Podcasts about pain support

As we advertised last month, Father Larry is starting a support group that will meet online via Zoom periodically. If you've already signed up, no further action is required. If you want to sign up, do so at the following link or email Bill@thedeeperdivepodcast.com: https://web4u.forms-db.com/view.php?id=1920399 --- Send in a voice message: https://podcasters.spotify.com/pod/show/william-wannall/message Support this podcast: https://podcasters.spotify.com/pod/show/william-wannall/support

Discussing a special oil blend originally developed for after surgery discomfort.Also mention of new book available in Amazon: Natural Essential Oil Remedies and Recipes, by Wendy Selvig

Pleasure in Pain --- Support this podcast: https://podcasters.spotify.com/pod/show/daisy726/support

Do the French really eat "pain" for breakfast? Here's the support guide for episode 6.

Are you struggling with chronic bladder infections, bladder and pelvic pain, and wondering what else you can do to find the relief you need? In today's episode we are going to talk about the root causes of bladder issues, how to test and address them, anatomy and structural issues, lifestyle, supplements, body support, and so many options that are available to you.

Rob and Otto kick off part 2 of Welcome to Skidmore!! Meet Skidmore Missouri's town asshole/bully Ken Rex McElroy. This man was such a giant pain in the ass to the entire town. So much that he ended up shot dead in broad daylight and not a single witness stepped forward. No one saw a thing. Music by House of Pain --- Support this podcast: https://anchor.fm/rob-west8/support

In this one our host Shannon covers Generalization for the jargon of the day before discussing the question of the day with the live viewers! After that, Shannon talks about the topic of the week while taking viewer questions! Then, Shannon is joined by Millie Quiñones-Dunlap, a New York State Certified Teacher/Librarian for twenty years and is also currently working on her memoir, “Through the Eyes of a Bronx Girl.” Check it out!

In this one our host Shannon covers Generalization for the jargon of the day before discussing the question of the day with the live viewers! After that, Shannon talks about the topic of the week while taking viewer questions! Then, Shannon is joined by Millie Quiñones-Dunlap, a New York State Certified Teacher/Librarian for twenty years and is also currently working on her memoir, “Through the Eyes of a Bronx Girl.” Check it out!

Pain Support beyond Mindfulness by Natural Wellness & The Empathic Herbalist

Push Past the Pain --- Support this podcast: https://anchor.fm/clevin-brailsford/support

Many people living with pain find peer support programs help them to feel heard and understood, and reduce their feelings of isolation and helplessness that often accompany pain.In this month's episode of the Pain Waves podcast, we discuss how our free Pain Support and Wellness Groups are providing people in pain with opportunities to meet regularly online and build a community of support while learning about pain management and sharing coping strategies. We're joined by a number of different guests - Dorota Hedzelek, Pain BC's Director of Support Services, as well as two volunteer facilitators, Dwayne and Juhree, and two group participants, Jenny and Mike - who offer their unique perspectives on the program and how it benefits people in pain.To learn more about accessing a Pain Support and Wellness Group, visit https://www.painbc.ca/supportgroups

This “king of bitters” (so-called because of its flavor) has been used for centuries in Asia to treat gut and upper respiratory infections, fever, herpes, sore throat, and other chronic and infectious disease conditions. However, modern research is demonstrating Andrographis paniculata’s benefits include aiding with joint conditions such as arthritis. ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More The medicinal herb Andrographis paniculata has been traditionally used for its powerful anti-inflammatory properties and its ability to boost immune system activity. This “king of bitters” (so-called because of its flavor) has been used for centuries in Asia to treat gut and upper respiratory infections, fever, herpes, sore throat, and other chronic and infectious disease conditions [1]. However, modern research is demonstrating Andrographis paniculata’s benefits include aiding with joint conditions such as arthritis and it may even have anti-cancer benefits. Andrographis Goes by Many Names Andrographis is cultivated in many tropical Asian countries including India, China, Malaysia, Indonesia, and Sri Lanka, as well as in the West Indies, Brazil, parts of Africa, and Central America. Known as “chuan-xin-lian” in China, “kalmegh” in India, “senshinren” in Japan, “hempedu bumi” in Malaysia, “fah talai” in Thailand, and “green chiretta” in the Scandinavian countries, Andrographis is listed in the Indian Pharmacopoeia (a publication that lists standards for all drugs that are manufactured, sold, and consumed in India) and in a couple of dozen Ayurvedic formulas [2]. In traditional Chinese medicine (TCM), Andrographis is believed to rid the body of heat (e.g., fevers) and to dispel toxins [3]. Phytochemistry of Andrographis Paniculata Andrographis leaves are mainly responsible for its biological actions. They contain many bioactive compounds, including diterpene lactones – especially Andrographolide, the main bioactive ingredient that imparts the typical bitter taste. Andrographolide is an antioxidant that has been shown to be responsible for the herb’s anti-viral and anti-bacterial properties. Andrographolide is also reported in scientific literature to reduce blood clot formation, help protect the liver, have anti-cancer properties, and manage inflammation within safe levels [4]. What Is ParActin®? ParActin® is a patented extract of A. Paniculata, standardized to a fixed concentration of Andrographolide and other related compounds including 14-deoxyandrographolides and neoandrographolides [5]. Preliminary research shows that ParActin® promotes a healthy inflammatory response by blocking a powerful chemical known as NF-kappa B, which is known to be a key regulator of the inflammatory response system. As a result, ParActin® helps support a healthy and appropriate inflammatory response by reducing the levels of pro-inflammatory compounds that trigger the familiar pain and redness associated with inflammation. The safety and efficacy of ParActin® has been assessed in more than 30 studies, including laboratory experiments on cultured cells and animal models – and even a human clinical trial. Let’s take a closer look at some of these studies and what they tell us about Andrographis and ParActin®. Inflammation Is Linked to Many Disease Conditions Long-term, chronic inflammation that occurs when the immune system goes into overdrive may lie at the root of many otherwise unrelated diseases, including: asthma inflammatory bowel disease (IBD) rheumatoid arthritis (RA) autoimmune diseases depression cancer Alzheimer’s disease Inflammation – which manifests as swelling, redness, heat, and pain – is a normal response of our immune system and our body’s way of defending us from infections and disease. However, if it’s not managed properly, inflammation can harm the body. Chronic inflammation is the result of an overactive immune system that is constantly turned on – or cannot be turned off – so that it attacks parts of the very body it is supposed to protect. So-called oxygenated chemical species – including free radicals, oxygen ions, and peroxides – are continuously made in our body’s cells in response to UV radiation and as byproducts of ongoing metabolic activity. They are highly reactive and dangerous, because they can attack cellular DNA and proteins, damaging them. When oxygenated chemical species are generated in excess, they can overwhelm cellular defense systems, leading to a condition known as oxidative stress along with high levels of inflammation – which, as we discussed earlier, is known to contribute to the development of many diseases. Andrographolide, the best-known bioactive ingredient in Andrographis, has been shown to directly inactivate free radicals. It also protects mitochondria, blocks pro-oxidant enzymes, and activates other antioxidant enzymes in the body [6]. Andrographis Boosts the Immune System Andrographolide has been shown to enhance the immune system. For example, it boosts production of white blood cells known as lymphocytes, which scavenge and destroy bacteria and other foreign matter. It also triggers the release of signaling proteins known as interferons, along with enhancing activity of the lymphatic system [7]. Interferons are made and released by our body’s cells when they get infected with viruses, causing nearby cells to strengthen their anti-viral defenses. Interferons are potent antiviral agents that stop viruses from multiplying. The lymphatic system is another circulatory system in our body that carries a fluid known as lymph, which removes the waste products of cellular metabolism. The lymphatic system also transports invading bacteria and viruses to lymph nodes where the white blood cells (lymphocytes) destroy them. Andrographis has been shown to trigger our immune system in two ways: Antigen-specific response – specific proteins known as antibodies are made to counteract invading bacteria and viruses. Nonspecific immune response – immune cells known as macrophages are produced, which scavenge and destroy invaders. Andrographis activates both responses, meaning it is very effective against a variety of infectious and cancer-causing agents [8]. Benefits for Upper Respiratory Tract Infections & Cough Andrographis has been used for many hundreds of years in traditional medicinal systems to treat upper respiratory infections. Modern research supports this. For example, a 2004 meta-analysis of the results of seven double-blind, controlled trials (with a total of 896 participants) showed that Andrographis offers significant relief from the symptoms of upper respiratory tract infections and may even prevent them from taking hold in the first place. [Note: A meta-analysis is a quantitative epidemiological study used to systematically assess the results of previous research – typically randomized, controlled clinical trials – to derive overall conclusions about that body of research.] All the participants in these seven clinical trials reported reduced fever, runny nose, cough, and sore throat on taking Andrographis relative to control patients. Side effects were described as “generally mild and infrequent” [9]. Similarly, another meta-analysis published in 2015 reviewed six randomized controlled clinical trials, which assessed the effects of Andrographis in the treatment of cough. Combined, these six studies compared 333 patients who took various Andrographis preparations relative to 348 patients in control groups. All of these studies showed that Andrographis preparations reduced cough severity [10]. Andrographis Heals the Gut As mentioned above, Andrographis has long been used in traditional medicinal systems such as Ayurveda and traditional Chinese medicine (TCM) for treating gut infections. In a 2013 study published in the American Journal of Gastroenterology, 224 patients with mild to moderate ulcerative colitis were either given 1200 or 1800 milligrams of Andrographis for 8 weeks. Ulcerative colitis is an inflammatory bowel disease that causes long-lasting inflammation and ulcers in the gut, affecting the innermost lining of the large intestine (colon) and rectum. A colonoscopy was performed before the study started and after it ended. Stool frequency and the presence of blood in the stool were also assessed every two weeks. At the end of the study, 60% of patients who received 1800 mg of Andrographis – relative to 40% of patients in the control group – showed clinical symptoms of healing. Not only that, 50% of the patients who received the 1800 mg of Andrographis also showed mucosal healing, relative to 33% in the control group [11]. Andrographis & Joint Pain from Arthritis Arthritis affects more than 70 million Americans, leading to inflammation, pain, and stiffness in the joints and connective tissues. Over time, cartilage breaks down, bones erode, and joints become misshapen [12]. Our modern understanding is that rheumatoid arthritis (RA) happens because of the uncontrolled inflammation that is typical of an autoimmune disease. In such situations, the body’s defense mechanism malfunctions and attacks its own tissues (e.g., healthy joints) for a prolonged period of time. An immune-signaling protein known as cachexin or tumor necrosis factor-alpha is one of the key drivers of inflammation. Andrographolide has been shown to lower levels of cachexin. ParActin® and Mild Knee Osteoarthritis In a randomized, double-blind, placebo-controlled study the efficacy of ParActin® (300 and 600 mg daily) was assessed on pain reduction in 103 patients with mild to moderate knee osteoarthritis [13]. Patients treated with ParActin® showed a significant reduction in pain relative to the control group. Stiffness, physical function, and fatigue all showed a significant improvement with ParActin® treatment. At the end of the study, quality of life and Functional Assessment of Chronic Illness Therapy (FACIT) scores were significantly better in the ParActin®-treated groups compared to the control group. ParActin® and Rheumatoid Arthritis Similarly, in a randomized, double-blind and placebo-controlled study published in the journal Clinical Rheumatology in 2009, 60 individuals with compromised joints were given 100 mg of ParActin® or placebo in conjunction with methotrexate, three times a day for 14 weeks [14]. Methotrexate is proven to improve RA symptoms, but long-term use can cause serious infection and liver damage. In this study, ParActin® was effective in reducing the number and total grade of swollen joints, the number and total grade of tender joints, as well as improving scores on HAQ-52 (52-week Health Assessment Questionnaire), and SF-36 (36-item short form survey) health questionnaires. ParActin® treatment was associated with a reduction of various proteins, including enzymes, associated with cartilage damage. Currently, a human clinical trial testing the safety and efficacy of ParActin® in patients with mild to moderate osteoarthritis is ongoing. In other laboratory experiments, ParActin® and Andrographolide have also been shown to support bone [15]12, cartilage [16]13, and muscle [17]14 health and recovery. Can Andrographis Help Fight Cancer? Cancer results when our body’s cells grow uncontrollably. When cells develop normally, they become more and more specialized in their function at each stage of development. For example, immature pancreatic cells that will eventually go on to make insulin will develop the cellular machinery to do so as they become mature pancreatic cells. When cancer happens, it interferes with normal cellular development and cells do not mature. In fact, cancer cells resemble immature body cells – and the more they resemble immature cells, the more likely it is that they will spread to other locations – known as metastasis, often with fatal consequences. So, it logically follows that if cancer cells can be made to forcibly undergo maturation or differentiation, they will lose the ability to grow uncontrollably. Indeed, in one laboratory study in mice, researchers showed that Andrographis could induce differentiation in leukemia cells [18]. [Note: Leukemia is a cancer of the white blood cells, which are part of the immune system.] Andrographis can induce differentiation in laboratory conditions – but does this mean it can fight cancer? Indeed, it can – at least under laboratory conditions. A systematic review of no less than 139 pre-clinical and clinical studies shows that Andrographolide has anticancer effects on almost all types of cell lines in laboratory experiments [19]. Specifically, a 2019 study showed that Andrographolide prevented human colon cancer cells in culture from multiplying by inducing a process known as “programmed cell death” or apoptosis. Further, Andrographolide also displayed a combinatorial effect with chemotherapeutic anticancer drugs in these cells under laboratory conditions [20]. Similarly, the results of a 2019 study showed that a hot water extract of Andrographis could stimulate the production of specific components of the immune system and restore others to a more normal state. Furthermore, the Andrographis extract prevented tumor growth and metastasis in these mice, once again by inducing apoptosis, but without causing severe body weight loss as many anticancer chemotherapy drugs tend to do. Blood tests detected multiple bioactive Andrographis-derived diterpene compounds, suggesting that more than one might have contributed towards the beneficial effects seen in this study [21]. Andrographis extracts – especially bioactive lactone and diterpene compounds such as Andrographolide in them – have been shown to be very potent in suppressing the growth of various types of cancer cells in laboratory studies. In particular, Andrographolide has been shown to block the growth of human breast, prostate, and hepatoma tumors. It has even successfully been used in cancer chemotherapy [22]. Can Andrographis Help Prevent Alzheimer’s Disease? As a closing note, Andrographis is even showing promise in helping to combat Alzheimer’s disease. In a 2019 study published in the journal Plants – Basel, researchers reported that three compounds isolated from Andrographis may help stop the formation of structures known as beta-amyloid plaques, which underlie neurotoxicity and dementia, including Alzheimer’s disease [23]. As noted by the researchers “Andrographis paniculata and Spilanthes paniculata are used extensively as medicinal herbs for the treatment of various ailments, and are reported to have neuroprotective properties.”   Deeper Dive Resources   Organixx’s Turmeric T3D https://shop.organixx.com/a/secure/checkout/OobbS9ROAoETfnAGmGDF?ch-tn-box=first-box&gl=5d8908c502e26b5f0c38083c   Organixx Save & Subscribe Program https://organixx.com/subscribe-and-save/?gl=5eeaa19c8ebf588562f75d8f [1] Andrographis: In-depth review [2] Andrographolide, a Natural Antioxidant: An Update [3] Andrographis: In-depth review [4] Andrographolide, a Natural Antioxidant: An Update [5] ParActin® [6] Andrographolide, a Natural Antioxidant: An Update [7] Andrographis: In-depth review [8] Immunostimulant agents from Andrographis paniculata. [9] Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. [10] Herbal Medicine for Cough: A Systematic Review and Meta-Analysis. [11] Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. [12] HP Ingredients: ParActin Joint Health. [13] A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. [14] Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. [15] Assessment of the Efficacy of ParActin® in Subjects With Mild to Moderate Osteoarthritis (ParActin) [16] ParActin: Healthy Bone Support [17] ParActin: Healthy Cartilage Support [18] ParActin: Muscle Health and Recovery [19] Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. [20] Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. [21] Antiproliferative and Apoptotic Properties of Andrographolide Against Human Colon Cancer DLD1 Cell Line [22] Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models. [23] Andrographolide and analogues in cancer prevention. [24] Multi-Target β-Protease Inhibitors from Andrographis paniculata: In Silico and In Vitro Studies. Study builds scientific support for HP Ingredients’ ParActin for joint health https://www.nutraingredients-usa.com/Article/2019/05/08/Study-builds-scientific-support-for-HP-Ingredients-ParActin-for-joint-health   A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. https://www.ncbi.nlm.nih.gov/pubmed/30968986     Subscribe to Empowering You Organically  Never miss an episode!    APPLE PODCASTS                 SPOTIFY                 GOOGLE PODCASTS      

This “king of bitters” (so-called because of its flavor) has been used for centuries in Asia to treat gut and upper respiratory infections, fever, herpes, sore throat, and other chronic and infectious disease conditions. However, modern research is demonstrating Andrographis paniculata’s benefits include aiding with joint conditions such as arthritis. ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More The medicinal herb Andrographis paniculata has been traditionally used for its powerful anti-inflammatory properties and its ability to boost immune system activity. This “king of bitters” (so-called because of its flavor) has been used for centuries in Asia to treat gut and upper respiratory infections, fever, herpes, sore throat, and other chronic and infectious disease conditions [1]. However, modern research is demonstrating Andrographis paniculata’s benefits include aiding with joint conditions such as arthritis and it may even have anti-cancer benefits. Andrographis Goes by Many Names Andrographis is cultivated in many tropical Asian countries including India, China, Malaysia, Indonesia, and Sri Lanka, as well as in the West Indies, Brazil, parts of Africa, and Central America. Known as “chuan-xin-lian” in China, “kalmegh” in India, “senshinren” in Japan, “hempedu bumi” in Malaysia, “fah talai” in Thailand, and “green chiretta” in the Scandinavian countries, Andrographis is listed in the Indian Pharmacopoeia (a publication that lists standards for all drugs that are manufactured, sold, and consumed in India) and in a couple of dozen Ayurvedic formulas [2]. In traditional Chinese medicine (TCM), Andrographis is believed to rid the body of heat (e.g., fevers) and to dispel toxins [3]. Phytochemistry of Andrographis Paniculata Andrographis leaves are mainly responsible for its biological actions. They contain many bioactive compounds, including diterpene lactones – especially Andrographolide, the main bioactive ingredient that imparts the typical bitter taste. Andrographolide is an antioxidant that has been shown to be responsible for the herb’s anti-viral and anti-bacterial properties. Andrographolide is also reported in scientific literature to reduce blood clot formation, help protect the liver, have anti-cancer properties, and manage inflammation within safe levels [4]. What Is ParActin®? ParActin® is a patented extract of A. Paniculata, standardized to a fixed concentration of Andrographolide and other related compounds including 14-deoxyandrographolides and neoandrographolides [5]. Preliminary research shows that ParActin® promotes a healthy inflammatory response by blocking a powerful chemical known as NF-kappa B, which is known to be a key regulator of the inflammatory response system. As a result, ParActin® helps support a healthy and appropriate inflammatory response by reducing the levels of pro-inflammatory compounds that trigger the familiar pain and redness associated with inflammation. The safety and efficacy of ParActin® has been assessed in more than 30 studies, including laboratory experiments on cultured cells and animal models – and even a human clinical trial. Let’s take a closer look at some of these studies and what they tell us about Andrographis and ParActin®. Inflammation Is Linked to Many Disease Conditions Long-term, chronic inflammation that occurs when the immune system goes into overdrive may lie at the root of many otherwise unrelated diseases, including: asthma inflammatory bowel disease (IBD) rheumatoid arthritis (RA) autoimmune diseases depression cancer Alzheimer’s disease Inflammation – which manifests as swelling, redness, heat, and pain – is a normal response of our immune system and our body’s way of defending us from infections and disease. However, if it’s not managed properly, inflammation can harm the body. Chronic inflammation is the result of an overactive immune system that is constantly turned on – or cannot be turned off – so that it attacks parts of the very body it is supposed to protect. So-called oxygenated chemical species – including free radicals, oxygen ions, and peroxides – are continuously made in our body’s cells in response to UV radiation and as byproducts of ongoing metabolic activity. They are highly reactive and dangerous, because they can attack cellular DNA and proteins, damaging them. When oxygenated chemical species are generated in excess, they can overwhelm cellular defense systems, leading to a condition known as oxidative stress along with high levels of inflammation – which, as we discussed earlier, is known to contribute to the development of many diseases. Andrographolide, the best-known bioactive ingredient in Andrographis, has been shown to directly inactivate free radicals. It also protects mitochondria, blocks pro-oxidant enzymes, and activates other antioxidant enzymes in the body [6]. Andrographis Boosts the Immune System Andrographolide has been shown to enhance the immune system. For example, it boosts production of white blood cells known as lymphocytes, which scavenge and destroy bacteria and other foreign matter. It also triggers the release of signaling proteins known as interferons, along with enhancing activity of the lymphatic system [7]. Interferons are made and released by our body’s cells when they get infected with viruses, causing nearby cells to strengthen their anti-viral defenses. Interferons are potent antiviral agents that stop viruses from multiplying. The lymphatic system is another circulatory system in our body that carries a fluid known as lymph, which removes the waste products of cellular metabolism. The lymphatic system also transports invading bacteria and viruses to lymph nodes where the white blood cells (lymphocytes) destroy them. Andrographis has been shown to trigger our immune system in two ways: Antigen-specific response – specific proteins known as antibodies are made to counteract invading bacteria and viruses. Nonspecific immune response – immune cells known as macrophages are produced, which scavenge and destroy invaders. Andrographis activates both responses, meaning it is very effective against a variety of infectious and cancer-causing agents [8]. Benefits for Upper Respiratory Tract Infections & Cough Andrographis has been used for many hundreds of years in traditional medicinal systems to treat upper respiratory infections. Modern research supports this. For example, a 2004 meta-analysis of the results of seven double-blind, controlled trials (with a total of 896 participants) showed that Andrographis offers significant relief from the symptoms of upper respiratory tract infections and may even prevent them from taking hold in the first place. [Note: A meta-analysis is a quantitative epidemiological study used to systematically assess the results of previous research – typically randomized, controlled clinical trials – to derive overall conclusions about that body of research.] All the participants in these seven clinical trials reported reduced fever, runny nose, cough, and sore throat on taking Andrographis relative to control patients. Side effects were described as “generally mild and infrequent” [9]. Similarly, another meta-analysis published in 2015 reviewed six randomized controlled clinical trials, which assessed the effects of Andrographis in the treatment of cough. Combined, these six studies compared 333 patients who took various Andrographis preparations relative to 348 patients in control groups. All of these studies showed that Andrographis preparations reduced cough severity [10]. Andrographis Heals the Gut As mentioned above, Andrographis has long been used in traditional medicinal systems such as Ayurveda and traditional Chinese medicine (TCM) for treating gut infections. In a 2013 study published in the American Journal of Gastroenterology, 224 patients with mild to moderate ulcerative colitis were either given 1200 or 1800 milligrams of Andrographis for 8 weeks. Ulcerative colitis is an inflammatory bowel disease that causes long-lasting inflammation and ulcers in the gut, affecting the innermost lining of the large intestine (colon) and rectum. A colonoscopy was performed before the study started and after it ended. Stool frequency and the presence of blood in the stool were also assessed every two weeks. At the end of the study, 60% of patients who received 1800 mg of Andrographis – relative to 40% of patients in the control group – showed clinical symptoms of healing. Not only that, 50% of the patients who received the 1800 mg of Andrographis also showed mucosal healing, relative to 33% in the control group [11]. Andrographis & Joint Pain from Arthritis Arthritis affects more than 70 million Americans, leading to inflammation, pain, and stiffness in the joints and connective tissues. Over time, cartilage breaks down, bones erode, and joints become misshapen [12]. Our modern understanding is that rheumatoid arthritis (RA) happens because of the uncontrolled inflammation that is typical of an autoimmune disease. In such situations, the body’s defense mechanism malfunctions and attacks its own tissues (e.g., healthy joints) for a prolonged period of time. An immune-signaling protein known as cachexin or tumor necrosis factor-alpha is one of the key drivers of inflammation. Andrographolide has been shown to lower levels of cachexin. ParActin® and Mild Knee Osteoarthritis In a randomized, double-blind, placebo-controlled study the efficacy of ParActin® (300 and 600 mg daily) was assessed on pain reduction in 103 patients with mild to moderate knee osteoarthritis [13]. Patients treated with ParActin® showed a significant reduction in pain relative to the control group. Stiffness, physical function, and fatigue all showed a significant improvement with ParActin® treatment. At the end of the study, quality of life and Functional Assessment of Chronic Illness Therapy (FACIT) scores were significantly better in the ParActin®-treated groups compared to the control group. ParActin® and Rheumatoid Arthritis Similarly, in a randomized, double-blind and placebo-controlled study published in the journal Clinical Rheumatology in 2009, 60 individuals with compromised joints were given 100 mg of ParActin® or placebo in conjunction with methotrexate, three times a day for 14 weeks [14]. Methotrexate is proven to improve RA symptoms, but long-term use can cause serious infection and liver damage. In this study, ParActin® was effective in reducing the number and total grade of swollen joints, the number and total grade of tender joints, as well as improving scores on HAQ-52 (52-week Health Assessment Questionnaire), and SF-36 (36-item short form survey) health questionnaires. ParActin® treatment was associated with a reduction of various proteins, including enzymes, associated with cartilage damage. Currently, a human clinical trial testing the safety and efficacy of ParActin® in patients with mild to moderate osteoarthritis is ongoing. In other laboratory experiments, ParActin® and Andrographolide have also been shown to support bone [15]12, cartilage [16]13, and muscle [17]14 health and recovery. Can Andrographis Help Fight Cancer? Cancer results when our body’s cells grow uncontrollably. When cells develop normally, they become more and more specialized in their function at each stage of development. For example, immature pancreatic cells that will eventually go on to make insulin will develop the cellular machinery to do so as they become mature pancreatic cells. When cancer happens, it interferes with normal cellular development and cells do not mature. In fact, cancer cells resemble immature body cells – and the more they resemble immature cells, the more likely it is that they will spread to other locations – known as metastasis, often with fatal consequences. So, it logically follows that if cancer cells can be made to forcibly undergo maturation or differentiation, they will lose the ability to grow uncontrollably. Indeed, in one laboratory study in mice, researchers showed that Andrographis could induce differentiation in leukemia cells [18]. [Note: Leukemia is a cancer of the white blood cells, which are part of the immune system.] Andrographis can induce differentiation in laboratory conditions – but does this mean it can fight cancer? Indeed, it can – at least under laboratory conditions. A systematic review of no less than 139 pre-clinical and clinical studies shows that Andrographolide has anticancer effects on almost all types of cell lines in laboratory experiments [19]. Specifically, a 2019 study showed that Andrographolide prevented human colon cancer cells in culture from multiplying by inducing a process known as “programmed cell death” or apoptosis. Further, Andrographolide also displayed a combinatorial effect with chemotherapeutic anticancer drugs in these cells under laboratory conditions [20]. Similarly, the results of a 2019 study showed that a hot water extract of Andrographis could stimulate the production of specific components of the immune system and restore others to a more normal state. Furthermore, the Andrographis extract prevented tumor growth and metastasis in these mice, once again by inducing apoptosis, but without causing severe body weight loss as many anticancer chemotherapy drugs tend to do. Blood tests detected multiple bioactive Andrographis-derived diterpene compounds, suggesting that more than one might have contributed towards the beneficial effects seen in this study [21]. Andrographis extracts – especially bioactive lactone and diterpene compounds such as Andrographolide in them – have been shown to be very potent in suppressing the growth of various types of cancer cells in laboratory studies. In particular, Andrographolide has been shown to block the growth of human breast, prostate, and hepatoma tumors. It has even successfully been used in cancer chemotherapy [22]. Can Andrographis Help Prevent Alzheimer’s Disease? As a closing note, Andrographis is even showing promise in helping to combat Alzheimer’s disease. In a 2019 study published in the journal Plants – Basel, researchers reported that three compounds isolated from Andrographis may help stop the formation of structures known as beta-amyloid plaques, which underlie neurotoxicity and dementia, including Alzheimer’s disease [23]. As noted by the researchers “Andrographis paniculata and Spilanthes paniculata are used extensively as medicinal herbs for the treatment of various ailments, and are reported to have neuroprotective properties.”   Deeper Dive Resources   Organixx’s Turmeric T3D https://shop.organixx.com/a/secure/checkout/OobbS9ROAoETfnAGmGDF?ch-tn-box=first-box&gl=5d8908c502e26b5f0c38083c   Organixx Save & Subscribe Program https://organixx.com/subscribe-and-save/?gl=5eeaa19c8ebf588562f75d8f [1] Andrographis: In-depth review [2] Andrographolide, a Natural Antioxidant: An Update [3] Andrographis: In-depth review [4] Andrographolide, a Natural Antioxidant: An Update [5] ParActin® [6] Andrographolide, a Natural Antioxidant: An Update [7] Andrographis: In-depth review [8] Immunostimulant agents from Andrographis paniculata. [9] Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. [10] Herbal Medicine for Cough: A Systematic Review and Meta-Analysis. [11] Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. [12] HP Ingredients: ParActin Joint Health. [13] A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. [14] Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. [15] Assessment of the Efficacy of ParActin® in Subjects With Mild to Moderate Osteoarthritis (ParActin) [16] ParActin: Healthy Bone Support [17] ParActin: Healthy Cartilage Support [18] ParActin: Muscle Health and Recovery [19] Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. [20] Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. [21] Antiproliferative and Apoptotic Properties of Andrographolide Against Human Colon Cancer DLD1 Cell Line [22] Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models. [23] Andrographolide and analogues in cancer prevention. [24] Multi-Target β-Protease Inhibitors from Andrographis paniculata: In Silico and In Vitro Studies. Study builds scientific support for HP Ingredients’ ParActin for joint health https://www.nutraingredients-usa.com/Article/2019/05/08/Study-builds-scientific-support-for-HP-Ingredients-ParActin-for-joint-health   A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. https://www.ncbi.nlm.nih.gov/pubmed/30968986     Subscribe to Empowering You Organically  Never miss an episode!    APPLE PODCASTS                 SPOTIFY                 GOOGLE PODCASTS      

ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More The medicinal herb Andrographis paniculata has been traditionally used for its powerful anti-inflammatory properties and its ability to boost immune system activity. This “king of bitters” (so-called because of its flavor) has been used for centuries in Asia to treat gut and upper respiratory infections, fever, herpes, sore throat, and other chronic and infectious disease conditions [1]. However, modern research is demonstrating Andrographis paniculata’s benefits include aiding with joint conditions such as arthritis and it may even have anti-cancer benefits. Andrographis Goes by Many Names Andrographis is cultivated in many tropical Asian countries including India, China, Malaysia, Indonesia, and Sri Lanka, as well as in the West Indies, Brazil, parts of Africa, and Central America. Known as “chuan-xin-lian” in China, “kalmegh” in India, “senshinren” in Japan, “hempedu bumi” in Malaysia, “fah talai” in Thailand, and “green chiretta” in the Scandinavian countries, Andrographis is listed in the Indian Pharmacopoeia (a publication that lists standards for all drugs that are manufactured, sold, and consumed in India) and in a couple of dozen Ayurvedic formulas [2]. In traditional Chinese medicine (TCM), Andrographis is believed to rid the body of heat (e.g., fevers) and to dispel toxins [3]. Phytochemistry of Andrographis Paniculata Andrographis leaves are mainly responsible for its biological actions. They contain many bioactive compounds, including diterpene lactones – especially Andrographolide, the main bioactive ingredient that imparts the typical bitter taste. Andrographolide is an antioxidant that has been shown to be responsible for the herb’s anti-viral and anti-bacterial properties. Andrographolide is also reported in scientific literature to reduce blood clot formation, help protect the liver, have anti-cancer properties, and manage inflammation within safe levels [4]. What Is ParActin®? ParActin® is a patented extract of A. Paniculata, standardized to a fixed concentration of Andrographolide and other related compounds including 14-deoxyandrographolides and neoandrographolides [5]. Preliminary research shows that ParActin® promotes a healthy inflammatory response by blocking a powerful chemical known as NF-kappa B, which is known to be a key regulator of the inflammatory response system. As a result, ParActin® helps support a healthy and appropriate inflammatory response by reducing the levels of pro-inflammatory compounds that trigger the familiar pain and redness associated with inflammation. The safety and efficacy of ParActin® has been assessed in more than 30 studies, including laboratory experiments on cultured cells and animal models – and even a human clinical trial. Let’s take a closer look at some of these studies and what they tell us about Andrographis and ParActin®. Inflammation Is Linked to Many Disease Conditions Long-term, chronic inflammation that occurs when the immune system goes into overdrive may lie at the root of many otherwise unrelated diseases, including: asthma inflammatory bowel disease (IBD) rheumatoid arthritis (RA) autoimmune diseases depression cancer Alzheimer’s disease Inflammation – which manifests as swelling, redness, heat, and pain – is a normal response of our immune system and our body’s way of defending us from infections and disease. However, if it’s not managed properly, inflammation can harm the body. Chronic inflammation is the result of an overactive immune system that is constantly turned on – or cannot be turned off – so that it attacks parts of the very body it is supposed to protect. So-called oxygenated chemical species – including free radicals, oxygen ions, and peroxides – are continuously made in our body’s cells in response to UV radiation and as byproducts of ongoing metabolic activity. They are highly reactive and dangerous, because they can attack cellular DNA and proteins, damaging them. When oxygenated chemical species are generated in excess, they can overwhelm cellular defense systems, leading to a condition known as oxidative stress along with high levels of inflammation – which, as we discussed earlier, is known to contribute to the development of many diseases. Andrographolide, the best-known bioactive ingredient in Andrographis, has been shown to directly inactivate free radicals. It also protects mitochondria, blocks pro-oxidant enzymes, and activates other antioxidant enzymes in the body [6]. Andrographis Boosts the Immune System Andrographolide has been shown to enhance the immune system. For example, it boosts production of white blood cells known as lymphocytes, which scavenge and destroy bacteria and other foreign matter. It also triggers the release of signaling proteins known as interferons, along with enhancing activity of the lymphatic system [7]. Interferons are made and released by our body’s cells when they get infected with viruses, causing nearby cells to strengthen their anti-viral defenses. Interferons are potent antiviral agents that stop viruses from multiplying. The lymphatic system is another circulatory system in our body that carries a fluid known as lymph, which removes the waste products of cellular metabolism. The lymphatic system also transports invading bacteria and viruses to lymph nodes where the white blood cells (lymphocytes) destroy them. Andrographis has been shown to trigger our immune system in two ways: Antigen-specific response – specific proteins known as antibodies are made to counteract invading bacteria and viruses. Nonspecific immune response – immune cells known as macrophages are produced, which scavenge and destroy invaders. Andrographis activates both responses, meaning it is very effective against a variety of infectious and cancer-causing agents [8]. Benefits for Upper Respiratory Tract Infections & Cough Andrographis has been used for many hundreds of years in traditional medicinal systems to treat upper respiratory infections. Modern research supports this. For example, a 2004 meta-analysis of the results of seven double-blind, controlled trials (with a total of 896 participants) showed that Andrographis offers significant relief from the symptoms of upper respiratory tract infections and may even prevent them from taking hold in the first place. [Note: A meta-analysis is a quantitative epidemiological study used to systematically assess the results of previous research – typically randomized, controlled clinical trials – to derive overall conclusions about that body of research.] All the participants in these seven clinical trials reported reduced fever, runny nose, cough, and sore throat on taking Andrographis relative to control patients. Side effects were described as “generally mild and infrequent” [9]. Similarly, another meta-analysis published in 2015 reviewed six randomized controlled clinical trials, which assessed the effects of Andrographis in the treatment of cough. Combined, these six studies compared 333 patients who took various Andrographis preparations relative to 348 patients in control groups. All of these studies showed that Andrographis preparations reduced cough severity [10]. Andrographis Heals the Gut As mentioned above, Andrographis has long been used in traditional medicinal systems such as Ayurveda and traditional Chinese medicine (TCM) for treating gut infections. In a 2013 study published in the American Journal of Gastroenterology, 224 patients with mild to moderate ulcerative colitis were either given 1200 or 1800 milligrams of Andrographis for 8 weeks. Ulcerative colitis is an inflammatory bowel disease that causes long-lasting inflammation and ulcers in the gut, affecting the innermost lining of the large intestine (colon) and rectum. A colonoscopy was performed before the study started and after it ended. Stool frequency and the presence of blood in the stool were also assessed every two weeks. At the end of the study, 60% of patients who received 1800 mg of Andrographis – relative to 40% of patients in the control group – showed clinical symptoms of healing. Not only that, 50% of the patients who received the 1800 mg of Andrographis also showed mucosal healing, relative to 33% in the control group [11]. Andrographis & Joint Pain from Arthritis Arthritis affects more than 70 million Americans, leading to inflammation, pain, and stiffness in the joints and connective tissues. Over time, cartilage breaks down, bones erode, and joints become misshapen [12]. Our modern understanding is that rheumatoid arthritis (RA) happens because of the uncontrolled inflammation that is typical of an autoimmune disease. In such situations, the body’s defense mechanism malfunctions and attacks its own tissues (e.g., healthy joints) for a prolonged period of time. An immune-signaling protein known as cachexin or tumor necrosis factor-alpha is one of the key drivers of inflammation. Andrographolide has been shown to lower levels of cachexin. ParActin® and Mild Knee Osteoarthritis In a randomized, double-blind, placebo-controlled study the efficacy of ParActin® (300 and 600 mg daily) was assessed on pain reduction in 103 patients with mild to moderate knee osteoarthritis [13]. Patients treated with ParActin® showed a significant reduction in pain relative to the control group. Stiffness, physical function, and fatigue all showed a significant improvement with ParActin® treatment. At the end of the study, quality of life and Functional Assessment of Chronic Illness Therapy (FACIT) scores were significantly better in the ParActin®-treated groups compared to the control group. ParActin® and Rheumatoid Arthritis Similarly, in a randomized, double-blind and placebo-controlled study published in the journal Clinical Rheumatology in 2009, 60 individuals with compromised joints were given 100 mg of ParActin® or placebo in conjunction with methotrexate, three times a day for 14 weeks [14]. Methotrexate is proven to improve RA symptoms, but long-term use can cause serious infection and liver damage. In this study, ParActin® was effective in reducing the number and total grade of swollen joints, the number and total grade of tender joints, as well as improving scores on HAQ-52 (52-week Health Assessment Questionnaire), and SF-36 (36-item short form survey) health questionnaires. ParActin® treatment was associated with a reduction of various proteins, including enzymes, associated with cartilage damage. Currently, a human clinical trial testing the safety and efficacy of ParActin® in patients with mild to moderate osteoarthritis is ongoing. In other laboratory experiments, ParActin® and Andrographolide have also been shown to support bone [15]12, cartilage [16]13, and muscle [17]14 health and recovery. Can Andrographis Help Fight Cancer? Cancer results when our body’s cells grow uncontrollably. When cells develop normally, they become more and more specialized in their function at each stage of development. For example, immature pancreatic cells that will eventually go on to make insulin will develop the cellular machinery to do so as they become mature pancreatic cells. When cancer happens, it interferes with normal cellular development and cells do not mature. In fact, cancer cells resemble immature body cells – and the more they resemble immature cells, the more likely it is that they will spread to other locations – known as metastasis, often with fatal consequences. So, it logically follows that if cancer cells can be made to forcibly undergo maturation or differentiation, they will lose the ability to grow uncontrollably. Indeed, in one laboratory study in mice, researchers showed that Andrographis could induce differentiation in leukemia cells [18]. [Note: Leukemia is a cancer of the white blood cells, which are part of the immune system.] Andrographis can induce differentiation in laboratory conditions – but does this mean it can fight cancer? Indeed, it can – at least under laboratory conditions. A systematic review of no less than 139 pre-clinical and clinical studies shows that Andrographolide has anticancer effects on almost all types of cell lines in laboratory experiments [19]. Specifically, a 2019 study showed that Andrographolide prevented human colon cancer cells in culture from multiplying by inducing a process known as “programmed cell death” or apoptosis. Further, Andrographolide also displayed a combinatorial effect with chemotherapeutic anticancer drugs in these cells under laboratory conditions [20]. Similarly, the results of a 2019 study showed that a hot water extract of Andrographis could stimulate the production of specific components of the immune system and restore others to a more normal state. Furthermore, the Andrographis extract prevented tumor growth and metastasis in these mice, once again by inducing apoptosis, but without causing severe body weight loss as many anticancer chemotherapy drugs tend to do. Blood tests detected multiple bioactive Andrographis-derived diterpene compounds, suggesting that more than one might have contributed towards the beneficial effects seen in this study [21]. Andrographis extracts – especially bioactive lactone and diterpene compounds such as Andrographolide in them – have been shown to be very potent in suppressing the growth of various types of cancer cells in laboratory studies. In particular, Andrographolide has been shown to block the growth of human breast, prostate, and hepatoma tumors. It has even successfully been used in cancer chemotherapy [22]. Can Andrographis Help Prevent Alzheimer’s Disease? As a closing note, Andrographis is even showing promise in helping to combat Alzheimer’s disease. In a 2019 study published in the journal Plants – Basel, researchers reported that three compounds isolated from Andrographis may help stop the formation of structures known as beta-amyloid plaques, which underlie neurotoxicity and dementia, including Alzheimer’s disease [23]. As noted by the researchers “Andrographis paniculata and Spilanthes paniculata are used extensively as medicinal herbs for the treatment of various ailments, and are reported to have neuroprotective properties.”

ParActin®: A Potent Form of Andrographis Paniculata for Pain Support & More The medicinal herb Andrographis paniculata has been traditionally used for its powerful anti-inflammatory properties and its ability to boost immune system activity. This “king of bitters” (so-called because of its flavor) has been used for centuries in Asia to treat gut and upper respiratory infections, fever, herpes, sore throat, and other chronic and infectious disease conditions [1]. However, modern research is demonstrating Andrographis paniculata’s benefits include aiding with joint conditions such as arthritis and it may even have anti-cancer benefits. Andrographis Goes by Many Names Andrographis is cultivated in many tropical Asian countries including India, China, Malaysia, Indonesia, and Sri Lanka, as well as in the West Indies, Brazil, parts of Africa, and Central America. Known as “chuan-xin-lian” in China, “kalmegh” in India, “senshinren” in Japan, “hempedu bumi” in Malaysia, “fah talai” in Thailand, and “green chiretta” in the Scandinavian countries, Andrographis is listed in the Indian Pharmacopoeia (a publication that lists standards for all drugs that are manufactured, sold, and consumed in India) and in a couple of dozen Ayurvedic formulas [2]. In traditional Chinese medicine (TCM), Andrographis is believed to rid the body of heat (e.g., fevers) and to dispel toxins [3]. Phytochemistry of Andrographis Paniculata Andrographis leaves are mainly responsible for its biological actions. They contain many bioactive compounds, including diterpene lactones – especially Andrographolide, the main bioactive ingredient that imparts the typical bitter taste. Andrographolide is an antioxidant that has been shown to be responsible for the herb’s anti-viral and anti-bacterial properties. Andrographolide is also reported in scientific literature to reduce blood clot formation, help protect the liver, have anti-cancer properties, and manage inflammation within safe levels [4]. What Is ParActin®? ParActin® is a patented extract of A. Paniculata, standardized to a fixed concentration of Andrographolide and other related compounds including 14-deoxyandrographolides and neoandrographolides [5]. Preliminary research shows that ParActin® promotes a healthy inflammatory response by blocking a powerful chemical known as NF-kappa B, which is known to be a key regulator of the inflammatory response system. As a result, ParActin® helps support a healthy and appropriate inflammatory response by reducing the levels of pro-inflammatory compounds that trigger the familiar pain and redness associated with inflammation. The safety and efficacy of ParActin® has been assessed in more than 30 studies, including laboratory experiments on cultured cells and animal models – and even a human clinical trial. Let’s take a closer look at some of these studies and what they tell us about Andrographis and ParActin®. Inflammation Is Linked to Many Disease Conditions Long-term, chronic inflammation that occurs when the immune system goes into overdrive may lie at the root of many otherwise unrelated diseases, including: asthma inflammatory bowel disease (IBD) rheumatoid arthritis (RA) autoimmune diseases depression cancer Alzheimer’s disease Inflammation – which manifests as swelling, redness, heat, and pain – is a normal response of our immune system and our body’s way of defending us from infections and disease. However, if it’s not managed properly, inflammation can harm the body. Chronic inflammation is the result of an overactive immune system that is constantly turned on – or cannot be turned off – so that it attacks parts of the very body it is supposed to protect. So-called oxygenated chemical species – including free radicals, oxygen ions, and peroxides – are continuously made in our body’s cells in response to UV radiation and as byproducts of ongoing metabolic activity. They are highly reactive and dangerous, because they can attack cellular DNA and proteins, damaging them. When oxygenated chemical species are generated in excess, they can overwhelm cellular defense systems, leading to a condition known as oxidative stress along with high levels of inflammation – which, as we discussed earlier, is known to contribute to the development of many diseases. Andrographolide, the best-known bioactive ingredient in Andrographis, has been shown to directly inactivate free radicals. It also protects mitochondria, blocks pro-oxidant enzymes, and activates other antioxidant enzymes in the body [6]. Andrographis Boosts the Immune System Andrographolide has been shown to enhance the immune system. For example, it boosts production of white blood cells known as lymphocytes, which scavenge and destroy bacteria and other foreign matter. It also triggers the release of signaling proteins known as interferons, along with enhancing activity of the lymphatic system [7]. Interferons are made and released by our body’s cells when they get infected with viruses, causing nearby cells to strengthen their anti-viral defenses. Interferons are potent antiviral agents that stop viruses from multiplying. The lymphatic system is another circulatory system in our body that carries a fluid known as lymph, which removes the waste products of cellular metabolism. The lymphatic system also transports invading bacteria and viruses to lymph nodes where the white blood cells (lymphocytes) destroy them. Andrographis has been shown to trigger our immune system in two ways: Antigen-specific response – specific proteins known as antibodies are made to counteract invading bacteria and viruses. Nonspecific immune response – immune cells known as macrophages are produced, which scavenge and destroy invaders. Andrographis activates both responses, meaning it is very effective against a variety of infectious and cancer-causing agents [8]. Benefits for Upper Respiratory Tract Infections & Cough Andrographis has been used for many hundreds of years in traditional medicinal systems to treat upper respiratory infections. Modern research supports this. For example, a 2004 meta-analysis of the results of seven double-blind, controlled trials (with a total of 896 participants) showed that Andrographis offers significant relief from the symptoms of upper respiratory tract infections and may even prevent them from taking hold in the first place. [Note: A meta-analysis is a quantitative epidemiological study used to systematically assess the results of previous research – typically randomized, controlled clinical trials – to derive overall conclusions about that body of research.] All the participants in these seven clinical trials reported reduced fever, runny nose, cough, and sore throat on taking Andrographis relative to control patients. Side effects were described as “generally mild and infrequent” [9]. Similarly, another meta-analysis published in 2015 reviewed six randomized controlled clinical trials, which assessed the effects of Andrographis in the treatment of cough. Combined, these six studies compared 333 patients who took various Andrographis preparations relative to 348 patients in control groups. All of these studies showed that Andrographis preparations reduced cough severity [10]. Andrographis Heals the Gut As mentioned above, Andrographis has long been used in traditional medicinal systems such as Ayurveda and traditional Chinese medicine (TCM) for treating gut infections. In a 2013 study published in the American Journal of Gastroenterology, 224 patients with mild to moderate ulcerative colitis were either given 1200 or 1800 milligrams of Andrographis for 8 weeks. Ulcerative colitis is an inflammatory bowel disease that causes long-lasting inflammation and ulcers in the gut, affecting the innermost lining of the large intestine (colon) and rectum. A colonoscopy was performed before the study started and after it ended. Stool frequency and the presence of blood in the stool were also assessed every two weeks. At the end of the study, 60% of patients who received 1800 mg of Andrographis – relative to 40% of patients in the control group – showed clinical symptoms of healing. Not only that, 50% of the patients who received the 1800 mg of Andrographis also showed mucosal healing, relative to 33% in the control group [11]. Andrographis & Joint Pain from Arthritis Arthritis affects more than 70 million Americans, leading to inflammation, pain, and stiffness in the joints and connective tissues. Over time, cartilage breaks down, bones erode, and joints become misshapen [12]. Our modern understanding is that rheumatoid arthritis (RA) happens because of the uncontrolled inflammation that is typical of an autoimmune disease. In such situations, the body’s defense mechanism malfunctions and attacks its own tissues (e.g., healthy joints) for a prolonged period of time. An immune-signaling protein known as cachexin or tumor necrosis factor-alpha is one of the key drivers of inflammation. Andrographolide has been shown to lower levels of cachexin. ParActin® and Mild Knee Osteoarthritis In a randomized, double-blind, placebo-controlled study the efficacy of ParActin® (300 and 600 mg daily) was assessed on pain reduction in 103 patients with mild to moderate knee osteoarthritis [13]. Patients treated with ParActin® showed a significant reduction in pain relative to the control group. Stiffness, physical function, and fatigue all showed a significant improvement with ParActin® treatment. At the end of the study, quality of life and Functional Assessment of Chronic Illness Therapy (FACIT) scores were significantly better in the ParActin®-treated groups compared to the control group. ParActin® and Rheumatoid Arthritis Similarly, in a randomized, double-blind and placebo-controlled study published in the journal Clinical Rheumatology in 2009, 60 individuals with compromised joints were given 100 mg of ParActin® or placebo in conjunction with methotrexate, three times a day for 14 weeks [14]. Methotrexate is proven to improve RA symptoms, but long-term use can cause serious infection and liver damage. In this study, ParActin® was effective in reducing the number and total grade of swollen joints, the number and total grade of tender joints, as well as improving scores on HAQ-52 (52-week Health Assessment Questionnaire), and SF-36 (36-item short form survey) health questionnaires. ParActin® treatment was associated with a reduction of various proteins, including enzymes, associated with cartilage damage. Currently, a human clinical trial testing the safety and efficacy of ParActin® in patients with mild to moderate osteoarthritis is ongoing. In other laboratory experiments, ParActin® and Andrographolide have also been shown to support bone [15]12, cartilage [16]13, and muscle [17]14 health and recovery. Can Andrographis Help Fight Cancer? Cancer results when our body’s cells grow uncontrollably. When cells develop normally, they become more and more specialized in their function at each stage of development. For example, immature pancreatic cells that will eventually go on to make insulin will develop the cellular machinery to do so as they become mature pancreatic cells. When cancer happens, it interferes with normal cellular development and cells do not mature. In fact, cancer cells resemble immature body cells – and the more they resemble immature cells, the more likely it is that they will spread to other locations – known as metastasis, often with fatal consequences. So, it logically follows that if cancer cells can be made to forcibly undergo maturation or differentiation, they will lose the ability to grow uncontrollably. Indeed, in one laboratory study in mice, researchers showed that Andrographis could induce differentiation in leukemia cells [18]. [Note: Leukemia is a cancer of the white blood cells, which are part of the immune system.] Andrographis can induce differentiation in laboratory conditions – but does this mean it can fight cancer? Indeed, it can – at least under laboratory conditions. A systematic review of no less than 139 pre-clinical and clinical studies shows that Andrographolide has anticancer effects on almost all types of cell lines in laboratory experiments [19]. Specifically, a 2019 study showed that Andrographolide prevented human colon cancer cells in culture from multiplying by inducing a process known as “programmed cell death” or apoptosis. Further, Andrographolide also displayed a combinatorial effect with chemotherapeutic anticancer drugs in these cells under laboratory conditions [20]. Similarly, the results of a 2019 study showed that a hot water extract of Andrographis could stimulate the production of specific components of the immune system and restore others to a more normal state. Furthermore, the Andrographis extract prevented tumor growth and metastasis in these mice, once again by inducing apoptosis, but without causing severe body weight loss as many anticancer chemotherapy drugs tend to do. Blood tests detected multiple bioactive Andrographis-derived diterpene compounds, suggesting that more than one might have contributed towards the beneficial effects seen in this study [21]. Andrographis extracts – especially bioactive lactone and diterpene compounds such as Andrographolide in them – have been shown to be very potent in suppressing the growth of various types of cancer cells in laboratory studies. In particular, Andrographolide has been shown to block the growth of human breast, prostate, and hepatoma tumors. It has even successfully been used in cancer chemotherapy [22]. Can Andrographis Help Prevent Alzheimer’s Disease? As a closing note, Andrographis is even showing promise in helping to combat Alzheimer’s disease. In a 2019 study published in the journal Plants – Basel, researchers reported that three compounds isolated from Andrographis may help stop the formation of structures known as beta-amyloid plaques, which underlie neurotoxicity and dementia, including Alzheimer’s disease [23]. As noted by the researchers “Andrographis paniculata and Spilanthes paniculata are used extensively as medicinal herbs for the treatment of various ailments, and are reported to have neuroprotective properties.”

An episode talking about how one can be of support to a person hurting (physically or mentally), on holding space for one another, self-care and the start of a support group. If you wish to join the support group, email me at aditi.mahajan@icloud.com or message me on Instagram-@addi.mahajan

We're placing a spotlight under chronic pain group visits. As a loyal follower of the show, you know that we tackle and raise awareness around some of the biggest and most important topics and issues affecting pain science, pain care and chronic disease. Our guest is passionate about a single solution to the biggest challenges facing healthcare and how it can eliminate the chronic disease, escalating costs, practitioner shortages, quality care affordability access, practitioner burnout, loneliness, and the physical and mental health conditions we see now. That solution is the healthcare system that functions from a group visit model. Our guest is my good friend, James Maskell. James is the host of a podcast and a show called the Functional Forum, which has become the world's largest integrative medicine community. He's on a mission to create structures necessary to evolve humanity beyond chronic disease, including chronic pain. He lectures internationally and has been featured on TEDx, TEDMED, the Huffington Post, and is also the Founder of Knew Health, a payer solution for chronic disease reversal. In this episode, James will provide you with the guide to creating and structuring group visits including how they originated, what they are, how to run them, how to avoid pitfalls and overcome challenges. Also, best practices for launching and facilitating a group visit, as well as online and digital tools for ongoing support. James will also discuss his book on the episode, which is called The Community Cure. It's an excellent resource if you're interested in group visits, how to structure them and how to get reimbursed for them. You can download that book by going to www.TheCommunityCure.com. I highly recommend you download it and grab your copy. Let's begin and let's learn all about group visits with James Maskell.   Sign up for the latest episode at www.integrativepainscienceinstitute.com/podcasts/. Love the show? Subscribe, rate, review, and share! Here’s How » Join the Healing Pain Podcast Community today: integrativepainsciencinstitute.com Healing Pain Podcast Facebook Healing Pain Podcast Twitter Healing Pain Podcast YouTube Healing Pain Podcast LinkedIn Healing Pain Podcast Instagram

Episode 194 - Understanding his Pain --- Support this podcast: https://anchor.fm/thepsychicproject/support

Today’s episode features the one and only Maria Noel Groves! Listen in as she covers lots of ground, she talks about many herbs from her new book, Grow Your Own Herbal Remedies. This episode was a keynote she gave at the 2019 NHMGAA Spring Symposium. Get a signed copy of Maria’s new book, Grow Your Own Herbal Remedies (plus an astonishing amount of bonus goodies) Bonus access will be emailed to you automatically on all orders placed through Maria (not on Amazon, etc.) before April 30. Bonus e-Books contain... In-Depth Book Overview Including Easy Reference Lists of Recipes & Plants Covered Quick Guide to Medicinal Uses of Common Culinary Herbs Additional Plant Profiles of Alder, Aloe, Evergreens, Magnolia, New England Aster, Peach, Witch Hazel "Bonus Chapter" on Medicinal Mushrooms including Growing, Wildcrafting, Processing, Recipes, and Profiles on Reishi, Shiitake, Turkey Tails, Chaga, and Maitake Huge Chart Overview of Growing Needs and Habits of ALL the Plants Covered in the Book and Bonus e-Book Four Special Remedy Making Videos Featuring Recipes from the Book! From the Tummy Soothing Garden ~ Tea: Gut Healing Tummy Tea Take 1, Marshmallow Overnight Cold Infusion (with some amazingly tasty additions!) From the Brain Boosting Garden ~ Tincture & Teas: Rosemary Fresh Plant Tincture, Fresh Rosemary-Lemon Tea, Minty Memory Tea From the Immune SOS Garden ~ Elderberry Syrup & Oxymel: Darcey Blue's Amazing Elderberry Syrup, Alcohol-Free Elder-Rosehip Oxymel Also from the Brain Boosting Garden ~ Powders & Bonbons: How to Powder Your Own Herbs, Brainiac Bonbons (honey-nut butter-herb balls) Special Seed Coupon from Strictly Medicinal Seeds $5 off your seed order of $50 or more - AMAZING selection! Expires April 30. 10% off One of Maria's Online Herbal Study Course Series Applicable for the full Home Herbalist Series OR the Beyond the Home  Herbalist Series Expires April 30. LEARN MORE   Thanks for listening! HerbRally www.herbrally.com Breitenbush Herbal Conference www.herbalconference.net 

The descent of the sons of Israel into Egypt demonstrates how to give meaning your pain: [Exodus 1:1, 5 RSV] "1 These are the names of the sons of Israel who came to Egypt with Jacob, each with his household:" The first Torah portion of the book of Exodus, Parashah Shemot, shows the horrors of enslavement for the Jewish people. Shemot is also the Hebrew name for the second book of the Bible. The word, Shemot means Names. It is through the “Names” God gave His people that they emerged victorious out of their cruel bondage and subjugation. Jacob’s sons are listed to stress that the Jews did not replace their Jewish names with Egyptian ones, signifying that they refused total assimilation into Egyptian culture. By listing their names, God is emphasizing how precious His people are to Him. In exile, the Israelites actualized their ability to overcome darkness and gave meaning to their pain. Even as the Children of Israel emerged victorious from the Egyptian exile, you too will emerge victorious from the tribulations of your life. It is through the process of exile that God will bring forth your hidden potential. In this study, you will forsake your Egyptian (mitzrayim) mindsets of limitation and emerge with new purpose as you embrace your destiny which is your high calling in Christ Jesus: [Philippians 3:14 RSV] "14 I press on toward the goal for the prize of the upward call of God in Christ Jesus." Join us for “How to give Meaning to your Pain” --- Support this podcast: https://anchor.fm/destined4torah/support

The Gift of God’s Love • Finding Purpose in the Pain --- Support this podcast: https://anchor.fm/The-Herban-Rebel/support

Push Past the Pain --- Support this podcast: https://anchor.fm/The-Herban-Rebel/support

Host Dr. Kevin Passero and his special guest Jackson Corley will be discussing the benefits of IncrediBraces for circulation and pain support. In 2008, Dr. Jackson Corley, a certified chiropractor and extreme-sports enthusiast, was mountain biking in Upper Bidwell Park. He crashed and fell down a 15-foot ravine, herniating five discs and severely injuring his legs. In lieu of surgery, he invented special socks called Incredisocks and a back brace called the Incredibrace using materials that vastly improved blood and oxygen flow and relieved his pain. He’s since modified the Incredibrace to include wrist and knee braces. In less than two years on the market, his Incrediwear products are catching fire worldwide.

What facial expressions in mice can tell us about pain, managing pain in dementia patients, and finding hope in a pain support group. First broadcast 13.12.11 People with mental illness and chronic pain often find it difficult to access the treatment they need. Specialist nurse Valerie Conway talks about her work in providing carers with the skills to better look after people with Alzheimer’s and dementia who have pain. Measuring pain through facial expressions is one way in which health professionals can become more aware of the needs of those who are unable to verbalise their experience. Professor Jeffrey Mogil tells Airing Pain about his work measuring pain responses in the facial expressions of mice and how this could help in understanding human pain and in finding new drug treatments for pain. We also hear from Sue Clayton about how sharing her experiences and getting pain management advice at a pioneering chronic pain support group in the eighties helped her put her life back together after post-surgical pain. In this programme: * Valerie Conway, Clinical Lead, NHS Community Services Chronic Pain, Kent * Prof Jeffrey Mogil, Professor of Pain Studies, McGill University * Sue Clayton, past member of BPS patient liaison #AbleRadio #AiringPain #PainConcern

Join Lisa and some special volunteers from Rest Ministries for a time of encouragement.

Join Lisa and some special volunteers from Rest Ministries for a time of encouragement.