Podcasts about tgen

In this episode of TGen Talks, we spotlight the Ivy Neurological Sciences Internship Program at TGen. This year-long program bridges the gap between undergraduate studies and medical school, providing aspiring physicians with direct laboratory experience. Interns actively participate in ongoing research, often leading independent projects. Joining our podcast is Ivy Intern, Megan Locklear, who's completing a year-long internship working in the glioblastoma lab before entering medical school. Her work exemplifies how TGen empowers the next generation of medical researchers. Join us as we discuss her experiences and the impact of this unique internship. The year of lab work has taught Megan more about what type of medical field she might pursue, the importance of biomedical research when dealing face-to-face with patients and their families and why stepping outside your comfort zone can bring about the best possible learning experiences.

This month on TGen Talks, we get an insider's perspective on how today's biomedical research translates into tomorrow's treatments. We sit down with Stephanie Pond, Ph.D., Vice President of Emerging Opportunities at TGen. We'll Learn about the crucial role of TGen's START and EDP programs – the Scientific Technology Assessment Research Team and Enterprise Directed Programs – in accelerating this process. Dr. Pond explains how her team works to identify gaps in current research tools, partner with biotechnology companies to develop new technologies, and help commercialize TGen's research discoveries. She highlights how advances in multiomics, single-cell sequencing, and spatial technologies are transforming biomedical research and enabling new diagnostic tests and treatments. Dr. Pond also discusses TGen's Enterprise Directed Programs, which focuses on taking research discoveries and developing scalable clinical tests and products. Join us to hear Dr. Pond's passion for technology and science and her dedication to bringing personalized medicine to life, faster.

Beer, Manuela www.deutschlandfunk.de, Kultur heute

Pulmonary Fibrosis. A debilitating disease that restricts a person's lung capacity, controllable with drug therapies, but it's only “cure” is a double lung transplant. Researchers at TGen have released the results of a study that investigated the disease on a cellular level. Using advanced spatial transcriptomics, they identified hidden disease markers in seemingly healthy lung tissue—offering hope for earlier, more personalized treatments. Targeting these early disruptions could improve lung function and outcomes. With current PF treatments only slowing decline, this discovery, published in Nature Genetics, marks a step toward preventing irreversible damage. In this episode of TGen Talks, Nicholas Banovich, Ph.D., discusses the Nature Genetics finding and the new spatial map of gene expression in lung cells. Instead of blending tissue together and analyzing it, scientists can now examine individual cells and pinpoint where molecular changes happen. We'll break down what this means, how it's done, and why it could change the way we study lung disease.

In this episode of TGen Talks, which celebrates Women's History Month (March), we'll explore how women in science have shaped the world around us, and how their stories continue to inspire future generations of young women to become researchers, leaders, and trailblazers who continue to break barriers. Joining the podcast this month is Bethany Davis, Ph.D., an enrolled member of the Turtle Mountain Band of Chippewa Indians and a Research Assistant Professor in TGen's Clinical Genomics and Therapeutics Division. Davis specializes in studying the effects of environmental toxins, like heavy metals, and other conditions that affect the kidneys. She's particularly focused on understanding the molecular characteristics behind kidney cancer in Native American communities. Beyond her research, however, Dr. Davis shares her personal journey into science. As a woman in a field traditionally dominated by men, she'll highlight some of the unsung pioneers whose work laid the foundation for modern science, reflect on her personal career path, the challenges she's faced, and her vision for the future of cancer genomics in Native American health. Join us for an inspiring conversation that illuminates the power of women in science and their impact on advancing health and innovation.

What if the cure for diseases like Alzheimer's or cancer lay hidden inside the immune systems of llamas, cows, or even sharks? 
    On this episode of TGen Talks, TGen's newest faculty member, Dr. John Fryer, introduces us to the world of nanotherapeutics—a new class of biologics derived from the unique immune systems of animals like camels and sharks. These ultra-small molecules, known as “nanobodies,” are revolutionizing the way we think about treating diseases like Alzheimer's, cancer, and even sepsis.
    Dr. Fryer explains how these tiny molecules—about 10 times smaller than traditional monoclonal antibodies—can target tough-to-reach areas like the brain, offering new hope for conditions once thought impossible to treat. He dives into his team's work on neurodegenerative diseases, sepsis, and cancer, and shares how the collaboration between TGen and City of Hope is accelerating the development of these next-generation therapies.
    What's even more fascinating? How creativity and curiosity drive scientific discovery, with Dr. Fryer's lab exploring everything from nano and pico bodies to the science behind brain tumors. Tune in to learn about the science, the passion, and the unexpected inspiration that drives this groundbreaking research.

Scientists have long known that farm chemicals can be harmful to human health. Many lawn and garden products used by consumers carry warnings, so that users can protect themselves  when applying herbicides in their own yards.  
But which chemicals are the most dangerous? And how much exposure is too much to be considered safe? A new study from TGEN and Arizona State University is shedding light on glyphosate, a common chemical in many herbicides, and its findings indicate that not only does glyphosate cross the blood brain barrier, but its damaging effects on the brain can remain long after the exposure.  Patrick Pirrotte, Ph.D., and colleagues at Arizona State University have identified an association between glyphosate exposure and symptoms of neuroinflammation, as well as accelerated Alzheimer's disease-like pathology. The study tracks both the presence and impact of glyphosate's byproducts in the brain long after exposure ends, showing an array of persistent, damaging effects on brain health.  Listen as Dr. Pirrotte discusses the methods used in the research and how the pervasive use of such chemicals means that most Americans, even those who have no exposure to farms or the application of such herbicides have traces of the harmful compounds in their bodies.

Dr. Joe Mikhael, Chief Medical Officer of the International Myeloma Foundation (IMF) and Professor at TGen, takes us beyond his medical career to explore the personal experiences that have shaped his journey in oncology. Dr. Mikhael discusses the IMF's targeted strategies for reducing health disparities among diverse ethnic and racial groups affected by myeloma, shedding light on specific initiatives aimed at improving access and outcomes. He also dives into his role in medical education, where he mentors the next generation of oncologists through innovative fellowship programs, advancing research, and fostering a more inclusive approach to cancer care. Check out Chadi's website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

On this month's TGen Talks, our host sits down with Leigh Nicholson, Ph.D., who was recently named a research assistant professor in TGen's Early Detection and Prevention Division. Nicholson studies neurological diseases of all kinds — from the rarest to the very common — including a childhood disorder called Okur-Chung neurodevelopmental syndrome, or OCNDS for short, and Alzheimer's disease, which affects nearly 7 million Americans. The podcast covers her path to a career in science, her day-to-day research, and why she thinks mentoring young scientists and improving scientific literacy is so important. All this and more, in just under 15 minutes.

When we think of October many of us think fall, Halloween, maybe sweater weather if it ever decides to cool down! But to thousands of women, and men, out there, October is Breast Cancer Awareness Month. According to the National Breast Cancer Foundation 1 in 8 women in the United States will be diagnosed with breast cancer in her lifetime. In 2024, over 300,000 women & men will be diagnosed with invasive breast cancer. Chances are, you know at least one person who has been personally affected by breast cancer. But there is hope. When caught in its earliest, localized stages, the 5-year relative survival rate is 99%. Advances in early detection and treatment methods have significantly increased breast cancer survival rates in recent years, and there are currently over 4 million breast cancer survivors in the United States. That's why today I'm proud to talk about how TGen and City Of Hope have teamed up to help raise funds for cancer research for Women. We're going to talk with Tgen Runway for Research Chairwomen Molly Stockley & Justine Hurry.   Calendar of Events TGEN Runway for Research Get your tickets now for the October 18th event at Neiman Marcus Fashion Square. It's happening from 9-11am and is sure to be a great way to start your morning. If you haven't already, you will know someone that is affected by cancer. So start making a difference now by donating and attending this event.    The Polo PartyIn its 13th year The Polo Party at WestWorld is sure to be a great day! If this episode didn't convince you to go, I don't know what will. Plenty of fun throughout the day so come out and enjoy with friends and family.   Barrett- Jackson Happening this week,  October 10-13. They are doing a fall show this year so get your tickets now. Three days of fun including cars, food competitions and a car collectors show. SUBSCRIBE on your Favorite podcast listening app. Find us on IG & FB at Scottsdale Vibes Podcast or check us out on scottsdale vibes dot media. And don't forget that we are now the proud owners of Scottsdale City Lifestyle magazine where you can read about even more of your favorite community.   

When we think of October many of us think fall, Halloween, maybe sweater weather if it ever decides to cool down! But to thousands of women, and men, out there, October is Breast Cancer Awareness Month. According to the National Breast Cancer Foundation 1 in 8 women in the United States will be diagnosed with breast cancer in her lifetime. In 2024, over 300,000 women & men will be diagnosed with invasive breast cancer. Chances are, you know at least one person who has been personally affected by breast cancer. But there is hope. When caught in its earliest, localized stages, the 5-year relative survival rate is 99%. Advances in early detection and treatment methods have significantly increased breast cancer survival rates in recent years, and there are currently over 4 million breast cancer survivors in the United States. That's why today I'm proud to talk about how TGen and City Of Hope have teamed up to help raise funds for cancer research for Women. We're going to talk with Tgen Runway for Research Chairwomen Molly Stockley & Justine Hurry.   Calendar of Events TGEN Runway for Research Get your tickets now for the October 18th event at Neiman Marcus Fashion Square. It's happening from 9-11am and is sure to be a great way to start your morning. If you haven't already, you will know someone that is affected by cancer. So start making a difference now by donating and attending this event.    The Polo PartyIn its 13th year The Polo Party at WestWorld is sure to be a great day! If this episode didn't convince you to go, I don't know what will. Plenty of fun throughout the day so come out and enjoy with friends and family.   Barrett- Jackson Happening this week,  October 10-13. They are doing a fall show this year so get your tickets now. Three days of fun including cars, food competitions and a car collectors show. SUBSCRIBE on your Favorite podcast listening app. Find us on IG & FB at Scottsdale Vibes Podcast or check us out on scottsdale vibes dot media. And don't forget that we are now the proud owners of Scottsdale City Lifestyle magazine where you can read about even more of your favorite community.   

Every September, the scientific community recognizes postdoctoral researchers during Postdoc Appreciation Week. Postdocs bring new ideas and deep expertise as they tackle complex questions and expand knowledge through experiments.     In this month's episode of TGen Talks, Aya Kamzina, Ph.D., one of TGen's 11 postdoctoral researchers, shares her journey to becoming a postdoc and her experiences at TGen.     Dr. Kamzina's educational path began in Kazakhstan and differs from many of her peers. She discusses her work with organoids and microglia in Dr. Huentelman's neurogenomics lab, as well as her diverse background in biochemical engineering and molecular biology. Dr. Kamzina also explains why she finds TGen's translational research meaningful and how it aligns with her goals in shaping the future of science.

Seit Beginn der 1990er-Jahre entsteht unter der Ägide des Dichters Anton G. Leitner und mit wechselnden Co-Herausgebern die Zeitschrift „Das Gedicht“. Sie erscheint einmal im Jahr. Unter wechselnden Überschriften versammelt sie Lyrik bekannter und weniger bekannter Dichter und Dichterinnen. Nun ist unter dem Titel „Laut & Leise“ die 31. Ausgabe der Zeitschrift erschienen. Rezension von Beate Tröger

Seit Beginn der 1990er-Jahre entsteht unter der Ägide des Dichters Anton G. Leitner und mit wechselnden Co-Herausgebern die Zeitschrift „Das Gedicht“. Sie erscheint einmal im Jahr. Unter wechselnden Überschriften versammelt sie Lyrik bekannter und weniger bekannter Dichter und Dichterinnen. Nun ist unter dem Titel „Laut & Leise“ die 31. Ausgabe der Zeitschrift erschienen. Rezension von Beate Tröger

Scientists at TGen have released the results of a more than decade-long study into multiple myeloma. Looking at more than 1100 patients from four different countries, scientists identified new genetic subtypes of the disease, providing insights that could transform how we approach treatment (see related story above). Listen as Jonathan Keats, Ph.D., the study's senior author discusses the findings, their impact on personalized medicine, and how TGen's advanced genomic sequencing is paving the way for more effective and individualized care. In particular, the study has identified a high-risk subgroup of patients with a distressingly short median survival, highlighting the urgent need for tailored therapies and innovative clinical trials.

Aging. It's something we'd all like to do better. Americans spend an estimated $5 Billion on anti-aging products every year. But at TGen and City of Hope, scientists like TGen distinguished professor Nicholas Schork, Ph.D., are working to unlock the secrets to not just better ‘aging,' but disease prevention alongside longevity, and are making promising progress toward medications and methods that will be tailored to each specific person, rather than those that promise longer healthier lives for all. In this episode of TGen Talks, our host Karie Dozer sits down with Schork to discuss the groundbreaking search for substances that can slow down aging. Imagine a daily pill that not only extends your lifespan but also your health span, delaying age-related diseases like heart disease, diabetes, and cancer. Schork, with his extensive background in quantitative genetics and translational biomedical science, explains the exciting potential of longevity and health promoting interventions, termed ‘geroprotectors,' and the race to develop them. We'll explore the challenges and excitement of developing anti-aging interventions, the race to find effective solutions, and the potential of personalized treatments through “N-of-1” trials. Join us as we delve into the future of aging research and the hope it brings for healthier, longer lives.

On this month's TGen Talks, David Engelthaler, Ph.D., professor and director of TGen's Pathogen and Microbiome Division, discusses the recent surge of bird flu, also known as H5N1. 
H5N1 has been in the news a lot lately, but what does it all mean? Engelthaler breaks down the science and talks about the effects this particular strain might have on humans. He also explains what constitutes an outbreak, how they fade over time, and why they start anew. 
Bird flu, like other influenza viruses, changes and mutates over time, and the H5N1 strain is particularly concerning. Although it is currently a low risk for human outbreak (there are only 3 known cases in the U.S. thus far), its impact on other animals, especially poultry and cattle, caught the attention of the CDC, USDA and other groups that monitor such outbreaks. 
Engelthaler notes that outbreaks are often first noticed by wildlife managers or at zoos, where bird die-offs prompt testing for influenza. Over the past two years, the current bird flu strain has spread significantly by wild birds across North America and the rest of the world. 
The good news: In Arizona, only one mammal, an Abert's tree squirrel, has tested positive for H5N1 to date. TGen researchers are working with local wildlife and health officials to monitor the situation.

This month, TGen Talks explores polygenic risk scores with Dr. David Duggan, an associate professor in the Quantitative Medicine and Systems Biology Division at TGen. A polygenic risk score is a number that indicates the combined effect of many genetic variants on a person's risk of developing a certain trait or disease. Each genetic variant adds a small amount to the overall risk. When these small effects are added together, they help predict the likelihood of developing the trait or disease.
     Think of the human genome as a deck of cards, where each card represents a different genetic variant. The value of each card represents the risk contribution of that variant. For example, an Ace might represent a high-risk variant (4 points), while a 2 might represent a low-risk variant (1 point). Let's assume all contributions are positive for simplicity, although in reality, some variants might reduce risk.
    Imagine drawing 10 cards from the deck randomly. These 10 cards represent the genetic variants you inherited from your parents. Each card has a point value (risk contribution). Adding up the points of the 10 cards gives you your polygenic risk score. This score indicates your genetic predisposition to the trait or disease. You can then compare this score against population averages or thresholds to determine if you are at higher or lower risk for the trait or disease.
     In this analogy, each card represents a genetic variant, and its point value represents its contribution to your overall genetic risk for a specific trait or disease. The polygenic risk score is the sum of these contributions, much like summing the values of drawn cards to get a total score. This information can help you and your doctor make informed health decisions, such as focusing on preventive measures. Dr. Duggan notes that lifestyle factors also play a significant role in disease risk, sometimes reducing genetic risk by up to 50%.
 Whether you're a healthcare professional, a genetics enthusiast, or just curious about the future of personalized medicine, this month's TGen Talks is worth the listen.

En un pueblo alemán, la gente queda en shock cuando se extraen los restos humanos de una persona tan mutilada que es imposible de reconocer. Cuando los arqueólogos investigan, revelan pruebas de un sacrificio humano de la Antigüedad.Un arqueólogo realiza una ascensión de 7 kilómetros hasta coronar una montaña en Argentina, cerca de un volcán activo, descubriendo restos de unos niños excepcionalmente bien preservados, tanto que parecen dormidos.

Glioblastoma. It's the most aggressive and least treatable type of brain cancer. Research into treatment has been slow, mostly because of the difficulty in accessing and treating a tumor that exists behind the blood-brain barrier.
 A new two year fellowship into Glioblastoma Multiforme, or GBM, aims to better drug therapies to fight the cancer while developing better tests to determine which drugs are working on an individual patient's tumor and which are not. 
 The fellowship, established by Shawn Lane and the Lori Lane Foundation together with Chris and Florence Spyrow, honors Lori Lane and Andrew Spyrow, whose lives were cut short by GBM.
 This month on TGen Talks, Valerie De Luca, Ph.D., the inaugural Lori Lane/Andrew Spyrow Fellow at TGen discusses her work toward improving our understanding of molecular markers associated with tumor vulnerability to specific drugs.

Don't miss The Balm In Gilead's  Multiple Myeloma Spotlight on our website!This week's guest, Dr Joseph Mikhael MD, MEd, FRCPC, FACP,  leads the M-Power project in the African American community for the International Myeloma Foundation (IMF). Dr. Mikhael is a Professor in the Applied Cancer Research and Drug Discovery Division at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope Cancer Center. He is the Chief Medical Officer of the IMF and Director of Myeloma research at the HonorHealth Research Institute. Dr Mikhael specializes clinically in plasma cell disorders, namely multiple myeloma, amyloidosis, and Waldenstrom's macroglobulinemia. He is the PI of many clinical trials, primarily in relapsed multiple myeloma, and his other clinical research interests include pharmaco-economics, communication skills, and media relations. Dr. Mikhael also serves as the Treasurer on the executive board of the American Society of Hematology. Dr Mikhael has published over 200 peer-reviewed articles in these fields, and lectures internationally on a regular basis.  He is also the chair of the Diversity, Equity and Inclusion Council at TGen.  Dr. Mikhael is heavily involved in training future researchers, and mentors junior faculty worldwide.  He also spends nearly 20% of his time in the third world developing collaborations in myeloma and finding ways to enhance access to novel treatment agents.

Auf einem nächtlichen Spaziergang erkunden wir mit Dr. Moritz Woelk die Welt der Heiligen und ihre Bedeutung für die Menschen des Mittelalters und der Frühen Neuzeit.

Cancer continues to be the second most common cause of death in the United States, with a total of nearly 2 million diagnoses every year.   In this episode of TGen Talks, recorded in front of a live studio audience, we take a look at how genomic information is leading to better and earlier diagnoses and treatments for all kinds of cancer and how the collaboration between City of Hope Cancer Center Phoenix and TGen is proving to be a mighty weapon in the fight against cancer right here in Arizona.   Joining the podcast this month are TGen President and Research Director, Dr. Jeffrey Trent, and City of Hope Cancer Center Phoenix Chief Clinical Officer, Dr. Alan Bryce.

Paul J. Luna, president and CEO of Helios Education Foundation, sits down with TGen Talks to discuss the transformational power of education, in particular, how internships help prepare students for future success. Helios Education Foundation supports postsecondary attainment for all students, especially low-income and underrepresented communities, in Arizona and Florida. Earlier this month, Helios committed funding to extend the TGen Bioscience Leadership Academy (TBLA) through 2028 (see related story). TBLA spun out of TGen's Helios Scholars Program in 2018, with a focus on supporting high-school students interested in careers in biomedical research and medicine. In addition to the Helios-funded programs at TGen, Luna discusses Helios' focus on helping students achieve educational success beyond high school and the importance of opening the programs to all students, regardless of background. And how rewarding it is to help students find a track to success, whatever that success may be. Students should allow themselves to dream big, he says. Be willing to apply, be willing to say, I want to be part of that unique cohort of talented students who are going to learn and evolve and build a network and maybe, one day, find the cure for Alzheimer's or cancer.

More than three years after the beginning of the pandemic, humans still spread COVID to one another every day, though with less severe symptoms in most cases. Scientists also know that we can spread COVID to our pets as well, because of the close relationships many of us have with our four-legged friends. While dogs CAN get COVID from humans, they don't seem to get very SICK. So, what's the big deal if we spread the virus to our pets?  Can dogs spread it back to humans or to other animals? TGen scientists are looking to answer these and other questions in a new study called the 1000 Canine (1K9) SARS-CoV-2 Surveillance Study … and they're looking for dogs to participate. Hayley Yaglom, MS, MPH, a genomic epidemiologist who leads TGen North's One Health team and the 1K9 study joins TGen Talks to discuss the study and how the information gained will help tailor guidance for public health, veterinary professionals, and people interacting with dogs in various settings.

Today, the world of biomedical science is changing how we think about disease and, certainly, how we treat it ... but did you ever wonder how discovery happens?    What does a lab look like? What type of equipment do they use? Who exactly is working inside? How many scientists and staff? And on what projects?   On this episode of TGen Talks, Kristen Kaus, Manager of TGen's Education and Outreach programs, talks TGen, specifically, what guests and visitors see and hear when they go on a tour.   While you might not learn everything modern research, you will gain an insider's knowledge of TGen.   She also talks about STEM education and the programs at TGen designed to foster a love of science and support students aiming for a career in bioscience. If that's you, a TGen tour is a great way to see science in action.

In a world filled with untapped possibilities, discovering the keys to personal and professional growth not only empowers you to fully embrace your potential but also equips you with the tools to inspire your team, enabling them to unlock their potential as well.Listen in for an insightful conversation that will leave you inspired and empowered to embrace your creative potential! Panelists:Doretha Bailey, VP of HR, Turf Masters BrandsBrady Young, Principal Coach & Consultant, Thrive Coaching and Consulting, LLCMarissa Andrada, Culture Master & Kindness Catalyst, Board Director, Krispy KremeModerated by: Derek Lundsten, President & Chief Culture Officer, LifeGuidesChapters:00:00 Introductions07:24 Being a Rebel: cultivated or innate?16:51 How have you handled recent massive shifts?23:30 Personalization over standardization27:07 The importance of grace30:05 Innovation, creativity, and mobility in HR36:43 Being a voice for the unheard41:20 What are you doing to develop yourselves?BIOS:Brady is a savvy business and HR leader who understands the levers of a business and builds people operations that support exceeding its goals. His superior skills in communication and relationship-building make it possible to gain trust rapidly so that he can get organizations to the next level of success through their people. Additionally, Brady is highly trusted and valued for his ability to coach and mentor leaders. Brady has 20 years of experience in HR at TGen, Plexus, CVS, Intel and Raytheon and has created cutting-edge HR and TA functions in a number of startups. Currently, Brady is Principal Coach and Consultant at Thrive Coaching and Consulting, LLC.Doretha Bailey, MBA is the VP of People & Culture for Turf Masters Brands.  As VP, she is responsible for providing strategic guidance and leadership to all aspects of the human resources functions and operations. She possesses 20+ years in human resources, organizational development, and leadership. Her career spans over several industries including telecommunications, defense, manufacturing, faith-base, military, pharmaceutical, franchising and now turfgrass.Marissa Andrada is a master of activating organizational hyper-growth and turnaround through the transformation and creation of dynamic, diverse and inclusive cultures. With over 25 years of experience of integrating people and leadership capability into the foundation of business strategies, she has energized brands to codify their purpose and values while accelerating company growth and industry-wide change, inspiring a movement for employee well-being and opportunity. Marissa has been the key catalyst in transforming cultures and driving performance at a multitude of consumer brands, most recently as the first chief people officer at Chipotle Mexican Grill. She is currently serving as an independent board director at Krispy Kreme, Inc. where she is also the chair of the Remuneration and Nomination Committee.Follow Brady on LI: https://www.linkedin.com/in/brady-young-hrexec/Follow Doretha on LI: https://www.linkedin.com/in/doretha-bailey/Follow Marissa on LI: https://www.linkedin.com/in/marissaandrada/

For a patient diagnosed with multiple myeloma, a type of blood cancer, there are more treatment options than ever and traditional chemotherapies that cause debilitating side effects have been all but completely replaced by immunotherapies, treatments that help a patient's own immune system better fight the disease. But in many patients, a chosen immunotherapy drug can show great promise in early treatments, yet seemingly stop working altogether as time goes by.   In a paper that was published in Nature Medicine, TGen's Dr. Jonathan Keats explains how upwards of 65% of relapsing multiple myeloma patients could be affected by mutations that impact targeted T cell treatments.   On this episode, you'll hear about a study that found how these cancer cells were mutating to evade the very drugs prescribed to fight them. The findings could help clinicians and patients choose from among a variety of T cell therapies for multiple myeloma to find treatments that best match a patient's available tumor targets.   Dr. Keats also discusses his broader work in multiple myeloma and plans for a rapid sequencing center that will place valuable genomic-informed data in the hands of treating physicians in just 48 hours.   All this and more on TGen Talks.

Intro: Warm welcome to Tony Felice, our returning special guest co-host from episode 335: Kindness in Combat. Introduction to Tammy Crawford, Executive Director of Focus on Lyme. Tammy's Personal Journey: The personal story of Tammy's daughter, Jessica, who battled Lyme disease. The emotional and medical challenges faced by Tammy in seeking proper treatment and diagnosis for Jessica. Encounter with Dr. Horowitz and the importance of finding a Lyme-literate physician. Focus On Lyme: Tammy's response to the Lyme community's struggles, including the formation of the non-profit Focus On Lyme. Collaborative efforts with past podcast guests and their significant accomplishments, including: Speaking on Capitol Hill. Organizing research conferences. Funding advancements in Lyme disease testing. Overview of Tammy's bio-repository and its purpose. The TGen Connection: The recurring appearance of TGen in Tammy's journey and their role in Lyme disease research. Specific discussions and projects with TGen. Focus on Accurate Diagnosis: Tammy's emphasis on the importance of accurate diagnosis to garner more funding and attention. The challenges and limitations of current diagnostic measures and the potential of next-gen serology. Breakthroughs & Discoveries: Collaboration with researchers and scientists in the Lyme community. Exciting advancements in Lyme disease research, including potential overlaps with cancer treatments. The complexity of Lyme disease strains and the importance of understanding the differences. Funding & Future Steps: The financial challenges and efforts to fund more research, especially diagnostic improvements. Tammy and her team are working on an FDA-cleared Lyme diagnostic tool. Conclusion & Call to Action: A look ahead for Focus On Lyme and Tammy's continued advocacy work. A request for community involvement, collaboration, and investment. How to contact and support Tammy's efforts through Focus Online.

The phrase "gut health" has become quite a buzzword in recent years, and researchers like this month's guest will tell you quite candidly that we have a lot to learn about the community of microorganisms that live INSIDE the human body. But one thing seems to be clear. The human being with a "healthy gut" is far better able to fight a cancer diagnosis than the human with poor gut health. Regardless the current standard for a healthy human microbiome, the data being compiled on this relatively new topic is vast. One TGen researcher is uniquely qualified to analyze and manage such data, and is doing so at TGen North. Dr. Greg Caporaso is a bioinformatician-- with expertise in both computer science and the human microbiome. On this episode of TGen talks, he explains how his study of this important body system started not in a pre-med class, but in the computer lab.

Most of us had a summer job when we were in high school or college, and if we were lucky, we had one that helped us make meaningful decisions about college or a career. 
  At TGen, summer interns in the Helios Scholars at TGen program work alongside researchers on projects that are much more than “just” eight weeks of full-time hours inside a lab. Many Scholars choose a field of research they will pursue for an entire career.
   On this episode of the TGen Talks, we connect with Heather Mead, Ph.D., a research assistant professor in TGen's Pathogen and Microbiome Division. A former Helios Scholar who describes the eight-week internship as life changing and encouraged her to begin a second career in research, one that has seen her come full circle as today she mentors Helios Scholars, helping them find and follow their passion … all while conducting research and coordinating projects around Tuberculosis, Valley Fever, COVID and more.

What if you could take a simple test to find out just how susceptible you are to Covid19, the Flu, or any other virus? What if you could test your exposure and immunity to EVERY virus known to mankind using a single drop of blood? The technology is here, now. And at TGen, researchers are using it to understand the human immune response and predict and track the next global outbreak. What's more, the human immune system not only protects us from viruses and pathogens, it can help prevent the onset of deadly diseases triggered by those infections. This month's podcast is an introduction to something called PepSeq (pep-seek), a breakthrough technology that allows scientists at TGen to detect infections by – and immunity to – the entire human virome.

This month, our host Karie Dozer sits down for a personal conversation with Maria Fundora, who is neither a scientist nor a clinician. She's a businesswoman from Alpharetta, Georgia, a restauranteur and founder of Purple Pansies, a nonprofit organization dedicated to raising awareness and funds for pancreatic cancer research. And like most nonprofits that support research, there's a story about how it all began, and most often in whose memory. Maria's mother passed away from pancreatic cancer in 2007, inspiring Maria to start Purple Pansies. The organization began with $3,500 raised on Mother's Day in 2008. Maria chose the name Purple Pansies because purple represents pancreatic cancer and pansies symbolize resilience. Initially, Purple Pansies held two annual events, a community gathering and a gala in Maria's restaurant. It wasn't until 2010 that Maria learned about TGen. Impressed by TGen's approach, Maria established a partnership that to date has raised millions. All this and more with Maria Fundora on TGen Talks.

Maria Fundora founded the nonprofit, Purple Pansies in 2008 following her mother's death from pancreatic cancer. She felt called to raise awareness and crucial research dollars for this chronically underfunded but deadly cancer. To date, Purple Pansies has raised over $4 Million to fund research through TGen and aid affected families. The mission of Purple Pansies is to raise funds for research, clinical trials, and early detection, and to aid families in the community who have a family member suffering from pancreatic cancer and financially can use their help. ✨A few highlights from the show: 1. Pancreatic cancer is sometimes called a “silent” disease because symptoms are rarely noticeable in its early stages. If symptoms are present, they are often vague and can be easy to ignore. 2. A few symptoms: abdominal or mid-back pain, change in stool, digestive problems such as gas and bloating, and several others. 3. Pancreatic cancer awareness month is in November. 4. Pansies are resilient flowers. The root grows strong all winter and they grow during the worst of times in the winter. Hence, Purple Pansies.  5. Don't be afraid to get a second opinion when you or a loved one are diagnosed with cancer and trying to determine the best treatment options. 6. Maria has a couple of goals that she could use your help with.  a. Expand the Purple Pansies Board. She is looking for volunteers to be on the Board and chair committees to help Purple Pansies become a national footprint. b. Develop an early detection test for pancreatic cancer.

When treating cancer patients, physicians are often faced with tough choices.  Treatment options like radiation can often come with unpleasant, for some, unbearable side-effects. Doctors walk a fine line between stopping the growth of cancer cells and giving cancer cells the very thing they need to grow and spread.     City of Hope and TGen physician-scientist Yun Rose Li, M.D., Ph.D., has been called trailblazing and innovative by the NIH in her research into oxidative stress and its effects on cancer cells. Dr. Li is using a five year, nearly $2 million grant to study how manipulating oxidative stress can improve the outcomes of her patients with genitourinary cancers.     Recruited for her research while still a resident at UC San Francisco, Dr. Li is quickly proving it no longer takes a lifetime in cancer research to make a difference in the lives of patients.

Host: Doug Draper (Kansas 1992)Guests: Payne Schumann (Chapman 2023) and  Taylor Dintzner (Arizona State 2022)In this episode, we meet Payne Schumann (Chapman 2023) and Taylor Dintzner (Arizona State 2022), who discuss fundraising for Chapman's Purple Tie Dinner and Arizona State's Shave to Save philanthropy events, respectively. Once you are finished watching this episode, please take our 5-minute podcast survey at www.phigam.org/PodcastSurvey.

In part two of TGen Talks Live, we continue our conversation on precision aging with Drs. Matthew Huentelman and Nicholas Schork. Aging encompasses a variety aspects—both physical and mental—a fact made evident by the topics covered and the research presented. Where Huentelman's work covers the brain and the more cognitive aspects of aging, Schork's work focuses on the physical changes we undergo as we age. This month, in part two of our live show, our guests talk about how the COVID pandemic affected our bodies and brains, and how we can best separate fact from fiction when it comes to anti-aging supplements.

TGen offers listeners a deeper dive into a particular biomedical-related topic or program through its monthly podcast TGen Talks. Each free-flowing episode allows a TGen scientist to connect with a broader audience by explaining the finer details involved in their research at a listener-friendly level. December's episode escapes the sound booth for a live event in front of a studio audience. The inaugural TGen Talks Live features Drs. Matthew Huentelman and Nicholas Schork who join our host Karie Dozer for an in-depth conversation on precision aging. A continuation of TGen's 20th Anniversary celebrations, the event, hosted by the TGen Foundation and sponsored by Phoenix IDA and Bell Bank, took place at the Center for Positive Media. Aging encompasses a variety of aspects—both physical and mental—a fact made evident by the topics covered and the research presented. Where Huentelman's work covers the brain and the more cognitive aspects of aging, Schork's work focuses on the physical changes we undergo as we age. Topics discussed included how genetics influences aging, current research, lifestyle choices and the benefits of off-the-shelf supplements and whether they live up to the hype. Can't wait for part II? Catch the full taping on TGen's YouTube channel at: https://youtu.be/N29DaTB8Jg8

Cancer is the number one worry of pet parents, and it's no wonder. More than half of all dogs older than 10 will be diagnosed with cancer. Cancer is hard to treat in many dogs, and is often diagnosed when it's too late to treat. Americans spent more than $120 billion on their pets just last year. One TGen subsidiary is putting its science to work for pet parents, so that cancer in dogs is diagnosed before it's too late. Vidium Animal Health is a wholly owned subsidiary of TGen and it works to diagnose and treat canine cancers.

There's a sleeping giant in every single man. Awakening those giants within and turning them into legends is a desire that every single man has in his heart. As we navigate life, a lot of us are searching for external things we can do to awaken these sleeping giants. However, this awakening starts. As an inside job.  Brian Bogert is the proud father of 2 children and loving husband, Brian helps coach his clients to find a balance or integration between their life and work. He has a B.S. in Business Administration and a B.A. in Psychology from the University of Redlands. Brian is known for his positive leadership and is a strong supporter of non-profit and philanthropic foundations. He has served on advisory boards and committees such as the American Cancer Society, Adelante Healthcare, TGEN, United Blood Services, the YMCA, Scottsdale Leadership and Valley Leadership. He is also the founder of the Phoenix Children's Hospital Patient and Family Leadership (PALs) group, which is dedicated to giving patients and their families the best possible experience during their treatment. He is co-creator of the mobile app, Simply Sayin' to help children understand confusing medical terms involved in their care.  Brian Bogert's life purpose is to help awaken the sleeping giant in every human being by helping them grasp that which is just out of reach. In a disconnected world, Brian is revolutionizing the way people, leaders and entrepreneurs connect deeply with their authentic self to achieve the best version of themselves thanks to his life philosophy on "how to embrace pain to avoid suffering", "people before profits" and "who before what" have helped individuals and businesses discover and activate their unlimited potential. Show Notes: https://www.thedadedge.com/390

With COVID infections and deaths on the decline worldwide, many researchers are turning their attention back to a familiar foe. Tuberculosis (TB) was the number one infectious disease killer before the emergence of COVID-19, and it is number one again today.   Although most Americans are not at risk of contracting TB, it continues to be a danger worldwide. TGen researchers are trying to find better diagnostics for this very stubborn bacterial infection, and combat antibiotic resistance so that doctors everywhere can better treat this ancient illness.   TGen North research scientist Megan Folkerts joins TGen Talks to discuss TB's history, Egyptian mummies, TGen North's efforts to design better diagnostics, learning how antibiotic resistance stunts treatment, and improved ways to overcome its effects on new or current therapies.   All this and more on TGen Talks.

We are born in our most authentic, brightest burning light, but then the world screws us up. Most people hide themselves. That is why we are not that authentic even when we say we are. How can you embrace the pain to avoid suffering? How can you learn to not be stuck by the things that have happened to you and move by what you can do to them? If you could go back, would you change if you could? Brian Bogert's passion for positive leadership extends beyond his business career and into the nonprofit sector. His driving principle, “if and how I can help” led him to be a founding member of the Society of St. Vincent de Paul's professional advisory board, the Vinnies. Brian's philanthropic work includes positions on various other advisory boards and committees like the American Cancer Society, Adelante Healthcare, TGEN, United Blood Services, the YMCA, Scottsdale Leadership, and Valley Leadership. He is also the founder of the Phoenix Children's Hospital Patient and Family Alumni Leadership (PALs) group, which is dedicated to giving patients and families the best experience possible during their treatment.  This week's Healthcare Hacks and Connections, Nathan Navas and Brian Bogert will talk about the experiences that you've gone through that have impacted you and how to achieve your authentic self despite all the challenges coming your way.  They will touch on such topics as:So many are walking around with some level of armor and protection because who they are may or may not align with who the world is telling them to be. All these dynamics that come into play through emotional triggers and behavioral patterns all lead to the element that sometimes people are not conscious of the fact that they are carrying their armor.Human experiences are so important for us to be free among everybody around us, which we all seek and desire in so many ways, but it is also the scariest place to be.We have the ability to tap into and collect ways of other people's lessons to shorten our own learning curve.Your story can extract a number of lessons that have shaped not only who you are today, but the tools, resources, processes, and pathways to healing that you have used in your own life to be able to fully give other people that same freedom and connection with who they are.If you hadn't experienced the things you have overcome, you would have lacked perspective in so many ways that can contribute to the depths of who you are.When you start to unpack, unwind, and reduce the layers that the world has put on you, who you actually are is amplified with even more beauty of trauma.We have to surround ourselves with people to complement who we are so that it will leverage and scale our lives.We have to establish a habit in every area of our life that makes it an investment in our future selves.Money is a tool that allows people to gravitate as much as they want in the world.It is not about having as much money as possible, it is having as much money as you feel you need to live the life that you want. Hack: Every single one of us has a unique story. What's important is that we learn how to pause and become aware of the lessons we can extract from our stories and become intentional about how we can apply them in our lives. We all have that ability. Additional Resources:Reach out to Brian:Website: https://brianbogert.com/media/FREE COURSE OFFER: http://nolimitsprelude.com/ Reach out to Me:Socials:Instagram: @thepodcast_docFacebook: www.facebook.com/nate.navas Affiliates:physiomemes.com (Discount code = Nate20)www.poddecks.com (Discount code = PODDOC)

For Crystal Hepp, PhD, the newest member of the TGen North team, understanding how different pathogens move over time and space and through different populations is all in a day's work. Recently, that work has centered heavily on RNA viruses, and given that the translational aspects of her work aligned seamlessly with the TGen North team and its mission, the decision to join the team came fairly easy. Spread through the bite of the common house mosquito, West Nile virus is the leading cause of mosquito-borne disease in the United States. Hepp discusses her work with county vector control agencies throughout the southwest to collect and test mosquitoes, work that helps identify locations that are viral hot zones. Additionally, Dr. Hepp discusses a unique method for collecting local wastewater samples across wastewater treatment plants, local school districts, and university residence halls testing for COVID —a partnership between the City of Flagstaff, Coconino County Health Services, Northern Arizona University, and TGen— and plans for a study to look for coronaviruses in different animal populations to understand which populations might be able to be reservoir species, then estimate when or if spillover back into humans could occur. All this and more on TGen Talks.

This episode of TGen Talks takes the listener along I-17 from Phoenix to Flagstaff, where our host, Karie Dozer, sits down with David Engelthaler, Ph.D., professor and director of TGen's Pathogen and Microbiome Division, more commonly known as TGen North.   Whereas TGen uses genomics to solve complex problems such as cancer and Alzheimer's disease, the scientists at TGen North use these same tools and technology to focus on infectious disease … the microbes, the bacteria, the viruses, the fungi that cause some of the greatest problems around the world.    Engelthaler provides the listener an inside look at the research underway across the division, and the community work with different tribal nations and hospitals to understand what's most important to them and how TGen North can apply their expertise to support those needs.   Whether it's Cryptococcus, tuberculosis, superbugs in our hospitals, or other bad things like plague, West Nile, Valley fever, COVID, or the latest efforts around pathogen intelligence, TGen North's goal is and always has been to rapidly identify and help stop the spread of potentially dangerous outbreaks.   All this and more, on TGen Talks.

My guest today is Brian Bogert, a human behavior and performance coach, speaker, and business strategist, Brian teaches disruptive strategies on how to create sustainable growth and lasting change personally and professionally. His life philosophies on “how to embrace pain to avoid suffering,” “people before profits,” and “who before what” has helped individuals and companies discover and activate their limitless potential. In a world that is disconnected, Brian is revolutionizing how individuals, leaders, and entrepreneurs deeply connect with their authentic selves to achieve the best version of themselves. Brian’s passion for positive leadership extends beyond his business career and into the nonprofit sector. He is a founding member of the Society of St. Vincent de Paul’s professional advisory board, the Vinnies, and serves on various other advisory boards and committees like the American Cancer Society, Adelante a lonte —Healthcare, TGEN, United Blood Services, the YMCA and many more! Talking Points: Brian's unique origin story The difference between pain and suffering Embracing pain to avoid suffering; but pain is not always what we need to embrace How embracing pain relates to leadership teams and building cultures Identifying pains you tend to avoid; how leaders relate this to strategies that don't seem to work How emotional triggers hold you back personally and professionally Scarcity vs. abundance mindsets How do companies take these insights to establish an effective culture? Dropping your body armor to allow everyone to be seen and heard Work/life balance versus work/life integration

My guest today is Brian Bogert, a human behavior and performance coach, speaker, and business strategist, Brian teaches disruptive strategies on how to create sustainable growth and lasting change personally and professionally. His life philosophies on “how to embrace pain to avoid suffering,” “people before profits,” and “who before what” has helped individuals and companies discover and activate their limitless potential. In a world that is disconnected, Brian is revolutionizing how individuals, leaders, and entrepreneurs deeply connect with their authentic selves to achieve the best version of themselves.Brian's passion for positive leadership extends beyond his business career and into the nonprofit sector. He is a founding member of the Society of St. Vincent de Paul's professional advisory board, the Vinnies, and serves on various other advisory boards and committees like the American Cancer Society, Adelante a lonte —Healthcare, TGEN, United Blood Services, the YMCA and many more! Talking Points: Brian's unique origin storyThe difference between pain and sufferingEmbracing pain to avoid suffering; but pain is not always what we need to embraceHow embracing pain relates to leadership teams and building culturesIdentifying pains you tend to avoid; how leaders relate this to strategies that don't seem to workHow emotional triggers hold you back personally and professionallyScarcity vs. abundance mindsetsHow do companies take these insights to establish an effective culture? Dropping your body armor to allow everyone to be seen and heardWork/life balance versus work/life integration Brian's Exclusive Offer for Listeners: http://www.nolimitsprelude.com/Resources/Links:Brian's Website: https://brianbogert.com/Connect with Brian on Instagram: https://www.instagram.com/bogertbrian/Connect with Brian on YouTube: https://www.youtube.com/c/BrianbogertCompanies/videosConnect with Brian on Twitter: https://twitter.com/BogertBrianConnect with Brian on LinkedIn: https://www.linkedin.com/in/brianbogert/Talent Empowerment Website: https://www.talentempowerment.com/Our Sponsors:LeggUP: https://www.leggup.com/

This year marks the 20th anniversary of TGen's founding on what at the time was a relatively unknown idea outside the circles of academia and scientific research, precision medicine. The concept of using a person's own genome to diagnose and treat disease at an individual level, to move beyond the one-size-fits-all treatment plans that had dominated the medical landscape for decades, where drugs and therapies considered large groups of people with the same disease, and what worked for the majority. A true public-private partnership, TGen came to fruition through the work of tribal leaders, CEOs, philanthropic trusts, foundations, individuals and university presidents, all united toward an extraordinarily high-risk goal: Forming and funding an institute based on the just-completed Human Genome Project and placing it not in Boston, San Francisco or Washington, D.C., but in Phenix, Arizona. TGen founder, Dr. Jeffrey Trent, joins TGen Talks to discuss the institute's beginnings as well as how over the past 20 years, TGen faculty have leveraged the human blueprint to advance the diagnosis and treatment of various cancers, neurologic and metabolic diseases such as Alzheimer's, diabetes, and rare disorders.

There is a sleeping giant in every human. Awakening those giants within and turning them into legends, by helping individuals grab just what's out of their grasp, is Brian's purpose in this life. Brian is a heart surgeon without a blade. He does not start outside with what you need to do, he starts inside with who you are. In a world that is disconnected, Brian is revolutionizing how individuals, leaders, and entrepreneurs deeply connect with their authentic selves to achieve the best version of themselves. As a human behavior and performance coach, speaker, and business strategist Brian teaches disruptive strategies on how to create sustainable growth and lasting change personally and professionally. His life philosophies on “how to embrace pain to avoid suffering,” “people before profits,” and “who before what” has helped individuals and companies discover and activate their limitless potential. You can literally feel Brian and his team's authenticity and will be moved by their vision to impact a billion lives by 2045. Brian's passion for positive leadership extends beyond his business career and into the nonprofit sector. His driving principle, “if and how I can help” led him to be a founding member of the Society of St. Vincent de Paul's professional advisory board, the Vinnies. Brian's philanthropic work includes positions on various other advisory boards and committees like the American Cancer Society, Adelante Healthcare, TGEN, United Blood Services, the YMCA, Scottsdale Leadership, and Valley Leadership. He is also the founder of the Phoenix Children's Hospital Patient and Family Alumni Leadership (PALs) group, which is dedicated to giving patients and families the best experience possible during their treatment. Brian's injury care at the Phoenix Children's Hospital was absolutely crucial to his successful recovery, and he is honored to continue to be a part of the hospital's family. In 2013 Brian took his initiatives a step further by co-creating the mobile app, Simply Sayin' to help children understand confusing medical terms involved in their care. With more than 75,000 downloads in over 100 countries since launch, Brian's work delivered upon the “if and how I can help'' principle with a lasting legacy for the patients behind him. https://brianbogert.com/ http://nolimitsprelude.com/ Follow us on Instagram: @TheMorningSpotlight Email us at: themorningspotlight@gmail.com www.themorningspotlight.com For title insurance inquiries contact Mike at michael.ham@ctt.com Buy Mike a Coffee!

After both of her children were diagnosed with autism and she saw the need to provide parents with emotional, physical, and educational support, Michele Knowlton-Thorne founded DAMES LLC, which became Care for the Caregivers. As President of Care for the Caregivers, Michele plans to continue creating programs, apps, events, and support groups to help parents who are raising children with different health care needs. Before founding D.A.M.E.S and Care 4 the Caregivers Michele worked as a geneticist at TGen and has an undergraduate degree in Molecular Biosciences and Biotechnology and a Master of Science Degree from Arizona State University. She also worked as an adjunct professor, re-wrote biological manuals for ASU, published in peer-reviewed journal articles, and is the author of a STEM picture book series. She is a Certified Autism Specialist and a graduate of the Pilot Parents of Southern Arizona Partners in the Leadership program. She has been trained as a Flourishing Families Practitioner, a Protective Factors Trainer, and a Triple P Stepping Stones Practitioner. Michele also sits on the ALTCS Advisory Council as a parent representative and the ICC Financial Committee. To stay connected with Jess, head to www.jessplusthemess.com.  If you are interested in being a guest please contact me at jess@thelucasproject.org. I'd love to hear what you think, so please rate and review! --- Support this podcast: https://anchor.fm/jess-ronne/support