Preprints in Motion

AI is the current hot topic, infiltrating every part of life. In this episode, we investigate AI podcasts. Can AI create a realistic sounding podcast about research papers? We fed GoogleLM two of our papers and asked it to create a podcast from them. What you're about to listen to is the unedited output from that, along with some of our own commentary. We'd love to hear what you thought! Did AI do a good job as a podcast? Would you listen to an entirely AI-driven podcast? Does this have a use case? Would you use it?Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website. Find a transcript for this episode on our website.If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production.Find us on social media: Jonny @JACoates.bsky.Social, Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira). The intro and outro music is Back to the Woods by Jason Shaw and is licensed under a Attribution 3.0 United States License. Sound effects used under the standard ZapSplat licence. Fill music is New Lands by Alex-Productions https://soundcloud.com/alexproductionsmusic. Creative Commons used under a CC BY 3.0 license.

In this episode, we explore the structural problems within academia, particularly the challenges faced by postdocs and the role of principal investigators (PIs). Our discussion highlights the power funders and university management have in shaping academic culture, the flaws in the tenure system, and the need for systemic change. We also emphasize the importance of fostering a better working environment for postdocs and senior staff, who often leave due to dissatisfaction with the current system.If this episode resonated with you or you're facing similar challenges, reach out — we'd love to hear your experiences.Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website. Find a transcript for this episode on our website.If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production.Find us on social media: Jonny @JACoates.bsky.Social, Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira). The intro and outro music is Back to the Woods by Jason Shaw and is licensed under a Attribution 3.0 United States License. Sound effects used under the standard ZapSplat licence. Fill music is New Lands by Alex-Productions https://soundcloud.com/alexproductionsmusic. Creative Commons used under a CC BY 3.0 license.

This week we discuss how E Coli adapt to starvation through changes to their proteomes with Théo Gervais, who is currently looking for a postdoc positions.  Read the full preprint -> https://www.biorxiv.org/content/10.1101/2024.02.29.582700v3 This episode was produced by Sonia Gomes Pereira and edited by Camila Valenzuela. Music by Dr John D Howard.Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production.Find us on social media: Jonny (@JACoates.bsky.Social), Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira). 

This week we discuss the costs associated with open science policies from a funders perspective with Dana Cobb-Lewis, a Program Officer at Aligning Science Across Parkinsons (ASAP).Read the full preprint -> https://www.biorxiv.org/content/10.1101/2024.12.09.627554v1.fullThis episode was produced by Sonia Gomes Pereira and edited by Sonia Gomes Pereira. Music by Dr John D Howard.Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production.Find us on social media: Jonny (@JACoates.bsky.Social), Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira). 

In this episode, we dive into the challenges of transitioning out of academia and navigating the often frustrating job market. From the realities of lower starting salaries to the impact of AI in recruitment, we discuss what makes job hunting so difficult—and what can be done to make it easier. We also explore how networking, persistence, and strategic career moves can help you land a fulfilling role outside academia.If this episode resonated with you or you're facing similar challenges, reach out—we'd love to hear your experiences.Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website. Find a transcript for this episode on our website.If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production.Find us on social media: Jonny @JACoates.bsky.Social, Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira). The intro and outro music is Back to the Woods by Jason Shaw and is licensed under a Attribution 3.0 United States License. Sound effects used under the standard ZapSplat licence. Fill music is New Lands by Alex-Productions https://soundcloud.com/alexproductionsmusic. Creative Commons used under a CC BY 3.0 license.

In this episode, we kick off a new chapter with the introduction of Walks with Jesse, a fresh and informal series recorded during daily walks. We discuss new features, the return of the main show, and the challenges and motivations behind the podcast's relaunch. Join us as we explore topics ranging from research integrity and academic culture to careers within and beyond academia. Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website. Find a transcript for this episode on our website. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production. Find us on social media: Jonny @JACoates.bsky.Social, Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira).  The intro and outro music is Back to the Woods by Jason Shaw and is licensed under a Attribution 3.0 United States License. Sound effects used under the standard ZapSplat licence. Fill music is New Lands by Alex-Productions https://soundcloud.com/alexproductionsmusic. Creative Commons used under a CC BY 3.0 license.

This week we discuss the increasing strain on scientific publishing with Mark Hanson, a Principle Investigator from the University of Exeter, UK. The number of scientific publications are rising at an alarming rate and disproportionately to the number of scientists. We talk about why this is happening and what some of the solutions might be. Read the full paper -> https://direct.mit.edu/qss/article/5/4/823/124269/The-strain-on-scientific-publishing  Explore the data yourself -> https://the-strain-on-scientific-publishing.github.io/website/  Mark's lab -> https://mahansonresearch.weebly.com/  Find Mark on Bluesky -> https://bsky.app/profile/hansonmark.bsky.social  Blog post mentioned by Mark -> https://mahansonresearch.weebly.com/blog/we-need-a-new-special-issue-lexicon This episode was produced by Jonny Coates and edited by Sonia Gomes Pereira. Music by Dr John D Howard. Submit your question that you'd like us to answer directly (https://www.speakpipe.com/preprints) or contact us via our website.  If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Instagram @Motion_Pod or visit our website; www.preprintsinmotion.wordpress.com. Preprints in Motion is a Rippling Ideas production. Find us on social media: Jonny @JACoates.bsky.Social, Camila (@Kamo_Valenzuela) & Sonia (www.linkedin.com/in/soniagomespereira). 

In this podcast episode, we shall discuss preprints and how they have impacted decisions in the past to award tenure/promotions to scientists from diverse geographies like the USA, Europe, India, and Africa. This is the second episode in the series, featuring Fiona Watt (EMBO).

In this podcast episode, we shall discuss preprints and how they have impacted decisions in the past to award tenure/promotions to scientists from diverse geographies like the USA, Europe, India, and Africa. The episode will feature senior scientists from these geographies, their experience being a part of the decision-making process in awarding tenure/promotion, the hardships, especially the ECRs face in those committees and how their preprints are viewed and assessed and the path forward for a just science environment that promotes open science.

Librarians have the potential to be great advocates for preprints at their institutions and beyond. In this episode, we'll speak with a librarian/librarians about how they champion preprints in their role/roles, the challenges they encounter, and how open science intersects with librarianship.

Episode 45 - Surviving freezing through leg amputation. But be careful about regeneration! This week we discussed how flies survive in freezing temperatures with Anne Sustar, a Research Scientist / Lab Manager, Dominic Golding, a medical student, and John Tuthill (@casa_tuthill), Associate professor at the University of Washington, Seattle. Read the full preprint -> Adult Drosophila legs do not regenerate after amputation https://www.biorxiv.org/content/10.1101/2022.10.25.513553v1 Article: Snow flies self-amputate freezing limbs to sustain behavior at sub-zero temperatures https://www.sciencedirect.com/science/article/pii/S0960982223012150?via%3Dihub This episode was produced by Sonia Gomes Pereira and Johny Coates and edited by Sonia Gomes Pereira.  If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Camila (@Kamo_Valenzuela) & Sonia (@SniaGPereira1). Generously supported by ASAPbio (https://asapbio.org | @asapbio_).  --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we celebrate the end of the year by chatting with our host Jonny Coates (@JACoates), Associate Director at ASAPBio. Join us for a conversation on the importance of all things preprints, science communication, open access, career development, and community building, plus his decision to leave academia and how this podcast started! If you stay until the end, you might have a glimpse of how it is to record an episode with pets.   Jonny Coates (https://jacoates.co.uk/) Preprints in Motion (https://preprintsinmotion.wordpress.com/) ASAPbio (https://asapbio.org) This episode was produced and edited by Camilla Valenzuela.   If you enjoyed this show, then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; https://preprintsinmotion.wordpress.com/.   Find us on Twitter: Jonny (@JACoates) & Camila (@Kamo_Valenzuela). Generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

It's open access week 2023 and to celebrate we focus on preprint peer review with Review Commons. We talk to Sara Monaco (@monaco_reviewcommons; Managing Editor) and Thomas Lemberger (@tlemberger; Deputy Head of Scientific Publications at EMBO and Project Leader for Review Commons). This episode was produced by Sónia Gomes Pereira and edited by Sónia Gomes Pereira.  If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Camila (@Kamo_Valenzuela) & Sonia (@SniaGPereira1). Generously supported by ASAPbio (https://asapbio.org | @asapbio_).  --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

To celebrate the end of Peer Review Week (2023) we recorded a live episode of the podcast with Stefano Bertozzi from Rapid Reviews to talk all things preprint peer review. No editing on this one! --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we discuss the academic career of a young PI with Charlotte Odendall @codendall, a Sir Henry Dale Fellow at King's College London. Join us for a conversation on starting a group with a Fellowship, how martial arts help with stress, and why we all need a friend who tells us “just do it”. Charlotte Odendall: https://www.kcl.ac.uk/research/odendall-group  This episode was hosted, produced, and edited by Dr. Camila Valenzuela. If you enjoyed this show, then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.   For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; https://preprintsinmotion.wordpress.com/.   Find us on Twitter: Jonny (@JACoates), Camila (@Kamo_Valenzuela) & Sonia (@SniaGPereira1) Generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

It's our 2 year birthday this month! To celebrate we take a trip back to the past and discuss the history of preprint servers with Matthew Cobb, a Professor at the University of Manchester.  Find Matthew's BBC podcast for more about the great science publishing scandal https://www.bbc.co.uk/programmes/m0004l7k If you want to learn more about the prehistory of preprint servers you can read the full article here https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003995 This episode was produced by Jonny Coates and edited by Camila Valenzuela.  If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Camila (@Kamo_Valenzuela) & Sonia (@SniaGPereira1). Generously supported by ASAPbio (https://asapbio.org | @asapbio_).  --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we discuss all things ECR with Mayank Chugh & Gracielle Higino, two current postdocs who are leading the efforts in fighting for a better environment for ECRs in academia.   Gracielle is an ASAPbio fellow and program co-ordinator at BIOS2, a community of researchers who are exploring and applying modern-day computational and quantitative techniques to address the challenges of biodiversity sciences. You can find her on Twitter @GracielleHigino and online https://www.graciellehigino.com/. Learn more about BIOS2 - https://bios2.usherbrooke.ca/.  Mayank is the President of the Harvard Medical Postdoc Association (HMPA). He also leads a DEIB working group in the department of systems biology towards fair recruitment of postdocs and faculty. He is an advocate for mental health awareness, equity, and a plethora of much needed changes in the current academic system - many listeners will already be familiar with his various writings and contributions to articles written by journalists. Mayank is also a poet and can be found on Twitter @mayank_mchugh and online https://www.mayankchugh.org/.  Implicit bias test https://implicit.harvard.edu/implicit/takeatest.html or learn more https://implicit.harvard.edu/implicit/user/jaxt/blogposts/piblogpost021.html This episode was produced by Jonny Coates and edited by Sónia Gomes Pereira.  If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Camila (@Kamo_Valenzuela) & Sonia (@SniaGPereira1). Generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we discuss the academic career of a young PI with Thibaut Brunet @thibaut_brunet, a G5 Group Leader at Institut Pasteur. Join us for a conversation on eating spiders, dancing creatures of the ocean, and the challenges of applying for and starting a group in the middle of the COVID-19 pandemic. Thibaut Brunet: https://research.pasteur.fr/en/team/evolutionary-cell-biology-and-evolution-of-morphogenesis/ This episode was produced and edited by Camilla Valenzuela. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee at https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; https://preprintsinmotion.wordpress.com/Find us on Twitter: Jonny (@JACoates) & Camila (@Kamo_Valenzuela). Generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we discuss hot and cold fibrosis with Shoval Miyara, a PhD student at the Weizmann Institute of Science.  Find shoval on Twitter (https://twitter.com/MiyaraShoval) Read the full preprint -> https://www.biorxiv.org/content/10.1101/2023.01.01.522422v1  This episode was produced by Jonny Coates and edited by Camila Valenzuela.  If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) & Camila (@Kamo_Valenzuela). Generously supported by ASAPbio (https://asapbio.org | @asapbio_).  --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

In the PI's seat - Nicolás Rascovan This week we discuss the academic career of a young PI with Nicolás Rascovan @NRascovan, a G5 Group Leader at Institut Pasteur. Nicolás Rascovan: https://research.pasteur.fr/en/team/microbial-paleogenomics/ https://nicorascovan.wordpress.com/ This episode was produced and edited by Camilla Valenzuela. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) & Camila (@Kamo_Valenzuela). Generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we discuss synthetic carbon fixation, running a lab as a postdoc and eLife's new publishing model with Sebastian Wenk, a Postdoc at the Max Planck Institute of Molecular Plant Physiology. Read the full preprint -> https://www.biorxiv.org/content/10.1101/2022.09.28.509898v1.full Sebastian -> https://www.mpimp-golm.mpg.de/person/50878/2132817 Arren Bar-Evan -> https://arren-bar-even.muchloved.com/ This episode was produced and edited by Jonny Coates. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8 & Camila (@Kamo_Valenzuela) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

This week we discuss the big changes occurring over at eLife with Editor in Chief Mike Eisen & original ECAG member Devang Mehta. From Jan 2023, eLife is focusing on public reviews and assessments of preprints and eliminating accept/reject decisions after peer review. Read more about this new model here: https://elifesciences.org/inside-elife/54d63486/elife-s-new-model-changing-the-way-you-share-your-research Mike Eisen: http://mcb.berkeley.edu/faculty/GEN/eisenm.html Devang Mehta: https://mehta-lab.com/ eLife: https://elifesciences.org/ This episode was produced by Jonny Coates and edited by Camilla Valenzuela. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) & Camila (@Kamo_Valenzuela). Generously supported by ASAPbio (https://asapbio.org | @asapbio_). --- Send in a voice message: https://podcasters.spotify.com/pod/show/preprints-in-motion/message

DISCLAIMER – These servers were reviewed from the approach of a first use instance and may not accurately reflect the full capabilities of each server. Moreover, any comments are opinions only. Preprint servers. There's an incredibly interesting history behind them (watch this space for more on that next year) but as of 2022 there are over 50 different preprint servers. No wonder it feels like they're an inescapable topic these days. I mean, we're contributing to that but hey. Some are highly specialised, such as EcoEvoRxiv (that's ecology, evolution and conservation), and some are geo-restricted, such as AfriaRxiv. Consideration of preprint servers based on discipline, scope, policies, and readership is relevant to inform where to deposit your preprint, and in turn to maximize visibility for the work and opportunities for feedback from researchers in your specific field. In this episode we take 3 of the top general bioscience preprint severs and put them to battle. We judge each on their: Appearance / ease of use – navigating and submitting Reach /size Journal integrations Additional offerings – public peer reviews, data, printing, links out, attention/metrics Positives of the server Negatives/improvement aspects of the server Why choose this server over the others? Useful links: https://asapbio.org/preprint-servers https://journals.biologists.com/bio/article/11/7/bio059310/276073/A-guide-to-preprinting-for-early-career Some preprint servers in addition to those discussed in the episode: OSF – more of a search engine but very useful bioRxiv/medRxiv Research Square Authorea F1000 Cell Sneak Peak and Preprints with the Lancet Preprints.org This episode was produced by Jonny Coates, Camilla Valenzuela and John Howard and edited by John Howard. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss RNA editing in cephalopods with postdoc Kavita Rangan. Read the full preprint -> https://www.biorxiv.org/content/10.1101/2022.09.25.509396v1.full This episode was produced by Jonny Coates and edited by Tala Noun & John Howard. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we chat with Daniela Saderi, she is the Co-Founder and Director of PREreview (@prereview_), an open project with the mission to bring more equity and transparency to the evaluation of research content, giving systematically excluded researchers better ways to find, train, and contribute to peer review. In her role, she is responsible for partnership and community building, fundraising, and supervising the development of open infrastructure and programs. Other links: https://info.africarxiv.org/ https://zenodo.org/record/6773615#.Yzn4alLMI-Q https://twitter.com/prereview_ https://elifesciences.org/labs/57d6b284/prereview-a-new-resource-for-the-collaborative-review-of-preprints https://onlinelibrary.wiley.com/doi/abs/10.1002/leap.1472 This episode was produced & edited by Jonny Coates. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod, Instagram @Motion_Pod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss modeling cell-cell collisions with Pedrom Zadeh, a 4th year PhD student at Johns Hopkins University. We learn how to distill basic biology into models and just how important and useful modeling can be as a tool. Read the full preprint -> https://www.biorxiv.org/content/10.1101/2022.05.13.491710v1.full Twitter thread on the preprint -> https://twitter.com/diffusiveblob/status/1526247248241246208?s=20&t=DGdP1wWJYW6wVsBFCeQp1w Other links: 3 blue 1 brown: https://www.youtube.com/c/3blue1brown Atomic Habbits: https://www.amazon.co.uk/Atomic-Habits-Proven-Build-Break/dp/B07J1XQSNK/ref=sr_1_1?adgrpid=130289978361&gclid=Cj0KCQjwj7CZBhDHARIsAPPWv3flGGVJehb4MWwgynAUZMCcrmn0OUt1J3RahhuXQ-y8HHwUb2ULqPMaArOKEALw_wcB&hvadid=542921826939&hvdev=c&hvlocphy=9050361&hvnetw=g&hvqmt=e&hvrand=1668537604868110719&hvtargid=kwd-1463848202564&hydadcr=24400_1816039&keywords=atomic+habits&qid=1663873098&s=books&sr=1-1 This episode was produced by Emma Wilson & Jonny Coates and edited by Camila Valenzuela. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss how cells can divide without nuclei and why this happens with Anand Bakshi, Fabio Echegaray Iturra (@fabioechegaray) & Mustafa G. Aydogan @AydoganLab. We also highlight Drosophila as an amazing model system that just keeps on giving and speak about the importance of preprints in collaboration and grant applications. We also discuss the limitations of preprints and the fluidity of science. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.06.15.496343v1.full Other links: https://www.theguardian.com/science/2017/oct/07/fruit-fly-fascination-nobel-prizes-genetics https://aydoganlab.com/ This episode was produced by Emma Wilson and edited by Jonny Coates. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss mitochondrial DNA and its importance in aging with Amy Vandiver (@AmyVandiver2). We also highlight a new method to quickly sequence full length mitochondrial DNA allowing for mitochondrial genome comparisons and the understanding of the diversity between mitochondrial DNA. As usual we also discuss the process of pre-printing, preLights and how they can generate collaborations. As well as understanding more about the MD PhD group leader route. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.23.480720v2.full This episode was produced by Emma Wilson and edited by Jonny Coates. Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.

This week we discuss a different take on sharing scientific findings with Alex Freeman (@alex_freeman), creator of Octopus @science_octopus. Octopus is resetting the incentive structure for research sharing, putting the emphasis on assessing the quality of what people are doing within the lab. Find out more here https://www.jisc.ac.uk/rd/projects/octopus-creating-a-new-primary-research-record-for-science Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction This episode was produced by Jonny Coates and edited by Camila Valenzuela. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss macrophage heterogeneity with Graham Heieis (@GrahamHeieis), a Post-doc at the Leiden University Medical Center (@LUMC_Leiden) in the Netherlands. We speak to him about mass cytometry and spectral flow cytometry and their use to investigate heterogeneity of tissue specific macrophages with regards to metabolism. We then have our usual chat about preprints, moving labs from Canada to Scotland as well as a bit of a a whiskey discussion. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.05.26.493548v1.full This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.

We've gone full circle!! Join us this week as we talk to Michele Avissar-Whiting (@maw_tweets), one of our first ever guests on this podcast and Editor in Chief of Research Square, as we discuss what happens to a preprint when the downstream publication gets retracted, how the papers can be linked to the preprint and if the preprint should be withdrawn. Michele talks to us about her recent paper which examines exactly this. Read the full article: https://doi.org/10.1371/journal.pone.0267971 Other links: https://scholarlykitchen.sspnet.org/2022/06/07/building-stronger-chains-together-keeping-preprints-connected-to-the-scholarly-record/ Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.

This week we discuss cilia length, ciliopathies and Chlamydomonas reinhardtii (also known as ‘Chlamy') with Brae Briggs (@BiggeBrae), a graduate student from at Dartmouth (@dartmouth),Geisel School of Medicine (@GeiselMed). We find out about a range of ciliopathies, the main composition of cilia as well as using ‘Chlamy' as a model to study cilia length. We also discuss the difficulties of moving in the middle of a PhD and pandemic, open science principles including preprints as well as how we try to have healthy work life balance. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.04.18.488674v1.full This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

We're 1 year old today! And to help celebrate our Birthday we have an extra long conversation with the incomparable Prachee Avasthi (@PracheeAC), Associate Professor at Dartmouth, President of ASAPbio and CSO & co-founder of Arcadia Science). We discuss everything from Prachee's career journey, role in promoting preprints and open science with ASAPbio and how she came to co-found Arcadia Science. Arcadia Science: https://www.arcadiascience.com/ Arcadia Science first open house: https://www.youtube.com/watch?v=_tS7CcutTmM Avasthi lab website: http://www.avasthilab.org/ ASAPbio website: https://asapbio.org/ eLife journal: https://elifesciences.org/ NewPI slack: https://newpislack.wordpress.com/ Setting up a lab guide: https://www.preprints.org/manuscript/202012.0147/v1 Read more about what we have achieved in our first year: https://preprintsinmotion.com/?p=913 This episode was produced by Emma Wilson & Jonny Coates and edited by John Howard & Jonny Coates. If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss heart dedifferentiation and regeneration with Avraham Shakked @abingtonSA a final year PhD student, at the Weizmann Institute of Science, @WeizmannScience. We speak about their ingenious mouse model which uses transient and temporarily controlled ERBB2 expression which allows dedifferentiation and redifferentiation of cardiomyocytes. Using this model they examined the difference in RNA, protein and heart function in the redifferentiated the cells with and without heart injury. We also speak about preprints, publishing and alternative careers for scientists. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.22.481415v1.full This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss placental inflammation and heart development with postdoc Eleanor Jayne Ward and PI Suchita Nadkarni (@SciSuchita) from Queen Mary, University of London. In this preprint, the authors show that during embryonic heart development, neutrophils (innate immune cells) can sometimes cause placental inflammation. This inflammation leads to a loss of barrier function. In turn, this allows maternal monocytes (innate immune cells that develop into macrophages) to migrate into the embryonic heart. These monocytes alter the tissue resident embryonic macrophages and damage cardiac tissue. This cardiac damage continues postnatally. We discuss this and how limiting placental inflammation was enough to promote normal cardiac development. We also talk about the precarity of postdocs and why making research/postdoc a recognised profession would be an important step forward. Read the full preprint on bioRxiv https://www.biorxiv.org/content/10.1101/2022.03.10.482611v1.full Visit the Nadkarni lab website https://www.qmul.ac.uk/whri/people/academic-staff/items/nadkarnisuchita.html Read more about the reasons scientists preprint https://www.biorxiv.org/content/10.1101/833400v1 This episode was hosted by Jonny Coates, produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit the subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss a population of stem cells called tanycytes which line hypothalamus in the brain with Alex Moore (@alexthemessiah) an Operational Research Analyst in the Civil Service & Kavitha Chinnaiya a Post Doc from the University of Sheffield (@sheffielduni). Tanycytes are population of cells which line the 3rd ventricle in the hypothalamus, self renew and give rise to neurons and glia within the brain. We speak to them about the key findings of their paper which includes expanding on their roles as stem cells, as well as further characterising them with a variety of markers including NrCAM. To do this they evoked a range of techniques including the use of spheroids and single cell RNA sequencing and we chatted to them about those. We also find out about working in the Civil Service and all the skills that PhD offers that helped with this move from academia. Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.12.15.472761v1.full This episode was hosted by Jonny Coats, produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

CW:// This week's episode touches on some themes revolving around caloric restriction which some listeners may find difficult. This week we speak to Ben Thomas @BenThomasSci, a final year PhD student at the University of Edinburgh @EdinburghUni about the benefits of caloric restriction, the impact in male and female mice as well as the effect of age. We highlight the ingrained sexisim within the biological sciences: often only male mice are used and we discuss how this can impact the results of various studies. In addition, we discuss the Edinburgh Open Research Initiative @edinburgh_open which promotes awareness and training of open research principles and lobby's for these to become formalized within the University of Edinburgh. We also discuss how incentives in science have led to a potentially flawed system and how his experience as a teacher has helped him in academic science. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.20.481222v1.full Other links: https://www.witworks.co.uk/ https://edopenresearch.com/ This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss how journalists approach using preprints with Alice Fleerackers (@FleerackersA), a PhD student at the Simon Fraser University (@SFU). She tells us how she went behind the scenes and to examine the decision making process of journalists on whether to use preprints or not, how they contextualized the science, and what practices they use to evaluate preprints. We discuss the benefits of preprints and highlight the importance of science communication and our role as scientists to prevent the spread of misinformation. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.03.479041v1.full This episode was produced by Emma Wilson and edited by Jonny Coates and John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss organoids and assembloids as models of neurodegenerative diseases with Sònia Sabaté Soler (@scisonias), a PhD student from the University of Luxembourg (@uni_lu). Find out about how 2D stem cells cultures are differentiated into complex 3D midbrain organoids which contain multiple cell types. We also discuss how microglia can be incorporated into the organoids to generate assembloids, mimicking the human brain more robustly. As always we speak about pre-printing and academic culture. We touch on some of the limitations on academia partially with reference to women in STEM and the potential of permanent post docs. . Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.01.21.477192v1.full This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on buy me a coffee https://www.buymeacoffee.com/preprints. Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

A really exciting special episode this week, as we talk to co-founders of BioRxiv (@biorxivpreprint) and MedRxiv (@medrxivpreprint) Richard Sever (@cshperspectives) & John Inglis (@JohnRInglis). We discuss how they met and started with BioRxiv along with the challenges they faced. We then chat about the considerations when accepting or rejecting preprints, or why certain papers are rejected from BioRxiv (they don't just accept everything). We also touch on the impact COVID 19 and the pandemic had on preprints as well as discuss the fraudulent papers and how they don't tend to be pre-printed. If you've ever been concerned about preprints this is a great episode to learn more about how preprint servers work and what the future may hold for BioRxiv from the key people in the field. Other links BioRxiv - https://www.biorxiv.org/ MedRxiv - https://www.medrxiv.org/ Company Biologist - https://www.biologists.com/ preLights - https://prelights.biologists.com/ Cold Spring Harbour Lab Press - https://www.cshlpress.com/ Vixra - https://vixra.org/ This episode was produced by Jonny Coates and Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss DNA recorders with Theresa Loveless (@TheresaLovele12), a Post Doc, at UC Irvine. DNA recorders can turn transient events into stable genomic ones and have been used to investigate cell fates and lineages. Join us as we find out more about how this is achieved and the incredible technology behind it!! We also chat about Theresa's experience of preprinting and academia, and how it can be improved!! Read the full preprint https://www.biorxiv.org/content/10.1101/2021.11.05.467507v1.full Whole-organism lineage tracing by combinatorial and cumulative genome editing: https://pubmed.ncbi.nlm.nih.gov/27229144/ molecular recordings by directed crispr spacer acquisition https://pubmed.ncbi.nlm.nih.gov/27284167/ Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts https://pubmed.ncbi.nlm.nih.gov/33479121/ Prime Editor: https://www.nature.com/articles/s41434-021-00263-9 This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss an amazing new technique developed by Dr Jakub Gemperle (@GemperleJakub), a Marie Curie Postdoctoral Research Fellow at the University of Manchester (@OfficialUoM). This technique uses 3 different inducible systems to allow on-demand control of endogenous genes, including being able to remove genes and then re-express them. A nice all in one package of techniques, great for rescue experiments!! We then also talk about Magnetogenetics where cells (and vesicles) can be moved around via magnets! As always we ask how this person found preprinting and we delve into the wonderful idea of permanent postdocs. Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.12.03.471086v1.full Other links https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001285 First Pig to Human heart transplant https://www.nature.com/articles/d41586-022-00111-9 This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

This week is our Christmas Episode! In this episode the Preprints in Motion team get together and discuss exciting, new preprints with a festive theme. We talk about smart soil, mitochondria DNA in relation to COVID 19, shock absorber stress granules as well as a discussion on nepotistic journals and much more including festive cheer and merriment. Merry Christmas and a Happy New Year from us at Preprints in Motion. Read the full preprints: https://www.biorxiv.org/content/10.1101/2021.11.19.468202v1 https://www.biorxiv.org/content/10.1101/2021.04.26.441141v1.full https://www.biorxiv.org/content/10.1101/2021.09.26.461876v1.full https://www.biorxiv.org/content/10.1101/2020.07.30.227553v1.full https://www.biorxiv.org/content/10.1101/348508v1.full https://www.biorxiv.org/content/10.1101/2021.02.03.429520v1?rss=1 https://www.biorxiv.org/content/10.1101/2020.02.07.938555v1.full This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss the exocyst with Dr Hannes Maib @hannes_maib a Post-Doctoral Researcher at the University of Dundee @dundeeuni!! He explains the complexities of the exocyst as well as the exciting biochemistry and binding assays used to understand its formation. In addition Hannes speaks candidly about starting working in a new lab as a Post-Doc, his views of hierarchical journal systems and how preprinting can help ECR take back ownership of their work in a great discussion with our host Dr Jonny Coats. Read the full preprint -> https://www.biorxiv.org/content/10.1101/2021.10.14.464363v1.full Other links -> LINK This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss prefigurative politics in academia with Stefano Davide Vianello, a PhD student at @EPFL_en in Switzerland. This is the idea that in order to change how a system works we should act in a way that reflects the change we want to see. In Stefano's case: preprinting to be the end goal and he has therefore submitted a preprint without any intention of submitting it to a journal. We speak to him about his reasons for this, why he is against academics paying for open access as well as 4 key points on what has to change to make academia more open for everyone, not just the global north. Read Stefano's preprint: https://www.biorxiv.org/content/10.1101/2020.06.07.138883v3 Read Stefano's opinion piece: https://commonplace.knowledgefutures.org/pub/vzn21ssv/release/2 This episode was produced by Jonny Coates and Emma Wilson, with editing by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss mice in space and the impact of prolonged space flight and how this can relate to austraunoughts with Jessica L Braun @jess_l_braun a PhD Student at the Brock University @BrockUniversity. Jessica speaks about her work looking at soleus and tibialis anterior muscles of mice which have spent 35-37 days on the international space station comparing Ca2+ uptake and SERCA function. We discuss everything from a mice mission control to cardigan rhythms and the different effects on males and female mice. We also talk about preprints and the increased attention it can bring as well as how to improve public engagement. Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.09.27.462048v1.full This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss Parkinson's Disease and single molecule spectroscopy with Dr Derrick Lau, a PostDoc at the University of New South Wales (@UNSW). Single molecular spectroscopy can be used to track the formation and purification of α-synuclein aggregates, a hallmark of PD, and potentially lead to a tool for early diagnosis of Parkinson's Disease. We discuss how single molecular spectroscopy is transferable to medium throughput and use bio fluids for early diagnosis of Parkinson Disease but also potentially other neurodegenerative diseases. Finally, we discuss preprints, what it it like to apply for PostDocs in a pandemic as well transitioning from immunology and neuroscience. Read the full preprint - https://www.biorxiv.org/content/10.1101/2021.08.09.455607v1.full Other links Microbiome in PD- https://www.nature.com/articles/s41531-021-00156-z Immunotherapy in PD - https://pubmed.ncbi.nlm.nih.gov/31978602/ α-synuclein in PD patients biofluides - https://pubmed.ncbi.nlm.nih.gov/32444560/ AttoBright - https://www.nature.com/articles/s41467-019-13617-0 https://www.nature.com/immersive/d41586-021-02563-x/index.html This episode was produced by Emma Wilson and edited by John D Howard . If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discussed the transfer of mitochondria from macrophages to cancer cells with Dr Chelsea Kidwill & Joseph Casalin, a Post-Doctoral Research Associate and PhD student at University of Utah (@UUtah) in the school of medicine. We delve into why this transfer occurs, the mechanism of transfer and how this impacts the recipient cells. We also speak to Joseph about his alternative schooling, in addition to our usual chat about the importance of preprints and our ideas for how to improve academia. Read the full preprint https://www.biorxiv.org/content/10.1101/2021.08.10.455713v1 This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss The Paywall Movie with Professor Jason Schmitt, chair of communication and Media at Clarkson University. We talk about academic publishing, the problems of the current system and more. In 2018, UK universities spent over £210 million on publication costs (access etc). This could have paid for; 700 ECR fellowships or 6500 postdocs or >8500 technicians or 3,500 PhDs (4yr fees + stipend). Meanwhile, Elsevier had profit margins of 37%. This week we discuss the broken publishing system and Jason's documentary - The Paywall Movie; the business of scholarship. Watch The Paywall Movie for free -> https://paywallthemovie.com/ Learn more about Plan S - https://www.coalition-s.org/ DORA - https://sfdora.org/ Picture a scientist - Netflix.com Retraction Watch - https://retractionwatch.com/ This episode was produced by Emma Wilson & Jonny Coates and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss how published nucleotide sequences are not always correct or to be trusted with Yasunori Park and Professor Jennifer A Byrne (@JAByrneSci), a research Assistant and PI at the University of Sydney (@Sydney_uni). We delve into the details of their nifty new text mining tool (Blast and Seek) which highlights papers with incorrect nucleotide sequences. We also discuss the most common mistakes found, the impact of these mistakes, and what we can do as researchers to prevent errors from occurring. We also talk about prepints and Australian Research Council's recent decision to ban preprints in their grant applications as well as some insight into our very own PhD's. Read the full preprint https://www.biorxiv.org/content/10.1101/2021.07.29.453321v1?fbclid=IwAR2LibD1DD8q6b5df3vMzgFXpmmA6q1E_UarbyaB0dq55fOaY8mmFvzbe14 Other links Open letter to ARC https://asapbio.org/arc This episode was produced by Emma Wilson and edited by John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss high throughput CRISPR/Cas9 screening and how these have been adapted to investigate novel treatments for COVID-19 with Emily Sherman a former Post Doc and Brian Emmer (@brianemmer), a new PI at University of Michigan (@UMIntMed) In this episode we cover details on how to conduct a high throughput CRISPR/Cas9 screen, the exciting advances in NextGen sequencing as well as what it's like to set up your own lab while working as a clinician during a pandemic. We also speak to Emily about her transition from academia to industry and our usual discussion about the benefits of preprints. Read the full preprint - https://www.biorxiv.org/content/10.1101/2021.06.10.447768v1.full Brian's lab homepage (https://emmer.lab.medicine.umich.edu/) https://www.nature.com/articles/nm1267 This episode was produced by Emma Wilson and edited by Jonny Coates and John D Howard. If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month! For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).