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Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.An episode that does exactly what it says on the tin!You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross opens the Mailbag, following our big win over Leeds and ahead of the trip to Belle Vue...You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

Co-hosts Ryan Piansky, a patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Science Advisory Council, interview Dr. Claire Beveridge about EoE and dysphagia. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:49] Co-host Ryan Piansky introduces this episode, brought to you thanks to the support of Education Partners AstraZeneca, GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:17] Holly introduces today's topic, research on eosinophilic esophagitis (EoE) and dysphagia.   [1:24] Holly introduces and welcomes today's guest, Dr. Claire Beveridge, a gastroenterologist at the Cleveland Clinic. Dr. Beveridge heads the EoE Adult Clinic and the Transition from Pediatric to Adult EoE Clinic.   [1:36] Holly, a speech pathologist, says she is very excited to dive into the research Dr. Beveridge did with EoE and dysphagia. Holly asks Dr. Beveridge to share some of her background.   [1:48] Dr. Beveridge was recruited to the Cleveland Clinic about five years ago to head the EoE Center. She loves the work they have done there.   [1:57] Dr. Beveridge says it's been nice to center everything on their EoE patients and have multidisciplinary care with speech-language pathologists, allergists, dietitians, pulmonologists, and more. It's been a great experience.   [2:15] Dr. Beveridge says the other thing they are really proud of is having a Transition Clinic. It can be tough for patients to transition from pediatric to adult care.   [2:23] Dr. Beveridge says this is something she was inspired to do when she was finishing her training at the University of Pennsylvania, where they had been doing some of that. It was really important to her when she joined Cleveland Clinic.   [2:34] Dr. Beveridge, with her Co-director, Dr. Sophia Patel, helps patients transition from pediatric to adult care.   [2:41] Holly speaks of the challenge of transitioning from pediatric care at a multidisciplinary clinic to adult care.   [3:08] Dr. Beveridge says you can't do any training at Northwestern without loving the esophagus. She did her residency there, got exposed to esophagology, and got to know Dr. Gonsalves and Dr. Hirano really well.   [3:33] Drs. Gonsalves and Hirano are really big names in EoE. Dr. Beveridge was fascinated by the disease. She loved the patients and wanted to help them and make them feel better. It's a burgeoning field.   [3:48] Dr. Beveridge says that it's only in the last few years that we have had FDA-approved medications for it, and that we have been jerry-rigging asthma medications to treat our patients.   [4:03] Dr. Beveridge says it's really exciting to see the treatment options we can offer.   [4:10] Ryan says it's exciting to see how EoE management has changed.   [4:16] Ryan says we see so many patients who are untreated or poorly treated for years, who have restructuring of their esophagus and present with dysphagia, or have strictures and rings leading to food impactions; the long-term effects of untreated EoE.   [4:34] Ryan says it's exciting that now we do have better treatment options for people, right off the bat.   [4:43] Dr. Beveridge conducted some research on EoE and dysphagia and presented a poster at the 2024 Digestive Diseases Week.   [4:51] The poster was titled, "Esophageal Luminal Diameter is Associated with Dysphagia and Eosinophilic Esophagitis: Implications for Endoscopic Dilation Therapy."   [5:11] Dr. Beveridge says dysphagia means issues with swallowing. It's a feeling of something getting stuck or something slowly moving down. There are also subtle symptoms that can happen.   [5:31] Dr. Beveridge says patients who have had EoE for a long time become accustomed to how they swallow. Things a patient may think are normal, like needing water and taking a sip after each bite, are learned accommodating behaviors.   [5:58] Dr. Beveridge says accommodating behaviors are that you're needing to imbibe extra water, you're modifying how you're eating, extra chewing, avoiding pills, avoiding other certain foods, and things like that that can be modifying factors.   [6:19] So, difficulty with swallowing, things getting stuck, slowly moving down, but also keeping in mind some of those modifying behaviors that we may end up using.   [7:23] Dr. Beveridge says her motivation was seeing patients in her clinic who were having persistent symptoms, and getting them into histological remission. The goal of treating your EoE is to get the eosinophils less than 15; close to zero is great.   [7:45] Dr. Beveridge says we have patients who, despite doing their endoscopies and taking biopsies, things look fine; they're still having issues with swallowing. Why is that the case?   [7:58] Dr. Beveridge says in a different research paper she had done, looking at some of the predictors for that, one of them was fibrostenosis. There are also other things that can contribute, like esophageal hypervigilance and a fear of swallowing.   [8:21] If a patient has had a food impaction, it's going to be scary to try to swallow again. Some of it is behavioral, but some of it is structural. At what luminal diameter (the size of the esophagus) is that causing a clinical problem for patients?   [8:45] A normal esophagus is 20 to 24 mm in diameter. Traditionally, around 14 to 16 mm in diameter has been when we say that patients get symptoms or they're feeling the issues with swallowing.   [9:03] Dr. Beveridge says a lot of those studies have never been done specifically for EoE patients.   [9:08] Dr. Beveridge wanted to know, if we exclude cancer, if we exclude acid reflux, and all of these other things, and just look at our EoE patients, what size of the esophagus are we looking at?   [9:20] Dr. Beveridge explained they specifically looked at patients whose histology was under control and then compared those who continued to experience symptoms with those who did not. The goal was to determine the histologic threshold at which patients begin to experience dysphagia.    [9:54] Dr. Beveridge says they saw this threshold at 16 mm (1.6 cm). That's still quite the difference from a normal esophagus of 20 to 24.   [10:08] Dr. Beveridge says our esophagus can definitely handle being smaller, but then, once you get to that 16 mm, for a lot of patients, it really does cause that feeling of things getting stuck or slowly moving down.   [10:20] Holly says what's cool about the retrospective data Dr. Beveridge looked at, and the parameters she placed in the research, is that when a patient goes in for an endoscopy, the doctor can measure and say maybe this is why dysphagia is going on.   [10:48] Holly finds that adult patients with food impactions are scared to eat the same food again. She loves having this data to share with patients and say, let's look at what your esophagus measures at. Let's do a smaller bite. Let's add a dip and liquid.   [11:12] Holly says data can push so much progress. Holly, having multiple chronic illnesses, loves when doctors can say, this is going to be safe. This is the mode that we're going to go with.   [11:30] Dr. Beveridge says in the retrospective study, they were looking at stuff that had already been done. We decided from here to assess patients more prospectively. All of this was based on chart review from when the note said symptoms or no symptoms.   [11:53] Dr. Beveridge says when she started this EoE clinic at the Cleveland Clinic, part of it was to standardize better how we were collecting data from patients to understand their symptoms.   [12:07] Dr. Beveridge has a standardized questionnaire for patients to understand if they are having heartburn and difficulty with swallowing, so she can know that at each point of their endoscopy.   [12:18] Dr. Beveridge says it will be nice, hopefully in the future, when she can give a little more detail and depth in terms of assessing this more prospectively and seeing if that same number holds up or if she needs to tweak it a little bit.   [12:34] Holly thinks it's fascinating. Numbers give us so much information, to know if my mm is this versus this, the next time, or during allergy season or not.   [12:53] Ryan says it's cool that you're able to look back at existing patient records and identify this information. Now we have that 16 mm number in mind to say maybe this is where we'll start to see increased risk of dysphagia in these patients.   [13:28] Dr. Beveridge says, how we had to do it retrospectively was based on the endoscopist estimating what the size is. Gastroenterologists recognize they're not always the best at estimating the size of the esophagus.   [13:50] Dr. Beveridge says, if your endoscope could not pass through, or it was snugly passing through, you know the diameter of the endoscope. If a dilation was done, at what size dilation do we start to see a disruption?   [14:19] Dr. Beveridge says, the goal of a dilation is to get a disruption because there's scar tissue we want to break open. A patient might think disruption means a perforation or something more scary, but that is the goal. We want to break open that scar tissue.   [14:42] Dr. Beveridge says, once we see that scar tissue break open a little bit, then we can estimate what the diameter is, based on the size dilator we used.   [15:10] Dr. Beveridge says for adults, we use a standard adult upper endoscope, and that's about 13 mm. The ones we use for kids are about 6 mm.   [15:35] Dr. Beveridge says the adult endoscope is around 13 mm, and it's around 14 to 16 mm when we start to see the symptoms.   [16:07] Dr. Beveridge says there are two main types of dilation that we do. One is the Savary dilator or wire-guided dilator, a long dilator that stretches the entire esophagus, from the mouth down to the stomach.   [17:20] Dr. Beveridge says another way of doing it is while you have the endoscope in, you thread a catheter. At the end of the endoscope, there's a balloon. You fill the balloon with saline up to different sizes. Typically, they go up by 3 mm, so 12 to 15 mm.   [18:01] Dr. Beveridge says the catheter balloon dilator is good for discrete strictures because the balloon isn't going to do the entire esophagus; it's just going to do one area of the esophagus, and you're watching it the whole time.   [18:19] For the wire dilator, you remove the scope. You're not able to see, so it's important to assess ahead of time how narrow things are, so you start at a safe dilation. You go in each time to see if there's starting to be disruption, and then you can do more.   [18:44] Holly asks if a gastroenterologist doing an upper endoscopy with sedation sees that it's tight, would the gastroenterologist automatically do a dilation? Or, can a patient with dysphagia symptoms request to have a dilation?   [19:28] Dr. Beveridge says, right before an endoscopy, she discusses it with the patient and gets consent. She asks, even if their symptoms are good, but in the endoscopy she sees a narrowing where she would recommend a dilation, if they're OK with that.   [20:05] Dr. Beveridge says, if they're having issues with swallowing, often she will ask if they're OK with her doing a dilation. If she sees a narrowing, she can focus on that area and dilate it.   [20:19] Dr. Beveridge says not everywhere in the esophagus can we see as well. The very beginning of the esophagus is challenging to see and challenging to evaluate on imaging.   [20:32] Dr. Beveridge talks about empiric dilation. You don't see a narrowing, but you want to rule it out, so you do a dilation at a safe size, like 16 or 18 mm, to make sure you're not missing something up high.   [20:58] Dr. Beveridge says she always talks about that with her patients. Most say, go ahead. Some patients definitely want dilation; other patients say no, they really don't.   [21:12] Dr. Beveridge then asks the patient if there's real narrowing that may cause a food impaction, would they want dilation then, or hold off for another day?   [21:30] Dr. Beveridge never wants to do something the patient is not comfortable with. She also doesn't want them to need another endoscopy unnecessarily, if she can avoid that for them in the moment.   [21:46] Dr. Beveridge mentions the BougieCap used in Europe. It's a cap you put at the end of the endoscope. You use your endoscope as the dilator. You watch the whole time. It is hard plastic that causes a nice dilation. We may see it come to the U.S.   [22:37] Dr. Beveridge speaks of the FLIP catheter, which is a catheter with a balloon that doesn't cause dilation but distends and helps measure the diameter.   [23:33] Holly asks if Dr. Beveridge gives tips to patients on how to prepare for dilation and the recovery process.   [23:49] Dr. Beveridge had an upper endoscopy. She says there's nothing like experience to understand it better. She didn't have a dilation, but the biopsies caused discomfort.    [24:21] Dr. Beveridge says a lot of her patients have been through upper endoscopies, so they know how it feels. She warns them that the biopsies and dilation can cause discomfort.   [24:33] What's challenging is that everyone is different. Some patients are going to be more hypersensitive to it, and other patients are going to say they felt nothing and they were fine.   [24:46] Dr. Beveridge says some patients need to modify their diet for a few days to avoid significant chest pain. You never want someone to have to go to the ER for significant chest pain when it will just heal over time, and there's no perforation.   [25:12] Dr. Beveridge says other patients will be like her, eating chips and pretzels and saying they're fine. Dr. Beveridge typically has them start with liquids, nothing too hot or too cold, and advance as tolerated.   [25:28] Dr. Beveridge says patients can always use TylenolⓇ and over-the-counter numbing agents. You'll still have patients who will get significant discomfort. For the most part, starting with liquids has worked for Dr. Beveridge's patients.   [25:44] Holly recommends over-the-counter when her patients call, after she talks to their GI. Holly says after she has an endoscopy, she starts on liquids and shakes. On day three, she's fine. Holly says individualized care is amazing. We all are different.   [26:14] In the pediatric setting, the parents get the counseling, and they have not had sedation, but on the adult side, you're talking with the patient, who had sedation. Sometimes they don't remember.   [26:40] Dr. Beveridge says when possible, she waits for family members to come back and tells them they're going to have to "be the memory" because the patient probably won't remember this conversation.   [26:55] If a patient says no, they don't want them to come back and hear about it, always respect that. But Dr. Beveridge always tells them, you may not remember what we say.   [27:30] Ryan asks about data on how many times someone may need dilations. Dr. Beveridge says it comes down to the patient, but the biggest issue can be uncontrolled inflammation.   [27:44] Dr. Beveridge says if a patient's EoE is not controlled, inflammation leads to continued scarring down. That's why we talk about dilation as being an adjunctive measure, but not a treatment for EoE. It doesn't do anything for the inflammation.   [28:03] Dr. Beveridge says she has patients who ask why she can't just do a dilation every now and then. Dr. Beveridge considers dilation to be safe when needed, but if you can avoid it, that would be nicer for everyone.   [28:21] Dr. Beveridge says there's no great data on whether you only need one, or whether you're going to need 10, but one big theme is just: have we gotten your inflammation under control? That's also true for other conditions, such as acid reflux.   [28:45] Holly wasn't diagnosed until she was in her mid-twenties, and she had several upper endoscopies as a teenager and college student to dilate her, to help the situation.   [29:17] Holly says she had to get more endoscopies to figure out her weird food triggers that are not typical for everybody, so even if she's treated, she still has inflammation. That's why she had so many upper endoscopies.   [29:30] Ryan talks about underlying issues causing inflammation. Dilation is not treating those underlying causes. It's just helping with one symptom of this dysphagia, by expanding the esophagus.   [29:50] Ryan asks, What changes in symptoms should patients expect after the dilation? Dr. Beveridge says, ideally, if there's been a stricture, you're going to start to feel like your swallowing is better. You can get pills and food down better.   [30:07] Dr. Beveridge says, immediately post-dilation, sometimes people feel a little bit worse. Everything you swallow may be uncomfortable for you. But if it's been a successful dilation, hopefully, you're going to feel that things are going down better.   [30:40] Holly says she is so grateful that Dr. Beveridge looked into this, and hopefully, there will be a new protocol in the future. Holly asks what other key takeaways from this research may interest Dr. Beveridge in researching something further.   [31:02] Dr. Beveridge says, making sure that we're not missing scar tissue is big and important. One thing that we're trying to look at with our Pediatric GI colleagues is what threshold we should be looking at for the pediatric patient population.   [31:19] Dr. Beveridge says a pediatric patient's esophagus is a different size than an adult patient's. Understandably, we are more cautious when doing a dilation in the pediatric patient population than we are with adults.   [31:34] Dr. Beveridge may recommend empiric dilation for an adult but will feel more cautious about that with pediatric patients than with adult patients. Understanding what that threshold should be for the pediatrics is going to be really interesting.   [31:57] Dr. Beveridge says the diameter threshold we discussed is going to be important to know about, but everyone is different. You may have a diameter of 14 mm, you feel fine, and you don't want a dilation; you can accommodate OK. That's reasonable.   [32:15] Dr. Beveridge says she has had patients who get up to 18 mm, and that helps them, but they need a little bit more. If someone needs more of a dilation, we do that. Yes, have a threshold to assess, but always assess for what's personal for your patient.   [33:04] Dr. Beveridge says not just to assess the luminal diameter, but a thing that is helpful for gastroenterologists to know will be if there are other factors at play. As in her study of dysphagia predictors, anxiety, depression, and hypervigilance can play roles.   [33:37] Dr. Beveridge has patients who have to have a critical narrowing for them to finally feel an issue. Other patients, if they have the slightest of narrowing, are feeling something. Some patients are just more vigilant of what's happening in their esophagus.   [34:07] Dr. Beveridge says there's definitely a role for asking if your anxiety is under control. If there's feedback in the nerves, should we ask your GI Psychologist to be involved in terms of CBT for your esophagus? Take a look at everything.   [34:27] Dr. Beveridge says another part of the study they looked at was: are there different thresholds of eosinophils that we should be looking at? Is it just less than 15, or do some patients need it to be lower? Less than six? Less than 10?   [34:43] Dr. Beveridge says look at it as a whole for your patient.   [34:53] Dr. Beveridge says next, she will be working on a very long-term project: Can we identify a non-invasive method of screening a patient, diagnosing a patient for EoE, or monitoring a response to therapy?   [35:13] Dr. Beveridge has looked at transnasal endoscopy, which is put into this category of minimally invasive. It's still invasive; you're putting a scope through someone's nose, but it doesn't require sedation, which is a nice thing for some patients.   [35:29] There's the EnteroTrack, which started in Colorado. A patient swallows a string, and it stays in their esophagus for an hour, and we look at the proteins to see if things are active or not active.   [35:45] Dr. Beveridge is also looking at the breath metabolome. If we breathe into a bag and take a look at all the volatile organic compounds that are in our breath, can we find a signature related to EoE?   [36:01] It's assessing about 100 different compounds, not looking at one in particular, but how the whole thing looks. What signature is there, based on looking at all the compounds?   [36:15] Dr. Beveridge presented some of that data at DDW and has a grant from the ACG to look at this and assess patients with and without EoE.   [36:33] Dr. Beveridge says further, doing longitudinal data of looking at patients once they've gotten into remission on treatment and seeing, do we then see a signature change?   [36:47] Dr. Beveridge says no one is under any illusion that endoscopies are going away. They will always be part of what we do in gastroenterology, but there are limitations: sedation, a full day away from work, nothing by mouth, and a driver, etc.   [37:04] If there are alternatives to help supplement that, it would be nice. One of the barriers for patients doing diet elimination is the number of endoscopies that are required. If there's a way to assess by breath if a food is a trigger, that would be good.   [37:32] Dr. Beveridge says that's the big thing she's looking at, but it will take years. It's not going to be a quick, easy one, but it's very interesting to take a look at.   [37:45] Holly speaks of how much treatment has changed since she was diagnosed. She has done all the scopes. She says this sounds amazing. She loves that people like Dr. Beveridge are thinking of how to make testing less invasive and more comfortable.   [38:12] Dr. Beveridge says another thing she is excited about is the transition of care. She recently did a survey and is analyzing the data to assess what the barrier is from the physician perspective in terms of helping our patients transition.   [38:40] Dr. Beveridge is also looking at doing a nice multi-center consensus to help this as well, led by Dr. Sophia Patel and Dr. Emily McGowan, who are fantastic in the EoE world, looking to see how we can make this better for our patients.   [38:58] Ryan says, with so much interesting work coming up, we'll have to have you back to chat about some of these additional projects. Everyone is super interested in less invasive stuff and better treatment pathways. Transition of care is an important part of that.   [39:11] Ryan appreciates Dr. Beveridge for joining the conversation and hopes to have her back on another episode so we can learn more about EoE and these different future research endeavors.   [39:20] For our listeners who would like to learn more about EoE today, you can visit apfed.org/EoE and check out the links in the show notes below. [39:27] If you're looking to find specialists who treat eosinophilic disorders, we encourage you to use APFED's Specialist Finder, available at apfed.org/specialist.   [39:36] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [39:46] If you have personally been impacted by eosinophilic disorders and are interested in sharing your experience, please check out apfed.org/shareyourstory.   [39:55] Ryan thanks Dr. Beveridge for joining us. This was a fun conversation and really insightful. Holly thanks APFED's Education Partners AstraZeneca, GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode:   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.orgapfed.org/specialist apfed.org/connections Claire Beveridge, MD Cleveland Clinic Education Partners: This episode of APFED's podcast is brought to you thanks to the support of AstraZeneca, GSK, Sanofi, Regeneron, and Takeda.   Tweetables (Edited):   "I have loved the work that we've done [at the Cleveland Clinic]. It's been really nice to center everything on our EoE patients and have nice multidisciplinary care with speech-language pathologists, allergists, dietitians, pulmonologists, and everyone." — Claire Beveridge, MD   "It's a little crazy to think that it's only in the last few years that we have had FDA-approved medications for [EoE], and that we have been jerry-rigging asthma medications to treat our patients." — Claire Beveridge, MD   "On the whole, dysphagia means issues with swallowing. … It's a feeling of something getting stuck or something slowly moving down. There are also subtle symptoms that can happen." — Claire Beveridge, MD   "The goal of a dilation is to get a disruption because there's scar tissue we want to break open." — Claire Beveridge, MD   "I am looking at the breath metabolome. If we breathe into a bag and take a look at all the volatile organic compounds that are in our breath, can we find a signature related to EoE?" — Claire Beveridge, MD   Guest Bio: Claire Beveridge, MD, is a Staff Member in the Department of Gastroenterology and Hepatology and heads the Eosinophilic Esophagitis (EoE) adult clinic as well as the transition pediatric to adult EoE clinic. Dr. Beveridge's specialty interests include: EoE, Achalasia, Barrett's esophagus, GERD, esophageal swallowing disorders, and esophageal motility disorders.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross is joined by Castleford Tigers Chairman Martin Jepson & Dean Jones, the newest member of the Tigers' Board of Directors!You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a nanoparticle vaccine showed potential to protect from a 'tripledemic'. Elsewhere, could 'magic mushrooms' treat anorexia? You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross reflects on a brutal day at Magic Weekend and what's next, as we await the trip to Leigh...You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, experts warned patients were being denied access to personalised cancer care. Cancer research was a theme elsewhere, with findings emerging from studies into a CAR T-cell therapy, lung cancer and breast cancer.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

In this episode, Pablo Janowicz, global key account manager from Dairy Data Warehouse, explores how technology is helping transform the dairy industry through data and artificial intelligence (AI). We discuss the challenges of accessing farm data, the innovative technology that makes data collection simple and automated, and the rigorous quality processes required to ensure data is accurate, standardized, and ready for analysis. We also dive into how data points from millions of cows are used to power machine learning models that help dairy professionals make smarter, data-driven decisions. Whether you're interested in dairy technology, AI, or the future of dairy farming, this episode provides valuable insights into how data is driving innovation across the industry. This episode is sponsored by Dairy Data Warehouse. At Dairy Data Warehouse (DDW), we unlock the full potential of data on dairy farms across the globe to enable the industry to harness big data and AI for sustainable and more profitable farming. DDW collects farm data from the herd management software and other sources on farm. We ensure high data quality by cleaning and transforming it into a unified, comparable set for AI driven strategic decision-making, benchmarking and insights. Our solutions support key stakeholders in nutrition, genetics, animal health, cow monitoring, and milking equipment. Let's connect to explore how data can drive your business forward. 

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross opens the mailbag ahead of the 2026 Magic WeekendYou can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, researchers uncovered clues explaining risks of heart disease, lung disease, Covid-19 and cancer. Elsewhere, find out what is included in the latest issue of DDW. You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross chats to Glyn Jepson about his fantastic Centenary Walk challenge, before turning his attention to the rumour mill and the upcoming visit of the York Knights...You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, results showed the new Wegovy pill could help patients lose 17% of their body weight. Elsewhere, advances were made in both cancer treatment and cancer research.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Send us Fan MailThe possible role of deuterium (heavy isotope of hydrogen) in regulating cell division, mitochondrial metabolism & cancer.TOPICS DISCUSSED:Deuterium Basics: Deuterium is twice as massive as regular hydrogen; natural water contains ~150 ppm, with stronger oxygen-deuterium bonds slowing reactions compared to oxygen-hydrogen.Mitochondrial Role: Healthy mitochondria produce deuterium-depleted metabolic water (~110 ppm from fat oxidation vs. ~150 ppm from carbs), helping maintain low cellular D:H ratios.Cell Growth Regulation: Lower deuterium slows cell division in vitro; cells sense small D:H changes, with higher levels (near/above 150 ppm) promoting growth.In Vitro Evidence: DDW (e.g., 25-125 ppm) can reduce proliferation and alters cancer-related gene expression.Animal Models: DDW caused tumor regression in mice with transplanted human cancers and showed possible efficacy in veterinary use for dogs and cats.Human Prostate Cancer: Phase 2 randomized study showed greater Prostate-Specific Antigen (PSA) reduction, tumor shrinkage, and better 1-year survival with DDW plus standard therapy vs. placebo.Dietary Modulation: Ketogenic/high-fat diets lower body deuterium from lipid oxidation.Broader Implications: Potential in neurodegeneration models; larger trials needed for registration as adjunct cancer therapy.ABOUT THE GUEST: Gábor Somlyai, PhD is a molecular biologist who pioneered deuterium depletion studies at the National Institute of Oncology in Hungary. His primary work focuses on the role of deuterium in living organisms and the development of deuterium-depleted water for cancer therapy.Support the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross gives his reaction to the Jason Qareqare re-signing before opening the Mailbag! Plus, the first instalment of the CTSC Team of the Century!You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, new research showed anti-IL-1β drugs could prevent lung cancer. Elsewhere, the UK is set to benefit from specialised blood tests and funding for early-career researchers.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross opens the Mailbag, leading to a fun Cas challenge, Tyrell Sloan discussion and a look at the Catalans challenge posed in Perpignan.You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a cancer drug demonstrated it could reduce tumours by as much as 55%. Elsewhere, AI was a recurrent theme in both clinical trials and drug development.   You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross pays tribute to a true Rugby League legend, opens a stacked Mailbag and looks ahead to the visit of the Leigh LeopardsYou can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a UK group accelerated efforts to develop a vaccine for Ebolavirus. Elsewhere, significant findings in colorectal and brain cancer could shape future cancer treatments.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross reacts to Brett Delaney's departure, the end of Brad Singleton's Tigers stint and the reports around Jason Qareqare's futureYou can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a report showed patients in Europe face barriers to patient access. Elsewhere, Wellcome prizes are facilitating research in both tropical disease and mental health.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Ross reacts to the reports that Jack Brown is on his way to the club before opening a HEAVING mailbag!You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, research uncovered new treatment pathways for hard to treat breast cancers. Elsewhere, therapies given the green light could combat type 2 diabetes and generalised myasthenia gravis.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Arron Moss joins the pod to discuss the Tigers' first third of the season, the major Cook signing and his work with the England Fire & Rescue team!You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, the FDA advanced an initiative to implement real-time clinical trials. Elsewhere, UCB made headlines through an acquisition and its cancer research venture.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.Reaction to the reports down under that Damien Cook is signing for the Castleford Tigers from 2027...You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

Welcome back to The COYFCast, brought to you by the Castleford Tigers Supporters Club! This episode is sponsored by DDW Air Conditioning. For a free quote, contact DDW at dan@ddwac.co.uk or 07399 547669.The Mailbag is open - and live reaction to Krystian Mapapalangi's contract extension!You can now support Ross and the podcast by joining our Patreon membership service here: https://www.patreon.com/COYFCastIf you simply want to show your support, you can became a COYFer for £3 per month. You can also unlock early access to each and every episode by becoming a Premium COYFer, for £4.50 per month.Follow The COYFCast on social media:Twitter: @COYFCastFacebook: The COYFCastInstagram: @coyfcastTikTok: @COYFCastContact the podcast: coyfcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, the UK made headlines for both the investment it has attracted and the clinical trial reforms it rolled out. Elsewhere, the world's first antimalarial drug for newborns could soon address a critical unmet need.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, an obesity drug proved it could improve liver health independent of weight loss. Elsewhere, Lilly was back in the news for both its type 2 diabetes drug and the company's latest acquisition.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, key breakthroughs emerged in cancer research. Elsewhere, regulatory reforms have accelerated clinical trial set up in the UK.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, researchers discovered how genetic mutations cause a previously unknown recessive condition. Elsewhere, Eli Lilly made the headlines for both an approved drug and a drug collaboration.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, there were crucial developments in neuroscience drug discovery. Elsewhere, a new treatment for platinum-resistant epithelial ovarian cancer has been approved in the US. You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates the key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a study found obesity could be treated in other ways than through drugs suppressing appetite. Elsewhere, prostate cancer was a central theme in cancer research.   You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates the key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a cancer enzyme discovery provided clues for potential new treatments. Elsewhere, how can your recycled plastic bottles be made into Parkinson's drugs? You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, research on the brain proved a popular theme, unlocking insights into Alzheimer's, dementia and cancer. Elsewhere, a genetic target could provide new routes to breast cancer treatment.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, figures showed the number of women in biotech leadership has stalled. Elsewhere, could your diet make cancer therapy more effective? You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, more effective treatments were found for both HIV and chronic wounds. Elsewhere, €40,000 is up for grabs in prostate cancer research.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, researchers found an unexpected drug could help treat depression. Elsewhere, a new company is set to advance a cerebral palsy therapy.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, researchers made a key discovery into cancer survival. Elsewhere, a global research effort into kidney disease is underway.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, innovative therapies showed the way to more effective cancer treatments. Elsewhere, how can brain function be improved in Alzheimer's patients?  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW podcast is available to listen to below. This week, Bruno Quinney speaks to DDW Editor Reece Armstrong and Senior Digital Content Editor Diana Turner to look ahead to the world of drug discovery, pharma and biotech in 2026. They explore why AI will continue to dominate in 2026, why obesity and breast cancer will attract investor attention, and how drug discovery will look to resolve the challenges of clinical trials. You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week's discoveries into Parkinson's disease, allergies and common cancers could shape drug development. Elsewhere, why is the UK leading Europe's biotech market? You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.    

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, an innovative therapy showed encouraging results in tackling melanoma. Elsewhere, why is a former American football player getting involved with a biopharmaceutical company? You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, new research in women's health uncovered significant findings related to endometriosis and ovarian cancer. Elsewhere, can ageing be reversed?  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a new report found breast cancer was the world's most studied disease for the fifth year running. That same report predicted obesity to break into the top five, with weight loss a key theme across other headlines last week.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.

The latest episode of the DDW Highlights Podcast is now available to listen to below. DDW's Bruno Quinney narrates five key stories of the previous week to keep DDW subscribers up-to-date on the latest industry news. Last week, a research team found that a hidden molecular switch fuels obesity. Elsewhere, AI-generated antibodies have been tolerated by human immune cells.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.      

In this week's episode of The Energy Code, Dr. Mike Belkowski takes listeners on a fascinating deep-dive into the origins, science, and cutting-edge clinical research behind deuterium-depleted water (DDW) — specifically Litewater, the most depleted DDW on the planet at just 10 ppm.   Drawing from a decades-long historical arc, from the Big Bang to Soviet gerontology labs to modern mitochondrial biochemistry, Dr. Mike breaks down how deuterium impacts ATP production, aging, longevity, cancer metabolism, and cellular repair. He also explains why deuterium depletion may be one of the strongest yet overlooked tools for increasing mitochondrial function and long-term resilience.   Listeners also get a rare behind-the-scenes look at Victor Sagalovsky's A Brief History of Deuterium-Depleted Water and the scientific breakthroughs that shaped the modern DDW field. Dr. Mike shares how BioLight's updated BioBlue formulas now use 100% Litewater, and why lowering deuterium levels below 120 ppm may be a cornerstone of anti-aging protocols. In This Episode, Dr. Belkowski Covers:  

Want to reach out to us? Want to leave a comment or review? Want to give us a suggestion or berate Anthony? Send us a text by clicking this link!A microphone squeal, a sarcastic wine ad, and then the floor drops out. We go from laughs to the fault lines running through Catholic life right now: a made-for-camera stunt at an ICE facility framed as “Eucharist denied,” diocesan letters pushing Latin Mass communities to fold into “reverent” alternatives, and families who built their lives around stable liturgy wondering where to go this Sunday. We don't dress it up—trust breaks when sacraments and headlines get blended for optics.We walk through Knoxville's announcement, the signals from Rome's DDW, and what the first week's numbers look like when a thriving TLM map gets redrawn. Behind every statistic is a home sale, a homeschool co-op, and a seven-year-old who just lost the friends he prays with. We press the claim that liturgy forms people: habits at the altar shape what your conscience tolerates on Monday. That doesn't deny validity; it insists that culture matters and that “reverent Novus Ordo” promises feel thin when the same authorities hint they'll remove kneelers if challenged.Cardinal Robert Sarah's voice serves as a compass: encourage those who actually practice the faith. We contrast that fatherly posture with an impulse to homogenize—whether in worship or in how leaders talk about identity and assimilation. The throughline is consistent: distinct forms, memories, and practices keep people rooted. Erase them and you get a bland surface where convictions evaporate. We wrestle with obedience, courage, and prudence without pretending there's a single neat answer. Endure what purifies; resist where your duty to your family demands it. And stop popesplaining people's pain—compassion is not disloyalty.Along the way we share bright threads: a young seeker finding the Latin Mass, a Protestant pastor-turned-Catholic who brought seventeen souls with him, and a reminder that different voices in the Church play different roles. If worship shapes belief, then the task is simple and hard: guard the forms that train hearts to love God, name the costs honestly, and build communities that don't fold when the memo arrives. If this resonates, subscribe, share the episode with a friend who needs it, and leave a review so more displaced Catholics can find a lifeline.Support the showTake advantage of Recusant Cellar's "Christ the King" sale by heading over to https://recusantcellars.com/ and using code "REXCAELORUM" for 20% off at checkout!********************************************************Please subscribe! https://www.youtube.com/channel/UCKsxnv80ByFV4OGvt_kImjQ?sub_confirmation=1https://www.avoidingbabylon.comMerchandise: https://avoiding-babylon-shop.fourthwall.comLocals Community: https://avoidingbabylon.locals.comFull Premium/Locals Shows on Audio Podcast: https://www.buzzsprout.com/1987412/subscribeRSS Feed for Podcast Apps: https://feeds.buzzsprout.com/1987412.rssRumble: https://rumble.com/c/AvoidingBabylon

In this week's episode of The Energy Code, Dr. Mike Belkowski sits down with Victor Sagalovsky, co-founder of Litewater Scientific, to explore one of the most cutting-edge frontiers in mitochondrial optimization: deuterium depleted water (DDW). Victor, a longtime water researcher and pioneer in bringing ultra-low deuterium water to the world, shares how this overlooked isotope may hold the key to boosting energy production, extending healthspan, and even influencing genetic expression.   Expect a mix of quantum biology, practical lifestyle strategies, and a deep dive into the physics of water as Dr. Mike and Victor decode how lowering deuterium levels impacts mitochondrial health and human longevity. Key Topics Covered Victor's Origin Story – How a lifelong fascination with water led him to co-found Litewater Scientific and make deuterium depleted water accessible . What is Deuterium? – Breaking down the isotopes of hydrogen and why deuterium disrupts mitochondrial ATP synthase, causing “stutters” in energy production. The Mitochondrial Connection – How excess deuterium damages membranes, reduces proton motive force, and accelerates aging. Deuterium & Disease – The striking links between high deuterium levels, cancer risk, and neurodegeneration. Thresholds for Health – Why 120 ppm is considered the metabolic “line in the sand,” and how most modern water supplies far exceed this. How DDW is Made – The massive proprietary columns and energy-intensive process behind creating 10 ppm and 5 ppm light water. Psychological & Cognitive Benefits – Correlations between lower deuterium levels and improved mood, optimism, and confidence. Lifestyle Strategies – Beyond DDW: fasting, ketogenic diets, hydrogen inhalation, and limiting overconsumption of food and water. Practical Outcomes – How listeners can begin to measure, lower, and optimize their own deuterium levels for energy and longevity. Key Quotes   Victor Sagalovsky: “Every eight seconds, an ATP synthase stutters because of deuterium—it's the kiss and the elbow at the same time.” “Our physiology is designed for about 120 ppm of deuterium, but most people are sitting at 150 or higher—that's the metabolic danger zone.” “When you deplete deuterium, your body thanks you. You feel lighter, both metaphorically and literally.”   Dr. Mike Belkowski: “When I first tried Litewater, I felt an immediate pull—like my cells wanted more. It was magnetizing.” “The implications for cognition, mood, and even neurodegeneration are massive when you consider how mitochondrial dense the brain is.” Episode Timeline   00:00 – Introduction & the promise of radical life extension   01:30 – Dr. Mike introduces Victor and Litewater Scientific   04:00 – Victor's background as a water researcher and discovery of DDW   07:00 – Why deuterium is the hidden disruptor in energy production   12:00 – How ATP synthase “stutters” under deuterium load   18:00 – Membrane damage, proton leakage, and mitochondrial shutdown   24:00 – Cognitive, emotional, and energetic effects of lowering deuterium   32:00 – The massive engineering challenge of producing ultra-low deuterium water   39:00 – Deuterium and cancer risk: research, case studies, and suppression   46:00 – The “line in the sand” for ppm and metabolic safety   55:00 – Lifestyle strategies: fasting, keto, hydrogen inhalation, and exercise   01:00:00 – Testing, tracking, and maintaining optimal deuterium levels   01:03:00 – Closing thoughts on energy, freedom, and future of water Resources & References Litewater Scientific Book: Deuterium Depletion: A New Strategy in Cancer Therapy - Dr. Gabor Somlyai Dr. Zoltán Nagy – Research on ATP synthase stutter and deuterium's role Deuterium Depletion Resource Hub

Could the water you drink impact your gut health? In this episode, Dr. Greg Nigh discusses deuterium-depleted water, sulfur metabolism and hydrogen sulfide SIBO and their relationship with digestion, energy and overall health. You'll also hear practical insights on ketogenic and carnivore diets, plus emerging therapies like peptides and infrared light. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, X, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up your free 30-minute Gut Healing Breakthrough Session. Show Notes