Podcasts about crp

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Audrey: Hi Dr. Cabral, What are your thoughts on retained reflexes? My almost 3 yr old girl has extreme outbursts every day that involves lots of screaming and yelling. I was told retained reflexes could be the problem. She is extremely smart and started talking at a very young age. I know she is too young for any heavy metal detoxes or parasite cleanses so I'm not sure how to help her. I also have a 4 yr old and a NB so having some peace in the home would be nice. Thanks      Cathy: Dear Dr Cabral, I'm so thankful for you! In the past 1.5yrs I've lost 30lbs and still losing more. Approx 160lb. 5'5" 64yo female. paleo diet. No gluten, dairy, grains or refined sugar. Very few deviations. I walk/hike 4-5x wk. Recently added strength. Hashimotos- currently NP Thyroid med 30mg.Taking med for 3 mo. Chol. is higher than ever 320. Triglycerides 143 HDL 57 LDL 236 ApoB 157 HDL-P total-29.3 Small LDL-P - 846 LDL size 21.5 CRP- 1.31 Iron runs high 163. I do not have hemochromatosis. TSH- 3.62 Reverse T3-12.5 Thyr perox- 65 Gut testing: Enterococcus spp- 4.60e8 Akkermansia muc -0 Bacteroidetes- 4.97e11 Firmicutes- 1.15e10 Bacciklus spp- 4.31e6 Enterococcus faecium- 4.35e5 Klebsiella spp- 1.35e5 Klebsiella pneumoniae- 3.45e5 Beyond thankful for any insight! God bless you!      Anonymous: Hi Dr. C — Big thanks to you and your amazing team for all you do. Question about purchasing pre-owned items: Are there any health concerns about buying used clothing items or bedding (sheets)? I always wash them before using them. Some people are grossed out about "used bedding," but it seems to be the same as going to a hotel: those aren't new sheets on hotel beds. Thanks.                                                               Sarah: Hello doc! I saw somebody say that red dots (cherry angiomas) on the body can be due to poor bile flow. Curious on your take on this? Cheers!      Basak: I had a quick question I wanted to ask. I divide my time between the Netherlands and Miami, and I maintain the same healthy habits in both locations—clean eating, daily exercise, minimal alcohol, and consistent sleep. I generally feel well and have no other complaints. However, I have noticed that whenever I return to Miami, I consistently experience lower abdominal bloating. I was wondering whether it is possible that environmental factors—such as differences in air quality, water, or other environmental exposures in the U.S.—could be contributing to this reaction. I would appreciate your perspective    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3698 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Welcome to the land podcast, a platform for people looking to educate themselves in the world of land ownership, land investing, staying up to date with current land trends in the Midwest, and hearing from industry experts and professionals.  On today's episode, we are back in the studio talking with Buck Land Funding.  We discuss: Recreational hunting land has evolved into a legitimate and growing asset class. Interest rates and the broader economy heavily influence land buyer demand. Many buyers upgrade farms every few years as stepping stones to larger tracts. Pre-approval dramatically improves a buyer's ability to secure competitive land deals. Consumer debt like truck payments can drastically reduce land buying power. Recreational land values have steadily risen alongside inflation long-term. CRP conversions can turn lower-quality farmland into strong wildlife habitat. COVID accelerated demand as people sought outdoor recreation and privacy. Many land purchases are emotional decisions tied to family memories. And so much more! Get Pre-Approved to Purchase a farm with Buck Land Funding: https://www.firstbankers.com/bucklandfunding ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.whitetailmasteracademy.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Use code '⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠HOFER' to save 10% off at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.theprairiefarm.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Massive potential tax savings: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ASMLABS.Net⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -Moultrie: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/moultrie_⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -Hawke Optics: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/hawkeoptics_⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -OnX: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/onX_Hunt⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -Painted Arrow: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/PaintedArrow⁠

Get Dr. Vonda's latest insights on strength, bone health, longevity, and aging with power delivered straight to your inbox. Join her free health & longevity newsletter here: https://www.drvondawright.com/resources/aging-longevity   You only build bone during deep sleep, and only if you get enough of a growth hormone spike to make it happen. As someone who has spent her career fighting osteoporosis, I had never connected those dots that clearly before. Morning light, deep sleep, and bone density are part of the same biological chain. That alone is worth the listen. This week, I am joined by Dr. John La Puma, the originator of culinary medicine. After reviewing over 2,200 studies for his new book, Indoor Epidemic, his conclusion is both sobering and actionable: we are spending 93% of our lives indoors, and our biology is paying for it in ways most of us cannot even perceive. Fatigue. Brain fog. Disrupted sleep. Accelerated aging. And we keep reaching for supplements and prescriptions when the answer is often just outside the door. What we cover: - Why 93% of our time indoors is a biological emergency quietly aging us faster from the inside out. - How 10 to 15 minutes of morning light resets your circadian clock and primes your body for deep, restorative sleep. - Why screen light within 30 minutes of bedtime drops melatonin by 20%, no matter what else you did right. - How deep sleep triggers the growth hormone spike your body needs to build bone, making it a frontline tool against osteoporosis. - Why green exercise feels 20% easier and drops cortisol by 21% when done in a place of your choice. - What digital obesity really means and why too many pixels burn out your brain the same way too much sugar burns out your metabolism. - How one hour of gardening a week can lower hemoglobin A1C by 0.5%, roughly equal to a starting dose of metformin. - What the Louisville Green Heart Study found, including a 22% drop in CRP, when greenery came to a community. - Why two to five intentional hours outdoors each week can give you up to five years of health span back.   About Dr. John La Puma: Dr. John La Puma is an academic clinician, trained chef, and organic farmer recognized as the originator of culinary medicine. He runs a certified organic educational farm in Santa Barbara and led the first CME course in the country teaching physicians to use nature as medicine. Indoor Epidemic is his distillation of 2,200 studies into a practical guide for reclaiming your biology. Connect with Dr. John La Puma: Website: https://www.drjohnlapuma.com/ Instagram: https://www.instagram.com/johnlapuma/   Timestamps 00:00 Intro 01:30 Culinary Medicine, Organic Farming and the Origin of a Field 03:30 The Indoor Epidemic: Why 93% Indoors Is a Biological Emergency 07:00 How 10 to 15 Minutes Resets Your Entire Biology 11:00 Screens, Melatonin and the 30-Minute Rule Before Bed 13:30 How Your Brain Cleans Itself During Deep Sleep 17:00 Why Over 50% of Your Genes Run on a Body Clock 20:00 20% Less Effort and a 19% Reduction in Mortality 24:00 Digital Obesity and What Ultra-Processed Time Is Doing to Your Brain 28:00 Indoor Air, Toxins, Carbon Dioxide and the Invisible Cognitive Drain 32:00 Chronic Inflammation, Telomere Shortening and Premature Aging 34:00 Greenery, CRP and Cardiovascular Health 38:30 Gardening, Hemoglobin A1C and the Metformin Comparison 41:00 Deep Sleep and Bone Building 44:30 The Biggest Barrier to Change and Why Knowledge Comes First 46:30 Two to Five Hours Outdoors a Week Can Add Five Years to Your Health Span  

What if everything your doctor told you about cholesterol is based on corrupted science? In this episode of the Gut Check Project, Dr. Kenneth Brown and Eric Rieger dive deep into the emerging world of Lean Mass Hyper Responders (LMHR) - metabolically healthy people on ketogenic and carnivore diets whose LDL numbers look alarming on paper but may tell a completely different story in real life.They break down a groundbreaking citizen-science study led by Dave Feldman and Dr. Nick Noritz that's challenging decades of lipid orthodoxy, explore why high LDL + high HDL + low triglycerides may not be the death sentence mainstream medicine makes it out to be, and share the story of a 53-year-old marathon runner with "normal" cholesterol who still ended up in the cath lab.If you or someone you love has been told to go on statins, this episode is required listening.Topics covered:The LMHR phenotype and what it means for keto/carnivore dietersWhy Ansel Keys and the sugar industry shaped a generation of bad dietary advicePlaque progression, inflammatory markers (hs-CRP), and what actually predicts heart diseaseWhy the Clearly AI cardiac scan study raised more questions than answersThe difference between dangerous cholesterol and protective cholesterol

„Ein Maßband ist hilfreich!“ Dr. Frank Dressler objektiviert damit schnell und einfach Gelenkschwellungen. Der Leiter der kinderrheumatologischen Ambulanz an der MHH hat praktische Tipps und gibt wichtige klinische Hinweise, wie Gelenkbeschwerden rasch eingeordnet werden können. Fieber, Schmerzen, Rötung, Ausschlag: harmlos oder weiter abklären? Bei reinen Arthralgien sind Bildgebung und aufwändige Diagnostik meist verzichtbar, bitte keine ANAs bestimmen! Steht eine Arthritis im Raum, sollten Blutbild, Transaminase-, Leber- und Nierenwerte sowie CRP besser vorliegen. Rheumafaktoren bei Kindern unter 9 machen dagegen keinen Sinn. Genauso wenig, „jeden, der durch die Tür kommt, mit einer Borrelien-Serologie zu versehen.“ Eingängig definiert der Experte klassische Konstellationen: der Zehnjährige mit schmerzender Achillessehne, das kleine Mädchen mit Oligoarthritis (frühzeitige Augenuntersuchung!), Hüftschnupfen usw. Beruhigend: Die Therapiemöglichkeiten sind zahlreich und mit Biologika als Gamechanger ist heute zum Glück der Rollstuhl für Kinder mit Rheuma passé. **Muster anfordern:** Eine Musteranforderung des genannten Produktes ist für Ärzte jeweils in einem Zeitraum von 8 Wochen ab dem ersten Erscheinungstag der Podcastfolge möglich: https://www.infectopharm.de/ma/musteranforderung-devit-weichgummis-podcast/ Weitere Informationen zu DeVit soft Weichgummis Pflichttext DeVit soft Weichgummis Hören Sie auch in unsere consilium Podcast-Folgen zum Thema Vitamin D hinein: Folge 51: „Vitamin D – extraskelettale Effekte“ mit Prof. Dr. Corinna Grasemann (https://consilium.podigee.io/51-new-episode) Folge 16: „Vitamin D“ mit Prof. Dr. Corinna Grasemann (https://consilium.podigee.io/16-16-mit-prof-dr-corinna-grasemann-vitamin-d) **Link zum Transkript:** https://www.infectopharm.de/consilium/podcast/podcast-paediatrie/ **Kontakte:** Feedback zum Podcast? podcast@infectopharm.com Homepage zum Podcast: www.infectopharm.de/consilium/podcast/ Für Fachkreise: www.wissenwirkt.com und App „Wissen wirkt.“ für Android und iOS Homepage InfectoPharm: www.infectopharm.de **Disclaimer:** Der _consilium_ – Pädiatrie-Podcast dient der neutralen medizinischen Information und Fortbildung für Ärzte. Für die Inhalte sind der Moderator und die Gäste verantwortlich, sie unterliegen dem wissenschaftlichen Wandel des Faches. Änderungen sind vorbehalten. **Impressum:** _consilium_ ist eine Marke von InfectoPharm Arzneimittel und Consilium GmbH Von-Humboldt-Str. 1 64646 Heppenheim Tel.: 06252 957000 Fax: 06252 958844 E-Mail: kontakt@infectopharm.com Geschäftsführer: Philipp Zöller (Vors.), Michael Gilster, Dr. Markus Rudolph, Dr. Aldo Ammendola Registergericht: Darmstadt – HRB 24623 USt.-IdNr.: DE 172949642 Verantwortlich für den Inhalt: Dr. Markus Rudolph

Andy Cumpstey is joined by Christian Macutkiewicz Consultant General, HPB and Hernia Surgeon at Manchester Royal Infirmary, Director of The Gallstone Clinic and Manchester Hernia at Spire Manchester Hospital and the incoming President of the Association of Surgeons of Great Britain and Ireland, and Dimitris Damaskos Consultant General Surgeon within the Department of Surgery at the Royal Infirmary of Edinburgh (NHS Lothian), Honorary Clinical Senior Lecturer at the University of Edinburgh. They discuss the postoperative period as a critical part of the perioperative journey, emphasizing the importance of clear postoperative communication, reassurance even after "successful" operations, and explaining complications and expected recovery timelines. They highlight challenges in recognizing deterioration, including reduced reliance on clinical examination skills among junior doctors and the systems-based concept of "failure to rescue," arguing that consistent ward-based recognition systems and high-volume units help detect complications earlier. Enhanced Recovery After Surgery (ERAS) pathways are cited, including using day-3 CRP thresholds to trigger CT imaging for early detection of anastomotic leak. They note post-COVID pressures to clear surgical backlogs have increased situations where patients are operated on by surgeons who did not initially see them, potentially weakening trust and continuity when complications occur, and they discuss flattening hierarchy so trainees can do ward rounds with consultant support. The conversation covers future technology, including AI for risk stratification and imaging interpretation, and remote continuous vital-sign monitoring, while acknowledging data governance challenges and potential deskilling. The episode closes with a discussion of robotic surgery: improved optics and precision and usefulness for more complex cases (including abdominal wall reconstruction), but with concerns about cost, rollout, training implications, and differing adoption between the UK, US, and New Zealand. -- Join us at Evidence Based Perioperative Medicine (EBPOM) World Congress 2026 in London. Be part of a global conversation as clinicians from around the world gather between 7-9th July at the British Library in London. Three days of evidence-based perioperative medicine, global insights, and expert debate—featuring speakers including Michael Marmot and Ken Rockwood. Register here - https://ebpom.org/product/ebpom-world-congress-2026/

Peter Giddings of the Offshore Wind Growth Partnership joins to discuss the UK’s industrial growth plan for offshore wind, the five priority supply chain areas being targeted, and how OWGP helps businesses scale from small suppliers into globally competitive manufacturers. Sign up now for Uptime Tech News, our weekly newsletter on all things wind technology. This episode is sponsored by Weather Guard Lightning Tech. Learn more about Weather Guard’s StrikeTape Wind Turbine LPS retrofit. Follow the show on YouTube, Linkedin and visit Weather Guard on the web. And subscribe to Rosemary’s “Engineering with Rosie” YouTube channel here. Have a question we can answer on the show? Email us! Welcome to Uptime Spotlight, shining Light on Wind. Energy’s brightest innovators. This is the Progress Powering Tomorrow. Allen Hall: Peter, welcome to the program.  Peter Giddings: Thanks for having me out.  Allen Hall: The UK right now is just a global leader in offshore wind, which I think a, a lot of us in the United States don’t even realize that, but the UK is a. Giant leader in offshore wind. Uh, but we keep hearing about the supply chain constraints that are threatening some of the timelines here. What are some of the fundamental problems that the UK offshore wind supply chain has today?  Peter Giddings: We are in a great situation for supply chain, but the 2000 companies, some of them with 25 years experience. At the scale where we can deliver the four gigawatts a year for the next five years that we need to hit our 2030 deployment targets and to keep that deployment rolling. So we are [00:01:00] brilliant at the UK of planning, developing and deploying wind farms. We have a really strong maintenance base. We do some great supply chain work, and IWGP Offshore Wind Growth Partnership has helped those businesses grow, but we don’t have as much capacity as we would like. For the major items. So we have a great set of facilities making blades. We have good facilities, uh, great facilities in JDR making cables, but we don’t capture as much of the manufacturing value of our deployment as we would like. That means we create fewer jobs, we create less economic benefit, and those developers are exposed to more supply chain risk. Specifically, we want to build globally competitive supply chain capacity. We, we we’re, we’re not a charity. We are building businesses that can win contracts. They are attractive to the procurement teams and they’re sustainable, they grow, right? Competitive capacity is what we’re after. Um, and that’s, that’s really what [00:02:00] we’re after. Allen Hall: And if the UK doesn’t really address these problems now, what does that look like for the supply chain? Because you’re talking about moving from roughly 16. Gigawatts in the water to approximately 50 gigawatts, 45, 50 gigawatts by 2030 and beyond. So that’s, you know, it’s roughly a tripling of the amount of capacity in the water supply chain becomes then really critical to that and in order to feed that. But what happens here, if the supply chain has not grown locally,  Peter Giddings: it’s a missed opportunity. I mean, the businesses that are here today would be an incremental growth. And that’s not bad. That’s an okay outcome. But if your deployment is a huge opportunity and you get an okay outcome, that’s not acceptable. That’s not a way to run an industry, right? We have this massive opportunity in front of us. There’s a huge amount that we could do that the UK is great at that the opportunity is to stretch [00:03:00] and help communities all around the coast have. Hundreds, thousands of jobs that are there. They’re stable, they’re good quality, and they are prosperous. It’s a real community initiative. Those towns, which are probably seeing a decline in oil and gas revenue or are strapped to tourism or kind of don’t have an industry, those towns, those people as humans are gonna have a much better future. There’s a, actually a really nice exemplar, um, it’s not. The biggest component, but Cable protection Systems is something that the UK is already globally renowned for. If you open up a tender pack, if you’re allowed to in other markets kind of anywhere, and you look to the CPS package, you would more than likely see a couple of, if not all four of CRP techmark, sub C and Balmoral, right? They, they serve the UK market real well, but they are globally renowned. [00:04:00]That’s, that’s one example. We are looking to do that for the priority sections of the industrial growth plan. You know, we’re going to pick and are picking the areas of the supply chain where we think the UK can be genuinely competitive and we have something to offer. A developer is not gonna choose a substandard product that’s a bit more expensive, but we can build up supply chains that offer fantastic products. Cable protection systems, and we can capture big market share there. Develop a product that can be exported, or if it’s a bit too far to ship, develop a business which can open up a new base. You know, so we, we get that, um, combination of local demand being served. And when I say local, I mean like the North Sea in Baltic and that global opportunity. So it’s, but it’s not gonna be everything. You know, people might. I might get a little bit heat for this, but [00:05:00] if you spread the jam too thin, it doesn’t taste very good. You haven’t committed to win a few things rather than come second and third everywhere. We have to choose what we win at.  Allen Hall: Let’s get into the industrial growth plan, ’cause I wanna understand that a little bit better and how OWGP. Fits in that as the delivery body. Right? So you have this industrial growth plan, OWGP is, is sort of administering it and, and taking action on it. How does this system work and, and why is it different than other attempts at supply chain development?  Peter Giddings: Uh, a couple of years ago, 2023, um, most of the major institutional stakeholders came together and said, oh, that we see this big opportunity coming. We want to make sure that the UK benefits from having all that deployment. So if you’ve got a bunch of demand and you [00:06:00] don’t have much supply, you don’t have as much supply as you want, that’s an obvious gap to fill. And the Crown of State, the Crown of State Scotland, the departments from government, the Offshore Wind Industry Council, a consortium of developers in the uk, uh, came together. Um. And funded a piece of work that allowed, um, a team to bring in lots of industry input. Look at what the big opportunities were in the market. So where is there substantial value? Where is there substantial demand? And match that up to where does the UK have capability and where could we grow a competitive advantage? So. What prizes are worth winning? What prizes can we win? And we’ve matched those up and there’s kind of five priority areas that we’ve selected. Um, it’s kind of the first things we’re gonna go after. Um, [00:07:00] they’re, they’re quite broad, those five. It’s advanced turbine technologies, deep water foundations, cable and electrical systems, uh, smart environmental services, and, uh, smart operations and maintenance. If you kind of open those boxes up, there are some very specific supply chains that are prioritized. So I’ll take the one that, uh, is the first one that we’re looking at. Advanced turbine technology. Uh, we talked just before we started recording, um, that the UK has real strength in blades. Blades is a big opportunity. We have a really well established composite industry. We have a great facility up in Hull. We have an r and d base and an onshore, um, factory on the isle of White with Vestas. And I think the thing we don’t really say is we have chief engineer for blades of Vestas in the UK structures lead. The r and d team is 140 strong down on the island [00:08:00] and we have a really productive facility in Hull. Um. That is putting product out, has been making, um, recyclable blades, is making the one 15. We have depth, so it’s a good opportunity. We have strength, we have a massive innovation ecosystem, so that’s a really obvious win. And we’ve been through the rest of the supply chain taking cables, good capacity, excellent experience from oil and gas, and so that’s a priority area. Okay. Going through those supply chains, finding big opportunities that the UK has, the ability to win contracts in, and then mapping out what do you need to do to make that capacity happen? How much capacity, at what cost, with what performance? And that’s, that’s kind of the OWGP role is owning that plan, bringing input from industry, [00:09:00] bringing input from experts. Turning the ambition of we want to have the ability to supply 50% of UK demand and export into a tangible plan of, cool, these businesses need this investment by this time to stand up a facility so they’re ready. It’s not just a blade factory. Right. That’s, um, that’s important. It’s the 20 businesses that sell product, that sell services into that. We talk about pyramids, right? You’ve got one facility at the top and a big wide base with lots of people who are employed in that big wide base. And I think, you know, it’s natural. Everybody looks to the top of the mountain. We’re looking to build the whole thing, and that’s a really powerful reason for industries to stay for the long term. So I think tracking back to your [00:10:00] question. What’s our role? We own that plan. We bring together the expertise and convert it into a set of measurable steps really. And that kind of second part is coordinate. Everybody needs to be playing the same game, aiming at the same targets. And that’s a really important part. Allen Hall: Well, I think for a lot of people outside the UK, it’s hard to envision the amount of industry that exists. In the UK you’re about 70 million people, so you’re roughly maybe a quarter of the population size of the United States roughly. But you’re, you, you have internal industries there and other areas that have that supply chain growth. So you’ve watched it in aerospace, which is one I’m familiar with, but in other industries, you, automobiles and a number of other areas, uh, you have that supply chain. So you know how to, the UK knows how to do that, but, but that hasn’t really necessarily happened in offshore wind, which I think is where the [00:11:00] opportunity is because I think watching. Being around this industry for as long as I have. One of the key elements is that, uh, the, the smaller businesses are sort of tier twos or tier threes that make the tier ones possible are kind of forgotten about. But the UK historically has looked at tier two and tier three as being the fundamentals to a successful product delivery and, and a, a global marketplace. Is, is that where the initial focus is? Because just listening to. And going to your website, uh, which I encourage everybody to do, you see where there’s smart decisions being made to create that base and what does that look like? And when you’re trying to attack that base on offshore wind, obviously cables and turbine technology, anything to do basically with being in the water, which the UK is great at. Do you see that being a relatively quick exercise because the UK has done it before in other industries? Or [00:12:00] is this problem just a little bit different because of the scale of it?  Peter Giddings: It’s really similar to, uh, the way supply chain’s been supported in aerospace, for example. Um, the Airbus has a deep supply chain in the UK and has a very strong voice into government. Their supply chain is supported. They’ve built that base. Um, and so from the outcome, that’s gonna be pretty similar? I think so. We, we have a template. I’ve worked in aerospace, many colleagues, um, that we’re, we’re calling on have, um, I guess the difference is, uh, maturity of industry. So the developers are very mature businesses. They’re global. They have been big for time. They know how to do supply chain development from oil and gas, where you build enormous unicorns. Exactly. Once, [00:13:00] then move on. You know, an oil and gas project is, is a one time deal. It’s tremendous, but you don’t have to make a hundred of them and it’s slightly different. So you end up with a, a single point, and if you are. Experience and your, um, relationship with government sits with developers that can create some really, um, it, it takes time to build up your supply chain so that they have the same experience of running, um, large development programs. They have the stability as businesses to kind of build through. It’s really important to remember that turbine OEMs and the tier ones haven’t had 30 years of stable business modeling wind. Because 30 years ago, wind wasn’t really a big industry, right? They have had plenty of success scaling their business, and we’re just entering the phase now where you can, um, pretty credibly say that wind is [00:14:00] a global business with a long-term future. And it needs to find the right way for those OEMs, those big tier one manufacturing businesses to support their business in the long term. That is, I would say quite new. Um, hopefully I don’t get pilled for saying that, but Airbus, spin Airbus for 2, 3, 4 generations. Right. So they know their game. Same with roles, same with, you know, Nissan and Toyota. It’s, it’s gonna take a little minute for the manufacturing part of the wind industry to settle and learn what works. We think OWGP and our partners, GB Energy, crown State, we think. We have a good starter for 10. You know, it’s modeled off what we’ve done in other industries. It provides stability, provides capital and a plan. I think that’s a really good mix. Um, [00:15:00] and I think it’ll just take a bit of time to mature those relationships and get everybody comfortable. Um, the developers have been really supportive. The OWGP money comes from. A developer contribution. So they are playing their part. Absolutely they are. We need to find the right way for manufacturing businesses to scale and then start pumping in innovations into that capacity so it stays competitive. You know, it’s a build capacity that’s competitive today. Feed it with innovation so it stays competitive and gets better and better and better.  Allen Hall: How far off the technology chain do you want them to be before you consider them to be part of the supply chain  Peter Giddings: today? Uh, 21st of January, 2026. There is good money for people that are within about a year of getting their technology to market. So that’s the, the approximate. Um, you’ll notice I dodge TRLI don’t think it’s super helpful. Um, time to market is, uh, is, is [00:16:00] really a good indicator. Yeah. Alan’s, give me the thumbs up of someone that’s done a TRL assessment or two. Um, we, we are looking for businesses that are commercially. Viable. They have relationships with customers. Um, they’re trading the earliest currently, and it’s currently, um, is like a year, maybe two years to market at the outside and up, um, we’re working with. And so that’s not just OWGP, that’s across the funding streams that are available. Um, and there are many we are working with and hopeful in the next week or two to have, um. A positive result from the UK government on earlier stage innovation funding so that we can align the early stage innovation at the problems that really count for making businesses competitive. You know, to be super clear, that’s not gonna be OWGP Cash. Our hope is that it’s OWGP derived questions [00:17:00] delivered by the innovation institute’s offshore renewable energy catapult, the high value manufacturing catapults. Academia, innovative businesses. Those guys do the innovation and we work together with them and with industry to really find the questions that count and we can focus our attention on commercializing that and scaling up the things that are commercial.  Allen Hall: Peter, walk us through how a UK supply chain company actually engages with OWGP. Uh, what does that. Uh, look like. And what are the, sort of the different options to, to engage with OWGP?  Peter Giddings: So I, I think the first thing to say is you, you don’t have to be UK today. We would love to attract businesses from overseas. Um, you can start a UK entity quite quickly. The first people, first place people tend to engage is in our, um, business, uh, support services. So we help, uh, businesses orientate themselves commercially. Understand how the contracting works, understand who [00:18:00] their, their pot potential customers are. Um, and that’s, yeah, it’s on our website. It’s Business Transformation Services, the West Program, wind Expert Services. There’s a t in there, there’s something else. Um, but that’s really the entry point for businesses that need to orientate themselves in the UK market. And we, and that. Intensity and the, the depth of the commercial support kind of ramps up through base and up to sig sharing in growth. Um, and you’ll also see us in the next year or two, um, take a, a more proactive approach to supporting businesses commercially. Um, I’m actually down with a, a fantastic business in the blade supply chain, um, composite integration in Saltash, helping them build a strategic, um, business plan. So a little more than just going, oh, this is where you get your contract. Actually helping them model what a future bigger business would look like and what they will need to do to, to reach it. You know, commercial support is growing for us. I think it could be really important, right? It’s [00:19:00] new for us, so, you know, we’ll learn. But the first point of call, go to the website, get in touch with the team, um, and often people choose that commercial support, the business transformation. We also run grant funding. Um, we have innovation calls. Um, we have a whole range of different calls going from innovation up to development into Dev X. So manufacturing, um, facility support program, they’re all grant. You can choose to pay them back. You do need to be UK entity, but you need to be quite close to market that one to two year zone with commercial traction. Um, and again, information is available. There is a team of people. Who are really great at taking those triaging, figuring out what’s right for you, what’s not, and if it’s not something from us, we do and we are delighted to pass you on to other people. You know, if you talk to us, we will make sure you find a home.[00:20:00] I think that’s really important to say.  Allen Hall: I think that’s very critical and one of the more difficult. Periods for, uh, it’s a smaller company to become bigger and be part of this massive supply chain, is that sort of 1 million pound, the 5 million pound kind of business, which has a technology which has proven itself and is delivering something or very close to delivering something. That transition is incredibly hard and getting some help there and some advice even would make the transition so much shorter and more efficient than what it typically is. That’s what OWGP does. So it’s not just the money. Obviously money helps everything generally. It’s the context, it’s the advice, it’s the knowledge that, uh, OWGP brings to the table that helps you grow your technology, your small business, into that mid-tier business and takes that mid-tier business into that gigantic world leader business. Those are the things that are, [00:21:00] are so hard to quantify, to put some, uh, some people in place. Boy, OWGP can really ramp up and has, the UK in general has done this many, many times. So I, I, I just encourage everybody who’s listening to this podcast to think about OWGP as a contact point and reach out. And Peter, how can they do that? What are the first steps to contact OWGP?  Peter Giddings: It’s always best to come in through our website. So my contact details will be in the, um, in the show notes, but you, you can look at the different programs there are contact US buttons all over it. Um, it also gives you sight of the industrial growth plan, um, and the priority areas. We are trying where we can to focus our efforts on those priority areas, and we would absolutely be delighted to hear from businesses active in the IGB priorities. Um, if you are, if you are not in one of those, you’re not excluded, come talk to us and we, we are supporting ambitious [00:22:00] businesses. We’re just focusing most of our efforts on the ones that are aligned to priority. We’re, we’re on your team. We would like to hear from you. Um, yeah, do, do start with the website. Hit one of the contact buttons you’ll come into to one of the team and we will connect you in. Um, I think that’s probably the, the best way  Allen Hall: and the website is ow gp.org.uk. Very easy to get to. You can just Google it and it’ll come right up. There’s a ton of information on that website. Peter, thank you so much for being on the podcast. I really appreciate this. Learned a lot and very excited for what the UK is about to do.  Peter Giddings: I’m looking forward to talking to you again.

In this episode of Med Tech Gurus, we welcome Neil Klompas, Chief Executive Officer of Augurex Life Sciences. With more than two decades of experience leading companies at the intersection of diagnostics, rheumatology, and translational medicine, Neil is pioneering a new era of autoimmune biomarker discovery. Under his leadership, Augurex developed SpineStat, the world's first blood test designed to identify axial spondyloarthritis (AxSpA)—a chronic inflammatory spinal disease that affects millions yet often goes undiagnosed for nearly a decade. By leveraging the anti-14-3-3η autoantibody in combination with CRP, SpineStat is helping clinicians detect disease earlier, prevent irreversible spinal damage, and even reduce opioid dependence through faster, targeted treatment. Neil shares how engaging early with regulators helped Augurex earn FDA Breakthrough Device Designation, why he believes rheumatology is poised for its "oncology moment," and how keeping his team centered on the patient journey drives innovation every day. If you're passionate about precision diagnostics, regulatory navigation, and building mission-driven teams, this episode is a masterclass in turning unmet medical need into measurable clinical impact.

Join us for another riveting episode of Coffee Time Wednesday. Today we discuss Bayer's Tort Immunity at the federal level and the chance they have at succeeding. We also talk about Iowa Secretary of Ag Mike Naig's recent conversation about grazing CRP.    Hoksey Native Seeds (for Midwest CRP Mixes, Wildflower Patch Mixes, and More) Iowa Cover Crop (For all your cover crop and small grain needs) McKay Insurance (For a better insurance experience)

Host Erin Kerry interviews internationally recognized naturopathic physician and functional medicine leader Dr. Jaquel Patterson to unpack why anxiety, depression, and ADHD are skyrocketing…and why medications often stop working. Dr. Patterson explains the missing link between chronic inflammation, infections, gut health, and neuropsychiatric symptoms — especially in kids and teens. They discuss the labs your doctor may not be running, how to identify biological drivers of mental health struggles, and why functional medicine looks beyond “normal” ranges to find what's optimal. Key Topics: - Chronic inflammation and how it disrupts the blood-brain barrier, neurotransmitters, and medication effectiveness - The biological drivers behind rising rates of anxiety, depression, and ADHD - Why standard labs miss key issues — and the optimal ranges that matter (ferritin, cortisol, thyroid, CRP, IL-6, ESR, testosterone) - How infections, including strep, Lyme disease, and tick-borne co-infections impact behavior, mood, and cognition - Understanding PANS/PANDAS and sudden-onset OCD, anxiety, and tics in children - The role of gut health, antibiotic exposure, and microbiome repair in brain development - Nutritional supports for kids: amino acids, protein intake, lithium orotate, beef liver, and micronutrients - Mold and environmental toxicity: why symptoms often get misdiagnosed as psychiatric - When medications stop working — and the physical issues to rule out - Practical first steps: blood work, environmental assessments, and small habits for long-term healing Links: Website: http://fairfieldfamilyhealth.com Facebook:       https://www.facebook.com/drjaquel/ Instagram:       https://www.instagram.com/naturopathic.physician/

Have you ever been told your labs are “normal” — but you don't feel normal?In this episode, I sit down with integrative and functional medicine physician Aaron Hartman, author of Uncurable, to unpack the dangerous gap between normal and optimal — especially for women in midlife.We cover:What lab reference ranges really meanThe cardiovascular markers every woman should know (hs-CRP, LDL particle number, Lp(a), ApoB, homocysteine)Why LDL alone is outdated thinkingThyroid testing beyond TSH (free T3, free T4, reverse T3, antibodies)Ferritin, B12, iodine & nutrient blind spotsEstrogen, progesterone & testosterone — when to start and what actually protects your brain and heartStatins, diabetes risk, and mitochondrial healthGut health, inflammation & autoimmune triggersWhy lifestyle is foundational — and where advanced longevity tools fit inDr. Hartman explains how heart disease begins decades before symptoms appear, why hormone replacement therapy dramatically reduces risk when used appropriately, and how women can advocate for themselves in a system that often dismisses midlife symptoms.If you care about your brain, your bones, your heart — and living strong into your 80s and 90s — this conversation is essential.Did you miss something? Check out the transcripts of the episode!You can find Aaron Hartman, MD at https://richmondfunctionalmedicine.com/Instagram https://www.instagram.com/aaronhartmanmd/His book, Uncurable: From Hopeless Diagnosis to Defying All Odds, is available where you buy books. _________________________________________If you're doing “all the right things” and still feel stuck, adding a layer of support may be an option. I've partnered with a trusted telehealth platform offering modern solutions for women in midlife—including micro-dosed GLP-1 and other peptide therapies. https://elliemd.com/michelefolan - Create a free account to view all products. Follow us on Instagram https://www.instagram.com/askingforafriend_pod/ ✨ Sign up for my weekly newsletter: https://michelefolanfasterway.myflodesk.com/i6i44jw4fq Like to connect? Email me at askingforafriendpodcast1@gmail.com Transcripts are created with AI and may not be perfectly accurate. Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your qualified healthcare provider with any questions regarding a medical condition.

In this episode of Get Real or Die Trying, host Amadon DellErba sits down with Brit Arthur—founder of http://AutoimmuneDiseaseAwareness.com, CEO and designer of BeachCandy Organics (the trailblazing organic swimwear brand), holistic healer, and creator of the Feast to Wellness Protocol—for a fierce, unfiltered confrontation with autoimmune disease and the toxic systems designed to keep us dependent and unwell. Filmed on-location at Avalon EcoVillage.Brit delivers her story without apology: decades of hidden suffering—asthma, acne, body odor, gut chaos, and escalating inflammation that exploded into spinal autoimmune disease at 34, complete with genetic markers and CRP levels screaming cancer territory. Doctors pushed lifelong steroid injections and heavy pharma; she endured a year of minimal gains before walking away in fury at a system that silences symptoms instead of healing roots. She plunged into gut biome research, Ayurveda, Chinese medicine, herbalism, detox protocols, and non-toxic truth—then committed fully to plant-based living, toxin elimination, and radical simplicity.The shift was explosive: joint pain and immobility dissolved in days. From needing help to turn doorknobs and being carried from bed, she climbed 8 grueling miles with a 60-pound pack months later. Her Feast to Wellness Protocol—165+ anti-inflammatory, medicinal recipes plus daily detox rituals—has now empowered over 30,000 people globally to claim symptom-free lives from every corner of the planet.Amadon and Brit tear into the heart of it:The medical and food industries that suppress rather than solve—pushing seed oils, ultra-processed garbage, mycotoxin-laden grains, GMOs, pork's toxin accumulation, and endless chemicals while ignoring root causes like glyphosate, plastics, and emotional baggageShattering hustle culture, plastic dependency, restaurant traps, and inflammatory poisons that quietly destroy usThe freedom of minimalism in India, authentic Ayurvedic immersion, copper-charged water, farmers market allegiance, and transforming every meal into medicineWhere spirituality collides with biology: how toxic thoughts, chronic judgment, fear, unresolved trauma, and victim attachment literally manifest disease—and why forgiveness, embracing discomfort, emotional alchemy, and genuine loving connection are essential for extreme, integrated healthThe urgent poisoning of our supply chain, the call for real outrage and collective rebellion, and why every choice—what we eat, wear, think, buy—is sacred resistance and stewardship of body, land, and futureThis isn't soft self-care—it's a battle cry to wake up, purge the poisons (physical, emotional, systemic), reject the "pill up and power through" deception, and seize vibrant, liberated living on your own fierce terms. If you're done suffering quietly, questioning the chemical matrix and quick-fix lies, or ready to turn pain into unbreakable purpose—this raw exchange will set you ablaze.

Kun je met CRP in liquor sneller en betrouwbaarder onderscheid maken tussen bacteriële meningitis en andere oorzaken van liquorafwijkingen?In deze nieuwe BrainWave bespreken we de diagnostische waarde van CRP in liquor bij verdenking op bacteriële meningitis. We gaan in op de wetenschappelijke onderbouwing, sensitiviteit en specificiteit, en de praktische meerwaarde naast klassieke liquorparameters in de acute setting.Te gast is Sabine Olie, aios neurologie in het Amsterdam UMC, die promoveerde op diagnostiek bij verdenking op centrale zenuwstelselinfecties en specifiek onderzoek deed naar CRP in liquor.Een actuele en evidence-based verdieping voor iedereen die werkt in de acute neurologie. Luister mee! 

In this episode, David Watumull breaks down the science behind astaxanthin — a powerful carotenoid antioxidant backed by over 4,000 peer-reviewed papers and 100+ human clinical trials — and explains why it may be one of the most underappreciated longevity compounds available today. The conversation explores how astaxanthin anchors across cellular membranes to protect mitochondria from oxidative stress, reduce chronic inflammation ("inflammaging"), support cardiovascular health by lowering oxidized LDL and CRP, and cross the blood-brain barrier to enhance cognitive function and neuroprotection. They also discuss its role in energy production, endurance performance, healthy aging, and a landmark NIH lifespan study showing a 12% extension in mammals. Ultimately, the episode reframes longevity not as chasing stimulants or shortcuts, but as protecting cellular integrity so the body can function the way it was designed to — for longer and at a higher level. ----- 00:00 – The Longevity Molecule You've Never Heard Of 02:45 – What Is Astaxanthin? 07:30 – How It Protects Your Cell Membranes 13:40 – Free Radicals & Oxidative Stress Explained 25:50 – Brain Health, Neuroplasticity & Mitochondria 29:40 – Cardiovascular Disease & Oxidized LDL 34:05 – Alzheimer's, MCI & Neuroprotection 43:00 – Energy Production & Mitochondrial Function 58:40 – Inflammaging & Longevity Pathways 1:03:40 – NIH Study: 12% Lifespan Extension 1:09:00 – Athletic Performance & Endurance 1:15:00 – Dosing, Absorption & Bioavailability 1:26:00 – Can Antioxidants Become Harmful? 1:30:00 – Why Isn't This Mainstream? 1:37:30 – Living Ever Forward ----- Episode resources: Save 20% with checkout code EVERFORWARD at https://www.AX3.Life.com Watch and subscribe on YouTube Learn more at https://ax3.life/pages/science 

Respiratory disease, including infections, affects one in five people in England and is the third biggest cause of death, with around 68,000 annual deaths.In this podcast Dr Thomas Round talks to Professor Paul Little, a GP and Professor of Primary Care Research at the University of Southampton about respiratory tract infections. They provide a discussion on the common presentations to primary care including symptoms and their duration, natural history, assessment (triage), red flags, treatment including best practice for the use of antibiotics (NNT and NNH, TARGET toolkit), point of care testing (CRP), the use of nasal sprays, encouraging at risk groups to receive vaccinations, continuation of hand washing, and the impact of stress on illness. They also offer top tips for everyday practice.Further reading: RCGP Essential Knowledge Update Hot Topic: Nasal sprays and behavioural interventions compared with usual care for acute respiratory illness in primary care RCGP TARGET antibiotics toolkit hub Little P, Vennik J, Rumsby K, et al. Nasal sprays and behavioural interventions compared with usual care for acute respiratory illness in primary care: a randomised, controlled, open-label, parallel-group trial. Lancet Respir Med. 2024 Aug;12(8):619-632.  Little P, Stuart B, Andreou P, et al. Primary care randomised controlled trial of a tailored interactive website for the self-management of respiratory infections (Internet Doctor). BMJ Open. 2016 Apr 20;6(4): e009769. RCGP Podcast FeedbackYour feedback plays a crucial role in helping us improve the CPD products and services we offer. We would be grateful if you could please complete our short RCGP Podcast Survey, which will take no more than 5 minutes to complete.

In this episode of Farm Companion, we break down the reality of managing a hunting farm and the scope of work happening across our properties right now. From EQIP planning and CRP programs to timber harvests, TSI work, and long-term habitat strategy, we talk through the projects, decisions, and lessons that come with trying to improve land for both deer and the future. Managing a farm is never a finished process, and this time of year is when many of those plans start to take shape. Sit back, relax, and enjoy the show.SUBSCRIBE TO THE CHANNEL:https://www.youtube.com/c/HUNTRTUBEShop HUNTR Merch:https://wearehuntr.com/HUNTR Podcast is presented by:Hoyt Archery: https://hoyt.com (Code HUNTR for 20% off apparel)DeerGro: https://www.deergro.com (Code HUNTR for 15% off)Predator Camo: https://www.predatorcamo.com/ (Code HUNTR for 20% off)Beast Broadheads: https://beastbroadheads.com/ (Code HUNTR for 10% off)Lone Wolf Custom Gear: https://www.lonewolfcustomgear.com/ (Code HUNTR for 10% off)RackHub: https://www.rack-hub.com/huntr (Code HUNTR for 10% off)Pure Wildlife Blends: https://www.purewildlifeblends.com (Code HUNTR for 10% off)Primos: https://www.primos.com/ (Code HUNTR for 15% off)Bushnell: https://www.bushnell.com/ (Code HUNTR for 15% off)HHA: https://www.hhasports.com/

BUFFALO, NY — February 27, 2026 — A new #research paper was #published in Volume 18 of Aging-US on February 6, 2026, titled “Causal effects of inflammation on long-term mortality: a Mendelian randomization study.” Led by Eliano P. Navarese from Department of Life and Health Sciences, Link Campus University and SIRIO MEDICINE Research Network, Nicolaus Copernicus University, who is also the corresponding author — the study used large-scale Mendelian randomization (MR) to test whether genetically proxied levels of inflammatory biomarkers causally influence long-term all-cause mortality. The analysis combined genome-wide association instruments from more than 750,000 individuals and used FinnGen mortality data (median follow-up 11.7 years) to assess effects on overall survival and major cardiovascular endpoints. Using robust MR methods and multiple sensitivity analyses, the authors report that genetically higher IL6R (soluble IL-6 receptor) levels were associated with reduced all-cause mortality (odds ratio per 1-SD increase: 0.95; 95% CI: 0.91–0.98), and with lower risk of atrial fibrillation, coronary artery disease, stroke, and lung cancer. By contrast, genetically higher IL6 levels were associated with increased mortality (OR 1.05; 95% CI: 1.02–1.08). No significant causal effects were observed for CRP or GDF15, suggesting those markers more likely reflect disease burden than drive it. “These results support IL6R antagonism as a potential strategy for cardiovascular disease prevention.” The authors emphasize that the opposing directions for IL6 and IL6R point to distinct biological mechanisms: IL6 likely promotes chronic pro-inflammatory states that increase cardiovascular risk, while higher circulating IL6R (reflecting altered receptor shedding and signaling) appears to dampen harmful IL6 activity at the vessel wall and myocardium, yielding cardiovascular protection. Sensitivity and cis-MR analyses reinforced the IL6R protective signal and showed minimal evidence of directional pleiotropy. Together, the genetic evidence aligns with clinical trial data for IL6R antagonists in other settings and supports further evaluation of IL6R-targeted strategies for cardiovascular prevention. The paper also notes important limitations and next steps. Analyses were restricted to individuals of European ancestry, so results require replication in other ancestries. Translating genetic evidence into preventive therapies will need careful clinical evaluation, long-term safety assessment, and trials designed for primary prevention in high-risk populations. The authors also call for additional mechanistic work to map how IL6/IL6R modulation alters vascular inflammation and downstream disease processes. DOI - https://doi.org/10.18632/aging.206352 Corresponding author - Eliano P. Navarese - elianonavarese@gmail.com Abstract video - https://www.youtube.com/watch?v=Br1A0jgU-4M Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206352 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, mendelian randomization, inflammatory biomarkers, mortality, cardiovascular disease To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Hidden fat stored deep inside organs, especially the pancreas and abdomen, links to brain shrinkage, cognitive decline, and a higher risk of neurologic disease even when your weight looks normal An MRI-based study of 25,997 adults found that fat distribution patterns inside the body predict brain aging and cognitive outcomes more strongly than body mass index (BMI) alone People with high pancreatic fat showed around 30% fat concentration in the pancreas, which was up to six times higher than lean individuals and tied to extensive gray matter loss The "skinny fat" profile involved high internal abdominal fat despite only moderate BMI, with men showing the steepest decline in brain volume and slower thinking speed Simple metabolic assessments like fasting insulin, HOMA-IR, CRP, lipid profiles, and waist-based ratios offer practical ways to detect hidden risks early, before obvious symptoms appear

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Michael: Hi Dr. Cabral. I'm an IHP Level 1 and have been following you for over 2 years. I'm grateful for all you do. I'm a 61 year old male and take no medication. I've always had elevated cholesterol but it's come down a lot over the last 2 years. I now have LDL of 108. My CRP is in the normal range at 0.41. My homocysteine is also in the normal range at 8.9. My coronary calcium score from almost 3 years ago is 129. I want to make sure my heart stays healthy and want to be smart about what supplements to take apart from the foundational ones like the DNS and Omega 3. If I take all the supplements that promote a healthy heart, it gets a bit expensive and I was wondering if you thought about formulating one supplement to combine some of them. I'm currently taking D3+K2, Red Yeast Rice, Berberine and Inflamma Soothe, and I'm considering adding in Proteolytic Enzymes. What are your thoughts on which ones to prioritize?      Lily: Hi Doc, I am taking the foundational supplements and magnesium. I know that everyone is different and the personal approach is best (I just ordered your new book). But, if you had to say, beyond the foundational supplements, what are your next 4 favorite supplements?      Tommy: Hi Dr C, I'm An IHP 2. I've come a long way with my health and career thanks to you. I've had many issues in life similar to you. In the last 2 years I feel like I've become very prone to gut issues. I've done 2 para and 1 CBO in the last year. I seem to get bouts of dhiarrea like I've picked up a bacteria. I have wondered if my stomach acid is low, being an online presence is stressful, but I'm working on my stress more than ever. What else could cause me to have a 'weak stomHawkins: ach'? I still get anal itching too, sometimes during the day, I know you've mentioned this could also be histamines and not just parasites. I've had so much trauma, antibiotics, and 14 years of steroid creams. I've had low cortisol too which I believe is much better now.      Scott: Hi Stephen. (Scott UK) . My wife had a routine operation (9 operations in total) and ended up with stomach problems diagnosed with gastroparesis, well that's what they said, she ended up with a feeding tube and an ileostomy, in the last couple of years she's really turn thing around she's back to solid food and she hasn't fed on her feeding tube for 9 to 10 months now, she's gaining weight and looking really healthy, she's 53 and going through menopause, she's been diagnosed with carpal tunnel and trigger finger in both hands, and both thumbs are now stuck straight, she takes half of a scoop of DNS and greens powder, D3k2. magnesium, zinc, omega 3, infrared sauna, red light, 7000 steps, they want to operate on both hands,which I'd like to avoid, any suggestions would be very helpful.      Stephanie: Hi! I had a full work up done and it showed my prolactin level is 95. CRP also elevated, but everything else within range. I am willing to go see an endocrinologist, but I am hesistant to take the cabergoline (I've read that's likely how they will proceed). Is there anything else I can do? I started taking Vitex Berry when I got the results.      Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3669 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

This is a major episode of Talk Dirt To Me, covering some of the biggest stories currently impacting American agriculture, rural landowners, and national farm policy. We begin with the story of Gregory Family Farm in Sumner County, Tennessee, and their ongoing battle with the Tennessee Valley Authority (TVA) over eminent domain. This situation raises serious questions about private property rights, government authority, and what happens when multi-generation farmland stands in the path of federal infrastructure projects. We explain what is happening, why it matters beyond Tennessee, and what this case could mean for farmers and landowners across the country. Next, we break down President Trump's executive action protecting Glyphosate and Phosphorus and discuss why the decision is tied not only to agriculture but also to food security and national security. We examine how crop protection tools affect American production capacity, global competitiveness, and the stability of the U.S. food supply. The conversation then turns to an in-depth look at Farm Bill 2.0. This episode serves as our first comprehensive breakdown of the new legislation and what it includes for farmers and rural communities. Topics covered include strengthened farm safety nets, conservation funding through EQIP and CRP programs, efforts to improve export competitiveness, pesticide liability protections, increased farm loan limits, and provisions aimed at limiting the nationwide impact of California's Proposition 12. We also discuss potential concerns and areas that may change as amendments continue to shape the bill. We will continue updating listeners as new developments occur. Along the way, the episode includes classic Talk Dirt To Me conversation, including Memphis rap nostalgia, Logan's story about an interview with a legacy media outlet that will likely never air, and a recap of our experience at the National Farm Machinery Show in Louisville. Made in USA Product of the Week: the suppressor cover from T and K Hunting Gear, built for durability and performance in the field. If you want real discussions about farming, policy, rural America, and the culture surrounding agriculture, this episode delivers an in-depth and honest conversation you will not hear anywhere else. Go check out Agzaga! It is the ultimate online farm store. American owned and operated. Go check out their site and get what you need. Be sure to use the code TalkDirt20 to get $20 off your order of $50 or more! Visit them at: https://agzaga.com 

Understanding and Managing Heart Health: In this Heart Health Month episode of the Intelligent Medicine Podcast, nutritionist Leyla Muedin addresses a listener's question about elevated cholesterol levels and calcium scores. Drawing on an article written by Dr. Hoffman, she emphasizes the importance of discussing statin use with a doctor, considering individual risk factors, and getting additional tests like VAPs, NMR, homocysteine, and lipoprotein levels. The episode explores the importance of vitamins K2 and folate in cardiovascular health, addressing nutritional deficiencies, and the impact of dietary choices on heart health.

In this episode of the *Innovations and Clinical Implementation* podcast recorded at LongevityFest, hosts Tom Blue and Chris D'Adamo discuss the rapid evolution of epigenetic testing with Ryan Smith. Ryan Smith is the founder and global head of research and development at TruDiagnostic, a CLIA-certified lab and health data company that has built one of the world's largest private epigenetic databases to advance the measurement of biological aging. The discussion traces the 140% year-over-year growth in consumer interest regarding biological age and explores how TruDiagnostic utilizes AI to interpret over 1.3 million DNA methylation sites to validate longevity interventions in clinical trials. Smith previews the upcoming release of "methylation risk scores" that can predict the onset of diseases like COPD and Lyme disease, and details the development of "Epigenetic Biomarker Proxies" (EBPs) intended to eventually replace traditional labs by deriving thousands of metrics—such as HbA1c, CRP, and environmental toxins—from a single finger stick.   For access to episode resources, click HERE.

Independent filmmaker Christina Shaver discusses two projects in Aledo. One involves the film "Everything Fun You Could Possibly Do in Aledo, Illinois" and the other involves a documentary film on late Aledo artist Gertrude Abercrombie.  Bill Graff, State Executive Director USDA-FSA and Shelley Sweatman, Illinois Conservation Division Chief USDA-FSA, talk CRP sign-up.  DTN ag meteorologist John Baranick discusses the possibility for severe weather on Thursday.  

This week, Tony shares a morning report physiology pearl: Why do patients with active lupus have a low CRP? Click here to obtain AMA PRA Category 1 Credits™ (0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 hours). Audio edited by Clair Morgan of Nodderly.com. Resident Giancarlo Buonomo and medical student Millennium Manna are our producers.

You've heard of burnout. But what if the real crisis starts long before the breaking point? In this short opener, host Stacie introduces allostatic load — the scientific term for the cumulative "wear and tear" the body accumulates under chronic, unresolved stress. It's not a bad week. It's what happens when the body never fully recovers, and the nervous system learns to treat survival mode as its new normal. Research shows women carry a disproportionate allostatic burden — driven not just by biology, but by the invisible labor, emotional weight, and systemic pressures that don't clock out at 5pm. And for leaders and HR professionals, this matters: what often looks like a performance problem in your workforce may actually be a health signal hiding in plain sight. This episode opens a series that follows allostatic load where it leads — into autoimmune disease, hormonal disruption, ADHD, and what it truly costs women, leaders, and organizations when we keep misreading the signal. Under 5 minutes. But it might change how you see everything else. Stacie Origins of the Term The concept of allostasis — meaning "stability through change" — was first introduced by neurobiologist Peter Sterling and epidemiologist Joseph Eyer in 1988 to describe how the brain dynamically recalibrates internal physiological systems in anticipation of environmental demands, rather than simply reacting to them. Building on this foundation, neuroscientist Bruce McEwen and physiologist Eliot Stellar coined the term allostatic load in 1993, defining it as the cumulative physiological "wear and tear" the body experiences when allostatic systems are chronically activated, fail to shut off, or never perform normally. McEwen later described this as "the price of adaptation" — the physiological cost the body pays for sustained attempts to manage chronic stress. The Biological Cascade: What Happens in the Body When the brain perceives a stressor — real or anticipated — it activates two primary physiological systems: the sympathetic-adrenal-medullary (SAM) axis, which releases catecholamines (adrenaline, noradrenaline), and the hypothalamic-pituitary-adrenal (HPA) axis, which releases glucocorticoids, primarily cortisol. In the short term, these responses are adaptive and protective. However, under conditions of chronic, unresolved stress, this cascade remains activated. Over time, the brain and organ systems undergo measurable physiological changes: ↑  Elevated cortisol, epinephrine, and norepinephrine (neuroendocrine markers) ↑  Elevated inflammatory markers: C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen ↑  Dysregulated blood pressure, lipid levels, glycated hemoglobin (metabolic markers) ↓  DHEA (dehydroepiandrosterone) — the protective counterpart to cortisol A 2001 landmark study using the MacArthur Studies of Successful Aging demonstrated that higher allostatic load scores at baseline were significantly associated with increased 7-year mortality risk and declines in both cognitive and physical functioning. A comprehensive 2020 systematic review of 267 studies confirmed that allostatic load and allostatic overload are robustly associated with poorer physical and mental health outcomes across a wide range of conditions.

30-Day Anti-Inflammatory Challenge PodcastFIVE PRIMARY POINTS of the PODCASTPurpose and closeness are biologically linked drivers of vitality.Research involving over 8,000 people shows that a strong sense of purpose explains much of the relationship between loneliness and mortality, reinforcing that vitality cannot be optimized in isolation.Loneliness is a serious health risk—not just an emotional state.It is associated with cardiovascular disease, dementia, suicide, increased inflammation (including higher CRP levels), reduced resilience, and cognitive decline, demonstrating that social connection is fundamental to long-term health.Closeness must be intentionally cultivated.High-quality relationships may matter more than traditional risks like smoking or obesity. Practical strategies include practicing forgiveness, building a “vitality squad” of about four trusted friends, actively listening, and scheduling regular in-person connection.Purpose functions as a longevity enhancer and performance differentiator.A study of more than 13,000 people found that those with a high sense of purpose had less than half the mortality risk of those with low purpose. Purpose guides how we invest time and energy and acts as a powerful motivational engine.Identifying purpose requires reflection, experimentation, and service to others.Key steps include clarifying values, recognizing strengths, stepping outside comfort zones, seeking guidance, and refining a concise purpose statement. Ultimately, meaningful actions sustained over time—and focusing on improving others' lives—lead to a meaningful life.Copyright, VyVerse, LLC. All Rights Reserved. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit vitalityexplorers.substack.com/subscribe

This episode of EM Pulse dives into one of the most stressful scenarios in the ED: the febrile infant in the first month of life. Traditionally, a fever in this age group has meant an automatic “full septic workup,” including the dreaded lumbar puncture (LP). But times are changing. We sit down with experts Dr. Nate Kuppermann and Dr. Brett Burstein to discuss a landmark JAMA study that suggests we might finally be able to safely skip the LP in many of our tiniest patients. The Study: A Game Changer for Neonates Our discussion centers on a massive international pooled study evaluating the PECARN Febrile Infant Rule specifically in infants aged 0–28 days. While previous guidelines were conservative due to a lack of data for this specific age bracket, this study provides the evidence we've been waiting for. The Cohort: A large pool of infants across multiple countries. The Findings: The PECARN rule demonstrated an exceptionally high negative predictive value for invasive bacterial infections. The Big Win: The rule missed zero cases of bacterial meningitis. Defining the Danger: SBI vs. IBI The experts break down why we are shifting our terminology and our clinical focus. Serious Bacterial Infection (SBI)  Historically, this was a “catch-all” term including Urinary Tract Infections (UTIs), bacteremia, and meningitis. However, UTIs are generally more common, easily identified via urinalysis, and typically less life-threatening than the other two. Invasive Bacterial Infection (IBI)  This term refers specifically to bacteremia and bacterial meningitis. These are the “high-stakes” infections the PECARN rule is designed to rule out. Dr. Kuppermann notes that we should ideally view bacteremia and meningitis as distinct entities, as the clinical implications of a missed meningitis case are far more severe. The HSV Elephant in the Room One of the primary reasons clinicians hesitate to skip an LP in a neonate is the fear of missing Herpes Simplex Virus (HSV) infection. Low Baseline Risk: While the overall risk of HSV in a febrile infant is low, the risk of “isolated” HSV (meningitis without other signs or symptoms) is even rarer. Screening Tools: Most infants with HSV appear clinically ill. Clinicians can also use ALT (liver function) testing as a secondary screen – transaminase elevation is a common marker for systemic HSV. Clinical Judgment: If the baby is well-appearing, has no maternal history of HSV, no vesicles, and no seizures, the risk of missing HSV by skipping the LP is exceptionally low. Practical Application: Shared Decision-Making This isn’t just about the numbers—it’s about the parents. “Families don’t mind their babies being admitted… They do not want the lumbar puncture. It is the single most anxiety-provoking aspect of care.” — Dr. Brett Burstein The PECARN “Low-Risk” Criteria:  (Remember, this rule applies only to infants who are not ill-appearing.) Urinalysis: Negative Absolute Neutrophil Count (ANC): ≤ 4,000/mm³ Procalcitonin (PCT): ≤ 0.5 ng/mL The Bottom Line: If an infant is well-appearing and meets these criteria, physicians can have a nuanced conversation with parents about the risks and benefits of forgoing the LP, while still admitting the child for observation (often without empiric antibiotics) while cultures brew. Key Takeaways The “Well-Appearing” Filter: If an infant looks ill, the rule does not apply. These patients require a full workup, including an LP, regardless of lab results. Meticulous Physical Exam: Assess for a strong suck, normal muscle tone, brisk capillary refill, and any rashes or vesicles. History is Key: Always ask about maternal GBS/HSV status, pregnancy or birth complications, prematurity, sick contacts, and any changes in feeding, stooling or activity. Procalcitonin: PCT is the superior inflammatory marker for this rule. If your facility only offers traditional markers like CRP, the PECARN negative predictive value cannot be strictly applied. In the words of Dr. Kuppermann: “If you don’t have it, for God’s sakes, just get it! ALT to Screen for HSV: While not part of the official PECARN rule, our experts suggest that significantly elevated liver enzymes should raise suspicion for systemic HSV. Observe, Don’t Discharge: Being “low risk” does not mean the infant goes home. All infants ≤ 28 days still require admission for 24-hour observation and blood/urine cultures. We want to hear from you! Does this change how you approach febrile neonates in the ED? How do you handle shared decision-making with parents? Connect with us on social media @empulsepodcast or on our website ucdavisem.com. Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Professor of Emergency Medicine at UC Davis Guests: Dr. Nate Kuppermann, Executive Vice President and Chief Academic Officer; Director, Children’s National Research Institute; Department Chair, Pediatrics, George Washington University School of Medicine and Health Sciences Dr. Brett Burstein, Clinician-Scientist and Pediatric Emergency Medicine Physician at Montreal Children’s Hospital, McGill University Resources: Burstein B, Waterfield T, Umana E, Xie J, Kuppermann N. Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger. JAMA. 2026 Feb 3;335(5):425-433. doi: 10.1001/jama.2025.21454. PMID: 41359314; PMCID: PMC12687207“Hot” Off the Press: Infant Fever Rule “Hot” Off the Press: Infant Fever Rule Do I really need to LP a febrile infant with a UTI? PECARN Infant Fever Update: 61-90 Days Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections. JAMA Pediatr. 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. PMID: 30776077; PMCID: PMC6450281. Pantell RH, Roberts KB, Adams WG, Dreyer BP, Kuppermann N, O’Leary ST, Okechukwu K, Woods CR Jr; SUBCOMMITTEE ON FEBRILE INFANTS. Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old. Pediatrics. 2021 Aug;148(2):e2021052228. doi: 10.1542/peds.2021-052228. Epub 2021 Jul 19. Erratum in: Pediatrics. 2021 Nov;148(5):e2021054063. doi: 10.1542/peds.2021-054063. PMID: 34281996. ****Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.  

Midlife health is about far more than a single lab value. In this episode, we talked about how hormones, muscle mass, cholesterol, and inflammation influence long term heart and metabolic health. If you've ever felt overwhelmed or confused by what to focus on, we're bringing the clarity and direction to make it easier on you!Timestamps:[1:50] Welcome[11:52] I saw a post that said muscles in our legs help us have longevity and our calf muscles are like the second heart in the body. I'm assuming there's some truth, but does that just mean to continue to strike train and to walk?[24:56] How do you know if you're in peri-menopause? I feel like everything is a symptom.[37:24] What are the pros and cons of muscle splits vs. whole body workouts?[45:25] What dietary guidance do you have for lowering high total cholesterol? Episode Links:Kicking Back Cognitive Aging: Leg Power Predicts Cognitive Aging after 10 Years in Older Female TwinsSeeking Health DAO enzymeSeeking Health Histamine ProbioticThyroid Markers to check: TSH, Free T4, Free T3, Thyroid peroxidase antibodies (TPO), Thyroglobulin antibodies (TGAb)Additional cholesterol markers to check: ApoB, LDL-P, hs-CRP, fasting insulinSponsors:Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.Go to getkion.com/wellfed to get 20% off your order. Go to http://mdlogichealth.com/wfcolostrum , and use coupon code WFC15 for 15% off. You can also use code WELLFED for 10% off site wide on all MD Logic Products. Go to wellminerals.us/vitaminc and use code WELLFED to get 10% off your order.

Weight frustration in perimenopause isn't just about vanity—it's about a physiological shift that changes how our bodies handle fuel. In this episode, Dr. Rachel Pope sits down with midlife health expert Ann Konkoly to demystify GLP-1 medications (like Ozempic and Zepbound), the hidden dangers of visceral fat, and why the scale is often a "shitty measurement" for your actual health.In this episode, we discuss: The "Middle" Mystery: Why the "eat less, move more" mantra fails women in perimenopause and how this transition impacts weight maintenance. GLP-1s Beyond Weight Loss: Ann explains the metabolic benefits of these medications, including reducing neuroinflammation and protecting the heart and kidneys. The Hidden Danger of Visceral Fat: Why a "normal BMI" can be misleading and how internal fat affects your risk for chronic disease. Synergy with MHT: How optimizing cardiovascular health can create a safer "on-ramp" for starting hormone replacement therapy. Preserving Lean Muscle: Strategies for "muscle-centric medicine" to ensure weight loss doesn't come at the expense of your strength and bone density. The HOMA-IR Hack: A simple way to use fasting glucose and insulin levels to see if insulin resistance is your primary roadblock. Planning for your later years: Why the choices you make in your 40s and 50s determine your mobility and independence in your 80s and 90s.The "Proactive Midlife" Lab ChecklistAnn suggests asking your provider for these specific markers to get a true picture of your metabolic health: Fasting Insulin & Fasting Glucose (to calculate your HOMA-IR score). Lipid Panel (focusing on Triglycerides). Lipoprotein(a) & hs-CRP (markers of inflammation and genetic heart risk). Body Composition Analysis (to track muscle mass vs. visceral fat).About Ann:Ann Konkoly is a board-certified Nurse Practitioner, Certified Nurse Midwife, and Menopause Society Certified Practitioner. She is the founder and CEO of Kultivate Women's Health in Beachwood, Ohio, where she specializes in evidence-based hormone therapy, metabolic health, and medical weight management.Connect with Ann: Website: www.kultivatewomenshealth.com/about Instagram: www.instagram.com/annkonkoly.npConnect with Dr. Rachel Pope: Website: ourwomanity.comSocial Media: @drrachelpope

🧭 REBEL Rundown 🗝️ Key Points 💉 Hydrocortisone Saves Lives:The 2023 Cape Cod Trial (NEJM) showed a clear mortality benefit and reduced need for intubation in severe CAP patients treated with hydrocortisone.📊 Guidelines Are Catching Up:The SCCM (2024) and ERS now recommend steroids for severe CAP, while ATS/IDSA updates are still pending.🔥 Redefining “Severe”:Patients requiring high FiO₂ (>50%), noninvasive or mechanical ventilation, or PSI >130 meet criteria for steroid therapy — even outside the ICU.🍬 Main Risk = Hyperglycemia:Elevated glucose was the most consistent adverse effect, but rates of GI bleed and secondary infection were not increased.🧭 Early, Targeted Use Matters:Start hydrocortisone within 24 hours of identifying severity — especially in patients with high CRP (>150) or strong inflammatory response. Click here for Direct Download of the Podcast. 📝 Introduction Corticosteroids have long sparked debate in the treatment of bacterial pneumonia — once viewed with skepticism, now increasingly supported by high-quality evidence. In this episode, Dr. Alex Chapa joins the REBEL Core Cast team to explore how the 2023 Cape Cod Trial (NEJM) reshaped practice and guideline recommendations for severe community-acquired pneumonia (CAP). 📖 Historical Context & Long-Standing Skepticism For decades, the use of steroids in pneumonia was controversial.Early Use: Steroids entered practice in the 1940s and 50s for autoimmune inflammation, but there was immediate hesitation regarding secondary superinfections.Mixed Data: From the 1980s to the 2000s, small studies emerged on severe pneumonia and ARDS, but the data was inconsistent. Different trials used varying definitions of “severe” pneumonia and different C-reactive protein (CRP) cutoffs, making the data “spread” and easy to “cherry pick” to support or deny a benefit.Past Guidelines: This uncertainty was reflected in official guidelines:2007 (ATS/IDSA): The American Thoracic Society and the Infectious Diseases Society of America did not address the topic due to insufficient data.2019 (ATS/IDSA): Pre-COVID, the guidelines recommended against using corticosteroids in severe CAP. They acknowledged no benefit for non-severe pneumonia, but the data for severe pneumonia was considered too weak to endorse.Pre-Trial Consensus: Prior to 2023, the consensus was to avoid steroids in non-severe pneumonia, while severe pneumonia remained a “gray area” with no treatment showing a clear mortality difference. 📜 The Landmark Cape Cod Trial (NEJM 2023) The Cape Cod trial, published in the New England Journal of Medicine in 2023, reignited the discussion by providing robust, positive data.Trial Design: Phase 3, multi-center, double-blind, randomized, controlled trial.Intervention: 800 patients randomized to two groups, Hydrocortisone as a continuous infusion (200mg/day) versus a placebo infusion.Taper: On day 4, clinicians would decide whether to continue the infusion or begin a taper based on clinical response.Population: Patients with severe CAP, defined by meeting at least one of the following criteria:Pneumonia Severity Index (PSI) > 130.O2 by FiO2 ratio < 300.Need for mechanical or non-invasive ventilation (with PEEP ≥ 5).Need for high FiO2 (>50%) via non-rebreather or heated high flow.Primary Outcomes: Death for any cause 6.2% (hydrocortisone) vs 11.9% (placebo)Secondary outcomes:Death from any cause at 90 days 9.3% (hydrocortisone) vs 14.7% (placebo)Endotracheal intubation 18% (hydrocortisone) vs 29% (placebo)Hospital-acquired infections 9.8% (hydrocortisone) vs 11.1% (placebo)Gastrointestinal bleeding 2.3% (hydrocortisone) vs 3.3% (placebo)Vasopressor initiation by day 28 15.3% (hydrocortisone) vs 25.0% (placebo)Key Findings: The trial demonstrated superiority for hydrocortisone 📋 Updated Guidelines & Current Practice The Cape Cod trial, along with subsequent meta-analyses, has begun to change official recommendations.Society of Critical Care Medicine (SCCM): In 2024, an SCCM expert panel, reviewing the Cape Cod trial and 18 others, strongly recommended corticosteroids for severe CAP. They concluded that steroids reduce mortality and the need for mechanical ventilation.Meta-Analysis (Smit et al.): A 2024 meta-analysis in Lancet Respiratory confirmed the 30-day mortality benefit.European Respiratory Society (ERS): The ERS has issued a recommendation to use steroids for severe pneumonia but still urges caution regarding side effects.ATS/IDSA: As of the podcast recording, the ATS/IDSA had not yet updated their 2019 guidelines. 🛠️ Practical Application for Clinicians Defining “Severe” CAP: The key is to identify patients who qualify as “severe”. This can be done using:Scoring Tools: The PSI is the best validated tool for mortality but is cumbersome. Simpler tools like CURB-65 or SMART-COP are practical and acceptable for defining severity. 2023 meta-analysis from by Zaki et al showed both work well, but CURB-65 has better mortality prediction early on.Cape Cod Criteria: Any patient meeting the trial’s inclusion criteria (e.g., high-flow O2, non-invasive ventilation) qualifies, regardless of location (ED, floor, or ICU).Biomarkers: While not required, a CRP level was used in many studies. A CRP > 150 (Cape Cod) or > 204 (Smit meta-analysis) strongly indicates severe inflammation that would benefit from steroids.Clinical Judgment: A patient who looks “sick,” has “soft” blood pressure, or has dense infiltrates and high oxygen needs (e.g., >50% FiO2 on high flow) is a candidate.Adverse Effects:Hyperglycemia: This was the most significant risk identified, with rates between 6-12%. This is a primary concern, especially in patient populations with high BMI.GI Bleed & Secondary Infection: Fears of these side effects, which contributed to historical skepticism, were not borne out in the Cape Cod trial. The data does not support being overly concerned.Other Side Effects: Mood changes, delirium, insomnia, and agitation in the elderly are known side effects of steroids that were not specifically addressed in the trial but remain clinical concerns. 🔄 Clinical Pathway for Steroids in Severe CAP Unanswered Questions & Future Research Possible remaining questions:Biomarkers: Can we find a more precise CRP level to distinguish moderate from severe disease? Could other markers like ferritin or IL-6 be used? Dosing & Tapering: How much immunomodulation is needed, and when is it truly safe to taper?Gender Differences: Early data suggests females may respond better to steroids and experience fewer side effects. The question of female patients with severe CAP require less corticosteroids needs further exploration. 👉 Clinical Bottom Line The current literature, spearheaded by the Cape Cod trial, now supports the use of corticosteroids in severe community-acquired pneumonia. The best evidence currently points to hydrocortisone, started early (within 24 hours) after severity is identified using a validated tool. While hyperglycemia is a risk, the previous fears of GI bleeding and secondary infections were not substantiated in recent, rigorous trials. 📚 References Chapa-Rodriguez A, Abou-Elmagd T, O’Rear C, Narechania S. Do patients with severe community-acquired bacterial pneumonia benefit from systemic corticosteroids?. Cleve Clin J Med. 2025;92(10):600-604. PMID: 41033846Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;388(21):1931-1941. PMID: 36942789Chaudhuri D, Nei AM, Rochwerg B, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e233. PMID: 38240492 Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Alex Chapa, MD PGY 5 Pulmonary Critical Care Fellow Cape Fear Valley Medical Center Fayetteville NC 🔎 Your Deep-Dive Starts Here REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia Corticosteroids have long sparked debate in the treatment of bacterial ... Thoracic and Respiratory Read More The post REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia appeared first on REBEL EM - Emergency Medicine Blog.

Exclusive! We venture inside the Beltway to analyze the Sen. Lee land-sale debacle, look back on the victories, defeats and delays in law-making and public policy with our friends Jeff Crane (Pres./CEO) and Taylor Schmitz (Sr. VP - policy) of the Congressional Sportsmen's Foundation. That organization roams the halls of congress and all the alphabet agencies that restrict, protect and frustrate us, advocating on our behalf with legislative staff, elected officials and bureaucrats who make the rules. We'll look ahead, too, at some critical policy and legal opportunities including the chance for a new Farm Bill - the catchall legislation that funds CRP, among other programs. We'll also learn how plain old sportsmen and women can get involved at every level to ensure our voices are heard - and heeded. Insider editions are brought to you by CableGangz tie-out systems and Heartland Lodge, where you'll get special freebies and gifts for every booking (learn more here). [Take 10% off your next order at CableGangz.com with the promo code CG10.]

MANUAL DESCARGAR: https://drive.google.com/file/d/18-eu...Me pueden encontrar tambien en Instagram:   / medhacker  TikTok: https://www.tiktok.com/Compartan si me quieren apoyar! Gracias! ¿Qué es la creatina?-Descubierta en 1832, incluso antes que el ATP.-Es un compuesto nitrogenado que el cuerpo produce en hígado y cerebro.-Se obtiene en pequeñas cantidades de carne y pescado, pero es casi inexistente en dietas vegetarianas o veganas.-Funciona como "el Robin de Batman (ATP)": ayuda a regenerar rápidamente energía para contracciones musculares.Efectos principales en el músculo-Mejora fuerza y rendimiento: más repeticiones, mejor recuperación entre series.-Aumento de masa magra: en promedio 700 g de músculo en 6 semanas.-Recuperación: acelera la reparación muscular y disminuye daño.-Efectos en aeróbicos: ayuda en hidratación y reduce inflamación tras maratones o ironman.-No es un esteroide.Propiedades antiinflamatorias-Reduce citocinas inflamatorias (IL-6, TNF-α, CRP).-Tiene potencial en condiciones donde la inflamación es clave: envejecimiento, sarcopenia, enfermedades neurológicas.-Puede proteger al cerebro en situaciones de estrés metabólico (falta de sueño, jet lag, trauma).Cerebro y cognición-Beneficios en memoria, atención, depresión, Alzheimer, Parkinson y conmociones cerebrales.-Mejora síntomas de privación de sueño y fatiga mental.-En Alzheimer: 20 g/día por 8 semanas mostró mejoría cognitiva.-En depresión: 5 g/día junto con terapia o medicación ayudó a reducir síntomas.Salud ósea-En mujeres postmenopáusicas: 8–12 g/día redujo pérdida de densidad mineral ósea en cadera.-Puede actuar como anti-resortivo, parecido a los bifosfonatos.-Potencial para disminuir riesgo de fracturas y fragilidad.Mujeres, embarazo y niños-Mujeres: suelen tener menores reservas, responden bien a suplementación.-Embarazo: estudios en animales muestran beneficios en placenta y desarrollo fetal; ensayos clínicos en humanos están en curso.-Niños y adolescentes: dosis seguras (0.1 g/kg). Evidencia positiva en deportes y en casos de conmoción cerebral.Dosis y formas de uso-Estándar: 3–5 g/día.-Carga rápida: 20 g/día (divididos) por 5–7 días, luego 3–5 g/día.-Enfocado en cerebro: más de 10 g/día, incluso hasta 20 g en patologías como Alzheimer.-Se puede tomar con comida (mejor absorción con proteínas o carbohidratos).-No importa la hora: lo clave es la consistencia.Mitos y realidades-Daño renal: falso (creatinina puede subir, pero es marcador falso).-Hipertensión: no aumenta la presión arterial.-Retención de líquidos peligrosa: la hidratación es intracelular y benéfica.-Pérdida de cabello: no hay evidencia.-Engorda: al contrario, puede favorecer leve pérdida de grasa.-Necesidad de ciclo: no es necesario suspender.Seguridad-Considerado por la FDA como “Generally Recognized as Safe (GRAS)”.-Más de 1000 estudios respaldan su seguridad y eficacia.-Puede usarse en jóvenes, adultos, mujeres y mayores.Futuras áreas de investigación-Uso en cáncer, tanto en prevención como adyuvante en tratamientos.-Embarazo y lactancia: estudios en humanos en curso.-Trastornos neurológicos y psiquiátricos: depresión, ansiedad, PTSD, ADHD.Recomendaciones prácticas-Base de salud: ejercicio + sueño + buena nutrición.-Creatina es “la cereza del pastel”: segura, económica y altamente estudiada.-Idealmente acompañada de entrenamiento de fuerza y suficiente ingesta proteica.-En pacientes que usan GLP-1 (semaglutide, tirzepatide): fundamental para evitar pérdida de músculo.

Beat Heart Disease Before It Starts — Insights from Dr. Howard Elkin with Dr. Ben Weitz. Dr. Elkin's website is Heartwise.com.  His main office is in Whittier, California and he has a concierge practice in Santa Monica, California and his office number is 562-945-3753. What You'll Hear In This Episode: 02:40    A Functional Medicine approach looks at why the body would lay down plaque as a rational response to coat the artery wall against inflammation or oxidation or glycation reactions. 06:08    I asked Dr. Elkin what his view is on cholesterol and he mentioned that half of patients who have heart attacks have normal cholesterol 08:09    Dr. Elkin discusses the benefits of the Boston Heart Lab and other advanced lipid profiles for better assessing true CVD risk 09:36    Howard explains how small, dense particles are more likely to be oxidized and incorporated into arterial plaques 10:50     I explained how larger HDL particles perform reverse cholesterol transport to remove potentially harmful LDL particles from the blood stream 11:02     I asked how Dr. Elkin treats patients who have small, dense LDL particles and he explained that he gets his patients to change their lifestyle and he uses certain nutritional supplements such as niacin before he puts them on medications.   13:10     I asked Howard what are some of the most important dietary factors to change to lower cardiovascular risk in such a patient?  He said it's not about cutting our eggs and saturated fat, like we used to think.  Howard's way of thinking is that sugar not fat is the main villian, since it is pro-inflammatory. 16:57    I asked Dr. Elkin about one of his recent blog articles where he wrote about the new PCSK-9 inhibitor medications for cholesterol. Dr. Elkin explained these may be effective, but they showed that they could bring LDL cholesterol levels down to 36 and this is actually not a good thing, since you need cholesterol for hormones, vitamin D production, and brain function.   Also, these drugs cost $14,000 per year. 20:30   Howard explained that when he does places patients on statins, he always puts them on CoQ10 to prevent muscle problems. He usually uses 100-200 mg to start with.  With patients who have heart failure he will use very high dosages, along with magnesium, L-Carnitine, and D-Ribose. 24:22   Dr. Elkin discusses what nutritional supplements he will use to raise HDL levels: 2 tablespoons daily of Extra Virgin Olive oil,  coconut oil, low carb diet, exercise, weight reduction, and niacin. 27:52    I asked Howard how to lower Lp(a). He said that this fragment of LDL is extremely atherogenic and is highly likely to get oxidized. Niacin, estrogen, and fish oil can help. I mentioned that I also found that berberine and tocotrienols were also helpful. 30:30   We discussed what to do about patients with elevated CRP (indicative of inflammation). Dr. Elkin mentioned that this test should be done routinely on all patients, but it is often not measured.  There is a link between obesity and CRP and also between oral cavity problems and sinusitis and even poor sleep. He likes fish oil, turmeric, ginger, and boswellia to reduce inflammation.

Get Busy Living PodcastFIVE PRIMARY POINTS of the PODCASTChronic Inflammation is a Powerful Predictor of Disease and DeathDr. Mishra explains that mounting evidence—including a major American College of Cardiology scientific statement—shows inflammation, measured by high-sensitivity C-reactive protein (hsCRP), predicts long-term cardiovascular risk and mortality more strongly than LDL cholesterol alone. Inflammation is no longer a theoretical concern; it is clinically actionable and central to aging, heart disease, cancer, and dementia risk.Excess Inflammation Accelerates Aging and DiseaseWhile inflammation is essential for healing and fighting infection, chronic or excessive inflammation damages tissues and increases mortality risk. Dr. Mishra emphasizes that inflammation may be one of the best biological markers of aging, making immune balance—not suppression—a critical goal for long-term vitality.30-Day Anti-Inflammatory Challenge Targets the Essentials that Matter MostThe episode introduces a simple, actionable “execute on the essentials” framework:cut 200 calories per day, move 20 more minutes daily, sleep 20 more minutes nightly, and strengthen one in-person social connection each week. These small, disciplined changes can meaningfully lower inflammation and reduce disease and death risk without medications.Four Lifestyle Levers—Diet, Exercise, Sleep, and Connection Work SynergisticallyEating less and less often reduces inflammatory burden; regular aerobic and resistance exercise lowers CRP, IL-6, and TNF-α; adequate sleep both reduces inflammation and improves metabolic control; and social connection directly alters immune-related gene activity. Together, these four levers form a powerful, low-cost “anti-inflammatory quartet”Peak Vitality Requires Identifying Your Personal “Free Solo”Inspired by Alex Honnold's rope-free climb of Taipei 101, Dr. Mishra challenges listeners to define their own “Free Solo”—a deeply personal pursuit that demands long-term discipline, courage, and preparation. Pairing biological vitality (low inflammation) with meaningful purpose unlocks the highest levels of performance and fulfillment. Copyright VyVerse, LLC. All Rights Reserved. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit vitalityexplorers.substack.com/subscribe

Show notes: (0:00) Intro (0:49) Dr. Shah's background and personal health crisis (4:55) The most important biomarkers: hs-CRP, A1C, ApoB (7:46) How to track inflammation and metabolic health (13:00) Home tools: bioimpedance scale, grip strength meter (21:09) Nutrition basics: just cut ultra-processed foods (27:09) Hidden toxins in your air, water, and skincare (34:37) Longevity circuit: sauna, cryotherapy, hyperbaric oxygen (38:11) Therapeutic plasma exchange and next-gen biohacking (40:01) Dr. Shah's top 3 health tips anyone can start today (41:18) Where to find Dr. Shah (42:11) Outro Who is Dr. Darshan Shah?   Darshan Shah, MD is a health and wellness specialist, well-known, board-certified surgeon, published author, tech entrepreneur, and founder and CEO of Beautologie and Next Health. As an expert on all body systems, he has performed over 10,000 surgical procedures, including trauma surgery, general surgery and plastic/reconstructive procedures. As a health and wellness specialist, he has advised thousands of patients on how to optimize their well-being and extend their lifespan, culminating in the creation of Next Health, the first health optimization and longevity center to offer life-extending and enhancing technology and treatments in a beautiful, welcoming environment.   Connect with Dr. Shah Website: https://www.drshah.com/ LinkedIn: https://www.linkedin.com/in/darshanshahmd IG: https://www.instagram.com/darshanshahmd/   Grab your free Biomarker guide: https://www.drshah.com/biomarkers   Tune in: https://www.drshah.com/extend Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram

In this episode, James and Mark are joined by Matt Chouinard, Waterfowl Programs Director for Delta Waterfowl, for an in-depth discussion on current prairie wetland and grassland conditions. They explore how recent weather patterns and agricultural pressures are shaping duck nesting success across the Prairie Pothole Region.   Matt shares insights on the critical role of habitat for both nesting and brood-rearing, the value of conservation programs like CRP, and the importance of additional management strategies—including Delta's innovative Hen House program. The conversation also dives into the psychology of duck hunters, public perceptions of population trends, and the data-driven science behind conservation decisions. From habitat loss to hunter memories, this episode unpacks the complex relationships among agriculture, wetlands, waterfowl populations, and hunting success—highlighting why sustaining prairie ecosystems is essential for the future of waterfowl conservation.

Watch the FULL podcast here: https://youtu.be/qHFymGgsYyEWorried about Alzheimer's and what you can do now? You'll hear practical, testable steps to lower risk by targeting metabolism, inflammation and toxins, plus daily habits for brain rest and sleep. This clip explores the idea that Alzheimer's can have different drivers, the importance of early testing (continuous glucose monitors, hs-CRP, urine toxin tests), and simple changes like meditation, less phone time, better sleep, air purifiers, filtered water, non-toxic skin products, and eating organic while avoiding ultra-processed foods.***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.

Join Our Online Education Community "The School of Doza" Here: https://community.schoolofdoza.com/ In this podcast episode, Nurse Doza discusses the common complaint of fatigue and offers insights into its possible causes. He emphasizes the importance of addressing fatigue, as it should not be a daily occurrence. He also recommends getting blood tests, particularly one for DHEAS, to assess adrenal function and the body's response to stress. He mentions that chronic stress, lack of sleep, and unhealthy lifestyle habits can contribute to fatigue. Nurse Doza encourages listeners to prioritize self-care, including good sleep and stress management, to improve their energy levels and overall health.   TIMESTAMPS: 00:00 START 05:50 Adrenal issues can cause fatigue. 11:46 Inflammation and fatigue are connected. 16:34 Address underlying causes of fatigue. 22:08 Check homocysteine levels for fatigue. 27:43 Sugar and inflammation decrease ATP. 32:15 Adrenal support supplement is recommended.     Looking for a boost in energy and mood? Discover Zen, MSW's premium adrenal support supplement. Packed with natural ingredients, it aids in balancing your hormones and combating fatigue. Elevate your health and regain that lost zest for life.  Click here

In this special Metabolic Mailbag episode, cardiologist Dr. Bret Scher steps into the hot seat to answer your most pressing questions about ketogenic therapy, heart health, and metabolic markers. Drawing directly from listener questions, this conversation tackles the confusion and concern many people face when lab results change after starting a ketogenic diet.

In this episode of the Metabolic Freedom Podcast, Ben Azadi explains why turmeric is one of the most misunderstood anti-inflammatory tools and why most people never feel its benefits. Ben breaks down the science behind curcumin, the active compound in turmeric, and how it works with the body's natural intelligence to lower inflammation instead of masking pain like medications. You'll learn: Why over 90% of turmeric supplements fail due to poor absorption How curcumin lowers key inflammatory markers like CRP, TNF-alpha, and IL-6 What actually happens inside your body over a full 30-day turmeric protocol The biggest mistakes people make when taking turmeric How to choose the right turmeric supplement for real results The best timing and dosage to maximize absorption Why turmeric can support joint health, gut health, metabolic health, and recovery Ben also shares his personal story of overcoming chronic inflammation and joint pain, plus how turmeric has helped even his senior dog with arthritis. This episode is a must-listen if you're dealing with joint pain, stubborn inflammation, slow recovery, or want a natural way to support long-term metabolic health.

Most people assume they're being proactive about their health because they get an annual physical and a standard blood panel. A few numbers come back "normal," the doctor gives a thumbs-up, and that's the end of the conversation.  The problem is that those labs are often incomplete and disconnected from how people actually live, train, eat and recover. Many of the markers that matter most for long-term metabolic health and inflammation — like fasting insulin and high-sensitivity CRP — are routinely excluded. So what you're left with are numbers that often only flag problems once things are already far off track.  On top of that, testing once a year gives you no meaningful sense of trends, context, or direction. This episode looks at a more practical approach: identifying the biomarkers that actually reflect metabolic health, inflammation, hormonal balance and recovery, and finding ways to test them regularly without relying on one-off lab work.  It also addresses why timing, training load, and recent stress matter when you get blood drawn — and how ignoring those variables can lead to misleading results and unnecessary concern. The broader point is simple: meaningful blood work isn't just about collecting more data. It's about measuring the right things, testing often enough to see patterns, and interpreting results in the context of your lifestyle.  When you do that, blood work becomes a useful feedback tool instead of a once-a-year formality that tells you very little about where your health is actually headed. Learn more: What It Means to Be Metabolically Healthy [Blog Post]: https://michaelkummer.com/metabolic-health/ Affordable At-Home Blood Testing with SiPhox Health [Video]: https://youtu.be/R7qRLzBcp94  63: HbA1c Levels Explained: Why They May Be High Without High Blood Sugar: https://www.primalshiftpodcast.com/63-hba1c-levels-explained-why-they-may-be-high-without-high-blood-sugar/  Thank you to this episode's sponsor, OneSkin! What sold me was seeing real results. My wife started using OneSkin, and the improvement in her skin was obvious — not subtle, not hype. OneSkin products are built around their patented OS-01 peptide, developed from longevity research and tested for sensitive skin. Full review here: https://michaelkummer.com/health/oneskin-review/ For a limited time, get up to 30% off your first three subscription orders — no code required: https://oneskin.pxf.io/c/1289595/3445782/31050 In this episode: 00:00 Intro 02:19 The importance of comprehensive blood panels 05:36 Key biomarkers to monitor 09:43 Affordable and convenient blood testing options 18:03 Final thoughts Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code.  

She looked perfect on paper. Impeccable diet. Physically fit. Emotionally stable. Then she walked into my office and said, "I can't stop crying. I can't think. Something is wrong, and I don't know what it is." Her labs told part of the story: CRP at 87, neutrophils through the roof, lymphocytes bottomed out. But there was no fever. No illness. No obvious source. Until she dropped one sentence that changed everything. This is the first episode of my new Clinical Thinking series where I walk you through real patient cases, step by step, so you can see how I actually think through complex presentations. In this episode, you'll learn why the obvious answer is rarely the right one, how the 30/30/30 rule can keep you from tunnel vision, and what a cracked tooth taught me about dental history and emotional symptoms. I also share the exact protocol I used, and why I intentionally kept it simple instead of ordering more tests. If you want the framework behind how I approach every case, download The 6 Principles of Clinical Thinking. And if you're ready to develop this kind of thinking, not just follow protocols, join me inside Clinical Academy.  

There's no better time than now to set some new year's resolutions. In this episode, we are going to learn about how you,me, and really anyone can get involved in conservation. We'll learn about the Farm Bill and how it effects wildlife, wild habitat, and even hunting quality. We'll learn about conservation incentive programs like CRP and EQIP. Most importantly, we will learn how all of us can get involved and get some actual, tangible conservation in motion. Connect with Lake Pickle and MeatEater Lake Pickle on Instagram MeatEater on Instagram, Facebook, Twitter, YouTube, and YouTube Clips MeatEater Podcast Network on YouTubeSee omnystudio.com/listener for privacy information.

Modern anxiety isn't just emotional. It's chemical — and it's being triggered and sustained by the way we're living, consuming, and overstimulating ourselves every single day. In this powerful, personal episode, Elizabeth pulls back the curtain on what's really happening when we feel anxious for "no reason" — and shares the neurochemical truth about dopamine, oxytocin, cortisol, and inflammation. If you're constantly in your head, overwhelmed, overstimulated, or one step away from panic — this conversation will shift everything. You'll also hear the exact strategy Elizabeth is using to reclaim peace and presence in her everyday life — without deleting her business, becoming a monk, or pretending life isn't loud and full.

What if the gap between your age and your energy is wider than you think—and fixable? That's the wager we make as we sit down with longevity strategist Bob Gilpatrick to unpack why most people lose health, not just time, in their final decade and how to reverse that trend with measurable steps. We trace his journey from a near-fatal crash at 17 to a career spanning plant science roots, healthcare leadership, and breakthroughs that blend targeted nutrition with mind-body mastery.We get practical fast: CRP as a “burn rate” for your body, why keeping it below 0.5 changes everything, and how a complete nutrient strategy powers real mitochondrial energy instead of caffeine jitters. Bob explains epigenetic reprogramming—plant-derived, purified molecules that nudge gene sets for muscle, energy, NAD, and BDNF—plus why they can outperform complex peptide stacks at a fraction of the cost. He pairs these advances with essential building blocks: amino acids, enzymes, and minerals that allow your body to build what your genes request. The result? Faster strength gains, better motivation, and noticeable changes many feel within days.We also go beyond biology to the beliefs that block action. You'll hear how EFT tapping and havening calm the nervous system, reduce cravings, and resolve grief or fear by changing brain states in real time. From cartilage support that challenges “once it's gone, it's gone” to sustainable weight loss that protects muscle, this episode is a blueprint for adding strong, clear years—healthspan—to your life. If you're ready to test, adjust, and prove it in your own bloodwork and daily energy, this conversation gives you the steps and the science.Subscribe, share with a friend who needs a push, and leave a review telling us the one change you'll make this week. Then visit boomerboost.com for details and use promo code Omar at checkout.Join the What if it Did Work movement on FacebookGet the Book!www.omarmedrano.comwww.calendly.com/omarmedrano/15min

In this episode, Ben Azadi reveals the real reason arteries clog and it's not age, genetics, or cholesterol. The true driver of heart disease is chronic inflammation and metabolic dysfunction. Ben breaks down five science-backed drinks proven in human studies to reduce arterial plaque, lower inflammation, improve insulin sensitivity, boost nitric oxide, and support long-term cardiovascular health. You'll learn how simple ingredients like pomegranate juice, high-quality coffee, raw cacao, apple cider vinegar, and turmeric can dramatically improve markers like ApoB, CRP, triglycerides, fasting insulin, and blood pressure. Ben also explains how to rotate these drinks for maximum benefit, which options are best for keto or diabetes, and how quickly you can expect to see results in your lab work. This episode empowers you with practical, natural tools your doctor likely never mentioned, helping you take control of your metabolic and heart health starting today. FREE GUIDE: 5 Vegetables You Must Avoid To Lose Weight & Belly Fat   - https://bit.ly/3L6xMo0 

A new clinical analysis based on the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) found that older adults taking a daily cocoa extract supplement saw an 8.4% annual drop in high-sensitivity C-reactive protein (hs-CRP), a key marker of chronic inflammation The supplement provided 500 milligrams of cocoa flavanols daily, including 80 milligrams of (-)-epicatechin, which is the same bioactive compound found naturally in cacao Researchers said this anti-inflammatory effect may help explain a 27% lower risk of cardiovascular mortality previously observed in the larger COSMOS trial Taking a cocoa flavanol supplement appears to support vascular and immune health by calming NF-κB signaling and improving endothelial function Unlike dark chocolate, standardized cocoa extract supplements are free of sugar and fat, delivering clinically studied doses in capsule form

In this episode of the Birdshot Podcast, Nick Larson welcomes back Ted Koch, for an important conversation on prairie grouse conservation, grassland loss, ranching, and the future of upland habitat across North America. Ted also shares unforgettable elk-hunting stories, ruffed grouse parallels, and urgent insights into habitat fragmentation and the decline of gamebird populations. Ted Koch is a retired endangered species biologist and CEO of the North American Grouse Partnership. With decades of experience in western wildlife conservation, Ted works directly with ranchers, agencies, and conservation partners to protect prairie grouse species, including sharp-tailed grouse, greater prairie-chickens, lesser prairie-chickens, and sage-grouse. Expect to Learn Why prairie grouse populations are collapsing across North America How grassland loss and fragmentation impact sharptails, prairie-chickens, and sage-grouse Why ranching is essential to upland bird habitat How public-land and private-land management affect upland hunting access What hunters can do to support prairie conservation and rangeland stewardship Episode Breakdown with Timestamps [00:00:00] - Introduction [00:04:36] - What's keeping Ted Busy [00:19:20] - Storytelling, memory, and the hunt [00:20:42] - Introduction to the North American Grouse Partnership [00:25:18] - Private-land rangelands and public perception [00:37:05] - How Conservation Practices Create Real Value for Wildlife and Habitat [00:43:37] - Rangelands, Cattle Production and Food Output [00:56:12] - Comparing The Approach with CRP [01:00:50] - National Grasslands Conservation Act and Its Role in Farm Bill Funding [01:04:40] - Learn More about The North American Grouse Partnership and Membership Follow the Guest Ted Website: grousepartners.org  Facebook: https://www.facebook.com/GrousePartners  Instagram: https://www.instagram.com/na_grouse_partnership/?hl=en  Saving Ranching to Save Wildlife: https://www.youtube.com/watch?v=lxM6vvEoRgc Follow the Host Nick: Instagram: @birdshot.podcast Website: www.birdshotpodcast.com Listening Links: Spotify: https://open.spotify.com/show/17EVUDJPwR2iJggzhLYil7 Apple Podcasts: https://podcasts.apple.com/us/podcast/birdshot-podcast/id1288308609 YouTube: http://www.youtube.com/@birdshot.podcast SUPPORT | http://www.patreon.com/birdshot Use Promo Code | BSP20 to save 20% on https://www.onxmaps.com/hunt/app Use Promo Code | BS10 to save 10% on https://trulockchokes.com/ The Birdshot Podcast is Presented By: https://www.onxmaps.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (0:00) David Sinclair (0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of Aging; Epigenome & Genes (4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes (6:44) Physical Appearance & Aging (7:36) Sponsor: David (8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging (11:30) Rates of Puberty & Aging, Growth Hormone (12:37) Body Size & Longevity; Epigenetics (13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07) Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions (27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight Sleep (31:10) Iron & Senescent Cells; Personalize Medicine (32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic & Resistance Exercise (35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation (38:20) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices