Podcasts about adiposity

“歩くスピードが遅い人”は寿命が短い傾向　やせ型なら最大20年低く　47万人以上で検証、英国チームが19年に発表。　英レスター大学などに所属する研究者らが2019年に発表した論文「Comparative Relevance of Physical Fitness and Adiposity on Life Expectancy」は、身体能力と肥満度が平均寿命にどのように影響するのかを詳しく調査した研究報告である。特に注目したのは、自己申告による歩行ペースと握力計で測定した握力という2つの身体能力指標である。

In this episode, we explore how inflammation, autoimmune diseases, gut health, and chronic conditions are connected. We break down the roles of the vagus nerve and acetylcholine in controlling the immune system, focusing on issues like obesity and body fat. We also talk about how fat tissue triggers inflammation and share practical tips like intermittent fasting, balanced nutrition, and exercise to improve your health.We highlight the benefits of cutting down on carbs, eating more protein and healthy fats, and avoiding too many processed foods. The episode also looks at how modern eating habits affect metabolism and how past diets can guide us toward healthier choices today. Tune in for easy lifestyle changes to boost your health!Dr. Navaz HabibEmail: podcast@healthupgraded.comFacebook: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabibJP ErricoLinkedIn: https://www.linkedin.com/in/jp-errico-097629aa

In this episode, Dr. Josh Mitchell reviews a significant study that explores the links between physical health markers, such as waist circumference and hand grip strength, and cardiovascular outcomes in men with prostate cancer undergoing androgen deprivation therapy. The findings indicate that increased waist circumference and decreased grip strength are associated with higher cardiovascular event risks, highlighting the need for targeted interventions like exercise in these patients and emphasizing the importance of further research in diverse populations.

Audio Commentary by Dr. Valentin Fuster, Emeritus Editor in Chief

Tanya Halliday, PhD, RD is an Assistant Professor in the Department of Health, Kinesiology, and Recreation at the University of Utah. Her research focuses on appetite and food-intake regulation in response to lifestyle interventions such as dietary restriction and exercise. Currently, she is investigating how type of exercise (e.g., aerobic vs resistance) influences hormonal and behavior indices of appetite regulation, and mechanisms underlying response variation in body mass regulation with exercise. Another current area of research focus is on development of effective weight loss maintenance strategies. Dr. Halliday is also examining how sex as a biological variable, may influence the appetitive responses to energy deficits elicited through both increased exercise energy expenditure and caloric restriction.  She received her PhD in Clinical Physiology and Metabolism from Virginia Tech in 2016, where her research focused on exercise and dietary interventions for the prevention and treatment of obesity and related cardiometabolic conditions. She is also a Registered Dietitian, having completed her BS in Dietetics in 2010 at the University of Wyoming, and her Dietetic Internship through the University of Houston in 2011.  We have a conversation about the change in obesity rates over the last 50-60 years and what the current epidemiology states regarding the impact on populations and general health.  We discuss traditional energy balance teachings and whether a “calorie is a calorie” as it relates to weight loss.  Professor Halliday discusses GLP-1 medications, what problems they meant to solve and for which candidates and explains the side effects.  We talk about the efficacy of exercise for improved health and weight loss and whether wearable technology can assist health outcomes.  Tanya Halliday, PhD, RD Full Biogrophy and Research Agenda    Tanya Halliday, PhD, RD on Xhttps://x.com/NutritionNerd  Tanya Halliday, PhD, RD on Instagramhttps://instagram.com/NutritionNerd    Follow Us:Facebook: https://Facebook.com/EventHorizon.TvX: https://twitter.com/EventHorizonTvInstagram: https://instagram.com/eventhorizon.tvYouTube: https://youtube.com/c/EventHorizonTvSupport Us:https://Patreon.com/Endurance

Looking at the complex relationships between adversity in childhood and obesity in adulthood, with Shakira Suglia, Emory University

Looking at the complex relationships between adversity in childhood and obesity in adulthood, with Shakira Suglia, Emory University

Links: Go to episode page Subscribe to Premium Join the Sigma email list Go to our recommended resources About This Episode: Have you ever wondered how exercise affects our appetite and energy intake? While we know that single bouts of exercise can create a short-term energy deficit, do they also influence our hunger levels? And what about long-term exercise training? Could it modify our appetite in ways that help us better control our weight? Recent research suggests that exercise may indeed play a role in appetite regulation. Could exercise modify the subjective and homeostatic mediators of appetite in ways that enhance our feelings of fullness after a meal? One of the most fascinating aspects of this research is the variability in responses between individuals. Why do some people experience changes in appetite and energy intake after exercise, while others don't? Could factors like adiposity, sex, or habitual physical activity levels play a role? In this episode, Dr. James Dorling of the University of Glasgow helps us delve into the evidence surrounding how factors like adiposity, sex, and habitual physical activity modulate our responses to exercise in terms of appetite, energy intake, and appetite-related hormone responses. About The Guest: Dr. James Dorling is a lecturer in Human Nutrition at the University of Glasgow. Dr. Dorling's research is broadly focused on three areas: (1) the impact of nutrition and physical activity interventions on obesity-related endpoints and biomarkers of aging; (2) the regulators of appetite and eating behaviours; and (3) the changes in appetite and eating behaviours in response to health interventions. During his PhD, he studied the effects of acute exercise and obesity-related single nucleotide polymorphisms on appetite and appetite-related hormones. Following this, Dr. Dorling joined Pennington Biomedical Research Center where he worked as a postdoctoral researcher. His postdoctoral research principally focussed on the influence of calorie restriction and physical activity on weight, markers of aging, and eating behaviours.

Dr Malfliet was on today discussing her PhD thesis paper which deserves a lot of attention. We discussed her RCT entitlted "Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial" where we focused on the importance of nudging into pain (Time Contingent Exercise), reframing motor control exercises as movements that you get comfortable and confident in moving and how to progress these exercises with a graded exposure/activity approach. We also talked about the role of losing weight (specifically adipose tissue) and its potential role in managing persistent pain.  Weight loss is a difficult topic to broach with patients and providers and we touched on these issues.  We didn't spend too much time on this contentious topic and its certainly worth exploring more in detail   Our Guest - Anneleen Malfliet Anneleen Malfliet is an assistant professor and postdoctoral researcher at the Vrije Universiteit Brussel. She is also a member of the Pain in Motion international research group. Her research and clinical interest goes out to chronic pain with a special interest in chronic spinal pain, pain rehabilitation, central sensitization, nutrition and diet. More info at our Pain in Motion website: www.paininmotion.be

Would it surprise you to know that you don't need to lose weight to get out of pain? I frequently get messages that include something along the lines of “I know I need to lose weight but…” which breaks my heart because I believe that life without pain is possible for everyone - no matter what your body looks like or feels like right now. We've been sold this idea that the pain in our joints is directly related to body mass. But time and time again - the research does not find this to be true. You don't need to lose weight to get out of pain. And the idea that some amount of pain is something we have to just “live with” because of our age or body type is nonsense. You'll learn: Why you don't need to lose weight to get out of pain Why focusing on BMI is a waste of time (and missing the point) How there is no definitive scientific link between body mass, weight loss, and pain All the links: The association between chronic pain and obesity. J Pain Res. 2015;8:399-408. Published 2015 Jul 14 Evers Larsson, U. Influence of weight loss on pain, perceived disability and observed functional limitations in obese women. Int J Obes 28, 269–277 (2004). Effect of weight loss on musculoskeletal pain in the morbidly obese. The Journal of Bone and Joint Surgery. British volume 1990 72-B:2, 322-323 Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach, The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 1, 1 January 2010 Join me for the next Movement Mavens Retreat! www.aewellness.com/retreat/ 30 days to more strength + flexibility with the Mobility Mastery Toolkit www.aewellness.com/podcast - Show notes, links and more. Come hang out with me on Instagram @hollaformala : https://instagram.com/hollaformala/ TikTok @ aewellness Bodywork Starter Guide - learn the 6 places you need to roll right now for quick relief, plus the reason why what you've tried so far has only given you a temporary fix. Download the guide for free now at www.aewellness.com/bodywork 818-396-6501 is the Body Nerd Hotline - how do you build consistency and/or where are you getting stuck? Drop me a line and let me know your body nerd hacks - you might just hear your voice on a future episode! Today's episode is brought to you by Mobility Mastery Toolkit. Forget icing and stretching - and get a simple program you can do on your own that actually works. The Toolkit includes 30-days of exercises so you know exactly what to do to improve the mobility of your hips, lower back, feet, neck and shoulders. With video demos and a full-body mobility workout calendar, you're just 15-mins a day from feeling stronger and more flexible. Get $20 off when you use the code MASTERY at www.mobilitytoolkit.co

Have you heard of the Saggital Abdominal Diameter (SAD)?   How might we use SAD to height ratio in place of BMI?  Join host, Karli Burridge, as she reviews a recent journal article about a cost-effective and simple measurement technique for assessing excess adiposity risk that can be more accurate than body mass index (BMI).Article:  Replacing the body mass index with the sagittal abdominal diameter (abdominal height) - PubMed (nih.gov)Support the showThe Gaining Health Podcast will release a new episode monthly, every second Wednesday of the month. Episodes including interviews with obesity experts as well as scientific updates and new guidelines for the management of obesity.If you're a clinician or organization looking to start or optimize an obesity management program, and you want additional support and resources, check out the Gaining Health website! We offer monthly and annual Memberships, which include live group coaching, a community forum to ask questions and post resources, pre-recorded Master Classes, digital resources inlcuding patient education materials and office forms, and much more! We also sell our popular Gaining Health products, including a book on developing an obesity management program, editable forms and templates, and patient education materials in our Gaining Health Shop! If you are loving this podcast, please consider supporting us on Patreon

According to the National Institutes of Health, more than two in five adults have obesity in the United States, and nearly one in three is overweight. To equip health care practitioners with the resources they need to treat patients with obesity, the Endocrine Society recently held its innaugual obesity fellows program, an exclusive, application-based, educational activity for current fellows. The program covered a wealth of information, and host Aaron Lohr talks with Amy Rothberg, MD, DABOM, program chair and a clinical professor of internal medicine at the University of Michigan’s School of Public Health. If you weren’t able to attend the fellows program, we have a free series of on-demand lectures available online, and those are accredited. With thanks to Lilly USA LLC and Novo Nordisk for making both the obesity fellows program and this podcast episode possible through an unrestricted, educational grant. Show notes, including a link to the Endocrine Society Learning Center for earning ABIM points and AMA PRA Category 1 credits, are available at https://www.endocrine.org/podcast/enp81-obesity-fellows-program — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

According to the National Institutes of Health, more than two in five adults have obesity in the United States, and nearly one in three is overweight. To equip health care practitioners with the resources they need to treat patients with obesity, the Endocrine Society recently held its innaugual obesity fellows program, an exclusive, application-based, educational activity for current fellows. The program covered a wealth of information, and host Aaron Lohr talks with Amy Rothberg, MD, DABOM, program chair and a clinical professor of internal medicine at the University of Michigan’s School of Public Health. If you weren’t able to attend the fellows program, we have a free series of on-demand lectures available online, and those are accredited. With thanks to Lilly USA LLC and Novo Nordisk for making both the obesity fellows program and this podcast episode possible through an unrestricted, educational grant. Show notes, including a link to the Endocrine Society Learning Center for earning ABIM points and AMA PRA Category 1 credits, are available at https://www.endocrine.org/podcast/enp81-obesity-fellows-program — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

According to the National Institutes of Health, more than two in five adults have obesity in the United States, and nearly one in three is overweight. To equip health care practitioners with the resources they need to treat patients with obesity, the Endocrine Society recently held its innaugual obesity fellows program, an exclusive, application-based, educational activity for current fellows. The program covered a wealth of information, and host Aaron Lohr talks with Amy Rothberg, MD, DABOM, program chair and a clinical professor of internal medicine at the University of Michigan’s School of Public Health. If you weren’t able to attend the fellows program, we have a free series of on-demand lectures available online, and those are accredited. With thanks to Lilly USA LLC and Novo Nordisk for making both the obesity fellows program and this podcast episode possible through an unrestricted, educational grant. Show notes, including a link to the Endocrine Society Learning Center for earning ABIM points and AMA PRA Category 1 credits, are available at https://www.endocrine.org/podcast/enp81-obesity-fellows-program — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

Obesity Canada published a guideline in 2020 that we will be referring to a lot in this episode. It defines obesity as a chronic, progressive and relapsing disease characterized by the presence of adiposity that impairs health and social well-being.    So today you'll learn what you need to know for the exam, but also some practical considerations for real life visits that take into account the pressures of diet culture, and how we as physicians can provide evidence based advice that doesn't isolate and judge our patients. And because we know language matters, you'll hear us use terms like “large bodies”, instead of saying someone is fat. There are advocates who have reclaimed the term fat, but today we'll stick with medical jargon and terms aimed to avoid stigma.  

Dr. Christina Prevett // #GeriOnICE // www.ptonice.com  In today's episode of the PT on ICE Daily Show, Modern Management of the Older Adult division leader Christina Prevett discusses that the fountain of function is muscle mass and estrogen in the aging female. Christina breaks down these two areas for function, and what we have physical therapist can do to help encourage both muscle mass and estrogen preservation. Take a listen to learn how to better serve this population of patients & athletes. If you're looking to learn more about live courses designed to better serve older adults in physical therapy or our online physical therapy courses, check our entire list of continuing education courses for physical therapy including our physical therapy certifications by checking out our website. Don't forget about all of our FREE eBooks, prebuilt workshops, free CEUs, and other physical therapy continuing education on our Resources tab. EPISODE TRANSCRIPTION 00:00 - CHRISTINA PREVETT Hello, everybody, and welcome to the PT on Ice Daily Show. My name is Christina Prevett. I am one of the team within our Modern Management of the Older Adult Division. In our division, we have three courses in our geriatric curriculum. We have our eight-week online Essential Foundations course. We have our eight-week online Advanced Concepts course. And we have our two-day live course. We have a couple of courses that are left in the remainder of the year. We have a course coming up in November in Chandler, North Carolina. We have another course coming up in South Carolina. And we have a course coming up in Texas in December. So if you are near those courses or you are looking to get in some content before the end of the year, I encourage you to check those courses out. and you'll be able to get in with some of our faculty before, you know, we ring in 2024. 01:18 - THE FOUNTAIN OF FUNCTION Today I'm going to talk about the fountain of function. And so this is a reframe that I think is really important. And we're going to talk about what those fountains of function are. You'll notice that I did not say fountain of youth. We have this idea in our society that youth is the goal, to not feel like we're getting older in any way, to not show signs of age on our faces. And don't get me wrong, I see my aging face, I was like, oh, my face doesn't look like I am 21 anymore, and I look at the wrinkles on my face, and I have those emotions. But the idea for my life is not to try and get younger. It's to try and optimize my reserve and try and live the way that I want to live with the most amount of function possible into my 30s and 40s and 50s and 60s and hopefully all the way up to 100. Because at MMA and within ice in general, Aging is a privilege. It is something that I am very thankful for because the alternative is not that great. We're not gonna be able to reverse back time, but we can have a really successful aging process, especially when we put in the steps to live the way that we want to live, whatever that filter means for us. So I'm not looking for the fountain of youth. I am looking for the fountain of function. And so the two types, the two areas that are the fountain of function in aging women, so I'm going to talk about female anatomy, is muscle mass and estrogen. And these two things, especially when taken together and optimized to the best of our capacity, is going to allow us to have more function towards the end of our life. So let's talk about muscle mass. You have not been following the Institute of Clinical Excellence in any ways if you don't know that LODE is our love language across all of our division, across all of our faculty, and that is absolutely true in the geriatric curriculum as well. And I love it so much that I did an entire PhD on the influence of resistance training in an aging body. When we look at resistance training, we are accumulating a growth and a continuation, a plethora of education and research that looks at the impact of resistance training on health outcomes. And I just posted a paper that was a narrative review from Stu Phillips, who is one of my committee members on my PhD. 04:18 - THE COMING OF AGE OF RESISTANCE TRAINING And he talked about the coming of age of resistance training and how we are starting to see some accumulation of evidence that is mirroring and is just as strong as literature that we're seeing in aerobic training to prevent stave off different chronic diseases, including some cardiovascular diseases. And so there means that there, as of course, we're going to target the aerobic system. This is not to say to not do cardio in stead, just do resistance training, but it's showing that there is a continual and persistent growth of literature talking about the impact of resistance training on health outcomes. So what we see is that those who have more muscle mass tend to have lower all-cause mortality. They are less likely to develop cardiovascular conditions. They are better able to manage diabetes. They're less likely to get diabetes. We know that muscle mass is protective around things like osteoporosis, right? Tensile strength of the bone is important and we need impact, body weight movements, resistance training across the lifespan in order to optimize that. We see that individuals who are stronger or less likely to have sarcopenia, right? Sarcopenia is clinically relevant amounts of muscular weakness that are preventing a person from completing their day-to-day tasks. It's a totally important output of frailty. Fried's physical phenotype of frailty talks about physical reserve and physical capacity as an output of individuals seeing these constellations and signs and symptoms that lead to vulnerability to external stress. That external stress includes things like hospitalizations and being able to withstand different stressors with respect to immune system insults, including things like COVID-19, pneumonia, and the flu that allows individuals, while they are sick, to have that reserve and resiliency to lean back on in order for individuals to be able to get back to baseline or improve past baseline, post-hospitalization, or acute insult. All this to say, we know that individuals need to be trying optimize their muscle mass in their earlier life and then hold on to it for as long as possible. If you are in a setting where you are not working with individuals who have optimized their muscular mass, we also know that muscular mass can be developed and we can see improvements in physical function with resistance training at any age when we start including in our 90s. The mechanism at which strength develops is a little bit different. We're looking a lot more at neuromuscular efficiency. However, we can absolutely see that it can improve function. And so whether you are 30 or you are 85, muscle mass is a fountain of function and it allows us to withstand stress. 12:24 - ESTROGEN FUNCTION & MENOPAUSE  Now let's kind of talk about this second piece, which is estrogen. I've done several podcasts on menopause, but I want to talk about the influence of estrogen around female physiology, because I think this is really important. So when we are going through the menopausal transition, on average, individuals will start menopause between 50 and 51. Definition of menopause is when you've gone a full calendar year, 12 months without a menstrual period. That is your menopausal transition. But individuals can be experiencing perimenopausal symptoms that are indicators of dwindling or are coming down of estrogen status for up to 10 years prior to the transition into menopause. And so individuals who are in their early 40s can start to see the influences of loss of estrogen on their body. And then that influence is persistent as individuals get older. When we're talking about menopause, we often are putting this into two camps. So we have vasomotor symptoms, which are these symptoms that occur because of an acute withdrawal of estrogen. These are things like night sweats and hot flashes. As individuals transition through menopause and we get into our later life, into our 60s, 70s, 80s, and beyond, those symptoms tend to decline. So those vasomotor symptoms that occur as our body transitions to reductions in estrogen status they tend to go down as our body gets used to this new state of equilibrium that occurs without estrogen. In the opposite direction, the second kind of camp that we speak about when individuals are going through menopause is genitourinary syndrome of menopause or GSM. And that is signs and symptoms across the female physiology that are responding to losses in estrogen. and anywhere where there is an estrogen receptor within our body, they are going to experience changes when individuals transition through menopause. And we oftentimes will, in the pelvic health space, talk about changes to our reproductive anatomy, which are unbelievably relevant, but we have to also extrapolate that out and talk about different areas where estrogen is influencing female physiology and how, if you are working with an aging female, they are experiencing changes because of that change in estrogen status. And so within the reproductive track, we see that there is changes in ligamentous stability around the pelvis. And I hate that word stability, but it's a change in the turnover of the way that our ligaments are restructuring. So we have a little bit more ligamentous breakdown than buildup, right? That turnover rate is different. And so we have this shift between static support in the pelvis to the requirements or dynamic support around the pelvic floor. We see that individuals start to have vaginal atrophy. We see that the vaginal microbiome starts to change. We don't have the same cervical mucus secretion. And so things like chafing and redness can be more prevalent in a person who is postmenopausal. We can see fusing of the labia minora and majora. and this can lead to increased risks for pelvic floor dysfunction. So when we are in estrogen low states, rates for pelvic floor dysfunction go up. This includes anal incontinence, urinary incontinence, pelvic organ prolapse, dyspnea, or painful punitive intercourse, and other aspects of the reproductive tract. We also see, because of this change in the vulvar anatomy, that we have an increased risk for things like urinary tract infections, that increased risk for urinary tract infection also influences individual's physical function. We know that recurrent UTIs can be a cause of changes in cognitive status for our aging females. And so something that is extremely relevant for our aging women. Other things that we see is that as individuals go into an estrogen depleted state, increased risk of cardiovascular disease goes up. Individuals as they transition through menopause, we see that in general, men tend to be more impacted by cardiovascular disease. That is shifting for a lot of different reasons, but that risk profile increases when individuals are in an estrogen depleted state. We see a change in central adiposity where weight starts to increase. Adiposity accumulation can increase, especially visceral fat accumulation, which has a risk profile in and of itself for different chronic diseases. And then we see, for example, in our bone microarchitecture that the influence of estrogen allows for continual bone regeneration and that profile again starts to switch and there's an increased risk for things like osteoporosis in an estrogen deficient state. So there's a lot of things that get impacted, right? Our skin gets impacted, our breast tissue gets impacted, our urinary tract, all of our mucosal membranes, not just in our vulva, but across our entire body, and this has impacts. And so when we are thinking about working with these individuals, one of the things that is starting to become really recommended is topical estrogens. And there's a lot of debate about this because of a study that had been done a little while ago that looked at increased risk for sex-related cancers, breast cancer, endometrial cancer, cervical cancer, et cetera, with systemic estrogen. However, what we are starting to see now and many of our menopausal experts like Dr. Mary Claire and Dr. Rachel Rubin are really trying to have this public health approach to medicine saying that we are not doing our females a service when we are saying that there is a risk profile when subsequent studies have not been able to substantiate or replicate those findings. And so there's been a big shift in the last five years to the need for or the desire for many women who are really suffering with genital urinary syndrome of menopause to be able to take things like topical estrogens in order to really significantly reduce their symptom burden. And I'm not just talking about their pelvic floor, which is an extremely important part of their sexual health, also a vital sign of aging, but also, you know, all of these other physiological signs of estrogen deficiency that are impacting our outcomes, right? We see that individuals with that combination of muscular mass, we are seeing individuals with negative consequences of osteoporotic fracture. if we were able to be preventative in this approach where we are talking about estrogen supplementation when these symptoms start to arise, especially when they hit a threshold of bother, where there's going to be this spectrum, some individuals are very bothered and very impacted by the signs of vasomotor symptoms and genital urinary syndrome of menopause, and then some individuals are not, but for those individuals with bother, is this something that should be taken? Is this something that they can talk to their physician about? Is there this literature to support these topical estrogens? And we are starting to see this mounting of evidence that is starting to come up to help individuals in the aging process. So many of our aging adults are being told that this is just what they should be living with. This is because they're going through menopause. Deal. We saw this in the peripartum space where there's a lot of advocacy still happening with respect to not having this thought process that as soon as you have a baby that pelvic floor dysfunction is just something that you should live with. We're starting to see this rise up in our perimenopausal and postmenopausal population, where they are not accepting that this is what they should be doing. They're not being dismissed anymore for these symptoms, and it's super important. When we take this lifespan approach, this education becomes extremely relevant. Talking about the peripartum space, I truly believe that that is where we start to tell females that they are not resilient, that they are somehow fragile, that they need to be concerned for their organs falling out and all these different pelvic floor dysfunctions. And then they are not encouraged to be as resilient as they could be by taking part in heavy resistance training or impact activities or things at higher intensities. We start bringing that intensity down and the idea of, ooh, be careful or, oh, monitor this or, oh, if you have these symptoms, it's time for you to stop participating in those activities. We are seeing this shift and what this shift is going to do earlier in life is it's going to set up are aging individuals with this mindset that pelvic floor dysfunction one is not inevitable two that reserve is protective when it comes to muscular reserve and three they're going to be advocates for their own health and that includes their hormonal health and that includes not accepting that some of these symptoms of menopause are things that they just need to live with, but things that can be medically managed. Genital urinary syndrome of menopause is a syndrome condition. It is a medical diagnosis, and therefore it is something that we can be treating. As physical therapists, us being educators and conduits of that knowledge translation is extremely important. And then we are going to optimize function for these individuals. Last point that I'm going to make, because I ended up being a lot more long-winded than I thought I was going to be, is that we are now seeing this interaction between menopause, genital urinary syndromes, and long-term health outcomes. We are seeing that individuals with higher physical activity, combination, aerobic resistance, or both, are having a much lower GSM burden than those who are not. And so again, it comes back full circle, whether this health promotion is extremely important, that not only are we gonna optimize a person's muscular reserve, we're gonna make that fountain of function be extremely relevant, but we're also going to make the quality of that function a lot better because their quality of life is better because we are not allowing them to just live with these symptoms and be dismissed by our medical system, us included, that just expects this to be the way that it is. And so this advocacy piece is extremely important and it's something that we are going to be screaming from the rooftops. All right, everyone, I hope you have a wonderful week. I'm going to be diving a lot more onto my page and I'm going to be collaborating it with ICE and MMOA around hormone therapies for individuals with GSM. I am not a medical physician, so I encourage you to reach out to your urogynecologist and urologist in your area. Get that relationship with them so that you can start having these conversations and we can start talking about risk profiles. All right, have a wonderful week. If you are not on our MMOA digest, I encourage you to sign up for those newsletters. Otherwise, have a wonderful week and I will talk to you all again soon. OUTRO Hey, thanks for tuning in to the PT on Ice daily show. If you enjoyed this content, head on over to iTunes and leave us a review and be sure to check us out on Facebook and Instagram at the Institute of Clinical Excellence. If you're interested in getting plugged into more ice content on a weekly basis while earning CEUs from home, check out our virtual ice online mentorship program at ptonice.com. While you're there, sign up for our Hump Day Hustling newsletter for a free email every Wednesday morning with our top five research articles and social media posts that we think are worth reading. Head over to ptonice.com and scroll to the bottom of the page to sign up.

In this season two episode, Generational Gene details the serious risk of colon cancer and his two pronged approach of cycling and weight loss against three related medical issues– obesity, diabetes, and cancer, all of which run in his family.  This builds upon our season one episode where Gene described his choice of cycling to help manage blood sugar and hold off diabetes. “Some days it feels like your pedal to save your life,” Gene told us, “and in a lot of ways, you really are.” Now a high school superintendent, Gene is also a former biology teacher. “One of the things I've learned in the last couple years,” he tells us after a short training ride, “is that cellulose and fat tissue is biologically active.”  That point is echoed by our medical expert this episode, Dr. Chika Anekwe of Mass General Brigham and Harvard Medical School, who adds that “the signals that fat cells send out can be carcinogenic, or cancer-causing.” On the dietary/weight-loss front, Gene proudly recounts a story from some years ago where he lost 42 pounds in three months through crash dieting, winning a bet from a close friend. Soon after, though, he reverted to his original weight– like so many other dieters have experienced after initial weight loss.  “And that has a lot to do with this concept of the set point,” Dr. Anekwe explains, “No matter what you do to lose that weight, to bring it down, it always wants to go back to that set point.”  Challenges abound for Generational Gene on the exercise road, too. Gene participates in the annual Pan Mass Challenge, a 200-mile bike ride across Massachusetts benefiting cancer research at the Dana Farber Institute. But a training accident in the spring kept him off the bike with a hamstring injury for several important weeks.  “I just lost control of the bike and then just went down on the road,” he recalls. “And then I saw that the pedal was in the road. And I was like, man, the pedal snapped.” Will Gene have the stamina for the 100-mile Saturday leg of the PMC? Will his new bike pedals support the effort? And how about that long term, often uphill challenge of losing weight for diabetes and cancer prevention?  Tune in for chapter two of Generational Gene's body odyssey, as he pushes back against a family history of diabetes and cancer. With expert commentary from Obesity & Preventive Medicine Physician, Dr. Chika Anekwe of MassGeneralBrigham and Harvard Medical School.  My Body Odyssey is a Fluent Knowledge production. Original music by Ryan Adair Rooney. Show Notes: Experts: Name: Dr. Chika Anekwe Resources: NIH: Overweight & Obesity Statistics Healthline: Obesity Facts Role of Physical Activity for Weight Loss and Weight Maintenance Acute and Chronic Effects of Exercise on Appetite, Energy Intake, and Appetite-Related Hormones: The Modulating Effect of Adiposity, Sex, and Habitual Physical Activity Dietary Approaches to the Treatment of Obesity Protein for Life: Review of Optimal Protein Intake, Sustainable Dietary Sources and the Effect on Appetite in Ageing Adults Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance Recent advances in understanding body weight homeostasis in humans Long-term weight loss maintenance Is there evidence for a set point that regulates human body weight? Obesity and Set-Point Theory Cell biology of fat storage Familial Adenomatous Polyposis Colorectal Cancer in African Americans: An Update

Ah, one of my favourite things to talk about - PMS Today on the podcast, I'm bringing y'all up to speed on the new research around how stress, food and movement affect your physical and mental state before your period.  Takeaways:  Perceived stress from the cycle before can make PMS in the following cycle worse Aerobic activity helps more with physical PMS symptoms, Yoga/Pilates helps more with mental PMS symptoms  A well balanced, unprocessed nutritional intake is best long term, but more research is definitely needed in this area Research Quoted:  A post-phenomenological analysis of using menstruation tracking apps for the management of premenstrual syndrome - 2022   Association of Premenstrual Syndrome with Adiposity and Nutrient Intake Among Young Indian Women - 2022   Associations of premenstrual symptoms with daily rumination and perceived stress and the moderating effects of mindfulness facets on symptom cyclicity in premenstrual syndrome - 2023   Evaluation of the effectiveness of yoga in management of premenstrual syndrome: a systematic review and meta-analysis - 2022   Exercise for premenstrual syndrome: a systematic review and meta-analysis of randomised controlled trials - 2020   Impact of nutritional diet therapy on premenstrual syndrome - 2023   Let's Be Friends! Leave a Review on Apple PodcastsLeave a Review on Spotify Full Shownotes Get On The Clinic Waitlist  Subscribe to The Superwoman Code Email List Follow @drashleymargeson on Instagram A Cornerstone Naturopathic Inc Production  

Tempo jedzenia może znacząco wpływać m.in. na nasycenie (sprzyjając lub utrudniając odchudzanie). Szybkość jedzenia jest uznawana za czynnik ryzyka otyłości. Ale to nie wszystko - element ten może zaskakująco wpływać na komfort jelitowy (będąc możliwą przyczyną np. wzdęć). Ale jak to w zasadzie interpretować i jak odnieść do praktyki? __

What are the details on the first nonpresciption contraceptive pill? Find out about this and more in today's PV Roundup podcast.

Ben discusses News Flashes, Book Reviews, and Answers Audience Questions. AI and heart health: AI Evaluation of Stenosis on Coronary CTA ...6:56 If you're concerned about heart health, a blood measurement called "plasma viscosity" is a good one to ask your physician about (in addition to a complete lipid panel, inflammatory markers, and glucose, IMO): Study link ...23:12 A simple strategy such as one baby aspirin a day is likely good for your heart, but also appears to be a “calorie restriction mimetic“, that can simulate the autophagy benefits of fasting. Anybody currently on the aspirin bandwagon? Any concerning side effects that you have experienced? Study link ...26:56 Easy hack for high triglycerides - 1-4g daily dose of ginger: Effect of Ginger... ...31:06 The hidden benefits of dick pills. Study link ...40:27 Statins aren't all bad, but more people are on them than likely need to be: Could This Widely Used Calculator Be Needlessly Driving People to Take Statins?...47:00 Sure, EXCESS fructose can make you fat, but not if you're NOT in caloric excess: Important Food Sources of Fructose-Containing Sugars and Adiposity (e.g. if you're burning 2000 calories per day you could drink 2000 calories of soda a day and not get fat provided you weren't eating or drinking anything else)...51:12 Sound advice here..."Eat like a pig" to lose weight: Eat like a Pig to Combat Obesity (cliff notes: don't overeat and optimize nutrient density)...56:13 If you're eating a low-carb diet, you sure as heck better be careful that it is very clean, rich in phytonutrients, and certainly not a dirty keto approach: Study link ...72:44 For the full show notes, visit: https://bengreenfieldlife.com/podcast/qa-458 Episode sponsors: Wild Health: Learn everything from your optimal diet, exercise, and sleep routines to understanding the risk of chronic illnesses and how to prevent them with their concierge program. Get 20% off with code BEN at wildhealth.com/ben. BON CHARGE: Products that can help you sleep better, perform better, recover faster, balance hormones, reduce inflammation, and so much more. Go to boncharge.com/GREENFIELD and use coupon code GREENFIELD to save 15%. Neurohacker Qualia Mind: Start experiencing what the best brain fuel on earth can do for YOUR mindset with Qualia Mind from Neurohacker. Go to neurohacker.com/ben for up to $100 off right now, and use code BGF at checkout for an extra 15% off. Organifi Sunrise: Organifi's Sunrise Kit includes their signature Green, Red, and Gold Juice blends. Get free shipping and 20% off your order of the Sunrise to Sunset Kit by going to organifi.com/ben. Big Bold Health: is offering 10% off your order. You can use this for Microbiome Rejuvenate, Himalayan Tartary Buckwheat Flour or any other single product. To claim your offer, head to BigBoldHealth.com and use code BEN10 for 10% off. Couples Collective: with your significant other in Napa, California October 25th - 29th. ownitcoaching.com/couples-collective to apply.See omnystudio.com/listener for privacy information.

This week Kate and Nancy discuss a paper detailing the negative effects that adiposity fat can have on the health and welfare of our horses. Research reference/link (open access): Pratt-Phillips, Shannon, and Ahmad Munjizun, (2023). "Impacts of Adiposity on Exercise Performance in Horses" Animals 13, no. 4 https://doi.org/10.3390/ani13040666 --- Send in a voice message: https://podcasters.spotify.com/pod/show/nancy-mclean/message Support this podcast: https://podcasters.spotify.com/pod/show/nancy-mclean/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.06.527292v1?rss=1 Authors: Perszyk, E. E., Davis, X. S., Djordjevic, J., Jones-Gotman, M., Trinh, J., Hutelin, Z., Veldhuizen, M. G., Koban, L., Wager, T. D., Kober, H., Small, D. M. Abstract: Mental imagery has been proposed to play a critical role in the amplification of cravings. Here we tested whether olfactory imagery drives food cue reactivity strength to promote adiposity in 45 healthy individuals. We measured odor perception, odor imagery ability, and food cue reactivity using self-report, perceptual testing, and neuroimaging. Adiposity was assessed at baseline and one year later. Brain responses to real and imagined odors were analyzed with univariate and multivariate decoding methods to identify pattern-based olfactory codes. We found that the accuracy of decoding imagined, but not real, odor quality correlated with a perceptual measure of odor imagery ability and with greater adiposity changes. This latter relationship was mediated by cue-potentiated craving and intake. Collectively, these findings establish odor imagery ability as a risk factor for weight gain and more specifically as a mechanism by which exposure to food cues promotes craving and overeating. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Gabrielle Lyon discusses protein requirements needed to maintain healthy muscle as you age and the latest research about muscle science. Sponsored: Support your Workout Sessions and Healthy Hydration with this Creatine Electrolyte Combo by MYOXCIENCE Save 15% with code podcast at MYOXCIENCE.com Link to Video and Show Notes: https://bit.ly/3XQrvxQ Key Takeaways: 0:00 Intro 2:20 Dietary protein and muscle are critical factors in longevity and ageing. 2:55 mTOR's purpose is growth promotion, not growth initiation. 5:15 Your ability to survive cancer is directly related to muscle. 10:50 Higher IGF-1 is linked with lower all-cause mortality. 14:15 RDA protein recommendation has not changed in 30 years. 15:30 Dr. Lyon recommends 1.6 grams/kilogram, or 1 gram per pound ideal body weight daily. 16:30 The capacity to store protein, other than amino acid reservoir in our muscles, does not exist. 18:10 You should not be doing fasting or protein restriction when you are in your 60s. 20:05 We have no consistent way to look at skeletal muscle. 22:05 A new equivalent for muscle mass has subjects ingest D3 creatine and measure the urinary output of creatinine. 22:30 Improvements in lean body mass do not necessarily correlate to improved or performance. 24:25 Mass of skeletal muscle does not indicate the quality of the tissue. 26:25 Adiposity is a symptom of impaired muscle. 27:55 Skeletal muscle accounts for 40% of your body. 28:40 Skeletal muscle insulin resistance can begin decades before symptoms. 30:25 Obese individuals have more muscle mass, but it says nothing about the quality of that muscle. 31:15 Irrespective of weight loss, exercise can improve triglycerides and HDL. 32:35 Muscle is an endocrine system. 36:45Muscle mass is more important in fracture risk than bone quality. 38:15 Loss of muscle is linked with accelerated degradation of bone. 40:25 Bloodwork should include heart and arteries. 43:45 There is benefit to cardio. 45:45 You need to lift weights. 48:30 Women build muscle mass at half the rate of men. 52:35 Dr. Lyon recommends supplemental creatine, vitamin D, fish oil, and urolithin A. 54:30 Vegans should take branch chain amino acids. 57:25 Your first meal of the day should contain between 30 to 50 grams of protein. 58:35 The minimum amount of protein needed to stimulate muscle protein synthesis is about 30 grams, optimally 50 grams. 01:00:25 We cannot eat our way out of climate change. 01:06:50 As children grow, a critical natural strength develops.

Marie og jeg er tilbage med føljetonen om de 5 spisetyper Marie har skrevet om i bogen "Spis efter din kvindetype". Denne gang skal det handle om sukkerspiseren, som på mange områder minder om kontrolspiseren. Men hvor kontrolspiseren kontrollerer de fleste af sine måltider, får sukkerspiseren fornuftige måltider dagen igennem, men oplever kontroltab især om eftermiddagen og aftenen i sukkerholdige fødevarer. Det kommer vi blandt andet ind på i episoden:• Hvad det vil sige, at være sukkerspiser.• Det at have et had/kærlighedsforhold til sukker.• Pendulering mellem slet ikke at spise sukker og at overspise i det.• Sukkerforskrækkelse.• Sukkermyter.• Hvordan du kan få et normaliseret forhold til sukker. • Frygten for at tage på ved at spise sukker.• Typiske årsager til overspisninger i sukkerholdige fødevarer.• Kokke-tricket.• Sensorisk sult.• Opmærksom spisning.• Om sukkertrang er et tegn på sult.• Hvordan sukker kan indgå i en sund og varieret kost. Sukker spiller ikke hovedrollen i udviklingen af overvægt, faktisk er det vist, at overvægtige spiser mindre sukker, end slanke (1).Pseudotilladelse (betinget tilladelse) til at spise tidligere forbudte fødevarer vil fortsat skabe overspisninger og en følelse af kontroltab (2).Når du giver dig selv ubetinget tilladelse til at spise hvad end du har lyst til, vil du eliminere behovet for at overspise (3).Det ser ud til at en "alt eller intet” mentalitet i forhold til kost, og overskridelse af egne kostregler, midlertidig kan føre til opgivelse af diæten (kontrollen) og overspisninger (4).1. J. J. Anderson et al (2017): Adiposity among 132 479 UK Biobank participants; contribution of sugar intake vs other macronutrients2: E. Tribole & E. Resch: Intuitive Eating - A revolutionary program that works, 86-87 (2012).3: E. Tribole & E. Resch: Intuitive Eating - A revolutionary program that works, 84 (2012).4. 2: A. Palascha et al.: Journal of Health Psychology2015 p. 638–648: How does thinking in Black and White terms relate to eating behavior and weight regain?

In this episode, Lexman interviews Mark Zuckerberg, the founder and CEO of Facebook. They discuss Zuckerburg's new book, "Stamen: A Story of Love, Sorrow, and Rediscovery." In it, Zuckerburg recounts his experiences after he was wrongly vilified in the public eye for the misuse of Facebook data.

Phew! There is so much to talk about here! We'll look at some physiology of how your hormones work, sex hormones, and practical applications to balance your hormones. As always, this is not medical advice. References: Thakur H, Pareek P, Sayyad MG, Otiv S. Association of Premenstrual Syndrome with Adiposity and Nutrient Intake Among Young Indian Women. Int J Womens Health. 2022 May 4;14:665-675. doi: 10.2147/IJWH.S359458. PMID: 35547840; PMCID: PMC9081175. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081175/ Pearce E, Jolly K, Jones LL, Matthewman G, Zanganeh M, Daley A. Exercise for premenstrual syndrome: a systematic review and meta-analysis of randomised controlled trials. BJGP Open. 2020 Aug 25;4(3):bjgpopen20X101032. doi: 10.3399/bjgpopen20X101032. PMID: 32522750; PMCID: PMC7465566. Brooks JD, Ward WE, Lewis JE, Hilditch J, Nickell L, Wong E, Thompson LU. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr. 2004 Feb;79(2):318-25. doi: 10.1093/ajcn/79.2.318. PMID: 14749240. https://pubmed.ncbi.nlm.nih.gov/14749240/ ​​ Roland AV, Moenter SM. Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: insight from animal models. Front Neuroendocrinol. 2014 Oct;35(4):494-511. doi: 10.1016/j.yfrne.2014.04.002. Epub 2014 Apr 18. PMID: 24747343; PMCID: PMC4175187. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175187/ --- Support this podcast: https://anchor.fm/liv-whisler/support

Obesity is a growing public health concern, but studies suggest that soluble fibre from certain cereal whole grains can help weight management. Rebecca Mathews and her collaborators in the US conducted a thorough review of key studies demonstrating the efficacy and mechanisms behind oat and barley β-glucan on weight loss. These findings confirm the importance of whole grains in combating obesity.Read the original article:   https://doi.org/10.1080/10408398.2021.1994523Find more in Research Outreach

In this episode, Dr. Scott and Tommy discuss fructose consumption, visceral adiposity index, can visceral adiposity index serve as a simple tool for identifying individuals with insulin resistance in daily clinical practice.   Show Transcript: www.thefastingforlife.com/blog   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of likeminded, new and experienced fasters! The first two rules of fasting need not apply! Come get questions answered on this week episode topic!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our FREE Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Maybe you are an experienced faster and wondering about your results and IF they could be linked to INSULIN resistance? Head over to the website and download our FREE Insulin Resistance Assessment!   Or get both here at our website:  www.thefastingforlife.com/resources   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it makes a difference in helping bring you the best original content each week. We also really enjoy reading them!   Sign up for the Fasting For Life newsletter at www.thefastingforlife.com   Follow Fasting For Life: www.facebook.com/thefastingforlife www.instagram.com/thefastingforlife   Join the Community on Facebook!   Reference Links:  Can Visceral Adiposity Index Serve as a Simple Tool for Identifying Individuals with Insulin Resistance in Daily Clinical Practice?   https://pubmed.ncbi.nlm.nih.gov/31470593/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845052/ Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance -  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151171   HOMA-IR Calculator https://www.omnicalculator.com/health/homa-ir   VAI Calculation   Females : VAI = (WC/36.58+(1.89xBMI)) x (TG/0.81) x (1.52/HDL)   Males : VAI = (WC/39.68+(1.88xBMI)) x (TG/1.03) X (1.31/HDL)

References Dr. Guerra's lipid lecture notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725. Progress in Lipid Research Volume 74, April 2019, Pages 145-159 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Listen in to my interview with Dr. Ali Zentner, Obesity Medicine Physician and Medical Director of the Revolution Medical Clinic in Vancouver. In this episode, we talk about: The history of obesity medicine in Canada The origins of weight bias and fat shaming The need to come up with new language around obesity, “adiposity”, “weight loss” What we can do to recognize our own bias Dr. Zentner is one of the pioneers in the field of Obesity Medicine in Canada and a strong voice for patient advocacy and ending fat-shaming. Dr. Zentner completed medical school at McMaster University, then Internal Medicine Residency with an extra year of Cardiology training at the University of Calgary. She is a Diplomat of the American Board of Obesity Medicine. Dr. Zentner founded the Southern Alberta Obesity Clinic in 2001. In 2004, she moved to Vancouver and established her own community based practice in West Vancouver focusing on obesity and cardiometabolic risk management. She has become a national leader in the field. In 2015, Dr. Zentner became the Medical Director of the Vancouver Island Bariatric Program and built the program into a multidisciplinary bariatric program which now supervises the bariatric surgeries of over 200 patients annually. After three years as director she moved on to establish a similar bariatric program within Fraser Health region. Dr. Zentner is the author of the book The Weight Loss Prescription: A Doctor's Guide to Permanent Weight Reduction and Better Health for Life. (Penguin Canada, 2013). Dr. Zentner is also an avid runner and triathlete. In 2011 she gave up her car and now commutes everywhere by bicycle or on foot. She can be seen walking the Arbutus Greenway every morning and evening on her way to and from work….. walking all the way. Check out the video of our conversation at https://youtu.be/6ZnAz6sE7BQ.

You don't need to lose weight to get out of pain. And the idea that some amount of pain is something we have to just “live with” because of our age or body type is nonsense. A majority of the messages in my inbox include some version of “I have pain and I know I need to lose weight but...” which honestly breaks my heart because I believe that life without pain is possible for everyone. I truly do. Researchers really want to make a connection between obesity, BMI, and pain but haven't been able to - but that doesn't stop them from trying. In this episode, you'll learn: Why you don't need to lose weight to get out of pain How science really wants to make a connection but can't And why focusing on BMI is a waste of time (and missing the point) All the links: Okifuji A, Hare BD. The association between chronic pain and obesity. J Pain Res. 2015;8:399-408. Published 2015 Jul 14. doi:10.2147/JPR.S55598 Evers Larsson, U. Influence of weight loss on pain, perceived disability and observed functional limitations in obese women. Int J Obes 28, 269–277 (2004). https://doi.org/10.1038/sj.ijo.0802534 McGoey BV, Deitel M, Saplys RJ, and Kliman ME. Effect of weight loss on musculoskeletal pain in the morbidly obese. The Journal of Bone and Joint Surgery. British volume 1990 72-B:2, 322-323 Paul Welsh, Eliana Polisecki, Michele Robertson, Sabine Jahn, Brendan M. Buckley, Anton J. M. de Craen, Ian Ford, J. Wouter Jukema, Peter W. Macfarlane, Chris J. Packard, David J. Stott, Rudi G. J. Westendorp, James Shepherd, Aroon D. Hingorani, George Davey Smith, Ernst Schaefer, Naveed Sattar, Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach, The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 1, 1 January 2010, Pages 93–99, https://doi.org/10.1210/jc.2009-1064 30 days to more strength + flexibility with the Mobility Mastery Toolkit Movement Mavens has the tools and strategy to support you on your path to enjoying life without pain - www.aewellness.com/mavens www.aewellness.com/podcast - Show notes, links and more. Join the free Body Nerds FB community: https://www.facebook.com/groups/aewbodynerds/ Come hang out with me on Instagram @hollaformala : https://instagram.com/hollaformala/ TikTok @ aewellness Bodywork Starter Guide - learn the 6 places you need to roll right now for quick-relief, plus the reason why what you've tried so far has only given you a temporary fix. Download the guide for free now at www.aewellness.com/bodywork 818-396-6501 is the Body Nerd Hotline - how do you build consistency and/or where are you getting stuck? Drop me a line and let me know your body nerd hacks - you might just hear your voice on a future episode! Today's episode was brought to you by The Amino Co. Their essential amino acid blends are 100% backed by science to help you perform at your best, heal from within, and live life to the fullest. Whether your goal is to reduce inflammation, maintain muscle mass or improve focus - the Amino Co has you covered! Save 30% off your entire order when you use the code BODYNERD at www.AEwellness.com/amino.

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This issue will review: Body Weight Changes During Pandemic-Related Shelter-in-Place Risk of Progression to Diabetes Among Older Adults with Prediabetes Cardiovascular, Renal, and Metabolic Outcomes of Dapagliflozin Versus Placebo in a Primary Cardiovascular Prevention Cohort: Analyses From DECLARE-TIMI 58 Diet quality and all-cause mortality Exposure to Gestational Diabetes Mellitus in utero and Daily Energy Intake, Brain Responses to Food Cues and Adiposity in Children Risk Type 2 Diabetes Subgroups, Risk for Complications, and Differential Effects Due to an Intensive Lifestyle Intervention   For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

FDA 批准MAPK激酶抑制剂治疗手术无法切除的1型神经纤维瘤BMJ 哮喘发作与空气污染和母亲孕期吸烟有关Nature Metabolism 母亲运动带来的后代的健康获益是通过母乳中的3′-唾液酸乳糖介导的司美替尼（selumetinib）神经纤维瘤是常染色体显性遗传病，分1、2和3型。1型神经纤维瘤最常见，标志性特征是多发的牛奶咖啡斑和相关皮肤神经纤维瘤。没有针对性的总体的治疗，只能对症治疗。50%的1型神经纤维瘤患者合并丛状神经纤维瘤，丛状神经纤维瘤是一种组织学上良性的周围神经鞘肿瘤，常累及多个神经束，造成毁容、运动功能障碍、疼痛、甚至脊髓受压。司美替尼是一种MAPK激酶的抑制剂，在2020年4月，FDA批准了司美替尼用于治疗1型神经纤维瘤。《司美替尼治疗不能手术的丛状神经纤维瘤患儿》New England Journal of Medicine，2020年4月 (1)这项开放标签的2期试验，旨在确定丛状神经纤维瘤患儿服用司美替尼后的临床益处和安全性。50名、平均年龄10.2岁的、不能手术的丛状神经纤维瘤的1型神经纤维瘤病患儿入组，随机接受了司美替尼和安慰剂治疗。最常见的神经纤维瘤相关症状包括毁容（44人）、运动功能障碍（33人）和疼痛（26人）。治疗后70%达到了部分缓解，56%≥1年的持久缓解。1年后，肿瘤疼痛评分平均降低了2分，疼痛对日常功能、总体健康相关生活质量、力量和关节活动范围等多项功能结局也观察到了有临床意义的改善。其中5人因副作用停药；6人疾病发展。最常见的毒性作用为恶心、呕吐或腹泻、无症状的肌酸磷酸激酶水平升高、痤疮样皮疹及甲沟炎。结论：对于手术无法切除的丛状神经纤维瘤患儿，司美替尼产生了持久的缩小肿瘤作用。儿童哮喘哮喘（asthma）是一种异质性疾病，特点是慢性气道炎症。12岁以下儿童哮喘是最常见的儿童期慢性疾病，约80%的患儿在5岁以前出现症状，咳嗽、哮鸣、呼吸急促、胸闷胸痛是常见的症状。最常见的诱发因素包括病毒性上呼吸道感染（合胞病毒、流感病毒、鼻病毒）、运动、天气、二手烟和变应原（如尘螨、宠物毛发、花粉、霉菌）。《病例队列研究：空气污染和家庭相关因素与儿童哮喘发作和持续性喘息的关系》BMJ，2020年8月(2)研究目的探讨儿童哮喘和持续性喘息发病的危险因素（空气污染和家庭相关因素）。这项全国病例对照研究中随访了1-15岁儿童儿童哮喘发病率升高，与父母患有哮喘（风险比 2.29）、母亲在怀孕期间吸烟（风险比 1.20）相关。儿童哮喘发病率低，与父母受教育程度高（风险比0.72）和父母收入高（风险比 0.85）相关。空气污染物PM2.5和PM10与哮喘的风险增加和持续喘息相关。结论：暴露于空气污染中的儿童更容易患哮喘和持续性喘息，哮喘与父母哮喘病史、父母教育程度和母亲在怀孕期间吸烟有关。《观察性研究：母亲在怀孕期间吸烟影响子女成年后哮喘发作》European Respiratory Journal 2020年7月 (3)研究的目的是确定产前哮喘和成人哮喘发病之间的关系。研究纳入5200名、1966年芬兰北部出生的、31岁前未诊断为哮喘的人群。研究发现孕妇妊娠最后3个月吸烟，其后代31岁至46岁之间哮喘累积发病率（男性为5.1%，女性为8.8%），尤其是与无哮喘病史（风险比9.63）或咳嗽喘息病史（风险比3.21）的后代中有显著相关性。同时在妊娠期吸烟与31岁时子代的用力呼气量（FEV1）/用力肺活量（FVC）比率之间有发现了显著的相关性，在在RUNX1单倍型rs11702779-AA的后代中成年期患哮喘的风险比为5.53。结论：怀孕期间吸烟与后代成年后哮喘累积发病率有关。《观察性研究：空气污染和从出生到成年的哮喘发展》European Respiratory Journal 2020年7月 (4)空气污染对青春期至成年期哮喘发展的影响尚不清楚，研究纳入了3687个参与者，评估空气污染和哮喘发生的年龄的相关关系。研究20岁之前哮喘的发病率，与出生地空气污染物的比例增加相关（接触PM10的风险比为1.09，接触NO2的风险比为1.20）。对近期家庭居住地的空气污染进行分析后，得到了类似的结果。结论：早年暴露在空气污染中，特别是来自机动交通的污染，与儿童、青春期到成年早期罹患哮喘的风险增加有关。《哮喘患儿卧室颗粒物过滤与气道病理生理变化的关系》JAMA Pediatrics，2020年8月 (5)细颗粒物PM2.5是一种普遍存在的空气污染物，可沉积在小气道中，对哮喘起着至关重要的作用。来自杜克大学与北京上海的研究人员合作，研究PM2.5过滤装置的使用是否能改善哮喘患儿的小气道生理学和呼吸系统炎症。研究人员在患儿的卧室里随机安装了真实的过滤设备和假的过滤设备，试验前有2周的洗脱期，研究是在臭氧含量低的季节在中国上海的郊区进行的。研究纳入轻中度哮喘的、共43个、5-13岁的儿童参加了研究。室外PM2.5浓度中度升高（28.6-69.8μg/m3)；经过滤的卧室PM2.5浓度比不经过滤降低63.4%。过滤的卧室空气能显著改善气道力学，总气道阻力下降24.4%，减少小气道阻力43.5%，呼气流量峰值也显著改善。这些改善与卧室PM2.5的减少显著相关。总体的小气道功能改善均没有统计学意义，但在不伴有嗜酸性气道炎症的参与者中改善显著（13.2%）。结论：室内PM2.5过滤可以通过改善气道力学和功能，减少炎症，改善哮喘患者肺部的气体流动。《VDKA研究：补充维生素D3对低维生素D和哮喘患儿哮喘加重的影响》JAMA，2020年8月 (6)研究的目的探讨维生素D3的补充是否能改善儿童哮喘和低维生素D水平严重恶化的时间。这项随机、双盲、安慰剂对照临床试验，纳入6-16岁的、哮喘严重发作高危儿童共192人，平均年龄9.8岁，女孩40%维生素D3组的37.5%和安慰剂组的34.4%出现≥1次严重恶化。补充维生素D3并没有显著改善哮喘严重恶化的时间，没有显著改善病毒诱导哮喘严重加重的时间，没有显著改善糖皮质激素剂量减量的患者比例，也没有显著减少糖皮质激素的累积剂量。两组严重不良事件相似。结论：该研究不支持在持续性哮喘和低维生素D水平的儿童维生素D3来预防哮喘加重。《前瞻性队列研究：抗生素的使用减少，影响肠道菌群和儿童哮喘发病率》Lancet Respiratory Medicine，2020年7月 (7)在欧洲和北美的一些地区，儿童哮喘的发病率正在下降；有研究提示婴儿期使用抗生素与哮喘风险增加有关。该研究的目的是验证哮喘发病率的降低是否与抗生素处方减少有关，并验证这种变化是由肠道菌群变化介导的。本研究包括基于人群和前瞻性队列分析，使用加拿大不列颠哥伦比亚省（人口400万·700万）每年抗生素处方率和哮喘诊断率的管理数据进行人群分析。2000 - 2014年，1-4岁儿童的哮喘发病率从27·3‰ 下降到20·2‰，降幅26·0%。发病率的降低与

FDA 批准MAPK激酶抑制剂治疗手术无法切除的1型神经纤维瘤BMJ 哮喘发作与空气污染和母亲孕期吸烟有关Nature Metabolism 母亲运动带来的后代的健康获益是通过母乳中的3′-唾液酸乳糖介导的司美替尼（selumetinib）神经纤维瘤是常染色体显性遗传病，分1、2和3型。1型神经纤维瘤最常见，标志性特征是多发的牛奶咖啡斑和相关皮肤神经纤维瘤。没有针对性的总体的治疗，只能对症治疗。50%的1型神经纤维瘤患者合并丛状神经纤维瘤，丛状神经纤维瘤是一种组织学上良性的周围神经鞘肿瘤，常累及多个神经束，造成毁容、运动功能障碍、疼痛、甚至脊髓受压。司美替尼是一种MAPK激酶的抑制剂，在2020年4月，FDA批准了司美替尼用于治疗1型神经纤维瘤。《司美替尼治疗不能手术的丛状神经纤维瘤患儿》New England Journal of Medicine，2020年4月 (1)这项开放标签的2期试验，旨在确定丛状神经纤维瘤患儿服用司美替尼后的临床益处和安全性。50名、平均年龄10.2岁的、不能手术的丛状神经纤维瘤的1型神经纤维瘤病患儿入组，随机接受了司美替尼和安慰剂治疗。最常见的神经纤维瘤相关症状包括毁容（44人）、运动功能障碍（33人）和疼痛（26人）。治疗后70%达到了部分缓解，56%≥1年的持久缓解。1年后，肿瘤疼痛评分平均降低了2分，疼痛对日常功能、总体健康相关生活质量、力量和关节活动范围等多项功能结局也观察到了有临床意义的改善。其中5人因副作用停药；6人疾病发展。最常见的毒性作用为恶心、呕吐或腹泻、无症状的肌酸磷酸激酶水平升高、痤疮样皮疹及甲沟炎。结论：对于手术无法切除的丛状神经纤维瘤患儿，司美替尼产生了持久的缩小肿瘤作用。儿童哮喘哮喘（asthma）是一种异质性疾病，特点是慢性气道炎症。12岁以下儿童哮喘是最常见的儿童期慢性疾病，约80%的患儿在5岁以前出现症状，咳嗽、哮鸣、呼吸急促、胸闷胸痛是常见的症状。最常见的诱发因素包括病毒性上呼吸道感染（合胞病毒、流感病毒、鼻病毒）、运动、天气、二手烟和变应原（如尘螨、宠物毛发、花粉、霉菌）。《病例队列研究：空气污染和家庭相关因素与儿童哮喘发作和持续性喘息的关系》BMJ，2020年8月(2)研究目的探讨儿童哮喘和持续性喘息发病的危险因素（空气污染和家庭相关因素）。这项全国病例对照研究中随访了1-15岁儿童儿童哮喘发病率升高，与父母患有哮喘（风险比 2.29）、母亲在怀孕期间吸烟（风险比 1.20）相关。儿童哮喘发病率低，与父母受教育程度高（风险比0.72）和父母收入高（风险比 0.85）相关。空气污染物PM2.5和PM10与哮喘的风险增加和持续喘息相关。结论：暴露于空气污染中的儿童更容易患哮喘和持续性喘息，哮喘与父母哮喘病史、父母教育程度和母亲在怀孕期间吸烟有关。《观察性研究：母亲在怀孕期间吸烟影响子女成年后哮喘发作》European Respiratory Journal 2020年7月 (3)研究的目的是确定产前哮喘和成人哮喘发病之间的关系。研究纳入5200名、1966年芬兰北部出生的、31岁前未诊断为哮喘的人群。研究发现孕妇妊娠最后3个月吸烟，其后代31岁至46岁之间哮喘累积发病率（男性为5.1%，女性为8.8%），尤其是与无哮喘病史（风险比9.63）或咳嗽喘息病史（风险比3.21）的后代中有显著相关性。同时在妊娠期吸烟与31岁时子代的用力呼气量（FEV1）/用力肺活量（FVC）比率之间有发现了显著的相关性，在在RUNX1单倍型rs11702779-AA的后代中成年期患哮喘的风险比为5.53。结论：怀孕期间吸烟与后代成年后哮喘累积发病率有关。《观察性研究：空气污染和从出生到成年的哮喘发展》European Respiratory Journal 2020年7月 (4)空气污染对青春期至成年期哮喘发展的影响尚不清楚，研究纳入了3687个参与者，评估空气污染和哮喘发生的年龄的相关关系。研究20岁之前哮喘的发病率，与出生地空气污染物的比例增加相关（接触PM10的风险比为1.09，接触NO2的风险比为1.20）。对近期家庭居住地的空气污染进行分析后，得到了类似的结果。结论：早年暴露在空气污染中，特别是来自机动交通的污染，与儿童、青春期到成年早期罹患哮喘的风险增加有关。《哮喘患儿卧室颗粒物过滤与气道病理生理变化的关系》JAMA Pediatrics，2020年8月 (5)细颗粒物PM2.5是一种普遍存在的空气污染物，可沉积在小气道中，对哮喘起着至关重要的作用。来自杜克大学与北京上海的研究人员合作，研究PM2.5过滤装置的使用是否能改善哮喘患儿的小气道生理学和呼吸系统炎症。研究人员在患儿的卧室里随机安装了真实的过滤设备和假的过滤设备，试验前有2周的洗脱期，研究是在臭氧含量低的季节在中国上海的郊区进行的。研究纳入轻中度哮喘的、共43个、5-13岁的儿童参加了研究。室外PM2.5浓度中度升高（28.6-69.8μg/m3)；经过滤的卧室PM2.5浓度比不经过滤降低63.4%。过滤的卧室空气能显著改善气道力学，总气道阻力下降24.4%，减少小气道阻力43.5%，呼气流量峰值也显著改善。这些改善与卧室PM2.5的减少显著相关。总体的小气道功能改善均没有统计学意义，但在不伴有嗜酸性气道炎症的参与者中改善显著（13.2%）。结论：室内PM2.5过滤可以通过改善气道力学和功能，减少炎症，改善哮喘患者肺部的气体流动。《VDKA研究：补充维生素D3对低维生素D和哮喘患儿哮喘加重的影响》JAMA，2020年8月 (6)研究的目的探讨维生素D3的补充是否能改善儿童哮喘和低维生素D水平严重恶化的时间。这项随机、双盲、安慰剂对照临床试验，纳入6-16岁的、哮喘严重发作高危儿童共192人，平均年龄9.8岁，女孩40%维生素D3组的37.5%和安慰剂组的34.4%出现≥1次严重恶化。补充维生素D3并没有显著改善哮喘严重恶化的时间，没有显著改善病毒诱导哮喘严重加重的时间，没有显著改善糖皮质激素剂量减量的患者比例，也没有显著减少糖皮质激素的累积剂量。两组严重不良事件相似。结论：该研究不支持在持续性哮喘和低维生素D水平的儿童维生素D3来预防哮喘加重。《前瞻性队列研究：抗生素的使用减少，影响肠道菌群和儿童哮喘发病率》Lancet Respiratory Medicine，2020年7月 (7)在欧洲和北美的一些地区，儿童哮喘的发病率正在下降；有研究提示婴儿期使用抗生素与哮喘风险增加有关。该研究的目的是验证哮喘发病率的降低是否与抗生素处方减少有关，并验证这种变化是由肠道菌群变化介导的。本研究包括基于人群和前瞻性队列分析，使用加拿大不列颠哥伦比亚省（人口400万·700万）每年抗生素处方率和哮喘诊断率的管理数据进行人群分析。2000 - 2014年，1-4岁儿童的哮喘发病率从27·3‰ 下降到20·2‰，降幅26·0%。发病率的降低与

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.26.174086v1?rss=1 Authors: Morys, F., Dadar, M., Dagher, A. Abstract: Chronic obesity is associated with several complications, including cognitive impairment and dementia. However, we have piecemeal knowledge of the mechanisms linking obesity to central nervous system damage. Adiposity leads to the metabolic syndrome, consisting of inflammation, hypertension, dyslipidemia and insulin resistance. In turn, these metabolic abnormalities cause cerebrovascular dysfunction, which may cause white and grey matter tissue loss and consequent cognitive impairment. While there have been several neuroimaging studies linking adiposity to changes in brain morphometry, a comprehensive investigation of the relationship has so far not been done. Here we use structural equation modelling applied to over 14,000 individuals from the UK Biobank to identify the causal chain that links adiposity to cognitive dysfunction. We found that body mass index and waist-to-hip ratio were positively related to higher plasma C-reactive protein, dyslipidemia, occurrence of hypertension and diabetes, all of which were in turn related to cerebrovascular disease as measured by volume of white matter hyperintensities on magnetic resonance imaging. White mater hyperintensities were associated with lower cortical thickness and volume and higher subcortical volumes, which were associated with cognitive deficits on tests of visuospatial memory, fluid intelligence, and working memory among others. In follow-up analyses we found that inflammation, hypertension and diabetes mediated 20% of the relationship between obesity and cerebrovascular disease and that cerebrovascular disease mediated a significant proportion of the relationship between obesity and cortical thickness and volume. We also showed that volume of white matter hyperintensities was related to decreased fractional anisotropy and increased mean diffusivity in the majority of white matter tracts, pointing to white matter dysconnectivity as a major cause of impaired cognition. Our results have clinical implications, supporting a role for the management of adiposity in the prevention of late-life dementia and cognitive decline. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.25.172379v1?rss=1 Authors: Moura-Assis, A., de Lima-Junior, J. C., Nogueira, P. A., Simabuco, F. M., Gaspar, J. M., Junior, J. D., Velloso, L. A. Abstract: In a public dataset of transcripts differentially expressed in selected neuronal subpopulations of the arcuate nucleus, we identified TLR4-interactor with leucine-rich repeats (Tril) as a potential candidate for mediating the harmful effects of a high-fat diet in proopiomelanocortin (POMC) neurons. The non-cell-specific inhibition of Tril in the arcuate nucleus resulted in reduced hypothalamic inflammation, protection against diet-induced obesity associated with increased whole-body energy expenditure and increased systemic glucose tolerance. The inhibition of Tril, specifically in POMC neurons, resulted in a trend for protection against diet-induced obesity, increased energy expenditure and increased hypothalamic sensitivity to leptin. Thus, Tril emerges as a new component of the complex mechanisms that promote hypothalamic dysfunction in experimental diet-induced obesity. Copy rights belong to original authors. Visit the link for more info

This is the first episode in our series on aging. In this episode the panel and I discuss a recent paper out of Ball State's Human Performance lab entitled "Skeletal Muscle Size, Function and Adiposity with Life Long Aerobic Exercise". (doi:10.1152/japplphysiol.00426.2019)  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.10.087619v1?rss=1 Authors: Voigt, K., Razi, A., Harding, I. H., Andrews, Z. B., Verdejo-Garcia, A. Abstract: Obesity has been ascribed to corticostriatal regions taking control over homeostatic areas. To test this assumption, we applied an effective connectivity approach to reveal the direction of information flow between brain regions and the valence of connections (excitatory versus inhibitory) as a function of adiposity and homeostatic state. Forty-one participants (21 overweight/obese) underwent two resting-state fMRI scans: after overnight fasting (hunger) and following a standardised meal (satiety). We used spectral dynamic causal modelling to unravel hunger and adiposity related changes in directed connectivity between cortical, insular, striatal and hypothalamic regions. During hunger, as compared to satiety, we found increased excitation of the ventromedial prefrontal cortex over the ventral striatum and hypothalamus, suggesting enhanced top-down modulation compensating energy depletion. Adiposity was associated with increased excitation of the anterior insula over the hypothalamus across the hunger and satiety conditions. The interaction of hunger and adiposity yielded decreased intra-cortical excitation from the dorsolateral to the ventromedial prefrontal cortex. Our findings suggest that obesity is associated with persistent top-down excitation of the hypothalamus, regardless of homeostatic state, and hunger-related reductions of dorsolateral to ventromedial prefrontal inputs. These findings are compatible with eating without hunger and reduced self-regulation views of obesity. Copy rights belong to original authors. Visit the link for more info

Commentary by Dr. Valentin Fuster

Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system.   The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for “qualifying round,” which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., “fast”), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: https://peterattiamd.com/podcast/qualys/   Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/  Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD 

Chris and Cara chat with Dr. NIcky Hawley, an assistant professor of anthropology and epidemiology at Yale School of Medicine. Dr. Hawley's work focuses on the intergenerational transmission of chronic disease in Samoa, American Samoa, and South Africa. In this episode, she chats with Chris and Cara about her work with the Genome-Wide Association Study of Adiposity in Samoa. Her interview sheds light on ethical considerations and the possibilities of political and community engagement within the sciences. To contact Dr. Hawley, check out her website with Yale https://medicine.yale.edu/profile/nicola_hawley/ or her page with the OLAGA Samoan study group at https://publichealth.yale.edu/olaga/ or on facebook at https://www.facebook.com/YaleOlaga/. The Sausage of Science is produced by Cara Ocobock and Chris Lynn, with assistance from Junior Service Fellow Caroline Owens for the Public Relations Committee of the Human Biology Association. The song in the soundbed is “Always Lyin’” by the Morning Shakes. Contact the Sausage of Science and Human Biology Association: Facebook: www.facebook.com/groups/humanbiologyassociation Website:humbio.org/, Twitter: @HumBioAssoc Michaela Howells, Public Relations Committee Chair, Email: howellsm@uncw.edu Cara Ocobock, Website: sites.nd.edu/cara-ocobock/, Email:cocobock@nd.edu, Twitter:@CaraOcobock Chris Lynn, Website:cdlynn.people.ua.edu/, Email:cdlynn@ua.edu, Twitter:@Chris_Ly Caroline Owens, Email: cowens8@emory.edu, Twitter: @careowens

Recently a new documentary came out on Netflix. It's called "The Game Changers" and it advocates for a plant-based diet as being optimal for health, performance, longevity, and moreover, claiming that eating meat raises inflammation and causes cancer.There were plenty of research studies cited, but are they valid? In this episode I breakdown how misleading the claims are, how they misrepresent science, and explain why and how many can see a benefit in switching to a plant-based diet. I also talk about:• Differences between randomized controlled trials and epidemiology and why it matters• Why athletes and people in general feel better switching diets• Why being dogmatic is stifling us and how to prevent that• Were the Gladiators Plant-based?• The REAL cause of inflammation• Omega 3 to Omega 6 ratio, and why too many omega 6’s can be problematic• m-TORC and IGF-1• Elevated homocysteine levels with b12 deficiencies • Why heme-iron shouldnt be demonizedAnd much more. Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studieshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273353/pdf/bjc2011585a.pdfRed and processed meat consumption and risk of stroke: a meta-analysis of prospective cohort studieshttps://www.nature.com/articles/ejcn2012180Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Studyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540319/Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes. https://www.ncbi.nlm.nih.gov/pubmed/27765690 Increased Lean Red Meat Intake Does Not Elevate Markers of Oxidative Stress and Inflammation in Humans https://academic.oup.com/jn/article/137/2/363/4664544Newly Revised Guidelines for Meat Consumption NOT BASED ON EPIDEMIOLOGYhttps://annals.org/aim/fullarticle/2752328/unprocessed-red-meat-processed-meat-consumption-dietary-guideline-recommendations-fromDietary habits and mortality in 11,000 vegetarians and health conscious people: results of a 17 year follow up.https://www.ncbi.nlm.nih.gov/pubmed/884206845 and up study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557061/https://www.who.int/gho/countries/en/Check out my blog post for full written analysis and the rest of the studies.www.eclecticathlete.comTwitter | julesofenergyInstagram | julesofenergyFacebook | eclecticathleteSupport the show (https://www.patreon.com/eclecticathlete)

Background: The energy content of whole, fresh fruit derives primarily from simple sugars, which are currently under heightened scrutiny for their potential contribution to obesity and chronic disease risk. Yet fruit also has a relatively low energy density, moderate palatability/reward value, and high fiber content, which together may limit energy intake. Although reasoned arguments can be made that fruit is fattening or slimming, the question is best resolved empirically. Methods: Methods were preregistered with PROSPERO (CRD42018111830). The primary outcome is the impact of whole, fresh fruit consumption on measures of adiposity including body weight in randomized controlled trials (RCTs). Secondary outcomes are the impact of whole, fresh fruit consumption on energy intake in RCTs, and the association between whole, fresh fruit consumption and changes in measures of adiposity in prospective observational studies. CENTRAL and PubMed databases were searched through October 2018. Cochrane risk of bias tool was used to assess risk of bias in RCTs, and the GRADE method was used to judge and convey the certainty of conclusions. Reporting follows PRISMA guidelines. Results: RCTs, and particularly those of higher quality, suggest that increasing whole, fresh fruit consumption promotes weight maintenance or modest weight loss over periods of 3–24 weeks (moderate certainty), with limited evidence suggesting that a high intake of fruit favors weight loss among people with overweight or obesity. Consistent with this, single-meal RCTs suggest that consuming whole, fresh fruit tends to decrease energy intake, particularly when consumed prior to a meal or when displacing more energy-dense foods (moderate certainty). Prospective observational studies suggest that habitually higher fruit intake is not associated with weight change, or is associated with modest protection against weight gain, over five or more years. Conclusions: Current evidence suggests that whole, fresh fruit consumption is unlikely to contribute to excess energy intake and adiposity, but rather has little effect on these outcomes or constrains them modestly. Single-meal RCTs, RCTs lasting 3–24 weeks, and long-term observational studies are relatively consistent in supporting this conclusion. Whole, fresh fruit probably does not contribute to obesity and may have a place in the prevention and management of excess adiposity. Guyenet SJ. Impact of Whole, Fresh Fruit Consumption on Energy Intake and Adiposity: A Systematic Review. Front Nutr. 2019;6:66. Published 2019 May 8. doi:10.3389/fnut.2019.00066 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Sections of the Abstract, Introduction, and Conclusion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518666/

Today’s episode is a conversation with Assistant Professor Andres Cardenas from the University of California, Berkeley. Dr Cardenas has been the lead author of two PFAS studies but the focus of today’s conversation is his research published in 2018.The objective of the study was to determine the extent to which PFASs are associated with increases in weight and body size and evaluate whether a lifestyle intervention modifies this association.“We found that PFASs measured in blood are associated with weight gain. However we see that exercise and diet, so this is a lifestyle intervention of exercise and diet was able to attenuate this weight gain, that is associated with this PFAS exposure.”The importance of Dr Cardenas’s research is because PFASs are chemicals that are suspected endocrine disruptors.Show Notes: Episode 111. Research Paper Cardenas et al Published 2/10/2017 in Environmental Health Perspectives: “Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial.” https://doi.org/10.1289/EHP16122. Research Paper Cardenas et al Published August 31, 2018 in JAMA Network Open: “Association of Perfluoroalkyl Substances with Adiposity.” 10.1001/jamanetworkopen.2018.14933. Research Paper (Dr Cardenas referred to in the show by colleagues whofound similar PFAS & weight gain associations) https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002502

Greg Potter PhD is a researcher and content director at HumanOS.me, an online platform helping people lead healthier lives. Greg’s thought-provoking research explores the associations between sleep duration, diet, physical activity and metabolic health. This podcast highlights the vital role sleep plays in health and the social influences that impact our sleep-wake cycle.

Greg Potter PhD is a researcher and content director at HumanOS.me, an online platform helping people lead healthier lives. Greg’s thought-provoking research explores the associations between sleep duration, diet, physical activity and metabolic health. This podcast highlights the vital role sleep plays in health and the social influences that impact our sleep-wake cycle.

A preexperimental cohort study was conducted with 67 overweight cancer survivors. This cohort of participants was screened for baseline body composition and anthropometrics based on a variety of techniques, including body mass index (BMI), dual X-ray absorptiometry–percentage body fat (DXA-android %BF), diagnostic medical sonography (DMS), and waist circumference (WC). The combination of subcutaneous fat layer at the xyphoid and umbilicus compared with BMI, WC, and DXA-android %BF. These variables demonstrated moderately positive association and were statistically significant. A total maximum mean score of DMS measures of subcutaneous and visceral fat was also compared with BMI, WC, and DXA-android %BF. The aforementioned comparison had a moderately positive association and was statistically significant. The sonographic measure of mesentery fat was compared with WC and demonstrated a strongly positive strength of association and was statistically significant. Sonography may be an inexpensive, noninvasive, portable, and valid body composition measure for overweight patients.

In the July/August 2018 JDMS podcast, Associate Editor Sharlette Anderson and author Nicole Stigall discuss her article "Abdominal Adiposity Measured by Sonography as a Tool for Determining Disease Risk." To view this article, click here.

Clinical Measures of Adiposity Risk for Predicting Obesity in Adolescents w/Physical Disabilities by Physiatry News

I've been reading a lot of books this year, and in this week's vlog, I talk about the book I'm currently consuming because one of the chapters completely blew my mind. I think it's going to blow yours, too. This … The post The Adiposity Set Point appeared first on Bright Line Eating®.

Commentary by Dr. David Wilber

Episode 74: Evelyn Kocur talks carbohydrates, insulin and adiposity.

On this week's show we cover some contentious topics including the recently released Bulletproof Diet; the archaeological view of Paleo diets; and weight gain. We discuss the continuing evolution of my diet as my weight drops into the 160s. Also, we take a brief look at a new Paleo TV show in Australia. The Moment of Paleo is my best sales pitch juxtaposed against high octane brains and upgraded marketing. After the Bell, it's Denise Minger who says Paleo can learn from the Vegans. Links for this episode:Chef Pete EvansThe Paleo Way - Watch full episodes - PLUS7 - Yahoo!7PLOS Medicine: Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight ChangeWeight Gain Carries Risks, No Matter Your Weight - NYTimes.comObesity Could Cut Life Expectancy By Almost A Decade (VIDEO)Obesity-Related Ills May Shave Up to 8 Years Off Your Life: Study – WebMDBMI may not be the last word on health risks, some experts say - LA TimesThe Archaeology News Network: What was the 'Paleo diet'? There was far more than one, study suggestsThere Was No 'Paleo Diet' - Ancient People Ate What They HadBlood, bulbs, and bunodonts: on evolutionary ecology and the diets ... - PubMed - NCBIHunter-gatherer diets—a different perspectiveList of vegetables - Wikipedia, the free encyclopediaThe Bulletproof Diet: simplistic, invalid and unscientific - TelegraphThe Bulletproof Diet is everything wrong with eating in America - VoxWhy putting butter in your coffee is a big, steaming cup of ‘bulletproof’ nonsenseScoop of butter for your coffee? ‘Fat black’ fad is either ‘bio-hack’ or disgusting trend, but no one’s quite sure | National Postbulletproof diet pdf - Google Search2014-03AnnalsofIntMedChowdhuryetalFatandCHD+responses.pdf'Bulletproof' Coffee May Hike Lipids | Medpage TodayNathan Pritikin - YouTubeLessons From the Vegans — Denise Minger (AHS14) - YouTube Purakai.com - Shop for Organic Clothing from PuraKai - Use coupon code "latest in paleo" for free shipping!

Commentary by Dr. Valentin Fuster

Pathik D. Wadhwa, MD, PhD. Professor of Psychiatry & Human Behavior, Obstetrics & Gynecology, Pediatrics, and Epidemiology; Director, UC Irvine Development, Health and Disease Research Program -University of California, Irvine, School of Medicine Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 28516]

Pathik D. Wadhwa, MD, PhD. Professor of Psychiatry & Human Behavior, Obstetrics & Gynecology, Pediatrics, and Epidemiology; Director, UC Irvine Development, Health and Disease Research Program -University of California, Irvine, School of Medicine Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Professional Medical Education] [Show ID: 28516]

Pathik D. Wadhwa, MD, PhD. Professor of Psychiatry & Human Behavior, Obstetrics & Gynecology, Pediatrics, and Epidemiology; Director, UC Irvine Development, Health and Disease Research Program -University of California, Irvine, School of Medicine Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 28516]

Pathik D. Wadhwa, MD, PhD. Professor of Psychiatry & Human Behavior, Obstetrics & Gynecology, Pediatrics, and Epidemiology; Director, UC Irvine Development, Health and Disease Research Program -University of California, Irvine, School of Medicine Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 28516]

Pathik D. Wadhwa, MD, PhD. Professor of Psychiatry & Human Behavior, Obstetrics & Gynecology, Pediatrics, and Epidemiology; Director, UC Irvine Development, Health and Disease Research Program -University of California, Irvine, School of Medicine Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 28516]

Pathik D. Wadhwa, MD, PhD. Professor of Psychiatry & Human Behavior, Obstetrics & Gynecology, Pediatrics, and Epidemiology; Director, UC Irvine Development, Health and Disease Research Program -University of California, Irvine, School of Medicine Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 28516]

David Allison, PhD, University of Alabama at Birmingham

Host: Alan S. Brown, MD, FNLA Dr. Harold Bays, Chair for the National Lipid Association's expert panel on Adiposity, Obesity, and Dyslipidemia, discusses with host Dr. Alan Brown the panel's consensus statement published in the Journal of Clinical Lipidology.

Adiposity and masculinity, food restriction, mercury in fish, frozen vs. fresh broccoli, green space, long walks, party eating, and dark room sleeping

This report provides a summary of a workshop organised by the EuropeanCommission-funded EarlyNutrition Project and the EarlyNutrition Academy.Accurate and reliable methods to assess body composition are needed inresearch on prenatal and early post-natal influences of nutrition onlater health because common surrogate measures of maternal and offspringadiposity (body fat content), such as body mass index (BMI), haverelatively poor predictive power for the risk of later disease. The keygoals of the workshop were to discuss approaches to assess growth andbody composition from pregnancy to adolescence, to summarise conclusionsand to prepare a framework for research in the EarlyNutrition Project.The participants concluded that there is a pressing need to harmonisethe methodologies for assessing body composition, recognising that eachhas advantages and limitations. Essential core measurements acrossstudies assessing early growth and body composition were identified,including weight, length, BMI, waist and mid-upper arm circumference,subscapular and triceps skinfold thicknesses, and bioelectricalimpedance analysis. In research settings with access to moresophisticated technologies, additional methods could include dual-energyX-ray absorptiometry, peripheral quantitative computed tomography,ultrasound assessment of regional body fat, magnetic resonance imaging(MRI), air displacement plethysmography (ADP), and deuterium dilution.These provide richer data to answer research questions in greater depthbut also increase costs. Where overall whole-body composition is theprimary outcome measure, ADP or tracer dilution should be used wheneverpossible. Where regional distribution of body fat is of greaterinterest, an imaging technique such as MRI is preferred.

Offspring of obese and diabetic mothers are at increased risk of beingborn with excess adiposity as a consequence of their intrauterineenvironment. Excessive fetal fat accretion reflects additional placentalnutrient transfer, suggesting an effect of the maternal environment onplacental function. High plasma levels of particular nutrients in obeseand diabetic mothers are likely to be the important drivers of nutrienttransfer to the fetus, resulting in excess fat accretion. However, notall offspring of obese and diabetic mothers are born large forgestational age and the explanation may involve the regulation ofplacental nutrient transfer required for fetal growth. The placentaintegrates maternal and fetal signals across gestation in order todetermine nutrient transfer rate. Understanding the nature of thesesignals and placental responses to them is key to understanding thepathology of both fetal growth restriction and macrosomia. The overalleffects of the maternal environment on the placenta are the product ofits exposures throughout gestation, the ‘placental exposome’.Understanding these environmental influences is important as exposuresearly in gestation, for instance causing changes in the function ofgenes involved in nutrient transfer, may determine how the placenta willrespond to exposures later in gestation, such as to raised maternalplasma glucose or lipid concentrations. Longitudinal studies arerequired which allow investigation of the influences on the placentaacross gestation. These studies need to make full use of developingtechnologies characterising placental function, fetal growth and bodycomposition. Understanding these processes will assist in thedevelopment of preventive strategies and treatments to optimise prenatalgrowth in those pregnancies at risk of either excess or insufficientnutrient supply and could also reduce the risk of chronic disease inlater life.

Learn How Juice Concentrates Increasing Carotene Levels Reduce Obesity and Improve Insulin Resistance Kirk Hamilton interviews Dr. Atilio Canas, MD, an Assistant Professor of Pediatrics at the Mayo Medical School, from the Department of Pediatric Endocrinology, Diabetes and Metabolism, Nemours Children's Clinic, in Jacksonville, FL. He is co-author the article entitled, "Insulin Resistance and Adiposity in Relation to Serum β-Carotene Levels," in the Journal Pediatr, in February of 2012. Download or Open:  

University of South Carolina