Podcasts about Heart transplantation

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Peter Cho and senior author Abbas Ardehali, MD, to discuss the paper, “Severe primary graft dysfunction in heart transplant recipients using donor hearts after circulatory death: a United States Experience.” Peter is a third year medical student at Drexel University, and Dr. Ardehali is professor of surgery and medicine and the Director of the Heart, Lung, and Heart-Lung Transplant programs at UCLA. The episode explores: The study's findings regarding an increased incidence of severe PGD at 24 hours post-transplant in DCD over DBD recipients What risks weren't changed in DCD recipients—suggesting that DCD PGD is likely to be transient, and may have a different phenotype How NRP may impact the outcomes Mitigating the risk of PGD For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Tune in again later this month for the Digital Media Editors' findings and observations from the ISHLT2025 Annual Meeting in Boston. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

We have a wonderful program in store for you as The Word on Medicine brings you into the world of Heart Transplantation. It is hard to believe that this program is the 193rd unique show produced by The Word on Medicine since we began in October of 2017.   This Saturday, we welcome Drs. Buck Durham, Takushi Kohmoto, Jorge Mascaro, along with Annie Klamrowski, a nurse in the ICU, and of course, the perspective of one of our patients who is doing very well after a successful heart transplant. It is truly amazing to discover the many ways that broken hearts can be repaired and supported, and when all else fails, a new one can sometimes be the answer!

This week we review a recent PHTS study on long-term outcomes following heart transplantation. Why do patients develop coronary vasculopathy and how commonly is it seen at long term follow-up? What factors are associated with better or worse long term outcomes? How do 'adverse childhood experiences' result in worse outcomes for patients? Why do young transplant patients have better long-term outcomes and can this be leveraged to improve older patient outcomes? We speak with the first author of this week's work, Assistant Professor of Pediatrics at Ohio State and also from Nationwide Children's Hospital, Dr. Emily Hayes. DOI: 10.1111/petr.70042

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning examines surgical staplers. He explores the history of surgical staplers, the evolution of surgical staplers, and discusses the company that created the first automated minimally invasive surgical stapler—United States Surgical Corporation (USSC). He also discusses details about the AutoSuture Premium Poly stapler and why it is still being created. Joel also shares details about when he visited a production line that is responsible for creating surgical staplers. He discusses his experience and his highlights from this event, which includes meeting Dr. Rene Petersen and Dr. Laurens Ceulemans.  Joel also reviews recent JANS articles on heart transplantation and donation after circulatory death in children, priorities for medical device regulatory approval, transplantation of a genetically modified porcine heart into a live human, and mechanisms of repair failure after mitral valve repair using chordal replacement.   In addition, Joel explores treating intractable hiccups by clipping the phrenic nerve using VATS, robotic totally endoscopic CryoMaze ablation under ventricular fibrillatory arrest, and a new podcast episode from Dr. Alice Copperwheat, “The Atrium: Internal Mammary Artery Harvesting,” with expert guest Dr. David Taggart. Before closing, he highlights upcoming events in CT surgery.   JANS Items Mentioned  1.) Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework  2.) Priorities for Medical Device Regulatory Approval: A Report From the European Society of Cardiology Cardiovascular Round Table  3.) Transplantation of a Genetically Modified Porcine Heart Into a Live Human  4.) Mechanisms of Repair Failure After Mitral Valve Repair Using Chordal Replacement  CTSNET Content Mentioned  1.) Treating Intractable Hiccups by Clipping the Phrenic Nerve Using VATS  2.) The Atrium: Internal Mammary Artery Harvesting  3.) Robotic Totally Endoscopic Cryo-Maze Ablation Under Ventricular Fibrillatory Arrest  Other Items Mentioned  1.) Career Center   2.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

Returning for a second study this month, the JHLT Digital Media Editors invite lead author Oliver J.F. Weiner, to discuss the paper, “Sympathetic reinnervation in cardiac transplant recipients: Prevalence, time course, and association with long-term survival.” Dr. Weiner is currently an out of training registrar at Monash Health in Melbourne, Australia, but will soon return to his home of the UK to begin internal medicine training with the intention becoming a cardiologist. He is especially interested in advanced heart failure and electrophysiology. The episode explores: The uncertainty around clinical influences on reinnervation The importance of this single-center study in expanding the literature Potential future treatment options   For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Those on lung transplant teams should check the previous episode for a study on recent trends and post-transplant outcomes from EVLP. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

JHLT: The Podcast returns with a year-end recap of 2024. Each Digital Media Editor shares one of their favorite studies from JHLT in 2024 for a quick recap of last year's excellent science in advanced heart and lung disease. Studies featured: ·         Cardiac magnetic resonance assessment of acute rejection and cardiac allograft vasculopathy in pediatric heart transplant Kikano, Sandra et al. JHLT May 2024 5(43):745-754 ·         A modular simulation framework for organ allocation Rose, Johnie et al. JHLT Aug 2024 8(43):1326-1335. ·         HeartMate 3 Snoopy: Noninvasive cardiovascular diagnosis of patients with fully magnetically levitated blood pumps during echocardiographic speed ramp tests and Valsalva maneuvers Schlöglhofer, Thomas et al. JHLT Feb 2024 2(43):251-260. ·         Factors associated with acute limb ischemia in cardiogenic shock and downstream clinical outcomes: Insights from the Cardiogenic Shock Working Group Kochar, Ajar et al. JHLT Nov 2024 11(43):1846-1856.   For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Happy new year from JHLT: The Podcast! On this episode, the Digital Media Editors are joined by ISHLT Director of Marketing + Communications Jess Burke, CAE, to share a little bit about themselves and their backgrounds. Hear about how each of the JHLT Digital Media Editors got involved in transplantation and a little about each of their research and personal interests. For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors discuss a new guidelines document from the ISHLT entitled “The 2024 ISHLT Guidelines for the Evaluation and Care of Cardiac Transplant Candidates.” The lead co-authors of the document—Yael Peled, MD, and Anique Ducharme, MD, MSc—are on the podcast to discuss the document. You'll hear about: Challenges in drafting such an overarching document Highlights for clinicians Major changes in the document since the last version How changes in durable and temporary MCS affect use of the document For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Join us again later this month for a study on age matching in lung transplantation. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

In this special episode of JHLT: The Podcast, the Digital Media Editors connect with Joseph Rogers, MD, the new Editor-in-Chief of JHLT. In the conversation, Dr. Rogers shares more about his vision for the Journal, how he plans to tackle the challenges and opportunities facing the publication, and a little about his life both inside and outside of medicine. In addition to being the new Editor-in-Chief, Dr. Rogers is the President and CEO of the Texas Heart Institute in Houston, a past president of the ISHLT, and a prolific contributor to the field of heart and lung transplantation. For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

This week Bobbi Conner talks with Dr. Minoo Kavarana about pediatric heart transplantation. Dr. Kavarana is Chief of Pediatric Cardiothoracic Surgery & Surgical Director of Pediatric Heart Transplantation at MUSC Shawn Jenkins Children's Hospital.

Guests Dr. Douglas Overbey, Dr. Katie Cashen, and Dr. Erin Shea from Duke University discuss partial heart transplantation of pediatric semilunar valves. Co-hosts Deanna Todd Tzanetos, MD, MSCI and Misty, Ellis, DNP,APRN, CPNP-AC/PC (Norton Children's Hospital/U of Louisville) Editor/Producer: Deanna Todd Tzanetos, MD, MSCI (Norton Children's Hospital/U of Louisville)

Discover the remarkable progress made in heart failure therapies with Jonathan and Haider Warraich, Director of the Heart Failure Program at VA Boston Healthcare System, Massachusetts, USA. They also discuss the intricacies of heart transplantation and end-of-life care. Use the following timestamps to navigate the episode:  (00:00)-Introduction (03:28)-Warraich's journey into cardiology (06:15)-Recent advances in heart failure therapies (11:15)-What is the median survival from diagnosis of heart failure? (14:45)-The current state of heart transplantation (20:20)-Warraich's experience in regulatory medicine (24:33)-Warraich's book: ‘Modern Death, How Medicine Changed the End of Life' (33:45)-Warraich's s book: ‘State of the Heart' (40:12)-Warraich's most recent book: ‘The Song of Our Scars: The Untold Story of Pain' (46:13)-Warraich's three wishes for healthcare

This week we review a recent paper from last 2023 about outcomes of cardiac transplantation in the adult congenital heart patient (ACHD). Little has been written on this topic until this very robust and large scale report. How do single ventricle ACHD patients fair at transplant and how do they compare to non-ACHD heart transplant recipients? Why might 1 and 3 year outcomes not be a 'fair' method of assessing outcomes in this very high risk patient group? How do HLHS patient outcomes compare with other single ventricles? Are there better ways to measure risk in this patient group and how might the data in this work inform risk stratification and management of failing Fontan patients in whom transplantation is being considered? These are amongst the questions posed this week to the week's expert, Dr Daphne Hsu who is Professor of Pediatrics at the Albert Einstein College of Medicine at The Children's Hospital at Montefiore. https://doi.org/10.1016/j.jacc.2023.06.037For those interested in learning more about Dr. Hsu, take a listen to episode #166 from June, 2021:https://www.spreaker.com/episode/pediheart-podcast-166-a-conversation-with-professor-daphne-hsu--45144274

On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the July issue of The Journal of Heart and Lung Transplantation. Digital Media Editor Marty Tam, MD, a transplant cardiologist from the University of Michigan in Ann Arbor, hosts this episode.   First, Dr. Tam and Digital Media Editor Erika Lease, MD, FCCP, interview their first guest, Daniel Calabrese, MD, first author on the study “Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression.” The study's authors sought to tackle challenges behind early detection of chronic lung allograft dysfunction (CLAD) by identifying biomarkers associated with acute lung allograft dysfunction (ALAD) progression to CLAD.   To do this, they collected bronchoalveolar lavage (BAL) cells at the time of ALAD diagnosis and performed single cell RNA sequencing to identify significant differences in 26 unique cell populations across groups, with discordant CD8 T cells and macrophages providing the best discrimination between ALAD with decline from ALAD with recovery and controls.   Dr. Calabrese discusses how his team identified the diagnostic criteria, why the biomarkers might lead ALAD to progress to CLAD, and how the findings might lead to early targeted therapies.   Next, Dr. Tam joins and Digital Media Editor Khue Ton, MD and David Schibilsky, MD, to interview their next guest, David D'Alessandro, MD, the Surgical Director of Cardiac Transplantation and MCS at Massachusetts General Hospital in Boston. Dr. D'Alessandro was the first author on the study “Impact of controlled hypothermic preservation on outcomes following heart transplantation,” which sought to assess the impact of the Paragonix SherpaPak Cardiac Transport System, a device allowing controlled hypothermic  preservation, on rates of primary graft dysfunction (PGD) and post-transplant mortality.   The key finding was that controlled hypothermic preservation was associated with a lower incidence of severe PGD – 6.6% compared to ice storage at 10.4%. In the conversation, Dr. D'Alessandro answers questions about the need for innovation over traditional ice cold storage, the greatest advantages of controlled hypothermic approaches, and the next steps in this research.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

This week on The Beat, Editor in Chief Joel Dunning discusses upcoming interviews to be published on CTSNet. In addition, Joel discusses heart transplantation in adults with congenital heart disease, a commentary on revascularization, and gender representation among speaking and leader roles at CT surgery meetings. He also talks about a video demonstrating TAVR explantation, pulmonary stenosis correction after TAPVR correction, and a LAD to RCA anastomosis from Dr. Tristan Yan. Before saying goodbye, Joel discusses upcoming events in CT surgery. JANS Items Mentioned Trends and Outcomes of Heart Transplantation in Adults With Congenital Heart Disease  Commentary: What Matters More—Method of Revascularization or Completeness?  Gender Representation Among Speaking and Leader Roles at European Cardiothoracic Surgical Annual Meetings CTSNet Content Mentioned TAVR Explantation: A Necessary Skill Set in the Contemporary Cardiac Surgery's Armamentarium  Redo Pulmonary Vein Stenosis Correction After TAPVR Correction  Deep Dive Into Total Arterial Anaortic Off-Pump Coronary Artery Bypass Grafting: Dual Inflow BIMA In Situ to LAD and RCA  Other Items Mentioned CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the May issue of The Journal of Heart and Lung Transplantation. Digital Media Editor David Schibilsky, MD, a cardiothoracic surgeon from Freiburg, Germany, hosts this episode.   First, Dr. Schibilsky and Digital Media Editor Erika Lease, MD, interview their first guest, Helen A. Hannan, the podcast's first-ever undergraduate pre-medical guest, from the University of Michigan. Helen was the lead author on the study “Racial and Gender Disparities in Transplantation of Hepatitis C+ Hearts and Lungs.” The study noted that prior research in utilization of kidneys from donors with Hepatitis C had shown disparities due to gender and education—and wanted to see if this was the case in heart and lung donors as well.   Drs. Schibilsky and Lease chat with Helen about the findings of the study, including some of the interesting differences shown between heart and lung recipients, and the ramifications for better patient discussions at the clinical level.   Next, Dr. Schibilsky and Digital Media Editor Marty Tam, MD, interview their next guest, Lauren Truby, MD, of the University of Texas Southwestern Medical Center in Dallas. Dr. Truby is the podcast's first return guest, having appeared on the show near the end of 2021. This time, she's featured as first author on the study “Metabolomic profiling during ex situ normothermic perfusion before heart transplantation defines patterns of substrate utilization and correlates with markers of allograft injury.” The paper explores cardiac metabolism of donor hearts during recovery using an ex situ normothermic perfusion system (NRP).   Dr. Truby provides an in depth look at the project's logistics—which she calls a “labor of love”—its multi-point findings, and what's next in this line of research.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

This week on CTSNet's flagship podcast, Editor in Chief Joel Dunning discusses presentations from the SCTS annual meeting on the future of aortic valve replacement surgery and the continued debate among surgeons about the benefits of TAVR versus those of SAVR. In addition, Joel discusses a review of heart valve surgery in resource limited settings, long term outcomes of heart transplantation in adults with congenital heart disease, and intervention for symptomatic moderate aortic stenosis. He also talks about an interview and surgical video with Dr. Lars Svensson, how to position the heart in off-pump CABG, and a lobectomy for a hydatid cyst using uniportal VATS. Before saying goodbye, he discusses upcoming events in CT surgery. JANS Items Mentioned A Global Systematic Review of Open-Heart Valvular Surgery in Resource Limited Settings  Long-term Outcomes of Heart Transplantation in Adults With Univentricular Versus Biventricular Congenital Heart Disease  Great Debate: Symptomatic Moderate Aortic Stenosis Should Undergo Intervention  CTSNet Content Mentioned World's Best United States: Aortic Root Replacement and an Interview With Lars Svensson  Deep Dive Into Total Arterial Anaortic Off-Pump Coronary Artery Bypass Grafting: How to Position the Heart  Right Upper Lobectomy for a Hydatid Cyst Using U-Vats  Other Items Mentioned CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the March issue of The Journal of Heart and Lung Transplantation. Digital Media Editor Marty Tam, MD, an advanced heart failure and transplant cardiologist at University of Michigan in Ann Arbor, hosts this episode.   First, Dr. Tam and Digital Media Editor David Schibilsky, MD interview their first guests, Fiorella Calabrese, MD and Francesca Lunardi, MD, ScD, PhD, of University of Padova, in Padova Italy. Dr. Lunardi was first author and Dr. Calabrese was senior author on the study “Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection.” In the conversation, Drs. Calabrese and Lunardi share the main challenges in the current diagnostic algorithm for AMR in lung transplantation, and why this protein expression may be a future mainstay in evaluating patients with this condition.   Next, Dr. Tam and Digital Media Editor Van-Khue Ton, MD, interview their next guest, Benjamin Mackie, MD, of Tampa General Hospital. Dr. Mackie was senior author on the study “Relationship between blood and tissue-based rejection-related transcripts in heart transplantation.” In the conversation, Dr. Mackie shares the current state of rejection assessment, including new, non-invasive modalities, and how the relation between these diagnostic methods may inform clinical practice.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the February issue of The Journal of Heart and Lung Transplantation. Digital Media Editor Van-Khue Ton, MD, a transplant cardiologist at Massachusetts General Hospital, hosts this episode.   First, Dr. Ton and Digital Media Editor Erika Lease, MD interview their first guest, David Jenkins, FRCS(Cth), of the Royal Papworth Hospital in Cambridge, UK. Dr. Jenkins was senior author on the study “Perioperative extracorporeal membrane oxygenation support for pulmonary endarterectomy: A 17-year experience from the UK national cohort.” In the conversation, Dr. Jenkins shares the major determinants of mortality in this patient population, differences between survivors and non-survivors, and the CTEPH classification systems involved.   Next, Dr. Ton is joined by Digital Media Editor Marty Tam, MD, to interview their next guest, Kevin Chen, a 4th year general surgery resident at Cedars-Sinai Medical Center. Dr. Chen was a first author on the study “Heart transplantation in patients from socioeconomically distressed communities.” Drs. Ton and Tam lead a lively discussion about this important paper, including the methodology behind the indices used to categorize patients, and the million-dollar question: why did patients from distressed communities fare more poorly?   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Welcome to 2024! The JHLT Digital Media Editors kick off the new year with a look back at the best of the best from 2023 – specifically, a few of the guidelines and consensus statements from the International Society for Heart and Lung Transplantation that appeared in The Journal of Heart and Lung Transplantation this past year.   Digital Media Editor David Schibilsky, MD, a cardiothoracic surgeon from Freiburg, Germany, hosts this episode.   First, Digital Media Editor Marty Tam, MD, reviews the updated Heart Transplantation guidelines, published in JHLT at the start of 2023. What's changed in the decade plus since the 2010 guidelines were published? For starters, there's more than 200 new or updated recommendations in this document, and Dr. Tam walks you through some of the highlights.   Next, Digital Media Editor Erika Lease, MD, shares the new reproductive health guidelines for transplant patients—something that's relevant to just about everyone working in the cardiothoracic transplantation space. Dr. Lease steps through this much-needed consensus statement and some of its key takeaways.   Finally, Dr. Schibilsky joins his fellow Digital Media Editor Van-Khue Ton, MD, for a discussion about the MCS guidelines, another 10 year update on a massive—and massively important—document. Drs. Schibilsky and Ton share their favorite parts of the guideline, and do a little imagining about what might be present in the next major update for MCS.   Follow along at www.jhltonline.org/current, or check out all of the ISHLT's Standards and Guidelines documents at https://ishlt.org/publications-resources/professional-resources/standards-guidelines.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

This podcast episode examines the need for and promise of xenotransplantation, considering first the plight of patients and then the progress being made by researchers. . Is Xenotransplantation Ready for Prime Time? N Engl J Med 2023;389:e49.

In our final episode of 2023, the JHLT Digital Media Editors have two manuscripts from the December 2023 issue of The Journal of Heart and Lung Transplantation! Digital Media Editor Erika Lease, MD, transplant pulmonologist at the University of Washington in Seattle, hosts this episode.   First, a free-ranging conversation with first author Mark E. Snyder, MD, and senior author John F. McDyer, MD, on their team's study “Impact of age and telomere length on circulating T cells and rejection risk after lung transplantation for idiopathic pulmonary fibrosis.”   A subset of patients with idiopathic pulmonary fibrosis (IPF) have a heritable, age-adjusted short telomere length. Mutations in telomere length can manifest as T-cell dysfunction and immunodeficiency. As T-cells are involved in the development of acute cellular rejection (ACR), the authors hypothesized that the combination of age and telomere length would impact the degree of ACR burden in lung transplant recipients—and indeed, the authors found that lung transplant recipients with IPF and short telomere length had premature “aging” of their circulating T-Cells. There was a significant decline in early ACR burden with increasing age, found only in those with short telomere length.   How might these findings impact immunosuppression regimens in clinical practice? What follow-up studies to they have planned? In the discussion, Drs. Snyder and McDyer, both of UPMC in Pittsburgh, discuss all these possibilities, as well as the the work of their collaborator, Jonathan K. Alder, PhD, as inspiration for the study.   Next, the editors explored “Early optical coherence tomography evaluation of donor-transmitted atherosclerosis and cardiac allograft vasculopathy: insights from a prospective, single-center study,” in a discussion with senior author Snehal R. Patel, MD, of the Montefiore Medical Center in New York.   Cardiac allograft vasculopathy (CAV) remains a major cause of death in heart transplant recipients, and donor-transmitted atherosclerosis (defined as a maximal intimal thickness of >/= 0.5mm on baseline intravascular ultrasound (IVUS) early after transplant) is believed to carry a greater risk for the development of CAV. Dr. Patel's team, however, hypothesized that optical coherence tomography (OCT) may have advantages over IVUS as an imaging modality due to its higher resolution. In this prospective, observational study, the authors assessed the prognostic role of OCT, and found that transplant recipients whose OCT imaging showed advanced plaque characteristics had a significantly higher event rate after a mean follow up of 3.3 years. OCT was also an independent predictor of clinic events, while maximal intimal thickness of >/= 0.5mm was not.   In the episode, Dr. Patel shares the key features of OCT that may make it of clinical use, the three risk categories developed for the study, and what the follow-ups might be.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

Drs Michelle Kittleson and James Fang cap off the podcast series by discussing difficult cardiac transplantation decision points, including LVADs and the latest innovations in cardiac transplantation. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/982166). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Heart Failure https://emedicine.medscape.com/article/163062-overview Heart Transplantation https://emedicine.medscape.com/article/429816-overview Lynne Warner Stevenson, MD, FHFSA https://hfsa.org/lynne-warner-stevenson-md-fhfsa Risk Prediction Models for Survival After Heart Transplantation: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/31733026/ Evaluation for Heart Transplantation and LVAD Implantation https://njadvancedheartfailure.com/wp-content/uploads/2022/04/Zucker-Heart-Transplantation-and-LVAD-Indications.pdf Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/30852913/ Left Ventricular Assist Devices https://www.ncbi.nlm.nih.gov/books/NBK499841/ The Burden of Haemocompatibility With Left Ventricular Assist Systems: A Complex Weave https://pubmed.ncbi.nlm.nih.gov/28329374/ Guidance and Policy Clarifications Addressing Adult Heart Allocation Policy https://optn.transplant.hrsa.gov/media/3931/guidance_policy_clarifications_address_adult_heart_allocation_policy.pdf Heart Transplantation From Donation After Circulatory Determined Death https://pubmed.ncbi.nlm.nih.gov/29492385/ Destination Therapy With Left Ventricular Assist Devices in Non-Transplant Centres: The Time Is Right https://pubmed.ncbi.nlm.nih.gov/32419850/ Frailty and the Selection of Patients for Destination Therapy Left Ventricular Assist Device https://pubmed.ncbi.nlm.nih.gov/22438521/ Heart Transplant Advances: Ex Vivo Organ-Preservation Systems https://pubmed.ncbi.nlm.nih.gov/36004090/ First Clinical Experience With the Novel Cold Storage Sherpapak™ System for Donor Heart Transportation https://pubmed.ncbi.nlm.nih.gov/33447411/ Is the Organ Care System (OCS) Still the First Choice With Emerging New Strategies for Donation After Circulatory Death (DCD) in Heart Transplant? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229932/

In this special issue of JHLT: The Podcast, the JHLT Digital Media Editors explore just one study—and devote the second half of the episode as a tribute to recently retired Editor-in-Chief, Dr. Daniel R. Goldstein. Digital Media Editor Van-Khue Ton, MD, heart failure and transplant cardiologist at Massachusetts General Hospital, hosts this episode.   First, hear from senior author William F. Parker, MD, MS, PhD, on his team's study “Association of high-priority exceptions with waitlist mortality among heart transplant candidates.” Dr. Parker is a pulmonary and critical care physician, health services researcher, and clinical medical ethicist, and he runs a R01 funded lab focusing on the allocation of scarce healthcare resources.   In the study, Dr. Parker and colleagues set out to examine the Scientific Registry of Transplant Recipients (SRTR) to compare medical urgency of heart transplant patients listed with exception vs. those listed according to standard guidelines. The study's main finding: after controlling for status as a time-varying covariate, candidates with an exception had a 45% lower hazard of waitlist mortality compared with standard criteria candidates. The Digital Media Editors want to know all the details and talk with Dr. Parker about the wait-list mortality and post-transplant survival of status 1, 2, 3, and 4 candidates, plus what next steps could be in ensuring a fair allocation system.   The episode's special tribute to Dr. Daniel R. Goldstein features Michelle Kittleson, MD, PhD, Interim Editor-in-Chief of JHLT; Andrew Gelman, PhD, Deputy Editor at JHLT; Andrew Fisher, FRCP, PhD, past president of ISHLT and Chair of the Publications Oversight Committee; Daniel Tyrrell, PhD, a former post-doc of Dr. Goldstein's; and Judy Chen, PhD, a former immunology PhD student in Dr. Goldstein's lab.   These heartfelt tributes to Dr. Goldstein are worth a listen—and we thank Dr. Goldstein for his vision and leadership at the Journal.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

Today, you'll learn about a new study on our perception of time, a breakthrough in the tech behind heart transplants, and about the crazy way ticks fly.Find episode transcripts here: https://curiosity-daily-4e53644e.simplecast.com/episodes/time-perception-heart-in-a-box-flying-ticksTime Perception“The Timekeeper Within: New Discovery on How the Brain Judges Time.” by Hedi Young. 2023.https://www.fchampalimaud.org/news/timekeeper-within-new-discovery-how-brain-judges-time“Using temperature to analyze the neural basis of a time-based decision.” by Tiago Monteiro, et al. 2023.https://www.nature.com/articles/s41593-023-01378-5Heart in a Box“Multicenter Trial Finds Using Circulatory Death Donors is Safe and Effective for Heart Transplantation.” n.a. 2023.https://news.feinberg.northwestern.edu/2023/06/14/multicenter-trial-finds-using-circulatory-death-donors-is-safe-and-effective-for-heart-transplantation/“Transplantation Outcomes with Donor Hearts after Circulatory Death.” by Jacob N. Schroder, M.D. 2023.https://www.nejm.org/doi/full/10.1056/NEJMoa2212438“Establishing the new standard of care for organ transplantation.” TransMedics Website. N.d.https://www.transmedics.com/Flying Ticks“Ticks Fly Through the Air Via the Power of Static Electricity.” by Christie Wilcox. 2023.https://www.science.org/content/article/watch-ticks-fly-through-air-power-static-electricity“Static electricity passively attracts ticks onto hosts.” by Sam J. England, et al. 2023.https://www.cell.com/current-biology/fulltext/S0960-9822(23)00772-8?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S0960982223007728?showall%3Dtrue“Tick-borne Diseases.” Washington State Department of Health. N.d.https://doh.wa.gov/you-and-your-family/illness-and-disease-z/tick-borne-diseases“Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014-2016.” CDC. 2022.https://wwwnc.cdc.gov/eid/article/28/6/21-1335_article“Guide to Tick-Borne Diseases.” Nayana Ambardekar, MD. 2021.https://www.webmd.com/skin-problems-and-treatments/ss/tick-borne-diseasesFollow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.

Heart transplantation is a chance at life for patients. Natalie Salvatore, RN, interviews Eileen Hsich, MD, Medical Director for the Heart Transplant Program at Cleveland Clinic, about caring for patients who might require heart transplantation, next steps if they are not a candidate and her biggest piece of advice.

The JHLT Digital Media Editors explore two manuscripts from the August issue of The Journal of Heart and Lung Transplantation—the first on immunosuppression in pediatric heart transplantation, and the second TA-NRP in DCD lung transplantation. Digital Media Editor Van-Khue Ton, MD, heart failure and transplant cardiologist at Massachusetts General Hospital, hosts this episode.   First, hear from senior author Steven C. Greenway, MSc, MD, on his team's study “Single-drug immunosuppression is associated with noninferior medium-term survival in pediatric heart transplant recipients.” Dr. Greenway shares his journey from enzyme biochemistry in mollusks, snails, and frogs to pediatric cardiology, then outlines the results of the paper.   The study queried the Pediatric Heart Transplant Society's registry to determine the efficacy and safety of monotherapy immunosuppression. The results showed better graft survival and less coronary allograft vasculopathy in the monotherapy group, even after adjusted for age at transplant, sex, neonatal transplant, infection, PTLD, and etiology of cardiomyopathy. Dr. Greenway and the digital media editors discuss the burning questions that obviously arise from the study's findings, the limitations of the paper, and what follow-up studies might start generating the answers that might eventually change clinical practice.   Next, the editors welcome first author Jad Malas, MD, to discuss the paper “The impact of thoracoabdominal normothermic regional perfusion on early outcomes in donation after circulatory death lung transplantation.” This study utilized the United Network of Organ Sharing (UNOS) database to identify DCD donors whose heart was procured in order to evaluate lung utilization rates and early post-lung transplant outcomes. Lung utilization was similar between the groups—14.9% for the NRP group and 13.8% for direct procurement. Post-lung transplant rates of ECMO and mechanical ventilation at 72 hours were not statistically different, and 6-month survival was equivalent.   Dr. Malas and the Digital Media Editors discuss the study's findings and implications, including exploring the background of NRP's relationship to lung allografts, differences in assessment or procurement techniques, and what might be needed to further evaluate this procurement technique for lung allografts.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.   This episode of JHLT: The Podcast, but not the studies within, is sponsored by Natera.

The JHLT Digital Media Editors explore two manuscripts from the July issue of The Journal of Heart and Lung Transplantation—one on heart transplantation and one on lung transplantation. Digital Media Editor Marty C. Tam, MD, Assistant Professor at the University of Michigan, hosts this episode.   First, hear from co-first author Kevin Chen, MD, on his team's study “Donation after circulatory death heart procurement strategy impacts utilization and outcomes of concurrently procured abdominal organs,” which comes from Cedars-Sinai. The study looks into the results of DCD organ donation depending on the technique used at procurement, mainly comparing ex-situ normothermic organ perfusion with thoracoabdominal normothermic regional perfusion (TA-NRP).   Digital Media Editors David Schibilsky, MD, and Van-Khue Ton, MD, have questions on the relationship between DCD liver and kidney procurement and heart procurement strategies, why TA-NRP livers and kidneys might differ, and the lower incidence of delayed graft function in DCD kidney transplants with TA-NRP. Dr. Chen also shares some thoughts about how this work might be incorporated into clinical practice.   Next, the editors welcome first author Jonathan P. Singer, MD, MS, from UCSF, to discuss the paper “Development of the Lung Transplant Frailty Scale (LT-FS).” Based on previous work, Dr. Singer and his colleagues set out to develop a novel frailty scale specifically for lung transplant candidates with improved performance characteristics over other frailty scales. The authors developed three lung transplant frailty measures and compared the construct and predictive validity to the existing short physical performance battery (SPPB) and the fried frailty phenotype (FFP). Their LT-FS models exhibited superior construct and predictive validity to these measures—and the addition of muscle mass and biomarkers further improved the model's performance.   Digital Media Editor Erika Lease, MD, digs in with Dr. Singer on the main findings of the study. What's unique about patients with advanced lung disease that makes them need a more specific frailty scale? How does the LT-FS outshine prior models? And what are the barriers to implementing a new model like this one in a transplant center?   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

In this week's episode, we delve into the world of pediatric heart transplantation and the impact that race or insurance status may have on outcomes. What are the factors that explain worse outcomes for black children waiting for a heart transplant? How is the PHTS Racial Disparity Taskforce working to reduce inequities in this field? What role does insurance status have on these outcomes? We speak with noted heart failure and transplantation expert, Dr. Neha Bansal who is Assistant Professor of Pediatrics at The Icahn School of Medicine at Mount Sinai about this most recent PHTS multicenter study. DOI: 10.1016/j.healun.2022.12.002

On the June episode of JHLT: The Podcast, the Digital Media Editors explore two manuscripts from the June issue of The Journal of Heart and Lung Transplantation, with authors from the US and Denmark.   First, hear from senior author Steven R. Hays, MD, on his team's study “Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function,” which explores digital health and comes out of UCSF. In the study, the authors developed an automated digital health intervention using Bluetooth-enabled home spirometers to monitor for complications after lung transplantation. Using a chat-based application, patients could perform home spirometry, answer symptom queries, and receive patient education. The program could also alert both the patient and center providers to substantial decreases in FEV1 from baseline—and any other concerning symptoms.   Dr. Hays and Digital Media Editors Erika Lease, MD, and Van-Khue Ton, MD, PhD, discuss how COVID-19 created a serendipitous moment to fund the study, and some of the most valuable lessons from the rollout of the program, including creating efficiencies among the transplant team, proper resourcing, and next steps for perfecting the program.   Next, the editors welcome first author Niels Moeslund, MD, PhD, from Aarhus University in Denmark, to discuss the paper, “Ex-situ oxygenated hypothermic machine perfusion in donation after circulatory death heart transplantation following either direct procurement or in-situ normothermic regional perfusion.” In the study, authors set out to explore the use of oxygenated hypothermic machine perfusion as an alternative to in-situ normothermic regional perfusion or ex-situ normothermic machine perfusion of DCD hearts. They used a porcine model to simulate a DCD setting, and performed either normothermic regional perfusion and static cold storage; normothermic regional perfusion with hypothermic machine perfusion with the XVIVO heart preservation system; or direct procurement with hypothermic machine perfusion—all before heart transplantation was performed.   Digital Media Editor David Schibilsky, MD, digs in with Dr. Moeslund on the main findings of the study, in which HMP hearts showed better contractility after transplantation despite significantly lower inotropic support. Why? Dr. Moeslund shares that the hypothermia of HMP keeps metabolic activity low while myocytes are being replenished, creating maximum potential for energy restoration.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

With Interviewee: Doctor Tuvia Ben Gal, Rabin Medical Center, Petah Tikva, Israel and Interviewer: Doctor Cornelia Margineanu, Emergency Institute of Cardiovascular Diseases Prof. Dr. C.C. Iliescu, Bucharest, Romania. In this podcast, Dr Cornelia Margineanu from Bucharest, Romania interviews professor Tuvia Ben Gal from Petah Tikva, Israel on cardiac transplantation. Throughout the podcast, the expert shares a wealth of knowledge, drawing from years of experience and expertise in the field regarding indications, outcomes, specific management and also, valuable practical advice.

ESC TV Today brings you concise analysis from the world's leading experts, so you can stay on top of what's happening in your field quickly. This episode covers: Cardiology This Week: A concise summary of recent studies Diagnostic workup of cardiac sarcoidosis LVAD and heart transplantation as treatment options in advanced heart failure Snapshots Host: Rick Grobbee Guests: Stephan Achenbach, Ron Blankstein and Finn Gustafsson Want to watch that episode? Go to: https://esc365.escardio.org/event/1037   Disclaimer This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC.   Declarations of interests Stephan Achenbach, Ron Blankstein, Rick Grobbee and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, Alnylam, Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, Lilly, Novartis, Pfizer, Sanofi, Servier, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Sanofi, Daiichi Sankyo, Terumo, Medtronic, Chiesi. Finn Gustafsson has declared to have potential conflicts of interest to report: advisor: Abbott, Fineheart, Adjucor, Corwave. Emma Svennberg has declared to have potential conflicts of interest to report: institutional research grants from Bayer, Bristol-Myers, Squibb-Pfizer, Boehringer- Ingelheim, Johnson & Johnson, Merck Sharp & Dohme.

On May's JHLT: The Podcast, we feature two manuscripts from the May issue of The Journal of Heart and Lung Transplantation.   First, the editors explore a study entitled “Donor hyperoxia is a novel risk factor for severe cardiac primary graft dysfyunction,” which comes from Kransdorf and colleagues at Cedars Sinai Medical Center in Los Angeles.   The editors welcome first author Evan Kransdorf, MD, PhD, to share how he transitioned from oncology to heart failure and transplantation, and to talk about the findings of the study. The Digital Media Editors want to know how machine learning came to be a part of the study, what other donor-specific predictors might contribute to severe PGD, and whether DCD and DBD donors had different outcomes.   Next, the editors welcome first author Danny Ramzy, MD, PhD, from the UTHealth McGovern School of Medicine in Houston to discuss the paper, “Improved clinical outcomes associated with the Impella 5.5 compared to the Impella 5.0 in contemporary cardiogenic shock and heart failure patients.”   The digital media editors dig in with Dr. Ramzy on why Impella 5.5 has better outcomes and if this outcome holds in multivariable models, why the survival outcomes were so much higher than published survivals for patients with cardiogenic shock, and what follow up studies might get the answers they're looking for.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

El podcast de JHLTenEspañol: presentamos por primera vez un podcast de JHLT en Español, conducido por Marta Farrero, MD, PhD, en el que repasamos 4 artículos destacados de 2022, cada uno centrado en el foco de interés de las redes interdisciplinarias de ISHLT. El artículo sobre soporte circulatorio se titula “La recuperación de la función ventricular se asocia con mejores resultados en asistencia ventricular”, con Cameron Olsen, MD, como primer firmante, y es comentado por el Sebastián Rojas, MD. Se analiza el impacto clínico favorable de la recuperación de la fracción de eyección por encima del 40% en una cohorte retrospectiva de pacientes con implante de asistencia ventricular de larga duración. El artículo sobre trasplante pulmonar se titula “Síndrome del injerto restrictivo vs bronquiolitis obliterante: caracterización inmunológica y molecular de exosomas circulantes”, con Sandhya Bansal, PhD primer firmante, comentado por Alejandro Bertolotti, MD. Este trabajo se propone tratar de caracterizar la patogenia del rechazo crónico analizando el contenido de moléculas proinflamatorias y potencialmente inmunogénicas contenidas en exosomas aislados del plasma de receptore de trasplante pulmonar. El artículo sobre hipertensión pulmonar se titula “Escalas de riesgo y predicción clínica en hipertensión arterial pulmonar, un análisis del freedom-EV” con de Raymond L. Benza, MD como primer firmante y Roberto Bernardo, MD, MS para realizar los comentarios. En este subanálisis se observa como las escalas de riesgo de los pacientes con hipertensión pulmonar mejoran tras la administración de treprostinil oral. El cuarto y último artículo se titula “MicroRNA circulante y rechazo mediado por anticuerpos en el trasplante cardíaco”, con Palak Shah, MD, MS como primer firmante y comentado por Vanessa Blumer, MD. En este trabajo se identificó qué microRNA se asocian a rechazo celular y mediado por anticuerpos, permitiendo hacer el diagnóstico con una buena sensibilidad y especificidad.

It's another COVID-19 special on this month's JHLT: The Podcast, which features two articles on COVID-19 and thoracic organ transplantation from the April issue of The Journal of Heart and Lung Transplantation.   First, the editors explore a study entitled “Heart transplantation for COVID-19 myopathy in the United States,” which comes from Gill and colleagues at Cedars Sinai Medical Center in Los Angeles.   The editors welcome first author George Gill, MD, to share what brought him from the United Kingdom to the States, and to talk about the findings of the study. The Digital Media Editors want to know how COVID-19 myocarditis impacts immune response in transplantation, how Dr. Gill manages different etiologies of cardiomyopathy, and some of the limitations of the study.   Next, the editors welcome senior author Nicolaus Schwerk, MD, from Hannover Medical School in Germany to discuss the paper, “COVID-19 in pediatric lung transplant recipients: Clinical Course and outcome.”   Dr. Schwerk is an expert in rare diffuse parenchymal lung diseases and end stage lung diseases, as well as congenital thoracic malformations in children, and performs lung transplantation. This single-center study investigated the impact of SARS-COV-2 infection on pediatric lung transplant recipients between March 2020 and June 2022 at Hannover Medical Center. The key finding of the study was that the COVID-19-positive pediatric lung transplant recipients did remarkably well.   The digital media editors dig in with Dr. Schwerk on the pace of COVID-19 infections in Europe, why antivirals are used differently in pediatric patients, and why pediatric patients typically experience a more mild course of disease.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

Hundreds of thousands of people in the U.S. are receiving treatment for failing kidneys, livers, hearts, and other organs. Learn about the current strategies and new advances to support, provide organs and solutions to those in need. In this program, Dr. Jason Smith discusses the process for determining when to perform a heart transplant after death. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38490]

Hundreds of thousands of people in the U.S. are receiving treatment for failing kidneys, livers, hearts, and other organs. Learn about the current strategies and new advances to support, provide organs and solutions to those in need. In this program, Dr. Jason Smith discusses the process for determining when to perform a heart transplant after death. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38490]

Hundreds of thousands of people in the U.S. are receiving treatment for failing kidneys, livers, hearts, and other organs. Learn about the current strategies and new advances to support, provide organs and solutions to those in need. In this program, Dr. Jason Smith discusses the process for determining when to perform a heart transplant after death. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38490]

Hundreds of thousands of people in the U.S. are receiving treatment for failing kidneys, livers, hearts, and other organs. Learn about the current strategies and new advances to support, provide organs and solutions to those in need. In this program, Dr. Jason Smith discusses the process for determining when to perform a heart transplant after death. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38490]

Hundreds of thousands of people in the U.S. are receiving treatment for failing kidneys, livers, hearts, and other organs. Learn about the current strategies and new advances to support, provide organs and solutions to those in need. In this program, Dr. Jason Smith discusses the process for determining when to perform a heart transplant after death. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38490]

Hundreds of thousands of people in the U.S. are receiving treatment for failing kidneys, livers, hearts, and other organs. Learn about the current strategies and new advances to support, provide organs and solutions to those in need. In this program, Dr. Jason Smith discusses the process for determining when to perform a heart transplant after death. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 38490]

Dr Ruqaiah Altassan describes the successful heart transplantation in a child with PGM1-CDG. Successful heart transplantation in an infant with phosphoglucomutase 1 deficiency (PGM1-CDG) Ruqaiah Altassan, et al https://doi.org/10.1002/jmd2.12350 You may also be interested in: AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase I deficiency (PGM1-CDG). Balakrishnan et al https://www.sciencedirect.com/science/article/abs/pii/S193152442300004X?via%3Dihub

This month on JHLT: The Podcast, the JHLT Digital Media Editors review two studies from the February issue of The Journal of Heart and Lung Transplantation—and bring in a couple of experts to help them make sense of some new technology.   First, the editors explore a pre-clinical study entitled “The dynamic cellular landscape of grafts with acute rejection after heart transplantation,” which comes from Kong and colleagues at Zhejiang University in Hangzhou, China.   Single cell technologies are emerging as non-biased techniques to discover novel biological pathways in a variety of pre-clinical models and in human tissue both in health and disease. To help the editors—and you!—understand single cell approaches and this study, JHLT editors Ben Kopecky, MD, PhD and Kory Lavine, MD, PhD, from the Washington University St. Louis, appear in the episode to explore the methodology and what the study tells us.   Second, the editors welcome author Sam Rayner, MD from the University of Washington in Seattle, USA, to discuss the paper by Hirsch and colleagues, “Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.”   When considering differences in pathophysiology of the subtypes of PAH, changes in biomarkers in angiogenesis and inflammation may provide useful insights and potential therapeutic targets. The authors of this study prospectively looked at 33 biomarkers of angiogenesis and inflammation in a cohort of patients across various PAH etiologies, and made correlations to clinical outcomes.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

This week we delve into the world of partial heart transplantation when we review a recent paper that discusses the rationale for its potential use in children, particularly in infants. We speak with the work's senior author, Dr. T. Konrad Rajab of the Medical University of South Carolina about the potential benefits of this approach. Who might be a candidate for this approach? What are the theoretical benefits of this approach to transplantation? How many 'partial heart' transplantations have been done to date in the US? What might be different about transplanting 'parts' of hearts rather than entire hearts? Dr. Rajab provides us with his deep insights this week. doi: 10.1111/jocs.17050

JHLT: The Podcast kicks off 2023 with a look back at 2022. Daniel R. Goldstein, MD, Editor-in-Chief of JHLT, joins the JHLT Digital Media Editors for a recap of the past year of The Journal of Heart and Lung Transplantation.   Studies include: Pérez-Carrillo, et al, “Diagnostic value of serum miR-144-3p for the detection of acute cellular rejection in heart transplant patients.” Feb 2022 JHLT Han, et al, “Impact of using higher-risk donor hearts for candidates with pre-transplant mechanical circulatory support.” Feb 2022 JHLT Jackson, et al, “Heart transplant outcomes in cardiac sarcoidosis.” Jan 2022 JHLT Ribeiro, et al, “Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.” Mar 2022 JHLT Moshkelgosha, et al, “Interferon-stimulated and metallothionein expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation.” Nov 2022 JHLT   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

This month on JHLT The Podcast, JHLT Digital Media Editor Marty Tam, MD, takes over hosting duties to present two papers from the December issue of The Journal of Heart and Lung Transplantation. Listen now to hear study authors discuss their work, their studies, and next steps for their research. First, we welcome first author Jorge V. López-Ibor, MD, and senior author Javier Segovia-Cubero, MD, PhD, about their team's study from Hospital Universitario Puerto de Hierro Majadahonda entitled “Role of TGF-β1 +869T>C polymorphism in renal dysfunction one year after heart transplantation.” Drs. López-Ibor and Segovia-Cubero share some background on their work and their areas of research before diving into the study. The study analyzed 355 adult patients for renal dysfunction a year post-heart transplant and suggested a protective role for the TGF- β1 + 869CC genotypes in the development of chronic kidney disease (CKD) in heart transplant patients on calcineurin inhibitors (CNIs). Next, Tsuyoshi Takahashi, MD, PhD, from Washington University, shares details on the study “A comparison of outcomes after lung transplantation between European and North American centers.” Dr. Takahashi begins by discussing his global journey in thoracic surgery, including some of the differences between being a surgeon in the United States and Japan. The study used the ISHLT Thoracic Organ Registry to complete a retrospective, comparative cohort analysis of adult patients undergoing deceased donor lung transplant in North America and Europe between January 2006 and December 2016. It compared overall survival between North American and European transplant centers in a propensity score matched analysis, suggesting a higher 5-year survival for European centers. Dr. Takahashi answers questions about the many factors contributing to these variances. Follow along in the December issue at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org. This episode of JHLT: The Podcast, but not the studies within, is sponsored by Enzyvant.

This month on JHLT The Podcast, JHLT Digital Media Editor Van-Khue Ton, MD, takes over hosting duties to present two unique papers from the November issue of The Journal of Heart and Lung Transplantation. Listen now to hear study authors discuss their work, their studies, and next steps for their research. First, we welcome first author Megan M. Collins, MD, about her team's study from the University of Utah entitled “Attitudes & practices surrounding pregnancy post heart transplantation among pediatric providers.” Dr. Collins shares her journey from being an undergraduate economics major to her current career in pediatrics, including how strategy and game theory have helped her better understand her patients and thrive during her pediatric cardiology fellowship. The study itself is exceptionally important as more pediatric heart transplant recipients reach adulthood and become interested in family planning. The study consisted of confidential and voluntary web surveys of pediatric heart transplant doctors, exploring their behaviors and policies around pregnancy and family planning. Next, R. James White, MD, from the division of Pulmonary and Critical Care Medicine at the University of Rochester Medical Center, shares details on the study “Contemporary Risk Scores Predict Clinical Worsening in Pulmonary Arterial Hypertension – An Analysis of FREEDOM-EV.” Dr. White is the senior author on the study, and discusses how he became interested in risk scores for pulmonary arterial hypertension, including some of the exciting data that they reveal. Prior to this study, none of the event-driven trials in PAH had previously incorporated serial assessment of risk scores like hemodynamics, laboratory values, exercise tolerance, and symptoms at baseline. Using data from the FREEDOM-EV trial, the study retrospectively compared the discriminant power of 4 risk scores, REVEAL 2.0, REVEAL Lite 2, 4-strata COMPERA 2.0, and the non-invasive French risk assessment, in predicting patients' clinical worsening at baseline and at a 12-week follow up. You won't want to miss Dr. White's insights on this comparison! Follow along in the November issue at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org. This episode of JHLT: The Podcast, but not the studies within, is sponsored by Altavant Sciences.

For this month's episode, JHLT The Podcast explores two impactful studies from the October issue of The Journal of Heart and Lung Transplantation. The episode is hosted by Daniel R. Goldstein, MD, Editor-in-Chief of JHLT, who is joined by the JHLT Digital Media Editors. Listen now to hear study authors discuss their work, their studies, and next steps for their research. First, the editors speak with first author Michael Harhay, PhD (pictured left) and senior author Edward Cantu, MD (pictured right), about their study from the University of Pennsylvania entitled “Epidemiology, risk factors and outcomes of lung retransplantation: an analysis of the ISHLT Transplant Registry.” Dr. Goldstein and Erika Lease, MD, interview Drs. Harhay and Cantu about the study. The objective of the study was to leverage the ISHLT Thoracic Transplant registry using an updated cohort of patients that underwent lung retransplantation to obtain an updated summary of the epidemiology of lung retransplantation; to examine the importance of the time between primary transplantation and retransplantation on outcomes after retransplantation; and to identify risk factors of mortality following lung retransplantation. Next, we hear from Anne Dipchand, MD (pictured), Professor of Pediatrics and Pediatric Cardiologist at the Hospital for Sick Children in Toronto, Canada, who is senior author on the study, “Eplet matching in pediatric heart transplantation: The SickKids experience.” Dr. Goldstein and David Schibilsky, MD, discuss the study with Dr. Dipchand. This single-center retrospective study measured allograft survival in 77 patients while performing HLA typing, antigen mismatch, and eplet mismatch analysis, with the goal of comparing the molecular level HLA matching with antigen level HL matching in post-heart transplant outcomes in children. Follow along in the October issue at www.jhltonline.org/current, or, if you're an ISHLT member, log in at ishlt.org/journal-of-heart-lung-transplantation.  Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Commentary by Dr. Valentin Fuster

This week we review an important report on possible racial disparities amongst children on waiting lists for heart transplantation in the US. How did the 2016 changes to the Organ Procurement and Transplantation Network criteria for listing impact outcomes in listed children and unexpectedly widen racial disparities? What impact did these changes have on mortality and outcomes for white vs. non-white children? Why were differences observed? Dr. Mujeeb Zubair of Cedar-Sinai Medical Center in Los Angeles, CA and Dr. Kurt Schumacher of C.S. Mott Children's Hospital in Ann Arbor, MI share their insights this week. We also speak briefly with Dr. John Triedman of Harvard University about the upcoming Pedirhythmx conference coming in September to Boston, MA. DOI: 10.1161/CIRCULATIONAHA.122.060223