Podcasts about mitochondrial health

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Best podcasts about mitochondrial health

Latest podcast episodes about mitochondrial health

Salad With a Side of Fries
The Next Frontier Files: New Doors, Your Choice (vol. 3)

Salad With a Side of Fries

Play Episode Listen Later Sep 2, 2026 24:54 Transcription Available


Personalized wellness is reshaping the entire health conversation, and this new The Next Frontier Files episode proves the old rulebook is officially closed for good. From psychedelics and genetic testing to women's health investment and metabolic health, expert guests from year three of Salad with a Side of Fries reveal the trends that would become some of the biggest wellness breakthroughs, long before the headlines ever catch up.Host Jenn Trepeck shares the ideas from year three of Salad with a Side of Fries, revisiting the boldest predictions, the holistic health conversations, and the recurring threads that shaped where wellness was headed next.What You Will Learn in This Episode:✅ Why the future of health is built on personalized nutrition and genetics rather than one-size-fits-all rules✅ How psychedelics and microdosing are entering the mainstream conversation around consciousness and healing✅ Why metabolic health is being named as the true root cause behind most chronic disease✅ How accessible wellness and honest food conversations are becoming the next big shift in the industryThe Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into real-life wellness and weight loss, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 A preview of year three, covering psychedelics, genetics, women's health, and personalized wellness03:59 Alexander Carter suggests looking at the individual and questions following the wellness rules05:03 Daniel Sanders and Peter Reitano discuss psychedelics, consciousness, and life extension research07:17 A raw, unscripted mental health conversation shows instead of tells during Awareness Month08:32 Dr. Lisa Oldson connects genetic testing and artificial intelligence to future personalized nutrition09:57 David Frost on gene editing, BRCA, and the ethics of enhancement technology11:20 Sophia DeSantis shares her fertility story and why alternative medicine and modern care can coexist12:23 Marie Van Blerkom exposes the shocking lack of female health companies on the stock exchange13:42 Erica Stein and Aly French challenge food inequality and call for truly accessible wellness15:35 Guests discuss trauma, anti-aging, longevity and aging well17:34 Hope Pedraza links gut health work to spirituality, human design, and total wellness18:28 Dr. Mariza Snyder names metabolic health as the real root cause behind most chronic disease19:54 Justine Ang Fonte hopes the next wellness frontier is genuine body affirmation over profit-driven trends20:20 Jenn ties up her thoughts on year threeKEY TAKEAWAYS:

UNPILLED Podcast
Healing at the Cellular Level with Dr. Will Cole

UNPILLED Podcast

Play Episode Listen Later Sep 2, 2026 65:28


What if chronic disease isn't primarily an organ problem, but a cellular one?In this episode, Dr. Will Cole joins Justin Harris to explore the emerging science of cellular health and longevity. Dr. Will Cole is a leading functional medicine practitioner, New York Times bestselling author, and host of The Art of Being Well podcast. They sit down to discuss his latest book, Heal Your Cells: Reversing the Irreversible, co-authored with Dr. Josh Axe. Together, they explore why cellular dysfunction may be the true root of chronic disease, how lifestyle and environment shape our health trajectory, and why longevity is about more than simply extending lifespan.If you wish to learn more from Dr. Will Cole, you can do so through the following links:Visit his website at https://drwillcole.com/ Podcast: The Art of Being WellPre-order Dr. Cole's book now at https://thehealthinstitute.com/products/heal-your-cells and get bonuses before it releases on September 8th!______________________________________________________Keep yourself up to date on The DNA Talks Podcast! Follow our socials below:The DNA Talks Podcast Instagram: @dnatalkspodcastThe DNA Company Instagram: @thednacoThe DNA Company's Official Tiktok Account: @thednaco3Justin's Instagram Account: @justinharrisofficialMedical Disclaimer:  The information provided in this communication is for general informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read here. If you think you may have a medical emergency, call your doctor or 911 immediately.

The Lisa Fischer Said Podcast
Which Supplements Do You Really Need? Dr. Luke Bucci Reveals the Big 3

The Lisa Fischer Said Podcast

Play Episode Listen Later Aug 25, 2026 36:53


Mitochondrial Health and Cellular Aging may sound complicated, but could better health really start with just three essential supplements?     In this episode of the Lisa Fischer Said Podcast, Lisa Fischer sits down with supplement expert and clinical nutritionist Dr. Luke Bucci to break down the foundational supplements he believes can provide the most benefit: vitamin D3, omega-3s, and magnesium.     Dr. Bucci explains why vitamin D matters far beyond bone health, how vitamin K2 fits into the picture, and why testing your vitamin D levels can help you make smarter decisions. He also reveals why he prefers krill oil over traditional fish oil, how to recognize rancid omega-3s, and what makes omega-3 phospholipids so important.     The conversation also explores magnesium forms, magnesium-rich foods, calcium supplementation, bone remodeling, gut health, plant foods, polyphenols, and the connection between nutrition and healthy aging.    

The Better Life with Dr. Pinkston Podcast
Cognitive Health Breakthroughs, Ginsenosides & Thyroid Health Regulations

The Better Life with Dr. Pinkston Podcast

Play Episode Listen Later Aug 22, 2026 36:20


In this episode of The Better Life with Dr. Pinkston, host Dr. Mary Ann Pinkston sits down with pharmacist Ray Solano from PD Labs to discuss cutting-edge integrative science and brain health solutions. They explore the neuro-regenerative properties of RG3 and RB1 ginsenosides, how nasal spray formulas are helping combat cognitive decline, and the role of Alpha-GPC and nicotinamide riboside in mitochondrial energy. Additionally, Dr. Pinkston and Ray break down critical updates regarding thyroid glandular availability, compounding pharmacy benefits, and off-label therapeutic solutions like VIP nasal spray for pulmonary hypertension and CIRS. Learn more about PD Labs: pdlabsrx.com Explore past episodes and resources with Dr. Pinkston: drpbetterlife.comSee omnystudio.com/listener for privacy information.

Super Woman Wellness by Dr. Taz
Dr. Zach Bush: How the Microbiome Affects Metabolism, Brain Health, and Chronic Disease

Super Woman Wellness by Dr. Taz

Play Episode Listen Later Aug 13, 2026 74:34


Join The Circle and use code "PODCAST": https://holplus.co/circle/ What if chronic disease, declining energy, cognitive issues, and fertility challenges are not isolated problems, but signs of a deeper disconnection from the natural world?In this episode of hol+ with Dr. Taz MD, Dr. Zach Bush explores the relationship between human health and the health of our environment. Drawing from his background in internal medicine, endocrinology, cancer research, and hospice care, he explains how his search for the root causes of disease led him from the hospital and laboratory to the microbiome, soil science, and regenerative agriculture.Dr. Bush describes mitochondria as essential generators of cellular energy and explains how the microbes living within and around us help support metabolism, immunity, neurological function, and communication throughout the body. He shares his perspective on how chemical agriculture, declining biodiversity, and changes in our food systems may be affecting these biological relationships.Dr. Taz and Dr. Bush also discuss the rise of obesity, insulin resistance, autoimmune disease, cognitive decline, chronic fatigue, and infertility. Dr. Bush presents his theory that these conditions may be connected through a broader decline in metabolic energy and our increasing separation from nature.The conversation ultimately turns toward hope and practical action. Dr. Bush explains why restoring soil, supporting regenerative farmers, growing food, strengthening local communities, and spending more time in direct contact with nature may help rebuild both human and planetary health. He also shares how something as simple as growing a mint plant can begin restoring a family's relationship with living food.In this episode:Dr. Bush's journey from conventional medicine to microbiome and soil researchWhat mitochondria do and why they are essential for cellular energyHow the microbiome influences metabolism, immunity, and brain functionThe relationship between soil health, food quality, and human healthHow chemical agriculture may disrupt biological communicationWhy Dr. Bush describes modern illness as nature deficit disorderHis theory connecting metabolic decline with chronic disease and fertilityWhy supplements cannot fully replace a healthy food systemHow regenerative agriculture can support human and planetary healthSimple ways to reconnect your family with food, soil, and natureWhy community and human connection may be essential parts of healingAbout Dr. Zach Bush:Dr. Zach Bush is a triple board-certified physician specializing in internal medicine, endocrinology and metabolism, and hospice and palliative care. His work has focused on the relationships between the microbiome, human health, environmental health, food systems, and regenerative agriculture. After years of working in conventional medicine and biomedical research, Dr. Bush began exploring how soil health, biodiversity, and chemical exposure may influence human metabolism and chronic disease. His work helped give rise to Project Biome and Farmer's Footprint, initiatives focused on regenerative food systems and restoring the relationship between human and planetary health.Connect with Dr. Zach Bush:https://zachbushmd.com/https://www.instagram.com/zachbushmd/https://farmersfootprint.us/About Dr. Taz:Dr. Tasneem Bhatia (Dr. Taz) is a triple board-certified integrative medicine physician, bestselling author, and founder of hol+, a multi-location integrative medicine practice.Learn more: https://doctortaz.com/aboutStay Connected:Connect further with hol+ at https://holplus.co/ and don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Book a Hol+ Consultation:https://holplus.co/locations/virtual/Follow Dr. Taz on Instagram:https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Subscribe to the audio podcast:https://holplus.transistor.fm/subscribeSubscribe to the video podcast:https://www.youtube.com/@DrTazMD/podcastsProduced by https://ClipGrowth.com (Producer: Pat Gostek)

NASM Master Instructor Roundtable: A Show for Personal Trainers
Zone 2 Cardio Benefits for Longevity & Brain Health

NASM Master Instructor Roundtable: A Show for Personal Trainers

Play Episode Listen Later Aug 11, 2026 40:30


Are you skipping the most important cardio zone without even knowing it? In this episode of the “Master Instructor Roundtable,” NASM Master Instructors Marty Miller and Wendy Batts reveal why Zone 2 cardio is the real game-changer for anyone looking to boost fitness, brain health, and longevity—no matter your age or athletic level! What You'll Learn in This Episode: Zone 2 Cardio Explained: The science and benefits behind moderate-intensity steady-state exercise How to Accurately Test Your Cardio Zones: Practical insights on VT1, VT2, talk tests, and why old-school formulas don't work Mitochondrial Health & Longevity: How steady-state cardio regenerates your body at the cellular level and supports lifelong independence Brain Benefits: Discover BDNF, the “Miracle-Gro” for your brain, and how the right cardio can transform mental sharpness Programming for Results: Evidence-based strategies and protocols you can apply instantly, with treadmill, bike, rower, and more Debunking Cardio Myths: Why “more is better” thinking can actually stall your progress Whether you're a personal trainer, health enthusiast, or just want to stay active and independent as you age, this episode is packed with research-backed advice and actionable tools to help you get the most out of every workout! Show References:Meixner,B., Filipas, L., Holmberg, H., Sperlich, B. (2025). Zone 2 intensity: A critical comparison of individual variability in different submaximal exercise intensity boundaries. Translational SportsMedicine, Article 2008291.   https://doi.org/10.1155/tsm2/2008291Sutton, B. (2021). NASM essentials of personal fitness training (7th ed.). Jones & Bartlett Learning. Sorenson, E. (2021, August 25). Master instructor roundtable: Five stages of cardiorespiratory training [Video]. YouTube. https://www.youtube.com/watch?v=6uvq-8KSr3s Sorenson, E. (2021, September 10). Master instructor roundtable: An in-depth look at cardio assessments [Video]. YouTube. https://www.youtube.com/watch?v=JorphuGKU8g Ramos-Jiménez, A., Rubio-Valles, M., Ramos-Hernández, J. A., González-Rodriguez, E., & Moreno-Brito, V. (2025). Adaptations in mitochondrial function induced by exercise: A therapeutic route for treatment-resistant depression. International Journal of Molecular Sciences, 26(17), Article 8697. https://doi.org/10.3390/ijms26178697 Sitko, S., Artetxe, X., Bonnevie-Svendsen, M., Galán-Rioja, M. Á., Gallo, G., Grappe, F., Leo, P., Mateo, M., Mujika, I., Sanders, D., Seiler, S., Zabala, M., Valenzuela, P. L., & Viribay, A. (2025). What is zone 2 training?: Experts' viewpoint on definition, training methods, and expected adaptations. International Journal of Sports Physiology and Performance, 20(11), 1614-1617. https://doi.org/10.1123/ijspp.2024-0303 If you like what you just consumed, leave us a 5-star review, and share this episode with a friend to help grow our NASM health and wellness community!  The content shared in this podcast is solely for educational and entertainment purposes. It is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek out the guidance of your healthcare provider or other qualified professional. Any opinions expressed by guests and hosts are their own and do not necessarily reflect the views of NASM.  Introducing NASM One, the membership for trainers and coaches. For just $35/mo, get unlimited access to over 300 continuing education courses, 50% off additional certifications and specializations, EDGE Trainer Pro all-in-one coaching app to grow your business, unlimited exam attempts and select waived fees. Stay on top of your game and ahead of the curve as a fitness professional with NASM One. Click here to learn more. https://bit.ly/4ddsgrm

Everyday Wellness
BONUS: Mitochondria and Cellular Aging with Dr. Siobhan Mitchell | Menopause, Perimenopause, Mitochondrial Health

Everyday Wellness

Play Episode Listen Later Aug 10, 2026 76:09


In this episode, we're featuring MitoQ, a company whose research around antioxidant support for mitochondrial function has been of particular interest to me. I'm thrilled to welcome Dr. Siobhan Mitchell, the Chief Scientific Officer at MitoQ. Dr. Mitchell completed her PhD at SUNY Albany and a postdoctoral fellowship on brain aging at the University of Washington. She has held roles at multinational food companies, leading research on brain nutrition, metabolism, cardiovascular health, and weight loss. She has published clinical research demonstrating the effects of stress on women's heart health and the importance of nutrients such as polyphenols, omega-3s, probiotics, and amino acids for brain health, authored dozens of clinical studies and more than 80 papers, and given talks on nutritional neuroscience at conferences worldwide. She also holds eight patents for products related to aging, cognition, and mood. In today's conversation, Dr. Mitchell and I discuss mitochondrial physiology, energy, and dysfunction, exploring the impact of MitoQ and supplementation for supporting health. We examine research on menopause, how estrogen influences mitochondria, the roles of oxidative stress, antioxidants, and zombie cells, highlighting how mitochondria impact our cardiovascular health, the value of MitoQ in supporting vascular function in females, the importance of polyphenols and spices, and signs of mitochondrial dysfunction. This is a truly invaluable conversation- one you'll likely want to revisit. Stay tuned for today's informative discussion on supporting our mitochondria and reducing oxidative stress with MitoQ. IN THIS EPISODE, YOU WILL LEARN: How our mitochondrial function changes as we get older, and what those changes might look like How antioxidants protect the mitochondria from free radicals and oxidative stress The early signs of mitochondrial dysfunction  How women who have damaged their mitochondria earlier in life can proactively support their mitochondria Why some oxidative stress may be beneficial and when it could become problematic How mitochondrial dysfunction impacts heart function, blood glucose regulation, insulin resistance, and metabolic syndrome What Dr. Mitchell recommends for women learning about mitochondrial support for the first time Dr. Mitchell shares the daily practices she uses to support her brain and metabolic health. How long you may need to take MitoQ before noticing improvements, and what those improvements might look like Bio: Dr. Siobhan Mitchell Siobhan Mitchell is the chief scientific officer of MitoQ. She completed her PhD at SUNY Albany and a post-doctoral fellowship on brain aging at the University of Washington. Siobhan has held roles at multinational food companies leading research on brain nutrition, metabolism, cardiovascular health and weight loss. Siobhan has published clinical research showing the effects of stress on women's heart health, and the importance of nutrients such as polyphenols, omega-3 oils, probiotics and amino acids for brain health. She has authored over a dozen clinical studies on best practices for weight management and prevention of chronic diseases during her time as senior director for Noom. Siobhan is passionate about the intersection of nutrition and lifestyle factors, such as exercise, sleep, and mental well-being, to extend health span. Siobhan has given talks on nutritional neuroscience at conferences all over the world. She's authored over 80 papers and holds eight patents for aging, cognition, and mood products. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Siobhan Mitchell MitoQ  The Mitochondrial Collaborative Research Programme (MCRP)  Email Dr. Siobhan Mitchell: s.mitchell@mitocq.com

Intelligent Medicine
Intelligent Medicine for August 8, Part 2: Your Future Drug Deliveries May Be Via Drones

Intelligent Medicine

Play Episode Listen Later Aug 10, 2026 35:23


LTC University Podcast
From Guesswork to Precision: How Peptides Actually Get Prescribed

LTC University Podcast

Play Episode Listen Later Aug 10, 2026 33:10


What if the peptide you just ordered online isn't wrong — it's just wrong for you? In Episode 2 of our peptides series, clinical pharmacist Dr. Melissa Jones takes us inside the actual decision-making process providers use to match a peptide to a patient, and why skipping that process is how people end up wasting money, or worse, hurting themselves. Host Jamie Preston and Dr. Jones dig into the real science: what a peptide is, how peptides signal the body, and why a healthy foundation — hormones and gut health — has to come before any peptide is even considered. From there, they cover the wide menu of options (tissue repair, skin and hair, sexual health, growth hormone support, metabolic health, sleep and stress) and what it actually means to “stack” or “cycle” peptides responsibly. In this episode, you'll hear: Why there isn't — and won't be — one peptide that does it all, and what that means for how providers build a plan How stacking and cycling actually work, and where cost becomes a real factor in the decision The difference between FDA-approved peptide uses (like Tesamorelin for visceral fat) and the anecdotal dosing happening across the wellness world The real danger in reconstituting and self-dosing peptides ordered online, explained in plain terms What responsible, supervised GLP-1 (Mounjaro, Ozempic, tirzepatide) therapy looks like — and what goes wrong with compounded, unregulated versions The specific list of patients who should avoid peptides or use extra caution, and why providers need to know it cold If you've ever wondered whether a peptide could actually help you — or wondered what your provider is really weighing before saying yes — this episode gives you the real answer, not the Instagram version. www.YourHealth.Org

Not Another Fitness Podcast: For Fitness Geeks Only
Episode 399: Urolithin A, Mitochondrial Health, and Nutrition for Pro Athletes — Dr. Emily Werner

Not Another Fitness Podcast: For Fitness Geeks Only

Play Episode Listen Later Aug 10, 2026 69:37


Emily Werner, PhD, RD, CSSD, IFNCP is Team Dietitian for the Philadelphia 76ers (NBA) and Philadelphia Flyers (NHL), and Nutrition Affairs Sport Lead at Timeline. Dr. Emily joins Dr. Mike to unpack postbiotics, urolithin A, and why mitochondrial health matters for pro athletes and everyday people alike, digging into the real research behind Timeline's Mitopure and why chasing $200K gadgets rarely beats getting the fundamentals right. Expect to learn what a postbiotic actually is and how urolithin A differs from other supplements, why old-school and new-school sports dietitians disagree on peptides and supplement fads, how chronic undereating quietly undermines performance in women's sports, what the current human performance research on urolithin A actually shows, how Mitopure is dosed and why urolithin A can't be reliably food-sourced, and why product quality and manufacturing integrity matter more than marketing claims, and much more. Connect with Emily: Website: https://www.eateliteperform.com/ Instagram: @emilywerner34 LinkedIn: https://www.linkedin.com/in/emily-n-werner-phd-rd-cssd-ifncp-4a820a97/ Episodes you'll enjoy next: #377 — Methylene Blue for Mitochondria & Performance: Benefits, Dosing & Risks with Dr. Scott Sherr: Listen here #382 — Creatine for Muscle, Bone, Brain & Longevity (Plus Caffeine, Dosing, and Safety) with Dr. Darren Candow: Listen here Episode Timestamps: 2:21 Welcome & introductions 6:09 What is a postbiotic? Pre-, pro-, and postbiotics explained 7:09 Urolithin A: the postbiotic behind Mitopure 8:19 How Emily started consulting for Timeline 10:11 Old-school vs. new-school sports dietitians on supplements 13:53 Peptides, anecdata, and why athletes ignore the data 20:05 The hardest lesson: letting go when clients won't listen 21:15 Money, ego, and athletes chasing $200K wellness gadgets 24:53 Chronic undereating in women's sports 30:48 Nutrition's real job: keeping athletes available to play 33:19 Inside Mitopure: Timeline's flagship urolithin A product 35:06 Mitochondria, mitophagy, and why they matter as we age 38:16 Diet, fasting, and exercise as natural mitophagy triggers 43:36 What the performance research on urolithin A actually shows 53:19 Aging, aerobic capacity, and Emily's 101-year-old grandma 55:40 Mitopure dosing: how much urolithin A and when to take it 57:14 Why urolithin A can't be food-sourced (and can't be faked) 1:03:19 Why product quality and integrity matter in supplements Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter

Regenerate You by Dr. Nirvana
Repair Your Mitchondria Naturally

Regenerate You by Dr. Nirvana

Play Episode Listen Later Aug 10, 2026 8:45


Feeling tired, gaining weight more easily, or noticing your hormones just don't feel the same? Your mitochondria, the tiny energy producers inside your cells, may be part of the missing piece. In this episode, I break down how mitochondrial health connects to energy, metabolism, and hormone balance, plus three key nutrients that can help support mitochondrial function naturally. If you feel like your body isn't working the way it used to, you'll want to hear this one.You can also watch the full video

Integrative Cancer Solutions with Dr. Karlfeldt
Chris Burres | C60 and Cancer: The Nobel Prize Molecule Your Doctor Never Mentioned

Integrative Cancer Solutions with Dr. Karlfeldt

Play Episode Listen Later Jul 29, 2026 43:15


What if the same molecule that earned three scientists a Nobel Prize could also protect your healthy cells while cancer treatment targets the sick ones?In this episode of Integrative Cancer Solutions, Dr. K sits down with Chris Burres, carbon nanomaterial engineer and co-founder of MyVitalC, to unpack the science behind ESS60, a purified form of the Nobel Prize winning C60 molecule. Chris walks through the peer reviewed research showing ESS60 extended lifespan in animal studies by 90 percent with zero tumor growth, and explains the Boss Theory, the idea that this molecule buffers oxidative stress inside the mitochondria, the same stress that drives inflammation, fatigue and cellular breakdown.The conversation covers what a selective antioxidant does differently during chemotherapy, why HSCRP, a key inflammation marker, matters for cancer patients, and the four clinical trials now underway, including one focused specifically on inflammation. If you are looking for research backed ways to support your mitochondria and lower oxidative stress during treatment or recovery, this episode lays out the science in plain language.Key Takeaways:0:00 Introduction2:06 How a Nobel Prize winning molecule became a daily supplement8:07 Wistar rats lived 90% longer with zero tumors9:52 ESS60 increases cancer cell death while protecting healthy cells19:44 The Boss Theory: how ESS60 buffers oxidative stress in the mitochondria28:43 Four clinical trials underway, from headaches to HSCRP32:45 Safety, drug interactions and real world dosage35:53 One drop, 400 times more molecules than cells in your bodySchedule a Free 15-Min Cancer/Lyme Consultation at The Karlfeldt Center: 208-338-8902Resources:MyVitalC (Dr. K's audience link, biohacking guide + discount) - https://www.myvitalc.com/drkLive Longer and Better by Chris Burres - https://a.co/d/05Vn4h3HOperation Underground Railroad - https://www.ourrescue.org Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions.

Intelligent Medicine
Intelligent Medicine Radio for July 25, Part 2: American Heart Association Does a 180° on Coffee

Intelligent Medicine

Play Episode Listen Later Jul 27, 2026 35:28


Aging-US
Preserving Peroxisomes Helps Maintain Mitochondrial Health and Extend Lifespan in C. elegans

Aging-US

Play Episode Listen Later Jul 21, 2026 5:22


BUFFALO, NY — July 21, 2026 — A new #research paper was #published in Volume 18 of Aging on July 6, 2026, titled “Inhibition of peroxisomal protein PRX-11 promotes longevity in Caenorhabditis elegans via enhancements to mitochondria.” The study was authored by Yash Flora, Dhriti Shastri, Kathryn R. DeLeo, and K. Adam Bohnert from the Department of Biological Sciences, Louisiana State University. Aging is accompanied by the gradual decline of many cellular structures that help maintain healthy tissues and organs. Among these are peroxisomes, which play essential roles in breaking down toxic molecules and metabolizing lipids, and mitochondria, which generate most of the cell's energy. Although these organelles work closely together, little has been known about how changes in one influence the aging of the other. This new study reveals that preserving peroxisomes helps maintain healthier mitochondria and extends lifespan in the nematode Caenorhabditis elegans, providing new insight into how communication between cellular organelles influences aging. In this study, the researchers investigated the function of PRX-11, a peroxisomal protein involved in peroxisome division. Previous work from the group showed that reducing PRX-11 activity prevents the age-related degradation of peroxisomes through a process known as pexophagy and increases lifespan. The new study explored why preserving peroxisomes produces these beneficial effects and found that maintaining peroxisomes also preserves mitochondrial health during aging. The researchers found that animals with reduced PRX-11 activity retained long, interconnected mitochondrial networks that resembled those seen in young adults, whereas normal aging was associated with progressive mitochondrial fragmentation. These preserved mitochondria also accumulated less calcium, generated lower levels of oxidative stress, maintained higher ATP-to-ADP ratios, and were associated with improved locomotor function in older animals. Together, these findings indicate that preventing age-related peroxisome loss supports multiple aspects of mitochondrial function during aging. Full press release - https://www.aging-us.com/news-room/preserving-peroxisomes-helps-maintain-mitochondrial-health-and-extend-lifespan-in-c-elegans DOI - https://doi.org/10.18632/aging.206395 Corresponding author - K. Adam Bohnert - bohnerta@lsu.edu Abstract video - https://www.youtube.com/watch?v=fbcqBsP90CY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206395 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular aging, lifespan, pexophagy, mitochondrial tubulation, inter-organelle crosstalk To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Men Talking Mindfulness
The Ultimate Superfood NASA Endorsed and You've Probably Never Heard Of: Dr. Catharine Arnston on Algae, Energy & Longevity

Men Talking Mindfulness

Play Episode Listen Later Jul 20, 2026 63:21


What if everything you've been taking to boost your energy, sharpen your focus, and fuel your body was covered by one single food?Dr. Catharine Arnston discovered algae sixteen years ago while researching how to help her sister heal from breast cancer, and it changed the entire direction of her life. NASA has endorsed algae as a complete food for space travel. The United Nations has called it one of the greatest solutions to human nutrition on Earth. Now 72, with a PhD earned last year and zero medications or chronic disease, Catharine joins Jon and Will to break down exactly how spirulina and chlorella work in the body,  from mitochondrial energy and testosterone to heavy metal detox and why men, specifically, are prone to a problem most have never heard of: cellular rust.As an algae nutrition expert, Catharine walks through the spirulina and chlorella benefits that define these algae superfoods, starting with mitochondrial health and its role in fueling cellular energy in men's nutrition. She explains how antioxidants for men neutralize free radicals, easing inflammation and testosterone disruption, while nitric oxide and blood flow support men's hormone health and performance. For men over 40, whole food supplements like ENERGYbits deliver longevity nutrition through high fiber content that strengthens gut health, complementing a Keto lifestyle. Catharine also details how algae supports heavy metal detox, binding toxic metals for gentle clearance, and positions itself as a natural energy supplement built on decades of research into cellular vitality and aging well.IN THIS EPISODE YOU'LL LEARN:1.  Why mitochondria are the real power plant behind energy, testosterone, and brain fog2.  Spirulina vs. chlorella: nourishment in, toxins out, and why men need both3.  The connection between nitric oxide, blood flow, and male performance4.  Why men accumulate stored iron — and how that quietly damages the heart and brain over time5.  Why most supplements fail to get absorbed, and what makes whole-food nutrition differentMore about Dr. Catharine Arnston:1.  Website: https://www.energybits.com2.  Discount Code: MTM for 20% off sitewide, no expiration3.  Instagram (brand): https://www.instagram.com/energybits4.  Instagram (personal): https://www.instagram.com/catharinearnston5.  LinkedIn: https://www.linkedin.com/in/catharinearnston6.  YouTube: https://www.youtube.com/energybits GET MORE FROM MTM:Text MTM to 33777 — free weekly newsletterSubscribe & Episodes: https://mentalkingmindfulness.com/FREE APP: https://focusnowtrainingapp.com/FREE Assessment: https://focusnowtraining.com/assessment-pageA2A COURSE:12 modules on attention, presence & performance. Self-paced. Built for people who hate the word mindfulness.https://focusnowtraining.com/a2a-courseBRING FNT TO YOUR TEAM:Custom training for your organization. In-person or online.https://focusnowtraining.com/contact-usProduced by Robert Lopez | https://www.cratesaudio.com/

Intelligent Medicine
Intelligent Medicine Radio for July 18, Part 2: Testosterone Screening for Troops

Intelligent Medicine

Play Episode Listen Later Jul 20, 2026 35:26


Pentagon plans widespread testosterone screening for troops; New study claims arthroscopic surgery for age-related degenerative changes of knees is worthless; Widely touted “precision” proton therapy doesn't outperform conventional radiation treatment for prostate cancer; Comparing the effectiveness of gummies and liquids vs. tablet or capsule forms of supplements; Supplements to lower LDL; Lithium orotate for Alzheimer's prevention; Novel ultrasound treatment may target inflammation in osteoarthritis; Researchers explore antiviral treatments for multiple sclerosis.  

Trensparent with Nyle Nayga
Dom Kuza: Anabolics, Reta, Peptides & Zombie Cells

Trensparent with Nyle Nayga

Play Episode Listen Later Jul 20, 2026 120:04


APR Health Solutions Peptides: www.aprhealthsolutions.com - code nyleOptimize HRT Clinic: https://members.optimize-hp.com - code nyleMerch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'nyle' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘nyle' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle (code nyle)00:00:00 Intro00:01:28 Detroit Life00:03:41 Context is King00:08:14 The Peptide Healing Journey00:14:13 Bodybuilding Stress & Sleep00:22:51 Retatrutide for Prep00:31:12 SLU-PP-332 & Endurance00:34:28 Mitochondrial Health & SS-3100:37:30 Clearing Zombie Cells00:41:19 Peptide Bio-Regulators00:47:47 Growth Hormone Truths00:52:36 Fixing Gut Health00:59:16 Mandatory Bloodwork Protocols01:06:06 Long Exposure Anabolics01:13:05 The Health Phase01:15:18 Estrogen & Aromatase Control01:18:57 Mini-Cuts & Insulin Sensitivity01:20:03 Training Volume vs Intensity01:28:28 Retatrutide Digestion Issues01:30:10 Sleep Apnea & High Hematocrit01:32:13 Pre-Workout Orals (Anavar)01:34:41 Fatherhood01:35:54 The StairMaster is Overrated01:39:09 Peri-Workout Insulin01:40:16 Why Supplements Fail01:42:17 Potassium Pulsing & Diuretics01:46:56 Clinical Medicine in Coaching01:47:51 DHEA & Skincare01:50:48 Complex Gut Health Case01:54:00 Adding Lantus to Prep01:57:40 5-Amino-1MQ Fat Loss02:00:00 Impact Over Hype

Intelligent Medicine
Leyla Weighs In: The Hidden Impact of B12 Deficiency on Aging

Intelligent Medicine

Play Episode Listen Later Jul 17, 2026 22:04


Vitamin B12 Deficiency--The “Aging” Symptoms You Shouldn't Ignore: Leyla Muedin, a registered dietitian nutritionist in New York City, discusses vitamin B12 deficiency as a common problem that can mimic normal aging, noting adults need only about two micrograms daily to support red blood cells, nerves, and DNA. She reviews the history of liver treatment for pernicious anemia and explains that deficiency remains common in older adults, vegans/vegetarians, and people with impaired absorption due to low stomach acid, autoimmune gastritis, weight loss surgery, or medications such as metformin and proton pump inhibitors. Symptoms can develop slowly and include fatigue, weakness, shortness of breath, numbness/tingling, poor balance, memory issues, and brain fog; she advises medical evaluation and B12 testing rather than assuming aging or relying on wellness-clinic injections when levels are normal. She emphasizes B12 is primarily in animal foods, so vegans need supplements, and notes broader nutrient shortfalls she sees in vegan clients.

The Sunday Session with Francesca Rudkin
Erin O'Hara: Naturopath and wellness expert on the benefits of improving mitochondrial health

The Sunday Session with Francesca Rudkin

Play Episode Listen Later Jul 12, 2026 6:21 Transcription Available


Mitochondria are the powerhouses of your cells, and they generate the ATP needed for survival. Declining mitochondrial performance is strongly associated with aging and age-related diseases. Naturopath and wellness expert Erin O'Hara reveals how to improve your mitochondrial health, including diet and stress management tips. LISTEN ABOVESee omnystudio.com/listener for privacy information.

Health Optimisation Podcast
"We've Been Aging Wrong" - Liz Earle On Hormones, Mitochondria & Midlife

Health Optimisation Podcast

Play Episode Listen Later Jul 8, 2026 66:54


Liz Earle, one of the UK's most respected voices in wellness, joins Tim Gray to explore why mitochondria are the master key to how we age, why body identical hormones change everything for women in midlife, and why the three things your cells need most are things no one can sell you.

Born to Heal Podcast with Dr. Katie Deming
What Water Fasting Does for Cancer That GLP-1s Don't | Semaglutide, Tirzepatide & Retatrutide | EP 147

Born to Heal Podcast with Dr. Katie Deming

Play Episode Listen Later Jul 7, 2026 25:30 Transcription Available


Before EP Description: Learn about the Healing Power of Prolonged Fasting: HEREWhat if losing weight on a GLP-1 drug and losing weight through fasting produce the same number on the scale, but nearly opposite effects inside your cells?Host Dr. Katie Deming believes some of the most popular weight loss drugs on the market may be quietly blocking one of your body's most essential repair processes. Not because they're failing to work, but because they work in a way that keeps your body in a state it was never meant to stay in.She takes an honest, no-shame look at GLP-1 drugs like Ozempic and Wegovy and compares what's actually happening inside your body when you lose weight on them versus when you fast. The scale might show the same number. The story underneath is very different. Dr. Katie explains a repair switch your body can only flip when your stomach is genuinely empty, and why keeping it perpetually fed may keep that switch turned off for good. She connects the dots between mitochondrial health, cellular cleanup, visceral fat, muscle preservation, and metabolic flexibility in a way that's clear, honest, and direct.She's not here to shame anyone taking these medications. She gets why people reach for something that works. But she shares what happened when several of her patients who were certain they'd go right back on the drug after fasting decided they didn't want to, and why.Chapters:00:04:23 - The Food System Is Broken00:06:13 - Your Body Needs Empty Space00:08:24 - GLP-1s May Block Repair Mode00:10:41 - Weight Loss Is Not Healing00:12:26 - What Cancer Cells Feed On00:13:30 - Fasting Changes the Terrain00:17:00 - Cleaning Out Damaged Mitochondria00:18:00 - The Most Dangerous Fat00:20:35 - The Hidden Muscle Loss Problem00:22:20 - Clients Who Were on GLP-1s Before Fasting00:26:06 - Who Should Never Water Fast If you've ever wondered whether weight loss and true healing are actually the same thing, or why one of her patients gained lean mass six weeks after a 14-day water fast, this episode will change how you think about what your body actually needs.Press play and learn why the repair process your body is waiting to run may only start when you finally stop feeding it.Join Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up Follow Dr. Katie Deming on InstagramWatch on YoutubeDISCLAIMER: The Born to Heal Podcast  is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.A thought-provoking podcast explores cancer through the lens of holistic medicine and functional medicine, discussing causes of cancer, metabolic health, and unconventional approaches like water fasting, fasting and autophagy, and detox, while weighing fasting benefits against chemo side effects and radiation side effects, sharing stories of a cancer survivor navigating chemotherapy, natural medicine, holistic healing, and even spiritual healing on the path toward cancer remission and holistic health. 

The Real Truth About Health Free 17 Day Live Online Conference Podcast
Fat, Iron, and the Hidden Dangers in Animal Products

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Play Episode Listen Later Jul 5, 2026 9:57


He explains how heme iron, saturated fat, and branched-chain amino acids in meat contribute to heart disease, diabetes, and aging. #HemeIron #AnimalFat #MetabolicHealth #Longevity

Intelligent Medicine
Urolithin A: A Pathway to Enhanced Energy and Longevity, Part 1

Intelligent Medicine

Play Episode Listen Later Jun 30, 2026 26:51


Urolithin A (Mitopure) and Mitochondrial Renewal--Muscle, Immune, and Skin Benefits: Jen Scheinman, MS, RDN, CDN, Director of Science Communications at Timeline details urolithin A and Timeline's branded supplement Mitopure. She describes urolithin A's discovery through pomegranate research and worm studies showing a 45% lifespan increase. She discusses human research including improved walking distance and clinical outcomes in muscle endurance and strength. Urolithin A is presented as supporting mitochondrial health by promoting mitophagy—recycling damaged mitochondria—distinct from other mitochondrial supports like CoQ10 and NAD precursors. They explain most people cannot produce enough urolithin A from foods because only 30–40% convert precursors via the microbiome and it would require about six cups of pomegranate juice daily. Dosing discussed is 500–1,000 mg/day via gummies, capsules, or powder, with effects developing over months. She reviews emerging research on immune aging, preclinical work on brain and neurodegenerative conditions, and topical urolithin A for skin.

The Lisa Fischer Said Podcast
Are Seed Oils Making Us Sick? With Cherie Calbom, The Juice Lady

The Lisa Fischer Said Podcast

Play Episode Listen Later Jun 23, 2026 47:57


Quantum Biology for Women over 40 begins with the choices we make at the grocery store—and the oils hiding in our favorite foods may be doing more harm than good.     In this eye-opening episode, Lisa Fischer sits down with nutrition pioneer Cherie Calbom, better known as The Juice Lady, to explore how juicing became her life's work and why she believes seed oils are fueling today's epidemic of inflammation and chronic disease. Cherie shares practical strategies for incorporating vegetable juicing without blood sugar spikes, explains the benefits of anti-inflammatory ingredients like turmeric and ginger, and offers simple ways to support Circadian Rhythm and Hormone Balance through everyday nutrition.     Together, they unpack the surprising history of seed oils, discuss the science behind oxidative stress, and reveal why more consumers are rethinking what's on their plates. From healthier cooking fats to navigating restaurant menus, this conversation equips listeners with realistic steps toward Non-Toxic Living and Hormone Recovery while supporting Mitochondrial Health and Cellular Aging.    

The Real Truth About Health Free 17 Day Live Online Conference Podcast
Toxic seafood, keto dangers, and anti-cancer lifestyle

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Play Episode Listen Later Jun 20, 2026 7:11


Contaminated fish and keto diets increase cancer risk. Dr. Fuhrman outlines the lifestyle steps that activate longevity genes. #SeafoodToxins #KetoRisks #LongevityPathways #HealthTalks

PricePlow
#221: Ben Hartman on Morphogen's Comeback, Nick Walker's Equity, and the 10g Tyrosine Return

PricePlow

Play Episode Listen Later Jun 11, 2026 102:49


Ben Hartman is back for his third visit to the PricePlow Podcast in Episode #221, and Morphogen Nutrition has never been in a stronger position. Ben walks through everything: the second rebrand’s full backstory, a never-before-told story about a failed acquisition that nearly sold the company, the financial reckoning that followed, and how selling the building and moving to a 3PL model finally cleared the slate. He calls this the best formula work Morphogen has ever done, at the healthiest margins in company history. The conversation covers AlphaGEN’s return to 10g L-Tyrosine, why PRIME is the anchor of the entire health line, details like how he navigates AstraGin® and BioPerine® across a multi-product stack, and the surprising origin of CALM. Then comes the main event: the Nick Walker equity partnership, explained in full, including some of the financial structure the internet has been speculating about. The episode closes with a frank look at the longevity wave ahead, the natural-vs.-enhanced debate, and a nostalgic look back at the golden age of stimulants. Subscribe to the PricePlow Podcast on your favorite platform and sign up for Morphogen Nutrition news alerts before diving in. https://blog.priceplow.com/podcast/ben-hartman-morphogen-nutrition-221 Video: Morphogen’s Second Rebrand, Nick Walker Equity, and the 10g Tyrosine Return https://www.youtube.com/watch?v=1avyjD3spOk Detailed Show Notes: Ben Hartman on Morphogen’s Rebrand, the Nick Walker Deal, and Where Supplements Are Heading (0:00) – Introductions (0:45) – The Second Rebrand: What Triggered It (3:00) – The Failed Acquisition: First Public Account (5:00) – David DeMesquita: The Missing Third Partner (8:45) – Business Lessons: Termites at the Foundation (12:30) – Best Formulas Ever, Healthiest Margins Ever (13:15) – Hero vs. Backup Ingredients: Supply Chain and Formula Thinking (18:30) – Diminishing Returns: “Racing to the Bottom” (20:30) – Breaking the Debt Cycle: PO Discipline and the Move to 3PL (27:45) – ALPHAGEN Reborn: The 10g L-Tyrosine Decision (30:15) – Eria Jarensis, Manufacturing Partners, and Label Honesty (35:15) – PRIME: Origin Story and the Anchor Health Product (40:30) – AstraGin® and BioPerine®: Choosing Absorption Enhancers Wisely (46:30) – CALM: From Bodybuilding Contest Prep to Gen Pop (51:15) – “I Don’t Listen to My Customers” (54:45) – Blood Work, Hormones, and Realistic Self-Assessment (1:01:30) – The Nick Walker Partnership: How It Actually Happened (1:04:30) – Equity, Not a Paycheck: “We Gave It to Him” (1:11:30) – Nick’s Feedback, Carb Fuel, and PROTEGEN on the Way (1:16:45) – From Bodybuilding Brand to Health and Wellness (1:21:30) – The Longevity Wave: NMN, Urolithin A, and Mitochondrial Health (1:27:00) – Natural vs. Enhanced: An Honest Reassessment (1:35:00) – The Supplements That Actually Moved the Needle (1:38:00) – Stimulant Nostalgia: DMAA, Ephedrine, and What’s Still Available (1:40:45) – Dedra Hartman (CFO) and Closing Thoughts Where to Follow and Learn … Read more on the PricePlow Blog

Intelligent Medicine
Revitalizing Energy with Membrane Lipid Replacement, Part 1

Intelligent Medicine

Play Episode Listen Later Jun 9, 2026 27:18


Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics, explains how membrane damage from free radicals and loss of mitochondrial transmembrane potential contribute to declining energy with age, noting studies in older adults showing improved energy output, fatigue, cognition, mood, and activity after NTFactor lipids, a protected phospholipid supplement balanced toward mitochondrial lipid composition. He describes evidence of lipid delivery using fluorescent-tagged lipids in sperm, with improved motility, and discusses applications including wound healing in veterans, removal of hydrophobic toxins via a concentration-driven “conveyor belt” process, and improved transport of nutrients like CoQ10. He details articles on normal aging, menopause-related changes supported by membranes, dementia risk linked to hearing loss, and rat studies showing delayed hearing loss with NTFactor, and mentions research on EMF sensitivity and planned schizophrenia trials.

Intelligent Medicine
Intelligent Medicine Radio for June 6, Part 2: The “5 Second Rule” for Dropped Food

Intelligent Medicine

Play Episode Listen Later Jun 8, 2026 44:31


Finding Genius Podcast
The Science Of Longevity: Mitochondrial Health, NAD+, & Aging Well

Finding Genius Podcast

Play Episode Listen Later Jun 5, 2026 33:43


In an era where longevity and anti-aging advice are everywhere, it can be difficult to separate meaningful science from marketing hype. What actually works when it comes to living longer, feeling better, and maintaining peak performance as we age? In this episode, Michael Linares joins the podcast to share his insights… Michael is the CEO of Longevity Farms, a wellness company dedicated to helping people optimize performance, recovery, and long-term health. Through evidence-based supplementation, education, and a focus on cellular wellness, Michael and his team aim to help individuals improve their energy, resilience, and overall quality of life as they age. Hit play to learn more about: The "holy grail" of longevity optimization. Why mitochondrial health plays a critical role in healthy aging. The connection between cellular energy production and overall wellness. How to boost NAD, and why it matters.  Michael's passion for longevity was shaped by more than 15 years of experience as a personal trainer and nurse educator, where he developed an interest in human physiology and the science of aging. Inspired by conversations with his brother Joe Linares, a firefighter-paramedic and fitness enthusiast, he began exploring emerging research on longevity and the biological processes that influence how we age. Connect with Michael:  Instagram Longevity Farms Website

The Sleep Is A Skill Podcast
266: Meredith Oke, Host of the Quantum Biology Collective & Non-Profit Founder: How Your Light Environment Might Be Destroying Your Sleep Quality

The Sleep Is A Skill Podcast

Play Episode Listen Later Jun 3, 2026 48:01


Meredith Oke is the host of the Quantum Biology Collective podcast and non-profit founder, Meredith has been down the sleep rabbit hole for years, learning what works, what doesn't and how to raise a family that sleeps.   SHOWNOTES:

Live Well Be Well
How To Stop Overthinking Things You Can't Control With Dr Hannah Critchlow

Live Well Be Well

Play Episode Listen Later Jun 3, 2026 106:03


Have you ever wondered why your brain feels like it's working against you when actually, it might just be waiting for you to understand it?This week I'm joined by Dr. Hannah Critchlow, neuroscientist, Cambridge University researcher, and author of 21st Century Brain, and this conversation genuinely shifted something for me.Hannah has a way of taking the science of your brain and making it feel like something you can actually use, today. Not in a "10 steps to fix yourself" way.What we explore together:Why does your brain fear uncertainty more than pain itself, and what does that mean for how you handle stress and change?Did you know emotional intelligence is a bigger predictor of life satisfaction than IQ, and that it can actually be trained?How is your gut shaping your mood, your empathy, and even how kind you are to complete strangers?What are sleep, nutrition, and movement really doing for your brain, and why do amino acids matter so much at night?Why is walking in nature one of the most underrated tools for emotional regulation?What does the rise of AI relationships mean for real human connection, and what are we at risk of losing?Why is curiosity our greatest superpower, and how do we protect it?Love, Sarah Ann

Intelligent Medicine
Intelligent Medicine Radio for May 23, Part 1: Persistent Itch

Intelligent Medicine

Play Episode Listen Later May 25, 2026 43:06


Intelligent Medicine
Intelligent Medicine Radio for May 23, Part 2: Menopausal Sleep Problems

Intelligent Medicine

Play Episode Listen Later May 25, 2026 44:13


You won't believe this new medical use for Classic Coca-Cola; The solution for menopausal sleep problems goes beyond mere hormone replacement; Paxlovid strikes out vs. Covid in new trials; Pesticide exposure may explain rising colorectal cancer rates in young people; Big Food touts faulty study that claims healthier food regulations will cost consumers; Higher aerobic fitness boosts size of the brain's memory centers—as does memorizing London taxi routes. 

The Real Truth About Health Free 17 Day Live Online Conference Podcast
Flavonoids Support Antioxidant Enzymes in the Brain

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Play Episode Listen Later May 24, 2026 12:35


Flavonoids Support Antioxidant Enzymes in the Brain; Berry Compounds Cross Blood-Brain Barrier; Anthocyanin-Rich Berries Rescue Dopamine Cells; Peppers and Nicotine Receptors in Parkinson's; Ashwagandha for Gait and Brain Protection; Licorice Root Reduces Tremors and Sweetens Tea; Ginkgo Biloba Restores Dopamine and Protects Brain; Lowering Homocysteine with B12 and Folate #Parkinsons #BrainHealth #NeuroNutrition #HealthTalks

Solving the Puzzle with Dr. Datis Kharrazian
Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health

Solving the Puzzle with Dr. Datis Kharrazian

Play Episode Listen Later May 20, 2026 28:13


In today's episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue.We'll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You'll discover why bagfuls of supplements aren't enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins.Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromesTo become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 Factors affecting mitochondrial function03:55 Optimizing patient bioenergetics basics09:27 Mitochondria and cell evolution12:33 Focus on acquired mitochondrial dysfunctions14:23 Mitochondrial ATP production process20:22 Ketogenic diet and energy pathways21:15 Ketogenic diet for chronic fatigue27:02 Exploring functional medicine resourcesSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

The Ultimate Human with Gary Brecka
265. Tyler LeBaron: Hydrogen Water, Mitochondrial Health, Selective Antioxidants, & Longevity

The Ultimate Human with Gary Brecka

Play Episode Listen Later May 11, 2026 112:26


Could the smallest molecule in the universe be one of the most powerful tools for your health? I brought Dr. Tyler LeBaron, the world's leading molecular hydrogen researcher, onto the Ultimate Human Podcast to break down what hydrogen water actually does inside your body, why it's nothing like alkaline water, and what the clinical research really says about recovery, cognitive function, metabolic health, and more.  CLICK HERE TO BECOME GARY'S VIP!: https://bit.ly/4ai0Xwg Access Tyler LeBaron's research studies here: https://bit.ly/3Q8mth8  Read the “New Breakthrough Study Identifies First Molecular Target of Hydrogen in Human Cells” study here: https://bit.ly/3QBGPzo  InhaleH₂ delivers precision hydrogen inhalation therapy. Get $250 OFF: https://bit.ly/4uDQfcm Listen to "The MHI Podcast" here: https://bit.ly/4cHxM8G  Connect with Tyler LeBaron Website: https://bit.ly/4vAXGTh  YouTube: https://bit.ly/48v7a8u  Instagram: https://bit.ly/4ekV7hK  Facebook: https://bit.ly/47W7qxg   X: https://bit.ly/4tcQH1b  LinkedIn: https://bit.ly/4cmXAG1  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij  AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD  AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze  BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa  BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV  COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp  CYMBIOTIKA: "ULTIMATE10" FOR 10% OFF: https://bit.ly/4tjyluP  GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk  GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9  GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC  H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg  HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S  PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn  SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V  WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW  Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 ​Intro of Show 06:33 Research on Hydrogen 12:30 Different Hydrogen Forms 16:26 Affiliation with Research Institutions 27:33 Hydrogen as a Selective Antioxidant 32:41 Redox Homeostasis Definition 40:46 Hydrogen Regulating Natural Antioxidants 55:31 Hydrogen for Athletic Performance 1:10:24 Hydrogen's Impact on Women's Hormones  1:12:40 Metabolic Syndrome and Hydrogen 1:20:24 Healthy Microbiome Producing Hydrogen Gas 1:23:41 How to Start with Hydrogen Tablets? 1:27:02 Other Benefits of Hydrogen  1:38:46 Hydrogen in Post-Cardiac Arrest Syndrome Patients' Survival 1:48:59 Connect with Tyler  1:43:23 Safety of Taking Hydrogen Tablets 1:49:53 What does it mean to you to be an Ultimate Human? Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Biohacking Superhuman Performance
#436: Is Your Body's Terrain Hospitable For Cancer? Affordable Lab Tests, Metabolic Flexibility, and Emotional Foundations With Dr. Nasha Winters

Biohacking Superhuman Performance

Play Episode Listen Later May 8, 2026 114:57


Today, I'm thrilled to welcome Dr. Nasha Winters back to the show for part two of our powerful conversation. As a trailblazer in integrative oncology and a passionate advocate for the “metabolic terrain” approach to health, Dr. Winters brings both deep expertise and a truly holistic perspective to the complex world of cancer and longevity. In this episode, she doesn't just share concepts—she takes us into the heart of what it means to test, assess, and address our own health in real life, especially when we're facing major diagnoses and difficult decisions. Episode Timestamps: Welcome & Introduction to Longevity Podcast ... 00:00:00 Metabolic Terrain Concept & Mitochondrial Health ... 00:05:00 The Test, Assess, Address Framework ... 00:08:08 Readiness, Honest Audit, and Lifestyle Evaluation ... 00:08:43 The Ten Terrain Drops in Cancer & Health ... 00:14:09 Emotional Foundations for Healing ... 00:15:01 Essential Lab Markers and the “Trifecta” ... 00:16:52 Affordable, Early Detection Labs—CBC, CRP, LDH, ESR ... 00:17:32 Shift Work, Circadian Health, and Mitigating Strategies ... 00:29:11 Handling Overwhelm: Prioritizing Fundamentals ... 00:37:45 Prevention Myths: Sun, Meat, and Food Access ... 00:42:26 Home-Cooked Food & Community's Healing Power ... 00:51:16 Behaviors That Seem Healthy But Aren't (e.g., Excess Cardio) ... 00:54:55 Age-Specific Advice and Building Longevity ... 00:56:25 Cancer, Metabolic Flexibility, and Biomarker “Under Five” Rule ... 01:02:32 Integrative Oncology's Strengths & Misconceptions ... 01:08:48 Risks of Extreme Alternative or Mainstream Approaches ... 01:12:58 Post-2020: Changing Health Trends & Immune Patterns ... 01:17:03 Hope for the Future & Patient Empowerment ... 01:24:02 Our Amazing Sponsors: STEMREGEN by Stemregen - A daily formula designed to support your body's natural repair systems by helping release your own stem cells into circulation, supporting recovery, resilience, and whole-body renewal at the source. Visit stemregen.co/NAT15 and use code NAT15. https://stemregen.co/NAT15 Vampire Exosome by Young Goose - A next-generation serum packed with three trillion PRP-derived exosomes and RejuvNAD to support collagen production and skin renewal at the cellular level—helping results build over time instead of fading fast. Shop HERE and use code NAT10. Bioregulators by Nature's Marvels - targeted peptides designed to support cellular signaling and renewal across key systems like circadian rhythm, immune function, and vascular health as part of a foundational longevity stack; head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

The Longevity Formula
How a Nobel Prize Molecule Could Add 20+ Years to Your Life | Chris Burres

The Longevity Formula

Play Episode Listen Later May 8, 2026 67:43 Transcription Available


In 1985, three scientists at Rice University discovered a carbon molecule so structurally perfect it eventually earned them the Nobel Prize in Chemistry. What nobody anticipated was what would happen when researchers gave it to rats — a 90% extension in lifespan, the longest longevity result ever recorded in mammalian history.Chris Burres has been manufacturing this molecule since 1991, five years before the Nobel Prize was awarded. He joins Dr. Brandon Crawford to break down how ESS60 (Carbon 60) works at the mitochondrial level, why it functions as a buffering oxidative stress system rather than a conventional antioxidant, and what the growing clinical evidence suggests about its effects on sleep, inflammation, cognition, and long-term healthspan.ResourcesMyVitalC Exclusive Offers: 40% discount on 6-bottle bundle, $30 coupon, and 18 free biohacking tips when you use the link myvitalc.com/crawfordLive Longer and Better by Chris Burres and Jerome Corsi (autographed copies available with proceeds supporting Operation Underground Railroad)Operation Underground Railroad — Non-profit combating child exploitation (100% of autograph fees donated)Live Beyond the Norms Podcast hosted by Chris BurresFollow MyVitalC on Instagram2012 Baati Study — Peer-reviewed research showing 90% lifespan extension in Wistar rats SES Research Inc. — Manufacturing and research company (since 1991, Houston, Texas)‍Products528 Innovations LasersNeuroSolution Full Spectrum CBDNeuroSolution Broad Spectrum CBDNeuroSolution StimpodSTEMREGEN®Learn MoreFor more information, resources, and podcast episodes, visit https://tinyurl.com/3ppwdfpm

Intelligent Medicine
Enhancing Muscle Quality: A Deep Dive into Mitochondrial Science, Part 1

Intelligent Medicine

Play Episode Listen Later May 5, 2026 31:06


Urolithin A (MitoPure)--Mitophagy, Muscle Recovery, Immunity, and Skin Health: Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company, details urolithin A (MitoPure), a postbiotic derived from pomegranate precursors that most people cannot produce due to microbiome differences. Currier explains MitoPure's mechanism—stimulating mitophagy to recycle dysfunctional mitochondria—and reviews evidence from multiple clinical trials. He reveals a Sports Medicine study in elite male distance runners showing reduced creatine kinase and lower perceived exertion, suggesting improved recovery, plus trials in middle-aged and older adults showing improvements in strength, six-minute walk test, and VO2 max at 500 mg–1 g doses. They also cover a Nature Aging immune study reporting rejuvenation of stem-like CD8 T cells with improved mitochondrial fatty acid oxidation, ongoing research directions, supplement quality/testing for athletes, and topical urolithin A skincare trials and partnerships, including L'Oréal Lancôme.

Think BIG Bodybuilding
It's Just Bodybuilding 384 Can Retatrutide Kill Your Motivation? Vigorous Steve Explains Dopamine

Think BIG Bodybuilding

Play Episode Listen Later Apr 29, 2026 105:17


Vigorous Steve joins It's Just Bodybuilding to break down the real effects of retatrutide on dopamine, motivation, and relationships. We dive into his experimental DHT-only cycle and how modern bodybuilders are approaching PEDs differently. Plus: cholesterol management, mitochondrial health, and the long-term cost of getting big. 0:00 Vigorous Steve Interview Begins 1:30 Welcome Vigorous Steve to the Podcast 2:30 Will Vigorous Steve Go on Joe Rogan? 4:00 Retatrutide & Dopamine Effects Explained 6:00 GLP-1 Drugs Compared (Ozempic vs Retatrutide) 10:00 How Retatrutide Works & Why It's So Popular 12:00 Does Retatrutide Lower Dopamine & Motivation? 14:40 Dopamine vs Love: Are Feelings Really Affected? 21:20 Why Doing Hard Things Builds Growth & Discipline 24:45 Who Should Use Retatrutide? 29:40 Using Retatrutide in the Offseason for Bodybuilding 33:20 Vigorous Steve's New DHT-Only Cycle Explained 37:00 How DHT Impacts Estrogen Levels 39:25 Can DHT Prevent or Reduce Gynecomastia? 43:00 Primobolan vs Masteron vs Equipoise (Key Differences) 45:45 Cholesterol in Bodybuilders: Causes & Fixes 49:45 Supplements for Cholesterol (Dante Trudel Protocol) 55:15 Why LDL Gets High on Steroids (Perfect Storm) 56:25 Are Steroid Carrier Oils Dangerous? 1:03:30 The PED Experiment Steve Regrets Most 1:05:45 Mitochondrial Health & Reducing Oxidative Stress 1:15:30 Starting PEDs Too Early: Long-Term Consequences 1:29:00 Bodybuilding Lifestyle in Thailand 1:42:45 Behind the Scenes

Intelligent Medicine
Intelligent Medicine Radio for April 25, Part 1: Does drinking carbonated water help weight loss?

Intelligent Medicine

Play Episode Listen Later Apr 27, 2026 43:09


New-think on diet for ApoE4, a risk factor for Alzheimer's—eat meat! Is a non-invasive blood sugar monitor on the drawing board for the next Apple Watch? True or false—does drinking carbonated water help weight loss? Eating while distracted puts on the pounds; Treating duodenitis; How much whey protein should you consume? Why some people fail to lose weight on GLP-1 drugs.

Intelligent Medicine
Intelligent Medicine Radio for April 18, Part 1: HIIT to Optimize Disease-Prevention

Intelligent Medicine

Play Episode Listen Later Apr 20, 2026 43:17


Pump up the volume on your exercise with HIIT to optimize disease-prevention; Natural ways to lower your LDL; Choline's impact on the menopausal brain; How targeted supplementation can boost your nitric oxide for better health, an interview with Dr. Nathan Bryan, creator of N1O1.

Vitality Radio Podcast with Jared St. Clair
#630: Cutting-Edge Supplements for Zombie Cells and Longevity: Fisetin, Spermidine & Butyrate

Vitality Radio Podcast with Jared St. Clair

Play Episode Listen Later Apr 15, 2026 34:12


On this episode of Vitality Radio, Jared dives into three cutting-edge supplements gaining attention in the world of longevity and metabolic health: fisetin, spermidine, and butyrate. These compounds work in complementary ways—supporting the body's natural ability to clear aging cells, promote cellular renewal, and optimize gut-driven metabolic signaling. Jared breaks down how “zombie cells” (senescent cells) contribute to inflammation and aging, how autophagy supports cellular efficiency, and why gut health plays a central role in cravings, blood sugar balance, and GLP-1 activity. He also shares practical insights on dosing strategies, including pulse dosing, and how to determine if these advanced tools may fit into your current wellness routine. If you're looking to better understand the connection between cellular health, metabolism, and gut function, this episode offers a thoughtful, research-informed perspective.Products:Buy Fisetin AND Spermadine, get 20% off the sale price! (limited time)Buy 3 or more bottles of GLP-1 Metabolic Optimizer, get $10 off each bottle! (limited time)RegenerLife Sodium Butyrate Postbiotic PacketsJust Ingredients Probiotic Complex - capsulesViRadChem BinderMagnesium BisglycinateAdditional Information:#627: GLP-1 Explained Part 1: How to Support Metabolism Without Drugs#628: GLP-1 Explained Part 2: The Lifestyle Blueprint for Real Metabolic OptimizationVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

The Cabral Concept
3691: ADHD Medication & Impulsivity, Mitochondrial Health, Long-Term Toxin Exposure, Heavy Metal Detox & Itching, Nighttime Urination (HouseCall)

The Cabral Concept

Play Episode Listen Later Mar 15, 2026 17:14


Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…    Emily: My sibling was diagnosed with ADHD at a very young age and has been taking ADHD medication for at least 5 years. In the IHP level one course we were learning about neurotransmitters and you were speaking about how having to much adrenaline and dopamine can cause behavioral issue among many other issues. My sibling has had behavioral issues such as compulsive lying, very impulsive, and it seems that she does not think though any of her actions as if her actions have no consequences. Its beyond the normal rebellious teen. I was curious if this could possibly be due to the adhd medication that she has been taking? If so, can you please explain? What labs should we run? How would someone wean off adhd meds? Any other recommendations? Thank you!       Andy: I'd love to get your professional opinion on Mitopure (urolithin A). What does the current research say about its effectiveness for mitochondrial health and longevity, and do you see real-world benefits in your patients or practice?      Sarah: Hello! My husband and I own and operate a diesel truck repair shop and have been in business for 11 years. During that time, I've had regular exposure to diesel exhaust, fumes, solvents, and shop air. Over the past few years, I've experienced some ongoing health concerns (inflammation, fatigue, gut issues) and am wondering whether long-term exposure could be contributing. I'm interested in a functional medicine approach to evaluate possible toxic burden or inflammation and to understand what testing, lifestyle changes, or supplements might help support lung health, detox pathways, and overall wellness. I'm looking for a proactive, preventative approach while continuing to run our business. Any help would be greatly appreciated! Thank you!      Anonymous: I started listening to your podcasts a few years ago, and I've learned how to improve my health and quality of life in many ways—so thank you for sharing your knowledge! Question: My heavy metals test showed high levels of mercury and aluminum. Recently started processes to remove them: functional medicine detox (5 days) > intestinal cleanse (2 days) > heavy metal detox (30+ days, still going), and another intestinal cleanse (2 days on 30th day). Feeling mentally and physically better - like my "old self" again. When I started the HM detox, my bowel movements started having a strong smell and causing my anus to itch. Is that due to an elimination of heavy metals or due to ingredients in the detox or cleanse? Thanks.      Pete: Hi Stephen, Thanks for the great work you do. I wake up every night once (sometimes twice) to urinate and would love your thoughts on how to sleep through the night. Some background: I'm a 40-year-old male, generally healthy, eat clean, and don't drink alcohol. I stop eating about three hours before bed and limit fluids in the evening. No caffeine after noon. During the day I also urinate frequently, which I can manage. At night the volume is small, but the urgency signal is strong. I've been checked by a doctor (including prostate), everything looks normal, and I've tried a few medications with limited effect. I'd really appreciate your thoughts on any protocols or angles that might be worth exploring. Best, Peter    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3691 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

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The Human Upgrade with Dave Asprey
Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430

The Human Upgrade with Dave Asprey

Play Episode Listen Later Mar 12, 2026 63:19


Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors! Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization Resources: • Learn More About Dr. Houman's Work At: https://houmanmd.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Introduction 01:15 – Low Testosterone Epidemic 04:23 – Ejaculation & Testosterone 07:30 – Refractory Period & Aging 09:58 – Porn-Induced ED 11:09 – Cabergoline & Prolactin Management 12:42 – Oral Testosterone 13:24 – Testosterone Target Levels 16:46 – Supplements for Testosterone 18:46 – Anxiety-Based ED 26:23 – Penis Enhancement Options 27:37 – Shockwave Therapy 28:57 – Cialis for Longevity 29:56 – Fat & Filler Injections 34:50 – Pre-Sex Optimization 40:13 – Red Light Therapy 42:18 – Heat & Cold for Testosterone 43:35 – Underwear & Microplastics 44:58 – Testosterone & Fertility 49:15 – HCG & Preserving Fertility 52:00 – Testosterone Dosing Timing 53:22 – Creatine & Mitochondrial Health 55:20 – Overtraining Effects 56:24 – Peptides (PT-141) 59:08 – Optimal Diet for Fertility See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Human Upgrade with Dave Asprey
The Secret to Staying DANGEROUS After 50 : 1422

The Human Upgrade with Dave Asprey

Play Episode Listen Later Feb 26, 2026 60:34


Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You'll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. Then the conversation turns into what's new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. You'll Learn: • What peptides are, explained without jargon • Why delivery matters and why pens beat mixing vials all day • How PK curves change real results and dosing schedules • What elamipretide means for mitochondria and longevity • Why MOTS-c can feel like a fast energy shift for some people • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support • Why MK-677 sounds easy but can bring unwanted effects • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss • Why Klotho shows up in longevity research and why dose matters Thank you to our sponsors! • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection Resources: • Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:22 – Introduction to Peptides 7:52 – Peptide Delivery Systems & Pens 14:22 – Safety & Regulation of Peptides 19:22 – SS-31 & Mitochondrial Health 26:22 – Blending Peptides & Cross-Linking 38:22 – Growth Hormone Peptides 44:22 – FLGR-242: The New Myostatin Inhibitor 54:22 – Melanin & Consciousness 57:22 – Klotho: The Longevity Peptide 59:25 – Regulatory Landscape & Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.