JACC Speciality Journals

In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study of ventricular tachycardia ablation in patients with active cardiac sarcoidosis. Using integrated FDG-PET and cardiac MRI imaging, the investigators found that VT exit sites were often located in areas of active inflammation, while more proximal circuit sites were associated with scar. Patients in whom only VT exit sites could be identified had substantially higher VT recurrence rates, suggesting that targeting deeper portions of the VT circuit may improve outcomes.

Nicole Bhave, Ashwini Kerkar, and Ahmed Kamal Siddiqi discuss what inspired this study, differences in mortality trends among age groups, and the most important takeaways from the paper.

In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating how CT-defined myocardial ridges and functional mapping can be combined to identify critical ablation targets in post-infarction ventricular tachycardia. The investigators found that VT target sites frequently localized to CT-defined ridges, particularly those associated with primary deceleration zones, suggesting that functional mapping can help distinguish active arrhythmogenic ridges from inactive ones and support more targeted VT ablation.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Audio Summary of the August 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.

Audio Summary of the July 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.

Matt Martinez and Bradley Petek discuss how the study came about, what results were discovered, and what call to action this study brings.

Commentary by Dr.  Kevin Ka-Ho Kam

Commentary by Dr.  Lei Song

Audio Summary of three articles from the August 2026 issue of JACC: Advances.

Michael Wilkinson, Dinesh Kalra, Liam Brunham, and Robert Rosensen discuss the motivation behind the ACCURATE Study, unmet needs in identifying and treating HeFH, and how future studies can be designed to address the unmet need of identifying patients with HeFH and starting intensive LLT earlier in life.

Dinesh Kalra and Khadijah Breathett discuss the estimated future projections of risk factors for CVD, individual CVD conditions (i.e. heart failure), and total CVD from 2020 to 2050 according to SDOH of the U.S. using the National Health and Nutrition Examination Survey, Medical Expenditure Panel Survey, and U.S. Census.

In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating whether abrupt wall-thickness transitions on cardiac CT scans can help identify critical ventricular tachycardia (VT) substrate in patients with ischemic cardiomyopathy. The investigators found that these CT-derived structural markers frequently co-localized with VT isthmus boundaries and deceleration zones identified during electrophysiology studies, suggesting they may complement traditional mapping techniques and help guide VT ablation, particularly when arrhythmias are difficult to map.

Dinesh Kalra and Javed Butler discuss the development of an artificial intelligence screening tool to identify high-risk patients who should be considered for diagnostic testing for ATTR-cardiomyopathy (ATTR-CM) from an unselected heart failure (HF) population.

Francis E. Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses the S3-STaMP study, which evaluated a novel mapping strategy for patients with hemodynamically unstable ventricular tachycardia (VT). The investigators found that STaMP mapping, guided by the S3 functional mapping protocol, rapidly identified critical VT circuit pathways in nearly three-quarters of patients and did so without causing acute hemodynamic deterioration. These findings suggest that S3-guided STaMP mapping may offer a safe and practical approach to improve catheter ablation of otherwise difficult-to-map VT.

Dr. Ky's August 2026 Issue Summary.

Commentary by Dr. Duk-Woo Park.

Commentary by Dr. Deng Ye on behalf of Leilei Cheng.

Commentary by Dr. Joshua Levenson.

Commentary by Dr. Adithya Yadalam.

Commentary by Dr. Kevin Tang.

Commentary by Dr. Kevin Tang.

Commentary by Dr. Fu-Zong WU.

Commentary by Dr. Xin Zhou.

Commentary by Dr. Hyeon Chang Kim.

Commentary by Dr. Łukasz Kuźma.

Commentary by Dr. Ekamol Tantisattamo.

Commentary by Dr. Barry Franklin.

Nicole Bhave, Michael Reardon, and Joe Aoun discuss what inspired their paper, the unique microbiology of TAVR endocarditis, and a challenging endocarditis case example.