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Chief Medical Officer at Central DuPage Hospital Dr. Tom Moran joins Bob Sirott to share an update on the cyclosporiasis outbreak and if an aortic tear is detectable ahead of time. He also discusses whether or not a cholesterol pill could be an alternative to statins, a study that focuses on a food that could […]
Today's National Days. Dr Joe Galati on Aortic tears. Machine to shoot down bugs being invented. Brian Jodice on the Florida Step Up for Students scholarship is partnering with the national tax credit to help students and families. See omnystudio.com/listener for privacy information.
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Chris Malaisrie, a Professor of Surgery in the Division of Cardiac Surgery at Northwestern University and an Attending Cardiac Surgeon at Northwestern Medicine, about valve-sparing aortic root replacement techniques. Chapters 00:00 Intro 02:25 TAVR Heart Team Coverage 03:52 JANS 1, TAVR vs SAVR Perspective 10:50 JANS 2, Gene-Edited Transplant Model 13:13 JANS 3, Long-Term Outcomes Atrial Fib 14:31 JANS 4, 147-Minute Drowning Circ Arrest 18:01 Video 1, Double Ann Enlargement Prosth Mis 20:48 Video 2, Reop Aortic Root Reconstruction 22:24 Video 3, Normothermic AA Aneurysm 24:22 Dr. Malaisrie, Aortic Root Replacement 41:42 Closing The conversation covers a wide range of procedures, including the Bentall, Yacoub, and David operations, as well as the Ross procedure and personalized external aortic root support (PEARS). They further explore approaches to mitral and aortic valve repair, the management of diseased leaky valves, and the advantages of the Stanford modification of the David V procedure. Dr. Malaisrie concludes the discussion by offering advice to surgeons on refining their valve repair skills and shares his prediction for the future of valve repair surgery. Joel also highlights recent JANS articles on age vs lifetime perspective on the transcatheter vs surgical aortic valve implantation, gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants, long-term outcomes of postoperative atrial fibrillation after cardiac surgery, and a case on ice water drowning survival after 147-minute submersion and 7 °C hypothermic circulatory arrest. In addition, Joel explores double annular enlargement as an effective technique to overcome patient-prosthesis mismatch, reoperation for aortic root reconstruction, and normothermic treatment of an aortic arch aneurysm. Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned Transcatheter vs Surgical Aortic Valve Implantation: Age vs Lifetime Perspective Gene-Edited Pig Cardiac Xenotransplantation as a Bridge to Allotransplantation in Infants: Progress in a Pig-to-Baboon Model Long-Term Outcomes of Postoperative Atrial Fibrillation After Cardiac Surgery: Results From 19,000 Patients Ice Water Drowning Survival After 147-Minute Submersion and 7 °C Hypothermic Circulatory Arrest CTSNet Content Mentioned Double Annular Enlargement as an Effective Technique to Overcome Patient-Prosthesis Mismatch Reoperation for Aortic Root Reconstruction Normothermic Treatment of an Aortic Arch Aneurysm Other Items Mentioned Centers for Medicare & Medicaid Services Database—TAVR Career Center CTSNet Events Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261450851
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261455199
The sudden and tragic passing of Senator Lindsey Graham (R-SC) from an aortic dissection has left many shocked. Kennedy cuts through the "Dr. Google" misinformation to explain the terrifying reality of aortic tears, sharing her own painful family history with the condition. Kennedy Now Available on YouTube:https://link.podtrac.com/kstw_yt Follow on TikTok:https://www.tiktok.com/@kennedy_foxnews Join Kennedy for Happy Hour on Fridays!https://youtube.com/playlist?list=PLWlNiiSXX4BNUbXM5X8KkYbDepFgUIVZj Learn more about your ad choices. Visit podcastchoices.com/adchoices
July 14, 2026 ~ Chris Renwick and Lloyd Jackson discuss aortic dissections with Dr. Alessandro Vivacqua, explaining the risks and silent nature of this life-threatening heart condition, plus news on a bison attack. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.
WBEN's Tom Puckett on aortic tears and how they might happen full 56 Tue, 14 Jul 2026 08:00:00 +0000 tF5VgohnTh4gaBNRxRQbIqdG7DUKP0AH news & politics,news WBEN Extras news & politics,news WBEN's Tom Puckett on aortic tears and how they might happen Archive of various reports and news events 2024 © 2021 Audacy, Inc. News & Politics News https://player.amperwavepodcasting
Kaleida Health's Dr. Linda Harris on aortic tears full 302 Tue, 14 Jul 2026 07:10:00 +0000 H4M45v9VKJviW9qx8v8fpAFIk85XgYRN news & politics,news WBEN Extras news & politics,news Kaleida Health's Dr. Linda Harris on aortic tears Archive of various reports and news events 2024 © 2021 Audacy, Inc. News & Politics News https://player.amperwavepodcasting.com?feed-l
Smart Aortic Valve With Pacemaking Capabilities
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Isaac George, CTSNet Board Member and Co-Director of the Structural Heart and Valve Center, Surgical Director of Structural Heart Disease, and Co-Director of the Mitral and Tricuspid Center at Columbia University Medical Center/NewYork-Presbyterian, NY, USA, about the lifetime management of aortic valve disease. Chapters 00:00 Intro 02:11 AATS-CTSN Randomized Trials 04:37 JANS 1, Consensus Statement ALAD 10:28 JANS 2, Lung Re-Transplantation Outcomes 12:19 JANS 3, Aortic Homografts, EURECAH 15:15 JANS 4, Lobectomy Cost Analysis 18:10 Video 1, Anomalous L Coronary Artery 19:38 Video 2, Pulm Valve Replacement Reop 21:38 Video 3, Giant Pulm Artery Aneurysm 23:28 Dr. George Discussion 33:18 Upcoming Events 34:05 Closing They explored the expansion of transcatheter aortic valve replacement (TAVR), emphasizing the crucial role of the heart valve team in this process. The discussion highlighted the necessity for surgeons to be actively involved in the decision-making process surrounding TAVR, particularly in the early stages. They also addressed the importance of lifetime management of the valve, selecting the appropriate valve, and valve durability. Additionally, they discussed the significance of providing patients with multiple surgical options, the Ross procedure, mechanical valves, and explored which procedures patients are choosing. Joel also highlights recent JANS articles on the ISHLT consensus statement on acute lung allograft dysfunction, aortic homografts for native and prosthetic aortic valve and root endocarditis, how outcomes after lung re-transplantation for restrictive allograft syndrome have not improved over two decades, and the financial burden of postoperative adverse events following lobectomy. In addition, Joel explores the surgical repair of an anomalous left coronary artery from the right pulmonary artery, minimally invasive pulmonary valve replacement in reoperative settings, and surgical management of giant pulmonary artery aneurysm using a T-shaped graft-valve strategy. Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned ISHLT Consensus Statement on Acute Lung Allograft Dysfunction (ALAD): Definition, Etiology, Diagnostic and Therapeutic Approaches, and Research Priorities Aortic Homografts for Native and Prosthetic Aortic Valve and Root Endocarditis: Results From the EUropean REgistry of Cryopreserved Aortic Homografts EURECAH Outcomes After Lung Re-Transplantation for Restrictive Allograft Syndrome Have Not Improved Over Two Decades Financial Burden of Postoperative Adverse Events Following Lobectomy: Cost Analysis From 10 High-Volume Canadian Hospitals CTSNet Content Mentioned Surgical Repair of an Anomalous Left Coronary Artery From the Right Pulmonary Artery Minimally Invasive Pulmonary Valve Replacement in Reoperative Settings Surgical Management of Giant Pulmonary Artery Aneurysm Using a T-Shaped Graft-Valve Strategy Other Items Mentioned CTSNet Innovation Video Competition Career Center CTSNet Events Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Morning Glory With Huia! Today Huia had Aortic come in for Fancy New Band who played their new single ! Thank you to NZ On Air! Thank you to The Tuning Fork!
Huia had Aortic come in for Fancy New Band today! Aortic smashed out an awesome set of experimental, genre merging, alternative rock tunes! Thanks to NZ On Air!
LBCT: Four-year Hemodynamic Outcomes with An Intra-annular, Self- Expandable Transcatheter Aortic Valve
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Bo Yang, a cardiovascular and thoracic surgeon at the University of Michigan Health in Ann Arbor, Michigan, USA, about aortic root enlargement. Chapters 00:00 Intro 02:37 JANS 1, WhatsApp for Patients 08:27 JANS 2, DCD Heart Transplant 11:07 JANS 3, TIGHT K Trial 13:18 JANS 4, RecoverHeart Calculator 15:57 Video 1, Self Constructed Valve 18:52 Video 2, MVR Sandwich Technique 20:43 Video 3, Distal Coronary Anastomosis Podcast 23:04 Dr. Yang, Annular Enlargement 36:31 Upcoming Events 37:26 Closing They explored Dr. Yang's participation in a debate regarding the use of aortic root enlargement for the majority of patients, addressing the opposing views against root enlargement and discussing the percentage of patients who undergo this procedure. The conversation also covered important topics such as the mean gradient dropping and the lifelong management of aortic valve disease. They emphasize the importance of maximizing the initial valve size for optimal outcomes. Additionally, Dr. Yang shared insights on his Y-incision technique, highlighting its advantages and effectiveness. They also examined whether this technique increases the length of the surgical procedure. Joel also highlights recent JANS articles on exploring the use of instant messaging groups in the postoperative period for pectus excavatum patients, a multicenter retrospective study comparing DCD heart transplantation in Europe and the United States, six-month outcomes of a trial of potassium supplementation thresholds after cardiac surgery, and determining the individualized probability of myocardial recovery. In addition, Joel explores self-constructed tubular heart valve using bovine pericardium for surgical treatment of tricuspid valve endocarditis, mitral valve repair using the sandwich technique for symmetrical bileaflet prolapse, and an episode of The Atrium podcast featuring host Dr. Alice Copperwheat speaking with Dr. Elan Burton about distal coronary anastomosis. Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned Exploring the Use of Instant Messaging Groups in the Postoperative Period for Pectus Excavatum Patients A Comparison of DCD Heart Transplantation in Europe and the United States: A Multi-Centre, Retrospective Study Six-Month Outcomes of a Trial of Potassium Supplementation Thresholds After Cardiac Surgery Determining the Individualized Probability of Myocardial Recovery: The Multicenter RecoverHeart Calculator CTSNet Content Mentioned Self-Constructed Tubular Heart Valve Using Bovine Pericardium for Surgical Treatment of Tricuspid Valve Endocarditis Mitral Valve Repair Using the Sandwich Technique for Symmetrical Bileaflet Prolapse The Atrium: Distal Coronary Anastomosis Other Items Mentioned Career Center CTSNet Events Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Andrea Steely, an Assistant Professor of Cardiac Surgery in the Division of Cardiothoracic Surgery at the University of Utah Health, Salt Lake City, UT, USA, about aortic surgery and long-term patient follow-up. Chapters 00:00 Intro 01:43 New CTSNet Website 02:36 AATS 2026 09:15 EJCTS News 10:15 Video 1, Left Ventriculotomy 10:51 Video 2, 3-Vessel TECAB 12:24 Video 3, AV Disease in Young Patients 13:14 Andrea Steely, Aortic Surgery & Follow-Up 29:14 Upcoming Events They discussed the critical importance of educating both patients and surgeons about aortic disease, and the most effective strategies for follow-up care after aortic surgery. The conversation also covered testing genetic factors and stabilizing the aortic arch. They also explored reintervention and the importance of a multidisciplinary follow-up approach. Additionally, they addressed topics such as lung cancer screening, the training of non-MDs to evaluate screening charts, and the development of an aortic pathology sheet for each patient. In addition, Joel explores an underutilized approach for closing multiple apical ventricular septal defects, robotic-assisted three-vessel minimally invasive coronary artery bypass, and a presentation from Emile Bacha on the "Surgical Management of Aortic Valve Disease in Young Patients." Before closing, Joel highlights upcoming events in CT surgery. CTSNet Content Mentioned 1. Left Ventriculotomy: An Underutilized Approach for Closing Multiple Apical Ventricular Septal Defects 2. Robotic-Assisted Three-Vessel Minimally Invasive Coronary Artery Bypass 3. SCTS 2026 | Surgical Management of Aortic Valve Disease in Young Patients Other Items Mentioned 1. How to Navigate the New CTSNet Website 2. Career Center 3. CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
LBCT: Repeat Intervention After Failed Transcatheter Aortic Valve Implantation (TAVI): Outcomes of Redo TAVI Versus Surgical Explantation
This episode covers: Cardiology This Week: A concise summary of recent studies Genetics and genetic testing in HCM Asymptomatic aortic valve stenosis Statistics Made Easy: Mediation analysis Host: Wilfried Mullens Guests: JP Carpenter, Caroline Coats, Marc Dweck Want to watch that episode? Go to: https://esc365.escardio.org/event/2564 Want to watch that extended interview on asymptomatic aortic valve stenosis, go to: https://esc365.escardio.org/event/2564?resource=interview Disclaimer ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. ESC TV Today uses a range of tools and resources (including AI) to support content production. All content is reviewed and approved by the editorial team. Statements and opinions expressed by guest speakers are their own. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Antonio Greco and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. Caroline Coats has declared to have potential conflicts of interest to report: in the last 5 years, consultant/advisor to Bayer, Bristol Myers Squibb, Cytokinetics, Sanofi, Roche Diagnostics. Marc Dweck has declared to have potential conflicts of interest to report: consultancy fees from Novartis, Silence, and AstraZeneca related to aortic stenosis and development of a medical therapy. David Duncker has declared to have potential conflicts of interest to report: lecture honoraria from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientifics, Bristol Meyers Squibb, CVRx, Daiichi Sankyo, Medtronic, Microport, Pfizer, Sanofi, Zoll. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.
Host: Wilfried Mullens Guest: Marc Dweck Want to watch that extended interview on https://esc365.escardio.org/event/2564?resource=interview Go to: Want to watch that episode? Go to: https://esc365.escardio.org/event/2564 Disclaimer ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. ESC TV Today uses a range of tools and resources (including AI) to support content production. All content is reviewed and approved by the editorial team. Statements and opinions expressed by guest speakers are their own. Declarations of interests Stephan Achenbach, Yasmina Bououdina, Antonio Greco and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. Marc Dweck has declared to have potential conflicts of interest to report: consultancy fees from Novartis, Silence, and AstraZeneca related to aortic stenosis and development of a medical therapy. David Duncker has declared to have potential conflicts of interest to report: lecture honoraria from Abbott, Astra Zeneca, Biotronik, Boehringer Ingelheim, Boston Scientifics, Bristol Meyers Squibb, CVRx, Daiichi Sankyo, Medtronic, Microport, Pfizer, Sanofi, Zoll. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.
LBCT: Transfemoral J-Valve System for Chronic Aortic Regurgitation: Initial Post-market In-Hospital Experience In 236 Patients
In this podcast, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a large multicenter study evaluating the incidence and clinical significance of aortic regurgitation following mapping and ablation of ventricular arrhythmias in the aortic cusps and commissures. Drawing on contemporary data from four high‑volume centers, the paper provides important reassurance regarding the safety of aortic cusp ablation, demonstrating that clinically significant aortic regurgitation is rare and infrequently progressive. Dr. Marchlinski highlights the key findings, procedural considerations, and implications for everyday practice in ventricular arrhythmia ablation.
In this episode, we'll focus on the final sections of the guideline, which deal with rupture, trauma, and post-operative complications. These are scenarios where decisions are often made under time pressure, evidence is limited, and outcomes can be profoundly affected by organisation of care, experience, and judgement.Guests:Prof. Anders WanhainenDr. Carlota Fernández-Prendes Prof. Athanasios Katsargyris
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261424814
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Frank Tamru, author of Power: A Memoir and owner of Frank Tamru Consultants LLC, about aortic valve technology throughout the years. Chapters 00:00 Intro 01:51 New Website Preparation 02:53 AATS 2026 Overview 11:59 Video 1, Robotic Right-Sided MIDCAB 13:08 Video 2, Extra-Anatomic IAA Repair 14:29 Video 3, Double-Decker Procedure 16:38 Video 4, Aortic Disease Awareness 19:53 Video 5, Robotic Culmen in Situs Inversus 21:30 Frank Tamru, Aortic Valve Technology 35:32 Upcoming Events 36:03 Closing They explored Tamru's professional background and involvement with heart surgeons and cardiovascular leaders. The conversation covered various topics, including heart valves and the evolution of open-heart centers. They also discussed the advancements in aortic valve replacement technologies and the critical role of surgeons as decision-makers in the field. Additionally, Frank shared his experience as the founding publisher of the Asian Cardiovascular and Thoracic Annals. In addition, Joel explores a robotic-assisted right-sided minimally invasive coronary artery bypass for anomalous origin of the right coronary artery, a transdiaphragmatic aorto-supraceliac extra-anatomic bypass for interrupted aortic arch with collateralizations, double-decker procedure for partial anomalous pulmonary venous connection, robotic-assisted right upper segmentectomy (culmen) in situs inversus totalis, and an interview with Gareth Owens and Dr. Ben Youdelman on Think Aorta and aortic disease awareness. Before closing, Joel highlights upcoming events in CT surgery. CTSNet Content Mentioned 1. Robotic-Assisted Right-Sided Minimally Invasive Coronary Artery Bypass for Anomalous Origin of the Right Coronary Artery 2. A Transdiaphragmatic Aorto-Supraceliac Extra-Anatomic Bypass for Interrupted Aortic Arch With Collateralizations 3. Double-Decker Procedure for Partial Anomalous Pulmonary Venous Connection 4. Think Aorta and Aortic Disease Awareness: An Interview With Gareth Owens and Dr. Ben Youdelman 5. Robotic-Assisted Right Upper Segmentectomy (Culmen) in Situs Inversus Totalis Other Items Mentioned 1. Power: A Memoir 2. Website Maintenance Alert! 3. The Lifeline 4. Career Center 5. CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Welcome back to the ESVS Podcasts. This is Suzanne Stokmans, and you are listening to part 2 of the Q&A series on the ESVS 2026 Clinical Practice Guidelines on the Management of Descending Thoracic and Thoraco-Abdominal Aortic Diseases.In this episode, we move from the general principles discussed in part 1 to disease-specific management. We'll focus on acute thoracic aortic syndromes, chronic type B aortic dissection, and degenerative descending thoracic and thoraco-abdominal aortic aneurysms, conditions that make up a large part of daily aortic practice, where decision-making is often nuanced and time-critical.Full names of guests:Prof. Anders WanhainenDr. Carlota Fernández Prendes Prof. Athanasios Katsargyris.
In today's episode, the first of this three-part series, we will discuss the opening section of the guideline: service standards and general considerations. Before moving to specific disease entities or operative strategies, the guideline deliberately starts with the fundamentals — how care should be organised, how patients should be assessed, and which general principles should guide our decision making.Full names of guests:Prof. Anders WanhainenDr. Carlota Fernández Prendes Prof. Athanasios Katsargyris.
In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Dr Jwan Naser from The Mayo Clinic in Rochester, Minnesota, USA. They discuss her study on asymptomatic aortic regurgitation, which suggests it may be less benign than previously believed. If you enjoy the show, please leave us a positive review wherever you get your podcasts. It helps us to reach more people - thanks! Link to published paper: https://heart.bmj.com/content/early/2025/11/17/heartjnl-2025-326643
Commentary by Dr. Jian'an Wang.
Commentary by Dr. Shinichi Shirai.
Commentary by Dr. Jian'an Wang.
With Morton Kern, VA Long Beach and University of California, Irvine, California - USA and Arnold Seto, VA Long Beach and University of California, Irvine, California - USA. Link to European Heart Journal paper Link to European Heart Journal editorial
Host: Darryl S. Chutka, M.D. Guest: George Wang, M.D. Bicuspid aortic valve is a relatively common congenital heart disease. It can be associated with other genetic disorders such as Turner's Syndrome or exist as an isolated entity. In most cases, patients with a bicuspid aortic valve are initially asymptomatic; however later in the course, they may develop symptoms related to a subsequent aortic stenosis or regurgitation. It's also associated with a dilated ascending aorta with potential rupture if unrecognized. Therefore, it's in the patient's best interest to diagnose the condition as early as possible. What are the early symptoms and when should we suspect the patient may have a bicuspid aortic valve? What type of surveillance should be performed and when is surgery indicated? These are some of the questions I'll be asking my guest, Dr. George Wang, a cardiologist in the Department of Cardiovascular Medicine at the Arizona Campus of the Mayo Clinic as we discuss “Bicuspid Aortic Valve Disease”. Mayo Clinic Talks: Heart Health | Mayo Clinic School of Continuous Professional Development Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development
This episode covers: Cardiology This Week: A concise summary of recent studies Lp(a) and aortic valve stenosis The truth about climate change and heart disease Snapshots Host: Emer Joyce Guests: JP Carpenter, Borge Nordestgaard, Hugh Montgomery, Stephan Achenbach Want to watch that episode? Go to: https://esc365.escardio.org/event/2548 Want to watch that extended interview on Lp(a) and aortic valve stenosis, go to: https://esc365.escardio.org/event/2548?resource=interview Disclaimer: ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests: Stephan Achenbach, Yasmina Bououdina and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. Emer Joyce has declared to have potential conflicts of interest to report: Alnylam, Bayer, Pfizer, Fire-1. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Hugh Montgomery has declared to have potential conflicts of interest to report: funded and runs the charity-funded non-profit 'Real Zero'. Unpaid co-chair of the UK Health Alliance on Climate Change, Lancet Countdown on Health and Climate Change. Borge Nordestgaard has declared to have potential conflicts of interest to report: consultancies/talks for AstraZeneca, Sanofi, Ionis, Amgen, Amarin, Novartis, Novo Nordisk, Esperion, Lilly, Arrowhead, Marea, Merck, Torrent, USV – honoraria used for research. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.
Host: Emer Joyce Guest: Borge Nordestgaard Want to watch that extended interview on Lp(a) and aortic valve stenosis, go to: https://esc365.escardio.org/event/2548?resource=interview Want to watch the full episode? Go to: https://esc365.escardio.org/event/2548 Disclaimer: ESC TV Today is supported by Novartis through an independent funding. The programme has not been influenced in any way by its funding partner. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. All declarations of interest are listed at the end of the episode. The ESC is not liable for any translated content of this video. The English language always prevails. Declarations of interests: Stephan Achenbach, Yasmina Bououdina and Nicolle Kraenkel have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, AbbVie, Alnylam, Amgen, AstraZeneca, Bayer, BiAL, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, GSK, Lilly, Novartis, Pfizer, Sanofi, Servier, Takeda, Tecnimede. John-Paul Carpenter has declared to have potential conflicts of interest to report: stockholder MyCardium AI. Davide Capodanno has declared to have potential conflicts of interest to report: Abbott Vascular, Bristol Myers Squibb, Daiichi Sankyo, Edwards Lifesciences, Novo Nordisk, Sanofi Aventis, Terumo. Emer Joyce has declared to have potential conflicts of interest to report: Alnylam, Bayer, Pfizer, Fire-1. Konstantinos Koskinas has declared to have potential conflicts of interest to report: honoraria from MSD, Daiichi Sankyo, Sanofi. Felix Mahfoud has declared to have potential conflicts of interest to report: research grants from Deutsche Forschungsgemeinschaft (SFB TRR219), Deutsche Gesellschaft für Kardiologie (DGK), Deutsche Herzstiftung, Ablative Solutions, ReCor Medical. Consulting fees, payment honoraria lectures, presentations, speaker, support travel costs: Ablative Solutions, Astra-Zeneca, Novartis, Inari, Recor Medical, Medtronic, Philips, Merck. Borge Nordestgaard has declared to have potential conflicts of interest to report: consultancies/talks for AstraZeneca, Sanofi, Ionis, Amgen, Amarin, Novartis, Novo Nordisk, Esperion, Lilly, Arrowhead, Marea, Merck, Torrent, USV – honoraria used for research. Steffen Petersen has declared to have potential conflicts of interest to report: consultancy for Circle Cardiovascular Imaging Inc. Calgary, Alberta, Canada. Emma Svennberg has declared to have potential conflicts of interest to report: Abbott, Astra Zeneca, Bayer, Bristol-Myers, Squibb-Pfizer, Johnson & Johnson.
In this episode, we review the high-yield topic of Traumatic Aortic Disruption from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
BUFFALO, NY — December 12, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled “Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence.” The study was led by first authors Parminder Singh of the Buck Institute for Research on Aging and Ravinandan Venkatasubramanian of the University of Colorado Boulder, with senior contributions from corresponding authors Pankaj Kapahi (Buck Institute for Research on Aging) and Zachary S. Clayton (University of Colorado Boulder and University of Colorado Anschutz Medical Campus). The researchers investigated how methylglyoxal (MGO), a toxic byproduct that builds up in blood vessels with age or metabolic dysfunction like diabetes, contributes to artery stiffening. Their findings are especially important to aging and diabetes-related cardiovascular risk. Aortic stiffening, which reduces the flexibility of the body's largest artery, is a key predictor of cardiovascular disease in older adults. The research team used young and aged mice to study how MGO affects vascular health. In young mice, chronic exposure to MGO increased aortic stiffness by 21%. However, when treated with Gly-Low, a supplement containing natural compounds such as nicotinamide and alpha-lipoic acid, this stiffening was completely prevented. Gly-Low also reduced the buildup of MGO and its harmful byproducts, particularly MGH-1, in both blood and tissue. “Aortic stiffness was assessed in vivo via pulse wave velocity (PWV) and ex vivo through elastic modulus.” The research showed that MGO's damage goes beyond structural changes. It also caused the endothelial cells that line blood vessels to enter senescence, a state in which cells stop dividing and begin releasing inflammatory signals. This led to lower levels of nitric oxide, a molecule essential for blood vessel relaxation. In human vascular cells in lab culture, Gly-Low reversed these aging-like changes and restored nitric oxide production. In older mice, which naturally develop stiffer arteries, Gly-Low treatment during four months significantly reduced stiffness and lowered MGO and MGH-1 levels. This suggests that Gly-Low may help slow or even reverse vascular aging by reducing glycation stress. The study also identified the glyoxalase-1 pathway as a critical mechanism. This is a natural detox system that helps clear harmful molecules like MGO. Gly-Low appeared to boost this pathway. When the pathway was chemically blocked, Gly-Low's protective effects disappeared, confirming its role in the process. Overall, the findings highlight glycation stress as a modifiable contributor to vascular aging. The results suggest that natural compound-based therapies, like Gly-Low, may offer a potential strategy to protect arteries from age- and diabetes-related damage. DOI - https://doi.org/10.18632/aging.206335 Corresponding authors: Pankaj Kapahi - pkapahi@buckinstitute.org; Zachary S. Clayton - Zachary.Clayton@cuanschutz.edu Abstract video: https://www.youtube.com/watch?v=i_rtq8eIb8c Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Aortic Regurgitation: Beyond the Valve Guest: Vidhu Anand, M.B.B.S. Host: Kyle Klarich, M.D. In this episode of Mayo Clinic's “Interviews With the Experts,” Dr. Klarich and Dr. Anand discuss evolving approaches to assessing left ventricular remodeling in chronic aortic regurgitation. Dr. Vidhu Anand discusses research showing that LV volumes, global longitudinal strain, and myocardial fibrosis can detect dysfunction earlier than traditional guideline thresholds. Listeners can expect to better understand the role of multimodality imaging, extra valvular involvement, and practical steps echocardiographers can take to optimize AR assessment. Topics Discussed: What imaging markers help detect early myocardial dysfunction in AR, and how do they assist in risk stratification? Guidelines traditionally focus on LV dimensions and ejection fraction for surgical decision-making in AR. Is there any data that guidelines may not be capturing patients at the optimal time? Is there a role of multimodality imaging in AR? What practical steps can a sonographer or echocardiographer today to bring their AR assessment closer to what your research suggests is optimal? Please reference Dr. Anand's research article(s) here: https://pubmed.ncbi.nlm.nih.gov/39545891/ https://pubmed.ncbi.nlm.nih.gov/33253815/ https://pubmed.ncbi.nlm.nih.gov/39218370/ Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826251344842
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826251336314
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826251344848
Recorded at the BASICS Pre-Hospital Care Conference at Sketchley Grange, this episode explores one of the most experimental tools in civilian trauma care — the abdominal aortic and junctional tourniquet. Dr Ed Barnard joins us to discuss why this device was developed, how it works, and where it might — just might — save lives when all other options have failed. The conversation traces the problem of non-compressible haemorrhage, the leading cause of potentially survivable trauma death. Conventional limb tourniquets, pelvic binders and packing can't reach these deep bleeding sites. The AAJT offers a radical alternative: external aortic compression to buy a few crucial minutes until surgical control or REBOA is possible. Ed explains the mechanism — an inflatable, ratcheted belt that can occlude the aorta or major junctional vessels — and the evidence so far. Laboratory and volunteer data show that it can stop flow, but pain and tissue ischaemia make it difficult to tolerate for long. Clinical experience remains limited to small case series, mostly in military or research settings, and no human trials yet demonstrate a survival benefit. The discussion is candid about risk and realism. The AAJT is a last-resort device, to be used only within strict governance, with clear time limits and immediate plans for definitive haemorrhage control. It's not something you reach for on a normal shift — it's something you might need once in a career, and only if every other option has failed. Ed shares insights from ongoing research, including its potential role as a bridge to REBOA, and the governance frameworks that should surround any trial use. The episode ends with a look to the future: how civilian and military collaboration might refine indications, training, and data collection for this rare but potentially life-saving intervention. Surgeon Captain Ed Barnard Surgeon Captain Ed Barnard is a Consultant in Emergency Medicine at Addenbrooke's Hospital, Cambridge, and a Professor of Emergency Medicine with the Defence Medical Services. He also serves with East Anglian Air Ambulance as a HEMS doctor (having had many years as a BASICS responder). His academic work focuses on prehospital and military trauma care, with a portfolio spanning clinical trials, blood product innovation, and trauma system development. Ed's academic work focuses on improving survival from catastrophic bleeding, particularly non-compressible and junctional haemorrhage. He has published and presented widely on trauma resuscitation, traumatic cardiac arrest, and the evolving role of devices such as the abdominal aortic and junctional tourniquet (AAJT) and REBOA. He is a co-author of the 2025 BMJ Military Health systematic review examining the utility of the AAJT-S in military practice. He is also an experienced educator, contributing to trauma training for BASICS, HEMS, and Defence Medical Services, and continues to combine clinical work with research aimed at translating lessons from military to civilian trauma care. About BASICS: The British Association for Immediate Care (BASICS) is a UK charity uniting clinicians dedicated to pre-hospital emergency medicine. Founded in 1977, it supports regional immediate-care schemes, delivers national training, and hosts the annual BASICS Pre-Hospital Care Conference, bringing together experts in trauma, retrieval, and critical care — like this conversation with Dr Ed Barnard.
Host: Darryl S. Chutka, M.D. Guests: Christopher Francois, M.D. The risk of thoracic aortic dissection increases as the diameter of the aorta widens. A diameter greater than 5 cm is associated with an increased risk of dissection in the general population. Patients with Marfan Syndrome have defective connective tissue and dissection commonly occurs with diameters less than 5 cm. Other health conditions associated with aortic dilation and potential dissection include Ehlers Danlos and those with bicuspid aortic valves. It therefore becomes extremely important to accurately assess the aorta. Fortunately, we now have a variety of imaging tools available and several of these tools are relatively new. My guest for today's podcast is Dr. Christopher Francois, from the Department of Diagnostic Radiology at the Mayo Clinic and he'll bring us up to date regarding the most recent imaging techniques as we continue our series on vascular medicine. We'll discuss who's at risk for an aortic aneurysm, when some of the more traditional imaging is indicated and when we should consider some of the newer imaging tools. Mayo Clinic Talks: Vascular Medicine Series | Mayo Clinic School of Continuous Professional Development Connect with us and learn more here: https://ce.mayo.edu/online-education/content/mayo-clinic-podcasts
A silent danger lurks within the descending thoracic aorta. While most Type B aortic dissections are managed medically, up to half of these patients will either require life-saving surgery or die within just five years. So how do we separate those who will quietly recover from those on the edge of catastrophe? How do we protect the spinal cord, bowel, and limbs from the devastating consequences of malperfusion? Join the University of Michigan Department of Vascular Surgery as they tackle the high-stakes decisions behind managing this unpredictable disease—where timing is critical, interventions are evolving, and lives hang in the balance. Hosted by the University of Michigan Department of Vascular Surgery: · Robert Beaulieu, Program Director · Frank Davis, Assistant Professor of Surgery · Luciano Delbono, PGY-5 House Officer · Andrew Huang, PGY-4 House Officer · Carolyn Judge, PGY-2 House Officer Learning Objectives: 1. Discuss general approach to diagnosis and management of TBAD. 2. Identifying high-risk features in uncomplicated TBAD and understanding their role in determining the need for surgical management. 3. Review endovascular techniques for managing malperfusion of the limbs, viscera, and spinal cord and discuss associated decision making. References: Authors/Task Force Members, Czerny, M., Grabenwöger, M., Berger, T., Aboyans, V., Della Corte, A., Chen, E. P., Desai, N. D., Dumfarth, J., Elefteriades, J. A., Etz, C. D., Kim, K. M., Kreibich, M., Lescan, M., Di Marco, L., Martens, A., Mestres, C. A., Milojevic, M., Nienaber, C. A., … Hughes, G. C. (2024). EACTS/STS Guidelines for Diagnosing and Treating Acute and Chronic Syndromes of the Aortic Organ. The Annals of Thoracic Surgery, 118(1), 5–115. https://doi.org/10.1016/j.athoracsur.2024.01.021 de Kort, J. F., Hasami, N. A., Been, M., Grassi, V., Lomazzi, C., Heijmen, R. H., Hazenberg, C. E. V. B., van Herwaarden, J. A., & Trimarchi, S. (2025). Trends and Updates in the Management and Outcomes of Acute Uncomplicated Type B Aortic Dissection. Annals of Vascular Surgery, S0890-5096(25)00004-4. https://doi.org/10.1016/j.avsg.2024.12.060 Eidt, J. F., & Vasquez, J. (2023). Changing Management of Type B Aortic Dissections. Methodist DeBakey Cardiovascular Journal, 19(2), 59–69. https://doi.org/10.14797/mdcvj.1171 Lombardi, J. V., Hughes, G. C., Appoo, J. J., Bavaria, J. E., Beck, A. W., Cambria, R. P., Charlton-Ouw, K., Eslami, M. H., Kim, K. M., Leshnower, B. G., Maldonado, T., Reece, T. B., & Wang, G. J. (2020). Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections. Journal of Vascular Surgery, 71(3), 723–747. https://doi.org/10.1016/j.jvs.2019.11.013 MacGillivray, T. E., Gleason, T. G., Patel, H. J., Aldea, G. S., Bavaria, J. E., Beaver, T. M., Chen, E. P., Czerny, M., Estrera, A. L., Firestone, S., Fischbein, M. P., Hughes, G. C., Hui, D. S., Kissoon, K., Lawton, J. S., Pacini, D., Reece, T. B., Roselli, E. E., & Stulak, J. (2022). The Society of Thoracic Surgeons/American Association for Thoracic Surgery Clinical Practice Guidelines on the Management of Type B Aortic Dissection. The Annals of Thoracic Surgery, 113(4), 1073–1092. https://doi.org/10.1016/j.athoracsur.2021.11.002 Papatheodorou, N., Tsilimparis, N., Peterss, S., Khangholi, D., Konstantinou, N., Pichlmaier, M., & Stana, J. (2025). Pre-Emptive Endovascular Repair for Uncomplicated Type B Dissection—Is This an Option? Annals of Vascular Surgery, S0890-5096(25)00007-X. https://doi.org/10.1016/j.avsg.2025.01.003 Trimarchi, S., Gleason, T. G., Brinster, D. R., Bismuth, J., Bossone, E., Sundt, T. M., Montgomery, D. G., Pai, C.-W., Bissacco, D., de Beaufort, H. W. L., Bavaria, J. E., Mussa, F., Bekeredjian, R., Schermerhorn, M., Pacini, D., Myrmel, T., Ouzounian, M., Korach, A., Chen, E. P., … Patel, H. J. (2023). Editor's Choice - Trends in Management and Outcomes of Type B Aortic Dissection: A Report From the International Registry of Aortic Dissection. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery, 66(6), 775–782. https://doi.org/10.1016/j.ejvs.2023.05.015 Writing Committee Members, Isselbacher, E. M., Preventza, O., Hamilton Black Iii, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Jones, W. S., Kalahasti, V., … Woo, Y. J. (2022). 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology, 80(24), e223–e393. https://doi.org/10.1016/j.jacc.2022.08.004 Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen
A 17 yo male presents for follow up on a “fainting” episode that occurred during football practice at the end of a running exercise. He states, “I do not know what happened. We finished a set of running sprints and next thing I knew, I was on the ground.” He denies injury from the event and history of prior episodes. His physical examination reveals a crescendo-decrescendo systolic murmur heart best at the apex, increasing in intensity with position change from supine to standing position. This most likely represents: A. Mitral regurgitation B. Physiologic murmur C. Hypertrophic cardiomyopathyD. Aortic stenosis Visit fhea.com to learn more!
In today's VETgirl online veterinary continuing education podcast, we interview Dr. Missy Carpentier, DACVIM (Neurology) of Minnesota Veterinary Neurology on aortic thromboembolism (ATE) in dogs. While this seems like a "cardiology" or emergency critical care problem, ATE is a classic presentation for the "down" dog. That said, ATE in dogs is entirely different from cats—in everything from signalment and clinical presentation to prognosis. Tune in to learn all things ATE, including how we diagnose and treat this hypercoagulable disease, and what the prognosis is.
In today's VETgirl online veterinary continuing education podcast, we interview Dr. Missy Carpentier, DACVIM (Neurology) of Minnesota Veterinary Neurology on aortic thromboembolism (ATE) in dogs. While this seems like a "cardiology" or emergency critical care problem, ATE is a classic presentation for the "down" dog. That said, ATE in dogs is entirely different from cats—in everything from signalment and clinical presentation to prognosis. Tune in to learn all things ATE, including how we diagnose and treat this hypercoagulable disease, and what the prognosis is.
Drs. Rick Ferraro and Sneha Nandy discuss ‘Diagnosis of ATTR Cardiac Amyloidosis' with Dr. Venkatesh Murthy. In this episode, we explore the diagnosis of ATTR cardiac amyloidosis, a condition once considered rare but now increasingly recognized due to advances in imaging and the availability of effective therapies. Dr. Venkatesh Murthy, a leader in multimodality imaging, discusses key clinical and laboratory features that should raise suspicion for the disease. We also examine the role of nuclear imaging and genetic testing in confirming the diagnosis, as well as the importance of early detection. Tune in for expert insights on navigating this challenging diagnosis and look out for our next episode on treatment approaches for cardiac amyloidosis! Audio editing for this episode was performed by CardioNerds Intern, Julia Marques Fernandes. Enjoy this Circulation Paths to Discovery article to learn more about the CardioNerds mission and journey. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscripts here. CardioNerds Cardiac Amyloid PageCardioNerds Episode Page Pearls: - Diagnosis of Transthyretin amyloid cardiomyopathy 1. Recognizing the Red Flags – ATTR cardiac amyloidosis often presents with subtle but telling signs, such as bilateral carpal tunnel syndrome, low-voltage ECG, and a history of lumbar spinal stenosis or biceps tendon rupture. If you see these features in a patient with heart failure symptoms, think amyloidosis! 2. “Vanilla Ice Cream with a Cherry on Top” – On strain echocardiography, apical sparing is a classic pattern for cardiac amyloidosis. While helpful, it's not foolproof—multimodal imaging and clinical suspicion are key! 3. Nuclear Imaging is a Game-Changer – When suspicion for cardiac amyloidosis is high à a positive PYP scan with SPECT imaging (grade 2 or 3 myocardial uptake) in the absence of monoclonal protein (ruled out by SPEP, UPEP, and free light chains) is diagnostic for ATTR amyloidosis—no biopsy needed! 4. Wild-Type vs. Hereditary? Know the Clues – Older patients (70+) are more likely to have wild-type ATTR, while younger patients (40s-60s), especially those with neuropathy and a family history of heart failure, should raise suspicion for hereditary ATTR. Genetic testing is crucial for distinguishing between the two. Note that some ATTR variants may predispose to a false negative PYP scan! 5. Missing Amyloidosis = Missed Opportunity – With multiple disease-modifying therapies now available, early diagnosis is critical. If you suspect cardiac amyloidosis, don't delay the workup—early treatment improves outcomes! Notes - Diagnosis of Transthyretin amyloid cardiomyopathy What clinical features should raise suspicion for ATTR cardiac amyloidosis? ATTR cardiac amyloidosis is underdiagnosed because symptoms overlap with other forms of heart failure. Red flags include bilateral carpal tunnel syndrome (often years before cardiac symptoms), low-voltage ECG despite increased LV wall thickness, heart failure with preserved ejection fraction (HFpEF) with a restrictive pattern, and history of lumbar spinal stenosis, biceps tendon rupture, and/or peripheral neuropathy, including possible autonomic dysfunction (e.g., orthostatic hypotension). Remember: If an older patient presents with heart failure and unexplained symptoms like neuropathy or musculoskeletal issues, think amyloidosis! What is the differential diagnosis for a thick left ventricle (LVH) and how does ATTR amyloidosis fit into it? Hypertension: Most common cause of LVH, typically with a history of uncontrolled high blood pressure. Aortic stenosis: May present with concentric LVH. Hypertrophic cardiomyopathy (HCM): Genetic disorder typically presenting with asymmetric LVH, especially in younger patients. Infiltrative cardiomyopathy: Often due to amyloidosis, sarcoidosis,
In this episode, we review the high-yield topic Aortic Regurgitation from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
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