JACC Speciality Journals

Audio summary of JACC: CardioOncology's June issue.

This podcast by Dr. Larissa Araújo de Lucena discusses the development of the ONCO‑DOAC BLEED score for predicting major bleeding in patients with cancer‑associated venous thromboembolism (VTE) receiving direct oral anticoagulants. The findings support a more personalized, risk‑based approach to anticoagulation in cardio‑oncology, integrating cancer type, comorbidities, and clinical factors while highlighting the need for broader validation.

This podcast by Dr. Ron Witteles reviews new data on transthyretin amyloid cardiomyopathy (ATTR‑CM), highlighting differences in transthyretin stabilization between acoramidis and tafamidis across wild-type and variant disease. The discussion underscores the clinical importance of TTR stabilization, emerging biomarkers such as serum transthyretin, and the expanding therapeutic landscape in cardiac amyloidosis.

This podcast by Dr. Dan Zlotoff reviews new research on immune checkpoint inhibitor–associated myocarditis, a rare but serious complication of cancer immunotherapy, focusing on emerging inflammatory biomarkers such as interleukin‑6 and immune cell signatures. The study highlights potential pathways for risk stratification and targeted therapies, while underscoring the need for larger trials to develop reliable diagnostic and treatment strategies in cardio‑oncology.

This podcast by Dr. António Araújo highlights new insights from a large international registry study showing that cancer‑associated upper extremity deep vein thrombosis (UEDVT) carries increased risks of recurrent venous thromboembolism and bleeding. The findings emphasize tumor‑specific risk patterns and support more personalized anticoagulation strategies in cardio‑oncology.

This podcast by Dr. Marie Pigeyre explores emerging evidence on clonal hematopoiesis, highlighting its role as a systemic driver of inflammation and its association with increased risk of cardiovascular disease, stroke, and type 2 diabetes. The discussion emphasizes the growing importance of clonal hematopoiesis in cardiometabolic risk, precision prevention, and aging biology, while noting that routine clinical screening is not yet recommended.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Differential Association Between Surrounding Greenness and Mortality in Individuals With Coronary Heart Disease.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Cardiac Involvement in Adults With Myotonic Dystrophy Type 1: A Multicenter Study.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Characteristics, Management, and Outcomes of Diabetes Subtypes in Patients With Cardiogenic Shock: A Nationwide Analysis.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Comparison of Microcirculation in Chronic Heart Failure, Cardiogenic Shock, LVAD, and Heart Transplantation.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Generalizability of Landmark Temporary MCS Device Trials: Insights From the CSWG Registry.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Long-Term Outcomes of Targeted Volume Overload Management in Patients With Severe Aortic Stenosis.

Dr. Mohamad Alkhouli speaks with Dr. Wayne Batchelor about what leadership truly means for mid‑career interventional cardiologists and whether pursuing an MBA adds value. Dr. Batchelor highlights trust, communication, and business fluency as essential skills for physician leaders navigating increasingly complex healthcare systems.

Dr. Mohamad Alkhouli and Dr. Kirk Garratt discuss leadership in interventional cardiology, highlighting the importance of empathy, communication, and advocacy alongside clinical expertise. Dr. Garratt encourages physicians to intentionally develop leadership skills—through training or experience—as healthcare systems become more complex.

In this conversation, Dr. Mohamad Alkhouli speaks with Dr. Abbott about her leadership journey in interventional cardiology, focusing on how curiosity, mentorship, and skill development organically lead to meaningful leadership roles. Dr. Abbott shares practical insights on motivating teams, navigating complex healthcare systems, and whether formal business training such as an MBA is necessary for physician leaders.

Dr. Mohamad Alkhouli and Dr. Deepak Bhatt discuss leadership development in interventional cardiology and the value of pursuing an executive MBA mid‑career. Dr. Bhatt shares insights on how business training—from finance to leadership and strategy—can help physicians navigate increasingly complex healthcare systems and become more effective stewards of patient care and resources.

Commentary by Dr. Katsuhiko Imai.

Commentary by Dr. Satoshi Shizuta.

Commentary by Dr. Deep Chandh Raja.

Commentary by Dr. Leandra Serio.

Deputy Editor Kenneth Ellenbogen presents an in‑depth discussion of the study "Long PR Interval Leads to Atrial Remodeling, Fibrosis and Inducible Atrial Fibrillation in a Swine Model." In this episode, Dr. Ellenbogen walks listeners through how prolonged atrioventricular conduction can drive structural and electrical remodeling in the atria, leading to fibrosis and increased susceptibility to atrial fibrillation. He highlights the significance of these findings for understanding AF pathophysiology and considers how this preclinical model may inform future prevention and treatment strategies.

In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel pulsed field ablation–based endocardial strategy for ventricular tachycardia in patients with arrhythmogenic right ventricular cardiomyopathy. The paper presents an early consecutive experience demonstrating the feasibility, acute effectiveness, and safety of PFA for VT without the need for epicardial access. Dr. Marchlinski highlights the clinical implications of this approach and how tissue-selective, nonthermal energy may expand treatment options for this challenging patient population.

In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a large multicenter study evaluating the incidence and clinical significance of aortic regurgitation following mapping and ablation of ventricular arrhythmias in the aortic cusps and commissures. Drawing on contemporary data from four high‑volume centers, the paper provides important reassurance regarding the safety of aortic cusp ablation, demonstrating that clinically significant aortic regurgitation is rare and infrequently progressive. Dr. Marchlinski highlights the key findings, procedural considerations, and implications for everyday practice in ventricular arrhythmia ablation.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Socioeconomic Status With Cardiorenal Metabolic Multimorbidity: Evidence From the UK Biobank Cohort.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Remote Management of Patients With Heart Failure in Medically Underserved Areas.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Development of a Predictive Tool in Patients With High Pretest Probability for Transthyretin Amyloid Cardiomyopathy.