Podcasts about endothelial function

Spring is the perfect time to shake up your routine. In this episode, Professor Tim Spector and Dr. Federica Amati reveal seven delicious, science-backed foods that help cool the flame of chronic inflammation. Whether you're dealing with bloating, aching joints, or low energy, this episode is packed with easy, gut-friendly tips to help you feel your best this season. Tim and Federica begin by explaining what inflammation really is and when it becomes a problem. Then, they'll introduce seven anti-inflammatory foods that are as powerful as they are delicious. From cruciferous vegetables to fermented surprises, these everyday ingredients can help you build a more resilient, healing diet.  Finally, they offer a roadmap for long-term change. Tim and Fed each share one small but powerful shift to reduce inflammation over four timelines - what you can do today, this week, this month, and throughout the year - to create habits that truly stick.

Broadcast from KSQD, Santa Cruz on 4-10-2025: Dr. Dawn responds to an email about difficult-to-control asthma, recommending quercetin and inhaled cromolyn as mast cell stabilizers, and suggesting Montelukast to address leukotrienes while investigating possible mold exposure as an underlying cause. She discusses groundbreaking research on age-related bone deterioration, explaining how osteocytes undergo structural changes with age, and exploring the concept of cellular senescence including potential treatments like quercetin/dasatinib combination therapy, fisetin, and metformin. A frequent caller with a history of sepsis, osteomyelitis and eye infections describes newly developed high blood pressure, with Dr. Dawn explaining how oxidative stress from infection can damage endothelial cells, reducing nitric oxide production and suggesting L-arginine, beet consumption, and proper blood pressure measurement techniques. Responding to an email about preventing cartilage loss, Dr. Dawn evaluates glucosamine sulfate research, noting key differences between effective and ineffective studies, while emphasizing the importance of achieving healthy body weight as a primary factor in preventing osteoarthritis progression. Dr. Dawn provides guidance to an email question about choosing a primary care physician before retirement, recommending selecting doctors established in their practice for 3-4 years and warning against Medicare Advantage plans that limit provider options. She addresses an email from someone experiencing persistent fatigue following Epstein-Barr virus reactivation, suggesting additional testing to confirm viral load through PCR rather than relying solely on antibody levels, while exploring alternative causes including long COVID, mold exposure, or autoimmune issues.

Dr. Caldwell B. Esselstyn, Jr. explores effective strategies to end the cardiovascular disease epidemic. Learn how lifestyle changes and preventive measures can significantly reduce heart disease risk. #CardiovascularHealth #HeartDiseasePrevention #HealthRevolution

Join Dr. Columbus Batiste as he shares the principles of being SELFISH for heart health. Learn how prioritizing self-care and making informed lifestyle choices can cure and protect your heart. Discover actionable strategies to enhance your cardiovascular wellness. #HeartHealth #SelfCare #Wellness

A Note from James:I particularly want to reverse my aging. I'm not concerned about being able to run a mile or anything like that; I just want to reverse the aging of my brain. I feel there's a definite difference between my brain now and when I was younger. By the way, culturally, we acknowledge that the brain ages. Not only medically, but culturally, you have to adapt to being the wise older person rather than the sharp young person.We had a great conversation with Arthur Brooks about this. He wrote an excellent book, which I can't recommend enough, called "From Strength to Strength." That podcast with Arthur Brooks changed my life in how I view my brain aging. Additionally, several podcasts with David Sinclair about the aging process have also been life-changing.I have used the supplements he recommended and made the lifestyle changes he suggested back in 2019. David has conducted a lot of research in the five years since his book "Lifespan" was released, and I wanted to see what the current state of his research was. So, he came on the podcast.I'm very grateful; he doesn't do many podcasts. He shared some incredible discoveries and new information, giving me real insight. We discussed everything related to what he's doing in anti-aging and what he's discovered since the last time I had him on. At the special request of our listeners, I also asked him about testosterone.Towards the end of the podcast, I asked him about that, and his answer was very interesting. Here's David.Episode Description:Today, James discusses personal motivations for wanting to reverse aging, specifically targeting brain aging. The conversation moves into the broader cultural and scientific understandings of aging, touching on insights from Arthur Brooks and David Sinclair's research. Sinclair's work on anti-aging, including lifestyle changes and supplement use recommended by him, is highlighted, mentioning his book 'Lifespan' and the progress in his research over the past five years. Key discussions include the information theory of aging, the role of DNA and epigenetics in aging, and the concept of age reversal through maintaining or restoring the epigenome's integrity. The episode covers the potential of using Yamanaka factors for age reversal, the challenges in translating these findings from mice to humans, and regulatory considerations for human trials. Sinclair also touches on his ongoing work in developing chemical cocktails for age reversal, comparing lifestyle changes to these scientific advances.  Episode Summary:00:00 The Quest for Age Reversal: Personal Motivations and Influential Conversations01:11 Diving Deep into David Sinclair's Research on Anti-Aging02:24 Exploring the Information Theory of Aging and DNA's Role04:30 The Potential of Epigenetics in Reversing Aging07:14 The Challenges and Ethics of Age Reversal Technologies09:01 The Future of Anti-Aging: From Gene Therapy to Accessible Pills10:53 Debunking Myths and Addressing Controversies in Anti-Aging Supplements15:13 The Cutting-Edge of Aging Research: Yamanaka Factors and Epigenetic Reset25:05 The Philosophical and Practical Implications of Rejuvenation Research27:57 Unveiling New Breakthroughs in Cellular Biology28:19 Decoding the Mystery of Emanarcha Factors29:18 Exploring the Potential of Yamanaka Factors in Age Reversal29:43 The Future of Age Reversal: From Theory to Practice30:52 Innovative Approaches to Rejuvenation and Safety Measures31:52 Understanding the Complexity of Aging Across Different Organs34:57 The Fascinating World of Epigenetic Aging and Brain Plasticity37:20 Pushing the Boundaries: Chemical Cocktails for Rejuvenation39:46 Comparing Lifestyle Factors and Chemical Interventions in Aging40:56 Exploring the Possibilities of Reversing Menopause in Mice45:09 Navigating the Path to Human Trials and Regulatory Approval49:18 The Potential and Ethics of Off-Label Uses for Gene Therapy53:53 Personal Insights and Experiments in Anti-Aging ------------What do YOU think of the show? Head to JamesAltucherShow.com/listeners and fill out a short survey that will help us better tailor the podcast to our audience!Are you interested in getting direct answers from James about your question on a podcast? Go to JamesAltucherShow.com/AskAltucher and send in your questions to be answered on the air!------------Visit Notepd.com to read our idea lists & sign up to create your own!My new book, Skip the Line, is out! Make sure you get a copy wherever books are sold!Join the You Should Run for President 2.0 Facebook Group, where we discuss why you should run for President.I write about all my podcasts! Check out the full post and learn what I learned at jamesaltuchershow.com------------Thank you so much for listening! If you like this episode, please rate, review, and subscribe to “The James Altucher Show” wherever you get your podcasts: Apple PodcastsiHeart RadioSpotifyFollow me on social media:YouTubeTwitterFacebookLinkedIn

Dr. Diana I. Jalal and Colin Gimblet discuss the findings of their study, "Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial," on behalf of their colleagues.

People living with HIV have an increased risk of developing cardiovascular disease, including coronary artery disease. Until now, it has been unclear why. In this episode, Guest Editor Dr. Ashley Walker (University of Oregon) interviews author Dr. Efthymios Ziogos (Johns Hopkins Medicine) and expert Dr. Jennifer Williams (McMaster University) about the recent study by Ziogos et al. published in the Call for Papers Impact of Aging on CV System. Ziogos and co-authors used advanced MRI to assess coronary endothelial function noninvasively and without contrast in order to compare endothelial-dependent vasoreactive responses in coronary arteries to isometric handgrip exercise, both in people living with HIV and HIV negative individuals. The authors found that coronary endothelial function was impaired in people living with HIV, compared to HIV negative individuals. While it is known that there is a negative correlation between age and coronary endothelial function in HIV negative individuals, the authors found no correlation between age and endothelial function in HIV positive individuals, suggesting early vascular aging in individuals with HIV. This study is truly an example of an important research question that went unaddressed until recently because of the need for the advanced measurement techniques used by Ziogos and collaborators. While there is still much to learn about HIV, this research offers new insights into the potential causes of increased coronary artery disease in people living with HIV, and provides new avenues for preventive cardiology research in this population. Listen now to find out more.   Efthymios Ziogos, Yaa A. Kwapong, Robert G. Weiss, Michael Schär, Todd T. Brown, Shashwatee Bagchi, Alborz Soleimanifard, Tarek Harb, Damani A. Piggott, Gary Gerstenblith, Thorsten M. Leucker, Allison G. Hays   Coronary Artery Endothelial Function and Aging in People with HIV and HIV-Negative Individuals   Am J Physiol Heart Circ Physiol, published October 9, 2023. DOI: 10.1152/ajpheart.00143.2023

In today's episode with Dr. Tom Guilliams, you'll hear us take a deep dive on: 1. The secrets of the endothelial glycocalyx 2. Potential biomarkers for assessing glycocalyx activity 3. The role of glycocalyx in cardiovascular health 4. Lifestyle factors that support endothelial health 5. Insights for maintaining cardiovascular health Dr. Tom Guilliams serves as the Director at Point Institute and the Adjunct Associate Professor at University of Wisconsin School of Pharmacy, boasting two decades of experience in the critical assessment of lifestyle, nutritional, and dietary supplement strategies aimed at both preventing and managing chronic diseases. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

IronRadio is back with regular weekly epsiodes! This week a buffed-up Statler and Waldorf - uh, Lonnie and Phil - muse on the popularity of one-legged training, then turn a listener mail on energy drinks into a full discussion on how they have used pre-workout-type stimulants over the years. --------- Subscribe at Apple iTunes: https://podcasts.apple.com/us/podcast/nutritionradio-org/id1688282387  Podcast on Spotify: https://open.spotify.com/show/1ECHrnjxjn33DBNWgErPtp Subscribe to our YouTube backup: https://www.youtube.com/lonman07?sub_confirmation=1 Podcast on Amazon/ Audible: https://www.audible.com/pd/NutritionRadioorg-Podcast/B0BS8LFLLX?qid=1675812257&sr=1-1&ref=a_search_c3_lProduct_1_1&pf_rd_p=83218cca-c308-412f-bfcf-90198b687a2f&pf_rd_r=YKEZ8DX192TQF0CQV8KX&pageLoadId=u3x6bJ1 Podcast web site: https://sites.libsyn.com/455769/site Sister site: https://www.ironradio.org/ 

References Free Radical Biology and Medicine Volume 71, June. Pages 1-15 Cardiovasc.Res. 2012 May 1; 94(2): 379–390. Int. J. Mol. Sci. 2020, 21(7), 2578; https://doi.org/10.3390/ijms21072578 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population. #longcovid #arginine #fatigue Tosato M, Calvani R, Picca A, Ciciarello F, Galluzzo V, Coelho-Júnior HJ, Di Giorgio A, Di Mario C, Gervasoni J, Gremese E, Leone PM, Nesci A, Paglionico AM, Santoliquido A, Santoro L, Santucci L, Tolusso B, Urbani A, Marini F, Marzetti E, Landi F on behalf of the Gemelli against COVID-19 Post-Acute Care Team. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial. Nutrients. 2022; 14(23):4984. https://doi.org/10.3390/nu14234984 Long covid, fatigue, arginine, liposomal c, vitamin c, recovery, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms --- Support this podcast: https://anchor.fm/ralph-turchiano/support

Long Covid Fatigue L-Arginine Liposomal C l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population. #longcovid #arginine #fatigue Tosato M, Calvani R, Picca A, Ciciarello F, Galluzzo V, Coelho-Júnior HJ, Di Giorgio A, Di Mario C, Gervasoni J, Gremese E, Leone PM, Nesci A, Paglionico AM, Santoliquido A, Santoro L, Santucci L, Tolusso B, Urbani A, Marini F, Marzetti E, Landi F on behalf of the Gemelli against COVID-19 Post-Acute Care Team. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial. Nutrients. 2022; 14(23):4984. https://doi.org/10.3390/nu14234984 Long covid, fatigue, arginine, liposomal c, vitamin c, recovery, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms --- Support this podcast: https://anchor.fm/ralph-turchiano/support

The ALL ME® Podcast Energy Drinks: How Significant is the Risk- Dr. John Higgins At some point in your day, have you had that feeling like you need a pick me up to get through the day. Some people start every morning with a cup of coffee. Others feel the need to grab an energy drink to get a boost to get through their diet. BUT, could that energy drink be causing more damage to your body, especially your heart, than you realize. In 2020, the energy drink industry generated $57 million dollars in revenue and that is expected to grow by 7-9% in the next 4-5 years. We are now seeing middle school children consuming energy drinks in addition to young athletes using these prior to high intensity exercise which can pose a significant risk.   During our interview we talk about the potential risk of mixing caffeine, taurine, and other stimulants like guarana seed extract and panax ginseng. These ingredients also see an increase in utilization when combined with glucose (i.e. sugar). In this episode, we speak with Dr. John Higgins, Sports Cardiologist, to discuss his research outcomes on the impact energy drinks have on the cardiovascular system in healthy individuals. Dr. Higgins will discuss what ingredients are in these drinks, which ones may be posing a risk, what did his research determine on cardiovascular health and would he recommend consumers drink them? About Dr. Higgins John Higgins, MD, MBA, MPHIL, FACC, FACP, FAHA, FACSM, FASNC, FSGC is a Professor of Medicine at the McGovern Medical School at the University of Texas. He is also a Senior Cardiologist at Lyndon B. Johnson General Hospital and Director of Exercise Physiology at Memorial Hermann Institute for Sports Medicine and Human Performance. He is also a Sports Cardiologist with the Houston Rockets and Rice Athletics. He has appeared over 700 times on local TV and radio including CNN and ABC World News. He is the author of 3 books, 2 book chapters, 55 manuscripts, 308 web-based publications, and 16 abstracts. Energy Drinks Content and Safety: Energy Drinks: A Contemporary Issues Paper:   Some Popular Energy Shots and Their Ingredients: Are they safe and should they be used? A Literature Review: Stimulant Containing Energy Drinks: What you need to know? Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiovascular Complications of Energy Drinks: Endothelial function acutely worse after drinking energy beverage: Follow Us: Twitter: @theTHF Instagram: @theTHF Facebook: Taylor Hooton Foundation #ALLMEPEDFREE Contact Us:  Email:  Phone: 214-449-1990 ALL ME Assembly Programs:

In this episode we discuss the potential impact of dietary polyphenols on cardiovascular disease risk; including impacts on blood pressure, flow-mediated dilation, and other related outcomes. We talk about some potential mechanisms and then several specific randomized, controlled trials. You can find the show notes at sigmanutrition.com/episode407/ and you can support the podcast on patreon.com/sigmanutrition

Welcome to the DAILY DROP from The New Science of Physical Health.Today's episode is all about the language of LIFE INSIDE YOUR BODY. Endothelial function. We know the language of our favourite obsession (mine is Marvel Movies) - but not life inside our body. Let's change this now!The first mini-series is called: THE THOMAS EDISON OF HEALTH TECHNOLOGY  IN THE 2020'S.  It will be ready very soon for those who self-select and want to deep dive into Life Inside Your Body. CLICK THE LINK BELOWhttps://forms.gle/tdqUPskRCEosZiXG7 (THIS IS THE THOMAS EDISON MINI-SERIES LINK)To access our brand new book and a special offer for listeners to this show: click here:https://go.expertroadmaps.com/entry-pager568o5dv To get access to TURN BACK YOUR BODY CLOCK - click this link.https://forms.gle/HgAGFbMxMkxUCeQ58To get access to THE PERFECT HEALTH LESSON  web class - click this linkhttps://forms.gle/hG2KZUZcndBu15dJ8

Peter Dobromylskyj is a UK-based veterinary anaesthetist and nutrition blogger whose blog Hyperlipid is amongst the longest-running and most highly respected in the low-carb and ancestral health communities. Peter has been writing about the biochemistry of nutrition since 2006, and has authored over 800 posts aimed at reviewing, analysing, and interpreting nutrition literature. Given his outside-the-box thinking and unconventional approach to metabolism and health, Peter's work has amassed a large and devoted following. Today, NBT Scientific Director Megan Hall interviews Peter to talk about insulin resistance, including the factors that cause it and why the condition is actually physiologically adaptive. Peter compares dietary saturated fats to polyunsaturated fatty acids (PUFAs), and explains why the scientific literature can be misleading when determining which truly promotes health. He gives specific science-based recommendations for how much PUFA to include in your diet, and also offers advice on what to feed your pets. For additional resources on insulin resistance and the influence of dietary fat sources, be sure to see the outline Megan wrote to prepare for this podcast. Here's the outline of this interview with Peter Dobromylskyj: [00:01:52] Insulin resistance is physiologically adaptive. [00:02:23] Reactive Oxygen Species (ROS) as signaling molecules. [00:04:52] Dr. David Speijer, Researcher at the University of Amsterdam. [00:05:31] Dr. Nick Lane, Professor of Evolutionary Biochemistry. [00:11:29] Protons thread on the Hyperlipid blog. [00:22:58] When insulin sensitivity becomes insulin resistance. [00:30:37] How long it takes to become insulin resistant. [00:34:55] Acipimox reduces free fatty acid circulation and temporarily reverses insulin resistance; 1. Santomauro, A. T., et al. "Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects." Diabetes 48.9 (1999): 1836-1841; 2. Aday, Aaron W., et al. "Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial." Obesity 27.11 (2019): 1812-1819. [00:36:19] Effects of caffeine on insulin resistance. [00:37:34] Phil Maffetone. [00:38:25] In mice, stearic acid reduces visceral adipose tissue; Study: Shen, Ming-Che, et al. "Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice." PLoS one 9.9 (2014): e104083. [00:38:34] Overfeeding studies in humans: 1. Rosqvist, Fredrik, et al. "Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans." Diabetes 63.7 (2014): 2356-2368; 2. Iggman, David, et al. "Association of adipose tissue fatty acids with cardiovascular and all-cause mortality in elderly men." JAMA cardiology 1.7 (2016): 745-753. [00:44:10] Raphael Sirtoli's Podcast: Carnivore Cast. [00:45:02] Butter fat → higher postprandial levels of FFAs and triglycerides; Study: López, Sergio, et al. "Distinctive postprandial modulation of β cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids." The American journal of clinical nutrition 88.3 (2008): 638-644. [00:46:50] Tucker Goodrich. [00:47:38] How much polyunsaturated fat is needed to cause metabolic dysfunction? [00:48:27] Leptin-deficient mouse study: Reeves, Valerie Lynn. "A diet enriched in stearic acid protects against the progression of type 2 diabetes in leptin receptor deficient mice (DB/DB)." (2012). [00:49:57] Aim for 2-4% of calories from linoleic acid (over 8% is obesogenic). [00:51:26] Efforts to lose weight with unsaturated vs. saturated fat stores. [00:53:29] Animal based keto with 15% polyunsaturates; Study: Hall, Kevin D., et al. "Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake." Nature Medicine 27.2 (2021): 344-353. [00:58:46] Electron transport chain (see this figure) and mitochondria. [00:58:57] Summary so far. [01:01:33] What dogs/pets should be eating. [01:09:05] Labradors may have problems with leptin signaling; Book: Raw Meaty Bones Promote Health, by Tom Lonsdale.

In this episode of Science & Chill, I discuss our lab's recently published systematic review on the effects of sleep deprivation on blood vessel health and function in adults.   Links - Read the Paper: Effects of Sleep Deprivation on Endothelial Function in Adult Humans: A Systematic Review - Sign up for my Physiology Friday newsletter  - Become a podcast supporter on Patreon - Check out my blog - Get your FREE LMNT sample pack - Donate to the podcast

In this episode Dr. Austin Robinson and I are joined by Dr. Rich Severin to discuss the paper we covered on the last episode of the podcast which examined the effects of obesity and bariatric surgery on cardiovascular health and carotid intima-media thickness at a 3-year follow-up. We also discussed some of the exciting work Rich currently is doing as a part of his dissertation on the effects of obesity and endothelial function as well as his recent review paper entitled, “Endothelial Function in Obesity and Effects of Bariatric and Metabolic Surgery” (DOI below). Rich is a Doctor of Physical Therapy and a PhD candidate at the University of Illinois at Chicago under Dr. Shane Philips. Review Article DOI: 10.1080/14779072.2020.1767594  TIME STAMPS Episode Introduction                                                                                            00:00:00 – 00:01:26 Catching Up with Rich and Rich's Background                                                 00:01:26 – 00:16:25 State of the Literature and The “Fat Years” Concept                                       00:16:25 – 00:30:25 Effect of Metabolic Surgery on Intima Media Thickness (IMT)                        00:30:25 – 00:36:25 Potential Role of Improved Sleep Following Metabolic Surgery on IMT          00:36:25 – 00:43:30 Potential for Exercise to Modulate Endothelial Function in Obesity                00:43:30 – 00:48:00 Overcoming Physical and Psychological Barriers Associated with Obesity   00:48:00 – 00:54:00 Rich's Other Interests, Projects and Next Steps                                                00:54:00 – 01:03:00 Rich's Contacts on Social Media                                                                          01:03:00 – End

Sleep disorders, such as insomnia, sleep apnea and restless leg syndrome, have acute and chronic negative cardiovascular impacts. Why is so little known about the cellular and molecular mechanisms regulating cardiovascular events in sleep disorders? In this podcast Editor-in-Chief Dr. Irving H. Zucker interviews lead author Dr. Maureen MacDonald (McMaster University) and expert Karyn Esser (University of Florida) about an insightful new Review article by Cherubini et al. MacDonald and co-authors became interested in the affect sleep has on endothelial function while conducting their own exercise physiology studies. Reviewing the literature, Cherubini et al. found that most studies do not control for sleep, yet sleep deprivation – whether acute or chronic, partial or total – can have negative effects on endothelial function in humans. The literature also shows similar results in animal and cell culture models. Because clock mechanisms exist in every human cell type, the understanding of links between so-called “clock genes” and disease progression is an emerging field. How does this relate to the development of atherosclerotic plaques, and the potential for exercise as a therapeutic strategy to combat the negative impact of disordered sleep? Listen now.   Joshua M. Cherubini, Jem L. Cheng, Jennifer S Williams, Maureen J. MacDonald Sleep deprivation and endothelial function: reconciling seminal evidence with recent perspectives  Am J Physiol Heart Circ Physiol, published October 16, 2020. DOI: doi.org/10.1152/ajpheart.00607.2020

Abnormal blood lipids—such as alterations in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C)—are major risk factors for cardiovascular disease (CVD). Known collectively as dyslipidemia, these abnormal lipid fractions have a prevalence of 38.6% among individuals aged 40 and above—with alterations of one out of five US children and adolescents aged 8 to17 years—according to research—Ubiquinol (CO Enzyme Q10) Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial, which appeared in the August 2020 issue of the journal Nutrients.The endothelium is the largest organ in the body—composed of a layer of cells that lies between the wall of blood vessels and the bloodstream. It is a living shield that keeps the arteries clear of build-up and blockage, so that essential oxygen and nutrients can get to the vital organs of the body.In addition, endothelial cells are involved in many aspects of vascular structure—acting as a barrier between the vessel lumen and surrounding tissue, while controlling the passage of materials and the transit of white blood cells into and out of the bloodstream.The authors of the Nutrients study from South Africa and Italy state that, "The impairment of endothelial function (EF) predates the morphological changes of atherosclerosis and can mechanistically contribute to atherosclerosis-related diseases."Endothelial function can be assessed by flow mediated dilation (FMD), which, "assumes that endothelial dysfunction (ED) is a systemic process involving the coronary arteries, as well as, the peripheral circulation."Using ultrasound technology, FMD estimates, "the dilation of a large peripheral conduit artery, typically the brachial artery, in response to the increased blood flow resulting from the removal of a transient ischemic stimulus." FMD has proved effective in evaluating the impact of several interventions on ED.The researchers point out that coenzyme Q10 (CoQ10)—especially in its reduced form known as ubiquinol—"has improved endothelium-dependent vasodilation, as measured by FMD, in patients with type 2 diabetes, or coronary artery disease (CAD). However, the evidence of its effect on ED in subjects without clinical manifestations of atherosclerosis-related disease is limited."Mayoclinic.org states that CoQ10, "is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance. Levels of CoQ10 in your body decrease as you age. CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease."CoQ10 is found in meat, fish and whole grains. The amount of CoQ10 found in these dietary sources, according to Mayo, isn't enough to significantly increase CoQ10 levels in your body.The Nutrient study authors sought to determine whether an 8-week ubiquinol supplementation period enhanced endothelium-dependent vasodilation in adults with moderate, untreated dyslipidemia and without evidence of CVD. The researchers recruited fifty-one subjects with low-density lipoprotein (LDL) cholesterol levels of 130-200 mg/dL, who were not taking statins or other lipid lowering treatments—with moderate (2.5%–6.0%) endothelial dysfunction, as measured by flow-mediated dilation (FMD) of the brachial artery, and no clinical signs of cardiovascular disease. During the study period, the participants were randomized to receive either ubiquinol (200 or 100 mg/day) or a placebo. The primary objective was to determine the effect of the ubiquinol supplementation on FMD by the end of the study period.Read the rest at Mackieshilstone.com

Welcome! and Thank you for listening.  Don't eat that burger, it will destroy your endothelial cells.  That statement would make someone plant based immediately; correct? Vaping damages your lungs making you more susceptible to infections. How about high cholesterol is a risk factor for multiple sclerosis as is diabetes and being overweight.  That animal fat you are consuming on your cheese pizza is causing the production of TMAO by your gut microbes that will cause inflammation in your blood vessels.   What is a person left to eat?  Cardboard? I am living proof as are many others that you can enjoy every meal and still be healthy.  Everyone is in to blaming these days.  Blaming others for not being considerate if they don't wear masks and infect those that are immune compromised.  Blaming businesses and governments for what they are or are not doing to prevent the current pandemic; SARS-COV-2.  Do we blame someone for decreasing the lifespan of  someone with cardiovascular disease if they take them to a restaurant that has noting but high fat, high cholesterol food choices.  Do we blame someone for the cardiovascular disease death or MI in a person if they bring in high salt, high fat snacks into the house of someone trying to reverse their vascular disease and eating in front of them knowing that most people cannot resist that temptation?  Perhaps we should take back the risk of our life to ourselves.  As we age the risk of living increases.  Some much quicker than others. But blaming others is not the answer.   Today I discuss why children do better with COVID-19 than adults.  I also discuss the need for us to clean up our own house that is full of metabolic waste products that damage our immune system.  Eating meat and a high fat diet increases the production of TMAO that is an inflammatory compound involved in the progression of vascular disease.  Hypertension and cardiovascular disease is the result of damaged endothelial cells that line the blood vessel.  These are also the risk for clotting during an infection with COVID-19.  They are reversible through plant based nutrition but it is difficult especially when you are trying to go it alone.   Protecting your family starts at the dinning table.  It starts with the food you prepare and purchase.  It is the best money you will ever spend on your health.   I hope you enjoy the podcast. You can pick up a copy of our Plant Based Family Cookbook at https://www.amazon.com/gp/product/1733967702/ref=ppx_yo_dt_b_asin_title_o01_s00?ie=UTF8&psc=1  Check out the website if you would like to join our online program to reverse lifestyle diseases. You will have complete access to our full membership content plus monthly personal audio chats with me and my registered dietitian, Addie Majnaric, RDN.  doctordulaney.com Thank you for listening!

Dyslipidemia, the characteristic change of one or more blood lipid (fat) components – including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (Trig), and high-density lipoprotein cholesterol (HDL-C) – is an established risk factor for cardiovascular disease (CVD).According to Italian research – Ubiquinol (co-enzyme Q-10) Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trail —dyslipidemia, “has a prevalence of 38.6% among individuals aged 40 years and above, and the alteration of TC, HDL-C, or non-HDL-C has been reported in one out of five US children and adolescents aged 8–17 years.”Stanfordhealthcare.org says, “endothelial dysfunction is a type of non-obstructive coronary artery disease (CAD) in which there are no heart artery blockages, but the large blood vessels on the heart’s surface constrict (narrow) instead of dilating (opening).”This condition, comments Stanford, “tends to affect more women than men and causes chronic chest pain. Because most clinics do not diagnose or treat endothelial dysfunction, people with this condition may feel frustrated and hopeless.”The vascular endothelium is critical in maintaining vascular balance – capable of sensing alterations in vessel walls and releasing a variety of autocrine (a substance secreted by a cell on its surface structure) and paracrine (stimulate cell regeneration) substances to protect the cell wall integrity.COQ-10 and its bioactive form ubiquinol, exert antioxidant protection by preventing the oxidation of LDL-C, while also improving endothelium-dependent vasodilation (opening). “CoQ10 has improved endothelium-dependent vasodilation, as measured by FMD (flow mediated dilation), in patients with type 2 diabetes, or coronary artery disease,” notes the study authors.The Italian researchers sought to determine, if an 8-week ubiquinol supplementation period enhances endothelium-dependent vasodilation in adults with moderate, untreated dyslipidemia and without evidence of CVD. The primary study outcome was to measure the effect of COQ-10 (ubiquinol) on FMD of an artery, when blood flow increases or not in that artery. A secondary outcome included the assessment FMD and changes in COQ-10 status at weeks 4 and 8 – along with changes in vasodilators nitrite and nitrate levels, and LDL-C oxidation at week 8. The Italian’s study participants included fifty-one subjects with low-density lipoprotein (LDL) cholesterol levels of 130–200 mg/dL, not taking statins or other lipid lowering treatments, moderate (2.5%–6.0%) endothelial dysfunction, as measured by FMD of the brachial artery, and no clinical signs of cardiovascular disease, who were randomized to receive either ubiquinol (200 or 100 mg/day) or placebo for 8 weeks. At the study completion, it was determined that, “ubiquinol significantly ameliorated (make more acceptable) dyslipidemia-related endothelial dysfunction. This effect was strongly related to increased nitric oxide bioavailability and was partly mediated by enhanced LDL antioxidant protection.”The take-away message is clear that COQ-10 is another option, with medical supervision, in the non-pharmaceutical tool kit to help address, along with diet and exercise, the negative health effects of dyslipidemia.Sign up for Mackie Mail, on mackieshilstone.com - my free, weekly wellness update with Fitness in Small Spaces 90-second videos on Monday, my Maximum Wellness podcast and script on Wednesday, and, on Friday, you’ll receive my WWL/WUPL TV 3-minute Workout Wednesday segment. You can also contact spencer@mackienutrition.com should you desire nutrition product to be shipped or locally delivered to your door. My 4 locally operated GNC franchise stores are open, regularly sanitized – with appropri

In this episode we talk with Professor Lacy Alexander of Penn State University about her lab's most recent publicationSelf-Reported Everyday Psychosocial Stressors Are Associated With Greater Impairments in Endothelial Function in Young Adults With Major Depressive DisorderFollow along with the article here!https://www.ncbi.nlm.nih.gov/pubmed/30741602The link to their second paper from the same study is herehttps://www.ncbi.nlm.nih.gov/pubmed/31751182

As general rule, documentaries need to be fact checked. Unfortunately most have a biased agenda and the producers  will bend the facts or just lie in order to support their beliefs. This is the opposite of science. A good scientist states his/her beliefs and then conducts a rigorous investigation to prove it wrong. The good scientist then publishes the findings whether or not it supports his/her beliefs. This did not happen in "The Game Changers".  Here are some quick notes on the lies they use in "The Game Changers": 1. LIE: Gladiators were vegetarians and prized fighters with the best medical care. TRUTH: Gladiators treated like animals or slaves led to slaughter for entertaiment. They were fed a plant based diet similar to what they would feed their animals in order to fatten them up. The fat was intended to protect them from minor cuts and strikes. It was an insult back then to call someone "barley eater". Meat was cherished and considered a privilege. One of the physicians at the time, Aelius Galenus critized the diet and the training of the gladiators. He said it was not proficient.  2. LIE: Carbs are the main energy source and without them you will experience chronic fatigue. TRUTH: Carbs are only the main energy source during intense exercise. Even then the energy is split 50% from carbs and 50% from fat. It is extremely silly to claim carbs are the body's preferred energy source, especially with the Keto Diet being all the rage. More people, now more than ever, know once your body is fat adapted it runs efficiently with fat providing up to 95% of a person's energy. Your body can also convert fat into carbs. This means you do not need to eat carbs. 3. LIE: Meats cause vasoconstriction and endothelial inflammation. TRUTH: There are no peer reviewed studies that state this. In fact, the study they site in the film says in the title "Saturated Fatty Acids do not impair Endothelial Function". The study goes on to say no significant differences were shown between saturated fatty acids and monounsaturated fatty acids. 4. LIE: Humans do not have any specialized biological mechanisms to digest meat. TRUTH: Humans (omnivores) have more in common with carnivores than herbivores. Herbivores have an extremely long intestinal track, and some like cows, have multiple stomachs. In comparison humans have a much shorter intestinal track and one stomach. Herbivores have only flat teeth. Humans have sharp and flat teeth. Herbivores have a high ph level for digesting tough plants. Humans and carnivores both have a low ph level.  5. LIE: The antioxidants we need are found almost entirely in plants. TRUTH: Most antioxidants in plants have very low bio-availability. The most important antioxidant, glutathione, is made by the human body. It is really the only one we need, and is comprised of the amino acids glyciene, glutamine, and cysteine, which come from protein. I will stop there. The film is rife with inaccuracies, horrible anecdotal stories from athletes and celebrities, and lots of blatant lies. I hope you enjoy the podocast! --- Support this podcast: https://anchor.fm/dane-whitted1/support

A very controversial documentary was released on Netflix a few weeks ago and as it is usually expected from most documentaries: It had an agenda.  Let’s just start by stating important facts. As sports registered dietitian, I am NOT against plant-based diets, vegetarianism or veganism, however, I have a strong case against content that is misleading and filled with misinformation. Sadly this is the case for the Games Changers documentary and the agenda they push to advocate for veganism by presented facts that are misconstrued and manipulated to present their version of the truth. I am NOT saying that being a vegan is a bad approach to health, on the contrary, it is something I support, but not in an environment that creates superiority over other dietary regimes, even more so in a population that is known to be uneducated on basic nutrition principles  I waited a couple of weeks to watch this documentary as I always like to dive into the rebuttals and responses from all communities. I used a couple of great reviews that presented factual information and contextual research to support or go against some of the claims in this documentary   Meredith Root - THE GAME CHANGERS – A SCIENTIFIC REVIEW WITH FULL CITATIONS Dr. Ryan Lowery - Fact or Fiction: Debunking The Game Changers Movie Here are some of the arguments made in this documentary  Gladiators in ancient times were vegan or plant-based eaters  Plant-based Athletes have more endurance and perform better on a plant-based diet  Plant-based protein sources are of high quality and more complete sources than animal-based sources Plant-based Diets support endothelial function  Animal-based diet is related to heart disease and heart problems Consumption of meat is directly related to cancer Erectile Strenght and duration is higher after consuming a plant-based food Farming and Green House Emissions and the environmental impact of meat consumption is worse than the effect of transportation (cars, planes, ships, etc)    During this episode, I dissected some (not all of those claims) in detail and provided references below. I pulled these references from the article written by Meredith Root here   Gladiator Diets   Nucilli, R. (2018). Gladiators Diets Were Carb-Heavy, Fattening, and Mostly Vegetarian. Atlas Obscura. https://archive.archaeology.org/0811/abstracts/gladiator.html   These are the studies cited with regards to vegetarian diets for athletes: https://pdfs.semanticscholar.org/6358/c99b8b7047fd99f0867e148840829a125dd0.pdf https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-86 https://www.ncbi.nlm.nih.gov/pubmed/26764320 Endothelial Function https://www.ncbi.nlm.nih.gov/pubmed/11254924 https://www.researchgate.net/publication/12166386_Impaired_flow-mediated_vasoactivity_during_post-prandial_phase_in_young_healthy_men https://www.ncbi.nlm.nih.gov/pubmed/23196671 https://www.ncbi.nlm.nih.gov/pubmed/10477529 https://www.ncbi.nlm.nih.gov/pubmed/20047267 https://www.ncbi.nlm.nih.gov/pubmed/24004888 https://www.ncbi.nlm.nih.gov/pubmed/19064532 https://www.ncbi.nlm.nih.gov/pubmed/15165919 https://www.ncbi.nlm.nih.gov/pubmed/24742818 https://www.ncbi.nlm.nih.gov/pubmed/22019438 https://www.ncbi.nlm.nih.gov/pubmed/11834139 https://www.ahajournals.org/doi/full/10.1161/01.cir.104.2.151 https://www.ncbi.nlm.nih.gov/pubmed/17916273 https://www.ncbi.nlm.nih.gov/pubmed/17609490 https://www.ncbi.nlm.nih.gov/pubmed/23848379 https://www.ncbi.nlm.nih.gov/pubmed/16027246 https://www.ncbi.nlm.nih.gov/pubmed/16365364 https://www.ncbi.nlm.nih.gov/pubmed/15547040 https://www.ncbi.nlm.nih.gov/pubmed/26024297 https://www.ncbi.nlm.nih.gov/pubmed/24706588 https://www.ncbi.nlm.nih.gov/pubmed/22091240 https://www.ncbi.nlm.nih.gov/pubmed/15190043 https://www.ncbi.nlm.nih.gov/pubmed/16198843 Beet Root https://www.ncbi.nlm.nih.gov/pubmed/29311764 Antioxidants https://www.ncbi.nlm.nih.gov/pubmed/30634559 https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-9-3 https://www.betterhealth.vic.gov.au/health/healthyliving/antioxidants https://www.ncbi.nlm.nih.gov/pubmed/25637150 Plant-Based Guide for Physicians https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991921/ Heme Iron https://www.ncbi.nlm.nih.gov/pubmed/23708150 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583546/) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954454/ Heart Disease https://www.ncbi.nlm.nih.gov/pubmed/24871675 https://www.ncbi.nlm.nih.gov/pubmed/1973470 https://www.ncbi.nlm.nih.gov/pubmed/24606898 Cancer Risk https://www.ncbi.nlm.nih.gov/pubmed/11519764 https://www.ncbi.nlm.nih.gov/pubmed/9786231   To connect with me:  To download my FREE INTERMITTENT FASTING GUIDE tap here https://vive-nutrition.com/intermittent-fasting-course/ On Instagram www.instagram.com/andresayesta and if you want to stay-up-to-date on these episodes www.instagram.com/vivenutrition On Youtube www.youtube.com/c/vivenutrition On Facebook www.facebook.com/vivenutrition For nutrition coaching apply at www.vive-nutrition.com/online-coaching 

Kirk’s overview video of Dr. Budoff interview (4:00 min) Why Study a Nitrate Rich Beetroot Product? Dr. Budoff is interested in studying nutraceutical products claiming they can increase nitric oxide to validate their efficacy and understand how they work. Nitric Continue reading The Benefit of a Nitrate Rich Beetroot Supplement Lowering Blood Pressure and Improving Endothelial Function in Pre-Hypertensive Subjects – An Interview with UCLA Cardiologist Matthew J. Budoff, MD→ The post The Benefit of a Nitrate Rich Beetroot Supplement Lowering Blood Pressure and Improving Endothelial Function in Pre-Hypertensive Subjects – An Interview with UCLA Cardiologist Matthew J. Budoff, MD appeared first on .

Commentary by Dr. Valentin Fuster

Speaker 1: 00:00 This is Dr Chad Edwards and you’re listening to podcast number 92 of against the grain. Speaker 2: 00:06 This is Diana Edwards and I’m here with Dr Chad Edwards and we’re talking about a very important topic today. We’re talking about cardiovascular disease, Speaker 1: 00:15 cardiovascular disease, that seems like […] The post Episode 92 – Endothelial Function appeared first on Revolution Health & Wellness.

On this episode, we welcome Dr. Joel Kahn to the show. He is a decorated cardiologist and a Clinical Professor of Medicine at Wayne State University School of Medicine in Detroit. Dr. Joel is a proponent of using lifestyle choices to prevent and even reverse heart disease. We discuss diet and dietary fat, heart health, The Daniel Plan, The North Karelia Project, Ancel Keys, commonalities between Paleo and Vegan diets, and much more. Links for this episode:Plant Paleo Part 2: Grains, Legumes, Fiber, and Antinutrients – Humans Are Not BrokenHidden Kingdoms: Launch Trailer - BBC One - YouTubeHidden Kingdoms on NetflixNatural Treatments and Preventative Methods to Heart HealthDr. Joel Kahn on mindbodygreenJoel Kahn MD (@drjkahn) | TwitterTwo-Week International Diet Swap Shows Potential Effects of Diet on Colon Cancer RiskOrnish Lifestyle MedicineThe Daniel PlanAthlete/Author Rich RollDietary fat and heart disease study is seriously misleading | The Nutrition Source | Harvard T.H. Chan School of Public HealthNorth Karelia Project « Heart Attack PreventionEt Tu, Olive Oil? Fats and Endothelial FunctionNew Report Questions Health Benefits of Olive Oil | Linda Larrowe BergersenChimamanda Ngozi Adichie: The danger of a single story | TED Talk | TED.com

Some studies have suggested endothelial dysfunction in adult patients after repair of aortic coarctation (CoA), and it has been proposed to play a key role in the pathogenesis of arterial hypertension in the absence of re-coarctation. A study recently published in Heart aimed to assess the presence of endothelial dysfunction, the number of endothelial progenitor cells, and the levels of proinflammatory cytokines associated with endothelial injury in contemporary patients after CoA repair. Alistair Lindsay discusses what the work revealed with lead author Robert Radke, Division of Adult Congenital and Valvular Heart Disease, Department of Cardiology and Angiology, University Hospital Muenster. Read the full paper (for free): http://goo.gl/z32cOl

Learn About the Positive Benefits of Taking Coenzyme Q10 and Aged Garlic Extract on Cardiovascular Risk Factors, Vascular Elasticity and Endothelial Function, and the ABCs of Being "Heart Smart"! Kirk Hamilton interviews Matthew Budoff, MD, Professor of Medicine, David Geffen School of Medicine and Director of Cardiac CT at the Division of Cardiology at the Harbor-UCLA Medical Center in Torrance, California. Dr Budoff received his medical degree from the George Washington University School of Medicine in Washington, DC and completed an internship and residency in internal medicine, and a fellowship in cardiology, at Harbor- UCLA Medical Center. Dr Budoff has authored or co-authored more than 400 research papers, six books, and 36 book chapters. Most recently, he was named to the U.S. News & World Report list of Top Doctors for 2011. He is the co-author of the paper "Beneficial Effects of Aged Garlic Extract and Coenzyme Q10 on Vascular Elasticity and Endothelial Function: The FAITH Randomized Clinical Trial" in the journal Nutrition, August 2012. Download or Open:

Guest: Amir Lerman, MD Host: Larry Kaskel, MD They say a man is as old as his arteries. We can now tell our patients just how old they are with the FDA-approved Endopat2000, a noninvasive device that safely and quickly measures endothelial function and can help monitor response to treatment or interventions. Join host Dr. Larry Kaskel talking with Dr. Amir Lerman to learn more about measuring endothelial function.