Podcasts about sex differences

He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Dr. Nick Norwitz lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Dr. Nick Norwitz believes is coming in Alzheimer's gene therapy within the next decade. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The ApoE4 Paradox and the Case Report That Broke the Internet (00:00:57) Why Standard Omega-3 Supplements Fail and What to Take Instead (00:05:13) DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier (00:10:19) ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic (00:17:38) Why ApoE4 Carriers Burn Through DHA Faster and Need More (00:20:31) Women, Omega-3s, Menopause, and Brain Insulin Resistance (00:21:41) Statins, Sex Differences, and the DHA-Blood Sugar Connection (00:26:01) Statins and Dementia: What the Data Actually Say (00:32:24) Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology (00:42:19) The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance (00:45:21) Gene Editing, Prime Editing, and the Future of ApoE4 Therapy (00:49:33) Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data (00:55:10) The EZPAVE Trial: Why the Headlines Don't Hold Up (01:00:33) KetoneIQ: Ketones for Brain Energy and Focus (01:01:29) Cheers Health: Supporting Liver Function and Cognitive Recovery (01:03:54) If Not LDL, What Causes Heart Disease in Metabolically Healthy People? (01:12:05) The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism (01:19:10) Ketones, Women's Brains, and Clearing Misfolded Proteins (01:21:08) The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More (01:24:01) GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau (01:25:28) Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching (01:29:02) Why Nick Is Controversial And Why He Doesn't Mind _______ *Thank you to our sponsors*Fenix Health Science: fenixhealthscience.com Use code NEUROEXPPulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your orderFunction Health: https://www.functionhealth.com/louisanicolaBASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% offKetoneIQ: https://ketone.com/NEURO for 30% OFFCheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.instagram.com/louisanicola_/Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Nick lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Nick believes is coming in Alzheimer's gene therapy within the next decade. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The ApoE4 Paradox and the Case Report That Broke the Internet 00:57 Why Standard Omega-3 Supplements Fail and What to Take Instead 05:13 DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier 10:19 ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic 17:38 Why ApoE4 Carriers Burn Through DHA Faster and Need More 20:31 Women, Omega-3s, Menopause, and Brain Insulin Resistance 21:41 Statins, Sex Differences, and the DHA-Blood Sugar Connection 26:01 Statins and Dementia: What the Data Actually Say 32:24 Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology 42:19 The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance 45:21 Gene Editing, Prime Editing, and the Future of ApoE4 Therapy 49:33 Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data 55:10 The EZPAVE Trial: Why the Headlines Don't Hold Up 01:00:33 KetoneIQ: Ketones for Brain Energy and Focus 01:01:29 Cheers Health: Supporting Liver Function and Cognitive Recovery 01:03:54 If Not LDL, What Causes Heart Disease in Metabolically Healthy People? 01:12:05 The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism 01:19:10 Ketones, Women's Brains, and Clearing Misfolded Proteins 01:21:08 The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More 01:24:01 GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau 01:25:28 Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching 01:29:02 Why Nick Is Controversial And Why He Doesn't Mind _______ Thank you to our sponsors Fenix Health Science: fenixhealthscience.com Use code NEUROEXP Pulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your order Function Health: https://www.functionhealth.com/louisanicola BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off KetoneIQ: https://ketone.com/NEURO for 30% OFF Cheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

After reading something that said her menstrual cycle changes her brain each month, Senior Correspondent Molly Webster goes on a reporting mission to see if that's true, and, if so, how. This journey into sex hormones and the brain involves females and males, and exacting self-experimentation. It gets into PTSD, and ends with a new twist on self-care (hint: it's biological). And, it starts to reveal a sneaky truth: that each one of us is at the mercy of a crashing sea of chemicals inside of us – those things we call hormones. Special thanks to Emily Jacobs, Laura Pritschet, Pavel Shapturenka, and Dr. Catherine Woolley.EPISODE CREDITS: Hosted by - Molly Webster Reported by - Molly Webster Produced by - Mona Madgavkar with help from - Molly Webster Fact-checking by - Diane A. Kelly EPISODE CITATIONS: Articles -  **The experiments we feature in this episode are called: 28andMe, 28andOC, and 28andHe, all of which took place at Emily Jacobs lab at the University of California, Santa Barbara.**  The 28 Project (https://zpr.io/CSx6MnwZjRvp), background from the Jacobs lab For more on how much variability there is between female and male animals, check out this “groundbreaking” study, referenced by Emily Jacobs in our episode Sex Bias in Neuroscience and Biomedical Research(https://zpr.io/ZRgKZzdNejUA),  by Beery AK, Zucker I., Neurosci Biobehav Rev. 2011 Dr. Catherine Woolley has revolutionized the field of neuroscience and sex hormones, here's more about her work … Sex Differences in the Brain Get Down to the Molecular Level Sex (https://zpr.io/UNCLE9J782N5), by Stephanie DeMarco, PhD, The Scientist.com Hormonal Effects on the Brain (https://zpr.io/DvNM9EkXdtGG), by Woolley, C.S. and Schwartzkroin, P.A. Epilepsia Data sets - 28andMe and 28andOC (https://zpr.io/hbXVNTVp2Q7j): 28andHe (https://zpr.io/sZXhfMbMwKb7) Audio -  In the episode, we mention Dr. Russ Poldrack and the Midnight Scan Club, as inspo for self-experimentation The Midnight Scan Club (https://zpr.io/CLBhNQSxK844), by Science Friday.   Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab's science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

"We typically think of the disease progressing for our higher-risk patients because many of them already start with increased blasts or a lot of dysplasia. And they have these chromosomal variants that make them prone to evolving into acute myeloid leukemia (AML). With them, we can anticipate that they are going to progress to AML. And that's what we're trying to prevent. It's kind of like a biologic evolution and not a switch," ONS member Sara Tinsley-Vance, PhD, APRN, AOCN®, nurse practitioner and quality-of-life researcher at Moffitt Cancer Center in Tampa, FL, told Lenise Taylor, MN, RN, AOCNS®, TCTCN™, oncology clinical specialist at ONS, during a conversation about long-term myelodysplastic syndrome (MDS) considerations for oncology nurses. Music Credit: "Fireflies and Stardust" by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0  Earn 0.75 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by June 19, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to management of long-term side effects related to myelodysplastic syndrome and its treatment. Episode Notes  Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Episode 415: Myelodysplastic Syndrome Treatment Considerations for Oncology Nurses Episode 411: An Overview of Myelodysplastic Syndrome for Oncology Nurses Episode 256: Cancer Symptom Management Basics: Hematologic Complications Episode 220: Oncologic Emergencies 101: Febrile Neutropenia and Sepsis Clinical Journal of Oncology Nursing articles:  Exploring Experiences of Bereaved Caregivers of Older Adult Patients With Acute Myeloid Leukemia Family Caregiver Preparedness: Developing an Educational Intervention for Symptom Management Incorporating Nurse Navigation to Improve Cancer Survivorship Care Plan Delivery Oncology Nursing Forum article: An Integrative Review of Sex Differences in Quality of Life and Symptoms Among Survivors of Hematologic Malignancies ONS book: BMTCN® Certification Review Manual (second edition) ONS course: Psychosocial Dimensions of Cancer Care™  ONS Learning Libraries:  Survivorship Learning Library Hematology, Cellular Therapy, and Stem Cell Transplantation Survivorship Care Plan Huddle Card American Association of Colleges of Nursing End-of-Life Nursing Education Consortium (ELNEC) American Cancer Society: Living As a Myelodysplastic Syndrome Survivor American Society of Hematology Aplastic Anemia and MDS International Foundation: MDS Toolkit Blood Cancer United: Myelodysplastic Syndromes Family Caregiver Alliance HealthTree Foundation Inspire: MDS Support and Discussion Community Myelodysplastic Syndromes Foundation To discuss the information in this episode with other oncology nurses, visit the ONS Communities.  To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode "When our higher-risk patients have disease-related progression, their [malignancy] can transform to AML. And we know this occurs in about one-third of our patients and is one of the most serious late effects. Even in lower-risk disease, we have this worsening marrow failure with or without increasing blast, where [patients] may have just started out with anemia, then they also develop neutropenia and thrombocytopenia. And as those counts worsen, we usually know that their disease is progressing." TS 2:47 "The golden rule is looking at the blood count but also looking at the patient and how they're doing over time. The backbone of MDS monitoring is the complete blood cell count with the differential. What you're looking for is trends over time. How many units of blood are they receiving, what threshold are you going to transfuse them at, and how many units of blood are they getting at a time? ... And then paying attention to the absolute neutrophil count for infection risk. [Another] really important piece of when you look at the differential with patients is seeing if they have any abnormal cell counts. Do they have circulating blasts? Are those monocytes going up? If you start to see blasts circulating or increasing monocytes, then their disease could be changing, even if they have low-risk disease." TS 15:58 "For lower-risk disease, we're paying more attention to their quality of life, how the patient's tolerating therapy, trying to help them stay safe over the long haul, and starting them on iron chelation if it matches that patient and they can have access to those drugs. ... For higher-risk disease, if the patient's goal is to be cured and not to progress to AML, you want to get them to transplant if that's [also] one of their goals. If they do evolve into AML, try and see what treatment matches best for them." TS 22:28 "You want to start early for patients who have febrile neutropenia—that's really important when a patient is an hour or two away from a center where they can get started on antibiotics. So, you have to think outside the box. What can we do to keep them safe? ... I know this group in Alaska that's in our advisory meetings and they try to facilitate transportation to Seattle. That's the closest academic center to them. Collaborating with telemedicine appointments, starting earlier, developing that strong relationship with patients, and contacting them between visits [can help patients living in rural areas]." TS 25:22 "I think the biggest [psychosocial challenge] I see is a lot of unmet anxiety and depression counseling. A lot of times, [patients are] losing their place in their family because they're the ones that need all the help now. Also, the uncertainty that goes along with the diagnosis. There is communication skills counseling, and End-of-Life Nursing Education Consortium (ELNEC) has a lot of training for communication skills and how to really talk to patients. Not that we take the place of a psychologist, but just being able to talk to somebody can go a long way. And if we can get training for that, we can help more patients." TS 31:15

The science of sex differences is intensely political. Traditionalists tend to exaggerate the innate differences between men and women, while progressives tend to minimise them, arguing that the behavioural differences we see between the sexes are a product of nurture, rather than nature. Steve Stewart-Williams wants to offer a more cautious assessment. There are a lot of average differences between the sexes, some of them very pronounced. There are also a lot of small to moderate differences that are visible at the population level, but not necessarily at the individual level. This is a controversial subject, but also an enormously interesting one, with obvious relevance to all of our lives. Steve Stewart-Williams is a professor of psychology at the University of Nottingham Malaysia and author of books including 'Darwin, God, and the Meaning of Life' and 'The Ape That Understood the Universe.' His latest book is titled 'A Billion Years of Sex Differences: How Evolution Shaped the Minds of Men and Women.' Hosted on Acast. See acast.com/privacy for more information.

******Support the channel******Patreon: https://www.patreon.com/thedissenterPayPal: paypal.me/thedissenterPayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuyPayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9lPayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpzPayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9mPayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ******Follow me on******Website: https://www.thedissenter.net/The Dissenter Goodreads list: https://shorturl.at/7BMoBFacebook: https://www.facebook.com/thedissenteryt/Twitter: https://x.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Steve Stewart-Williams is Professor of Psychology at University of Nottingham Malaysia. His research revolves around the idea that theories from evolutionary biology can shed light on human psychology. In particular, he's interested in the evolutionary origins of altruistic behavior and human sex differences. His latest book is A Billion Years of Sex Differences: How Evolution Shaped the Minds of Men and Women. In this episode, we focus on A Billion Years of Sex Differences. We start by discussing what sex differences are, why they matter, and the best ways of studying them. We talk about people who minimize or exaggerate sex differences, and five positions in the nature-nurture debate surrounding sex differences. We discuss limitations with behavioral genetics, cross-cultural evidence, and cross-species evidence. We talk about the most robust sex differences, and we debate educational and occupational choices. We discuss whether sex differences can be compatible with feminism. We talk about the evolution of sex differences. We discuss how to think about intersex people, trans people, and non-binary people. Finally, we talk about the best approach to deal socially with sex differences.--A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, JOÃO BARBOSA, JULIAN PRICE, HEDIN BRØNNER, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, DAN SPERBER, ROBERT GRESSIS, JEFF MCMAHAN, JAKE ZUEHL, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, VALENTIN STEINMANN, ALEXANDER HUBBARD, BR, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, MAURO JÚNIOR, TONY BARRETT, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, TED FARRIS, HUGO B., JORDAN MANSFIELD, CHARLOTTE ALLEN, PETER STOYKO, DAVID TONNER, LEE BECK, PATRICK DALTON-HOLMES, NICK KRASNEY, RACHEL ZAK, DENNIS XAVIER, CHINMAYA BHAT, RHYS, ALEX MACLEOD, HAIDAR, JULIEN PORCHER, ROBERT SUNDSTRÖM, JON STEWART, AND JENNY M!A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, NICK GOLDEN, CHRISTINE GLASS, IGOR NIKIFOROVSKI, PER KRAULIS, ADAM HUNT, AND JOÃO BARBOSA!AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER,SERGIU CODREANU, AND GREGORY HASTINGS!

Yascha Mounk and Steve Stewart-Williams examine what science reveals about biological and psychological differences between men and women. Steve Stewart-Williams is a professor of Psychology at the University of Nottingham's Malaysia campus and runs The Nature-Nurture-Nietzsche Newsletter. His latest book is A Billion Years of Sex Differences. In this week's conversation, Yascha Mounk and Steve Stewart-Williams discuss why women and men are more similar than is often thought and what the real sex differences between men and women are, from casual sex to career choices. If you have not yet signed up for our podcast, please do so now by following ⁠this link on your phone⁠. Email: leonora.barclay@persuasion.community Podcast production by Jack Shields and Leonora Barclay. Connect with us! ⁠Spotify⁠ | ⁠Apple⁠ | ⁠Google⁠ X: ⁠@Yascha_Mounk⁠ & ⁠@JoinPersuasion⁠ YouTube: ⁠Yascha Mounk⁠, ⁠Persuasion⁠ LinkedIn: ⁠Persuasion Community Learn more about your ad choices. Visit megaphone.fm/adchoices

In the final episode, the focus turns to prevention. Rachel Buckley examines whether Alzheimer's strategies should be sex-specific, the timing of interventions, and how lifestyle factors like physical activity contribute to brain resilience. The discussion also highlights gaps in research and the need for better integration of women's health data. Timestamps: 00:00:45:13 – Sex-disaggregated data for prevention 00:03:26:15 – Sex-specific timing for therapeutics 00:05:07:20 – Non-pharmacological interventions 00:07:58:02 – Gaps in reproductive data

This episode explores how reproductive ageing and biological sex influence Alzheimer's disease risk. Rachel Buckley discusses menopause, hormonal changes, genetic factors such as the X chromosome, and emerging evidence showing differences in tau accumulation between women and men. Timestamps: 00:00:55:03 – Menopause and Alzheimer's disease 00:04:51:11 – X chromosome in Alzheimer's disease 00:08:29:01 – Tau accumulation in women 00:10:43:09 – Hormone replacement therapy 00:14:22:24 – The sweet spot with hormone therapy

This episode explores how reproductive ageing and biological sex influence Alzheimer's disease risk. Rachel Buckley discusses menopause, hormonal changes, genetic factors such as the X chromosome, and emerging evidence showing differences in tau accumulation between women and men. Timestamps: 00:00:55:03 – Menopause and Alzheimer's disease 00:04:51:11 – X chromosome in Alzheimer's disease 00:08:29:01 – Tau accumulation in women 00:10:43:09 – Hormone replacement therapy 00:14:22:24 – The sweet spot with hormone therapy

In the final episode, the focus turns to prevention. Rachel Buckley examines whether Alzheimer's strategies should be sex-specific, the timing of interventions, and how lifestyle factors like physical activity contribute to brain resilience. The discussion also highlights gaps in research and the need for better integration of women's health data. Timestamps: 00:00:45:13 – Sex-disaggregated data for prevention 00:03:26:15 – Sex-specific timing for therapeutics 00:05:07:20 – Non-pharmacological interventions 00:07:58:02 – Gaps in reproductive data

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

In this first deep dive, Rachel Buckley joins host Catherine Glass to explore how Alzheimer's disease risk can be detected before symptoms appear. From blood-based biomarkers like p-tau217, to AI-driven models of cognitive resilience, the episode examines how risk, progression, and protection can be better understood and predicted over time. Timestamps: 00:00:57:11 – Phosphorylated tau and amyloid-PET 00:08:15:05 – Biomarkers, risk, and progression 00:11:18:04 – Brain resistance and cognitive resilience 00:15:23:23 – AI biases

In this rapid-fire episode, Rachel Buckley answers key questions on Alzheimer's disease, covering sex differences in risk, early predictors of progression, brain resilience, and the most actionable prevention strategies. A concise overview of the evolving science behind personalised Alzheimer's care.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Cardiac Involvement in Adults With Myotonic Dystrophy Type 1: A Multicenter Study.

In this episode of The Athletes Compass, Paul Warloski, Dr. Paul Laursen, and Marjaana Rakai explore recovery strategies for everyday endurance athletes, emphasizing that sleep and nutrition remain the foundation while tools like cold water immersion, sauna, compression garments, massage guns, foam rolling, forest bathing, and active recovery can all have a place depending on context. The conversation highlights how cold and heat therapies may support mental clarity, resilience, and heat adaptation, while nature exposure and low-intensity movement can help restore the nervous system. The hosts also discuss gender differences in recovery, especially the mental load and sleep disruptions many women experience, and identify red flags of under-recovery such as declining HRV, flat mood, loss of motivation, and reduced joy in training.Key TakeawaysSleep and nutrition are the “big rocks” of recovery; everything else is a smaller tool to use strategically.Cold water immersion can help with mental reset and acute inflammation, but it may not always be ideal after strength work or heat-adaptation sessions.Sauna and heat exposure can support plasma volume expansion, cardiovascular adaptation, and mental resilience.Compression gear may be most useful in specific contexts, such as travel, swelling, plantar fasciitis, or after hard race weekends.Massage guns, foam rollers, balls, stretching, and massage therapy are all useful ways to pay attention to muscle tone and tightness.Forest bathing and time in nature may support mood, immunity, parasympathetic activity, and nervous system recovery.Women may not necessarily recover differently physiologically, but lifestyle load, hormonal changes, sleep disruption, and the “third shift” can affect recovery capacity.Red flags of under-recovery include low or abnormal HRV trends, loss of motivation, lack of joy, persistent heaviness, poor sleep, and mood changes.Active recovery can sometimes be better than complete rest, especially when it involves gentle movement, time away from screens, or lower-impact modalities.Running is often more neuromuscularly stressful than cycling, swimming, or rowing, so changing modality can help maintain movement while reducing load.Sex Differences in Self-Reported Causes, Symptoms, and Recovery Strategies Associated With Underperformance in Endurance AthletesRandomized controlled trial on the efficacy of forest walking compared to urban walking in enhancing mucosal immunity | Scientific ReportsIsolated and Combined Effects of Cold, Heat and Hypoxia Therapies on Muscle Recovery Following Exercise-Induced Muscle Damage | Sports Medicine | Springer Nature LinkPaul Warloski - Simple Endurance CoachingMarjaana Rakai | Nordic Performance Lab

Women are more likely to diet for fat loss than men.But they're also more likely to run into challenges that make the process feel frustrating, confusing, and harder to sustain.In this episode of the Chasing Clarity Health & Fitness Podcast, I'm joined by Lyle McDonald for a deep dive into the topic of female fat loss.Lyle has been writing about fitness, nutrition, dieting, and female physiology for decades, and in this episode we unpack the physiological, behavioral, and practical reasons why fat loss can be more difficult for women.We cover the most common mistakes women make when dieting, why women often lose scale weight slower than men, how sex differences in metabolism, energy expenditure, fat storage patterns, and lean mass retention impact fat loss outcomes, and why aggressive low-calorie dieting can create bigger problems for women.This episode is not about fear mongering or making women feel like their bodies are broken.It's about helping women understand their physiology so they can take a smarter, more strategic approach to fat loss.HERE IS WHAT WE COVER:THE MOST COMMON FAT LOSS MISTAKES WOMEN MAKEWHY AGGRESSIVE DIETING OFTEN BACKFIRESSEX DIFFERENCES IN METABOLISM & ENERGY EXPENDITUREWHY WOMEN LOSE WEIGHT SLOWER THAN MENDIFFERENCES IN FAT STORAGE PATTERNS BETWEEN MEN & WOMENTHE TRUTH BEHIND THE 3500 CALORIE RULEWHY WOMEN MAY LOSE LESS LEAN MASS DURING A DIETLOW ENERGY AVAILABILITY & RELATIVE ENERGY DEFICIENCYWHY VERY LOW-CALORIE DIETS CAN BE MORE PROBLEMATIC FOR WOMENIf you found this episode helpful, share it with someone who needs to hear it.WHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/Email: Bdacruzfitness@gmail.comFor Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiry

The results mark a “dramatic shift” in how neuroscientists think about sex differences, and they may help explain sex biases in certain neurodegenerative and neurodevelopmental conditions.

Dr. Jennifer Roback Morse, founder and president of the Ruth Institute, joins Trending with Timmerie Episode Guide Can kids have talk therapy without government interference? SCOTUS rules against conversion therapy ban in Colorado (2:28) Leaving pride behind, research published (19:17) Priest in Lebanon shows the impact on a war-torn nation and the hope we have in God (34:57) 8 Planned Parenthood’s close this year – are abortion numbers really going up? (43:26) Resources mentioned: https://ruthinstitute.org/ Supreme Court Counseling Freedom Case https://ruthinstitute.org/counseling-freedom-for-all/ruth-institute-applauds-supreme-court-counseling-freedom-case/ Peer reviewed research: Sex Differences in Reported Effectiveness and Psychosocial Effects of Therapy-Assisted Sexual Orientation Change https://www.cureus.com/articles/461628-sex-differences-in-reported-effectiveness-and-psychosocial-effects-of-therapy-assisted-sexual-orientation-change#!/ Leaving Pride Behind: https://39617564.hs-sites.com/en/fighting-to-leave-pride-behind Study – No one is born gay. There is no gay gene https://www.science.org/doi/10.1126/science.aat7693

In this episode, Dr. Puder sits down with Franciska de Beer, MSc, first author of landmark HAMLETT-OPHELIA Consortium papers in JAMA Psychiatry, World Psychiatry, and Psychological Medicine. They dive deep into the psychiatrist effect in first-episode psychosis, revealing that individual psychiatrists explain approximately 10% of variance in positive symptom improvement and daily functioning, even after controlling for medication dose. The conversation explores groundbreaking HAMLETT findings on early antipsychotic tapering versus maintenance, dopamine supersensitivity after high-affinity D2 blockers, sex differences in treatment outcomes and clozapine levels during menopause, and why shared decision-making and reflective functioning matter more than ever in psychosis care.   By listening to this episode, you can earn 1.25 Psychiatry CME Credits. Link to blog Link to YouTube video

Dr. Marc Breedlove, PhD, is a professor of neuroscience at Michigan State University and an expert on how hormones shape brain development and sexual orientation. We discuss how prenatal testosterone impacts whether someone is romantically attracted to men or women later in life, and what correlates of sexual orientation — such as finger-length ratios — tell us about the role of hormones in brain and psychological development. We also discuss why the number of older brothers a male has biases sexual orientation. Throughout, we explain how nature and nurture interact to shape male-female differences, behavior, and romantic partner choice. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Rorra: https://rorra.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Marc Breedlove (00:03:24) Hormones & Sexual Orientation (00:07:37) Prenatal Testosterone, Finger Ratio, Men & Women Differences (00:14:08) Sponsors: David & Rorra (00:16:46) Finger Ratios, Prenatal Testosterone, Gay & Straight Men/Women (00:23:57) Mice & Sex Differences, Androgens (00:26:54) Brain Differences & Sexual Orientation (00:33:52) Group vs Individual Differences, Height Analogy; Bisexuality (00:36:57) Brain Development, Hormones & Behavior; Brain Plasticity (00:42:52) Sponsor: AG1 (00:44:16) Sexual Behavior, Libido (00:51:37) Gay Rams, Brain Differences (00:58:00) Aversion Pathway, Men vs Women, Same-Sex Partner (01:06:58) Congenital Adrenal Hyperplasia (CAH), Intersex Phenotypes (01:13:55) Androgen Insensitivity Syndrome (AIS) (01:18:14) Sponsor: Function (01:19:25) Gay Men & Older Brothers, Maternal Immunization Hypothesis (01:32:55) CAH Carriers, Advantage, Stress Tolerance (01:35:41) Birds & Sexual Differentiation, Gynandromorphs (01:41:32) Anabolic Steroids, Hypersexuality; Adult Brain Plasticity (01:45:31) Age & Testosterone Decline; Sexual Orientation & Activities (01:53:14) Marc's Academic Journey, Ozarks, Luck (02:02:35) Exploration; Kids & Sex Differences (02:08:47) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Hay cosas que cambian por dentro mucho antes de hacerse visibles. Y el corazón es una de ellas.En este episodio de Hace calor y soy yo, hablamos de uno de los temas más importantes —y menos presentes— en la conversación sobre perimenopausia y menopausia: la salud cardiovascular en la mujer. Nos acompaña la Dra. Leticia Fernández-Friera, cardióloga, jefa de servicio de cardiología en HM Hospitales (HM CIEC), fundadora de ATRIA Clinic y reconocida en Forbes 100 Mejores Médicos 2024. Una mirada clara, útil y sin dramatismos a cómo cambian el colesterol, la tensión arterial y el riesgo cardiovascular en esta etapa, y a todo lo que sí podemos hacer para cuidar el corazón con más información, más criterio y una idea más completa de lo que significa cuidarse bien. En este episodio hablamos de: • Perimenopausia, hormonas y salud cardiovascular • Colesterol, tensión arterial y riesgo invisible • El corazón de la mujer: lo que cambia en esta etapa • Hábitos cotidianos que sí marcan la diferencia • Cómo cuidarte mejor con información, prevención y criterio Porque cuando hablamos de bienestar, también hablamos de todo eso que no siempre se ve, pero también importa. Gracias a Danacol por acompañarnos en este episodio y por ayudar a visibilizar un tema tan importante como es la relación entre menopausia, colesterol y salud cardiovascular.

In this special TIO Congress edition of Parallax, Dr Ankur Kalra is joined by two of interventional cardiology's most influential voices: Professor Roxana Mehran, incoming President of the American College of Cardiology and Co-Course Director of TIO, and Professor Nicholas Van Mieghem, TIO Course Director. The conversation spans the evolution of online medical education, sex-specific differences in cardiovascular disease, and the challenge of translating clinical evidence into everyday practice. The guests explore sex as a biological variable across valve disease, plaque formation, and left ventricular remodeling, address the underdiagnosis of microvascular dysfunction in women, and examine persistent access barriers for female and non-white patients despite advances in trials such as SMART and RHEA. Professor Van Mieghem adds insights on modern TAVI planning and lifetime valve management, while Professor Mehran shares promising data on Factor XI inhibitors and the case for simplifying antithrombotic regimens. The episode closes on clinical inertia - with intravascular imaging uptake in the US still at just 12–15% despite a Class 1 indication, Professor Mehran outlines her ACC presidential vision: closing the gap between evidence and bedside practice, and reversing the troubling rise in cardiovascular morbidity and mortality. Questions and comments can be sent to podcast@radcliffe-group.com and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

Zone two has been sold to you as the gold standard for mitochondrial health, fat burning, and longevity. But what if it was built on culture, not science. In this episode, I sit down with Kristi Storoschuk, a PhD researcher whose work is challenging some of the biggest claims in the exercise world right now. We break down why zone two training lacks the scientific evidence everyone assumes it has, why higher intensity zones three and four are actually more potent for mitochondrial adaptation, and why the 80/20 training split from elite athletes was never designed for someone exercising four days a week. We also get into why fasting doesn't activate the same cellular pathways in humans as it does in rodents, why cortisol from exercise is not the same as chronic stress, the truth about fasted exercise for women, and what lactate actually tells us about our metabolic health. Kristi also shares her current research in collaboration with Dr. Andy Galpin and Dr. Tommy Wood on whether lactate threshold can serve as a non-invasive proxy for mitochondrial content. This conversation will completely change how you think about every cardio session you've ever done. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Was Zone Two Built on Culture, Not Science? 03:19 The Three Exercise Intensity Domains (Not Five Zones) 08:00 Zone Two and Fat Burning: What the Research Actually Shows 12:00 Why Women Are Being Scared Away from Zone Three and Four 20:45 Fasting in Rodents vs. Humans: The Research That Changed Everything 24:00 Fasted Exercise and Cortisol: The Real Story for Women 29:00 What Lactate Actually Tells Us About Mitochondrial Health 37:00 VO2 Max, Mitochondria, and Longevity 43:30 Exercise as Your Daily Metabolic Reset 49:00 The Best Cardio Prescription for Healthspan 55:30 How a 73 Year Old Should Think About High Intensity 58:00 How to Know What Zone You're In Without a Monitor 01:02:00 Sex Differences in Exercise: What the Data Actually Says _______ Thank you to our sponsors Function health: https://www.functionhealth.com/louisanicola Timeline: http://timeline.com/NEURO Jones Road Beauty: https://www.jonesroadbeauty.com And Use code NEURO Lifeboost coffee : https://lifeboostcoffee.com/ and Use code NEURO for 10% off Just Thrive: https://justthrivehealth.com/NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Bei kleinen Streits sofort Schluss machen – Tatjana kennt diesen Impuls nur zu gut. Im Nachhinein bereut sie es dann. Ein Psychologe erklärt, wie wir erkennen, ob wir uns wirklich trennen wollen, und was hilft, um im Konflikt nicht alles hinzuwerfen.**********Ihr hört: Gesprächspartnerin: Tatjana, macht in Streits schnell Schluss und bereut es danach Gesprächspartner: Ramón Schlemmbach, klinischer Psychologe (M. Sc.), systemischer Paartherapeut und Heilpraktiker für Psychotherapie Gesprächspartnerin: Louisa Scheling, Psychologin, Paartherapeutin und Doktorandin im Fach Persönlichkeitspsychologie mit Schwerpunkt Paarforschung an der Universität Freiburg Autorin: Shalin Rogall Redaktion: Yevgeniya Shcherbakova, Sarah Brendel, Anne Bohlmann, Friederike Seeger Produktion: Jan Morgenstern**********Quellen:Le, B., Dove, N. L., Agnew, C. R., Korn, M. S., & Mutso, A. A. (2010). Predicting nonmarital romantic relationship dissolution: A meta-analytic synthesis. Personal Relationships, 17(3), 377–390.DeLecce, T., Weisfeld, G. An Evolutionary Explanation for Sex Differences in Nonmarital Breakup Experiences. Adaptive Human Behavior and Physiology 2, 234–251 (2016).Rosenfeld, M. J. (2018). Who wants the breakup? Gender and breakup in heterosexual couples. In D. F. Alwin, D. H. Felmlee, & D. A. Kreager (Eds.), Social networks and the life course: Integrating the development of human lives and social relational networks (pp. 221–243). Springer International Publishing/Springer Nature.Bravo, V., Connolly, J., & McIsaac, C. (2017). Why Did It End? Breakup Reasons of Youth of Different Gender, Dating Stages, and Ages. Emerging Adulthood, 5(4), 230-240.Meyer, D., & Sledge, R. (2022). The Relationship Between Conflict Topics and Romantic Relationship Dynamics. Journal of Family Issues, 43(2), 306-323.**********Mehr zum Thema bei Deutschlandfunk Nova:Trennung: Wie wir eine Beziehung gut beenden Alles neu: Warum eine Trennung manchmal genau richtig istWohnen mit Ex: Zusammenleben nach Trennung**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Meldet euch!Ihr könnt das Team von Facts & Feelings über Whatsapp erreichen.Uns interessiert: Was beschäftigt euch? Habt ihr ein Thema, über das wir unbedingt in der Sendung und im Podcast sprechen sollen?Schickt uns eine Sprachnachricht oder schreibt uns per 0160-91360852 oder an factsundfeelings@deutschlandradio.de.Wichtig: Wenn ihr diese Nummer speichert und uns eine Nachricht schickt, akzeptiert ihr unsere Regeln zum Datenschutz und bei Whatsapp die Datenschutzrichtlinien von Whatsapp.

Join Professor Iain McInnes for the latest episode of Discussing RA on The Immune-Mediated Inflammatory Disease Forum. In this episode, he will review a paper by Strand et al. that evaluated TOF efficacy, safety, and persistence by sex, and explored whether age-related factors contribute to differences in treatment response between males and females, and by Alten et al. that explored the long‑term effectiveness of baricitinib and other b/tsDMARDs in patients with RA with early low disease activity or remission.

Sex Differences in Asthma: What Genomics Can Teach Us

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in the Clinical Recognition of Significant Aortic Stenosis.

Howie and Harlan are joined by Basmah Safdar, a Yale School of Medicine emergency physician and an expert on sex-specific differences in cardiovascular and microvascular health, which have important implications for the understanding and treatment of heart attacks, long COVID, and other conditions. Harlan reports on Australia's ban on social media for kids, and a Medicare pilot program that will pay providers based on improved outcomes in chronic conditions. Howie unpacks the consequences of the CDC's change to its recommendations for newborn hepatitis B vaccination. Show notes: Social Media and Kids "Australia's Social Media Ban for Children Takes Effect" Health & Veritas Episode 197: Peter Hotez: Mapping the Anti-Science Machine Medicare's ACCESS Payment Model CMS: ACCESS (Advancing Chronic Care with Effective, Scalable Solutions) Model Basmah Safdar "Medical School Enrollment Reaches 100,000 Students for the First Time" Health & Veritas: Episode 176: Live at the Yale Innovation Summit 2025 "Myocardial ischemia in women: lessons from the NHLBI WISE study" "Sex Differences in COVID-19 Immune Responses Affect Patient Outcomes" "Scientists unravel mystery of sex disparities in COVID-19 outcomes" Health & Veritas Episode 192: Akiko Iwasaki: What Have We Learned About Long COVID? "Basmah Safdar, MD, FACEP, Appointed Director, Women's Health Research at Yale (WHRY)" Women's Health Research at Yale "Women's Health Research at Yale: The Prologue" "History of Women's Participation in Clinical Research" "Policy: NIH to balance sex in cell and animal studies" "Heart attack symptoms often misinterpreted in younger women" Harlan Krumholz: "Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients" "Women's Health: More Than 'Bikini Medicine'" "Celebrating Carolyn Mazure" "Women's Health Research at Yale: Our Research"  "Current Status of Gender and Racial/Ethnic Disparities Among Academic Emergency Medicine Physicians" "New Women's Health Fund of Funds Launches to Activate $60B in Life Sciences Capital" "Closing the women's health gap: A $1 trillion opportunity to improve lives and economies" "Blueprint to close the women's health gap: How to improve lives and economies for all" "Gates Foundation pledges $2.5 billion to women's health initiatives" "Milken Institute Launches New Women's Health Network, Former First Lady Jill Biden Joins as its Chair" Women's Health Research at Yale: Pilot Project Program Funding Note: Deadline is December 22. Women's Health Research at Yale: Collaborative CDC and Hepatitis B "Panel Votes to Stop Recommending Hepatitis B Shots at Birth for Most Newborns" CDC: Hepatitis B Vaccine Safety WHO: Hepatitis B "New review finds no evidence to support delaying universal hepatitis B birth-dose vaccination" In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time. Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings. Email Howie and Harlan comments or questions.

What is the main driver of sex differences in heart failure with reduced ejection fraction (HFrEF)? In our latest episode, Associate Editor Dr. Petra Kleinbongard (University of Duisburg-Essen) interviews lead author Dr. Matthieu Ruiz (Montreal Heart Institute) and expert Dr. Catherine Mounier (Université du Québec à Montréal) about the new study by David et al. that explores sex-specific effects of B-vitamin supplementation on heart failure with reduced ejection fraction in mice subjected to pressure overload. The research by Ruiz and co-authors found that B-vitamins improved survival rates, cardiac function, and reduced fibrosis in female mice. However, male mice exhibited persistent inflammation, fibrosis, and unfavorable lipidome remodeling despite the B-vitamin supplementation. The findings underscore the sex-specific benefits of B-vitamins in heart failure, and confirm the importance of animal models of human disease for clinical translation. Listen now and learn more.   Chloé David, Sonia Deschênes, Gabriel Ichkhan, Caroline Daneault, Isabelle Robillard Frayne, Bertrand Bouchard, Anik Forest, Yan Fen Shi, Marie-Ève Higgins, Martin G. Sirois, Jean-Claude Tardif, Mathias Mericskay, Jérôme Piquereau, and Matthieu Ruiz Sex-Specific Modulation of Cardiac Fibrosis and Lipid Metabolism by B-Vitamins in Heart Failure with Reduced Ejection Fraction in Mice Am J Physiol Heart Circ Physiol, published June 12, 2025. DOI: 10.1152/ajpheart.00841.2024

This is a free preview of a paid episode. To hear more, visit andrewsullivan.substack.comCory is a behavioral scientist, the executive director of the Adversarial Collaboration Project at Penn, a visiting scholar at Penn, and an associate professor of psychology at New College of Florida. She's also been Director of Academic Engagement for Heterodox Academy and an assistant professor of behavioral science at Durham University. We talk sex differences and the recent essay, “The Great Feminization,” by Helen Andrews.For two clips of our convo — on the female dominance in education, and the growing power of HR — head to our YouTube page.Other topics: growing up in a big Catholic family in Ohio; her mom a gym teacher and dad a school psychologist; the culture shock of higher ed; the different evolutionary challenges of men and women; “warriors vs worriers”; the Big Five personality traits; neuroticism and risk-aversion; the male sex drive and propensity for violence; the gendered reaction to controversial ideas; safe spaces; The Coddling of the American Mind; extended adolescence; grade inflation; anonymous reporting systems; the boom of the mental health industry; the rise of the parenting industry; women in the military; mediocre men replaced by competent women in the workforce; MeToo; the decline of yelling in newsrooms; Puritanism; aggressive nuns; Prohibition; the Larry Summers row over women in science; the hostility toward men in higher ed; young men becoming reactionary; fairness in sports and locker rooms; the DEI industry; Harris and Walz; and Trump as a crude parody of an idiot male.Browse the Dishcast archive for an episode you might enjoy. Coming up: Fiona Hill on Putin's war, Mark Halperin on US politics, Michel Paradis on Eisenhower, Vivek Ramaswamy on the right, Jason Willick on trade and conservatism, Shadi Hamid on US power abroad, George Packer on his Orwell-inspired novel, and Arthur Brooks on the science of happiness. As always, please send any guest recs, dissents, and other comments to dish@andrewsullivan.com.

This episode is sponsored by Relay. For a 7 day free trial, go to https://joinrelay.app/maiden and use the code ‘LOUISE' at checkout.

In this episode, evolutionary biologist Colin Wright joins the show to explore the clash between biological science and modern gender ideology. He shares his experiences working at a think tank, navigating academic censorship, and challenging politically driven narratives about sex and gender. Colin also discusses the societal impact of redefining gender, the role of AI in shaping public discourse, and the growing push to restore traditional values and truth in politics. The Karol Markowicz Show is part of the Clay Travis & Buck Sexton Podcast Network - new episodes debut every Wednesday & Friday. See omnystudio.com/listener for privacy information.

Five experts — Brendan Mahan, M.Ed., Shane Thrapp, Jesse J. Anderson, Kyrus Keenan "Ky" Westcott, and Marc Almodóvar — discuss ADHD in men, including struggles around expressing emotions, harboring self-doubt, contending with established expectations around masculinity, and more. ADHD Symptoms in Men: Additional Resources Free Download: 3 Defining Features of ADHD That Everyone Overlooks Read: For Men With ADHD — and Those Who Love Them Read: We Demand Attention on Sex Differences in ADHD Read: Face It — People with ADHD Are Wired Differently Access the video and slides for podcast episode #581 here: https://www.additudemag.com/webinar/adhd-symptoms-in-men-roundtable/ Thank you for listening to ADDitude's ADHD Experts podcast. Please consider subscribing to the magazine (additu.de/subscribe) to support our mission of providing ADHD education and support.

This episode is part 2 of Understanding sex differences in work and lifestyle. I share observations and insights based on data collected by evolutionary psychologist, Stephen Stewart-Williams. This research is important because it negates the big narrative that says women are behind men in prestige and financial gain because of biases and barriers against them.The data tells a different story.Part 2 is focused on how money is no longer a masculine contribution, how men have lost the fulfillment in meaning in work that used to be there, how important apprenticeships are for young men, and trying to understand what is work actually for and is the answer to that different for men and women?00:00 – 00:21 Trailer00:25 – 00:45 Introduction 00:45 – 04:19 Women vs Men Narrative 04:19 – 06:27: Why Fewer Female CEOs Exist 06:27 – 07:27 Screen Share: Life Values Data 07:27 – 09:00 Women's Primary Motivations Beyond Money 09:00 – 10:00 Why Work Feels Unnatural for Women 10:00 – 11:23 Societal Pressure vs Personal Values 11:23 – 12:20 Biological Influence on Preferences 12:20 – 14:17 Closing Reflections on Purpose and Work14:17 - 14:26 Outro___________________________If you found some value today then help me spread the word! Share this episode with a friend or leave a review. This helps the podcast grow.You can also watch the episodes on youtube hereFollow me on Instagram @anyashakhYou can book a discovery call at https://anyashakh.com/mentorship

Send us a textIn this episode of At the Bench, Betsy Crouch and David McCulley engage in a thought-provoking conversation with Dr. Eleanor Molloy, a neonatologist and physician scientist. They explore Eleanor's journey in neonatology, the importance of inflammation in neonatal health, and the challenges and rewards of conducting research in this field. The discussion also highlights the significance of collaboration, both within research teams and with parents, to enhance clinical practice and improve outcomes for neonates. Eleanor shares insights on the role of biomarkers, the impact of sex differences in research, and the necessity of international collaboration in pediatric research. The episode concludes with reflections on the balance between clinical work and research, the importance of community in academia, and the need for a rallying call to inspire the next generation of clinician scientists.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Cardiovascular Health Status and Long-Term Outcomes in a Primary Prevention Cohort.

In this episode I share observations and insights based on data collected by evolutionary psychologist, Stephen Stewart-Williams, on work preferences between men and women. This research is important because it negates the big narrative that says women are behind men in prestige and financial gain because of biases and barriers against them. The data tells a different story. It's much more to do with women's actual preferences versus what they say they want. Listen in to learn about what men and women value most when it comes to work, a simple way to think about a woman's hormone cycle, what makes work fulfilling, and much more.TIMESTAMPS:00:00 - 02:37 Men and women see work differently02:37 - 02:53 Stephen Stewart WIlliams02:54 - 03:24 Work with me one on one03:25 - 04:13 Men and women as complementary vs competitive04:13 - 05:58 Understanding gender roles and balance05:58 - 07:47 Key insights and reflections07:47 - 10:05 Evolution of modern work and purpose10:05 - 12:22 Redefining meaning in work and identity12:22 - 14:30 What makes work enjoyable14:30 - 16:36 Women's perspectives and real-life stories16:36 - 18:46 Picking up motivation and direction18:46 - 21:10 Cultural pressures and gender expectations21:10 - 23:40 How life and community have changed23:40 - 25:39 Final thoughts and reflections___________________________If you found some value today then help me spread the word! Share this episode with a friend or leave a review. This helps the podcast grow.You can also watch the episodes on youtube hereFollow me on Instagram @anyashakhYou can book a discovery call at https://anyashakh.com/mentorship

JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, introduces the October 21, 2025 issue of JACC, which is devoted entirely to Dr. Milton Packer's adipokine hypothesis.  Dr. Krumholz explains the rationale behind dedicating the issue to this bold conceptual framework, which proposes that dysfunctional visceral fat and its secreted adipokines drive HFpEF. We're also thrilled to present readers with 10 accompanying expert commentaries that explore, challenge, and contextualize the hypothesis.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI: A Meta-Analysis of Randomized Controlled Trials.

How we deal with stressful situations may be influenced by who we're with at the time. Alexei Morozov, research scientist with the Fralin Biomedical Research Institute at Virginia Tech University, looks into the social influence. Alexei Morozov, a research scientist with the Virginia Tech's Fralin Biomedical Research Institute at VTC. Sex Differences in how Mice […]

Almost didn't get this solo episode recorded. Been a rough week. But think I might get some relief after seeing a doctor here in Gdańsk. In this ep, I talk about a recent sauna experience—who I met there and why the interaction impacted me. One of them was a 19-year old from Ukraine. So I asked if she had any friends who'd been killed in the war. And what she told me is something I'll always remember. War is hell.

Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]

Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]

Dr. Mayer unpacks groundbreaking research on how men and women differ in their responses to stress, emotional stimuli, and gut sensations. Drawing from studies at UCLA's Oppenheimer Center, the conversation highlights key differences in brain-gut communication, revealing how neural pathways influence both emotional and physical health.You'll learn why women are more prone to conditions like IBS, how heart rate variability reflects emotional processing, and why men tend to show more action-oriented responses to stress. Dr. Mayer also explores the growing potential of personalized therapy—tailored to biological and psychological differences—to transform how we treat chronic gut-brain conditions.Key Topics Covered:• Sex-based differences in stress response patterns• Brainstem connectivity and gut sensitivity• Emotional awareness and heart rate variability• Chronic disease and the gut-brain connection• Personalized therapies based on genderUnderstanding these sex-based differences isn't just fascinating—it's essential for developing more effective, tailored approaches to brain-gut health. Tune in to explore how science is reshaping the way we treat mind and body together.Connect with Dr. Mayer:Website: ⁠⁠emeranmayer.com⁠⁠Instagram: ⁠@emeranmayer⁠Twitter/X: ⁠@EmeranMayerMD⁠YouTube: @EmeranMayerMD

You've been told your hormones make you irrational.That menopause means cognitive decline, your emotions are just chemistry gone wrong, and your brain is simply too complicated to understand.Science says otherwise.This week's guest, Dr. Sarah McKay, is a neuroscientist, author, and brain health expert who's spent her career dismantling the myths we've been told about women's brains. From the idea that we're slaves to our hormones to the fear that menopause means inevitable decline, Sarah brings data, nuance, and hope to conversations that have been shaped by outdated stereotypes for far too long.We explore:Why male and female brains are more similar than different, and how cultural context shapes the differences we do seeThe surprising truth about PMS: how rates vary from 12% in France to 90% in IranWhy the stereotype that women are "more emotional" isn't backed by scienceHow your brain actually changes during menopauseThe real relationship between hormones, sleep, and brain fogWhy early puberty affects girls and boys so differentlyWhat brain networks do when estrogen declinesThe truth about HRT and brain health: what the data actually showsHow expectations and cultural narratives create the experiences we haveSarah doesn't dismiss women's struggles or minimize real symptoms. Instead, she offers something more powerful: the understanding that our brains are not broken, fragile, or at the mercy of our biology. They're sophisticated, adaptive, and capable of remarkable reorganization throughout our lives.This isn't about toxic positivity or dismissing genuine challenges. It's about recognizing that the stories we've been told about women's brains, that we're irrational, unstable, or declining, aren't just wrong. They're actively shaping our reality.Love,Sarah Ann

This is a free preview of a paid episode. To hear more, visit www.thestudiesshowpod.comInspired by a new Nature paper on how the “maths gap” emerges between girls and boys in school, Tom and Stuart look into the evidence for psychological sex differences: in maths, in mental rotation, and, yes—in whether they like pink or blue.To listen to the full episode and read the show notes, you'll need to become a paid subscriber at www.thestudiesshowpod.com/subscribe.

Text Dr. Lenz any feedback or questions This episode dives into the complex relationship between migraines and hormonal changes, particularly focusing on estrogen. The discussion covers the prevalence of migraines, the distinction between migraines with and without aura, and the significant impact of reproductive hormones on migraine patterns, especially in women. Key topics include the discovery of the estrogen threshold, the influence of estrogen on neurotransmitter systems like serotonin and glutamate, and the potential of hormone-based treatments. The episode also examines the role of the trigeminal vascular system, calcitonin gene-related peptide (CGRP), and the impact of oral contraceptives on migraine frequency and intensity. Practical strategies for managing menstrual migraines and the importance of using headache diaries for accurate diagnosis are highlighted.00:00 Introduction to Migraines00:20 Types of Migraines and Auras00:42 Sex Differences in Migraine Prevalence00:59 Hormonal Influence on Migraines01:53 Estrogen's Role in Menstrual Migraines02:05 Historical Breakthroughs in Migraine Research02:35 Estrogen Threshold and Migraine Triggers04:10 Estrogen's Impact on Brain Function07:29 Neurotransmitters and Migraine Pathways11:15 Oxytocin and Migraine Prevention13:20 Trigeminal Vascular System and Migraines16:46 Calcitonin Gene-Related Peptide and Inflammation20:38 Oral Contraceptives and Migraine Management24:59 The Importance of Headache Diaries26:45 Conclusion and Future Research Click here for the Fibromyalgia 101 link.Click here to connect with Joy Lenz. Support the showWhen I started this podcast—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That's why I created this space: to offer education, validation, and hope. If you've been told fibromyalgia “isn't real” or that it's “all in your head,” know this—I see you. I believe you. You're not alone. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you'll find trusted, evidence-based insights here, drawn from my 28+ years as an MD. Please remember to talk with your doctor about your symptoms and care. This content doesn't replace personal medical advice.* ...

Who's to blame for the crisis of American masculinity? On the right, politicians tell men that they being oppressed by feminists and must reassert their manhood by supporting an authoritarian regime. And on the left, users of social media are often very irritating to people who write airport books.  Where to find us: Peter's newsletterPeter's other podcast, 5-4Mike's other podcast, Maintenance PhaseSources:Conscientiousness as a Predictor of the Gender Gap in Academic AchievementGender Differences in Scholastic Achievement: A Meta-AnalysisEarly Childhood Behavior Problems and the Gender Gap in Educational Attainment in the United StatesWhere The Boys Aren'tThe gender achievement gap in grades and standardised testsThe State of Gender Equality for U.S. AdolescentsHighlights of women's earnings in 2023The gender gap in educational outcomes in NorwaySocial Influences And The Gender Gap In Disruptive BehaviorFamily Disadvantage and the Gender GapWhat might interrupt men's suicide?As Women Take Over a Male-Dominated Field, the Pay DropsThe Cost of CaringIs Your Child Ready for Kindergarten?Age of Entry to Kindergarten and Children's Academic AchievementThe Effect of Age at School Entry on Reading Achievement Scores Beyond the Pros and Cons of RedshirtingSelf- Control and the Developing BrainImportance of Sex Differences in Impulse Control and AddictionsIt is a myth that boys lag behind in brain developmentThanks to Mindseye for our theme song!