Healthcare Unfiltered

Dr. Vivek Subbiah returns for another edition of Vivek's Takes, offering his expert insights on the standout science from the 2025 ASCO Annual Meeting. He breaks down key developments including trispecific antibodies, the growing role of radioligand therapies, a new standard of care in small cell lung cancer, and paradigm-shifting data in adjuvant therapy for colorectal cancer. The discussion also highlights a long-term exercise intervention, adjuvant vaccine studies, ctDNA and MRD integration, resistance mechanisms, artificial intelligence, and other emerging trends shaping the future of oncology. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dena Marrinucci, PhD, co-founder and COO of Truvian Health, joins the show to discuss her mission to transform blood diagnostics through a point-of-care device that delivers rapid, actionable results. She shares the origin story of founding Truvian in 2015—coincidentally just weeks before the Theranos exposé—and reflects on navigating industry skepticism in the post-Theranos landscape. Marrinucci also outlines the company's FDA submission process, the importance of empowering immediate patient-provider decision-making, and what the initial panel of 30+ lab tests offers for routine care, among so much more. Read the article on the Truvian Health blood test. https://www.newsweek.com/truvian-lab-company-blood-test-device-theranos-health-care-1997422 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Former FDA Commissioner Robert Califf returns to the show for an in-depth discussion on the integration of artificial intelligence into regulatory processes, including how AI is currently being used—and should be used—in drug and medical device approvals, the detection and review of fraudulent data, and clinical decision support systems. He also explores the boundaries between algorithmic automation and human judgment, emphasizing the importance of maintaining transparency, accountability, and trust in an increasingly data-driven regulatory landscape. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Last week, Chadi and researchers explored the KETO-CTA study, which investigated the effects of the ketogenic diet on coronary plaque formation in Lean Mass Hyper-Responders (LMHR), or individuals who experience significant LDL cholesterol elevations on low-carb diets. This week, the other side of the conversation is presented. A leading cardiologist joins the show to critically examine the KETO-CTA study findings, questioning their clinical significance and broader applicability. What do these results really mean for cardiovascular risk in the general population? Should elevated LDL in the context of good metabolic health be treated the same as traditional hyperlipidemia? This episode dives into the nuances of lipidology, the role of LDL in atherosclerosis, and the complexity of applying study findings to real-world patients. Whether you're a clinician, researcher, or just interested in the science behind diet and heart health, this conversation is essential listening. View the KETO-CTA study. https://www.sciencedirect.com/science/article/pii/S2772963X25001036 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

The ketogenic (keto) diet has surged in popularity, with many touting its weight loss and metabolic benefits. However, some individuals—particularly those following a low-carb, high-fat regimen—experience a significant rise in LDL cholesterol, a phenomenon now known as the Lean Mass Hyper-Responder (LMHR) phenotype. What does this mean for cardiovascular risk? In this episode, Chadi is joined by three of the lead investigators of the KETO-CTA study, recently published in The American Journal of Clinical Nutrition. They break down their findings on how the keto diet affects coronary plaque formation and what it could mean for LMHR individuals. This is Part 1 of a two-part series. Next week, Chadi brings in a contrasting perspective on the study's conclusions. A must-listen series for anyone interested in the intersection of diet, cholesterol, and cardiovascular health. View the KETO-CTA study. https://www.sciencedirect.com/science/article/pii/S2772963X25001036 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Cardiologists Andrew Foy and Anish Koka return to the show for a deep and often contentious debate on one of the most pressing healthcare policy issues of our time: should the government negotiate drug prices? Using the Inflation Reduction Act (IRA) as a springboard, the conversation explores the underlying causes of inflated drug prices in the US, including the role of third-party payers, lack of transparency, and market distortions. The discussion also examines the global landscape—how other countries manage drug pricing—and whether those models offer lessons or cautionary tales. What impact will the IRA have on patients, access, and innovation? Can payers do more to control costs without sacrificing care? This episode dives into the complexities of healthcare economics, the free market, and the question of whether government intervention helps or hinders progress. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

With over 513,000 licensed advanced practice providers (APPs) in the U.S.—including 355,000 nurse practitioners and 158,470 physician assistants—and a projected 31% growth in the next five years, APPs are playing an increasingly vital role in oncology care. In this episode, Chadi is joined by Mary DiLorenzo and Clare Stone, two seasoned APPs practicing in North Carolina, for an in-depth conversation about how the field has evolved over the past 10–15 years. Together, they explore the nuances of APP scope of practice, how responsibilities vary across institutions and physician teams, and the ways in which APPs are integrated across inpatient and outpatient settings. The discussion also dives into critical questions: Are APPs seeing new patients as well as follow-ups? Could they eventually replace oncologists in some roles? What happens when clinical opinions diverge between APPs and physicians? Why do some patients feel more comfortable opening up to their APP than their oncologist? This episode offers a timely look at how APPs are shaping the future of cancer care delivery. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. Emil Lou and Shruti Patel join Chadi on the podcast to unpack the alarming rise of gastrointestinal cancers in younger patients. They explore a range of possible environmental contributors—from plastic exposure and processed meats to alcohol and tobacco use—and discuss how these factors might be investigated through laboratory science. The conversation also highlights the promise of genomic profiling in shedding light on these trends, and reviews key findings from ASCO GI that could help steer future research and prevention efforts. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. Sanam Loghavi and Amer Zeidan delve into the history behind the recent classification split between the World Health Organization (WHO) and the International Consensus Classification (ICC) for myeloid and lymphoid malignancies, and how a few years of minor disagreement have culminated in a unified system. They explore the critical differences in how myeloid and lymphoid neoplasms are now categorized, what this alignment means for pathologists, oncologists, regulators, and patients, when the new classification will take effect, and how it is expected to influence research, diagnosis, and clinical care. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Where does AI truly fit into the future of biomedicine and healthcare, beyond the usual headlines in radiology and pathology? Jonathan Carlson, Managing Director of Research Health Futures at Microsoft, joins the show to explore the evolution of AI in medicine, from the early days to cutting-edge innovations like ambient clinical intelligence. Together, he and Chadi unpack how pretrained models and machine learning are transforming care delivery, as well as the ethical and practical questions we need to be asking now. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

A Georgia court recently awarded over $2 billion to a plaintiff who developed lymphoma due to Monsanto's Roundup exposure, but a new bill could prevent future victims from suing the company. Patient advocate Kelly Ryerson unpacks the legal maneuvering behind this legislation, its potential impact on consumer rights, and what it means for the future of environmental and food safety. Don't miss this critical discussion on the intersection of law, public health, and corporate accountability. For more on this, check out this article. https://www.thecentersquare.com/georgia/article_2065b5e4-1052-433d-9af8-d840389e722d.html View Kelly's website. https://glyphosatefacts.com/about/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Simrit Parmar, founder of Cellenkos, joins the show to discuss her journey from the lab to the biotech startup world, detailing the inspiration behind launching her company, the challenges of securing funding, and the resilience required to overcome rejections. She shares insights into Cellenkos' lead product, its progress toward market approval, and the rigorous process of demonstrating safety and efficacy to the FDA. Additionally, she provides a glimpse into the company's pipeline of innovative cellular therapies aimed at addressing unmet medical needs. Find out more about Cellenkos. https://cellenkosinc.com/about/index.html Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Carol Rausch—a healthcare professional, cancer researcher, and former patient with lymphoma—shares how her journey from researcher to patient transformed her understanding of medical language. She discusses the impact of word choice on patients, why certain battle and war metaphors can be harmful, and how language used in clinical settings differs from what resonates with those facing a diagnosis. Carol also explores the consequences of unfiltered language on social media and her efforts to promote more thoughtful, patient-centered communication both within and beyond the healthcare community. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. David Braun and Toni Choueiri join to discuss a groundbreaking Nature study on a personalized neoantigen vaccine for adjuvant renal cell carcinoma. They explore the inspiration behind the trial, how the vaccine was developed and administered, and its safety profile. The conversation also covers patient outcomes after 3-4 years, including immune responses and disease recurrence, as well as the rapid enrollment of this innovative study and what it means for the future of kidney cancer treatment. Read the publication in Nature. https://www.nature.com/articles/s41586-024-08507-5 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Jay Giri, Associate Professor of Cardiovascular Medicine at the Hospital of the University of Pennsylvania, joins the show to break down the recent NIH funding cuts and their impact on the medical research ecosystem. Together, he and Chadi explore the distinction between direct and indirect funding, the federal government's decision to reduce direct research funding to 15%, and how this shift affects researchers, institutions, and scientific progress. With growing concerns across the medical community and social media, they consider whether the backlash is justified and what the future holds for federally funded research. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Mohammad Jahanzeb, a renowned oncologist specializing in lung and breast cancer who opened his own virtual second opinion clinic, joins the podcast to explore the growing need for second opinion clinics and the challenges patients face in accessing them, from financial barriers to lingering stigmas. He delves into how often second opinions lead to changes in patient management, which disease settings benefit most, and how virtual second opinion models provide expert guidance while overcoming traditional obstacles. Additionally, Dr. Jahanzeb shares his serendipitous, “Forrest Gump-like” career path, the vital role of mentorship in shaping careers, and his philosophy on avoiding “professional stagnation.” Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Returning to the show, Drs. Vincent Rajkumar and Aaron Goodman engage in a dynamic debate over the evolving landscape of smoldering multiple myeloma, focusing on the highly anticipated study recently co-authored by Dr. Rajkumar and published in The New England Journal of Medicine after being presented at ASH 2024. They dissect the study's findings, which highlight the impact of early intervention with daratumumab in delaying disease progression for patients classified as high-risk. The discussion explores the nuances of smoldering myeloma classification, the controversy surrounding risk stratification, and the historical context of prior studies that failed to change clinical practice. With their expert insights, Drs. Rajkumar and Goodman break down the implications of this research, questioning whether it truly shifts the standard of care and what it means for future treatment approaches. View the NEJM publication. https://www.nejm.org/doi/abs/10.1056/NEJMoa2409029 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Sakhr (Sam) Youness, a Syrian entrepreneur and engineer, provides a comprehensive primer on artificial intelligence (AI), tracing its origins from WWII-era innovations to the breakthroughs of the 1990s that shaped modern AI capabilities. He demystifies key concepts like machine learning, large language models, and the role of labeled data in training AI systems, offering insights into how AI interprets and processes human language. Dr. Youness also examines the rise of generative AI, the development of ChatGPT, and the ethical concerns surrounding AI's proper use. Looking ahead, he discusses the next frontier—artificial general intelligence—and its implications for society, addressing the pressing question of whether AI and robotics will replace human workers. Finally, he explores AI's evolving role in healthcare, weighing its potential to revolutionize medical advancements against the risks of misuse. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Amy Abernethy and Brad Hirsch, co-founders of Highlander Health, delve into their mission to transform healthcare through innovative, data-driven strategies. They discuss their firm's unique approach to investing in companies and technologies that advance personalized care, the creation of the Evidence Accelerator to streamline high-quality real-world data, and their efforts to solve critical challenges in building faster, more reliable demonstration projects. Furthermore, they share how they ensure credibility and quality in real-world evidence, and their vision for reshaping the future of medical innovation. Learn more about Highlander Health. https://www.highlanderhealth.com/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Creed McKinnon, Co-Founder and Chief Growth Officer of VersaWare, to explore how this cutting-edge startup is redefining the intersection of technology and nutrition. VersaWare's AI-powered platform integrates voice assistants and real-time chatbot support from expert nutritionists to simplify meal building, enhance recipe discovery, and streamline pantry management. Creed shares insights into the challenges of developing a solution for users who often abandon traditional nutrition tracking apps, the innovative revenue streams behind the brand—including a consumer-friendly app—and the company's ambitious vision for the next 6 months as it seeks to empower individuals with smarter, more personalized approaches to health and nutrition. Learn more about VersaWare. https://versaware.io/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Andrew Foy, a cardiologist at Penn State Health, returns to the show to unpack the findings of his JAMA publication exploring industry payments in medicine and their influence on clinical practice. He examines how financial relationships with the industry may shape guideline recommendations, alter quality-of-care metrics, and contribute to potentially inappropriate prescribing practices, particularly in cases of expanded indications. Together, Chadi and Dr. Foy consider critical questions about whether medical societies should face the same scrutiny as individual physicians and whether backlash against industry involvement in healthcare is disproportionate compared to other sectors. Read the JAMA research letter on COIs. https://jamanetwork.com/journals/jama/fullarticle/2816900#google_vignette Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Lecia Sequist, an expert in lung cancer and early detection, and Dr. Jeff Yang, a renowned thoracic surgeon, join Chadi to unravel the complexities of early lung cancer detection. Together, they explore the nuances of lung cancer screening, including the challenges of overdiagnosis and managing false-negative and false-positive results. The discussion delves into cutting-edge advancements like multi-cancer early detection tests, current patient screening eligibility criteria, and the critical factors contributing to low screening rates, such as accessibility barriers. They end on a note to raise awareness about the importance of lung cancer screening, emphasizing its safety, simplicity, and potential to save lives. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Maz Jobrani, star standup comedian and actor, joins the show to share his career journey and his beginning as an immigrant turned comedian and celebrity. Maz shares his sister's journey when diagnosed with breast cancer at a very young age. He opens up with details on challenges of being one of her caregivers and how he balanced comedy with tragedy. His sister catalogued her journey in a documentary available on Amazon Prime, titled "Everything Must Change," that is a must-watch. Maz and Chadi celebrate his sister's life and highlight how "The Cancer Journey" addresses all elements pertaining to the unfortunate journey patients and families must undertake. Find out more about Maz Jobrani. https://www.mazjobrani.com/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Dr. Matt Davids, Director of Clinical Research in the Division of Lymphoma at Dana-Farber Cancer Institute, to unpack the latest breakthroughs in leukemia and chronic lymphocytic leukemia (CLL) from the ASH annual meeting. A pioneer in CLL treatment, Dr. Davids recounts the development of venetoclax, a transformative therapy he helped bring to clinical use over a decade ago, setting the stage for discussions on emerging updates. Together, they explore advancements in BTK inhibitors across three distinct classes, the potential of novel targeted therapies, innovative combination regimens, and the shifting paradigms in treating blood cancers, including a nod to the latest clinical trials of high potential. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

As the holidays approach, questions about maintaining nutrition, wellness, and a healthy lifestyle take center stage. Australian nutrition icons Kim Morrison and Cyndi O'Meara join Chadi to explore vitalistic principles that emphasize natural health approaches without relying on medication. They dive into how the holiday season amplifies mental health and nutritional struggles and share actionable strategies to tackle these challenges beyond mere willpower. With an anthropological lens, they break down how understanding your unique body can guide you to maintain a healthy weight, improve overall health, and develop lasting habits. The conversation also provides practical tips for identifying high-quality ingredients and making mindful food choices that support your wellness goals. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Leading into the ASH Annual Meeting, Dr. Kami Maddocks, professor in the Division of Hematology at The Ohio State University and medical director of infusion services at The James Comprehensive Cancer Center, provides an in-depth analysis of advancements in non-Hodgkin lymphoma care, with a focus on aggressive B-cell lymphoma. She explores the evolving roles of immunotherapies like CAR-T cells and bispecific antibodies in high-risk patient populations, discusses the impact of cell-of-origin testing on frontline treatment decisions, and evaluates the latest data guiding choices between R-CHOP, transplant, and CAR-T therapy after first relapse. Dr. Maddocks also highlights the promise of BTK inhibitors and maintenance approaches in transforming patient outcomes, offering insights into the future of lymphoma treatment. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Vivek Subbiah returns for another edition of Vivek's Takes, sharing his insights on key updates from ESMO Congress 2024, including breakthroughs in neuroendocrine tumors, gastric cancer, and non-small cell lung cancer. He also delves into the highlights of his AACR debate on integrating early cancer detection with AI, arguing for the transformative potential of humans with AI versus the readiness of AI today. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi welcomes Dr. Andrea Apolo, an internationally recognized leader in bladder cancer research from the National Cancer Institute. Dr. Apolo shares her expertise on recent advancements in urothelial cancer therapy, including key breakthroughs in checkpoint inhibition that have marked a significant turning point in treatment. The conversation delves into optimal sequencing and combination strategies for checkpoint inhibitors, contrasts in treatment approaches between early-stage and late-stage disease, and the evolving landscape of bladder-sparing options. Dr. Apolo also provides an in-depth look at the comprehensive process of designing, executing, and publishing impactful clinical research, highlighted by her latest publication in The New England Journal of Medicine. Read more about her NEJM trial. https://www.nejm.org/doi/abs/10.1056/NEJMoa2401726 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Joe Mikhael, Chief Medical Officer of the International Myeloma Foundation (IMF) and Professor at TGen, takes us beyond his medical career to explore the personal experiences that have shaped his journey in oncology. Dr. Mikhael discusses the IMF's targeted strategies for reducing health disparities among diverse ethnic and racial groups affected by myeloma, shedding light on specific initiatives aimed at improving access and outcomes. He also dives into his role in medical education, where he mentors the next generation of oncologists through innovative fellowship programs, advancing research, and fostering a more inclusive approach to cancer care. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Tom Beer, Chief Medical Officer of the Multi-Cancer Early Detection (MCED) program at Exact Sciences, delves into the groundbreaking science behind MCED tests, which use advanced biomarkers for early detection of multiple cancer types. He explains who may be eligible for these tests, how to interpret results to avoid unnecessary intervention from over-detection, and the varying sensitivity levels of MCED tests across different cancers. Additionally, Tom shares insights into the Falcon trial – a major real-world study assessing a MCED test clinical performance and potential impact on early cancer detection and patient outcomes. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this special episode, Chadi gives up the microphone to guest host Kelly Ryerson, who takes over the show asking questions about Chadi's new book "The Cancer Journey." What inspired the book writing? What methods are used? Who is the target audience? What did the author learn? And what did he aim to achieve? Written for everyone who wants to learn more about cancer, this discussion highlights behind-the-scenes information on Chadi's latest achievement. View more and order “The Cancer Journey.” chadinabhan.com/the-cancer-journey/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Jon Chait never thought he would get cancer, but one day he found he had it. As he navigates his journey alongside his caregiver and wife Heather, he shares with Chadi the good and the bad, the ups and downs, and what he encounters in a broken, complex healthcare system. A fitting episode as Chadi launches his book "The Cancer Journey." It is a must listen to anyone navigating the system. Is it truly patient-centric as advertised? You be the judge. View more and order “The Cancer Journey.” https://chadinabhan.com/the-cancer-journey/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Kathy Giusti, founder of the Multiple Myeloma Research Foundation (MMRF) and a two-time cancer survivor, opens up about her first diagnosis and the life-changing conversation with her primary care doctor. She reflects on the overwhelming "age of information," which often leads patients to more questions than answers, and shares her strategies for dealing with the loss of control that comes with a cancer diagnosis. Kathy also talks about the importance of identifying what truly matters, placing personal priorities in plain sight as daily reminders. She delves into the potential next breakthrough in multiple myeloma research, her success in engaging patients in MMRF's direction, and offers heartfelt advice for families on when and how to tell children about a cancer diagnosis, as well as other important points through the cancer journey, drawing from her own deeply personal experiences. Read more about the Kathy Giusti story. https://www.statnews.com/2024/09/03/multiple-myeloma-kathy-guisti-fatal-to-fearless-patient-advocate-research-fundraiser/ Find out more about Kathy's book “Fatal to Fearless.” https://www.kathygiusti.com/book Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Joe Lennerz, Chief Scientific Officer of BostonGene and a pathologist by training, joins Chadi to break down next-generation sequencing (NGS) in simple terms, discussing why some patients undergo NGS while others do not, along with its advantages and limitations. He also explores the impact of NGS on treatment pathways, the practicality of minimal residual disease (MRD) detection, liquid biopsy, and circulating tumor DNA (ctDNA), and whether immediate action should be taken after MRD detection. Additionally, Dr. Lennerz examines multi-cancer early detection technologies, who should be tested, and the future need for regulatory oversight in this rapidly advancing field. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Sanjay Patel of Weill Cornell and Dr. Greg Goldgof of Memorial Sloan Kettering dive into the transformative role of AI in modern pathology. They discuss how large language models are enhancing diagnostic workflows, expediting report synthesis, and shaping the future of patient care. The conversation also touches on the complex training required to ready AI systems for clinical use, the areas of pathology most impacted by AI today, and how this technology is being integrated into the education of future pathologists. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

David Canes, CEO of WellPrept and a Boston-based urologist, joins the show to share the story behind his innovative platform designed to reduce physician burnout. He explains how WellPrept empowers doctors to streamline patient education by organizing and delivering tailored materials before the first visit, allowing for more personalized and efficient consultations. David also touches on his entrepreneurial journey, the platform's future expansion beyond urology, and the broader impact WellPrept could have across all medical specialties. Find out more about WellPrept. https://wellprept.com/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Graduating fellows Jennifer Marks and Megan Melody join the show to discuss the challenges of navigating the job search during fellowship. They share insights on when to start looking for positions, the importance of networking through mentors and conferences, and how to handle geographic limitations in the job market. The conversation also covers key interview strategies, tips for compensation negotiations, and what to do when asked to present during an interview—especially when things don't go as planned. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Yelak Biru, President and CEO of the International Myeloma Foundation (IMF), joins the show to share his remarkable personal and professional journey. After immigrating to the US from Ethiopia, Yelak was diagnosed with multiple myeloma at the age of 26, setting him on an extraordinary path as both a survivor and a passionate advocate for myeloma patients. He discusses pivotal moments in his treatment, including seeking second opinions, utilizing groundbreaking therapies like CAR-T, and his ongoing decision to reject a transplant. Now leading the world's first and largest nonprofit dedicated to improving the lives of those impacted by multiple myeloma, Yelak shares his vision for expanding IMF's global outreach, advancing research, and empowering patients and caregivers worldwide. Learn more about the IMF. https://www.myeloma.org/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Anish Koka, a cardiologist at Jefferson Health, returns to the show for the first time since the inaugural episode in October 2020. With a sharp focus on healthcare policy, he delves into the impact of the Affordable Care Act on his practice, critiques the influence of political biases in academia, and shares his bold ideas for making healthcare insurance accessible and affordable. Dr. Koka also offers insights on prior authorization alternatives, the Inflation Reduction Act, 340B, and much more in this thought-provoking and, at times, contentious discussion. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Ziad Bakouny, MD, MSc, and Nazli Dizman, MD, return to the show to discuss the progress made for International Medical Graduates (IMGs) within the American Society of Clinical Oncology (ASCO). Building on their previous conversation, they explore the origins of their initiatives at ASCO 2022, the goals for integrating IMGs into successful medical careers in the US, and the significant challenges posed by Visa constraints. Together, they expand on the unique hurdles faced by IMGs in oncology, how these compare across specialties, and the ongoing efforts to support IMGs. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Russell Gong, President and CEO of Cabinet Health, and Eric Lessard, Vice President of Pharmacy, to explore their mission to revolutionize the healthcare industry with sustainable practices. They discuss the inspiration behind Cabinet Health, the significance of reducing plastic waste with their eco-friendly refillable medicine system, the startup's success metrics, their customer engagement strategies, and the unique features of their packaging. Additionally, they share insights from their transformative experience on Shark Tank and how it helped propel their vision for a greener healthcare future. Find out more about Cabinet Health. https://cabinethealth.com/ Watch the Cabinet Health pitch on Shark Tank. https://www.youtube.com/watch?v=Cf4n8UCp4r4 Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Dr. Ishwaria Subbiah, Executive Director for Cancer Care Equity and Professional Wellness at the Sarah Cannon Research Institute, joins Chadi to delve into the complexities of professional wellbeing and burnout in the healthcare field. She explores the prevalence of burnout, the concept of "learned helplessness," and effective strategies for improving organizational wellness and resilience among healthcare professionals. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Christian Rolfo, MD, PhD, of Mount Sinai Medical Center, explores the science and clinical applications of liquid biopsies, including circulating tumor DNA. With Chadi, he explains how this cutting-edge approach compares to traditional tissue samples in terms of concordance, sensitivity, and specificity, and expands on the methods used to distinguish signal from noise in liquid biopsy results. Dr. Rolfo discusses which thoracic patients should receive liquid biopsies and the optimal timing within their care journey. He also covers the clinical decisions informed by liquid biopsy data, such as advising on adjuvant therapy, and debates the potential role of liquid biopsies in screening and early detection for healthy individuals. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

It's July/August and this is the time when residents and fellows start their new chapter of their lives. In this special episode, Chadi tackles the fellowship application process using the "hematology/oncology" fellowship as an example, while keeping the conversation broad to most other fellowships in other disciplines. To better understand the process and the issues, he has invited a fellowship program director and a fellow applicant. Marc Braunstein, fellowship program director at NYU Langone Health, and Megan Melody, a fellow at Northwestern, discuss the intricacies of applying for internal medicine fellowships. They delve into what makes a strong application, the various types of fellowship programs, and the perspectives of both applicants and program directors in the matching process, including how to write a compelling personal statement, secure strong references, and choose which programs to visit, as well as so much more. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by Drs. Rana McKay and Petros Grivas to discuss the latest genitourinary oncology research updates from the 2024 ASCO Annual Meeting, covering topics such as the prognostic ability of KIM-1 in kidney cancer, patient-reported outcomes from enfortumab vedotin/pembrolizumab treatment, and the final overall survival update from the JAVELIN Renal 101 trial. The conversation also delves into studies on IO/TKI biomarkers, adaptive trials with ctDNA, and the latest findings from trials like KEYNOTE-426, CLEAR, PSMAfore, and SURE-01. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this exclusive interview, Chadi welcomes Dr. Patrick Soon-Shiong, a Chinese immigrant who grew up under apartheid in South Africa and rose to become one of the world's most successful physician executives. Now the CEO of ImmunityBio, Dr. Soon-Shiong opens up about his remarkable journey. He shares what inspired him to pursue medicine, his entrepreneurial ventures, his move to the United States, and the story of his first investment. He discusses creating the groundbreaking chemotherapy drug Abraxane, which led to the formation of Abraxis, later acquired by Celgene, now part of BMS. He also expounds on his most recent FDA-approved drug, Anktiva, for bladder cancer. With complete candidness, Dr. Soon-Shiong reflects on his challenging upbringing, the discrimination he faced, and how he overcame these obstacles to achieve great success. He and Chadi explore life lessons, leadership styles, and a range of topics including Kobe Bryant, Gavin Newsom, COVID-19, the first pancreatic transplant, the acquisition of the Los Angeles Times, and his public feud with his brother. This 2024 podcast episode offers an unparalleled glimpse into the life of a highly public and inspiring figure and is one you'll want to listen to more than once and share with everyone you know. Read more about Dr. Soon-Shiong. https://immunitybio.com/our-founder/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. Balazs Halmos and Lecia Sequist delve into the groundbreaking updates from the 2024 ASCO Annual Meeting. With Chadi, they reveal game-changing insights on EGFR-mutated lung cancer from the LAURA trial, small-cell lung cancer upgrades from the ADRIATIC trial, important revelations in ALK mutation research, innovative combination therapies, ctDNA results from the ADAURA trial, and conclude with the relevance of the KRYSTAL-12 study. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Vivek Subbiah, MD, Chief of Early-Phase Drug Development at Sarah Cannon Research Institute, kicks off his new series on Healthcare Unfiltered, “VIVEK'S TAKES,” in which he will provide his expert feedback on the importance and lasting effects of research presented at the top medical conferences in the world. In response to the 2024 ASCO Annual Meeting, Dr. Subbiah shares the themes he sees being developed in multiple cancer subspecialties, including breast, lung, and pancreatic, as well as the research-driven benefits of receiving care on clinical trials and early palliative care via telemedicine. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by Kate Dilligan, Founder and CEO of Cooler Heads Care, the manufacturer of a portable scalp cooling system authorized for adults 21 and older undergoing chemotherapy for a solid tumor. Kate shares her personal journey from being diagnosed with breast cancer to becoming an entrepreneur driven by a mission to help women undergoing chemotherapy mitigate the side effect of hair loss. Kate discusses the science behind the scalp cooling system and its effectiveness in preserving hair. She also delves into her innovative business model that supports infusion centers in remaining profitable, her journey in securing investors, and the future goals of Cooler Heads Care. Find out more about Cooler Heads. https://coolerheads.com/ Read Kate's profile in Forbes. https://www.forbes.com/sites/maggiemcgrath/2022/12/28/meet-the-entrepreneur-helping-women-undergoing-chemo-keep-their-hair/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with David Krissman, a journalist and filmmaker whose passionate advocacy for kidney transplant and dialysis patients led him to create the groundbreaking podcast documentary series, "The Great Social Experiment." Krissman shares the harrowing personal story that inspired his film script, website, and podcast, exposing the stark financial incentives driving the U.S. healthcare system's approach to kidney transplantation and dialysis. Designed specifically for patients, his work offers crucial insights to help them navigate the often perilous landscape. The conversation broadens to address the challenges of routine clinical care, contrasting the U.S. system with those of other countries, providing a comprehensive look at the ongoing struggle for better, more equitable healthcare. Find out more about The Great Social Experiment. https://www.thegreatsocialexperiment.net/ Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Ronald Chapman, LLM, Shareholder and Chairperson of White Collar Defense & Government Investigations at Chapman Law Group, delves into the intricate intersections of law and daily life, highlighting the subspecialized nature of healthcare law and his primary areas of focus within this field. He offers insights into his strategic choices between judge and jury trials, providing a nuanced perspective on opioid prescriptions, and delineates the fine line between lawful and unlawful practices. Ronald also unpacks the complex legal nuances involved in cases of unlawful opioid prescriptions, offering listeners a deep dive into the legal challenges and considerations in these critical issues. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA