimenting, and you run multiple experiments, and then you're like, “Oh my God,” like, “this experiment is worse.”You undo, and you cannot get to previous result. And like, “Ah, what did I do?” Like that. Again, then, then you finally like get everything working. Then you like start throwing it over the fence to production. You, you replicate it, those things don't work, and then sometimes you like don't notice that you forgot some feature naming and the, the features don't match.But then, like imagine you, you did everything, and then six months later you're like, have to repeat it because now there's more data, or you wanted to do another pass, and you're like, “What, what did I do?” Or like, or like, “This script crashes now,” or the, “the path has changed.” And then, then you're trying to, like you spend another month just doing ar- digital archeology on your own, you know, history, right?Now multiply that by many, many teams. Now imagine you got an intern that you wanna ramp up. Now you have to show that intern, “Oh, you know, look, here's the folder, there's the scripts, you know, ask your cloud agent to do, and then, uh, to, to figure it out.” And then cloud agent does something, and then you're, “Ah, yeah, right, right, it was the wrong folder.I forgot to tell you, I actually have this other thing I forgot myself.” And, and that's, that's the, like, the daily life we all, uh, all know it, uh, if, if you're a data scientist, machine practitioner, ma- machine learning practitioner or, uh, or even like any data managing, uh, person.[00:21:00] swyx: Yeah. So I, I used to do this, uh, f- uh, on the quant finance side, uh, in, in my hedge fund.So we did this before Airflow, and then, uh, obviously Airflow came along and, uh, then more recently Dagster, uh, I would say is like, in my mind, what I would use for that shape of problem, uh, where you had to materialize assets and create a pipeline.[00:21:19] Mikhail Parakhin: And that's, that's very good segue because... So Airflow is great, but Airflow is more about you, you have something and you wanna repeatedly run it in production on schedule.It's less about you as a team developing things and being able to share, and you grabbing the standard pipeline and saying, “Hey, I wanna change this tiny little component in the huge sea of data processing, and I don't wanna-- I wanna run ten experiments on this, and I wanna do hyperparameter optimization.”All that is very hard to do with Airflow. It's very easy to do with Tango. Tango is m- more about, it's everything about group of people Running experiments, it might be agents too nowadays. Uh, running experiments cheaply, collaborating, sharing results. Uh, you don't need to understand fully. You, you grab-- you clone somebody else's experiment or somebody else's pipeline, uh, run, uh, change small piece, run it, be, like, get it to production state, and then ship in one click.So then the... You don't have to port it into any other system to, to run in production. You can just run the same experiment. It's, it's fully production ready. And, and it's, uh, it has lots of... Again, as I said, it's third generation system. The original one was, I would claim there was Ether and then, uh, at least in my career, Ether was the first, first, uh, that pioneered this type of approach.And then there was, uh, Nirvana, which, uh, uh, at Yandex, which did kind of sec-second take on this. And now this one aggregates the, the learnings from all of those and, and Airflow as well to, to get to the state where you try it, it, it feels kind of magical. Uh, ‘cause now everything is based on content, uh, hashes.So even if the version changed, but if the output didn't change, nothing is being rerun. It's very efficient. If you... Multiple people start experiment that needs the same sort of data preprocessing, it's not repeated multiple times. It's automatically done only once. If you start ten experiments that all require, you know, some, some data preparation first as the first step, and you don't have to coordinate for that.Like, you don't have to know that other people are starting it. You now, it's very easy compos-, uh, composability, any language you can u- uh, you wanna use, and it's very visual. So you can see immediately, you can edit it easily, you can assemble small things with just even mouse clicks if you want to, and, uh, share, clone.And everybody knows also it's fully kind of static in the sense that we rerun it second time, it will exactly have the same results. Like, you will never have to do digital archeology. So full versioning and everything is also there.[00:24:06] swyx: Uh, so, so people can, uh... It's open source. Go to the GitHub repo and, and, uh, check it out.Uh, and it is also a really good, uh, blog post about it. I think all these is, like, really appealing. The, the, the, the thing that I think sells me the most about it is that, um, sort of development to production transition, right? Which I think, um, a lot of people haven't really solved that, uh, strictly, right?Like, we develop really, really well in, in Python notebooks, but then, you know, that's obviously not a sort of production ready process. I think that, like, any way in which that is solved, I think is, is very appealing. Then the other thing that you mentioned, which also raised my eyebrows, was content-based caching, which you mentioned is, is, um, you know, is ve-very much, uh, um, a sort of efficiency measure about, uh, you know, just like recalculation only on, on sort of content addressing Which I think makes sense.Uh, it surprised me that the savings could be this much, but maybe I just haven't worked at your scale where there's so much duplication, uh, that people just rerun because they change a single ID upstream.[00:25:10] Mikhail Parakhin: It does, yeah. But it's not only you rerun. The, the main savings are coming from the fact that you ran it, you got your job done, and you moved on.Then- Yeah ... somebody else in some department you don't know existed runs the same task, but on a newer version.[00:25:27] swyx: Yeah.[00:25:27] Mikhail Parakhin: Like right now, you can't, in, in most of the organizations, you can't even find out about it so that you can't even measure that you're spending that time twice, right? Here- Yeah ... if everybody's on Tango, that's detected automatically and detected that the output is the same.And then for that person, all it looks like is like experiment just suddenly moved, jumped forward, right? Uh, uh- Yeah ... so that's because, because the, there's network effect of multiple people helping each other.[00:25:51] swyx: Yeah. This is one of those things where it's designed to be a platform from the beginning rather than an individual developer's tool from the beginning, right?And, and everything's gonna streams down from there. That is the sort of Tango, uh, orchestrator, and it's, it manages jobs. We've seen a few versions of this, and this is obviously, uh, uh, the sort of, uh, unique approaches that you guys have, have, uh, figured out. And then there's Tangent.[00:26:14] Mikhail Parakhin: Yeah. And Tangent is basically an automatic auto research loop that can help and kind of do your work for you.Uh- ... you know, uh, effectively, effectively, Andrej Karpathy recently popularized it with auto research. Yes. Remember he said like he was, uh, speed running this, uh... Yeah, uh, you know the story. The, here we're basically bringing the same capability into Tango so that, uh, the, uh, Tangent can analyze it. It's just an agent that can run multiple experiments, figure out what can be changed, and keep on rerunning it, keep on modifying until, uh, maximizing some goal, some loss function, whatever you need to, to achieve.And in general, I would say if you're not using auto research-like approach in whatever you do, like literally whatever you do, then you're missing out. We saw at Shopify that taking like a wildfire, anything where you can put measurements can be done dramatically better. Our-[00:27:19] swyx: Mm-hmm ...[00:27:20] Mikhail Parakhin: uh, speed of, uh, templatization HTML, uh, completely new UX tem- uh, templatization of, uh, reducing latency for liquid themes.Uh, we-- Our, uh, search, uh, recently we moved from It's hard even, uh, quote from eight hundred QPS to forty-two hundred QPS with the same quality just by pure optimizations and not a research loop that kept running and changing code in our index serve on the same number of machines, just increasing the throughput.We, we managed to improve the quality of gisting and machine learning process. Uh, you know, gisting is the prompt compression technique that[00:27:59] swyx: allows for[00:28:00] Mikhail Parakhin: lower latency and, and lower and, uh, actually higher quality slightly. So like literally whatever different walks of life, and it doesn't have to be AI related.Uh, we, we had a reduction in, uh, storage because the agents would go and find data sets that clearly are derivative, uh, and then you don't need to store things twice. You know, we, we, we found somewhat embarrassingly that it was one of the largest tables was hashing random IDs into another random ID, and we literally- Oofput only one. So it was translating, yeah, two random IDs hashed[00:28:36] swyx: into[00:28:37] Mikhail Parakhin: each. So, so[00:28:37] swyx: it has access to the code as well, so it can, it can check the, like what, what the hell is it doing?[00:28:42] Mikhail Parakhin: So there, there cou- it could be run in two levels. You, uh, you know, at the superficial level, it could just use ex-existing components and, uh, reshuffle them.Uh, you know, like you can grab- Yeah ... uh, XGBoost, and you can grab some, some Py- PyTorch module, and then can grab some, you know, grab another tools and, and combine them. At a deeper level, since Tangle is all sort of CLI based underneath you, every, every component is a wrapped really CLI, uh, call and a YAML file, it can analyze code and create new components and, and, uh, keep on iterating as well.So, so you can, you can both have quick modifications of existing t- uh, pipelines with the, with components that are already there pre-baked, or you can create new components, uh, and-[00:29:29] swyx: Yeah ...[00:29:29] Mikhail Parakhin: keep iterating on those. So auto research is, again, this is probably the, the thing I was excited the most in the last two months happening, and we see it taking like, like totally like a wildfire.Just, uh, everybody, every day, every... well, every day, every minute, I would, uh, have somebody Slack message saying, “Oh, look how much better I made it.” And, uh, it's all throughout the research.[00:29:53] swyx: Is this democratized in some way in, in the sense that like is it your ML, uh, engineers and researchers doing this, or is it your regular PMs and software engineers also have the ability to auto-- to use Tangent?[00:30:07] Mikhail Parakhin: This is an awesome question. Like, Tango in general and Tangent in particular are extremely democratizing. Like they- Yeah ... they are the main tools for- ‘Cause I don't[00:30:15] swyx: need the details.[00:30:16] Mikhail Parakhin: Yeah. Exactly. Initially used by ML and AI engineers, but then literally, as you said, PMs are like the highest user right now is one of PMs on our org, uh, Sartak and he was, he was number one by, by usage of, of this ‘cause they're just, uh, energetic and knowledgeable, and now it, it unlocks a lot of capability where you don't have to co-change code manually.[00:30:39] swyx: I mean, I mean, because it kind of cuts out the ML, ML engineer from the process because the, the, the PMs have the domain knowledge and the ability to think about, uh, from first principles about, okay, what, what results do I want? And they can-- they even have the access to the data that, that needs to go in.So it's like in some ways, like this is the magic black box that we've always wanted for, for training and, and for, uh, I guess, uh, uh, hill climbing, whatever.[00:31:04] Mikhail Parakhin: It's basically cloud code for your AI development- ... uh, situation, right? Like now, now you don't have to know exactly how algorithms work. You can just, uh, bring your domain knowledge and expertise and product knowledge and iterate within Tangent until you've gotten the results that you need.[00:31:21] swyx: In my previous roles, every time that someone has pitched AutoML, you know, I've always been like, “Uh, this is not, this is not gonna work. It's, you know, it's, it's always gonna be a flop.” Somehow it's working now. I mean, presumably the answer is now we have LLMs and it's good enough, right? It's, it's an emergent property that we can do auto research, but like, it doesn't feel that satisfying that how come we didn't do this before, right?Like we just did like parameter search and like, I don't know. That's maybe that's it.[00:31:48] Mikhail Parakhin: Yeah. Bayesian optimization and hyperparameter optimization was, was the one that, or facet of AutoML that was used very actively, which incidentally also built into, uh, Tango. But, you know, I know Patrice Simard very well, and, uh, he was such a, uh, such a proponent of AutoML, and he put, like literally spent careers trying to democratize it.Without LLMs, it just turned out to be very hard. Like it, you, you would have flexibility within certain narrow domain, but it was hard to wider scale, and now with LLMs suddenly it's like magic wand, and so suddenly everybody- ... is an AutoML expert.[00:32:28] swyx: Yeah, I, I think it's multiple things, right? Like I'm, I'm just gonna bring up the, the, the chart again, right?Like LLMs can do the monitoring very well. That is the very potentially unbounded, super unstructured. It can do the analysis very well, it can do the... Uh, and basically it is much more intelligence poured into every single step. Uh, there's maybe nothing structurally changed about AutoML, but this is just m-more intelligent and more unstructured.[00:32:53] Mikhail Parakhin: Exactly.[00:32:54] swyx: Any flaws that you've run into? Like everyone is like drinking the Kool-Aid, oh my God, time savings, uh, you know, performance improvements. Like what, what, uh, issues have you have, uh, come up?[00:33:06] Mikhail Parakhin: This is really cool. It's not a solution to all the world's problems for sure. The limitations are usually the ones I-- And this is where we get into a bit of a subjective territory.Uh, I can only share what I've, I've seen so far, and I'm sure the situation, uh, is changing, and, you know, maybe after I say it, like many people will reach out and say, “Hey, what about this?” And you don't know that, and then, then we'll be probably right. But what I've seen is auto research is very good at doing kind of obvious things that you don't have bandwidth to do or you didn't notice or maybe you're not aware of like the-- some standard practices.It is not good at doing something completely out of distribution, something that, you know, you have to think for, for multiple days, uh, and, and do something like none of this. So, so it's, uh, I, uh, set an experiment once, uh, on, on my sort of, uh, hobby thing, and I let it run for, uh, ended up, uh, several weeks run, uh, you know, it's like full production kind of scale, so it, you know, slow runs and, and it ex-- it performed in the end, uh, over four hundred experiments, and only one was successful.I'm like, “Okay, that's, that's good.” But-[00:34:18] swyx: But it saved time.[00:34:19] Mikhail Parakhin: Yeah, I saved time. Like it, it was the, that thing. Yeah, if I, if I were doing four hundred experiments myself, my betting average, as I said, would have been much higher, I'm sure. But also, first of all, it would take me like three years to do four hundred experiments.And, uh, I didn't have to do them. Like the machines were just, uh, the price of electricity did that. So, and I got one improvement, uh, that in, uh, my, my-- Honestly, when I was starting that experiment, my thinking was to go and show that, “Hey, Andre, maybe you just don't know how to optimize.” And I was super smart because in, in my pro-problem, it was optimized for many years, and it was like fully improved.Uh, and I didn't expect it, you know, auto research to find anything at all. Yet it did. So instead of making fun of Andre, I ended up, uh, a big, big supporter. Yeah, that's exactly the tweet. Yes.[00:35:10] swyx: You and Toby really, really go back and forth on-online a lot, which is really funny. Uh, think of it as, as an eval for the optimalness of the code it's running on.Uh, it's almost like it reminds me of like a Kolmogorov complexity thing, but, uh, I guess it's-- there's some optimal thing that you're trying to sort of reduce down to, I guess. Um, and so, so you, you, you know, you should congratulate yourself that you had, uh, you know, uh, ninety-nine percent, uh, optimality.[00:35:36] Mikhail Parakhin: Exactly, yeah. I think Andre really deserves a lot of credit for popularizing this approach. This is, uh, this is incredibly, I think, powerful and cool and You know, the, uh, even him, him just mentioning it led to a lot of gains in a lot of places in the industry, so we should be thankful.[00:35:56] swyx: Yeah. I think he also has a just...I don't know what it is. Like, um, you know, it, it is a simple self-contained project that people can take and apply to other things, which is, is, is one thing, but also just the name. Just like somehow no one, no one managed to call their thing auto research. It's just naming things is very important. I think that that is mostly, uh, our coverage of Tango and, and, uh, Tangents.I think obviously, you know, there's a lot of, uh, ML infra at, at Shopify that people can, uh, dive into. We're about to go into SimGym, but before I do that, any, any other sort of broader comments around this whole effort? Like where is it, where is it leading to?[00:36:36] Mikhail Parakhin: As a segue to SimGym, like all those things start composing strongly.And, uh, you could see a huge unlock when you can look at each one of the tools and, and you see, oh, they're extremely useful. Uh, Tango is useful by itself. Auto Research is useful by itself. SimGym is useful by itself. If you combine all three, you create like synergetic effect. I think that's why we wanted to even, uh, cover them today is because this is something that if you go back even, you know, five years ago, would've been unthinkable.Uh, replicating that, uh, would, would be either incredibly costly or impossible, right? With probably thousands of people are required.[00:37:20] swyx: Well, we have serverless human, uh, serverless intelligence, right? Like, uh, so yes, you do have thousands of hu-- of, of intelligences, not just, not humans. And that's, that's close enough, right?Even if they're not AGI, they're, they're close enough to do the, the task that you need them to do. And, and, you know, that's, there's plenty for, for a lot of routine work, knowledge work. Okay, let's get into SimGym. Um, this is one of those things I, I was surprised to see actually it's apparently your, uh, one of your most popular launches, and I think something that, uh, I think Sim AI, I think Yunjun Park, who did the Smallville thing, there's a very small cottage industry of people trying to do like the simulate customer thing.I think a lot of people maybe don't super trust this yet because they're like, well, obviously they would just do what you prompt them to do, right? But maybe just think, uh, tell us about the sort of inspiration or origin story.[00:38:10] Mikhail Parakhin: That's exactly actually the thing I wanted to cover, because if you don't have the historical data, all you can do is prompt a-agents in a vacuum, and they will do exactly what you prompt them to do.In fact, when I first proposed it, and this is a bit of, um, my brainchild initially, if I, I can boast, even Toby said like, “But wouldn't they, they just repeat what, what you tell them?” And, uh, but I'm like, “Yes, except Shopify has decades of history of how people made changes and what there is, uh, there, what it resulted in terms of sales.”So now what we can do is we can-- we have this... It's not, it's a noisy data. There's a small, usually websites, uh, you know, like things, things are never in isolation. It's almost never AB experiment. It's always AA experiment when there's has two meanings, but basically, you know, in different time you run two different things.But if you aggregate in general, uh, like everything together, and you apply, uh, denoising and collaborative filtering like approach, you can extract a very clear signal. And then you can optimize your agents. And that's why it took so long. It took almost a year of that optimization of just us sitting and fiddling, and, and we had this internal goals of correlation of hitting-- internal goal was to hit zero point seven correlation with, uh, add to cart events, for example.Like that, that if we run real AB test experiment, that it should, it should go and, and rep-uh, replicate, uh, same sort of success that, that humans had or lack thereof. And it, it took forever, and I don't think that's easily replicatable because, uh, like who else would have that data? You have to have this historic, you know, decades, uh, worth of data.And now, now the, like the other thing you need is in-infrastructure and the scale, right? Because, uh, w- again, what we found, uh, stat sig results, you need to run a lot of simulations, a lot of agents, and, and it's-- Those are expensive things. Like you're, you're making actions in the browser because you want a real friction.You want to, to be able to get the image like of what humans will see because you wanna, uh, detect effects like, “Hey, if I make my images larger, will I have more sales or l- uh, fewer sales?” And like usually people's intuition here, by the way, is that I increase my images, I will have more because they look nicer.You know, designers all look sparse and big images. Like usually your sales tank, right? But, but, uh, you know, from HTML, all the characters look the same only the, the size tag looks different, right? So it's very hard. So you have to take visual information, you have to run this in simulated browser environment on the big farm and, and of course, you have to have, uh, like very, very expensive model, good model with multi-model model.So all this it's-- is what's taken so long and, uh, to share my personal fail a little bit there, Sean, is like, you know, we always had this bias to-- for like large company bias. You know, we always, uh, whenever you-- we do, we're like, “Hey, we'll run an experiment,” right? We make, make a change, and we will run an experiment and then, uh, see, uh, see which one's better or like, “No, this is worse,” and most of them are worse, so you discard it and keep iterating, hill climbing.And we're like, “Oh, like smaller merchants, they cannot get stat sig results. They cannot really run experiments simply because, you know, in a week there would be not enough data for them.” So we thought from this perspective. What we didn't realize is that most people don't have A and B, they just have one thing, and they need suggestions of What A and B should be.So, uh, we first build this, hey, we run simulation on two separate teams and, and, uh, say, “Hey, which one is better?” We then morphed it into, and very recently just released it, when you have just your site, your theme, we run over it and we say, “Hey, here's what predicted values of, of, uh, uh, conversions are, and here's how we think you should modify it to increase your conversions.”And then circling back to what you started with, the proof is in the pudding. Like, if we are not correlating with reality, like, people will not be using it. And, uh, thankfully, we see literally every day more users than the previous day. So, so right now, uh, right now- It's working. Yeah. I'm-- Right now my problem is how to pay for it all because the so our major thing is how to optimize the LLMs, do distillation, how to run the headless browsers, uh, and handful browsers, uh, uh, cheaper so that we can accommodate the increase in traffic.[00:42:47] swyx: Yeah. I, I understand that you, uh, you published a lot of technical detail at GTC, so I was just gonna bring it up a little bit. I think s- was this in, in con-conjunction with some kind of GTC presentation? Or something like that, right?[00:42:59] Mikhail Parakhin: Well, we, yeah, we, we did it in several place, but yeah, we had the engineering- Yeahblog, uh, as well. Yeah.[00:43:05] swyx: Yeah. So you're running, uh, GPT OSS. Uh,[00:43:08] Mikhail Parakhin: the, this is an older version. You know, now we run multimodal model. But yeah- Yeah ... GPT OSS, we still run GPT OSS as well for[00:43:15] swyx: And then you have the VMs, and you also have browser-based. I really like this one where it you said, “It violates almost every assumption that standard LLM serving is designed for.”And then you had like, basically orders of magnitude differences between everything.[00:43:29] Mikhail Parakhin: Exactly. Which is, which, uh, which was, you know, a bit of a challenge to implement, like when, like even simple things. Uh, be- since it violates all the assumptions, for example, multi-instance GPUs, like MIGs don't work as well.But we needed, uh, to get MIG to work because, ‘cause otherwise it's way too expensive. And so we had to deal with the, yeah, with, uh, lots of infrastructure and, and, uh, work with, uh, uh, Fireworks and CentML, uh, you know, to help with optimizations and browser-based, as you mentioned. Yeah, like, takes a village.[00:44:04] swyx: Okay. So there's a lot of like, I guess, experimentation in the infrastructure so far, and you've published more or less what you have here. I guess I'm, I'm less familiar with CentML. I, I don't do, uh, that much work in this, this part of the stack. But why was it the sort of preferred instance platform?[00:44:22] Mikhail Parakhin: There are really three probably top companies. There used to be, uh, uh- Three top companies, uh, at least I was aware of that did, uh, LM optimization. You know, together Fireworks and Santa ML, not necessarily in that order. Santa ML recently got acquired by NVIDIA. Uh, what they did is if you have a model and you want to optimize it to a specific prof-- uh, profile of usage, uh, they would go and do it.And, uh, we work with, with those companies, uh, this was work particularly in with Santa ML and NVIDIA to get them the best possible results out of it. And, and sometimes you, you have to retune depending on, like sometimes you want the maximum throughput, sometimes you want minimal latency, sometimes you want like the cheapest, right?And, yeah, or some combination. And so yeah, these are people who would come and help you.[00:45:14] swyx: I see. I see. Yeah, yeah. I'm familiar with these people for the LLM, you know, autoregressive stack. But the other interesting category of these optimizers is also the diffusion people, whereas like Fel and, you know, uh, Pruna recently has come up a lot as well, which I think is like really underappreciated, uh, at least by myself, because I, I thought, oh, all the workload would be LLMs, but actually there's a lot of diffusion as well.[00:45:38] Mikhail Parakhin: Exactly.[00:45:38] swyx: There's a lot here, so I, I, I... it's, it's, uh, it's, it's, it's hard to cover. But I, I do think like people underappreciate the importance of customer simulation, basically. I think this is something that I'm candidly still getting to terms with. Uh, you know, uh, you also-- your team also like prepared this, like, really nice diagram.Uh, I, I assume this is AI generated.[00:46:00] Mikhail Parakhin: Yeah, it looks-[00:46:01] swyx: Maybe it's not.[00:46:01] Mikhail Parakhin: Yeah, it looks, uh, Gemini-ish. Yeah, but, uh, uh, honestly, I, I don't know where, where the hell they generated. It looks, look, uh, looks like it's, uh, Google. But the interesting part, John, that, that, uh, we haven't covered, but I, I wanted to mention is if your store had previous customers, rather than it's a new store, you're like new merchant just launching things, it helps tremendously in just correlation and forecast.Yeah, we take your previous, uh, customer's behavior, and we create agents that replicate those specific distribution of, of customers that you get, and then we a- we apply those to your changes, and then that, that raised raw, you know, the re-- uh, just correlation with the add to cart events or to-- with conversion or whatever it, it, it may be, uh, quite dramatically.So, uh, replicating humans in general seems like an interesting, cool challenge.[00:46:58] swyx: As a shareholder, I think this is the-- like if people are Shopify shareholders, they should really deeply understand this because this is basically the moat. The, the more you use Shopify, the more it will just automatically improve, right?Like you're, you're doing the job for them.[00:47:13] Mikhail Parakhin: Yeah, that's what we started with. Like, uh- ... uh, otherwise, if you're just a startup, I wouldn't do it if, uh, you know, if it was my startup because Without the data, it, yeah, as, as you said, it's, it's exactly the case that, uh, whatever you say in prompt, that's, that's what the agents will be doing.[00:47:30] swyx: The statistician in me wants to like really satisfy the sort of, um, statistical intuition, I guess. Um, to me it's kind of, uh, the, the word that comes to mind is, um, ergodicity. Uh, so let's say a, a customer takes this path, customer takes this path, customer takes this path, right? Um, the... In my mind, the way I explain it is like, okay, here, here's the ninety-five percentile, here's the five percentile, and here's the median, right?Um, but to me, what SimGym is potentially doing is that it can, uh, modify... It can sort of model the sort of in-between sort of journeys as well, that, that maybe are dependent on the previous states. This may be like a very RL-type conclusion where like basically the summary statistics, if you only did naive AB testing, you only have the, the statistics at, at, at a certain point, and you only judge based on the sort of overall summary statistics.But here you can actually model trajectories. Does that make sense? Or-[00:48:31] Mikhail Parakhin: That makes total sense because like, well, that, that makes even more sense that maybe even you realize bec- because-[00:48:38] swyx: Okay. Please,[00:48:38] Mikhail Parakhin: please. Yes ... we do-- Yeah. The, so internally, uh, we have this system, we talked about it briefly once at NeurIPS.We have a huge HSTU-based system that models the whole companies, uh, and their possible paths. And like- Yeah ... what you are, what you are showing, like actually at any point of time, you can either model the user's behavior or you mo- can also think about, uh, the whole merchant as a company, as the entity that acts in the world.You can model that as well. And then you can do, can do counterfactuals. In your graph, like in your blue graph, uh, if you're... Imagine in the center there, uh, somewhere in the middle, you would have an intervention. I give that person a coupon, or I don't know, I send a personal thank you card, or give a discount in some- somewhere.And then you can, uh, then you can do forward rollouts from that counterfactual. So what would have happened with that intervention or without the intervention? And you can even ch- change where that intervention, uh, in time can happen, right? Like some- where, where in this journey. So we, we do this at the Shopify scale for our merchants, and then if we notice that something that they can be fixing, like there's a strong counterfactual, like we have Shopify policy, they basically get a notification like, “Hey, we think your...something is wrong with your-” I don't know, Canadian sales. Like, uh, it looks like it's misconfigured. Here's what you need to do. Or do you think like, uh, you have to set up this campaign with these parameters? And we do that at the buyer level to literally offer discounts or cashback or, or things to buyers.So this is-- I'm getting very excited. Like this is my sort of area of, uh, interest, I guess, and, and hobby. But being able to m-model something complex as human beings or companies and model counterfactuals on it, where you can have interventions in the future and optimize when to make intervention, what kind inter-- uh, what kind of intervention to make.It's such an unlock that previously was completely impossible. Like the-- it was, it was always dreamed of, but never... Like how would you even simulate it without LLMs or HTUs? I think very, very exciting times.[00:50:59] swyx: I just wanted to, uh, to maybe illustrate this. I, I'm not the best illustrator, but I, I am a conceptual statistics guy.And y-you know, you cannot just do this. Like this is a dimensionality AB test doesn't do, right? Like, uh, because it doesn't have the, the, the change over time, uh, stochastic nature, uh, and it doesn't have the sort of contextual like... Here's all the context to this point. Um, okay, cool. Um, that's SimGym.You're, you're gonna burn a lot of tokens on this thing. But you're, you're one of the, the only scale platforms in the world that can, uh, that can do this across a huge variety of workloads, right? I'm even curious on a sort of human, uh, research level of like, well, do, does retail behave d-differently from like clothing sales?D-does that behave differently from electronic sales? I, I don't know. I don't know what else you guys... The Kardashian shoppers, do they differ from like people who buy, uh, I don't know, cars and, uh, whatever.[00:51:55] Mikhail Parakhin: Well, very different, and different sensitivities and different modes of, uh, shopping and, and different levels of what's important.Now, to-totally, you can do aggregations at, uh, at a store level. You can do aggregations at a different, uh, category level. I don't know if, uh, you know, for our statisticians among us, I couldn't believe, but we-- recently we're looking at it, and we had to bring back, uh, CRPs, you know, Chinese restaurant process.It's a, like, way of aggregating and, like, naturally grow clustering. So across... Specifically to answer questions that, uh, like you were just posing on how, how if, if buyers behave different categories. And I'm like, “I haven't seen CRP since two thousand and one.” It's[00:52:37] swyx: so What? It's so- What is... No, I haven't, I haven't seen this.No. This is not in my training. Uh,[00:52:44] Mikhail Parakhin: but, but yeah, it, uh, uh, it actually, like the, the-- there was a very popular kind of theory, popular neurips HTML circles in early two thousands, uh, kind of nice. And now, now it has practical applications, uh- Yeah ... that we were resurrecting.[00:53:03] swyx: Yeah, amazing. Uh, I, I can see, I can see how this is like a, uh, a fun job for you where you get to apply all these things.Um, yeah, yeah, so super cool. Super cool. So, okay, so, so anyone who, who knows what CRPs are and has always wanted to use them at work, uh, they should, they should definitely join Shopify. Okay, so w-we have a lot and but I, I'm, I'm being mindful of the time. I, I do wanted to, to sort of cover some other things.Um, I-I'll give you a choice, UCP or Liquid?[00:53:30] Mikhail Parakhin: Liquid. I think, I think on UCP, you know, like UCP is very important for us and, and it just we are-- UCP, we have a structured, uh, discussions, and you can read about them, and we have, uh, blog posts, and we have a big release this week, in fact, like with our catalog.Oh,[00:53:46] swyx: okay.[00:53:46] Mikhail Parakhin: Uh, yeah,[00:53:46] swyx: but- Le-I mean, we, we can, we can discuss the, the, the release briefly because we'll release this after the-- after it's already announced so whatever. There's a catalog that you guys are doing?[00:53:55] Mikhail Parakhin: Yeah. So we are, we are- Okay ... we are bringing in capabilities of a whole, uh, Shopify catalog.Basically, you now you can search for products, you can do lookups by specific ID, you can do bulk lookups when you need to bring m-multiple products. You don't need to know in ad-in advance what you're trying to show or to sell or check out. Like, you can now, you can now have this decided at, at runtime, and this big area for investment for us for both non-personalized and personalized searches, trying to provide basically a win-window into whole universe of products that are being sold everywhere in the world.And Shopify is really not exactly, but almost like a super set of any-anything being sold. Now we are bringing it into UCP and, uh, and, uh, identity linking is another big thing for us, uh, so that you, you can use, uh, like Google or whatever, whatever identity you have, uh, they're minimizing friction.[00:54:56] swyx: Yeah. So[00:54:57] Mikhail Parakhin: yeah, big release for us.But Liquid AI of course we never talk about, and the problem might be more, more aligned with what we d-discussed previously on this chat.[00:55:07] swyx: Sure. The main thing that everyone understands about Liquid is that it is inspired by Worm, and I still don't know why. I'm curious on your explanation. I think you, you, uh, you can make things very approachable.And also I think like what is the potential of like the, the level of efficiency that you get out of Liquid?[00:55:23] Mikhail Parakhin: You- we all familiar with transformer architectures. And, uh, for the longest time, there was a competing architecture, it's called the state space models. So, so Sams, uh, you know, Chris, Chris Reyes, one of the pioneers and, and lots of startups, uh, trying to make those realities.They have, uh, significant benefits being main being, uh, being much faster and, uh, lower footprint and not quadratic in length, you know, sort of, uh, linear in, in, uh, in your context length. But with state space models- They never quite made it. Like they're used-- They have, uh, certain niches when they thrive, their hybrid architectures are useful, but they never quite made it.And liquid neural networks are, you can think of them as a next step, like, uh, sort of, uh, state-space model square. It's non-transformer architecture that's more complicated than sta-state space and really difficult to code if you-- if I'm being honest. But it's, um, very efficient. It's, uh, subline-- sub, uh, quadratic in, in length of your context.Uh, it's very compact way to represent things, and that's a liquid AI company. They... Their goal is to productize it, and very often you have this need, uh, when you need to have long context and small model, and you want to have low latency. Like in general, it's basically on par with transformers, and if you do hybrids with transformers, it's, it's even better.That's why we at Shopify, when we tried multiple and we constantly try multiple models, multiple companies, we found that for small, particularly with low latency applications, when you have low latency and/or if you need longer context lengths, liquid was the best. And so we still use the whole zoo and always like obviously test and use everything, uh, every open source model and, you know, it feels l

Scott Stipetich, Senior Precision Ag and Conservation Specialist for Pheasants Forever in Wisconsin, joins Tyler and Matt to unpack how yield and profitability data are reshaping habitat conservation on working farms. We dig into identifying marginal cropland, converting unprofitable acres into prairie strips, pollinator plantings, and wetland restoration, and why wider habitat corridors mean better nesting success against fox, skunk, and coyote predation. A must-listen for upland hunters, landowners, farmers, and anyone interested in pheasant habitat, CRP, and practical farm conservation in the Upper Midwest. If you are looking for more information on the topics in this episode, check out these links: Pheasants Forever - Find A Biologist Precision Ag & Conservation in Wisconsin Story Map Precision Ag & Conservation in Wisconsin Minidocumentary Check out the following links for even more content: Instagram Facebook Youtube More About the Upduck Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

What REALLY happens when you take a GLP-1 drug?Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety.This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety update and recent Alzheimer's and Parkinson's research for adults considering, taking, or tapering off a GLP-1.Join Eat More Lift Heavy, the 26-week coached program where adults over 40 build the nutrition and training skills to preserve muscle, lose fat, and manage their physique for life.Timestamps:0:00 - The GLP-1 drug narratives 5:55 - Lean mass loss in STEP 1 and SURMOUNT-1 8:30 - Organ mass, muscle quality, and DXA 10:15 - STEP UP trial and higher-dose semaglutide 11:23 - Cardiovascular outcomes from SELECT and SURPASS-CVOT 13:00 - Inflammation markers and CRP reduction 14:00 - GLP-1s and neurodegeneration research 15:32 - Habits that outlast the drug 17:00 - What happens to your weight when you stop 19:30 - Exercise while taking GLP-1s and natural production 20:48 - 5-part framework for muscle preservation 26:55 - Safety signals and long-term effects 28:12 - 3 high-protein meals when you don't have an appetite

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-481 Overview: Expand your prevention toolkit with new recommendations for cardiovascular disease screening. Listen in as we discuss how high-sensitivity C-reactive protein (hs-CRP) can guide screening for ongoing inflammation in patients who are at risk, the evidence behind primary and secondary prevention applications, and key limitations to keep in mind when applying these recommendations in practice. Episode resource links: Mensah GA, Arnold N, Prabhu SD, Ridker PM, Welty FK. Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology. J Am Coll Cardiol.  Guest: Alan M. Ehrlich, MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Stress Is Quietly Wrecking Your MetabolismWhy Overstimulation Is Sabotaging Your Fat Loss, Hormones, and EnergyThe Thrive Forever Fit Show with Jay NixonYou are not just stressed.You are overstimulated.And your nervous system was never designed for the world you're living in right now.In this episode, Jay breaks down one of the most overlooked drivers of stalled fat loss, hormone disruption, poor sleep, and frustrating lab results: chronic stress from modern overstimulation.This is not about politics.This is not about sides.This is about biology.Your brain cannot tell the difference between a real physical threat and a screen-based emotional trigger.Your body responds the same way.Your nervous system was built for short bursts of stress.A predator.A survival event.A temporary threat.Stress would spike.Cortisol would rise.Adrenaline would increase.Then it would shut off.That was healthy stress.What we live in now is constant stimulation.Notifications.Breaking news.Social media comparison.Emails at night.Financial headlines.Endless scrolling.Your brain never powers down.And when your brain never powers down, your metabolism never feels safe.When stress is constant:• Cortisol stays elevated• Blood sugar stays elevated• Insulin stays elevated• Inflammation rises• Sleep quality drops• Thyroid output can slow• Sex hormones can downshiftAnd then you ask:“Why can't I lose weight?”Because your body does not prioritize fat loss when it feels unsafe.It prioritizes survival.Threatened bodies store energy.Even if you are physically sitting still, high-intensity content activates your nervous system.Heart rate shifts.Stress hormones rise.Inflammatory pathways activate.Stack that multiple times per day, over months and years, and you create a body that is constantly bracing.Braced bodies:• Don't recover well• Don't burn efficiently• Crave quick energy• Struggle to sleep deeplyAnd then we blame food.Chronic stress can influence:• Fasting glucose• Triglycerides• HDL• Abdominal fat storage• Thyroid conversion• Progesterone and testosterone levels• CRP and inflammatory markersYou can eat perfectly and still stall if stress remains high.That is how powerful this is.If your nervous system does not feel safe, your metabolism will not feel efficient.This is why some people see massive improvements simply by improving sleep, reducing stress exposure, or creating more recovery.The body finally receives the signal that it is safe.You cannot control the world.But you can control what you repeatedly allow into your nervous system.You are not just what you eat.You are what you repeatedly consume mentally and emotionally.Your metabolism listens to all of it.In this episode, Jay explains why you cannot out-eat or out-train chronic stress, and why true metabolic health requires nervous system regulation, not just calorie control.If you've been tired but wired, waking at 3am, craving sugar at night, or plateaued despite effort, this episode will change how you see stress forever.Because once you understand this, you stop chasing food solutions for stress-driven problems.And that's where real metabolic mastery begins.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-481 Overview: Expand your prevention toolkit with new recommendations for cardiovascular disease screening. Listen in as we discuss how high-sensitivity C-reactive protein (hs-CRP) can guide screening for ongoing inflammation in patients who are at risk, the evidence behind primary and secondary prevention applications, and key limitations to keep in mind when applying these recommendations in practice. Episode resource links: Mensah GA, Arnold N, Prabhu SD, Ridker PM, Welty FK. Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement: A Report of the American College of Cardiology. J Am Coll Cardiol.  Guest: Alan M. Ehrlich, MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Aaron Kuehl is the National Director of Habitat Programs for Pheasants Forever & Quail Forever. On this episode, Aaron reveals the launch of PF & QF's new online “Habitat University” which offers FREE in-depth online course information about habitat management and how to maximize your efforts in all landscapes. Topics dive into everything about CRP, state specific habitat guides, fire management and tools, building wildlife cover with livestock, eliminating invasive species, safe & effective weed control, tools of the habitat trade, site prep secrets for success, pollinator series, quail by regions, power in partnerships, working lands for wildlife, food plots vs habitat plots, and so much more. @pheasantsforever | @quailforeverPresented by: Walton's (waltons.com/), OnX Maps (onxmaps.com/), GAIM Hunting & Shooting Simulator (https://alnk.to/74wKReb), Black Gold Explorer Dog Food (blackgoldpet.com/), Hunt Fish SD (huntfishsd.com/), Aberdeen SD (aberdeensd.com/), RuffLand Kennels (rufflandkennels.com/), Minnesota Horse and Hunt Club (horseandhunt.com/), & Hoksey Native Seeds (https://hokseynativeseeds.com)See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

We break down recovery as the real driver of strength and health, then show how chronic inflammation can quietly block progress even when training looks consistent. We connect daily signals like fatigue and resting heart rate with blood work markers so you can stop guessing and start adjusting with context. • recovery as returning to a physiological baseline across nervous system, hormones, and immune regulation • signs of poor recovery like persistent fatigue, sleep disturbances, stalled performance, elevated resting heart rate • systemic inflammation basics and why chronic inflammation harms tissue repair, hormone signalling, mitochondrial function • blood work markers to discuss with your doctor including CRP, ferritin, SHBG, free testosterone, fasting glucose, liver enzymes, vitamin D, cortisol rhythms • why free testosterone can matter more than total testosterone for performance and wellbeing • how often to test blood work and why baselines in younger years can change interpretation later • sleep as the highest priority recovery tool over cold plunges and saunas • anti-inflammatory nutrition basics including omega-3s, berries, olive oil, whole foods, less ultra-processed food and sugar • training balance with deload weeks and the principle that better is better than more • stress management tools like walks outdoors, breathwork, and optional meditation • gut health as an immune regulator and why testing beats self-diagnosing supplements • using a feedback loop with training logs, blood work, and one change at a time Check the show notes. You can email me. I will share. I have a doctor, Dr. Omar Ashtar, who is in North Austin, but we everything is virtual, so you don't have to as long as you live in Texas, you can work with him. Email:  bgbryan@gmail.comWebsite:  http://bartonguybryan.comInstagram: https://www.instagram.com/bartonguybryanYoutube: https://www.youtube.com/@mindsetforgechannelMy 3 Top Episodes of the first 100: 7 Essentials to Building Muscle after 40 3x Olympic Gold Medalist Brendan Hansen MMA Strength and Conditioning Coach Phil Daru 

A comment on Medicare coverage of the hs-CRP blood testAre butyrate supplements beneficial to take?Is iron overload a risk factor for heart attack?Nattokinase lowered my blood pressure!Is there a danger of clot relocation when taking systemic enzymes?

Normal blood levels don't always mean you're healthy. Discover why standard lab tests can miss disease, the difference between optimal vs. normal lab ranges, and how to interpret normal lab results when you still have symptoms.Download Dr. Berg's Free Daily Health Routine: https://drbrg.co/45qtO07Normal blood levels are often determined by averages in the population, not necessarily by what's healthy or optimal. Some people suffer from hidden health problems in silence because blood tests often miss disease.You can have high insulin levels for many years before noticing an increase in blood glucose levels. An A1C test assesses blood sugar, but a fasting insulin test is a better indicator of health. A low-carb diet and intermittent fasting can correct insulin resistance and high blood sugar. If you have potassium or magnesium deficiency symptoms, yet your blood levels are normal, it's because the problem is deep in your tissues. Blood tests are not the best way to test for many hidden nutrient deficiencies.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Audrey: Hi Dr. Cabral, What are your thoughts on retained reflexes? My almost 3 yr old girl has extreme outbursts every day that involves lots of screaming and yelling. I was told retained reflexes could be the problem. She is extremely smart and started talking at a very young age. I know she is too young for any heavy metal detoxes or parasite cleanses so I'm not sure how to help her. I also have a 4 yr old and a NB so having some peace in the home would be nice. Thanks      Cathy: Dear Dr Cabral, I'm so thankful for you! In the past 1.5yrs I've lost 30lbs and still losing more. Approx 160lb. 5'5" 64yo female. paleo diet. No gluten, dairy, grains or refined sugar. Very few deviations. I walk/hike 4-5x wk. Recently added strength. Hashimotos- currently NP Thyroid med 30mg.Taking med for 3 mo. Chol. is higher than ever 320. Triglycerides 143 HDL 57 LDL 236 ApoB 157 HDL-P total-29.3 Small LDL-P - 846 LDL size 21.5 CRP- 1.31 Iron runs high 163. I do not have hemochromatosis. TSH- 3.62 Reverse T3-12.5 Thyr perox- 65 Gut testing: Enterococcus spp- 4.60e8 Akkermansia muc -0 Bacteroidetes- 4.97e11 Firmicutes- 1.15e10 Bacciklus spp- 4.31e6 Enterococcus faecium- 4.35e5 Klebsiella spp- 1.35e5 Klebsiella pneumoniae- 3.45e5 Beyond thankful for any insight! God bless you!      Anonymous: Hi Dr. C — Big thanks to you and your amazing team for all you do. Question about purchasing pre-owned items: Are there any health concerns about buying used clothing items or bedding (sheets)? I always wash them before using them. Some people are grossed out about "used bedding," but it seems to be the same as going to a hotel: those aren't new sheets on hotel beds. Thanks.                                                               Sarah: Hello doc! I saw somebody say that red dots (cherry angiomas) on the body can be due to poor bile flow. Curious on your take on this? Cheers!      Basak: I had a quick question I wanted to ask. I divide my time between the Netherlands and Miami, and I maintain the same healthy habits in both locations—clean eating, daily exercise, minimal alcohol, and consistent sleep. I generally feel well and have no other complaints. However, I have noticed that whenever I return to Miami, I consistently experience lower abdominal bloating. I was wondering whether it is possible that environmental factors—such as differences in air quality, water, or other environmental exposures in the U.S.—could be contributing to this reaction. I would appreciate your perspective    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3698 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!