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The following article of the Sustainability industry is: “The New Low-Risk Economy: Investing in Natural Capital” by Kathy Gregoire, Executive Director, Pronatura Mexico.
en years ago, amid plenty of bearish sentiment, David did something unique in the history of his 5-Stock Samplers: he picked five stocks specifically to beat the market over just the next year. The common denominator? Each ranked among the lowest-risk companies in his investing universe.A decade later, Rick Munarriz joins him to fire up the time machine. Apple, Canadian National Railway, Disney, Ecolab, and Alphabet go back on the scoreboard—not merely for the one-year contest they were chosen to play, but for the nine bonus years that followed. Which delivered? Which disappointed? And what does a decade teach us about what “low risk” really means?Five companies. One unusually short original time horizon. Ten years of actual results—and another chance to ask what we got right, what we got wrong, and what we can learn for the decade ahead.Host: David GardnerGuest: Rick MunarrizProducer: Bart ShannonCompanies Mentioned: AAPL, CNI, DIS, ECL, GOOG Learn more about your ad choices. Visit megaphone.fm/adchoices
Infection control consultant Katherine West explains why current Bundibugyo Ebola activity in the Democratic Republic of Congo and Uganda is considered low risk for the United States. She reviews outbreak drivers—border-spanning transmission, insurgent attacks on treatment centers, community distrust, and limited PPE—and summarizes Uganda's rapid public-health response (isolation, contact tracing, lab testing) that ended local transmission. West covers clinical features (flu-like “dry” phase, then gastrointestinal “wet” phase; bleeding in about 10%), transmission dynamics, and the role of bats. She recounts U.S. Ebola experience and outlines preparedness measures: airport screening at major hubs, designated treatment centers and transport teams, available PPE and disinfectants, and EMS-specific guidance (droplet/contact precautions, avoid aerosol-generating procedures, mask the patient, use closed suction).
What if you could beat a higher offer without paying more? Justin Butlion knows how. He’s completed five micro SaaS acquisitions, built a 10-app portfolio, and spends roughly three hours a week managing it. His biggest deal? $98,000 with 50% seller financing. And that’s where this gets interesting. Justin isn’t trying to outbid everyone. He’s learning how to become the buyer sellers want to choose. Move fast. Understand the seller. Know the industry. Structure the deal so it works for both sides. And seller financing? Justin calls it a powerful weapon. He reveals how he negotiated deals with financing at under 2% interest, why developers often make surprisingly motivated sellers, and how the right terms can let you acquire more without putting all your cash on the line. But the real edge starts before you make an offer. Justin breaks down exactly what he looks for in a micro SaaS: B2B customers, sticky recurring revenue, low churn, simple tech, built-in distribution, and minimal operational risk. He also walks through how he analyzes the SaaS funnel to spot opportunities that the headline numbers might completely miss. Then there’s the part most acquisition conversations skip. What happens after you buy? Justin gets brutally honest about cash flow getting squeezed by seller payments, the hidden cost of managing multiple small businesses, his costly lessons with U.S. business structures, and why bigger acquisitions may ultimately make more sense. Because the goal isn't to own the most businesses. It’s to build the most valuable portfolio without giving up your life in the process. If you’re buying micro SaaS, negotiating acquisitions, or looking for ways to win deals without simply offering the highest price, this conversation is packed with strategies you can actually use.
Ask a question hereNatalie Hood continues her conversation with Dewey Case of the Council for the Model Aquatic Health Code, separating cold-plunge science from wellness-industry hype.Cold plunges may be popular, but cold water changes chemical reaction rates, sanitizer performance, testing accuracy, and the body's physiological response. Being young, athletic, or highly experienced around water does not make anyone immune to blood-sugar crashes, loss of consciousness, drowning, or other emergencies.Natalie and Dewey discuss why cold-water samples should be allowed to warm before testing, why commercial plunges should strongly consider supplemental treatment such as UV, ozone, or advanced oxidation, and why a quick pre-entry rinse can remove a surprising amount of contamination before it enters a very small body of water.They also address the biggest myth of all: because someone only spends a few minutes in a cold plunge, the risk must be low. The exposure may be short, but the risks are not necessarily smaller—they are simply different.Topics discussed include:Why even healthy, conditioned athletes can experience emergenciesThe dangers of using a cold plunge, pool, or spa aloneHow cold temperatures affect water-testing reactionsWhy cold samples should be capped and warmed before testingReduced sanitizer reaction rates in cold waterWhy small water volume and heavy bather loads create greater riskThe value of UV, ozone, and advanced oxidationSweat, ammonia, urea, dirt, and everything else bathers drag into the waterWhy pre-entry showers matterHow a simple rinse can substantially reduce contaminantsWhy short exposure does not automatically mean low riskThe importance of supervision, maintenance, testing, and operator diligenceThe takeaway is simple: be diligent. Know what the water is doing, test it regularly, maintain the vessel properly, and never assume that experience or physical fitness makes someone bulletproof.Download the Cold Water Venue Guidance from the Council for the Model Aquatic Health Code.Natalie also shares an update on her Tennessee Triple Crown Open Water Swim Challenge. She will swim more than 21 miles across three open-water marathon events to benefit Every Child a Swimmer through her fundraiser, She Swims So They Can.Special thanks to campaign sponsors Revved Up Apparel, H2Flow Controls, Tenjam, and Talking Pools Podcast. Support the showThank you so much for listening! You can find us on social media:FacebookInstagramTik TokEmail us: talkingpools@gmail.com
Commentary by Dr. Jae-Sik Jang.
Willard and Grandi discuss how the majority of the Giants' moves have been rather low-risk, especially with Arraez and Ray, who were expected to be dealt.
An independent alcohol researcher says he's concerned officials have slowed a review into the country's drinking advice.
Most investors focus on chasing returns.Chris Belchamber believes they're asking the wrong question.With more than 40 years in global finance, including leadership at JPMorgan Chase and as founder of CB Investment Management, Chris explains why protecting your money is the first step toward growing it. He shares why compounding matters more than short-term gains, how emotional investing destroys long-term wealth, and why business owners should treat investing differently from running their companies.If you've ever wondered whether you're taking unnecessary investment risk or simply reacting to headlines, this conversation offers a practical framework for making smarter financial decisions.In this episode, you'll learn:• Why protecting wealth should always come before growing it• The hidden math behind compounding that many investors overlook• How large investment losses can permanently damage long-term returns• Why successful investing requires a system instead of emotions• How business owners can separate operating cash from investment capital• The importance of minimizing drawdowns during volatile markets• Why informed investors make better financial decisionsAbout Chris BelchamberChris Belchamber is an investment strategist, wealth manager, author, and founder of CB Investment Management. A mathematics graduate from the University of Oxford, he spent more than four decades in global finance, including serving as Managing Director of Proprietary Trading at JPMorgan Chase. He is the author of Invest Like The Best and helps investors build wealth through disciplined, risk-conscious investment strategies.Connect with ChrisWebsite: https://chris-belchamber.com/CB Investment Management: https://www.cbinvestmentmanagement.comLinkedIn: https://www.linkedin.com/in/chrisbelchamberHere is the link to Amazon:https://geni.us/InvestLiketheBesthttps://calendly.com/chriscbim/meeting301-335-8587Connect with Gary Heldt
How much alcohol is too much, when it comes to health risks like cancer and is Aotearoa's official guide to low risk drinking dangerously out of date? The Health NZ guidelines are being reviewed as part of a three-year cancer action plan, released last week. The cancer society said alcohol is a risk factor in a least seven cancers and is the cause of about five percent of all cancers. Alcohol researcher and Massey University Associate Professor Andy Towers spoke to Lisa Owen.
Myelodysplastic syndromes (MDS), a rare category of bone marrow disorders that may develop into acute myeloid leukemia, are categorized into risk groups ranging from very low to very high risk. However, this language can be misleading to patients. Low risk (LR) does not equate to low impact or lack of urgency. In this episode, CANCER BUZZ speaks with Amy DeZern, MD, MHS, from Sidney Kimmel Comprehensive Cancer Center, and Christin Blair DeStefano, MD, FACP, from Walter Reed National Military Medical Center, about the importance of aligning language and terminology regarding LR-MDS across academic and community settings. These experts candidly discuss their own collaboration and the importance of early conversations with patients to align expectations on goals, disease trajectory, and treatment sequencing. Guests: Amy DeZern, MD, MHS Hematologist/Oncologist Director, Bone Marrow Failure and MDS Program Sidney Kimmel Comprehensive Cancer Center Baltimore, MD Christin Blair DeStefano, MD, FACP Hematologist/Oncologist Walter Reed National Military Medical Center Bethesda, MD "I really try and individualize [language] to a patient and their family, because I worry that sometimes the terminology 'lower risk' may not correctly convey the impact the disease is going to have on an individual human's life." — Amy DeZern, MD, MHS "Frequent reassessment—questioning our patients about quality of life and if we're meeting the goals they have—should be something that's readily reassessed, especially in the lower risk space, every 2 to 3 months, just to make sure we don't put anybody on autopilot." — Amy De Zern, MD, MHS "There's been such an explosion in understanding the molecular landscape of MDS and slicing and dicing it into different diseases that fall under the MDS umbrella. It has sometimes created a little bit of confusion." — Christin Blair DeStefano, MD, FACP Resources: ACCC Hematologic Malignancies Resources Blood Cancer Awareness Month: Tackling Communication Challenges Addressing Frequency of Care to Improve Quality of Life in Patients with Low-Risk MDS Defining and Managing Erythropoietin Stimulating Agents (ESAs) Failure in Patients with Low-Risk MDS
This week, we break down another wild mix of headlines in entertainment, politics, sports, and internet culture. We get into Ray J going viral after opening up on Adrien Broner's livestream, the latest on the U.S. and Iran trying to come to terms on a broader peace deal after a temporary halt in fighting, and the Texas couple behind the “Blessings in No Time” pyramid scheme getting sentenced to 40 years each in federal prison. We also discuss the tragic police shooting at a Mississippi Walmart that left 1-year-old Kohen Wiley dead, recap of UFC event on the White House South Lawn , the New York Knicks winning their first NBA title since 1973 and what their future looks like, and Ice Cube's BIG3 taking steps toward the public markets. All that and more on this week's episode. for more,
Irish guidelines on what constitutes low-risk alcohol consumption may need to be reconsidered based on latest research, according to a new report from the Health Information and Quality Authority (HIQA).HIQA's Deputy Director of Health Technology Assessment, Michelle O'Neill and Frank Murray Chair of The Alcohol Health Alliance Ireland and Liver specialist, joined Shane and Ciara to discuss the report and its findings' implications.
This episode reframed “AI in law” as a business-operations opportunity, focusing on low-risk, high-return use cases across the back office (finance, operations, IT, HR, and knowledge). Bill Brice and April Heimerl emphasized starting with real process pain points, then using AI to reduce repetitive work (e.g., time-entry cleanup, month-end support, intake triage, policy/FAQ summarization) while keeping human oversight and clear guardrails. The discussion closed with practical steps firms can take immediately: pick one workflow, pilot with users, and measure time saved and friction removed. Moderator: @April Heimerl - April Heimerl, Manager, Epiq Advisory for Law Firms Speaker: @Bill Bice - CEO, Zebraworks Recorded on 06-16-2026.
Dr. Alexander Garza, the Chief Community Health Officer at SSM Health, joins Megan Lynch ahead of the World Cup. How concerned should we be about Ebola and World Cup visitors? (Photo by Jay Biggerstaff/Getty Images)
Commentary by Dr. Jian'an Wang.
LBCT: Real-World Reintervention Rate Among TAVR Low-Risk Medicare Patients
LBCT: Six-year Outcomes of Patients with Aortic Stenosis in The Evolut Low Risk Trial
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Jim Beach is an entrepreneurship educator, author, and radio host. He hosts School for Startups Radio and teaches founders how to build practical, profitable businesses without hype, shortcuts, or unnecessary risk. Key Discussion Themes Getting fired—and using it as a starting line instead of a dead end Why Jim teaches entrepreneurship without creativity, big risk, or “passion-first” thinking The case for copying proven business models (ethically) instead of chasing “original ideas” How businesses serve by solving real problems—sometimes in unexpected ways Time management, support systems, and building a sustainable work-life balance Why “execution beats excuses” and how to keep moving when you're the roadblock Listener Takeaway If you've been waiting to feel ready, find your “one perfect idea,” or discover your passion first—stop waiting. Pick something proven, start small, and execute. Momentum beats motivation. Guest Website Links www.SchoolForStartupsRadio.comwww.RealEnvironmentalist.comwww.JimBeach.com Guest Social Links LinkedIn: https://www.linkedin.com/in/jamesabeach/ X: https://x.com/entrepreneurjim Instagram: https://www.instagram.com/entrepreneurjim/ Facebook: https://www.facebook.com/theschoolforstartups CTA Listen to the full episode here: https://entrepreneurconundrum.com/jimbeach Jim Beach Linkedin - https://www.linkedin.com/in/jamesabeach/ X.com - https://x.com/entrepreneurjim Instagram - https://www.instagram.com/entrepreneurjim/ Facebook - https://www.facebook.com/theschoolforstartups You can learn more about my work at: www.SchoolForStartupsRadio.com www.RealEnvironmentalist.com www.JimBeach.com Virginia Purnell Funnel & Visibility Specialist Distinct Digital Marketing (833) 762-5336 virginia@distinctdigitalmarketing.com www.distinctdigitalmarketing.com
This hour, Scoot talks to Susan Hassig, Associate Professor in the Tulane School of Public Health and Tropical Medicine, to give insight about the hantavirus.
Discover how modern advertising functions as your business's ultimate "crystal ball." This episode reveals the power of leveraging paid ads to gain instant, invaluable data on your audience, offers, and campaign effectiveness. Learn why advertising is an investment that either multiplies capital or provides crucial insights, effectively eliminating the concept of "failure" and opening up unparalleled, low-cost opportunities for rapid business growth. Key Takeaways Advertising IS Your Crystal Ball: Paid ads provide immediate, precise data on your perfect audience, ad effectiveness, and offer performance, just like a predictive tool. Data Drives Decisions: Every ad campaign, successful or not, generates vital data. This data is the true value, guiding optimizations and informing future strategies. No More "Failure": With instant feedback and quick data analysis, advertising allows rapid adjustments. "Failed" ads are simply data-gathering exercises, not costly mistakes. Investment, Not Expense: When executed properly, advertising acts as capital that multiplies returns or provides strategic insights, transforming it from a cost center into a growth engine. Affordable & Powerful: Modern advertising offers unprecedented opportunities for growth at an incredibly low cost, enabling rapid testing, optimization, and scaling for any business. Timestamps [00:00] The "Crystal Ball" Analogy [00:18] Frank Kern's Introduction [00:32] The Hypothetical Crystal Ball Explained [01:04] The Value of Insights [01:17] Advertising: The Real Crystal Ball Revealed [01:37] Why Data is Your Most Valuable Asset [02:06] Advertising as Capital, Not an Expense [02:20] Your Personal Marketing Department [02:35] The Myth of Advertising Failure [02:46] Low Risk, Instant Results for Growth [03:02] Unprecedented Opportunity in Modern Ads
4.29.26, Kevin Sheehan opens up the show recapping the Tuesday night NBA Playoff games and discussing how the Commanders should take a swing on Brandon Aiyuk with a low risk deal.
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In this episode of the Breakfast Leadership Show, Michael sits down with Vlad to unpack a long, disciplined path to financial freedom built on consistency, risk management, and mindset rather than hype or shortcuts. Vlad shares his journey from immigrating to the United States from Ukraine in 1989 to rising into a senior role at a Fortune 500 company. While professionally successful, the cost was significant stress and declining health. Over the years, Vlad explored multiple entrepreneurial paths including trading systems, bots, real estate, and even operating a sandwich shop. None delivered sustainable freedom on their own. What ultimately worked was a 15-year process of building a repeatable income system alongside his full-time job. Vlad explains how this approach created optionality rather than pressure, allowing him to achieve financial independence without needing to immediately exit corporate life. Michael highlights the leadership discipline required to play a long game rather than chase fast wins. The conversation dives into Vlad's low-risk trading philosophy, centered on selling strategies designed for predictability rather than market timing. With clearly defined downside protection and a focus on compounding, Vlad explains why consistency matters more than aggressive returns. Michael reinforces this perspective by referencing long-term investing principles often associated with Warren Buffett, emphasizing patience, clarity, and emotional control. They also explore the psychology of trading and leadership, including the dangers of impulsive decisions, the importance of due diligence, and why any income strategy must align with an individual's work ethic and lifestyle. As AI-driven disruption increases job insecurity, Michael frames alternative income streams as a leadership responsibility rather than a side hustle. The episode closes with a discussion on economic diversification and personal resilience. Vlad extends a special offer to Breakfast Leadership Network listeners, providing free access to his community and strategy program, along with mentorship support to help professionals build sustainable income systems without excessive risk. https://www.instagram.com/vladswingtrader https://www.youtube.com/@vladswingtrader%E2%81%A9
In this episode of the LiverHealthPOD John, Will and Paul discuss "Lean MAFLD". These patients may not fit the typical metabolic stereotype, but they can still progress to fibrosis and cirrhosis. which challenges the outdated assumption that fatty liver disease is simply a consequence of obesity. People with a “normal” BMI can still develop significant hepatic steatosis and inflammation, often driven by a combination of genetic susceptibility, visceral adiposity, insulin resistance, and environmental factors.Find out more in this episode.Don't forget to leave us a 5 star rating and send us a message of questions to LiverHealthPod@gmail.com
Keith McLachlan and Simon Brown explore this funding source for mining companies, comparing the situations of Franco-Nevada and Barrick Mining.
Tired of coming home exhausted only to spend hours charting after the kids are in bed? You're not alone. In this episode of Bootstrap MD, host Dr. Mike Woo-Ming opens up about the pajama time reality that plagues so many physicians, those late-night documentation sessions that steal evenings, family time, and peace of mind. He shares how, despite promises from EHRs and dictation tools over the years, the administrative burden has only shifted, not disappeared until ambient AI scribes changed the game for him. Dr. Woo-Ming explains exactly what ambient AI scribes are: tools that passively listen to natural patient conversations (not rigid dictation), understand clinical context, and generate structured SOAP notes, progress notes, or whatever your workflow needs often in seconds. Unlike old-school transcription, ambient AI captures messy, real-world encounters while you're fully present with the patient, making eye contact and listening without typing. He breaks down the real ROI in three layers: Time: Studies show 50-75% reductions in documentation time, often saving over 2 hours daily and slashing after-hours "pajama time" by 70-78% in some evaluations translating to hundreds of reclaimed hours per year for sleep, family, exercise, or building your side venture. Revenue: More complete, accurate notes capture complexity better, leading to improved (not upcoded) coding and potential gains like $1,300–$3,200 net per provider per month after costs, or modest RVU increases (e.g., 5.8% in recent research) that add thousands annually. Human factor: Burnout drops significantly. Some studies show reductions from ~52% to ~39% in just 30-90 days, restoring joy and presence in medicine. Dr. Woo-Ming covers practical starting points, popular standalone options, key risks, and a straightforward 5-step implementation plan to pilot without chaos. This isn't hype, it's a tool already transforming practices in 2026. By prioritizing presence over paperwork, physicians can reclaim evenings, reduce burnout, and even free up energy for entrepreneurship. Stop typing your life away—try ambient AI and see the difference. Three Actionable Takeaways: Check Your EMR First for Built-In Ambient AI: Contact your EHR support (Epic, Athenahealth, etc.) today ask if ambient AI scribe or note-generation is available and how to enable it. Many systems now include it at no extra cost or as a simple toggle. If it's there, activate and test on a few visits before exploring standalone tools this saves setup time and leverages existing HIPAA compliance. Run a Low-Risk 30-Day Personal Pilot: Pick one tool (start with your EMR's if available, or trial Abridge, Suki, DeepScribe most offer free trials). Use it for 10-20 patient encounters: record consent verbally ("I'm using an AI assistant for documentation is that okay?"), generate the note, spend extra 5-10 minutes reviewing/editing in week one. Track your after-hours charting time before and after aim to cut pajama time by at least 50% and note any burnout or presence improvements. Build Safe Consent & Review Habits from Day One: Create a simple script and one-line chart note: "Patient informed of AI documentation assistance and gave verbal consent." Always treat AI output like a draft from a trainee review every section for accuracy, omissions, or hallucinations. In month one, budget review time intentionally; it drops as the tool learns your style. Monitor coding use suggestions as a guide but apply your judgment to ensure medical necessity and avoid audit risks. About the Show: Bootstrap MD is the ultimate podcast for physician entrepreneurs looking to escape traditional healthcare and control their financial futures. Hosted by Dr. Mike Woo-Ming, a successful physician, entrepreneur, and investor, the show delivers actionable insights on starting businesses, creating passive income, and navigating healthcare entrepreneurship. Featuring interviews with industry leaders, physicians, and experts in telemedicine and digital health, it's your guide to building a profitable, fulfilling career. Tune in weekly at http://bootstrapmd.com About the Host: Dr. Mike Woo-Ming has over 20 years of experience as a physician entrepreneur. He's built and sold multiple seven-figure companies and now leads Executive Medical, a group of clinics specializing in age management and aesthetics. Through BootstrapMD, he mentors physicians in business, content creation, and autonomy. Let's Connect: www.https://www.bootstrapmd.com Want to start a podcast? Check out the Doctor Podcast Network!
LBCT: Real-World Reintervention Rate Among TAVR Low-Risk Medicare Patients
Shukri Wrights is present this evening to analyze the Eagles' offseason strategy of acquiring low-cost free agents with significant upside. He expresses enthusiasm for the addition of Marquis Brown to the wide receiver corps, highlighting that Brown introduces a much-needed speed element that the team has lacked for several years. Additionally, Shukri discusses the signings of Riq Woolen and Arnold Ebiketie, emphasizing their potential impact on the team's performance.Turning to the Flyers, Shukri acknowledges the lengthy rebuilding process the team has undergone, noting some signs of promise. However, he believes the roster still falls short in terms of talent, expressing disagreement with President of Hockey Operations Keith Jones' comments made on our Morning show regarding the team's current state.In the realm of baseball, Shukri points out that Bryce Harper is not meeting expectations during the World Baseball Classic. He examines Harper's statistics, underscoring the importance of this season for both the player and the Phillies as they seek to improve their standing.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
2. The debate continues with a comparison of Emperor Trump to Nero and Claudius, questioning if his current crisis is a result of bad luck or hubris. While Claudius favored low-risk, calculated campaigns, Trump's offensive is characterized as a "rash and incalculably risky gambit" that mirrors strategic failures in Ukraine. This conflict has solidified the Russia-Chinabond and left Israel "naked and exposed" due to US failures. Germanicus argues that the US ignored the "weak points" of its own coalition, turning Gulf State bases into liabilities rather than security assets. Likening Trump's overconfidence to Hitler's before the invasion of Russia, the speakers suggest that the US has "got suckered" into a war it cannot win through air power alone. They conclude that the only rational path is to accept defeat and reorganize, as the Romans did when facing superior Persian cavalry. (2)1680 CONSTANTINOPLE
MedboardSponsor: Medboard: https://www.medboard.com/EuropePharmacist are distributors - French guide issued to educate them: https://medboard-public-assets.s3.amazonaws.com/Regulatory/9b892d08-611c-4326-a40e-750e0364df27.pdfTeam NBTeam NB position Paper - Reduced Scrutiny, Cost saving: https://www.team-nb.org/wp-content/uploads/2026/03/Team-NB-PositionPaper-MDR-IVDR-revision-impact-on-the-sector-20260302.pdfTeam-NB Demonstrate Safety and performance - For Combination of reagent and other equipment: https://www.team-nb.org/wp-content/uploads/2026/02/Team-NB-PositionPaper-Demonstration-of-Safety-and-Performance-for-Combinatorial-Use-of-Devices-or-Equipment-V1-20260216.pdfTeam-NB- Letter on Cybersecurity - New Proposal again: https://www.team-nb.org/wp-content/uploads/2026/02/Team-NB-Letter-on-cybersecurity-20260205.pdfTeam-NB - MDR Clinical & Tech File Training - Check the dates: https://medboard-public-assets.s3.amazonaws.com/Regulatory/442102-Leaflet-MDR-Clinical-Manufacturers-Training-20260528.pdf and https://www.team-nb.org/wp-content/uploads/2026/02/Leaflet-MDR-TD-Manufacturers-Training-20260429.pdfUKConsultation on recognizing CE mark - Should it be indefinitely: https://www.gov.uk/government/consultations/medical-devices-regulations-targeted-consultation-on-the-indefinite-recognition-of-ce-marked-devicesConsultation until: April 10, 2026 UK Reliance is ongoing - Draft proposal to recognize MDSAP and other: https://www.gov.uk/government/publications/implementation-of-the-future-regulation-of-medical-devices/statement-of-policy-intent-international-recognition-of-medical-devicesBookmark the MHRA contact page -*Whispering* If you want to Whistleblow, there is a contact Chuuut!!!: https://www.gov.uk/guidance/contact-mhraSolutionsEasyIFU: For eifu and Label - Test it for Free: https://easyifu.comSmarteye: for eQMS . Ask for a Demo: https://eqms-smarteye.com/RoWIMDRFReliance Playbook - With examples to apply: https://www.imdrf.org/sites/default/files/2026-02/IMDRF%20GRRP%20WG%20N89%20Reliance%20Playbook.pdfUSAFDA Cybersecurity documentation - Final Guidance: https://www.fda.gov/media/119933/downloadMalaysiaLaunch of the Innovative Pathway - Accelerate the development of your device: https://portal.mda.gov.my/index.php/announcement/1771-implementation-of-the-innovative-medical-device-review-pathway-by-medical-device-authority-ministry-of-health-malaysiaArgentinaSelf Declaration expended for Low-Risk devices - Themis platform to be used: https://www.argentina.gob.ar/noticias/entra-en-vigencia-el-nuevo-regimen-simplificado-para-la-habilitacion-de-establecimientos PodcastEpisode 376 - Defect Management in SaMD with Anindya Mookerjea: https://podcast.easymedicaldevice.com/376-2/Episode 377 - IEC 60601 4th edition with Leo Eisner: https://podcast.easymedicaldevice.com/377-2/Episode 378 - IMDRF & Regulatory Reliance with Stephanie Grassmann: https://podcast.easymedicaldevice.com/378-2/Social Media to followMonir El Azzouzi Linkedin: https://linkedin.com/in/melazzouziTwitter: https://twitter.com/elazzouzimPinterest: https://www.pinterest.com/easymedicaldeviceInstagram: https://www.instagram.com/easymedicaldeviceThis podcast is powered by Podcastics, the easiest platform to create and publish your podcast.
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. John Forrest, a cardiologist and Director of both Interventional Cardiology and the Structural Heart Disease Program at Yale Medicine, New Haven, CT, USA, about a paper he authored titled “Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis,” published by the Journal of the American College of Cardiology. Chapters 00:00 Intro 02:38 TAVR vs SAVR Context 03:54 CDC WONDER Data, TAVR SAVR 05:37 JANS 1, TAVR vs SAVR 5-Year Outcomes 07:31 JANS 2, Temporary MCS Devices Landscape 09:17 JANS 3, Pulm Resection Post-CABG 10:23 JANS 4, PRE-HIIT Randomized Trial 12:36 Career Center 13:10 Video 1, Redo MVR After VIV TAVR 15:37 Video 2, Repair After Acute Intramural Hematoma 18:01 Video 3, Acute Severe MR Repair 19:36 Dr. Forrest, 6-Year TAVR vs SAVR 44:49 Upcoming Events 45:33 The Lifeline Podcast They explored other randomized trials involving high-risk and intermediate-risk patients with aortic stenosis and examined the specific goals of this low-risk trial. The discussion then delved into the trial's results, highlighting that there was no significant difference in the composite endpoint of all-cause mortality or disabling stroke. However, a noteworthy finding was that the transcatheter aortic valve replacement (TAVR) arm experienced a higher reintervention rate compared to surgery, primarily due to an increased incidence of aortic regurgitation. They also addressed factors such as valve dilation, stents, and various reasons for surgical valve failure. Additionally, they examined the similarities between this trial and other partner trials and the future for low-risk patients with aortic stenosis. Joel also highlights recent JANS articles on the updated five-year outcomes of transcatheter versus surgical aortic valve replacement in patients with severe aortic stenosis at low- to intermediate-surgical risk, a United States nationwide analysis on the changing landscape of temporary mechanical circulatory support devices in the new heart allocation system, pulmonary resection post-coronary artery bypass grafting, and a randomized controlled trial on the preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or esophagus (PRE-HIIT). In addition, Joel explores redo mitral valve replacement after previous valve-in-valve mitral TAVR, aortic repair after acute intramural hematoma, and repair of acute severe mitral regurgitation due to iatrogenic papillary muscle rupture. Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned 1.) Updated 5-Year Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis at Low- to Intermediate-Surgical Risk 2.) The Changing Landscape of Temporary Mechanical Circulatory Support Devices in the New Heart Allocation System—A United States Nationwide Analysis 3.) Pulmonary Resection Post-Coronary Artery Bypass Grafting: Feasible, but Right-Sided Procedures Demand Caution 4.) Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Esophagus (PRE-HIIT): A Randomized Controlled Trial CTSNet Content Mentioned 1.) Redo Mitral Valve Replacement After Previous Valve-in-Valve Mitral TAVR 2.) Aortic Repair After Acute Intramural Hematoma 3.) Repair of Acute Severe Mitral Regurgitation Due to Iatrogenic Papillary Muscle Rupture Other Items Mentioned 1.) Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis 2.) The Lifeline: End-Tidal Carbon Dioxide Monitoring in Cardiac Surgical Emergencies 3.) Instructional Video Competition 4.) Career Center 5.) CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Wealth manager and author Geoff Saab (Low Risk Rules) makes the case for simpler, lower-cost, fully liquid investing, especially for entrepreneurs who are used to taking risks in business. They talk about the hidden cost of fees, why illiquidity can be dangerous, and why even pros cannot consistently predict market outcomes, making a disciplined long-term approach more reliable. Find out more on Substack and connect on X.
A former Australian Federal Police Detective Sergeant says the arrest of kingpin Kazem 'Kaz' Hamad has led to the reignition of the tobacco war.See omnystudio.com/listener for privacy information.
This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Drs. Mateo Marin-Cuartas, CTSNet JANS Editor and cardiac surgeon at the University Department of Cardiac Surgery at Leipzig Heart Centre University Hospital in Leipzig, SN, Germany; and Samuel Heuts, a cardiothoracic surgeon in the Department of Cardiothoracic Surgery at Maastricht University Medical Center in Maastricht, LI, about a paper they authored titled “Updated 5-Year Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis at Low- to Intermediate-Surgical Risk,” published in Heart, a journal produced by the British Medical Journal. Chapters 00:00 Intro 01:51 JANS 1, 6-Year Outcomes TAVR vs SAVR 06:45 JANS 2, Evolut THV Postdilation 09:22 Video 2, TAVI in SAVR Explantation 11:10 JANS 3, High Risk Increasing Adoption of DCD 13:17 JANS 4, Lobar Quantitation for Assessment 15:16 Video 1, Narayana Robotic AVR 17:23 Video 3, Extended Resections Podcast 18:30 Dr. Marin-Cuartas & Heuts, TAVR vs SAVR 36:42 Upcoming Events 37:32 Instructional Video Competition 38:55 Career Center They discussed the motivations behind the creation of this paper and provided insights into its Bayesian hierarchical design. Key findings included the five-year all-cause mortality rates and the risk of stroke associated with the procedures. They also referenced other studies with similar findings, such as a recently published paper from the Journal of the American College of Cardiology on the “Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis.” Finally, they explored the future of transcatheter aortic valve implantation and surgical aortic valve replacement. Joel also highlights recent JANS articles on the six-year outcomes after transcatheter vs surgical aortic valve replacement in low-risk patients with aortic stenosis, postdilation of Evolut transcatheter heart valves, insights into current practices in the United States regarding increasing adoption of donation after circulatory death in high-risk heart transplant recipients, and the value of V/Q SPECT/CT lobar quantitation for pre-treatment assessment of lung malignancy. In addition, Joel explores robotic-assisted aortic valve replacement, TAVI in SAVR explantation, and an episode of The Atrium podcast featuring host Dr. Alice Copperwheat speaking with Dr. Maninder Kalkat about extended resections. Before closing, Joel highlights upcoming events in CT surgery. JANS Items Mentioned 1.) Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis 2.) Postdilation of Evolut Transcatheter Heart Valves: Insights From Bench Testing 3.) Increasing Adoption of Donation After Circulatory Death in High Risk Heart Transplant Recipients: Insights Into Current Practices in the United States 4.) The Value of V/Q SPECT/CT Lobar Quantitation for Pre-Treatment Assessment of Lung Malignancy CTSNet Content Mentioned 1.) Robotic-Assisted Aortic Valve Replacement 2.) TAVI in SAVR Explantation: A Two-Step Technique for Successful Removal 3.) The Atrium: Extended Resections Other Items Mentioned 1.) Updated 5-Year Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis at Low- to Intermediate-Surgical Risk 2.) The Lifeline 3.) Instructional Video Competition 4.) Career Center 5.) CTSNet Events Calendar Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.
Great Pacific Gold reported 59 meters of 2.5 grams gold equivalent from near surface at Kavasuki, confirming continuity within its 15-kilometer Wild Dog trend in Papua New Guinea. With a second rig now drilling the high-risk, high-reward Kasie Ridge target, management outlined a balanced strategy between steady resource growth and potential discovery upside. Ian Wagner talks with CEO Greg McCunn and VP of Exploration, Callum Spink.
Hour 4 - Debates at Pick 9 + A very low risk full 2956 Mon, 02 Mar 2026 19:39:04 +0000 guIbhj3n4P8m8Zx243OALsFwjlElVuZP nfl,nfl draft,kansas city chiefs,society & culture Cody & Gold nfl,nfl draft,kansas city chiefs,society & culture Hour 4 - Debates at Pick 9 + A very low risk Hosts Cody Tapp & Alex Gold team up for 610 Sports Radio's newest mid-day show "Cody & Gold." Two born & raised Kansas Citians, Cody & Gold have been through all the highs and lows as a KC sports fan and they know the passion Kansas City has for their sports teams."Cody & Gold" will be a show focused on smart, sports conversation with the best voices from KC and around the country. It will also feature our listeners with your calls, texts & tweets as we want you to be a part of the show, not just a listener. Cody & Gold, weekdays 10a-2p on 610 Sports Radio. 2024 © 2021 Audacy, Inc. Society & Culture False https://player.amperwavepodcasting.com?feed-link
With Ruben Dalfovo, Saxo Equity Market strategist, today we delve into how to approach and rate the prospects for beaten down software-as-a-service (SaaS) stocks with a systematic approach and how some names may have been unfairly punished recently while the business models of others are indeed in doubt. We also look at a number of important software names reporting this week, as well as previewing the biggest hardware name of them all: Nvidia, who reports earnings Wednesday. Also, Trump tariffs, macro and FX and more on today's pod, which is hosted by Saxo Global Head of Macro Strategy John J. Hardy. Today's links: Ruben's piece: The AI stress-test for software stocks: a simple framework to spot disruption risk The JPY carry trade is important to understand, as well as the risks should it be set to unwind in coming weeks and months. Two or three times per week, you will also find links discussed on the podcast and a chart-of-the-day over at the John J. Hardy substack. Read daily in-depth market updates from the Saxo Market Call and the Saxo Strategy Team here. Please reach out to us at marketcall@saxobank.com for feedback and questions. Click here to open an account with Saxo. Intro music by AShamaluevMusic DISCLAIMER This content is marketing material. Trading financial instruments carries risks. Always ensure that you understand these risks before trading. This material does not contain investment advice or an encouragement to invest in a particular manner. Historic performance is not a guarantee of future results. The instrument(s) referenced in this content may be issued by a partner, from whom Saxo Bank A/S receives promotional fees, payment or retrocessions. While Saxo may receive compensation from these partnerships, all content is created with the aim of providing clients with valuable information and options.
In this episode of One in Ten, host Teresa Huizar welcomes Dr. Brian Allen, professor in the Department of Pediatrics at Penn State, to discuss what motivates problematic sexual behavior (PSB) in children and youth and what the research shows. Allen explains his path into the field and why he conducted a meta-analysis—combining results across studies to create a much larger dataset (about 9,000 children) and examine the strength of associations across age, gender, and different risk factors.Time Stamps Time Topic 00:00 What Drives Problematic Sexual Behavior (PSB) in Kids? (Episode Intro) 01:15 Meet Dr. Brian Allen + How He Got Into PSB Research 02:54 Meta-Analysis 101: What It Is and Why It Matters for PSB 05:26 Beyond the Assumption: Is PSB Always Linked to Sexual Abuse? 07:24 Who's Affected? Gender & Age Patterns in the Data 08:41 Age Matters: Developmental Motivations, Curiosity & Online Exposure 14:01 Why Parents Struggle to Talk About Sex, Boundaries & Prevention 16:44 What the Meta-Analysis Found: PSB's Link to Sexual Abuse (and How to Ask) 19:00 Physical Abuse, Dysregulation & Coercion: A Surprising Strong Correlate 25:35 Screening & Mental Health: Externalizing vs Internalizing Problems 29:01 Big Research Gaps: Cross-Cultural Data, Developmental Pathways & Social Media 32:12 What's Next: New Assessment Tool, Longitudinal Studies & Treatment Trials 33:38 Key Takeaways for Clinicians: Treatable, Low Risk, Don't Go Punitive 36:22 Reframing These Kids + Resources, Training, and Closing 39:10 Final Thanks & Where to Learn More ResourcesProblematic Sexual Behavior Among Children: A Meta-Analysis of Demographic and Clinical Correlates | Research on Child and Adolescent Psychopathology | Springer Nature LinkSupport the showDid you like this episode? Please leave us a review on Apple Podcasts.
Mike Johnson, Beau Morgan, and Ali Mac react to the Atlanta Hawks trading veteran center Kristaps Porzingis for Golden State Warriors forward Jonathan Kuminga and guard Buddy Hield, let you hear ESPN's Senior NBA Insider Shams Charania give his thoughts on the trade, react to what Shams had to say, and explain why they think the Hawks trading for Kuminga and Hield is a great low risk, high reward deal.
This episode of EM Pulse dives into one of the most stressful scenarios in the ED: the febrile infant in the first month of life. Traditionally, a fever in this age group has meant an automatic “full septic workup,” including the dreaded lumbar puncture (LP). But times are changing. We sit down with experts Dr. Nate Kuppermann and Dr. Brett Burstein to discuss a landmark JAMA study that suggests we might finally be able to safely skip the LP in many of our tiniest patients. The Study: A Game Changer for Neonates Our discussion centers on a massive international pooled study evaluating the PECARN Febrile Infant Rule specifically in infants aged 0–28 days. While previous guidelines were conservative due to a lack of data for this specific age bracket, this study provides the evidence we've been waiting for. The Cohort: A large pool of infants across multiple countries. The Findings: The PECARN rule demonstrated an exceptionally high negative predictive value for invasive bacterial infections. The Big Win: The rule missed zero cases of bacterial meningitis. Defining the Danger: SBI vs. IBI The experts break down why we are shifting our terminology and our clinical focus. Serious Bacterial Infection (SBI) Historically, this was a “catch-all” term including Urinary Tract Infections (UTIs), bacteremia, and meningitis. However, UTIs are generally more common, easily identified via urinalysis, and typically less life-threatening than the other two. Invasive Bacterial Infection (IBI) This term refers specifically to bacteremia and bacterial meningitis. These are the “high-stakes” infections the PECARN rule is designed to rule out. Dr. Kuppermann notes that we should ideally view bacteremia and meningitis as distinct entities, as the clinical implications of a missed meningitis case are far more severe. The HSV Elephant in the Room One of the primary reasons clinicians hesitate to skip an LP in a neonate is the fear of missing Herpes Simplex Virus (HSV) infection. Low Baseline Risk: While the overall risk of HSV in a febrile infant is low, the risk of “isolated” HSV (meningitis without other signs or symptoms) is even rarer. Screening Tools: Most infants with HSV appear clinically ill. Clinicians can also use ALT (liver function) testing as a secondary screen – transaminase elevation is a common marker for systemic HSV. Clinical Judgment: If the baby is well-appearing, has no maternal history of HSV, no vesicles, and no seizures, the risk of missing HSV by skipping the LP is exceptionally low. Practical Application: Shared Decision-Making This isn’t just about the numbers—it’s about the parents. “Families don’t mind their babies being admitted… They do not want the lumbar puncture. It is the single most anxiety-provoking aspect of care.” — Dr. Brett Burstein The PECARN “Low-Risk” Criteria: (Remember, this rule applies only to infants who are not ill-appearing.) Urinalysis: Negative Absolute Neutrophil Count (ANC): ≤ 4,000/mm³ Procalcitonin (PCT): ≤ 0.5 ng/mL The Bottom Line: If an infant is well-appearing and meets these criteria, physicians can have a nuanced conversation with parents about the risks and benefits of forgoing the LP, while still admitting the child for observation (often without empiric antibiotics) while cultures brew. Key Takeaways The “Well-Appearing” Filter: If an infant looks ill, the rule does not apply. These patients require a full workup, including an LP, regardless of lab results. Meticulous Physical Exam: Assess for a strong suck, normal muscle tone, brisk capillary refill, and any rashes or vesicles. History is Key: Always ask about maternal GBS/HSV status, pregnancy or birth complications, prematurity, sick contacts, and any changes in feeding, stooling or activity. Procalcitonin: PCT is the superior inflammatory marker for this rule. If your facility only offers traditional markers like CRP, the PECARN negative predictive value cannot be strictly applied. In the words of Dr. Kuppermann: “If you don’t have it, for God’s sakes, just get it! ALT to Screen for HSV: While not part of the official PECARN rule, our experts suggest that significantly elevated liver enzymes should raise suspicion for systemic HSV. Observe, Don’t Discharge: Being “low risk” does not mean the infant goes home. All infants ≤ 28 days still require admission for 24-hour observation and blood/urine cultures. We want to hear from you! Does this change how you approach febrile neonates in the ED? How do you handle shared decision-making with parents? Connect with us on social media @empulsepodcast or on our website ucdavisem.com. Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Professor of Emergency Medicine at UC Davis Guests: Dr. Nate Kuppermann, Executive Vice President and Chief Academic Officer; Director, Children’s National Research Institute; Department Chair, Pediatrics, George Washington University School of Medicine and Health Sciences Dr. Brett Burstein, Clinician-Scientist and Pediatric Emergency Medicine Physician at Montreal Children’s Hospital, McGill University Resources: Burstein B, Waterfield T, Umana E, Xie J, Kuppermann N. Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger. JAMA. 2026 Feb 3;335(5):425-433. doi: 10.1001/jama.2025.21454. PMID: 41359314; PMCID: PMC12687207“Hot” Off the Press: Infant Fever Rule “Hot” Off the Press: Infant Fever Rule Do I really need to LP a febrile infant with a UTI? PECARN Infant Fever Update: 61-90 Days Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections. JAMA Pediatr. 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. PMID: 30776077; PMCID: PMC6450281. Pantell RH, Roberts KB, Adams WG, Dreyer BP, Kuppermann N, O’Leary ST, Okechukwu K, Woods CR Jr; SUBCOMMITTEE ON FEBRILE INFANTS. Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old. Pediatrics. 2021 Aug;148(2):e2021052228. doi: 10.1542/peds.2021-052228. Epub 2021 Jul 19. Erratum in: Pediatrics. 2021 Nov;148(5):e2021054063. doi: 10.1542/peds.2021-054063. PMID: 34281996. ****Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services.
Join the conversation with C4 & Bryan Nehman. C4 & Bryan started the show this morning by discussing the congressional redistricting map vote. Homan to go to MN amid ongoing tensions with ICE. Could there be a low-risk grid event due to demand of energy with the cold weather. State Senator Christopher West joined the show discussing a possible state energy authority. There is outrage over the ICE facility viral video here in Baltimore. President of the state senate Bill Ferguson joined the show discussing a number of topics including redistricting, energy, if he and Governor Moore are cool & more. Listen to C4 & Bryan Nehman live weekdays from 5:30 to 10am on WBAL News Radio 1090, FM 101.5 & the WBAL Radio App!
Reference: Aronson PL, et al. Prediction Rule to Identify Febrile Infants 61–90 Days at Low Risk for Invasive Bacterial Infections. Pediatrics. September 2025 Date: January 6, 2026 Guest Skeptic: Dr. Jillian Nickerson is a pediatric emergency medicine attending at Children's National Hospital and Assistant Professor of Pediatrics and Emergency Medicine at The George Washington University […] The post SGEM#501: Here it Goes Again – Another Clinical Decision Rule for Febrile Infants 61-90 Days first appeared on The Skeptics Guide to Emergency Medicine.
EP 2753 (WE 304) Book Review Low-risk Entrepreneurship ตอนที่ 2 มาต่อเป็นตอนที่ 2 ของการรีวิวหนังสือเล่มนี้ซึ่งน่าจะเป็นประโยชน์กับผู้ประกอบการวันหยุดทุกท่านนะครับ
About this episode: Citing updated research on the health risks of drinking alcohol, Canada changed consumption guidelines in 2023, making global headlines for its steep drop in what's viewed as "low risk" drinking. In this episode: One of the architects of those guidelines explains how these recommendations were developed, their efficacy as a public health intervention, and what to make of the U.S.'s new guidelines. Guests: Tim Stockwell, PhD, is a scientist at the Canadian Institute for Substance Use Research and emeritus professor of psychology at the University of Victoria. Host: Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health. Show links and related content: US has new alcohol guidelines: How much is healthy to drink?—The Hill Is That Drink Worth It to You?—New York Times Canada's Guidance on Alcohol and Health—Canadian Centre on Substance Use and Addiction What's behind Canada's drastic new alcohol guidance—BBC Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @PublicHealthPod on Bluesky @PublicHealthPod on Instagram @JohnsHopkinsSPH on Facebook @PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.
EP 2746 (WE 303) Book Review Low-risk Entrepreneurship ตอนที่ 1 ตอนนี้มารีวิวหนังสือที่แนะนำการทำธุรกิจที่มีความเสี่ยงต่ำ ซึ่งน่าจะตรงกับเป้าหมายของการเป็นผู้ประกอบการวันหยุด ลองฟังกันได้ครับ
We review BRUEs (Brief Resolved Unexplained Events). Hosts: Ellen Duncan, MD, PhD Noumi Chowdhury, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/BRUE.mp3 Download Leave a Comment Tags: Pediatrics Show Notes What is a BRUE? BRUE stands for Brief Resolved Unexplained Event. It typically affects infants 60 days old Gestational Age: GA > 32 weeks (and Post-Conceptional Age > 45 weeks) Frequency: This is the first episode Duration: Lasted < 1 minute Intervention: No CPR performed by a trained professional Clinical Picture: Reassuring history and physical exam Management for Low Risk: Generally do not require extensive testing or admission. Prioritize safety education/anticipatory guidance. Ensure strict return precautions and close outpatient follow-up (within 24 hours). High Risk Criteria Any infant not meeting the low-risk criteria is automatically High Risk. Additional red flags include: Suspicion of child abuse History of toxin exposure Family history of sudden cardiac death Abnormal physical exam findings (trauma, neuro deficits) Management for High Risk: Requires a more thorough evaluation. Often requires hospital admission. Note: Serious underlying conditions are identified in approx. 4% of high-risk infants. Differential Diagnosis: “THE MISFITS” Mnemonic T – Trauma (Accidental or Non-accidental/Abuse) H – Heart (Congenital heart disease, dysrhythmias) E – Endocrine M – Metabolic (Inborn errors of metabolism) I – Infection (Sepsis, meningitis, pertussis, RSV) S – Seizures F – Formula (Reflux, allergy, aspiration) I – Intestinal Catastrophes (Volvulus, intussusception) T – Toxins (Medications, home exposures) S – Sepsis (Systemic infection) Workup & Diagnostics Step 1: Stabilization ABCs (Airway, Breathing, Circulation) Point-of-care Glucose Cardiorespiratory monitoring Step 2: Diagnostic Testing (For High Risk/Symptomatic Patients) Labs: VBG, CBC, Electrolytes. Imaging: CXR: Evaluate for infection and cardiothymic silhouette. EKG: Evaluate for QT prolongation or dysrhythmias. Neuro: Consider Head CT/MRI and EEG if there are concerns for trauma or seizures. Clinical Pearl: Only ~6% of diagnostic tests contribute meaningfully to the diagnosis. Be judicious—avoid “shotgunning” tests in low-risk patients. Prognosis & Outcomes Recurrence: Approximately 10% (lower than historical ALTE rates of 10-25%). Mortality: < 1%. Nearly always linked to an identifiable cause (abuse, metabolic disorder, severe infection). BRUE vs. SIDS: These are not the same. BRUE: Peaks < 2 months; occurs mostly during the day. SIDS: Peaks 2–4 months; occurs mostly midnight to 6:00 AM. Take-Home Points Diagnosis of Exclusion: You cannot call it a BRUE until you have ruled out obvious causes via history and physical. Strict Criteria: Stick strictly to the Low Risk criteria guidelines. If they miss even one (e.g., age < 60 days), they are High Risk. Education: For low-risk families, the most valuable intervention is reassurance, education, and arranging close follow-up. Systematic Approach: For high-risk infants, use a structured approach (like THE MISFITS) to ensure you don’t miss rare but reversible causes. Read More
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Do you want to know why note investing beats buying foreclosures? Scott Carson chats with one of his recent 1:1 coaching students, Sterling James, a CPA-turned-note investor who's mastered the art of turning distressed debt into serious profits.Sterling shares his journey from flipping houses to buying first lien notes, revealing his conservative approach, risk-minimizing tactics, and keys to success. If you're looking for a more passive, hands-off approach to real estate, this is the episode for you.The Secret CPA Advantage: How Understanding Taxes Gives You a HUGE Leg Up in InvestingLearn how Sterling's background in accounting and taxes provides a unique and powerful lens for evaluating deals, minimizing risk, and maximizing returns. Discover how his tax expertise helps him identify hidden opportunities.Back from the Brink: A Tale of Reinvention and Resilience in Real EstateSterling shares his candid story of facing financial challenges in the past and how he pivoted his investment strategy to find stability and consistent returns through note investing. A powerful lesson in adapting and thriving in any market!First Liens: Your Path to Low-Risk, High-Reward InvestingDiscover why Sterling focuses exclusively on first lien notes, providing maximum security and priority in case of foreclosure. Learn the specific criteria he uses to select notes, ensuring a high probability of success while minimizing potential losses.Case Study: The $45,000 Note That Turned into a WINGet a behind-the-scenes look at a recent deal where Sterling acquired a note for just $45,000 that's performing better than expected. Discover his due diligence process, his strategy for working with borrowers in bankruptcy, and how he generated impressive returns.Lazy Assets and Smart Collaboration:He's great at finding and building long-term passive investments and why you can do the same with Scott's 1:1 coaching.Ready to take control of your financial future and unlock the power of note investing? This episode is your roadmap to a more passive, profitable, and stress-free investment journey. Connect with Sterling James and his team at securedequities.com to learn more about partnering and putting your capital to work. Don't just dream of financial freedom – start building it today! And as always, don't forget to subscribe to The Note Closers Show for more expert insights, actionable strategies, and the real stories behind the success!Connect with Sterling HERE!Watch the Original VIDEO HERE!Book a Call With Scott HERE!Sign up for the next FREE One-Day Note Class HERE!Sign up for the WCN Membership HERE!Sign up for the next Note Buying For Dummies Workshop HERE!Love the show? Subscribe, rate, review, and share!Here's How »Join the Note Closers Show community today:WeCloseNotes.comThe Note Closers Show FacebookThe Note Closers Show TwitterScott Carson LinkedInThe Note Closers Show YouTubeThe Note Closers Show VimeoThe Note Closers Show InstagramWe Close Notes PinterestBook a call with Scott today at HTTP://TalkWithScottCarson.com to see if 1:1 Note Coaching is right for you!