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This week, we travel back to the Iberian Peninsula in the 11th Century CE and begin our discussion about one of the most formative events in the Western European historical tradition: The Reconquista. Traditionally, at least to Western historians, this has been a tale of the centuries long triumph of Christianity, Civilization, and Enlightened European Values over the despotic domination of the conquering Muslim hordes. This week we will introduce perhaps the most famous culture hero to emerge from this tumultuous era, El Cid, and explore the world into which he was born. Please consider checking out our Patreon: www.patreon.com/leftunread Follow us: @leftunreadpod @poorfidalgo @gluten_yung Email us: leftunreadpod@gmail.com Theme music courtesy of Interesting Times Gang, who have tons of cool tunes for sale here: www.itgang.bandcamp.com Happy Juneteenth :)
What is Polyvagal Theory and how does it explain the science of feelings? This week, Thomas sits down with Dr. Stephen Porges, a professor, author, and the originator of Polyvagal Theory. Dr. Porges' theory offers radical yet practical methods for calming our physical (or “biobehavioral”) states so that our mind can follow suit. Traditionally, the opposite approach has been the norm, but research increasingly indicates that the body should lead the charge. In this conversation, it's made clear that safety, connection, and co-regulation are essential for this type of nervous system regulation. Thomas and Dr. Porges explore what's needed to create an environment that supports healing, and how Polyvagal Theory enhances our ability to handle crises and heal trauma, anxiety, and physical ailments linked to nervous system dysregulation. Dr. Porges also shares a cutting-edge acoustic technique for trauma healing that could lead to a real paradigm shift in psychology and therapy. ✨ Click here to watch the video version of this episode on YouTube:
Going to the chapel! Or, in this case, a barn for a gleeful double wedding! Traditionally, you pop the champagne for a toast, but it was tequila behind the scenes! Jenna and Kevin have all the scoop on this star-studded episode, including Jenna’s tales from the bridal scene, getting tied up in knots watching Gloria Estefan in action, why Jennifer Coolidge told Kevin to sue FOX, and the scene where they were all losing it that took the cake! Plus, their thoughts on the double wedding storyline, why this episode was so groundbreaking, and cheers to the duo’s favorite Tina and Artie scene! It has a nice ring to it! For fun, exclusive content and behind-the-scenes clips, be sure to follow us on Instagram @andthatswhatyoureallymissedpod! See omnystudio.com/listener for privacy information.
In "Episode 6" of the series on "Present and future of diagnostics in prostate cancer", Assoc. Prof. Pawel Rajwa (PL) speaks with Prof. Peter Carroll (US) about the shifting landscape of active surveillance for intermediate-risk prostate cancer.Traditionally reserved for low-risk cases, active surveillance is now being considered for select patients with grade group 2 disease - especially when diagnosed through advanced techniques like MRI-targeted biopsy.Prof. Carroll explains how MRI has changed both the decision-making process and the biopsy approach, helping identify candidates with low risk of progression. The conversation addresses the potential to reduce overtreatment, minimise invasive follow-ups, and improve quality of life without compromising outcomes. Together, they examine how emerging data and imaging innovations are informing a more nuanced, patient-specific approach to prostate cancer care.For more EAU podcasts, please go to your favourite podcast app and subscribe to our podcast channel for regular updates: Apple Podcasts, Spotify, EAU YouTube channel.
An episode that busts the myth of 'perfect' creative processes!In Episode 140 of The Autistic Culture Podcast, Dr Angela Kingdon speaks with Sol Smith, author of The Autistic's Guide to Self-Discovery. If you've spent time on TikTok, YouTube, or inside the NeuroSpicy community, you've probably felt the impact of Sol's voice—direct, affirming, and deeply validating. He joins the show to help us rethink our relationship with writing routines, explore the realities of autistic creative rhythms, and bust the myth of 'perfect' creative processes.Plus, we announce our amazing winners from our fifth writing contest!Here are our top two entries.OUR WINNER
Witness to Yesterday (The Champlain Society Podcast on Canadian History)
Greg Marchildon speaks with Micah True about his book, The Jesuit Relations. The Jesuit Relations were annual reports written between 1632 and 1673 by Jesuit missionaries in what is now Eastern Canada. Traditionally viewed as firsthand missionary narratives, Micah True's work challenges this notion by revealing that the texts were shaped by many contributors—including Indigenous people, settlers, nuns, and editors in France. He explores the influence of historical context, such as Jesuit writing traditions and the Paris book trade, on their creation. True also examines how different editions since the 19th century have altered the interpretation of these texts. His analysis offers a more nuanced understanding of the Jesuit Relations and their role in shaping the history of New France and Indigenous-European encounters. Micah True is professor in the Department of Modern Languages and Cultural Studies at the University of Alberta. Image Credit: McGill-Queen's University Press If you like our work, please consider supporting it: bit.ly/support_WTY. Your support contributes to the Champlain Society's mission of opening new windows to directly explore and experience Canada's past.
Field support in franchising is often the make-or-break factor that determines whether a system thrives or stalls. While franchise development and operations get plenty of attention, the role of field coaching remains one of the most powerful, yet underutilized, levers for driving sustainable success across a franchise network. Angela Coté, Founder and CEO of Field Coach Experts, has made it her mission to transform how franchise brands think about field support. With over 25 years of hands-on experience growing M&M Food Markets to nearly 500 locations, Angela understands firsthand that franchisee success doesn't happen by chance—it happens through intentional, effective, and scalable support systems. Angela's work goes beyond traditional consulting. Through Field Coach Experts, she helps franchise systems build out the training, professional development, and best practices needed to maximize the impact of their field teams. Her approach is rooted in the belief that empowered, well-supported franchisees are the foundation for system-wide growth, brand consistency, and long-term profitability. At the core of field support in franchising is the relationship between the franchisor and the franchisee. Coté explains that strong field coaching is not about policing operations or enforcing compliance through fear. Instead, it's about developing trusted partnerships that empower franchise owners to reach their full potential. When franchisees feel supported—not scrutinized—they are far more likely to engage, perform, and remain committed to the brand's mission. Effective field support begins with redefining the role of the field coach. Traditionally seen as inspectors or operational enforcers, field coaches must now be positioned as business advisors, leadership mentors, and accountability partners. Coté emphasizes that today's franchisees expect more than just checklists—they want strategic conversations that help them overcome challenges, identify opportunities, and build better businesses. Angela also points out that field coaching isn't just about individual unit success. It plays a critical role in protecting brand integrity, ensuring consistency across locations, and creating a cohesive franchise community. When franchisees see the brand investing in their personal and professional growth, it creates a deeper connection to the system and fuels positive momentum across the network. Field support in franchising also needs to evolve to meet the demands of a changing business environment. Coté highlights how the rise of virtual communication, changing workforce expectations, and increasingly sophisticated franchisees require brands to rethink how support is delivered. Modern field coaching must be agile, proactive, and highly personalized to resonate with today's owners. Training field coaches is an essential piece of the puzzle. Coté advocates for a structured development path that equips field teams with the skills they need to succeed—not just operational knowledge, but also leadership coaching, relationship-building, and emotional intelligence. Franchise brands that invest in developing their field teams set themselves apart in a competitive market. Another critical aspect Angela stresses is the need for data-driven coaching. Successful field support programs leverage performance metrics, benchmarking, and goal setting to guide conversations and track progress. Without measurable results, coaching can easily become subjective or disconnected from the broader business objectives. Field support in franchising is ultimately about creating a win-win dynamic. When field teams are trained to coach rather than police, and franchisees are given the tools and encouragement they need to thrive, the entire system benefits. Unit-level profitability improves, brand loyalty deepens, and expansion opportunities grow stronger. Angela Coté's approach offers a fresh, forward-thinking blueprint for franchise systems ready to take their support programs to the next level. By investing in people, relationships, and strategic field coaching, franchisors can build healthier, more resilient brands that drive success for every stakeholder. Watch the full episode on YouTube. Don't miss future episodes featuring powerful conversations and actionable insights from today's top business minds. Join Fordify LIVE! Every Wednesday at 11AM Central on your favorite social platforms and catch The Business Growth Show Podcast every Thursday for a weekly dose of business growth wisdom. About Angela Coté Angela Coté is the Founder and CEO of Field Coach Experts, a leading advisory firm helping franchise brands maximize the impact of their field support teams. With over 25 years of experience in franchising—including helping grow the iconic M&M Food Markets brand to nearly 500 locations—Angela has become a champion for improving franchisee engagement, profitability, and brand success through strategic coaching and development. Her real-world insights and passion for transforming the franchise industry have made her a trusted advisor for franchisors ready to level up their systems and drive sustainable growth. To explore more about Angela Coté and Field Coach Experts, visit FieldCoachExperts.com. About Ford Saeks Ford Saeks is a Business Growth Accelerator who has helped generate over a billion dollars in sales for organizations ranging from startups to Fortune 500s. With more than 20 years of experience, he's redefined what it means to drive success—combining strategic marketing, innovation, and real-world business acumen. As the President and CEO of Prime Concepts Group, Inc., Ford helps businesses attract loyal customers, expand brand visibility, and improve performance at every level. He's founded over ten companies, authored five books, earned three U.S. patents, and received numerous industry accolades for his work in marketing, leadership, and entrepreneurship. A trailblazer in digital innovation, Ford is also an expert in AI prompt engineering, training businesses to use tools like ChatGPT to create high-impact content and elevate customer engagement. He recently shared his expertise at the “Unleash AI for Business Summit,” where he spoke on the role of AI in transforming operations, marketing, and the customer experience. To learn more, visit ProfitRichResults.com and watch his business TV show at Fordify.tv.
In this episode of Quality Matters, Julie Seibert, Assistant Vice President of Behavioral Health at NCQA, joins host Andy Reynolds to explore the rise of—and the relationship between—two trends in behavioral health: measurement-informed care and peer support. Julie breaks down how these strategies improve outcomes, engage patients and close gaps in access and accountability.Listen to this episode to discover: How Measurement-Informed Care Engages Patients: Learn how measurement-informed care supports patient engagement and treatment adjustments in behavioral health. We explore the importance of ongoing assessment, tracking symptoms and outcomes and empowering patients to understand their journey. Friction and Fuel for New Approaches: We unpack historical challenges to measurement-informed care. These include the omission of behavioral health from key legislation and the costs of EHR integration. We also discuss how NCQA depression measures and person-centered outcome measures relate to measurement-informed care.Benefitting From Peers' Lived Experience: We discuss how people who have been through mental health or substance use treatment can provide non-clinical support to help others navigate the system, subvert stigma and fill care gaps.This discussion is a valuable resource for providers, policy leaders and others who care about improving access, engagement and outcomes in behavioral health.Key Quote:"Measurement-based care has been around for a long time and only 20% of behavioral health providers adopted it.Traditionally, these are trained clinicians. And in the course of a session with a patient, probably in the back of their mind, they're evaluating whether an individual is improving or has worsening function.Payers would like some numerical or standardized way of seeing the clinician's clinical judgment. Measurement-informed care offers that."Julie SeibertTime Stamps:(03:04) Who's Behind Measurement-Informed Care(05:08) HEDIS and Measurement-Informed Care(08:13) Person-Centered Outcome Measures in Behavioral Health(09:58) The Power of Peer Support Specialists(11:57) Addressing Workforce Shortages(15:37) Why States Support Peer Support(16:32) Peer Support's Connection to Measurement-Informed CareDive Deeper:Blog: How Peer Support Can Help Close the Gaps in Behavioral HealthcareBlog: Measurement-Based Care in Behavioral HealthQuality Matters Episode 13: Getting Clear About Behavioral HealthConnect with Julie Seibert
On this episode of Destination on the Left, I talk with Patrick Keyes, Sales and Marketing Manager at Rainbow Air Helicopter Tours in Niagara Falls, about why he believes in coopetition and how collaborations with his competitors have helped him be successful. Patrick explains why being a first call partner to your local and regional DMO is so important, and how you can position yourself to be that partner. He also offers valuable advice on how to work collaboratively at trade shows to build success. What You Will Learn in This Episode: How Patrick developed a regional, visitor-centric mindset by looking beyond traditional industry boundaries Why Patrick firmly believes that coopetition drives success for individual businesses and the broader destination What innovative steps Rainbow Air Helicopter Tours is taking to transform into a year-round, multifunctional attraction, including their new facility and virtual reality experiences Why partnering with local and regional DMOs (Destination Marketing Organizations) allows you to maximize marketing opportunities and industry influence Strategies Patrick uses when attending industry trade shows to represent both his own company and the wider Niagara region, and how this approach builds stronger relationships How Patrick seeks out unconventional partnerships, like collaborations with wineries and golf courses, to create memorable experiences and extend visitor stays in the region Leveraging Collaboration for Year-Round Tourism One of Rainbow Air's boldest moves has been the development of a new 30,000-square-foot tourism center. This ambitious facility isn't just a ticket counter; it's set to become a hub of activity through every season. Traditionally, tourism in Western New York peaks from Memorial Day to Labor Day, but Patrick and his team saw the need for more. The new tourism center, set to open over Memorial Day weekend, will feature a range of amenities, including gift shops, restrooms, and innovative virtual reality attractions, such as parasailing over Niagara Falls. By offering a range of experiences and amenities, Rainbow Air aims to both attract off-peak visitors and encourage them to extend their stays, laying the groundwork for sustainable year-round tourism. The Power of Partnerships A recurring theme throughout Patrick's career is the essential role of strong relationships with Destination Marketing Organizations (DMOs), regional partners, and fellow attractions. As part of Rainbow Air, he is able to attend trade shows globally, but Patrick insists on representing the region, not just his company. “Know your audience, do your research, and come prepared to advocate for not only your attraction, but complementary experiences that round out the destination,” he advises. Forming partnerships with other attractions enables a rising tide that lifts all ships. Being proactive, communicating openly, and showing a genuine commitment to representing the community as a whole are so important. When DMOs trust that you'll be a reliable, high-quality option, you're top of mind for press trips, FAM tours, and state-led opportunities. Creative Collaborations Rainbow Air's vision for cross-industry cooperation doesn't stop at helicopter tours. Patrick is exploring partnerships with local wineries, golf courses, and historical sites. Imagine custom packages where visitors enjoy an aerial tour before being whisked away to a vineyard for a picnic. Or collaborating with the local wine trail for multi-stop experiences. By thinking creatively about what both locals and travelers want, Rainbow Air extends an invitation for everyone to participate in the region's success. What excites Patrick most is not just Rainbow Air's growth, but the chance to be “a beacon” for others in Niagara Falls. By investing in innovation and actively inviting everyone to the table, he hopes to create a mutually beneficial model, one where attractions, large and small, lean on each other to make the region irresistible and vibrant, every season of the year. Resources: Website: https://www.rainbowairinc.com/ LinkedIn: https://www.linkedin.com/in/patrick-keyes-1001186/ We value your thoughts and feedback and would love to hear from you. Leave us a review on your favorite streaming platform to let us know what you want to hear more of. Here is a quick tutorial on how to leave us a rating and review on iTunes!
News; birthdays/events; there are many topics we don't discuss at the holiday table...but 40% of us don't allow those same topics to be discussed at the table any time...agree?; word of the day. News; game: backwards song game; it used to just be sci-fi..but our faces can unlock so many things...now maybe even the doors to our homes!; people and their strange hobbies. News; have you ever had to cancel plans/call out of work because of something on your face (giant zit etc)?; 17% of us haven't done much physical activity since high school...what haven't you done since H.S.? things you shouldn't feel guilty about splurging on. News; game: battle of the sexes part 1; game: battle of the sexes part 2; goodbye/fun facts....Chocolate Macaroon Day...the macaroon originates from Italy and means paste. It is believed that macaroons originated some time in the 8th or 9th century in an Italian monastery. The desserts were introduced in France in 1533 when monks from the monastery joined King Henry II's pastry chef. Traditionally made with shredded coconut, almond flour, sugar or sweetened condensed milk and egg whites. Eventually, shredded coconut replaced the almond flour. Because they did not contain any flour, Jews in Italy ate them as treats during Passover. In 1903, macaroons appeared in a cookbook under a recipe for “coconut kisses.” Macaroons recently made one popular website's top 16 list of “All-time Favorite Cookies".
Buy Now Pay Later is a short-term loan that allows consumers to pay for their items in small installments over time. However, due to the popularity of Buy Now Pay Later, there has been an increase in what many have started to label “phantom debt”. Links: Learn more about this Money Tip's sponsor: New England Royal Service Explore debt consolidation loan options from Triangle Credit Union Watch our Financial Freedom webinar for tips on how to manage and get out of debt Check out TCU University for financial education tips and resources! Follow us on Facebook, Instagram and Twitter! Learn more about Triangle Credit Union Welcome to Money Tip Tuesday from the Making Money Personal podcast. Today's Money Tip is proudly sponsored by New England Royal Service. A local NH business offering commercial cleaning and property maintenance trusted for its exceptional service. Visit neroyal.com to learn more and show us a little love by mentioning this podcast when you reach out! Now back to today's tip. The term phantom debt can mean multiple things. Traditionally, phantom debt is a debt that is too old to collect legally, so it's either written off or sold to a collection agency. Phantom debt may also refer to when scammers try to collect money that is not owed to them by threatening legal action. However more recently, phantom debt has come to mean a debt that can't be measured since it's not reported. According to many reports, Buy Now Pay Later is a large producer of these unmeasured phantom debts. Because of its convenience, consumers are finding it easier to use Buy Now Pay Later services to pay for larger items in smaller installments than paying for it all upfront. However, that means people are using Buy Now Pay Later to buy more big-ticket items than they can actually afford. This results in loan stacking, which is borrowing multiple loans at the same time. With more and more of these Buy Now Pay Later loans, it can be difficult for consumers to keep track of them. If you don't pay these loans on time, you will get hit with late fees and your credit score will lower. If you're struggling with Buy Now Pay Later debt, aka “Phantom Debt”, there are a couple things that you can do. The first thing you can do is request a payment extension. Some Buy Now Pay Later lenders will let you either change or extend the payment due date which can provide some much-needed extra time pay off the debt. You could also apply for a debt consolidation personal loan, which would combine some or all of your debts into one single loan. This not only makes it easier to keep track of existing debt but it can even help improve your credit score as you make those regular, consistent payments to pay it all off on time. If there are any other tips or topics you'd like us to cover, let us know at tcupodcast@trianglecu.org. Also, remember to like and follow our Making Money Personal Facebook and Instagram to share your thoughts. Finally, remember to look for Triangle Credit Union, on Facebook and LinkedIn.
This week, Sahra Halpern, who is CEO of the Business Consortium Fund, talks about a type of lender that is not particularly well known or well understood even among business owners. The Business Consortium Fund is a CDFI, or community development financial institution. Traditionally, many CDFIs, including Halpern's, have sought to serve underrepresented business owners who have struggled to get a traditional bank loan. In the current political climate, however, CDFIs are looking to reach a broader audience. In our conversation, Halpern talks about how CDFI lending differs from bank lending and what types of business should consider approaching a CDFI.
Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains, "We're coming into play here in supporting healthcare brands and better understanding the providers as people. As I mentioned, we're a people-based data company. I'd say that in an era where data is abundant and there is no shortage of health data being gathered and analyzed. So, you've got a lot of data assets out there that are coming from clinical trials, your real-world evidence, claims data, your electronic health records, all of which give insight into the aspects of a provider from a clinical setting. Traditionally, healthcare providers have been viewed primarily through the lens of their professional lives, their specialties, their role in patient care, prescription-writing behaviors, and even their affiliations. And these are super important factors. We do see those truly as table stakes, but they paint an incomplete picture." "Providers, like patients, have unique lives, needs, and preferences, which really shape how they interact with the work they do and the brands they seek to engage with. The industry is really recognizing these nuances, which presents a unique opportunity for healthcare brands to acknowledge the complexity of the providers' lives beyond what you could say are their white coat moments, and differentiate their message. And so this can dig into driving more meaningful engagement. And for us here at AnalyticsIQ, we're focused on helping to understand healthcare providers, or HCPs, more broadly, and understanding some of their personal characteristics. So, the data we're bringing to the table to complement all the other data in the ecosystem will be things like considering their work-life balance." #AnalyticsIQ #HealthcareData #HealthcareAnalytics #HealthTech #HCPengagement #PatientExperience #ValueBasedCare #PersonalizedCare #HealthEquity #SDOH #HealthcarePrivacy #PatientData analytics-iq.com Download the transcript here
Christine Lee, Head of Health Strategy and Partnerships at AnalyticsIQ, focuses on helping healthcare brands and pharmaceutical companies better understand and engage with healthcare providers by taking into account data beyond their professional lives. This data-driven Provider as a Person approach analyzes the healthcare professional's personal characteristics, outside interests, decision-making style, and preferred method of communication. The goal is to foster more meaningful relationships with providers, address provider burnout, and improve patient outcomes. Christine explains, "We're coming into play here in supporting healthcare brands and better understanding the providers as people. As I mentioned, we're a people-based data company. I'd say that in an era where data is abundant and there is no shortage of health data being gathered and analyzed. So, you've got a lot of data assets out there that are coming from clinical trials, your real-world evidence, claims data, your electronic health records, all of which give insight into the aspects of a provider from a clinical setting. Traditionally, healthcare providers have been viewed primarily through the lens of their professional lives, their specialties, their role in patient care, prescription-writing behaviors, and even their affiliations. And these are super important factors. We do see those truly as table stakes, but they paint an incomplete picture." "Providers, like patients, have unique lives, needs, and preferences, which really shape how they interact with the work they do and the brands they seek to engage with. The industry is really recognizing these nuances, which presents a unique opportunity for healthcare brands to acknowledge the complexity of the providers' lives beyond what you could say are their white coat moments, and differentiate their message. And so this can dig into driving more meaningful engagement. And for us here at AnalyticsIQ, we're focused on helping to understand healthcare providers, or HCPs, more broadly, and understanding some of their personal characteristics. So, the data we're bringing to the table to complement all the other data in the ecosystem will be things like considering their work-life balance." #AnalyticsIQ #HealthcareData #HealthcareAnalytics #HealthTech #HCPengagement #PatientExperience #ValueBasedCare #PersonalizedCare #HealthEquity #SDOH #HealthcarePrivacy #PatientData analytics-iq.com Listen to the podcast here
Lene Hellstern, Director of Engineering at PEAK Wind, discusses the complexities of onshore wind siting, the advantages of using LIDAR technology, and strategic considerations for turbine selection. Sign up now for Uptime Tech News, our weekly email update on all things wind technology. This episode is sponsored by Weather Guard Lightning Tech. Learn more about Weather Guard's StrikeTape Wind Turbine LPS retrofit. Follow the show on Facebook, YouTube, Twitter, Linkedin and visit Weather Guard on the web. And subscribe to Rosemary Barnes' YouTube channel here. Have a question we can answer on the show? Email us! Allen Hall: We're back with Lene Hellstern, the Director of Engineering at PEAK Wind, and we're talking about onshore wind siting, which is a really critical issue that a lot of operators have difficulties with. And I've seen it in the United States and it's not good. And I'm wondering from your perspective, what are some of the problems, Lene? Well first, welcome back to the podcast. Lene Hellstern: Thank you. And thanks for having me repeat experience last time, so I hope so. I thought I'll pop in again. Allen Hall: Well, it's good to have you back and thanks Lene Hellstern: for coming to Copenhagen. Allen Hall: Yeah, well we love Copenhagen. It's great. Uh, I just wish it was a little bit warmer. Yeah, the sun is terrific. Yeah. When you're in it, well, at Lene Hellstern: least I fixed that. Right. Yes. It's not raining. It's not raining. Yes. Allen Hall: We, we quite enjoyed it. Uh, but I'm trying to get an understanding of what the underlying issues are with onshore wind siding and why some of the operators have difficulty later on. Let's just start with the sighting [00:01:00] itself. Yeah. Is usually, we'll see a wind mast out on site for several months, maybe a year, maybe two years. To try to get some wind data. We would Lene Hellstern: really like that. Yeah. Okay. But, uh, the preferable measurements are lidars. Allen Hall: Oh, lidars. Yeah. I have not seen a lot of lidars in use. Lene Hellstern: No. You, you need to get some more. Allen Hall: Why? Lene Hellstern: Um, because they reach higher. Allen Hall: Okay. Lene Hellstern: Um, and you can, uh, you can, you can move them around. Right. And the hassle of installing a Met Mass that's a hundred meters tall, is, uh, is it a problem? Quite, uh. Quite it, it cost a lot more. Yes. Um, and, and the lidars, they, they just, they're better and they measure higher. And you can, you can have one sort of mother lidar and then you can move the other around and you can cover your wind resources and site suitability much better on the site. So I would definitely recommend Allen Hall: lidars. Okay. How the lidars use a [00:02:00] good bit of power to make them run, correct? Yes. So you need a decent power source? Yes. Lene Hellstern: You do? Yes. Allen Hall: Okay. Yeah. I, is that one of the difficulties why they don't use a lidar? Is it just in a lot of remote areas, they don't have the power source to run it? Lene Hellstern: It could be, or it could be the, the lack of knowledge. Right. Traditionally we have used med masks, yes. Allen Hall: Forever. Lene Hellstern: Uh, so, so it could be, and then there are also some, um, uh, some issues with uncertainties because the lidar is the, the standards are not up to date. I would say that's the political way correct way of saying it. So. Eh, the standard actually introduces more uncertainty on the lidar that's really not necessary to, due to a calibration with a me mast. Um, so that there's some, there's some things that needs to improve in that area Allen Hall: because a lidar should be a lot more accurate than a met mast. Lene Hellstern: Yes. Yeah. Yeah. But, but the, the downside of the lidar, so that, that is not often we see that, is if you don't have enough particles in the air,
Send us a textIn this Writers' Room conversation with author Susan Tate Ankeny, author of two historical works, we talk about her journey to publish her first book, The Girl and the Bombardier: A True Story of Resistance and Rescue in Nazi Occupied-France about her father's experience in WWII, and how that led to her agent offering her the opportunity to write and publish, American Flygirl, about WWII WASP Hazel Ying Lee. Did you know you can support your local independent bookshop and me by shopping through my Bookshop.org affiliate links on my website? If a book is available on Bookshop.org, you'll find a link to it on the book page. By shopping through the Literary Aviatrix website a small portion of the sale goes to support the content you love, at no additional cost to you. https://literaryaviatrix.com/shop-all-books/Thanks so much for listening! Stay up to date on book releases, author events, and Aviatrix Book Club discussion dates with the Literary Aviatrix Newsletter. Visit the Literary Aviatrix website to find over 600 books featuring women in aviation in all genres for all ages. Become a Literary Aviatrix Patron and help amplify the voices of women in aviation. Follow me on social media, join the book club, and find all of the things on the Literary Aviatrix linkt.ree. Blue skies, happy reading, and happy listening!-Liz Booker
This discussion provides an overview of fundamental concepts in real property law. They explain different types of ownership interests, including fee simple estates, outlining the rights associated with owning land and attached structures. The texts also discuss how property interests are transferred, covering topics like deeds, mortgages as security interests, and recording statutes. Furthermore, they explore nonpossessory interests in property, such as easements, covenants, and servitudes, which affect how land can be used, alongside the government's power of eminent domain and the restrictions imposed by zoning laws. The sources highlight the legal doctrines and procedures surrounding these concepts.TakeawaysNon-possessory rights include easements, profits, and covenants.Easements allow use of another's land; profits allow resource extraction.Covenants can be real or equitable, affecting enforcement options.The Restatement Third of Property aims to unify property interests under servitudes.Moral obligation to keep promises is a key reason for enforcing covenants.Dead hand control concerns arise with perpetual restrictions.Traditionally, courts favored enforcing easements over real covenants and equitable servitudes. The American Law Institute's Restatement (Third) of the Law of Property unified these concepts under the term "servitudes" to simplify and rationalize the law.A prospective owner could purchase the property at its lower, encumbered market price and simultaneously negotiate and pay the holder of the servitude an amount to release it. This allows the purchaser to acquire the property free of the restriction.The two essential conditions are that the property must be used for a "public purpose only," and the property owner must be "compensated at fair market value."Inverse condemnation is an action initiated by a property owner when government regulation is so substantial that it effectively amounts to a taking, even without formal condemnation proceedings. Direct eminent domain is the government explicitly using its power to take private property.The "bundle of rights" concept views property ownership not as a single right, but as multiple distinct rights that can be held separately. Key rights include the right to possess, use, exclude others, enjoy benefits, and transfer interests. (Any two of these are acceptable).Fee simple is an estate of indefinite duration in real property that can be freely transferred. It is considered the most common and absolute type of estate, granting the owner the greatest discretion over the property's disposal.An estate for years is a leasehold that endures for a fixed, predetermined period and ends automatically without notice. A periodic tenancy endures for successive intervals (e.g., month to month) until properly terminated by notice equal to the length of the period (or as prescribed by statute).In most jurisdictions, a landlord has a duty to make reasonable efforts to re-let vacated premises if a tenant wrongfully abandons the lease. This duty is to reduce the landlord's losses and prevent them from allowing the property to remain empty while still suing for the full rent owed.Adverse possession is a legal doctrine allowing a trespasser to acquire valid title to land by occupying it in a continuous, exclusive, open, notorious, and hostile manner for a statutory period. The public policy motivation is to reward productive land use, quiet title disputes, and resolve boundary issues, discouraging neglected property.A grant deed is written proof that the property title is owned free and clear of claims or liens and promises that the property hasn't been sold to anyone else. A quitclaim deed transfers whatever interest the grantor has in the property, without making any warranties or guarantees about the title.property law, non-possessory interests, easements, covenants, eminent domain, legal concepts, law students, property rights, zoning, land use
Traditionally, litigators seeking to understand an individual's or organization's devices - specifically, how they store, access, manage, and delete information - have either asked a deponent to testify from memory or arranged for a costly forensic inspection instead. In this episode, Jim spotlights a fantastic middle ground: requiring a deponent (individual or 30(b)(6) rep) to bring their devices to the deposition and demonstrate their functions and programs or apps during a videotaped examination. This technique was just approved by a federal judge in a pending class action against the ride-sharing company Uber. It's one all litigators should be using. As Jim says in the episode, devices are where information now lives. Lawyers should be more aggressive in their pursuit of discovery related to devices an individual or entity owns and how they access, store, manage, and delete data.SHOW NOTESIN RE: UBER TECHNOLOGIES, INC., PASSENGER SEXUAL ASSAULT LITIGATION, No. 23-MD-03084-CRB (LJC), 2025 WL 1393216 (N.D. Cal. May 14, 2025); See Joint Discovery Letter Brief on Plaintiff's 30(b)(6) deposition notice seeking device demonstration is Document 2957; Order Resolving Discovery Letter Regarding Rule 30(b)(6) Depositions is Document 2995.Section 9.43, Physical Demonstrations By Deponents, p. 357-359, in the book 10,000 Depositions Later - The Premier Litigation Guide For Superior Deposition Practice: A User's Guide and Handbook on Deposition Tips, Tactics and Strategies for Civil, Administrative and Arbitrative Litigation, 4th Edition, 615 pp., by Jim Garrity, Esq., available on Amazon and just about everywhere else books are sold.
Traditionally liver has a bad rep in this country. However, this dish has its origins in Italy, where spring lamb is highly anticipated and well worth the wait. Try it – you may be surprised.
What is the state of syndications today? How to structure a syndication for protection purposes? Major differences between funds vs syndications and why are funds popular today? Jonathan Tavares, Managing Partner at Premier Law Group, shares his insights. Read the entire interview here: https://tinyurl.com/25hhhjsfWhat is the state of the market today? What are the IRRs looking like? Are you seeing more or fewer deals come across your desk?There has been a shift to funds in the last 6-8 mos. Traditionally, especially during COVID, a lot of clients were doing a lot of multifamily syndication. Now, granted, that's been a piece that we focused on for a long time. A lot of our clients are heavily involved in the multifamily space, but with increasing interest rates over 22 and various other factors, property taxes throughout many counties and throughout the country, going up very quickly, as well as insurance and specific markets. We have a lot of clients in various markets in Texas that have just gone crazy, places like Houston or Florida, where insurance rates have skyrocketed. It's presented some challenges for some of our clients. Instead of seeing just a straight deal with a certain percentage of debt somewhere around 70- 80%, a lot of times, there's a lot of creative financing going on to make up for that debt piece that may not be there or where those percentages of debt to purchase price may be a little bit lower than what a lot of clients were used to before.You see a lot of preferred equity. We've seen clients building out structures where, in essence, they're providing almost a debt structure to their investors too, to create a sort of debt piece as well as an equity piece in their raises. We've seen a lot of clients create funds and use their funds to come in for part of the debt piece for specific projects as well.Depending on the asset type, and I'll specifically exclude development projects, we're seeing a lot of target IRRs between 15 and 20% generally.Where do all the LLCs go for a syndication so that everyone is protected as much as they can possibly be?There's all sorts of different structures that you might use to set up a syndication or a fund and for different reasons, for tax reasons, for asset protection reasons, etc. A typical syndication structure is going to include a syndication entity, and that's typically known as the issuer entity, that's the entity that's selling securities.Why does the SEC care about what I'm doing if I'm raising capital to go buy real estate? The Supreme Court came up with a test that's called the Howie test. The SEC does an analysis to determine if you were selling securities or not, and essentially boils down to the four main tenets of the Howie test:1) Is an investor investing money? Typically, the answer is yes.2) Are they expecting some sort of return on profits? And usually the answer is yes.3) Whether the efforts are generated by someone other than the person who's investing, like some sort of promoter, or in the space we call a sponsor. In these deals, a sponsor where a GP that is raising the capital from investors. The investors are passive in the deal. 4) A common enterprise is if the investors are pooling together capital through the efforts of the GP to buy some sort of underlying investments. That's typically going to be real estate.Jonathan Tavares(508) 212-1193jonathan@plglp.comwww.premierlawgroup.netJoin our investor list at https://montecarlorei.com/investors/
Send us a textI think it was the James Bond Roleplaying game, or maybe it was Twilight 2000. My memory is a little fuzzy on this one, but there was a point in my roleplaying past where I started running adventures set in the modern era,And I loved it.Traditionally table top roleplaying games have focused on the Fantasy. Tolkien's world or some variation of it has the been the centerpiece for TTRPGs from the beginning and many of you have never ventured outside of that setting. Other games over time have added settings some historical like Call of Cthulhu, some futuristic like Traveller, but many have just avoided the modern era.While there are a lot of games out there that do have a modern setting most of you don't play them. Games like Delta Green, Twilight 2000, Feng Shei, World of Darkness, Everyday Heroes, GURPS, Kids on Bikes, Double Zero, Masks and Kult are all built on modern settings and I would argue that instead of being afraid of running games in a modern setting you should embrace it. I find it much easier to run games in modern settings and with just a few tweaks here and there you can have some amazing adventures.On this episode Christina and I are going to talk about running games in Modern settings and give you some tips and tricks that can help you keep your games running smoothly.Christina was Masks the first game you ever ran in a modern setting?
3 Key Ways Estate Agents Can Speed Up Property Exchanges. Are you an estate agent looking to speed up property exchanges and close deals faster? In this episode, we're joined by Sally Holdway, LawTech strategist and co founder of the Home Owner's Passport, who shares three essential strategies to help you streamline the process. First up, Sally discusses preemptive sales progression, which involves getting key documents like title deeds and property forms ready early. By tackling material information up front, you can prevent delays and avoid unnecessary back and forth later on. Sally explains how taking a proactive approach can put you in the driving seat, helping you stay ahead of potential issues. Next, we dive into the question of whether to go for fixed fee conveyancing or chase higher referral fees. Sally walks through the trade offs between the two options, helping you decide what's best for you in terms of speed, cost, and service. Finally, Sally highlights the importance of building strong relationships with conveyancers. Traditionally, estate agents and solicitors have had a bit of a strained relationship, but with the right approach, you can work together from the outset to ensure smoother, faster transactions. Don't miss out on these practical tips to boost your efficiency and win more business. Listen to the full episode now, share your thoughts in the comments, and let's get those exchanges moving!
The podcast features Elizabeth Chamberlain, Director of Sustainability at iFixit, discussing the Right to Repair movement and its impact on the lighting industry. Traditionally, lighting was designed with standardized, replaceable components, ensuring easy repairs. However, modern LED fixtures often have non-repairable parts, leading to more electronic waste. Liz explains iFixit's mission to provide free repair guides and advocate for laws requiring manufacturers to support independent repairs. Michael and Greg argue that lighting should return to its repairable roots, emphasizing sustainability and waste reduction. Liz Chamberlain is Director of Sustainability at iFixit, where you can find everything you need to fix consumer gadgets (and more). She heads the company's fight for the Right to Repair, which is the idea that you should be able to fix everything you own and manufacturers shouldn't be able to stop you. Her writing about repair and e-waste has been published in The Wall Street Journal and Wired, and she's been interviewed for NPR and Vox. Connect with Liz: www.ifixit.com www.linkedin.com/in/elizabeth-chamberlain-4a96264a/ X: liz_ifixit facebook.com/iFixit instagram.com/ifixit Sponsor: Griplock Systems griplocksystems.com
A gray overcast day makes sense while we in Canada celebrate our ever increasingly anarchonistic holiday "Victoria Day". Traditionally this is known as the May two four weekend. Two four being common slang for a case of beer. While I don't really drink anymore, I'll be going out to resupply my stock of Root Beer, as I seem to have slightly regressed a bit back into childhood. Sex Code - Your Silent Face Studio-X - Clouds & Trees (Elektrostaub) Retrojunkies - Unterwelt (Massiv In Mensch) Exsequor - The Fallen Digital Energy - Addicted To You MONO_XYD - Lessons II (Monya) Core In Motion - Fire In My Eyes (Sonic Sound Factory) VNV Nation - Station 21 http://synthetic.org/ https://www.youtube.com/@RealSyntheticAudio
Taking refuge and making vows are not subjects we speak about in casual conversation, even with ourselves! Traditionally, we think of a formal ceremony where a teacher is initiating a group of students into the commitment of embracing Buddhism as their path.Read the Journal while listening
John Quinn is joined by Michael Barlow, Managing Partner and Founding Member of Quinn Emanuel's Wilmington, Delaware office. They discuss the evolving state of Delaware corporate law and the legislative response to growing dissatisfaction among corporations over the recent legal treatment of conflicted transactions. Traditionally, Delaware law has deferred in general to corporate decision-making under the business judgment rule, but rigorously reviewed transactions involving conflicts of interest—particularly those involving controlling shareholders—under an “entire fairness review.” Entire fairness reviews are fact-intensive and include scrutinizing both the process and terms of the transaction, making early dismissal of claims rare. In response, Delaware courts developed a safe harbor called the “MFW” framework. The “MFW” framework involved approval by a special committee of disinterested directors and the minority shareholders. Still, even under the MFW framework, motions to dismiss were granted in fewer than 40% of cases, leading to frustration among deal planners.Despite these odds, a Quinn Emanuel team led by Michael recently won a rare complete dismissal of an entire fairness case on behalf of Fidelity National Financial, Inc. In that case, the court ruled that there were no alleged facts that could support the conclusion that the preferred stock transaction at issue was unfair. Frustration among corporate deal planners with what was perceived as activist judicial decisions creating uncertainty (e.g., as to what was a “controlling stockholder,” among other things) has recently led to Tesla, Dropbox and other corporations to express their intent to leave Delaware as their state of incorporation. “DExit,” is the term coined to describe this trend. To address these concerns, Delaware enacted Senate Bill 21, a bipartisan effort to clarify and narrow the standards for conflicted transactions. The legislation provides clearer definitions of controlling stockholders and establishes safe harbors for dismissing cases early if certain procedural protections are followed. It also reforms the state's books-and-records statute (Section 220) by limiting the scope of pre-suit corporate document demands. The next few years will test how effectively the new legislation meets the corporate world's demand for greater legal certainty. Finally, Michael believes that Delaware will continue to lead the nation in corporate law due to its unparalleled legal infrastructure and judicial expertise. Podcast Link: Law-disrupted.fmHost: John B. Quinn Producer: Alexis HydeMusic and Editing by: Alexander Rossi
In the first episode of the podcast, hosted by Steve Bell and Nerida Jessup, we focus on a contemporary issue for Australian workplaces - psychosocial health and safety. Traditionally centred on physical risks, there has been a significant shift over the past five years towards managing non-physical risks such as bullying and sexual harassment. This now includes considerations on how work is performed, allocated, and designed to help employees thrive. This episode highlights the increased regulation and enforcement in this area more recently, emphasising the need for developing risk registers to identify psychosocial risks and implementing consistent controls. It also notes the growing expectation for HR and people and culture teams to adopt the language of work health and safety and risk management, offering practical tips on how to effectively manage these changes.
Camogie players have criticised the sport's association for kit rules deemed as ‘archaic'. Traditionally, camogie players have worn skorts in their kit, but players are now asking for the choice to wear shorts. Following widespread disruption over the issue, a vote is due to take place next week. Are camogie skorts sexist, or just a harmless tradition? Olivia Peden is joined by the Belfast Telegraph reporters Niamh Campbell and Jessica Rice. Hosted on Acast. See acast.com/privacy for more information.
The agricultural industry has long been at the forefront of technological innovation, continuously seeking ways to enhance productivity, efficiency, and sustainability. A significant development in this realm is the emergence of autonomous robots specifically designed for pesticide application in orchards. Jongwoo Ha from Hada explores the design, functionality, and potential impact of these robots across the world.The Need for Automation in AgricultureAgriculture remains one of the most labor-intensive sectors, often requiring repetitive tasks that can be physically demanding and time-consuming. Pesticide application is a prime example of such a task. Traditionally, farmers have relied on manual labor or machinery that requires human operation, exposing workers to health risks associated with chemical exposure. The need for a safer, more efficient solution is evident, and this is where autonomous robots come into play.Design and Functionality of the Autonomous Pesticide Spraying RobotThe autonomous pesticide spraying robot developed by Hada is designed specifically for use in orchards, targeting crops such as apples and oranges. Its design is both practical and innovative, resembling a small car in size, which allows it to navigate orchard rows effectively. The robot features a trunk-like structure equipped with spring nozzles that extend outward, mimicking the branches of a tree. This design enables the robot to spray pesticides at various heights, accommodating trees that can grow up to three meters tall, with the capability to reach up to five meters to account for wind dispersion.One of the standout features of Hada's robot is its ability to pivot the nozzles, allowing for precise application depending on the height of the trees. This adaptability not only enhances the effectiveness of pesticide delivery but also minimizes waste and environmental impact. The robot operates autonomously, utilizing advanced sensors and navigation systems to traverse the orchard without human intervention, thus reducing labor costs and mitigating health risks for workers.Production and Market PotentialAfter three years of development, Hada plans to launch the autonomous pesticide spraying robot by mid-2025. While the initial focus is on the Asian market, the company has expressed a willingness to explore opportunities globally. During the CES event, the team recognized the potential for their technology in regions like Africa, where the demand for autonomous agricultural solutions is growing. The signing of a memorandum of understanding (MOU) with a partner from Togo highlights the company's commitment to expanding its reach and impact.The Broader Implications of Autonomous Agricultural RobotsHada's introduction of autonomous robots for pesticide application represents a significant shift in agricultural practices. By automating the spraying process, these robots not only improve efficiency but also address critical issues such as worker safety and environmental sustainability. The ability to apply pesticides precisely reduces chemical runoff and minimizes the ecological footprint of farming practices.Moreover, the potential for global distribution of these robots opens up new avenues for agricultural innovation in developing regions. As the company noted, autonomous agricultural robots do not recognize geographical boundaries; they can be adapted to various agricultural environments, making them a versatile solution for farmers worldwide.Conclusion: Automating Part of the Agricultural ProcessHada's development of autonomous robots for orchard pesticide application is a promising advancement in the agricultural sector. By addressing the challenges of labor-intensive pesticide application, these robots offer a safer, more efficient alternative that benefits both farmers and the environment. As the technology continues to evolve and expand into new markets, it holds the potential to revolutionize agricultural practices, ensuring a more sustainable future for food production globally. The journey of these robots, from conception to market launch, underscores the importance of innovation in tackling the pressing issues faced by modern agriculture.Interview by Scott Ertz of F5 Live: Refreshing Technology.Sponsored by: Get $5 to protect your credit card information online with Privacy. Amazon Prime gives you more than just free shipping. Get free music, TV shows, movies, videogames and more. The most flexible tools for podcasting. Get a 30 day free trial of storage and statistics.
Is There a Connection Between the Dead Sea Scrolls and the Nag Hammadi Library? An Interview with Dr. Matthew Goff and Dr. Dylan Burns (Part 1) Professors Matthew Goff and Dylan Burns realized there were some surprising commonalities between the Dead Sea Scrolls and Nag Hammadi Library. Traditionally, these ancient writings are studied separately, despite their modern discoveries around the same time and relatively close locations. With Dr. Goff's expertise in the Dead Sea Scrolls and Dr. Burns' expertise in the Nag Hammadi Library, they could describe why both are so important for an understanding of the evolution of Judeo-Christian religions. This is part one of a two-part series. The second episode in the series will be released on June 4, 2025. Read the book they co-authored, The Dead Sea Scrolls and the Nag Hammadi Codices. It's open source, so it's available for free! Dr. Dylan M. Burns is Assistant Professor of the History of Esotericism in Late Antiquity at the University of Amsterdam. He earned his doctorate in Ancient Christianity at Yale University in 2011, before holding research positions in Copenhagen, Leipzig, and Berlin. Among his books are Apocalypse of the Alien God: Platonism and the Exile of Sethian Gnosticism (2014), Did God Care? Providence, Dualism, and Will in Later Greek and Early Christian Philosophy (2020), and The Dead Sea Scrolls and the Nag Hammadi Codices (2022). Dr. Matthew Goff joined the faculty of Florida State's Religion Department in 2005. He completed an M.T.S degree in 1997 at Harvard Divinity School and finished his Ph.D. at the University of Chicago in 2002. He studied under John Collins and wrote his dissertation on a Qumran text entitled 4QInstruction. His publications focus on the Dead Sea Scrolls and ancient Judaism, and his most recent book is The Apocrypha: A Guide (Oxford, 2024). His current book project is on demons and monsters in ancient Judaism and early Christianity. A written transcript is available here: https://earlychristiantexts.com/dead-sea-scrolls-and-nag-hammadi-library/.
For our solar-capable Feathers, we're going to design a FeatherWing helper board to assist with solar connection and monitoring. To do that, we will want to monitor two voltages (the LiPoly battery and the solar panel) and one current (the panel draw). Traditionally, we've liked using the INA219 and friends—let's see if we can find a voltage/current monitor chip with an I2C interface and at least two monitoring inputs. See the part on DigiKey https://www.digikey.com/short/tmc77hmn ----------------------------------------- Visit the Adafruit shop online - http://www.adafruit.com LIVE CHAT IS HERE! http://adafru.it/discord Subscribe to Adafruit on YouTube: http://adafru.it/subscribe New tutorials on the Adafruit Learning System: http://learn.adafruit.com/ ----------------------------------------- #Ladyada #FeatherWing #SolarProjects
It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: A new Austrailian study aims to prevent type 1, the new twiist pump will integrate with Eversnse CGM as well as Libre, diabetes deaths are down in the US, Dexcom U is looking for college athletes, and more! Find out more about Moms' Night Out Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX A world-first human trial of a drug designed to treat the underlying cause of type 1 diabetes has begun in Australia. University of Queensland researcher Ranjeny Thomas said the experimental drug — dubbed ASITI-201 — was designed to retrain the immune system so it no longer attacks the insulin-producing pancreatic cells, known as beta cells. The drug, given as an injection under the skin, combines fragments of a protein found in the beta cells of people with type 1 diabetes and vitamin D to calm the immune response. She said if effective, the drug would initially be given to patients with type 1 diabetes as soon as possible after diagnosis to preserve remaining pancreatic cells and reduce the amount of insulin needed. But eventually, if screening programs can be developed to pick up people at risk of developing type 1 diabetes, it may be possible to "prevent the progression of the disease altogether". The first in-human trial of 36 participants will test the safety of the drug, but blood tests will also determine the impact of the therapy on a patient's immune system and glucose tolerance. https://www.abc.net.au/news/2025-04-29/type-1-diabetes-drug-trial-auto-immune-disease-science/105223022 XX Diabetes deaths in the U.S. have fallen to some of the lowest rates in years, according to new preliminary figures published by the Centers for Disease Control and Prevention, reversing a surge in mortality that was seen during the COVID-19 pandemic. There were 26.4 deaths per 100,000 people from diabetes, according to early death certificate data for the third quarter of 2024 published this month by the CDC's National Center for Health Statistics. Death rates from diabetes peaked in 2021, according to CDC figures, at 31.1 deaths per 100,000 people for that year. Diabetes was the eighth leading cause of death in 2021. The CDC says the link between COVID-19 and diabetes may be to blame for that increase. "Data show an increase in mortality rates for all people during the COVID-19 pandemic, and research shows that people with underlying conditions, including diabetes, are more likely to become very sick from COVID-19 and have a higher risk of hospitalization and death," Christopher Holliday, head of the CDC's Division of Diabetes Translation, told CBS News in a statement. Holliday added that research shows the pandemic may also have made it harder for Americans to properly manage the disease, ranging from interruptions to physical activity to disruptions to routine medical care diagnosing and treating the disease. https://www.cbsnews.com/news/diabetes-deaths-lowest-levels-years-early-cdc-figures/ XX Big news for the Eversense CGM – they have their first pump partner. Sequel Med Tech says the twist pump will integrate with Senseonics Eversense 365 continuous glucose monitor (CGM). This collaboration would make twiist the first AID system compatible with Eversense 365, the world's first and only one-year CGM. Sequel and Senseonics say they have already started their work to integrate the latest-generation, 365-day implantable sensor with twiist. They expect to make the integrated offering available in the third quarter of this year. This marks the second CGM integration for Sequel, which partnered with Abbott and its FreeStyle Libre platform earlier this year. This week we also got a peek at the packaging and delivery of the twist as the first people posted about wearing it. We'll follow up and learn more about this newest insulin pump in the us. Senseonics, meanwhile, brought the first year-long CGM to market last year, launching Eversense 365 with its global distribution partner, Ascensia Diabetes Care, in October 2024. The system also received clearance as an integrated CGM (iCGM) system, meaning it can work with compatible medical devices. Those include insulin pumps as part of automated insulin delivery systems. https://www.drugdeliverybusiness.com/sequel-senseonics-integrate-cgm-insulin-pump/ XX Medtronic has announced the U.S. Food and Drug Administration (FDA) approval for the Simplera Sync sensor for use with the MiniMed 780G system. With this approval, the MiniMed 780G system now offers more flexibility for users of the company's most advanced insulin delivery system featuring Meal Detection technology with both the Guardian 4 sensor and Simplera Sync sensor. The Simplera Sync is a disposable, all-in-one sensor that requires no fingersticks with SmartGuard or overtape and features a simple, two-step insertion process. It is the company's newest addition to its CGM portfolio, which expands options and provides greater flexibility for users. The MiniMed 780G system's adaptive algorithm automatically anticipates, adjusts, and corrects glucose levels every 5 minutes, 24/7 – working around the clock so users can focus on what matters. It's the only system featuring Meal Detection technology, which detects rising sugar levels and delivers more insulin as needed to help users keep glucose levels in range more often – even when users occasionally forget to dose insulin for snacks or meals or underestimate their carbs. The system uses a “treat to target” approach and flexible glucose targets as low as 100 mg/dL, which, combined with its adaptive algorithm allows it to more closely mirror the glucose levels of someone not living with diabetes. Real-world data of the system shows global users consistently achieve time in range above international targets of 70% when using optimal settings (active insulin time of two hours and 100 mg/dL target glucose). It is also the only system that works with the world's only infusion set that lasts up to 7 days so that users only have to change their infusion set once per week and can experience 96% fewer injections compared to multiple daily injections. “We're committed to driving innovation that makes life easier for those living with diabetes so they can forget about their diabetes as much as possible throughout the day,” said Que Dallara, EVP and president of Medtronic Diabetes. “Our MiniMed 780G system delivers advanced diabetes technology for so many around the world, and we're excited to continue evolving this experience with expanded CGM options —including our Simplera Sync sensor, which we look forward to bringing to people living with diabetes in the U.S.” A limited launch of the Simplera Sync sensor will begin in the U.S. in the fall of 2025. Today, the MiniMed 780G system can be used with the Guardian 4 sensor. Like this:https://med-techinsights.com/2025/04/29/simplera-sync-sensor-for-minimed-780g-now-fda-approved/ XX Front office changes at Insulet.. The former head of Johnson & Johnson's worldwide medtech business, Ashley McEvoy will take over as president and CEO from Jim Hollingshead, who has led Insulet since 2022. In its announcement of the leadership change, Insulet said that Hollingshead and the company mutually agreed to part ways, effective immediately. McEvoy served as worldwide medtech chairman at J&J from 2018 until her departure in late 2023, the culmination of nearly 30 years at the company and several executive roles—including president of its Ethicon division and group chairman of vision and diabetes care. Since then, she has also served as a board member at Procter & Gamble. https://www.fiercebiotech.com/medtech/insulet-taps-former-jj-medtech-head-ashley-mcevoy-be-ceo XX New free mobile game launched this week to make type 1 diabetes onboarding faster easier and less overwhelming. It's called Level One.. created by Level Ex (Powered by Relevate Health), the studio behind award-winning medical games for medical professionals. Level Ex CEO Sam Glassenberg created the game after a – quote - brutal onboarding experience when his daughter was diagnosed five years ago He says It took a year to understand how to manage this disease. So we fixed it. We built a game that can train your brain to do it in a matter of hours." The game is launching in partnership with leading diabetes organizations Beyond Type 1 and Breakthrough T1D Play, who are integrating Level One into their outreach and educational campaigns to support newly diagnosed families worldwide. Download Level One on the App Store: https://apps.apple.com/us/app/level-one-a-diabetes-game/id6739605694 Learn more: https://playlevelone.com https://www.prnewswire.com/news-releases/level-ex-launches-level-one-a-free-mobile-game-to-redefine-type-1-diabetes-onboarding-302440929.html XX Collagen is widely recognized for its role in maintaining healthy skin, but its importance extends far beyond that. As the most abundant protein in the human body, collagen provides essential structure and support to nearly all tissues and organs. Now, researchers at Carnegie Mellon's Feinberg Lab have made a major breakthrough using their novel Freeform Reversible Embedding of Suspended Hydrogels (FRESH) 3D bioprinting technique. This method enables the precise printing of soft, living cells and tissues. Leveraging this technology, the team successfully created the first-ever microphysiologic system, also known as a tissue model, constructed entirely from collagen. This advancement opens new possibilities for studying disease and engineering tissue therapies, including potential treatments for conditions like Type 1 diabetes. Traditionally, small-scale models of human tissue, referred to as microfluidics, organ-on-chip devices, or microphysiologic systems, have been fabricated using synthetic materials such as silicone rubber or plastics. These materials were necessary due to limitations in earlier manufacturing techniques. However, because they are not biologically native, they fail to fully replicate natural tissue environments, restricting their effectiveness in biomedical research and therapeutic development. “Now, we can build microfluidic systems in the Petri dish entirely out of collagen, cells, and other proteins, with unprecedented structural resolution and fidelity,” explained Adam Feinberg, a professor of biomedical engineering and materials science & engineering at Carnegie Mellon University. “Most importantly, these models are fully biologic, which means cells function better.” Building Complex Tissues with FRESH Bioprinting In new research published in Science Advances, the group demonstrates the use of this FRESH bioprinting advancement, building more complex vascularized tissues out of fully biologic materials, to create a pancreatic-like tissue that could potentially be used in the future to treat Type 1 diabetes. This advancement in FRESH bioprinting builds on the team's earlier work published in Science, by improving the resolution and quality to create fluidic channels that are like blood vessels down to about 100-micron diameter. “There were several key technical developments to the FRESH printing technology that enabled this work,” described Daniel Shiwarski, assistant professor of bioengineering at the University of Pittsburgh and prior postdoctoral fellow in the Feinberg lab. “By implementing a single-step bioprinting fabrication process, we manufactured collagen-based perfusable CHIPS in a wide range of designs that exceed the resolution and printed fidelity of any other known bioprinting approach to date. Further, when combined with multi-material 3D bioprinting of ECM proteins, growth factors, and cell-laden bioinks and integration into a custom bioreactor platform, we were able to create a centimeter-scale pancreatic-like tissue construct capable of producing glucose-stimulated insulin release exceeding current organoid based approaches.” https://scitechdaily.com/scientists-bioprint-living-tissues-that-could-revolutionize-diabetes-treatment/ XX Another study showing the blood sugar benefit of walking after a meal. Skeletal muscle plays a central role in glucose uptake. Exercise stimulates glucose transport into muscle cells through insulin-independent pathways, notably through the action of glucose transporter type 4 (GLUT-4), which is responsible for transporting glucose from blood to skeletal muscles.4 This means that even without a robust insulin response, physical activity can facilitate glucose clearance from the bloodstream. These effects also occur without requiring high-intensity exercise, making postprandial walking accessible to a broad range of individuals, including those with limited exercise tolerance. multiple studies show that starting activity within 30 minutes after a meal is optimal. https://www.news-medical.net/health/Walking-After-Meals-Small-Habit-Big-Metabolic-Gains.aspx XX Dexcom brings back Dexcom U for a 4th years. This is a name, image and license program for college athletes with diabetes and includes a nationwide open call for passionate and inspiring college athletes to join its roster. Now through May 23, athletes, coaches, friends and family members can nominate candidates through an online submission. Those selected, along with the eight returning athletes from last year, will be invited to attend the Dexcom U Signing Day Camp this summer, hosted by Dexcom Warrior and Baltimore Ravens tight end Mark Andrews. https://www.hmenews.com/article/dexcom-u-returns-for-fourth-season
Dr. Rohan Garje shares the updated recommendations for the ASCO guideline on systemic therapy for patients with metastatic castration-resistant prostate cancer. He discusses the systemic therapy options for patients based on prior therapy received in the castration-sensitive and non-metastatic castration-resistant settings. He emphasizes personalizing treatment choices for each individual, considering patient-specific symptoms and signs, treatment-related toxicities, potential drug interactions, cost, and access. He also reviews recommendations on response assessment. The conversation wraps up with a discussion of potential future updates to this guideline, as the guideline transitions into a “living guideline” on mCRPC. Read the full guideline update, “Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update”. Transcript This guideline, clinical tools, and resources are available at www.asco.org/genitourinary-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology. Brittany Harvey: Hello and welcome to the ASCO Guidelines Podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges and advances in oncology. You can find all the shows, including this one at asco.org/podcasts. My name is Brittany Harvey and today I'm interviewing Dr. Rohan Garje from Miami Cancer Institute Baptist Health South Florida, lead author on, “Systemic Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: ASCO Guideline Update.” Thank you for being here today, Dr. Garje. Dr. Rohan Garje: Absolutely. Thank you so much for having me, Brittany. Brittany Harvey: And then before we discuss this guideline, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest Policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Garje, who has joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then, to start on the content of this guideline, first, could you provide us an overview of the purpose of this guideline update? Dr. Rohan Garje: Sure. So ASCO has guidelines for prostate cancer and the specific guideline which we have updated for metastatic castrate-resistant prostate cancer was originally published in 2014. It's almost a decade. It's been a long time due for an update. Over the last decade, we have seen a lot of advances in the treatment of prostate cancer, specifically with regards to genomic testing, newer imaging modalities, and also the treatment landscape. Now we have newer options based on genomic targets such as PARP inhibitors, we have radiopharmaceuticals, a newer variant of chemotherapy, and also some specific indications for immunotherapy which were not addressed previously. Because all these advances have been new, it was really important for us to make an update. In 2022, we did make a rapid update with lutetium-177, but these additional changes which we have seen made it an appropriate time frame for us to proceed with a newer guideline. Brittany Harvey: Absolutely. It's great to hear about all these advances in the field to provide new options. So I'd like to next review the key recommendations from this guideline. So let's start with the overarching principles of practice that the panel outlined. What are these key principles? Dr. Rohan Garje: As a group, all the panel members came up with some ground rules: What are necessary for all our patients who are being treated for metastatic CRPC? First, the founding aspect was a definition for what is metastatic CRPC. So we defined metastatic CRPC as castrate level of testosterone with evidence of either new or progressive metastatic disease on radiological assessments or patients who have two consecutive rising PSAs in the setting of existing metastatic disease. We also emphasized on the need for germline and somatic testing for patients with metastatic prostate cancer at an earliest available opportunity because it is critical to select appropriate treatment and also right treatment for patients at the right time. And we actually have a concurrent guideline which addresses what genes to be tested and the timing. The other principles are patients should continue to receive androgen deprivation therapy or undergo surgical castration to maintain castrate level of testosterone. Now the key aspect with these guidelines is personalizing treatment choices. As you can see the evolution of treatment options for prostate cancer, the drugs that were initially developed and approved for prostate cancer were primarily in castrate-resistant settings, but now most of these drugs are being utilized in castrate-sensitive. So, when these patients develop castration resistance, the challenges are there are no appropriate particular drug-specific guidelines they meet. So, it's very important for the clinicians to be aware of what treatments have been received so far prior to castration resistance so that they can tailor the treatment to patient specific situations. In addition, prior to choosing a therapy, it is important for the physicians to consider patient specific symptoms or signs, treatment-related toxicities, potential drug interactions, cost, and also access to the drugs. There may be multiple treatment options available for the patients, but for a patient specific scenario, there may be a drug that may be more promising than the others. So, it is important to tailor the drug choices based on patients' unique circumstances. The panel also recommends to early integrate palliative and supportive care teams for symptom management and also discuss goals of care with the patient as each patient may have unique needs and it's important for physicians to address those concerns upfront in the care. The panel also suggests patients to receive RANK ligand inhibitors such as denosumab or bisphosphonates such as zoledronic acid to maintain the bone strength to prevent skeletal-related events. Finally, I would like to also emphasize this point about the lack of randomized clinical trial data for optimal sequencing of therapies for patients with metastatic CRPC. As I previously alluded, we have taken into account all ongoing clinical trials, prior published data, and came up with a format of preferred drugs based on prior treatments and, I think, by following these several clinical principles which I just mentioned, we can optimally choose and utilize best treatments for patients with metastatic CRPC. Brittany Harvey: Absolutely. These principles that you just outlined are important for optimal patient care, and then I want to touch on one of those things. You talked importantly about the treatments received so far. So in the next set of recommendations, the role of systemic therapy was stratified by the prior therapy received in the castration-sensitive and non-metastatic castration-resistant setting. So starting with what does the panel recommend for patients who are previously treated with androgen deprivation therapy alone in these previous settings and whose disease has now progressed to metastatic castration-resistant prostate cancer? Dr. Rohan Garje: There are multiple treatment options based on prior treatment received. So for patients who received only ADT for their castration-sensitive disease, the panel strongly urges to get HRR testing to check for homologous recombinant repair related changes, specifically for BRCA1 and BRCA2 mutations, because we have three studies which have really shown significant clinical benefit for patients who have BRCA1 and BRCA2 mutations with drugs such as the combination of talazoparib and enzalutamide or olaparib with abiraterone or niraparib with abiraterone. Unless we test for those mutations, we'll not be able to give these agents upfront for the patients. In the HRR testing, if patients have HRR alterations but they are in genes which are non-BRCA, the guideline panel recommends to utilize talazoparib and enzalutamide based combination therapies. Now, if they don't have HRR alterations then there are multiple treatment choices available. It could either include androgen receptor pathway inhibitors such as abiraterone with prednisone. We could also consider docetaxel chemotherapy. The alternate choices for androgen receptor pathways include enzalutamide or the newer agents such as apalutamide and docetaxel. So, as you can see there are multiple options available, but the panel definitely emphasizes to test for HRR testing because this gives patients access to more precision therapies at this point. There may be various scenarios where a unique drug may be available for a specific patient situation. For example, patients who have very limited disease burden and may have one or two metastatic lesions, after a multidisciplinary discussion, targeted local therapies such as radiation or potentially surgery could also be offered. In select patients who have very indolent disease where they are castrate-resistant based on slow rising PSA, low-volume disease or asymptomatic disease can consider sipuleucel-T. And in patients who have bone-only metastatic disease, we could also consider radium-223, which is primarily now utilized for patients who have symptomatic bone disease. Brittany Harvey: Great. I appreciate you reviewing all those options and talking about how important it is to tailor treatment to the individual patient. So then the next category of patients, what is recommended for those who have been previously treated with ADT and an androgen receptor pathway inhibitor and whose disease has now progressed to metastatic castration-resistant prostate cancer? Dr. Rohan Garje: So for patients who received ADT along with an androgen receptor pathway inhibitor, which we consider would be a most common cohort because most patients now in castration-sensitive setting are receiving androgen receptor pathway inhibitor. It was different in the past where five or six years back ADT alone was the most common treatment, but fortunately, with enough awareness and education, treatment choices have improved. Patients are now receiving ADT and ARPI as the most common choice of drug. Once again, at this point the panel emphasizes to consider HRR testing in there is enough data for us to suggest that patients who have alterations in the HRR pathway definitely will benefit with the PARP inhibitor. You know the multiple options, but specifically we speak about olaparib. And then if they are HRR-negative, we prefer patients receive agents such as docetaxel or if they are intolerant to docetaxel, consider cabazitaxel chemotherapy, options such as radium-223, and if they have a specific scenario such as MSI-high or mismatch repair deficiency, pembrolizumab could also be considered. The panel also discussed about the role of a second ARPI agent. For example, if patients progressed on one androgen receptor pathway inhibitor, the second androgen receptor pathway inhibitor may not be effective and the panel suggests to utilize alternate options before considering androgen receptor pathway inhibitor. There may be specific scenarios where a second ARPI may be meaningful, specifically, if alternate choices are not feasible for the concern of side effects or toxicities or lack of access, then a potential ARPI could be considered after progression on ARPI, but the panel definitely encourages to utilize alternate options first. Brittany Harvey: Great. Thank you for outlining those options as well for those patients. So then the next category, what is recommended for patients who have been previously treated with ADT and docetaxel? Dr. Rohan Garje: For patients who received ADT and docetaxel and were never treated with androgen receptor pathway inhibitors, the panel again emphasizes on HRR testing. If they have BRCA1 and 2 mutations, the combination therapies of talazoparib with enzalutamide, olaparib with abiraterone, or niraparib with abiraterone are all good choices. If they don't have BRCA mutations but they have other HRR mutations, the panel suggests to potentially utilize talazoparib with enzalutamide. And if they do not have any HRR alterations, the options could include androgen receptor pathway inhibitors such as abiraterone or enzalutamide. I want to emphasize that these are preferred options, but not the only options. As you can see, there are multiple options available for a particular clinical situation - so the ability of the physicians to access particular combinations, the familiarity of those drugs or the patient's unique situation where they have other medications which can potentially interact with a choice of agents. So I think based on access, based on cost and patients' concurrent illness with potential drug interactions can make one particular combination of therapy better over the other options. Brittany Harvey: Absolutely. That's key to keep in mind that access, contraindications, and cost all play a role here. So then the next set of recommendations. What are the key recommendations for patients who have previously been treated with ADT, an androgen receptor pathway inhibitor, and docetaxel who now have mCRPC? Dr. Rohan Garje: Yes. In this group, the options remain, again, broad. We utilize PSMA imaging here specifically and if they are positive on PSMA imaging, lutetium-177 is a good option. If they do not have PSMA-positive disease on PSMA imaging but if they have HRR alterations, olaparib could be utilized. And if they are negative on PSA imaging, they don't have HRR alterations, then alternate options could include cabazitaxel, radium-223. And if they have MSI-high or deficiency in mismatch repair, pembrolizumab could be utilized in this setting. Brittany Harvey: Thank you for outlining those options as well. So then next the panel addressed treatment options for de novo or treatment emergent small cell neuroendocrine carcinoma of the prostate. What are those key recommendations? Dr. Rohan Garje: Yes. This is a very high unmet need group because there are limited clinical trials, especially prospective clinical trials addressing treatment options for this group. Most of our current guidelines are always an extrapolation from lung small cell cancer based guidelines, but the panel recommends to utilize cisplatin or carboplatin along with etoposide as a preferred choice for this group. Also, an alternate option of carboplatin along with cabazitaxel could be considered for this cohort. The panel also encourages participation in clinical trials. There are numerous trials ongoing now in smaller phase studies and I think it's important for patients to consider these trials as well, because this will give them access to newer agents with potential biological targets. In addition to these agents in specific scenarios or potentially case by case basis, because we don't have prospective data, so we have made it as a select case by case basis to consider adding immunotherapy along with platinum-based chemotherapy followed by maintenance immunotherapy, which is currently a standard of care in small cell lung cancer. But the data is so limited in prostate cancer, so the panel suggested that it has to be a case by case basis only. The alternate options also include lurbinectedin, topotecan, tarlatamab upon progression on platinum-based chemotherapy. Brittany Harvey: Yes. It's important to have these recommendations in these unique situations where there is really a lack of data. So then the final set of recommendations I'd like to cover, what does the panel recommend for how clinicians should assess for response while patients are on systemic therapy and what scans are recommended for this response assessment? Dr. Rohan Garje: Yes. Again, this is another strong emphasis of the panel for global assessment of the patients. Traditionally, patients and physicians per se are heavily reliant on PSA as an accurate marker for response. This is in fact true in earlier phases of prostate cancer either in castrate-sensitive setting or localized prostate cancer setting. But as patients evolve into castrate-resistant, we don't want to heavily rely on PSA alone as a marker of response. The panel suggests to incorporate clinical response, radiological response, and also include PSA as a component, but not just rely primarily on PSA. So the panel also suggests that patients should get a bone scan and a CT scan every three to six months while on treatment to assess for appropriate response or for progression. And now one key important aspect, we are all aware about the evolving role of PSMA-based imaging with several of these new agents that are currently available. We do acknowledge these scans definitely have an important role in the care for patients with metastatic prostate cancer. Currently, the utility is primarily to select patients for lutetium-based therapy and also in situations where the traditional scans such as technitium 99 bone scan or CT scan are equivocal, then a PSMA-based imaging can be helpful. Now we are also aware that there are newer studies coming up, prospective data coming up for the role of PSMA-based imaging for response assessment. We are hoping to update the guidelines if we get access to newer data, but currently we have not recommended the utility of PSMA-based imaging for response assessments. Brittany Harvey: Understood. And I appreciate you describing where there is data here and where there's a lack of data to currently recommend. And we'll look forward to future updates of this guideline. Coming back to – at the start you mentioned how much has changed since the last guideline update. So Dr. Garje, in your view, what is the importance of this update and how will it impact both clinicians and patients with metastatic castration-resistant prostate cancer? Dr. Rohan Garje: The updated guidelines are designed to have a significant impact on clinical practice and also patient outcomes by providing clinicians with a comprehensive evidence-based framework for managing patients with metastatic CRPC. And also, by using these guidelines can make informed decisions, can select therapies tailored to patients' unique genomic status, clinical situation, where they are in the course of the cancer based on what they received previously. Also utilizing these guidelines, we can potentially improve patient outcomes, improve survival, and importantly have efficient use of healthcare resources. Brittany Harvey: Absolutely. We're always looking for ways to improve patient outcomes and survival. I want to wrap us up by talking a little bit about the outstanding questions in this field. So earlier you had mentioned about prospective data to come about PSMA PET scans, but what other outstanding questions are there for patients with metastatic castration-resistant prostate cancer? And what evidence is the panel looking forward to for future updates? Dr. Rohan Garje: We do have now rapidly evolving data specifically about the utility of the radiopharmaceutical lutetium-177 prior to chemotherapy. We are hoping that with newer data we can make some changes to the guideline based on that. We are also looking at newer drugs that are coming up in the pipeline, for example, androgen receptor degraders. We are looking at data that might potentially help based on bispecific T-cell engagers and newer radiopharmaceuticals. So I think in the next few years, we will definitely update all the guidelines again. But this time we are trying to do it more proactively. We are following a newer model. We are calling it as ‘living guidelines' where we are actually utilizing week by week updates where we look at the literature and see if there is any potential practice impacting change or publication that comes up. And we are trying to incorporate those changes as soon as they are available. That way patients and practicing physicians can get the latest information available through the guidelines as well. Brittany Harvey: That's great to hear. Yes, we'll await this data that you mentioned to continuously update this guideline and continue to improve patient outcomes for the future. So Dr. Garje, I want to thank you so much for your time to update this guideline. It was certainly a large amount of recommendations, and thank you for your time today, too. Dr. Rohan Garje: Thank you so much for having me here. And it's always nice talking to you. Brittany Harvey: And finally, thank you to our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/genitourinary-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
In this podcast, we spoke with Nainesh Shah, Sr. Application Engineer, Asahi Kasei Bioprocess America, about how inline buffer formulation and their MOTIV® system offers a more efficient, scalable, and cost-effective approach to buffer preparation. Traditional methods require large storage spaces, pose risks of leakage, and create inefficiencies that can disrupt production. In contrast, inline buffer formulation enables real-time mixing of concentrated ingredients, eliminating storage constraints and allowing for dynamic adjustments based on demand. With benefits like reduced waste, lower costs, and improved regulatory compliance, this technology is streamlining operations while ensuring precision and adaptability. As the industry shifts toward smarter manufacturing solutions, inline buffer formulation is paving the way for the future of pharmaceutical production. How Inline Buffer Formulation is Changing the Industry Nainesh, who has over 40 years in the pharmaceutical industry and six years at Asahi Kasei, highlights the evolution of buffer preparation. "Traditionally, buffer dilution involved a concentrate formulated in advance, which was then diluted with water to achieve the desired solution.” Modern inline buffer formulation transforms this process by enabling real-time mixing of individual components. "Instead of storing pre-made buffer solutions, MOTIV allows for real-time formulation using individual components. The system precisely combines these ingredients on demand, ensuring accuracy and eliminating storage-related inefficiencies," Shah explains. Enhanced Efficiency, Cost Savings, and Waste Reduction The advantages of MOTIV extend beyond storage and formulation flexibility. "With traditional methods, production can be delayed if pre-made buffers aren't readily available. If a change in concentration or formulation is required, additional time is needed for sourcing and preparation," Shah notes. "With MOTIV, you can use a single concentrated solution to create multiple buffer variants by adjusting the dilution ratio. This eliminates the need for multiple pre-concentrated stocks, reducing storage space, waste and increasing efficiency." Cost efficiency is another crucial factor. "Return on investment (ROI) depends on whether the facility has an existing buffer preparation setup or is installing a fresh system. For existing setups, ROI typically takes around two years due to transition considerations. However, for new installations, ROI can be achieved within 1.5 years," Shah states. He adds that Asahi Kasei provides an easy-to-use ROI calculator to help companies assess their financial benefits. Additionally, inline buffer formulation improves sustainability by minimizing waste and reducing the environmental impact of excess buffer storage. By eliminating the need for large buffer stockpiles, facilities can lower their material costs and optimize resource utilization. Scalability and Customization for Diverse Production Needs One of the standout advantages of the MOTIV inline buffer formulation system is its scalability. "Our smallest system supports up to 1,200 liters per hour with three inlets—one for water and two for concentrates like acid, base, or salt solutions. On the higher end, we can scale up to 5,000 or even 12,000 liters per hour, completely customizable with multiple inlets based on customer requirements," says Shah. This flexibility is particularly valuable for pharmaceutical manufacturers with varying production demands. Facilities producing multiple types of buffers can benefit from the system's adaptability, allowing them to switch formulations with minimal downtime. Instead of maintaining separate storage tanks for different buffer types, inline buffer formulation enables dynamic adjustments based on real-time requirements. Addressing Complex Formulations and Space Constraints MOTIV is particularly beneficial for high-volume buffer requirements and complex formulations.
Happiness Solved with Sandee Sgarlata. In this episode, Sandee interviews Eva Scott. In this engaging conversation, Sandee Sgarlata and Eva Scott delve into the intricacies of money mindset and financial strategies. They explore the importance of overcoming childhood blockages related to money, the necessity of keeping money flowing, and the significance of investing wisely. The discussion also touches on real estate trends, the challenges of income versus spending, and the vital role of mindset in achieving financial success. Eva emphasizes the need for courage in financial decisions, the value of seeking help from coaches, and the importance of vulnerability in financial planning. Ultimately, the conversation highlights the purpose of creating value and abundance in life. Guest Bio:Eva Scott has had a stellar 20-year career in Financial Services and continues to innovate, rise and add value in a predominantly male-dominated industry. Beginning in the Mortgage and private loans sector and transitioning into her current line of business as a Financial Strategist and Money mindset coach. Licensed in multiple states, Eva is best at educating and coaching individuals and business owners on innovative Financial concepts such as tax-free retirement strategies, life insurance with living benefits, privately sponsored college savings plans, and Estate planning. Traditionally, retiring has had a bad connotation in American culture, yet transitioning out of the work force does not have to be complicated or scary; one can step into a fulfilling new phase where contributing and staying in your zone of genius is a must while having the peace of mind that one's finances are protected against all scenarios and unexpected risks.Takeaways:Money mindset is shaped by childhood experiences.Money should be viewed as a tool for good, not evil.Investment is crucial for financial growth and freedom.Real estate can be a reliable long-term investment.Income stagnation is a significant issue for many.People often focus too much on cutting expenses instead of increasing income.Having multiple income sources is essential for financial stability.Coaching and mentorship can significantly impact financial success.Vulnerability is key to seeking help in financial matters.Creating value and abundance is the ultimate goal in life.Connect with Eva: Call 770-480-0052 for a free 30 minute consultConnect with Sandee: Website: www.sandeesgarlata.comPodcast: www.happinesssolved.comFacebook: www.facebook.com/coachsandeesgarlataTwitter: www.twitter.com/sandeesgarlataInstagram: www.instagram.com/coachsandeesgarlata
Emulsifiers are a ubiquitous component of the modern food supply, found in everything from salad dressings and dairy products to pastries and sauces. Traditionally regarded as safe by regulatory agencies, emulsifiers play a vital role in enhancing the texture, stability, and shelf-life of countless processed foods. Yet, in recent years, emerging research has prompted a reevaluation of this assumption, raising intriguing questions about whether regular consumption of these additives might have previously overlooked health consequences. Recent epidemiological studies have suggested possible associations between higher emulsifier intake and chronic health issues. Concurrently, mechanistic research has provided some biological pathways through which emulsifiers could disrupt gut health. This episode aims to critically examine the scientific literature surrounding dietary emulsifiers, differentiating credible evidence from speculation, and outlining what can—and cannot—be concluded about their potential risks. Timestamps [01:18] Emulsifiers in food: definition, function, and common uses [05:15] Regulatory approval and traditional safety evaluations [09:32] Epidemiological studies on emulsifiers: nutriNet-santé cohort [14:55] Emulsifiers and cardiovascular disease risk [26:12] Emulsifiers and type 2 diabetes risk [30:01] Emulsifiers and cancer risk [35:05] Mechanistic insights: emulsifiers, gut health, and inflammatory bowel disease (IBD) [47:15] Practical recommendations and clinical implications Related Resources Subscribe to Sigma Nutrition Premium Go to episode page (with study links) Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course
Closing out Series 10 begins with a review of the previous episodes as well as the ABC's of the Principles of Pairing. What is a milk stout? After a thorough tasting session, Jason and Craig talk food pairings. Traditionally we close out a series by talking about Magic Bear Beer Cellar and what's coming up for them. Featuring Eric More Cowbell from SingleCut Beersmiths of Astoria, NY.Visit our website at BuffaloBrewsPodcast.comEmail: buffalobrewsPR@gmail.comFollow us on social media.Instagram: @BuffaloBrewsPodcast Facebook: @BuffaloBrewsPodcastX/Twitter: @BuffaloBrewsPod
Take up your cross, my cross, and follow:ME: OUR LORD JESUS CHRIST.So, if you become a Christian, and you should and I pray that you are, you have one promise from our Lord of what is to come, and that is:PERSECUTION.Of course there is joy, rejoicing, grace, bliss, faith, hope, strength, and so much more when you join forces with, become a disciple of, and fall in love with:JESUS CHRIST.But, there comes with all these positives, the negative of:PERSECUTION.For the most part, the world hates Christianity. Secularists disavow and dislike anything about Jesus. And that leaves secular governments to crack down on Christians, Christianity, and the belief and practice thereof.Take China for example. The Chinese Communist Dictator Xi Jinping has tightened his grip on religious activities in the world's second most populous country. The Chinese Communist Party announced last week that starting May 1, foreign missionaries will be prohibited from sharing their faith or preaching, as well as establishing religious organizations. So, if you are Christian in China, you cannot testify about your faith and belief in Jesus Christ. Nor can you preach the gospel of Jesus Christ. Nor can you establish congregations, churches, or any type of religious Christian organization in China. That to me is simply unbelievable and unacceptable, and it will be for so many Christians in China. Nothing will prevent them from sharing and testifying, nothing. And many will become martyrs, jailed, or even killed-executed for their faith. They will gladly, willingly, and lovingly take up their cross, lay their all on the altar, and count themselves blessed if martyrdom happens, and as a result, they go to their eternal reward. China and the Chinese Communist Party are absolutely brutal.The Chinese Communist Party wants to SINICIZE all religion in China. That is, whatever the Communist Party determines religion to be, will be the only one in China. After May 1, 2025, there will be new regulations, a greater crack-down on all religions, but especially Christianity and persecution will be the new normal.We often think of Russia as the main enemy of the United States. Traditionally, that nation has been just that. But today, the number one threat to democracy and America, is none other than the second most populous country in the world:CHINA.It is becoming a superpower and its military strength, army, navy, marines, and special forces grow every day and becomes the number one threat to America and the world over. It is a nation to be reckoned with and it will be used by the forces of evil to challenge every nation in the world. Small wonder that, whatever we the people may think of the means used by President Trump, he stands up against China knowing this incredible threat which begins with democracy, freedom of speech, the practice of religion, subterfuge and infiltration, spying in America and other countries, none of which will be tolerated by the Trump administration.And the same thing happens in Egypt. We hear little about persecution of Christianity in Egypt, but it exists in large measure. Christians face daily discrimination, harsh restrictions, and constant pressure to hide their faith. And in the world at large, it is estimated that 1 in 7 Christians face harassment, violence, or even death, and in Africa the number of Christians enduring constant PERSECUTION is one in five. PERSECUTION of Christians who have given their entire lives to Jesus Christ is on the rise everywhere as both scripture and our Lord, prophesied. Soon, it will be worldwide and in every nation. Are we ready, are you ready, true believer in Jesus Christ, to face that persecution? The Apostle Paul was beheaded because of his Christian faith. The disciple, Peter, was crucified. James was murdered. John was ostracized to Patmos. The early church, especially under Roman dictator Nero, experienced aggressive persecution. It began at the time of our Lord, and it will continue until the rapture.Are you ready? Ready to lay your all on the altar, and take up the cross of Jesus Christ and stand for Him and your faith when persecution comes at you, are you? I do hope so, for it is a decision none of us have had to make in America, not really, even though there is indeed mild persecution. But the day will come when mild is replaced by aggressive. Then and only then, will you know the strength of your faith and the extent to which you really believe in Jesus Christ.And the same thing now exists in Australia, AUSTRALIA NO LESS! In NEW SOUTH WALES (NSW), newly enacted legislation allows prayer or expression of any religious belief if and only if it is not directed to changing or suppressing an individual's sexual orientation or gender identity. If any would pray in that way that is a crime and punishable by imprisonment. In practice, this law would criminalize anyone who said a prayerful word with regard to sexual orientation or gender. REPENT of such, and off to jail you go.And more, everywhere, and persecution has only just begun. Again, when you are faced with that, aggressively or even passively, are you ready to stand, resist, and to accept persecution, even criminal penalties for your faith, are you?Thankfully however, the younger generation begins more so to TURN TOWARDS RELIGION. That is a first start, but sooner or later, that TURN we do hope turns to Christianity and to the person of Jesus Christ. The very respectful research firm BARNA has found in a nationwide survey that 77% of American teens are interested and even motivated to “continue learning about Jesus throughout the rest of their lives.” That at least is a start but by no means the end. Remarkably 52% of the younger generation said they are very interested in knowing more about Jesus. May it be so.There seems to be, said Barna, an openness and curiosity about spiritual matters among today's teens and young adults, a good thing, but only a start. Many of America's young know the futility of the woke generation and its so-called principles, and hunger for something more, much more. They can only find that in Jesus Christ and I hope they continue to search until such time as HE is found. We the believer should thank God that there is now an openness to Christianity and truth which has not existed for years, and revival is on the horizon. All of that is happening in spite of persecution, in spite of the secular, godless governments which somehow have gotten control as witnessed by what is happening in China, Australia, Egypt, and many other nations. The love of Jesus Christ is the most powerful force on this earth, and it should be our prayer that our teens, our younger generation, in our beloved America finds and experiences that love, and no matter the persecution which may come, and it will, continue searching until they find the ultimate answer:HIM,OUR LORD JESUS CHRIST.
What does the new administration mean for cryptocurrency regulation and the balance of authority between the SEC and the states? Traditionally, Republican-led SECs and financial regulators have favored federal preemption of state authority. Under the Biden Administration, however, many red states invoked their consumer protection powers to challenge federal agency actions and defend federalism. This […]
What does the new administration mean for cryptocurrency regulation and the balance of authority between the SEC and the states? Traditionally, Republican-led SECs and financial regulators have favored federal preemption of state authority. Under the Biden Administration, however, many red states invoked their consumer protection powers to challenge federal agency actions and defend federalism. This panel will explore ongoing state litigation against the SEC over the definition of a security and examine how the evolving federal-state dynamic could shape cryptocurrency regulation.Featuring: Justin Clark, Civil Chief, Kentucky Office of the Attorney GeneralPaul N. Watkins, Managing Partner, Fusion Law PLLCEric Wessan, Solicitor General, Iowa Office of the Attorney GeneralModerator: Katie Biber, Chief Legal Office, Paradigm
Smart Agency Masterclass with Jason Swenk: Podcast for Digital Marketing Agencies
Would you like access to our advanced agency training for FREE? https://www.agencymastery360.com/training How often and effectively do you communicate with clients? What strategies are you implementing to build trust and develop lasting relationships to retain good clients? We all have blind spots in business, and today's featured guest identified one of the most significant ones for business owners is client communication and how messages succeed or fail to get through effectively. He'll share his journey of starting a business with the mission of helping business owners identify and repair communication gaps with clients to forge stronger relationships and discuss how he found his niche. He'll also address common communication blind spots that undermine client relationships and emphasize why agency owners must remember that this is fundamentally a relationship business—one where building connections should precede any sales pitch. Join us for insights into marketing, communication, and the importance of addressing blind spots in both business and life. Tim Riddle is the founder of Discover Blind Spots, a marketing agency that specializes in helping financial advisors uncover and address these blind spots in their marketing and messaging. He shares his journey into the marketing agency world, the origin of his agency's unique name, and how his exploration of blind spots in life led him to identify communication as a critical area where businesses often struggle. In this episode, we'll discuss: Choosing a niche in solving their common blind spots. 2 key elements of client communication. Letting clients have the spotlight to build trust. Subscribe Apple | Spotify | iHeart Radio Sponsors and Resources E2M Solutions: Today's episode of the Smart Agency Masterclass is sponsored by E2M Solutions, a web design, and development agency that has provided white-label services for the past 10 years to agencies all over the world. Check out e2msolutions.com/smartagency and get 10% off for the first three months of service. Choosing a Niche and Solving their Common Blind Spot Tim's agency name, Discover Blind Spots, originated from a book he had written years before contemplating entrepreneurship. In "Blind Spots: What You Don't See Can Hurt You," he explored various cognitive and perceptual gaps people commonly experience. During his research, he found one theme kept coming up: communication failures. With entrepreneurial insight, Tim recognized this widespread communication gap as a potential business opportunity. He launched his venture with an ambitious vision of transforming business owners' careers through improved communication. Despite starting with no clients and no immediate prospects, he couldn't let go of the idea without at least trying. Initially, he started by offering his services for free asking only for positive reviews, aiming to build credibility and visibility. However, the true turning point came unexpectedly during a conversation with a friend who was a financial advisor. During their conversation, Tim inquired about his friend's client relationship management approach and got the typical answer of meeting with them for lunch every once in a while. When Tim learned his friend had approximately 300 clients but had only arranged a handful of lunches that year, he saw an opportunity to fill that communicational gap and offered a tailored solution that included creating content, both video and written that would reflect the advisor's voice and perspective, to authentically communicate and engage with his clients. It was a risk to pivot his focus towards financial advisors, a sector he had not originally planned to target, but it was this very risk that led to the establishment of a successful niche for his agency. Transitioning to Premium Pricing Based on Value While that was his first introduction to what would become his niche going forward, it did not immediately translate into paid work. The relationship with this financial advisor served as a crucial stepping stone rather than a direct revenue source. That milestone came later, as Tim's friend introduced him and recommended him to more potential clients and his opportunities in the sector grew. Once he saw the opportunity to monetize his services, Tim started by charging a modest $500 per project, a common approach among agency owners. Finally, once he landed his first big client, he was asked to come up with a monthly fee and upgraded to charging $5,000 per month. It was a shift to a value-based pricing model most agency owners take too long to adopt and a starting point to truly start scaling the agency. 2 Key Elements of Top-Notch Client Communication We've all experienced customer service that starts strong during the sales process but deteriorates once the purchase is complete. Poor follow-up communication leaves clients with unanswered questions about their purchase, casting a negative shadow over the entire experience. Responsiveness: Tim believes silence is the enemy in client relationships. He says there's never a good reason to allow communication gaps that make clients question the relationship. Likewise, he warns against applying a transactional mindset to a relationship-driven business. This only serves to frustrate clients and lead to missed opportunities. Being responsive doesn't mean having immediate answers or dropping everything to find them. Often, a simple acknowledgment that you don't have the information yet but are working to get it promptly can significantly reassure clients. Adaptability: Another key aspect of Tim's approach is identifying each client's preferred communication channel early in the relationship. People have different preferences—some avoid phone calls and find emails to be less intrusive while others prefer them as a quicker way to solve an issue. By adapting to the client's preferred mode of communication, agencies can save considerable time and stress. Interestingly, if you're attentive, clients often reveal their communication preferences through their behavior without you having to ask directly. For instance, if a client rarely responds to emails but answers calls promptly, they likely prefer handling matters quickly by phone. Taking the extra effort to communicate in a style that resonates with each client leads to faster resolutions and more productive partnerships. Allowing Clients to Have the Spotlight Leads to Trust & Effective Communication Tim's efforts to adapt to clients have extended beyond just communication channels to improve the overall client experience, particularly during initial meetings. Traditionally, he would schedule two-hour sessions packed with questions, aiming to leave with a comprehensive 90-day action plan. More recently, however, he began to start the meeting by asking the client “tell me a little about yourself”. This can lead to a 5-minute summary or a 30-minute account of their business' history but Tim finds letting the client feel heard helps out them at ease and leads to smoother more amicable meetings. As an expert, you might quickly identify solutions to a client's problems within minutes of meeting them. However, rushing to provide answers won't help establish the trust necessary for a successful partnership. Building that sense of safety requires patience—sitting back and truly listening as clients share what they believe is essential information. This approach enables them to feel confident that you have a complete understanding of their situation before developing an action plan. People have a fundamental desire to be understood. By creating space for clients to share their stories and experiences, businesses can cultivate meaningful trust and rapport that serve as the bedrock for successful long-term relationships. Do You Want to Transform Your Agency from a Liability to an Asset? Looking to dig deeper into your agency's potential? Check out our Agency Blueprint. Designed for agency owners like you, our Agency Blueprint helps you uncover growth opportunities, tackle obstacles, and craft a customized blueprint for your agency's success.
Read OnlineThe Savior of the World died a cruel death upon the Cross. His broken body was laid in the tomb. His disciples scattered and were fearful that they would be next. But our Blessed Mother kept vigil in the perfect hope that her Son would soon rise.Traditionally, Saturdays within the Church year are dedicated to the Blessed Virgin Mary. This ancient tradition developed in part due to the belief that, as others were filled with fear and confusion, Mother Mary kept vigil on Holy Saturday in prayerful anticipation of Jesus' resurrection. She knew her Son would rise. She had hope beyond hope. Her faith was certain. Her love kept her vigilant as she awaited the return of her Son.For many centuries, it has been suggested that the first person to whom Jesus appeared after His Resurrection was His own mother. Pope Saint John Paul II believed this. Saint Ignatius of Loyola believed it. And many others throughout the centuries shared this belief.For these reasons, Holy Saturday is an ideal day to ponder the pondering heart of our Blessed Mother. There are several times in Sacred Scripture where we are told that Mother Mary pondered the mysteries of her Son's life in her heart. She was one of the few who stood by Him in His agony and death. She stood before the Cross and prayerfully pondered His perfect sacrifice. The Blessed Mother held His dead body in her arms and pondered where His spirit had gone. And today she keeps vigil, pondering His imminent return to her.Ponder her pondering heart. Try to unite your own heart with hers. Try to understand what she was thinking and hoping. Try to feel what she felt this sorrowful day. Try to experience her faith, her trust and her joyful expectation. So many people in this world walk in despair and confusion.So many have lost hope in the new life that awaits them. So many have their own form of interior death without allowing God to draw them into His Resurrection. So many people today need the hope that was so alive in the heart of our Blessed Mother that first Holy Saturday. Ponder the reality of Holy Saturday in silence this day and allow the glorious heart of our Blessed Mother to inspire you and draw you more deeply into her life of faith, hope and love.Dearest Mother Mary, on that first Holy Saturday, you kept vigil for your Son. You allowed the divine gift of hope to grow within you, and you allowed that hope to be your strength in the midst of the horror of the Cross. Pray for me that I may ponder your beautiful heart this day so that I, too, may be filled with hope as I endure the challenges of this earthly life. Give me a heart of joyful anticipation as I await the grace of new life our Lord so deeply desires to bestow upon me. Mother Mary, pray for me. Jesus, I do trust in You. Guercino, Public domain, via Wikimedia CommonsSource of content: catholic-daily-reflections.comCopyright © 2025 My Catholic Life! Inc. All rights reserved. Used with permission via RSS feed.
Welcome to a bonus episode of The Times of Israel's newest podcast series, Friday Focus. Each Friday, join diplomatic reporter Lazar Berman and host deputy editor Amanda Borschel-Dan for a deep dive into what's behind the news that spins the globe. In today's episode, environment reporter Sue Surkes makes a guest appearance, stepping in for Berman. This is a week of spring holidays, and so we are dedicating the program to some of the biblical flora of the Land of Israel. In honor of Easter, which is celebrated by much of Christendom on Sunday, we begin with a date palm that was brought back from the dead and a plant that resurrects itself. In 2008, Dr. Elaine Solowey germinated a 1,900-year-old date palm seed that took the name Methuselah after the long-lived biblical character. She has since gone on to revive several more ancient seeds, including females that bear fruit. Surkes tells the story of Solowey's amazing success -- and describes how the dates taste. Next, we hear about the Rose of Jericho, which was named for the biblical city of Jericho that constantly rose from its ashes -- and still stands today. It's an extraordinary story of a plant surviving in the harshest of circumstances. We then turn to a tree that is called the Christ-thorn jujube (shezaf). Traditionally, this type of tree was used to create the thorny crown that Jesus wore on his last journey down the Via Dolorosa. Surkes then speaks about the olive tree -- both the last few remaining "wild" variety located near Atlit, and the cultivated variety. She turns to Psalm 128 to show how being acquainted with the flora of the Land of Israel gives a deeper meaning to the text. And finally, we speculate on the Garden of Eden's "forbidden fruit." Was it an apple? Or maybe a fig? Friday Focus can be found on all podcast platforms. This episode was produced by the Pod-Waves and the video was edited by Thomas Girsch. IMAGE: Dates harvested from 'Hannah,' the first female palm tree germinated from 2,000 year-old seeds discovered in the Judean desert, are displayed in Kibbutz Ketura in southern Israel, on September 27, 2021. (Emmanuel DUNAND / AFP)See omnystudio.com/listener for privacy information.
At first glance, authors and entrepreneurs might seem like they live in separate worlds. But they are more connected than you might think. Traditionally, books have been treated as stand-alone works, limiting their potential impact. Out of the 11,000 books published every day, only about 1,000 make over $1,000 a year. But what if your book could do more than sit on a shelf? What if it could spark a movement, create consistent income, and build the foundation of a thriving business? In this episode, we're diving into how your book can be the blueprint for your brand, the manifesto of your mission, and the seed that grows into a profitable platform. For Black entrepreneurs, who often face barriers to capital, mentorship, and visibility, authorship can be a powerful form of ownership and authority. That's why we're joined by Taurea Avant, a graduate of Hampton University, a two-time TEDx speaker, and the Queen of Book Profiting. She has helped over 6,000 speakers and coaches become published authors and turn their books into multiple streams of income. In this masterclass style episode, she walks you through the exact steps to go from book to business while giving you the tools to scale your impact along the way. DURING THIS EPISODE YOU'LL LEARN: Why most books don't generate real income and how to change that The mindset shift needed to go from author to entrepreneur How to turn chapters from your book into offers, services, or experiences What systems and tools you need to run a book-based business How to use your book to land speaking opportunities and media features Why your book should be a core part of your brand, not just a side project Don't miss out on the resources mentioned in this episode by checking out the show notes at blacktobusiness.com/248 Thank you so much for listening! Please support us by simply rating and reviewing our podcast! Got a question? We'd love to answer it in an upcoming Q&A. Simply record your quick question → https://blacktobusiness.com/QA Connect with us on Instagram: https://www.instagram.com/blacktobusiness/ Don't miss an update! Sign up for our weekly newsletter: https://blacktobusiness.com/mailinglist
This week on EYE ON NPI we're looking at a bright and sunny new product, this week it's the Vishay VEML6046X00 RGBIR Color Sensor (https://www.digikey.com/short/t3jhhdt1) an inexpensive way to add RGB + IR sensing with I2C to your next product. This sensor is the latest from Vishay, well known for their light sensing expertise, and requires no lenses or filters to get started immediately. We've used lots of Vishay sensors in our breakout boards (https://www.adafruit.com/search?q=vishay) so we know they are experts in light sensors, in our experience their products are reliable and easy to use with I2C interfaces that hew closely to the I2C/SMBus specifications without funkiness like clock-stretching or auto-sleep modes. This is the first time we're looking at an RGBIR sensor from them. Traditionally we've leaned on them for infrared or 'clear' light sensing. As expected, the chip contains 4 diode sensors, tuned for red, green, blue and IR light. The sensors are fairly well normalized and characterized, with red at 90% and blue at 70% spectral sensitivity compared to green. What we thought was particularly useful about the VEML6046X00 is it comes with a Lux conversion table - and the Lux ranges up to 176 klux! This is great because it means it won't saturate out even in direct sun, reflected or directed light that would normally be considered 'blinding'. This is the highest lux sensor we've seen since the discontinued MAX44009 (https://www.digikey.com/en/products/detail/analog-devices-inc-maxim-integrated/MAX44009EDT-T/2606393) which was the previous max of 188 klux. This sensor would be a good alternative with minimal work required to 'port' the firmware over. Speaking of firmware, the sensor communicates over I2C, much like most light sensors that don't need high speed. There's also an IRQ pin out for automatically triggering when going over or under a light level. The I2C register map is blessedly short, and there's an ID register so you can be sure you have the right sensor connected. Otherwise it's fairly similar to the other sensors we've used: you can probably whip up a library to do readings in a day or two - check Vishay's app note for integration for extra tips on how to initialize and read sensor data (https://www.vishay.com/docs/80410/designingveml6046x00.pdf) Or you can use Vishay's VEML6046X00 software library (https://www.vishay.com/docs/80546/veml6046x00_software_libraries.zip). Intrigued? You can pick up the Vishay VEML6046X00 RGBIR Color Sensor (https://www.digikey.com/short/t3jhhdt1) from DigiKey right now! It's in stock and tariff-free which makes it a great deal for a quality RGBIR lux sensor. We're also going to be looking at turning this into a breakout board. Until then, order now for immediate delivery, so you can spend more time in the sunshine and less time adding lux and color sensing to your next product.
Are today's endless wars a departure from the classical model of victory through total defeat and political transformation? Or have we simply lost the will to wage decisive wars? “ Traditionally, the way that political differences were settled—the aggressor versus the invaded—was by defeating the enemy through superior force. “ These conflicts are what we call a “bellum interruptum,” they just keep going on. They simmer down, they flare up like a forest fire. But the old classical idea that you defeat the enemy, you solve the political problem may not be as ossified as we think. 00:00 Introduction: Reflecting on the Nature of War 00:56 Historical Perspective: Classical Warfare 02:36 Modern Conflicts: The Shift in Warfare 04:12 Case Studies: Middle East and Ukraine 06:06 Conclusion: The Future of Warfare
Are today's endless wars a departure from the classical model of victory through total defeat and political transformation? Or have we simply lost the will to wage decisive wars? “ Traditionally, the way that political differences were settled—the aggressor versus the invaded—was by defeating the enemy through superior force. “ These conflicts are what […]
This episode begins with the idea that in traditional cultures worldwide the search for wisdom would be a necessity for developing genuine leadership. It would also be a primary practice for those who would become elders. Genuine elders were considered a valuable living resource, without whose guidance entire societies could become trapped in short term thinking, mired in materialistic aims and in danger of entirely losing their way. Traditionally, elders lead by remembering further back than others and by seeing more clearly ahead. Although growing older can involve a loss of short term memory, elders remember the essential values and the enduring truths that people keep forgetting. Thus, they are less likely to be strictly political leaders and more likely to be cultural and spiritual guides. In this archetypal sense, elders serve as seers who can see behind and beyond the politics of the day, and perceive more accurately the needs of the future. The passing of time makes everyone older, but not necessarily wiser. The qualities needed to be a true elder involve more than physical changes. There is something metaphysical, psychological and spiritual involved. As William Blake put it, "Wisdom combines insight with experience and vision with maturity. If maturity expands vision, it leads to wisdom. And if it does not, maturity simply becomes degeneration." As someone else once said, "You are only young once, but you can stay immature indefinitely." The archetype of the elder exists in the depths of each person's soul where it is connected to the deepest ideals of humanity. When the world becomes dark and foreboding and even the future of life on Earth becomes uncertain, the inner elder and wise sage can awaken in each of our souls. When that kind of awakening occurs, something ancient and enduring, something visionary and creative can enter the world through us and provide the wisdom we most need. Thank you for listening to and supporting the Living Myth Podcast. You can further support this podcast by becoming a member of Living Myth Premium. Members receive bonus episodes each month, access to the full archives of nearly 700 episodes and a 30% discount on all events, courses and book and audio titles. Learn more and join this community of listeners at patreon.com/livingmyth. If you enjoy this podcast, we appreciate you leaving a review wherever you listen and sharing it with your friends. On behalf of Michael Meade and the whole Mosaic staff, we wish you well and thank you for your support of our work.
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