Podcasts about Pi

Forget the big team, big spend, big promises formula. Carlos Dominguez built a million-dollar PI firm in Miami—without a single employee or a dime on ads. How? By breaking every “rule” of modern law firm growth. This episode challenges what most lawyers think it takes to win. Carlos shares exactly how he turned cold starts and courtroom chops into $1.3M in settlements, why volume firms hand him their leftovers, and the overlooked tactics that are actually working in saturated markets.  What You'll Learn: The gritty early days of bootstrapping his solo firm in Miami How word-of-mouth and personal branding landed his first major wins Why he refuses to outsource intake—and what that means for referrals The 50-60 case ceiling every solo should watch for His vision for going from scrappy to specialized If you like what you hear - we do this every week. Learn how to build the personal injury law firm of your dreams - its easy.  Just hit subscribe.   PIMCON 2025 Tickets On Sale Now. Get yours today! Get Social! Personal Injury Mastermind (PIM) is on Instagram | YouTube | TikTok

We're approaching the 10-year anniversary of the dawn of our 30 five-stock samplers, picked from 2015 to 2021. In this special episode, David reflects on the fully updated results, sharing 10 fresh lessons from both the wins and the whiffs. How'd we do? Discover the highs and lows, the reversals in just a year's time… and the enduring principles of Rule Breaker Investing. Companies Discussed: AXON, IRBT, ISRG, LYV, MELI, NVDA, PAC, PEGA, PI, RMD, W, Z Host: David Gardner Producer: Bart Shannon Learn more about your ad choices. Visit megaphone.fm/adchoices

Flying adventures, peer pressure, a farewell to Michael Madsen, the new sport that is sweeping the nation, George C. Scott has a headache, a director I despise, a movie about a killer date, another solid horror movie from Osgood Perkins, the search continues, and closing the door. Stuff mentioned: Twelve Angry Men (1957), Kris Kristofferson "The Pilgrim - Chapter 33" (1971), Taxi Driver (1976), Reservoir Dogs (1992), Kill Me Again (1989), Caught Stealing (2025), Elvis (2022), Pi (1998), The Whale (2022), Drop (2025), The Monkey (2025), Longlegs (2024), Stephen King The Monkey (1980), and The Box (2009).

KEY TAKEAWAYS: - You need both digital and traditional marketing. Don't go 100% one or the other.- Every practice area is different. Your strategy should match your urgency level, location, and audience.- Each platform and tactic needs its own strategy — you can't copy-paste the same thing everywhere.- You're either spending time or money. There is no magical free version.DIGITAL MARKETING OPTIONS (Pick 3–4 max):- Influencer or affiliate shoutouts (great for PI with public clients)- SEO + Blogs (get found on Google with keyword-packed posts)- Ebooks/Checklists (guides like “10 things to know before your consult”)- Social Media (every platform needs its own strategy — don't post the same stuff everywhere) - LinkedIn = professional network - Instagram = visual storytelling - TikTok = casual, real-life law - YouTube = longform explainer content - Pinterest = great if you sell templates, contracts, or courses- Webinars (great for estate planning or info-heavy topics)- Google Ads (aka pay-per-click; expensive but fast leads)- Podcast (only if you're really interesting)- Guest on Podcasts (better option — share stories, not statutes)- Google/Yelp Reviews (ask for them + use keywords!)- Press Releases (only if you have big news to share)- Write for online legal sites (Above the Law, Law360, etc.)TRADITIONAL MARKETING OPTIONS (Layer these in):- Cold calling referral sources (real estate agents, chiropractors, etc.)- Flyers + brochures (leave them in local spots)- Speaking engagements (CLE panels, bar events — build authority)- Direct mailers (expensive, but people *do* keep them)- Print ads in local magazines (great for estate or biz lawyers)- 1:1 Lunches (Nermin's fave — ditch the networking groups)- Bar/professional associations (one intro could lead to big biz)- TV + radio ads (super expensive; only works with a real strategy)- Referral + networking groups (BNI, Lawyers 500, etc.)- Past client check-ins (call your old clients. Seriously.)- Promo products (pens, mugs — layered in, not random)- Billboards (yes, they still work — include your phone number!)- Firm-branded magazine (expensive, but unforgettable)FINAL REMINDERS:- You can't just "do marketing." You need to pick a few things and do them well.- Each channel needs its own plan — don't treat them all the same.- Feeling overwhelmed? That's normal. Marketing is a full-time job.- If you're not spending money, you'll need to spend time. - If you're doing neither — you're not marketing.

What does the 'rule of law' really mean in China? How does it shape the country's politics, both at home and on the world stage? And why should it matter to the rest of us when universal norms are being challenged? Dr. Tabita Rosendal from the Centre for East and South-East Asian Studies at Lund University, talks to Dr. Martin Lavicka, a scholar of Chinese studies, about his latest project on the rule of law in the Chinese context. Dr. Martin Lavicka is a visiting research fellow at the Department of History and the Centre of East and South-East Asian Studies, Lund University. Martin is the PI of the project CLAW: Chinese Conceptualisation of the Rule of Law: Challenges for the International Legal Order. Martin's research has been supported by the OP JAC Project “MSCA Fellowships at Palacký University II.” CZ.02.01.01/00/22_010/0006945 at Palacký University Olomouc, Czech Republic. Episode producer: Julia Olsson Links: ResearchGate profile AcademiaEdu profile Martin's latest article “Rule of Law with Chinese Characteristics: A Contested Landscape” The Nordic Asia Podcast is a collaboration sharing expertise on Asia across the Nordic region, brought to you by the following academic partners: Asia Centre, University of Tartu (Estonia) Asian studies, University of Helsinki (Finland) Centre for Asian Studies, Vytautas Magnus University (Lithuania) Centre for East and South-East Asian Studies, Lund University (Sweden) Centre for East Asian Studies, University of Turku (Finland) Norwegian Network for Asian Studies This podcast was recorded in May 2025 in the wonderful podcast studio at Altitude, Collab Arena in The Loop. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/political-science

Send us a textLet's get into the latest episode of The Real Housewives of Miami! Check out the visual on YouTube. From Julia STILL making excuses for her animal behavior while Martina cosigns to the baby shower becoming about Lisa to Kiki still fighting for a mimosa glass; (now she's talking??) This episode was something else. I also get into Dr. Nicole's interview where she talks one of her cast mates allegedly hiring a PI to investigate her and Anthony.  Let's get into it all!Support the show

The Harvard-Yale game brings us by vector analysis to rearrive upon the scraggly isthmus of Long Island. The tales of Vibes are much rehearsed, wooing Kit between Dittany eyelashes and forms seen lonesome in the hallways. The fall of an earnest worker marks the end of Fleet's refrain, but lines up well to the west with Lew on a quest. What clashes here, in mines and minds? Kieselguhr soaked in nitro, wrapped in newsprint and 'cyclomite'! But White City's loss is our gain, as the suspect PI bolts, chased by beavers in the brain, and our scholars, nonplussed, watch his newfound escapades.If you like what we're doing and want to support the show, please consider making a donation on Ko-Fi. Funds we receive will be used to upgrade equipment, pay hosting fees, and help make the show better.https://ko-fi.com/mappingthezoneAs always, thanks so much for listening!Email: ⁠mappingthezonepod@gmail.com⁠Bluesky: https://bsky.app/profile/mappingthezone.bsky.socialTwitter: https://twitter.com/pynchonpodInstagram: https://www.instagram.com/mappingthezonepodcast/Show art by Brad Wetzel: @bradspersecond (on IG and Reddit)bradspersecond.com

Na Novi Zelandiji je pristal z zadnjim letalom pred zaprtjem države zaradi koronavirusa. Morda ne čisto zadnjim, vsekakor pa je bil njegov let med zadnjimi. Ko so bili še v zraku, so namreč uradno omejili vstop v državo. Urh Vodopivec je bil na tistem letu pred petimi leti eden redkih tujcev. Večinoma so se namreč domačini vračali domov. Po neobičajni proceduralni dobrodošlici si je sčasoma našel delo kot obiralec kivijev. Pozneje si je še nekajkrat podaljšal bivanje, se zaposlil v izposojevalnici avtomobilov, zdaj pa je tik pred tem, da pridobi stalno prebivališče in tudi s tem povezane pravice. Domov se mu še ne mudi.Poznate potencialnega sogovornika ali sogovornico za epizodo Globalne vasi? Pišite na nejc.jemec@rtvslo.si

Piälguöp ku piäl nhom ee töŋ kawënye raan wïc ku ŋic lɔn rɛ̈ɛ̈l yen nyiɛ̈nde.

Are you constantly being asked to do more than your role requires because others around you aren't stepping up? You might be getting pulled into a leadership vacuum. In this final episode of the Leadership Series, I define what a leadership vacuum is and explain why so many mid-career academics—especially those in middle-management roles—get pulled into these gaps. Whether you're a department chair, PI, or program director, it's easy to start taking on responsibilities that aren't technically yours, particularly when leadership above you is weak or absent. I share how to recognize the vacuum, why scholars are especially vulnerable to it, and, most importantly, how to set boundaries that preserve your energy, time, and mission-driven focus. If you've ever felt overextended in your academic role, this episode is for you. Learn how to define your position and hold your boundaries with clarity and confidence. For full show notes visit scholarsvoice.org/podcast. We've opened the waitlist for our next cohort of Navigate: Your Writing Roadmap®. Check out the program details and get on the waitlist here.   CONTINUE THE CONVERSATION: Our 12-week Navigate: Your Writing Roadmap® program helps tenure-track womxn and nonbinary professors to publish their backlog of papers so that their voice can have the impact they know is possible. Get on the waitlist here! Cathy's book, Making Time to Write: How to Resist the Patriarchy and Take Control of Your Academic Career Through Writing is available in print! Learn how to build your career around your writing practice while shattering the myths of writing every day, accountability, and motivation, doing mindset work that's going to reshape your writing,and changing academic culture one womxn and nonbinary professor at a time. Get your print copy today or order it for a friend here! If you would like to hear more from Cathy for free, please subscribe to the weekly newsletter, In the Pipeline, at scholarsvoice.org. It's a newsletter that she personally writes that goes out once a week with writing and publication tips, strategies, inspiration, book reviews and more.   CONNECT WITH ME:  LinkedIn Facebook YouTube

“In a world where division seems to be the norm, we stand united. We are musicians, singers, artists, and advocates, all bound by the belief that music can bridge the gaps and mend the divides. Our mission is simple yet profound: to bring people together, to celebrate our shared humanity, and to recommit to the promise of a "more perfect union."Meet the co-founders Gary Aamodt and Celia Ellingson, Together In Hope Project, a Minneapolis-based nonprofit organization, who serve as the driving force behind Sing Democracy 250 - and in this conversation you get to know them!Learn more about Gary and Celia:  https://www.singdemocracy250.org/leadership-teamExplore and sign up for the Sing Democracy 250 Project - it's free! -  www.singdemocracy250.orgThis episode is brought o you by our friends at Perform International - ask ChatGPT why we should take our musicians on tour, what will it say? PI can help :) Perform-International.com

Did you like the episode? Send me a text and let me know!!Mastering AI Search Optimization for Entrepreneurs | Business Conversations with PiIn this episode of Business Conversations with Pi, hosted by Skoob along with virtual co-host Pi and AI assistant, the discussion revolves around essential strategies for optimizing business content to be easily found in AI-powered searches. The episode covers key tips such as using natural language, focusing on user intent, employing long-tail keywords, and optimizing for voice searches and featured snippets. Additional strategies include enhancing meta descriptions, structuring URLs, leveraging internal linking, and focusing on user experience. The hosts also highlight the importance of podcasts and YouTube videos in improving search visibility and provide suggestions for useful SEO books. Tune in to gain actionable insights and turn your startup dreams into reality."SEO For Dummies" by Bruce Clay: "The Art of SEO" by Eric Enge"SEO 2025" by Adam Clarke: "Content Marketing Secrets" by Marc Guberti:00:00 Introduction to Business Conversations with Pi01:51 Optimizing Content for AI Searches03:00 Tools for Identifying Long-Tail Keywords04:06 Additional Strategies for AI Search Optimization05:06 Leveraging Podcasts and YouTube for Visibility05:59 Optimizing YouTube Shorts for AI Searches06:55 Recommended Books for SEO and AI Search Optimization08:01 Final Thoughts and Encouragement Thank you for being a Skoobeliever!! If you have questions about the show or you want to be a guest please contact me at one of these social mediasTwitter......... ..@djskoob2021 Facebook.........Facebook.com/skoobamiInstagram..... instagram.com/uepodcast2021tiktok....... @djskoob2021Email............... Uepodcast2021@gmail.com Skoob at Gettin' Basted Facebook PageAcross The Start Line Facebook Community If you would like to be coached on your entrepreneurial adventure please email me at for a 2 hour free discovery call! This is a $700 free gift to my Skoobelievers!! Contact me Now!! On Twitter @doittodaycoachdoingittodaycoaching@gmailcom

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There's a big difference between watching a leadership tool in action—and experiencing it with your own team, focused on your real business challenges. That's the power of our People Strategy Power Hour.  At A Leadership Beyond, we believe people-first doesn't mean soft—it means strategic. When leaders understand their own leadership DNA and how their team naturally works together, they can move faster, solve business problems more effectively, and stay aligned to what matters most. In this week's podcast episode, we walk through a live demo of the Predictive Index platform—one of the ways we leverage people data to gain insight into concrete business strategy. You'll see: How one leader's PI profile reveals her strengths and stretch points What happens when her drives meet those of her team—and where friction or flow occurs How the PI Team Map and Strategy Alignment tools spotlight blind spots and untapped potential A real-time example of flexing styles to meet strategic goals These insights don't just create understanding—they open up the kinds of conversations that lead to better execution, stronger collaboration, and lasting alignment. Want to see it through your own lens? Schedule your People Strategy Power Hour here: https://aleadershipbeyond.com/people-strategy-power-hour-2/ You will receive a complimentary 6-minute PI assessment and a 30-minute 1:1 debrief with us followed by a team assessment and debrief if you choose to continue. You'll walk away with: A deeper understanding of your leadership style Insights into how to work better with your team The ability to identify and address gaps between your business objectives and your team's strengths A practical view of where work style misalignments may be holding your team back—and how to flex toward alignment A real-time glimpse into how this tool supports your business goals  A Leadership Beyond exists to support the alignment between the business strategy and people strategy - to drive results with people not at the expense of people (Talent Optimization). Subscribe to our podcast to join the Leadership Beyond Community of Conversation and hear insights from thought leaders and human development experts leading the way in the field of Talent Optimization. We are grateful to you and always eager to hear from you! To learn more visit https://aleadershipbeyond.com Tom & Adrienne 

Można Pięknie Żyć *---Witaj! "Można Pięknie Żyć*" to seria podcastów, w której odkrywamy, jak zmiany w stylu życia mogą poprawić nasze zdrowie metaboliczne. Skupiamy się na Terapeutycznym Ograniczaniu Węglowodanów i jego pozytywnym wpływie na metabolizm oraz ogólne samopoczucie. Pamiętaj, że zdrowie zaczyna się od wiedzy, a my jesteśmy tu, aby dostarczać Ci inspirację i praktyczne wskazówki na drodze do pięknego życia. ZaczynamyDlaczego nie możesz przestać jeść słodyczy? To nie brak silnej woli – to biochemia Twojego mózgu!

Glowing orbs light the way to a sleepy conference room corner as our PI friend does some cloud based computing and picture deduction.Heads up, this series is set in the Big Farm. It's still pretty sleepy but feel free to skip if that's not your cup of tea.Start a 7 day FREE trial of Sleep With Me Plus- The ultimate way to listen to show, based on how YOU listen! Get your Sleep With Me SleepPhones. Use "sleepwithme" for $5 off!!Are you looking for Story Only versions or two more nights of Sleep With Me a week? Then check out Bedtime Stories from Sleep With MeShow Artwork by Emily TatHELIX SLEEP - Take the 2-minute sleep quiz and they'll match you to a customized mattress that'll give you the best sleep of your life. Visit helixsleep.com/sleep and get a special deal exclusive for SWM listeners!ZOCDOC - With Zocdoc, you can search for local doctors who take your insurance, read verified patient reviews and book an appointment, in-person or video chat. Download the Zocdoc app to sign-up for FREE at zocdoc.com/sleep PROGRESSIVE - With the Name Your Price tool, you tell Progressive how much you want to pay for car insurance, and they'll show you coverage options that fit your budget. Get your quote today at progressive.comQUINCE - Quince sells luxurious, ethically-made clothes and bedding at an affordable price. Transition your bed for the season with soft, breathable bedding from Quince. Go to Quince.com/sleep to get free shipping and 365-day returns on your next order. MINT MOBILE - This year, skip breaking a sweat AND breaking the bank. Get your summersavings and shop premium wireless plans at mintmobile.com/sleepwithme (Upfront payment of $45 for 3-month 5 gigabyte plan required [equivalentto $15/mo.]. New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See Mint Mobile for details.) Learn about your ad choices: dovetail.prx.org/ad-choices

Romesh Ranganathan is a comedian and BAFTA-winning broadcaster who has been a fixture on British television screens for the past decade. In addition to his TV shows and stand-up tours he presents the Weakest Link on BBC One, Radio Two's Saturday morning show and another weekly Radio Two programme in which he shares his passion for hip hop music. Romesh was born in Crawley in West Sussex where he still lives. His parents came to the UK from Sri Lanka in 1975. His father Ranga was an accountant who spent time in prison for fraud during Romesh's teenage years. At that point Romesh and his brother were brought up by their mother Sivashanthini – known as Shanthi – who has appeared alongside Romesh on several of his television programmes.In 2001 Romesh became a maths teacher at the school where he'd previously been a pupil. A few years later he started taking part in open mic evenings where he developed his skills as a stand-up. In 2011 he quit his teaching job to pursue a career in comedy. He has spoken candidly about his own mental health and in 2023 he became a patron of the charity CALM (Campaign Against Living Miserably). Romesh lives in Crawley with his wife Leesa and their three sons.DISC ONE: Lose Yourself - Eminem DISC TWO: Let's Hear it for the Boy - Deniece Williams DISC THREE: The Power of Love - Huey Lewis & The News DISC FOUR: Through the Wire - Kanye West DISC FIVE: Broken Clocks - SZA DISC SIX: Back at One - Brian McKnight DISC SEVEN: I Wish - Stevie Wonder DISC EIGHT: Bring the Noise - Public Enemy BOOK CHOICE: Life of Pi by Yann Martel LUXURY ITEM: An unlimited supply of aubergine curry CASTAWAY'S FAVOURITE: Back at One - Brian McKnight If you are suffering distress or despair and need support, including urgent support, a list of organisations that can help is available at bbc.co.uk/actionline.Presenter Lauren Laverne Producer Paula McGinley

Można Pięknie Żyć *---Witaj! "Można Pięknie Żyć*" to seria podcastów, w której odkrywamy, jak zmiany w stylu życia mogą poprawić nasze zdrowie metaboliczne. Skupiamy się na Terapeutycznym Ograniczaniu Węglowodanów i jego pozytywnym wpływie na metabolizm oraz ogólne samopoczucie. Pamiętaj, że zdrowie zaczyna się od wiedzy, a my jesteśmy tu, aby dostarczać Ci inspirację i praktyczne wskazówki na drodze do pięknego życia. ZaczynamyW tym odcinku podcastu dowiesz się, które produkty – choć często uchodzą za zdrowe – mogą poważnie osłabiać Twoją tarczycę, zaburzać gospodarkę hormonalną i odbierać energię. Wyjaśniamy, dlaczego coraz więcej osób, także dzieci i mężczyzn, zmaga się z niedoczynnością tarczycy i Hashimoto, i jak ogromny wpływ na ten trend ma codzienna dieta. Odkryjesz: ·       Jakie 5 produktów najczęściej wywołuje mgłę mózgową, zaburzenia nastroju i przewlekłe zmęczenie. ·       Jak gluten, cukier, soja, rafinowane oleje roślinne i dodatki chemiczne mogą wywoływać stany zapalne i autoimmunologiczne ataki na tarczycę. ·       Dlaczego nie wystarczy „brać tabletki” i jak świadome wybory żywieniowe mogą realnie poprawić Twoje samopoczucie. ·       Jak czytać składy produktów, na co zwracać uwagę i co warto mieć w kuchni, by wspierać zdrowie tarczycy. ·       Czy naprawdę musisz suplementować jod i dla kogo taka suplementacja może być szkodliwa.To solidna dawka praktycznej wiedzy i prostych wskazówek, które pomogą Ci odzyskać energię, poprawić nastrój i zadbać o zdrowie hormonalne. Posłuchaj i przekonaj się, jak niewielkie zmiany mogą zrobić wielką różnicę – Twoja tarczyca Ci podziękuje!

It's time for another Pop Off episode - the ultimate music showdown - and this time we're diving into the latest BLACKPINK solo era. Chris and Chantel Nicole break down the lead singles from each member's most recent solo projects, covering the songs, music videos, and performances in brutal detail. Who will rise to the top and take the solo crown? Viewer discretion is advised, your fave will be criticized...Contestants:ROSÉ - "toxic till the end"JISOO - "earthquake"LISA - "FXCK UP THE WORLD"JENNIE - "like JENNIE"Join us on Patreon!: https://www.patreon.com/CCTVPOPSFollow us on social media: https://linktr.ee/cctvpops0:00 - Intro1:50 - Round 1: Song26:08 - Round 2: Music Video42:48 - Round 3: Performance/Choreography1:05:24 - Overall WinnerReferences:ROSÉ - “toxic till the end” MV https://www.youtube.com/watch?v=eA0lHNZ1KCAJISOO - “earthquake” MV https://youtu.be/2V6lvCUPT8I?si=rzQ0BattFRFMbUxuLISA - “FUTW (Vixi Solo Version)” MV https://youtu.be/r5VRqWkFpEQ?si=A4-fz7b9c9CcjU9-JENNIE - “like JENNIE” MV https://youtu.be/JSFG-IE8n_c?si=vUQaYgNcajgjTVNU ROSÉ - “toxic till the end” Live at Gala des Pièces Jaunes https://www.youtube.com/watch?v=BEmKyWBx1O4JISOO - “earthquake” Performance Video https://youtu.be/Z33suvklkx0?si=01btvy6pvEb-pZnLISA - “FUTW” YouTube Music Nights Special Performance https://youtu.be/gwRqLbWqKlM?si=XVyPG6SPXDXe3cUiJENNIE - “like JENNIE” Performance Video https://youtu.be/XD00TJ-6WSw?si=Drgb9k0zpHiPexVPChris and Chantel dancing with ILOVEDANCE [KPOP IN PUBLIC NYC] LIKE JENNIE | JENNIE (제니) DANCE COVER BY I LOVE DANCE https://youtu.be/Nt3EjaQFNic?si=gvA5Bzv7hgF1Mfxk

1-Striscia di Gaza. La fame è usata come arma di guerra. Il giornale Haaretz dà la parola ai soldati israeliani. Le testimonianze raccolte confermano le denunce delle Ong. ( Martina Stefanoni) 2-Nucleare iraniano: Donald Trump gioca la carta degli incentivi per rilanciare i negoziati. ( Nima Bahlevi, Alfredo Somoza) 3-Gran Bretagna. Più welfare meno armi. Il premier Starmer fa marcia indietro sui tagli ai sussidi dopo la rivolta dei deputati laburisti. ( Daniele Fisichella) 4-Allarme disuguaglianza. Negli ultimi dieci anni la ricchezza dell'1% più ricco è aumentata di circa 34 mila dollari. Il rapporto Oxfam alla vigilia della Conferenza sul finanziamento dello sviluppo di Siviglia. ( Giulio Maria Piantadosi) 5-Cervelli in fuga dall'oscurantismo. Marsiglia ha accolto ieri primi ricercatori americani. ( Francesco Giorgini) 6-Massive Attack. Concerti oltre i confini della musica. La recensione di Pier Giorgio Pardo.

PiroPukis, Ajedrez kaffir, Eventos Disney, Midnight Hammer, Los Injertos, PeloMesias, Cabala Cuantica, Piñas Swingers, Autobuses Chotas, Jurassic Vlad, Voyeur App y mucho más ENLACES Piñas Swingers https://www.dailystar.co.uk/news/weird-news/people-just-realising-pineapples-hidden-35439925 Maniquí Ceo https://www.google.com/amp/s/www.elconfidencialdigital.com/articulo/politica/pablo-casado-incorpora-como-consejero-nueva-empresa-financiera/20250624130000969852.amp.html Trosko chencheo https://www.google.com/amp/s/www.eldiario.es/politica/miguel-urban-denuncia-audiencia-nacional-montaje-policial-falso-trafico-cocaina_1_12415204.amp.html Navegantes ilustres https://www.20minutos.es/noticia/5725978/0/michelle-obama-steven-spielberg-navegan-juntos-las-aguas-mallorca-yate-cineasta/ Cabala Cuantica https://www.youtube.com/watch?v=Jzzrj8m8ntE vK-Beauty https://www.koreaherald.com/article/10519105 HunSen Cabreado https://www.arabnews.com/node/2606016/world Furry Friends https://www.thestar.com.my/aseanplus/aseanplus-news/2025/06/24/furry-friends-become-celebrities-malaysian-cats-are-now-television-fashion-icons Eventos Disney https://www.diariovasco.com/sociedad/disneyland-paris-boda-nina-9-anos-20250623092301-nt.html YahooZim Boys https://iharare.com/three-zimbabweans-arrested-in-india-for-us127k-cyber-fraud-involving-kola-nut/ Bomba moderada https://www.prensa-latina.cu/2025/06/22/explosion-terrorista-contra-una-iglesia-en-capital-siria/ Vompeti Balconing https://www.larazon.es/baleares/competicion-muertos-balconing-baleares-indigna-reino-unido_20250617685182d7f68fe227a8418d7b.html Estampida escolar https://allafrica.com/stories/202506270083.html. Ataque aéreo https://allafrica.com/stories/202506270206.html Ola de Ejecuciones https://nyheder.tv2.dk/live/udland/2025-01-13-seneste-nyt-om-krig-i-mellemoesten BatiChinos https://www.thestar.com.my/aseanplus/aseanplus-news/2025/06/25/viruses-related-to-deadly-human-diseases-found-in-chinese-bats Kalma https://www.koreaherald.com/article/10518057 PeloMesias https://ensegundos.com.pa/2025/06/24/trump-merece-el-premio-nobel-de-la-paz-segun-israel/ Alligator Alcatraz https://www.eleconomista.es/actualidad/noticias/13437144/06/25/asi-es-alligator-alcatraz-la-nueva-carcel-rodeada-de-caimanes-que-ha-abierto-trump-en-florida.html Aviones Nucleares https://www.infobae.com/wapo/2025/06/27/reino-unido-incorporara-aviones-con-armamento-nuclear-en-un-plan-militar-que-busca-contener-la-amenaza-rusa-en-europa/ Agente n30 https://www.dailystar.co.uk/news/latest-news/new-mi6-chiefs-grandad-leading-35461746 Ketademia https://www.arabnews.com/node/2606008/world Curry Picante 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https://indianexpress.com/article/cities/lucknow/etawah-tonsuring-incident-fir-filed-against-2-kathavachaks-protesters-clash-with-police-attack-vehicles-10091295/ Aviones Defectuosos https://www.dawn.com/news/1919782/india-aviation-regulator-says-multiple-defects-reappearing-on-aircraft Venta de burras https://www.enlacejudio.com/2025/06/27/israel-revela-la-dramatica-informacion-que-condujo-a-la-operacion-leon-ascendente/ Midnight Hammer https://esrt.space/actualidad/555649-ataque-instalaciones-nucleares-iran-no-exito JeringaFest https://www.elcomercio.com/actualidad/mundo/festival-musica-francia-termina-con-145-personas-pinchadas-jeringas/ Post Jeringa Fest https://www.vozpopuli.com/internacional/las-calles-de-paris-se-llenan-de-violencia-370-detenciones-1500-heridos-palizas-y-robos-en-una-noche.html Mertz con el Pueblo https://www.franceinfo.fr/monde/conflit-israel-iran/israel-fait-le-sale-boulot-pour-nous-tous-en-iran-polemique-en-allemagne-apres-les-propos-du-chancelier-friedrich-merz_7324038.html Afgano Abatido https://www.dawn.com/news/1920437/german-police-kill-afghan-after-officer-stabbed Rutte Peloto https://www.dawn.com/news/1919863/flatterer-in-chief-how-natos-rutte-worked-to-win-over-trump Cumbre Paralela https://elpais.com/internacional/2025-06-25/paseo-por-un-museo-y-un-rio-con-briggite-macron-pero-sin-melania-trump-la-cumbre-paralela-de-las-parejas-de-los-lideres-de-la-otan.html Meloni vs VonderLaca https://euractiv.es/section/politics/news/exclusive-melonis-eu-allies-split-on-bid-to-bring-down-von-der-leyen/ BodyCam Medici https://www.ilgiorno.it/cronaca/ospedali-bodycam-medici-infermieri-pronto-soccorso-iwaejswn Enseña Porongas https://es.euronews.com/my-europe/2025/06/26/el-lider-armenio-amenaza-con-ensenar-su-pene-al-portavoz-de-la-iglesia-ortodoxa-para-proba Crisis Inmobilaria 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Isabella Braveheart photo by Dauss Miller Isabella Braveheart is an evolutionary performance artist and activist, speaker, playwright, director and producer who transmutes the pains of humanity into the voice of truth through bold multimedia transmissions and heart-centered, experiential events in service of bringing our global family back to wholeness and love. She has been called a Deep Water Heart Surgeon and an Urban Priestess and she calls herself a heart-trepreneur. Don't miss her spoken word performance of "Patriot" and her thoughts on how we might reclaim this fraught term while prioritizing personal, then societal healing. To start off the show, co-hosts Wendy Sheridan and Robin Renée chat in Timeline Cleanse about an unusual item on display at the Rijksmuseum in Amsterdam and the recent Sky Farm Arts & Music Festival in Basking Ridge, NJ. Robin and Wendy recount their No Kings Day experiences in Pièce de Résistance and discuss some activists' tendency toward protest gatekeeping. Wendy shares another brief and important principle from On Tyrrany. Things to do: Learn more about Ithe work of Isabella Braveheart on her website and keep up with her on Instagram and Facebook. Find out more about SPREAD, an evocative evening for the distinguished palate. Read On Tyrrany: Twenty Lessons From the Twentieth Century by Timothy D. Snyder. After No Kings Day, stay politically active! Check out Sky Farm. Listen to Robin Renée on Spotify. Listen to the Saved By Zero show by Robin (DJ Andrew Genus) on Radio PVS and Mixcloud. Check out Wendy's stuff on Etsy. Go see a 200-year-old condom in Amsterdam! (or at least read the article) Watch "ReDefining Patriotism by Isabella Brāveheart." https://youtu.be/4q_ot6yatyg?si=C1bIKfymcSwKwrQE    

Nonprofits - how do YOU communicate about the dreaded “overhead” expenses? You know that pie chart everyone uses to show how much money goes directly to programs? Yeah, I want to toss it out the window. We'll talk about why those “eight cents” on the dollar that cover essential administrative expenses are not wasted but actually crucial for keeping your nonprofit running smoothly. In this episode, we're tackling a nonprofit pro's question about updating an employee handbook. Should you hire a pro bono lawyer who DOESN'T do employment law or invest in an HR expert? Spoiler alert: Your uncle Larry, the PI lawyer, might not be the best fit here. It's all about making smart investments in your nonprofit's operations and HR to avoid headaches down the line. Trust me, you'll thank yourself later when you don't end up in a legal pickle. So, grab your headphones and join us for a lively chat about transforming how nonprofits communicate their spending to donors. We promise some laughs, a few rants, and a whole lot of practical advice. And remember, it's okay to spend money on things that keep your nonprofit running well! Let's rethink the way we tell our financial stories and embrace the true costs of running an amazing organization. In this episode, you will hear: Why you need to delete that outdated nonprofit overhead pie chart Whether pro bono is the right way to go with your employment law needs Some of our recommendations for tools to keep up with all the changing HR rules The real relationship between the back-office and your direct mission programming How you can REALLY communicate success to your donors What your fiduciary duties really have to do with all our worries about “overhead” Resources from this Episode Propel Article - A Graphic Re-Visioning of Nonprofit Overhead: https://propelnonprofits.org/blog/a-graphic-re-visioning-of-nonprofit-overhead/ The Five Whys: https://en.wikipedia.org/wiki/Five_whys Sign up for the Birken Law Email list: https://birkenlaw.com/signup/ Facebook page: https://www.facebook.com/birkenlaw Follow and Review: We'd love for you to follow us if you haven't yet. Click that purple '+' in the top right corner of your Apple Podcasts app. We'd love it even more if you could drop a review or 5-star rating over on Apple Podcasts. Simply select “Ratings and Reviews” and “Write a Review” then a quick line with your favorite part of the episode. It only takes a second and it helps spread the word about the podcast. Episode Credits If you like this podcast and are thinking of creating your own, consider talking to my producer, Emerald City Productions. They helped me grow and produce the podcast you are listening to right now. Find out more at https://emeraldcitypro.com Let them know we sent you.

UTP372 Chillout filosófico ………………………………………………………………………………………. Conductor del programa UTP Ramón Valero @tecn_preocupado Canal en Telegram @UnTecnicoPreocupado Un técnico Preocupado un FP2 IVOOX UTP http://cutt.ly/dzhhGrf BLOG http://cutt.ly/dzhh2LX Ayúdame desde mi Crowfunding aquí https://cutt.ly/W0DsPVq Invitados Dra Yane #JusticiaParaUTP @ayec98_2 Médico y Buscadora de la verdad. Con Dios siempre! No permito q me dividan c/izq -derecha, raza, religión ni nada de la Creación. https://youtu.be/TXEEZUYd4c0 …. losvengadores3 @Vengadores33 SOΨ ραrτε δε lα GΓλΠ MΣΠΤΣ CΓΣλDOΓλ LA CLASE POLÍTICACA DEBE SER DESINTEGRADA% onu NO ESTAMOS JUGANDO …. Nunkálo Zabras @Nklo_Zabras ALL WAYS WHAT XING …. Fernando Beltrán @nenucosinpanial @venusmelibra ………………………………………………………………………………………. Enlaces citados en el podcast: AYUDA A TRAVÉS DE LA COMPRA DE MIS LIBROS https://tecnicopreocupado.com/2024/11/16/ayuda-a-traves-de-la-compra-de-mis-libros/ ………………………………………………………………………………………. Música utilizada en este podcast: Tema inicial Heros Epílogo Con$pirazion - semillas https://youtu.be/7Yxwvf8nG6I?feature=shared

What if thriving at work wasn't a nice-to-have, but a human right?

Supio, an AI-driven platform developed specifically for personal injury lawyers, has been generating a lot of buzz. On the heels of reporting record growth last year and raising $25 million in Series A funding in October, last month it raised another $60 million in a Series B round. But what do the lawyers who use the platform think of it? On today's LawNext, we hear from one of those lawyers, as well as from the company's cofounder and CEO. Our guests today are:   Tyler Schneider, managing partner of the personal injury law firm TorHoerman Law. Schneider was an early adopter of Supio. He and his firm used it to help obtain a $495 million verdict against Abbott Labs in a case involving allegations that cow's milk-based infant formula caused intestinal inflammation in premature babies. Jerry Zhou, the CEO of Supio who cofounded it in 2021 together with his childhood friend and coworker Kyle Lam after having held product management and engineering roles at Microsoft and Avalara.    In their conversation with host Bob Ambrogi, Zhou and Schneider talk about the development of Supio, its real-world impact on plaintiffs' lawyers, and their wish lists for further development of the product. They also share their thoughts on how AI is likely to reshape PI practice more broadly.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). SpeakWrite: Save time with fast, human-powered legal transcription—so you can focus on your practice   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Grigore Roșu is a professor of computer science at the University of Illinois and a former NASA engineer, where he developed the K Framework - an open-source “Rosetta Stone” for programming language semantics. A day-one contributor to the Ethereum Foundation, he later founded Runtime Verification, now the leading formal verification company in Web3. In 2023, he founded Pi Squared with the vision of bringing the next million developers to Web3 by utilizing his revolutionary K Framework. Why you should listen Pi Squared solves the fragmentation and trust limitations of today's blockchain infrastructure by enabling verifiable, cross-chain computation and settlement, so apps, agents, and protocols can interact across ecosystems without relying on bridges, centralized parties, or unprovable logic. It's the missing trust layer for a modular, interoperable, and enterprise-ready Web3. Pi Squared's core offering is its Verifiable Settlement Layer (VSL)—essentially a decentralized, programmable foundation that wraps any action (data storage, transactions, computation) into a cryptographically sealed “claim.” These claims are verified by a global network of validators, settled via their high-performance FastSet consensus protocol, and become instantly accessible across chains and environments—all without intermediaries or trust assumptions. VSL enables fast, provable, cross-ecosystem settlements—serving AI, blockchains, or any off-chain systems. Already live on devnet, Pi Squared showcases powerful use cases like cross-chain asset bridging (e.g., via Wormhole NTT), blockchain state mirroring, and auditable AI pipelines via Trusted Execution Environments. Their system dramatically reduces redundant computation in blockchains—one node computes and proves, and everyone else verifies in milliseconds—boosting throughput, slashing energy use, and minimizing vulnerabilities. Think verifiability everywhere—from remote compute and DeFi to AI inference—supercharged by formal-language-backed proofs. Pi² is stitching formal verification, zero-knowledge proofs, and cross-chain interoperability into one fast, composable layer. No fluff, no trust—just proof. Supporting links Stabull Finance Pi Network Andy on Twitter  Brave New Coin on Twitter Brave New Coin If you enjoyed the show please subscribe to the Crypto Conversation and give us a 5-star rating and a positive review in whatever podcast app you are using.

Noticias Virgas ✨Vacaciones of Pi: devs consiguen Switchs 2 y tiempo libreSe cae un kickstarter y también sus 300 mil dólares recaudadosChorros roban 3 mil Switchs 2Masahiro Sakurai es pro inteligencia artificialAnuncian que se viene Spaceballs 2, con Mel Brooks y Rick MoranisSe estrena Elio de Pixar, y le va muy malJueguitos que Jugamos

Silêman Zandînan tev malbata xwe, di sala 2018an de gihîştin Australya. Ji zarokatiya xwe ve hewesa wî ji bo futbolê heye. Piştî kutakirina korsê hekemiyê, ew niha di Queensland FQPL1 û FQPL2 de, ku duyemîn asta herî bilind a futbolê li Queensland temsîl dikin, hekemiyê dike. Silêman dixwaze rojekê ji bo tîmê neteweyî yê futbola Australyayê hekemiyê bike.

What universal truths do you believe in? This week, Joey and Jess talk about database shapes, LLMs, collective human intelligence, apple eating, folk wisdom, and Pi. They don't talk about apple pie, though. references West End Girls Ethan Mollic on the "universal geometry" of meaning The Platonic Representation Hypothesis Doctor Dillamond's Classroom Algospeak: How Social Media is Transforming the Future of Language Study: Association Between Apple Consumption and Physician Visits Honeycrisp apples 

Dr. Allison Zibelli and Dr. Rebecca Shatsky discuss advances in breast cancer research that were presented at the 2025 ASCO Annual Meeting, including a potential new standard of care for HER2+ breast cancer, the future of ER+ breast cancer management, and innovations in triple negative breast cancer therapy. Transcript Dr. Allison Zibelli: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Allison Zibelli, your guest host of the podcast today. I'm an associate professor of medicine and a breast medical oncologist at the Sidney Kimmel Comprehensive Cancer Center at Jefferson Health. There was a substantial amount of exciting breast cancer data presented at the 2025 ASCO Annual Meeting, and I'm delighted to be joined by Dr. Rebecca Shatsky today to discuss some of these key advancements. Dr. Shatsky is an associate professor of medicine at UC San Diego and the head of breast medical oncology at the UC San Diego Health Moores Cancer Center, where she also serves as the director of the Breast Cancer Clinical Trials Program and the Inflammatory and Triple-Negative Breast Cancer Program.  Our full disclosures are available in the transcript of this episode. Dr. Shatsky, it's great to have you on the podcast today. Dr. Rebecca Shatsky: Thanks, Dr. Zibelli. It's wonderful to be here. Dr. Allison Zibelli: So, we're starting with DESTINY-Breast09, which was trastuzumab deruxtecan and pertuzumab versus our more standard regimen of taxane, trastuzumab pertuzumab for first-line treatment of metastatic HER2-positive breast cancer. Could you tell us a little bit about the study? Dr. Rebecca Shatsky: Yeah, absolutely. So, this was a long-awaited study. When T-DXd, or trastuzumab deruxtecan, really hit the market, a lot of these DESTINY-Breast trials were started around the same time. Now, this was a global, randomized, phase 3 study presented by Dr. Sara Tolaney from the Dana-Farber Cancer Institute of Harvard in Boston. It was assessing essentially T-DXd in the first-line setting for metastatic HER2-positive breast cancer in addition to pertuzumab. And that was randomized against our standard-of-care regimen, which was established over a decade ago by the CLEOPATRA trial, and we've all been using that internationally for at least the past 10 years. So, this was a large trial, and it was one-to-one-to-one of patients getting T-DXd plus pertuzumab, T-DXd alone, or THP, which mostly is used as docetaxel and trastuzumab and pertuzumab every three weeks for six cycles. And this was in over 1,000 patients; it was 1,159 patients with metastatic HER2-positive breast cancer. This was a very interesting trial. It was looking at the use of trastuzumab deruxtecan, but patients were started on this treatment for their first-line metastatic HER2-positive breast cancer with no end date to their T-DXd. So, it was, you know, you were started on T-DXd every 3 weeks until progression. Now, CLEOPATRA is a little bit different than that, though, as we know. So, CLEOPATRA has a taxane plus trastuzumab and pertuzumab. But generally, patients drop the taxane after about six to seven cycles because, as we know, you can't be really on a taxane indefinitely. You get pretty substantial neuropathy as well as cytopenias, other things that end up happening. And so, in general, that regimen has sort of a limited time course for its chemotherapy portion, and the patients maintained after the taxane is dropped on their trastuzumab and their pertuzumab, plus or minus endocrine therapy if the investigator so desires. And the primary endpoint of the trial was progression-free survival by blinded, independent central review (BICR) in the intent-to-treat population. And then it had its other endpoints as overall survival, investigator-assessed progression-free survival, objective response rates, and duration of response, and of course, safety. As far as the results of this trial, so, I think that most of us key opinion leaders in breast oncology were expecting that this was going to be a positive trial. And it surely was. I mean, this is a really, really active drug, especially in HER2-positive disease, of course. So, the DESTINY-Breast03 data really established that, that this is a very effective treatment in HER2-positive metastatic breast cancer. And this trial really, again, showed that. So, there were 383 patients that ended up on the trastuzumab plus deruxtecan plus pertuzumab arm, and 387 got THP, the CLEOPATRA regimen. What was really interesting also to note of this before I go on to the results was that 52% of patients on this trial had de novo metastatic disease. And that's pretty unusual for any kind of metastatic breast cancer trial. It kind of shows you, though, just how aggressive this disease is, that a lot of patients, they present with de novo metastatic disease. It's also reflecting the global nature of this trial where maybe the screening efforts are a little bit less than maybe in the United States, and more patients are presenting as later stage because to have a metastatic breast cancer trial in the United States with 52% de novo metastatic disease doesn't usually happen. But regardless, the disease characteristics were pretty well matched between the two groups. 54% of the patients were triple positive, or you could say hormone-positive because whether they were PR positive or ER positive and PR negative doesn't really matter in this disease. And so, the interim data cutoff was February of this year, of 2025. So, the follow-up so far has been about 29 months, so the data is still really immature, only 38% mature for progression-free survival interim analysis. But what we saw is that T-DXd plus pertuzumab, it really improved progression-free survival. It had a hazard ratio that was pretty phenomenal at 0.56 with a confidence interval that was pretty narrow of 0.44 to 0.71. So, very highly statistically significant data here. The progression-free survival was consistent across all subgroups. Overall survival, very much immature at this time, but of course, the trend is towards an overall survival benefit for the T-DXd group. The median durable response with T-DXd plus pertuzumab exceeded 3 years. Now, importantly, though, I want to stress this, is grade 3 or above treatment-emergent adverse events occurred in both subgroups pretty equally. But there were 2 deaths in the T-DXd group due to interstitial lung disease. And there was a 12.1% adjudicated drug-induced interstitial lung disease/pneumonitis event rate in the T-DXd group and only 1%, and it was grade 1-2, in the THP group. So, that's really the caveat of this therapy, is we know that a percentage of patients are going to get interstitial lung disease, and that some may have very serious adverse events from it. So, that's always something I keep in the back of my mind when I treat patients with T-DXd. And so, overall, the conclusions of the trial were pretty much a slam dunk. T-DXd plus pertuzumab, it had a highly statistically significant and clinically meaningful improvement in progression-free survival versus the CLEOPATRA regimen. And that was across all subgroups for first-line metastatic HER2-positive breast cancer here. And so, yeah, the data was pretty impressive. Just to go into the overall response rate, because that's always super important as well, you had 85.1% of patients having a confirmed overall RECIST response rate in the T-DXd plus pertuzumab group and a 78.6 in the CLEOPATRA group. The complete CR rate, complete response was 15.1% in the T-DXd group and 8.5 in the CLEOPATRA regimen. And it was really an effective regimen in this group, of course. Dr. Allison Zibelli: So, the investigators say at the end of their abstract that this is the new standard of care. Would you agree with that statement? Dr. Rebecca Shatsky: Yeah, that was a bold statement to make because I would say in the United States, not necessarily at the moment because the quality of life here, you have to think really hard about. Because one thing that's really important about the DESTINY-Breast09 data is that this was very much an international trial, and in many of the countries where patients enrolled on this, they were not able to access T-DXd off trial. And so, for them, this means T-DXd now or potentially never. And so, that is a really big difference whereas internationally, that may mean standard of care. However, in the US, patients have no issues accessing T-DXd in the second- or third-line settings. And right now, it's the standard of care in the second line in the United States, with all patients basically getting this second-line therapy except for some unique patients where they may be doing a PATINA trial regimen, which we saw at San Antonio Breast Cancer in 2024 of the triple-positive patients getting hormonal therapy plus palbociclib, which had a really great durable response. That was super impressive as well. Or there is the patient that the investigator can pick KADCYLA because the patient really wants to preserve their hair or maybe it's more indolent disease. But the quality of life on T-DXd indefinitely in the first-line setting is a big deal because, again, that CLEOPATRA regimen allows patients to drop their chemotherapy component about five to six months in. And with this, you're on a drug that feels very chemo-heavy indefinitely. And so, I think there's a lot more to investigate as far as what we're going to do with this data in the United States because it's a lot to commit a patient in the first-line metastatic setting. These de novo metastatic patients, some of them may be cured, honestly, on the HER2-targeting regimen. That's something we see these days. Dr. Allison Zibelli: So, very interesting trial. I'm sure we'll be talking about this for a long time.  So, let's move on to SERENA-6, which was, I thought, a very interesting trial. This trial took patients with ER positive, advanced breast cancer after six months on an AI (aromatase inhibitor) and a CDK4/6 inhibitor. They did ctDNA every two to three months, and when they saw an ESR1 mutation emerge, they changed half of the patients to camizestrant plus CDK4/6 and kept the other half on the AI plus CDK4/6. Can you talk about that trial a little bit, please? Dr. Rebecca Shatsky: Yeah, so this was a big trial at ASCO25. This was presented as a Plenary Session. So, this was camizestrant plus a CDK4/6 inhibitor, and it could have been any of the three, so palbo, ribo, or abemaciclib in the first-line metastatic hormone-positive population, and patients were on an AI with that. They were, interestingly, tested by ctDNA at baseline to see if they had an ESR1 mutation. So, that was an interesting feature of this trial. But patients had to have already been on their CDK4/6 inhibitor plus AI for at least 6 months to enroll. And then, as you mentioned, they got ctDNA testing every 2 to 3 months. This was also a phase 3, double-blind, international trial. And I do want to highlight again, international here, because that's important when we're considering some of this data in the U.S. because it influences some of the results. So, this was presented by Dr. Nick Turner of the Royal Marsden in the UK. So, just a little bit of background for our listeners on ESR1 mutations and why they're important. This is the most common, basically, acquired resistance mutation to patients being treated with aromatase inhibitors. We know that treatment with aromatase inhibitors can induce this. It makes a conformational change in the estrogen receptor that makes the estrogen receptor constitutively active, which allows the cell to signal despite the influence of the aromatase inhibitor to decrease the estrogen production so that the ligand binding doesn't matter as much as far as the cell signaling and transcription is concerned. And camizestrant, you know, as an oral SERD, just to explain that a little bit too; these are estrogen receptor degraders. The first-in-class of a selective estrogen receptor degrader to make it to market was fulvestrant. And that's really been our standard-of-care estrogen degrader for the past 25 years, almost 25 years. And so, a lot of us are just looking for some of these oral SERDs to replace that. But regardless, they do tend to work in the ESR1-mutated population. And we know that patients on aromatase inhibitors, the estimates of patients developing an ESR1 mutation, depending on which study you look at, somewhere between 30% to 50% overall, patients will develop this mutation with hormone-positive metastatic breast cancer. There is a small percentage of patients that have these at baseline without even treatment of an aromatase inhibitor. The estimates of that are somewhere between 0.5 and up to 5%, depending on the trial you look at and the population. But regardless, there is a chance someone on their CDK4/6 inhibitor plus AI at 6 months' time course could have had an ESR1 mutation at that time. But anyway, so they got this ctDNA every 2 to 3 months, and once they were found to develop an ESR1 mutation, the patients were then switched to the oral SERD. AstraZeneca's version of the oral SERD is camizestrant, 75 mg daily. And then their type of CDK4/6 inhibitor was maintained, so they didn't switch the brand of their CDK4/6 inhibitor, importantly. And that was looked at then for progression-free survival, but these were patients with measurable disease by RECIST version 1.1. And the data cut off here was November of 2024. This was a big trial, you know, and I think that that's influential here because this was 3,256 patients, and that's a lot of patients. So, they were all eligible. And then 315 patients ended up being randomized to switch to camizestrant upon presence of that ESR1 mutation. So, that was 157 patients. And then the other half, so they were randomized 1:1, they continued on their AI without switching to an oral SERD. That was 158 patients. They were matched pretty well. And so, their baseline characteristics, you know, the two subgroups was good. But this was highly statistically significant data. I'm not going to diminish that in any way. Your hazard ratio was 0.44. Highly statistically significant confidence intervals. And you had a median progression-free survival in those that switched to camizestrant of 16 months, and then the non-switchers was 9.2 months. So, the progression-free survival benefit there was also consistent across the subgroups. And so, you had at 12 months, the PFS rate was 60.7% for the non-treatment group and 33.4% in the treatment group. What's interesting, though, is we don't have overall survival data. This is really immature, only 12% mature as far as overall survival. And again, because this was an international trial and patients in other countries right now do not have the access to oral SERDs that the United States does, the crossover rate, they were not allowed to crossover, and so, a very few patients, when we look at progression-free survival 2 and ultimately overall survival, were able to access an oral SERD in the off-trial here and in the non-treatment group. And so, that's really important as far as we look at these results. Adverse events were pretty minimal. These are very safe drugs, camizestrant and all the other oral SERDs. They have some mild toxicities. Camizestrant is known for something weird, which is called photopsia, which is some flashing lights in the periphery of the eye, but it doesn't seem to have any serious clinical significance that we know of. It has a little bit of bradycardia, but it's otherwise really well tolerated. You know, I hate to say that because that's very subjective, right? I'm not the one taking the drug. But it doesn't have any serious adverse events that would cause discontinuation. And that's really what we saw in the trial. The discontinuation rates were really low. But overall, I mean, this was a positive trial. SERENA-6 showed that switching to camizestrant at the first sign of an ESR1 mutation on CDK4/6 inhibitor plus AI improved progression-free survival. That's all we can really say from it right now. Dr. Allison Zibelli: So, let's move on to ASCENT-04, which was a bit more straightforward. Sacituzumab govitecan plus pembrolizumab versus chemotherapy plus pembrolizumab in PD-L1-positive, triple-negative breast cancer. Could you talk about that study? Dr. Rebecca Shatsky: Yeah, so this was also presented by the lovely Sara Tolaney from Dana-Farber. And this study made me really excited. And maybe that's because I'm a triple-negative breast cancer person. I mean, not to say that I don't treat hundreds of patients with hormone- positive, but our unmet needs in triple negative are huge because this is a disease where you have got to throw your best available therapy at it as soon as you can to improve survival because survival is so poor in this disease. The average survival with metastatic triple-negative breast cancer in the United States is still 13-18 months, and that's terrible. And so, for full disclosure, I did have this trial open at my site. I was one of the site PIs. I'm not the global PI of the study, obviously. So, what this study was was for patients who had had at least a progression-free survival of 6 months after their curative intent therapy or de novo metastatic disease. They were PD-L1 positive as assessed by the Dako 22C3 assay of greater than or equal to a CPS score of 10. So, that's what the KEYNOTE-355 trial was based on as well. So, standard definition of PD-L1 positive in breast cancer here. And basically, these patients were randomized 1:1 to either their sacituzumab govitecan plus pembrolizumab, day 1 they got both therapies, and then day 8 just the saci, as is standard for sacituzumab. And then the other group got the KEYNOTE-355 regimen. So, that is pembrolizumab with – your options are carbogem there, paclitaxel or nab-paclitaxel. And it's up to investigator's decision which upon those they decided. They followed these patients for disease progression or unacceptable toxicity. It was really an impressive trial in my opinion because we know already that this didn't just improve progression-free survival, because survival is so poor in this disease, of course, we know that it improved overall survival. It's trending towards that very much, and I think that's going to be shown immediately. And then the objective response rates were better, which is key in this disease because in the first-line setting, you've got a lot of people who, especially your relapsed TNBC that don't respond to anything. And you lose a ton of patients even in the first-line setting in this disease. And so, this was 222 patients to chemotherapy and pembro and 221 to sacituzumab plus pembro. Median follow-up has only been 14 months, so it's still super early here. Hazard ratio so far of progression-free survival is 0.65, highly statistically significant, narrow confidence intervals. And so, the median duration of response here for the saci group was 16.5 months versus 9.2 months. So, you're getting a 7-month progression-free survival benefit here, which in triple negative is pretty fantastic. I mean, this reminds me of when we saw the ASCENT data originally come out for sacituzumab, and we were all just so happy that we had this tool now that doubled progression-free and overall survival and made such a difference in this really horrible disease where patients do poorly. So, OS is technically immature here, but it's really trending very heavily towards improvement in overall survival. Importantly, the treatment-related adverse events in this, I mean, we know sacituzumab causes neutropenia, people who are experienced with this drug know how to manage it at this point. There wasn't any really unexpected treatment-related adverse events. You get some people with sacituzumab who have diarrhea. It's usually pretty manageable with some Imodium. So, it was cytopenias predominantly in this disease in this population that were highlighted as far as adverse events. But I'm going to be honest, like I was surprised that this wasn't the plenary over the SERENA-6 data because this, in my mind, there we have a practice-changing trial. I will immediately be trying to use this in my PD-L1 population because, to be honest, as a triple-negative breast cancer clinical specialist, when I get a patient with metastatic triple-negative breast cancer who's PD-L1 positive, I think, "Oh, thank God," because we know that part of the disease just does better in general. But now I have something that really could give them a durable response for much longer than I ever thought possible when I started really heavily treating this disease. And so, this was immediately practice-changing for me. Dr. Allison Zibelli: I think that it's pretty clear that this is at least an option, if not the option, for this group of patients. Dr. Rebecca Shatsky: Yeah, the duration of responses here was – it's just really important because, I mean, I do think this will make people live longer. Dr. Allison Zibelli: So, moving on to the final study that we're going to discuss today, neoCARHP (LBA500), which was neoadjuvant taxane plus trastuzumab, pertuzumab, plus or minus carbo(platin) in HER2-positive early breast cancer. I think this is a study a lot of us have been waiting for. What was the design and the results of this trial? Dr. Rebecca Shatsky: I was really excited about this as well because I'm one of those people that was waiting for this. This is a Chinese trial, so that is something to take note of. It wasn't an international trial, but it was a de-escalation trial which had become really popular in HER2-positive therapy because we know that we're overtreating HER2-positive breast cancer in a lot of patients. A lot of patients we're throwing the kitchen sink at it when maybe that is not necessary, and we can really de-escalate and try to personalize therapy a little bit better because these patients tend to do well. So, the standard of care, of course, in HER2-positive curative intent breast cancer with tumors that are greater than 2 cm is to give them the TCHP regimen, which is docetaxel, carboplatin, trastuzumab, and pertuzumab. And that was sort of established by several trials in the NeoSphere trial, and now it's been repeated in a lot of different studies as well. And so, that's really the standard of care that most people in the United States use for HER2-positive curative intent breast cancer. This was a trial to de-escalate the carboplatin, which I was super excited about because many of us who treat this disease a lot think carbo is the least important part of the therapy you're giving there. We don't really know that it's necessary. We've just been doing it for a long time, and we know that it adds a significant amount of toxicity. It causes thrombocytopenia, it causes severe nausea, really bad cytopenias that can be difficult in the last few cycles of this to manage. So, this trial was created. It randomized patients one to one with stage 2 and 3 HER2-positive breast cancer to either get THP, a taxane, pertuzumab, trastuzumab, similar to the what we do in first-line metastatic HER2-positive versus the whole TCHP with a carboplatin AUC of 6, which is what's pretty standard. And it was a non-inferiority trial, so important there. It wasn't to establish superiority of this regimen, which none of us, I think, were looking for it to. And it was a modified intent-to-treat population. And so, all patients got at least one cycle of this to be assessed as a standard for an intent-to-treat trial. And so, they assumed a pCR rate of about 62.8% for both groups. And, of course, it included both HER2-positive triple positives and ER negatives, which are, you know, a bit different diseases, to be honest, but we all kind of categorize them and treat them the same. And so, this trial was powered appropriately to detect a non-inferiority difference. And so, we had about 380 patients treated on both arms, and there was an absolute difference of only 1.8% of those treated with carbo versus those without. Which was fantastic because you really realized that de-escalation here may be something we can really do. And so, the patients who got, of course, the taxane regimen had fewer adverse events. They had way fewer grade 3 and 4 adverse events than the THP group. No treatment-associated deaths occur, which is pretty standard for- this is a pretty safe regimen, but it causes a lot of hospitalizations due to diarrhea, due to cytopenias, and neutropenic fever, of course. And so, I thought that this was something that I could potentially enact, you know, and be practice-changing. It's hard to say that when it's a trial that was only done in China, so it's not necessarily the United States population always. But I think for patients moving forward, especially those with, say, a 2.5 cm tumor, you know, node negative, those, I'd feel pretty comfortable not giving them the carboplatin here. Notes that I want to make about this population is that the majority were stage 2 and not stage 3. They weren't necessarily your inflammatory HER2-positive breast cancer patients. And that the taxane that was utilized in the trial is a little different than what we use in the United States. The patients were allowed to get nab-paclitaxel, which we don't have FDA approval for in the first-line curative intent setting for HER2-positive breast cancer in the United States. So, a lot of them got abraxane, and then they also got paclitaxel. We tend to use docetaxel every 3 weeks in the United States. So, just to point out that difference. We don't really know if that's important or not, but it's just a little bit different to the population we standardly treat. Dr. Allison Zibelli: So, are there patients that you would still give TCHP to? Dr. Rebecca Shatsky: Yeah, great question. I've been asked that a lot in the past like week since ASCO. I'd say in my inflammatory breast cancer patients, that's a group I do tend to sometimes throw the kitchen sink at. Now, I don't actually use AC in those because I know that that was the concern, but I think the TRAIN-2 trial really showed us you don't need to use Adriamycin in HER2-positive disease unless it's like refractory. So, I don't know that I would throw this on my stage 3C or inflammatory breast cancer patients yet because the majority of this were not stage 3. So, in your really highly lymph node positive patients, I'm a little bit hesitant to de-escalate them from the start. This is more of a like, if there's serious toxicity concerns, dropping carbo is absolutely fine here. Dr. Allison Zibelli: All right, great.  Thank you, Dr. Shatsky, for sharing your valuable insights with us on the ASCO Daily News Podcast today. Dr. Rebecca Shatsky: Thanks so much, Dr. Zibelli and ASCO Daily News. I really want to thank you for inviting me to talk about this today. It was really fun, and I hope you find my opinions on some of this valuable. And so, I just want to thank everybody and my listeners as well. Dr. Allison Zibelli: And thank you to our listeners for joining us today. You'll find the links to all the abstracts discussed today in the transcript of this episode. Finally, if you like this podcast and you learn things from it, please take a moment to rate, review, and describe because it helps other people find us wherever you get your podcasts. Thank you again. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. More on today's speakers Dr. Allison Zibelli Dr. Rebecca Shatsky @Dr_RShatsky Follow ASCO on social media:  @ASCO on Twitter  @ASCO on Bluesky  ASCO on Facebook  ASCO on LinkedIn   Disclosures: Dr. Allison Zibelli: No relationships to disclose Dr. Rebecca Shatsky: Consulting or Advisory Role: Stemline, Astra Zeneca, Endeavor BioMedicines, Lilly, Novartis, TEMPUS, Guardant Health, Daiichi Sankyo/Astra Zeneca, Pfizer Research Funding (Inst.): OBI Pharma, Astra Zeneca, Greenwich LifeSciences, Briacell, Gilead, OnKure, QuantumLeap Health, Stemline Therapeutics, Regor Therapeutics, Greenwich LifeSciences, Alterome Therapeutics  

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Soy Guillermo Gascón y estás leyendo FailAgain, la newsletter sobre creación de contenido que se entrega los domingos en tu correo electrónico.En el contenido de hoy te cuento:* Por qué el email de bienvenida es el más importante (y el que casi todos descuidan)* Mi nuevo sistema al descubierto: los bloques importantes que lo construyen.* Un recurso que te puede ahorrar meses de dudas si quieres lanzar tu newsletter desde ceroPrepárate para optimizar la pieza clave de tu sistema.Hoy quiero hablarte del email más rentable y a la vez más olvidado de cualquier newsletter: el de bienvenida.Ese correo automático que se envía cuando alguien se suscribe.Al principio, yo tampoco le daba mucha importancia. Lo veía como un simple "gracias por suscribirte" y ciao. Un trámite. Pero con el tiempo, y después de ver las métricas, me di cuenta de una cosa que es demoledora:El email de bienvenida es el que tiene la tasa de apertura más alta. Y por goleada.No es raro que supere el 60% - 70%. Piénsalo: es el momento en el que la atención de tu nuevo suscriptor está al 100% contigo. Acaba de darte su correo y está esperando que le llegue algo.Pero su función va mucho más allá de causar una buena primera impresión. Es el primer elemento de una estrategia de éxito para tu newsletter.Cuando un suscriptor abre tu correo y, sobre todo, hace clic en algún enlace, le está enviando una señal potentísima a los servidores de Gmail y compañía. El mensaje es claro: "Oye, que esta persona y yo nos conocemos. Lo que me manda me interesa".Esa señal mejora tu reputación y aumenta las probabilidades de que tus futuros correos lleguen a la bandeja de entrada. Por eso, tu email de bienvenida no puede ser un simple trámite.De hecho, acabo de rediseñar el mío por completo para que sea el inicio de un sistema inteligente. Y te lo voy a desgranar aquí, pieza por pieza.Así funciona mi nuevo email de bienvenidaMi sistema ya no es un saludo y un enlace. Es una conversación estructurada en 5 bloques clave.Bloque 1: Conexión inmediataLo primero es que la persona piense: "Vale, este tío me entiende". Nada de rollos. Voy directo a su dolor: "construir un proyecto que nos apasione, y que crezca sin morir en el intento". Es un "no va a ser fácil, pero estoy contigo en esto".Bloque 2: El Regalo (con un pequeño giro)Acto seguido, entrego valor masivo (como diría Llados). Un taller práctico para crear un plan de contenido. Pero no es una descarga directa. Para acceder, pido contestar a 3 preguntas. ¿Por qué?* Provoco un clic: La interacción que le encanta a los gestores de correo.* Es un intercambio justo: Me das feedback sobre tus retos y, a cambio, no solo te llevas el taller, sino que me ayudas a que el contenido futuro esté más afinado a lo que de verdad necesitas. Ganas tú, gano yo.Bloque 3: Mi historia y mi porquéUna vez he entregado valor, me presento. Pero no con un currículum. Cuento mi historia, la de verdad: la de haberme quemado, la del síndrome del impostor... Cuento que FailAgain nació de esa frustración. Esto genera confianza. Dejo de ser un logo para ser una persona con una misión.Bloque 4: La promesaDespués de la historia, pongo las cartas sobre la mesa. Le digo exactamente qué va a recibir a partir de ahora: sistemas probados, procesos sin filtro y herramientas que suman. Gestiono sus expectativas para que sepa a qué atenerse. Cero sorpresas, cero humo.Bloque 5: Cierre y P.D. con trucoCierro de forma cercana y uso la posdata, que sé que todo el mundo lee, para las "tareas". Ahí le pido que mueva el correo a la bandeja principal y le recuerdo que acceda al taller. Es una forma de dar instrucciones sin que suene a orden militar.Vale, pero esto es solo el primer ladrillo...Tener un email de bienvenida potente es crucial. Es el cimiento. Pero una newsletter es un edificio entero.Si ahora mismo sientes que todo lo que rodea a crear una newsletter te abruma (la herramienta, la estrategia, el miedo a no saber qué escribir), quiero hablarte de algo que te va a abrir los ojos.Newsletter Fácil de Chus Naharro. Todo lo que tienes que aprender para poner en marcha una newsletter de forma seria, está en este curso.Tanto Chus como yo compartimos filosofía como creadores de contenido y su forma de trabajar (el "Método Farming"), es algo que no puedo dejar de recomendar: Sembrar, Cultivar y Cosechar. Se centra en construir una base sólida y una relación real con la audiencia, no en truquillos baratos.Esta formación es el camino más rápido para tener una newsletter con:* Claridad total: Sabrás exactamente cuál es tu temática, tu enfoque y ese valor diferencial que te hace único. Adiós al síndrome del impostor.* Un sistema anti-bloqueo: Chus te da un método sencillo para saber qué escribir en cada email y no volver a quedarte mirando la pantalla en blanco.* Confianza para vender: Aprenderás a integrar las ventas de forma natural y honesta, para que tu newsletter se convierta en un canal de ingresos sin sonar a teletienda.* Tu newsletter lista para enviar: Saldrás con todo configurado y preparado para lanzar en solo unos días, sin agobios ni líos técnicos.Si quieres dejar de dar vueltas y tener por fin un sistema paso a paso que funciona, la formación de Chus es el camino más directo que conozco.Mi objetivo con este email era enseñarte que el de bienvenida no es un correo más. Es una herramienta estratégica y si quieres hacer del email tu canal más importante te recomiendo que veas todo lo que tiene preparado Chus.Un saludo y a crear :)PD: Si rediseñas tu email siguiendo esto, mándamelo. Me encanta ver cómo aplicas estos sistemas y siempre puedo darte feedback específico.PD2: si quieres ver mi email de bienvenida completo y todos los bloques de información que contiene analizados, lo tienes en la comunidad Factoría Creativa This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.guitermo.com/subscribe

Oggi con Matteo e Raffaele facciamo un po' il giro, non tanto dell'Italia, ma delle notizie. Una di queste potrebbe far arrabbiare molto gli studenti al rientro dalla pausa estiva. Trascrizione interattiva e Vocab Helper Support Easy Italian and get interactive transcripts, live vocabulary and bonus content: easyitalian.fm/membership Come scaricare la trascrizione Apri l'episodio in Transcript Player (https://play.easyitalian.fm/episodes/e7e34c2tz24rx7674cub0) Scarica come HTML (https://www.dropbox.com/scl/fi/e7e34c2tz24rx7674cub0/easyitalianpodcast174_transcript.html?rlkey=jnedhmeocmf9bbhxddar19bjd&st=0vyu2d0o&dl=1) Scarica come PDF (https://www.dropbox.com/scl/fi/ygd5waux20l48e42woccj/easyitalianpodcast174_transcript.pdf?rlkey=m54d4pn3d9ev81m4n74rj78da&st=ct3uqpdi&dl=1) Vocabolario Scarica come text file (https://www.dropbox.com/scl/fi/o2eys39fwx9et526k44dp/easyitalianpodcast174_vocab.txt?rlkey=2af4qp3h4n3o5sosqhbhh6j1m&st=is741sm7&dl=1) Scarica come text file with semicolons (https://www.dropbox.com/scl/fi/brz1xeg8ro058kitfbw3p/easyitalianpodcast174_vocab-semicolon.txt?rlkey=215zpcfpiz8u0areqtxphqu51&st=1jwdqp5g&dl=1) (per app che utilizzano flashcard) Iscriviti usando il tuo feed RSS privatoper vedere la trascrizione e il vocab helper subito sulla tua applicazione per ascoltare i podcast sul tuo cellulare. Note dell'episodio What Italians Really Think About Their Politics - https://www.youtube.com/watch?v=BT7IvwSEUHE&t=7s Oggi si inizia dai banchi di scuola. Ma attenzione! Vietati i cellulari! Cosa ne pensate? Matteo e Raffaele ne parlano, e cercano di capire come funzionera'. Ma abbiamo proprio bisogno di avere sempre con noi il cellulare, e soprattutto, serve agli studenti? Il turista anonimo continua a colpire. Questa volta si sono seduti su una sedia. Quindi? Poveri turisti non possono nemmeno riposarsi un attimo tra un monumento ed un altro? Beh certo, possono riposarsi, ma non su una sedia di... Finiamo tutti a mare! Quest'anno le coste italiane sono apparentemente molto pulite, e c'e' una regione che ha vinto per essere la regione con il mare piu' pulito! Curiosi? Vi possiamo dare un indizio: Confina con Campania e Calabria. Indovinato? Trascrizione Raffaele: [0:23] Buongiorno Matteo. Matteo: [0:25] Buongiorno, come va? Raffaele: [0:28] Settimana scorsa avevo il fiatone perché avevo fatto le scale a piedi, attività fisica. Questa settimana ho il fiatone stando fermo. Matteo: [0:39] No, è arrivato il caldo. Raffaele: [0:42] 31 gradi, sopra il 60 per cento di umidità: si suda da fermi, si soffre maledettamente. Matteo: [0:54] Mannaggia. Speriamo che questa cosa non continui. Raffaele: [0:57] Sei andato via giusto in tempo. Il problema che mi pongo io, Matteo, è che se a giugno, a metà giugno, fa così caldo e si soffre così tanto, cosa succede a luglio e agosto? Cioè dove andiamo a finire? Matteo: [1:16] E dove andiamo a finire? Raffaele: [1:18] E pensa che ci sta ancora chi è sui banchi di scuola a studiare con questo caldo. Matteo: [1:29] La vita in Italia in questo momento è calda. Raffaele: [1:32] È molto molto calda. Tu, Matteo, ricordi quando hai fatto l'esame di maturità? La data. Matteo: [1:41] Era giugno, le prime due settimane di giugno. Raffaele: [1:45] Grosso modo di questi tempi. (Sì sì.) Io invece ebbi la sfortuna... il mio cognome inizia con la T, quando si selezionò la lettera per decidere da dove iniziare per fare gli esami orali, giustamente uscì proprio la A. Estratta a sorte la A, e quindi io ero l'ultimo di tutta la classe a fare l'esame. L'ho fatto, se non ricordo male, il 4 luglio. E sono andato a fare l'esame di maturità, non so se te l'ho mai raccontato, col costumino. Cioè il costume e sopra il pantalone: finito l'esame, la prova orale dell'esame di maturità, siamo andati direttamente al mare a festeggiare. Ma si può studiare con questo caldo? Si può stare sui libri a scuola con questo caldo? Matteo: [2:35] No, sicuramente no. Fortunatamente tutte le scuole, a parte gli esami, sono chiuse e riapriranno a settembre. Raffaele: [2:47] Sì, generalmente chiudono intorno al 10 giugno, ma già molto prima ci sono tanti studenti che, finite le interrogazioni, finiti i test, i compiti in classe, come si chiamano, lasciano la scuola generalmente verso la fine di maggio. E ha senso proprio per questo discorso del caldo, considera che non siamo neanche ancora in estate ma già fa così caldo. Quando rientreranno a scuola gli studenti, probabilmente troveranno una novità. Bello o brutta? Non lo so, bisogna chiederlo a loro. Matteo: [3:26] Ah, e che novità troveranno? Poveri studenti, poveri studenti. Raffaele: [3:31] Poveri. A partire da settembre 2025 il cellulare in classe sarà vietato anche agli studenti delle scuole superiori. Matteo: [3:42] E questa è una cosa interessante, è un approccio molto... non dittatoriale, mi sembra un po'... dittatoriale mi sembra troppo, però non me lo aspettavo. Raffaele: [3:55] È un approccio forte, no? È stato fatto l'esperimento con le scuole inferiori, chiamiamole così, quindi le scuole elementari, le scuole medie, e poi adesso si è deciso di espandere questo divieto alle scuole superiori. Alle scuole elementari è stato facilissimo: forse nessun bambino alle scuole elementari ha il cellulare. Anzi mi correggo: io conosco tanti bambini che hanno il cellulare in quarta o quinta elementare ma non lo portano proprio a scuola. Alle medie già comincia ad essere complicato perché un po' tutti hanno il cellulare. Al liceo, alle scuole superiori sarà complicato far rispettare questo divieto. Matteo: [4:44] È una cosa interessante anche perché sto cercando di pensare, cercando di empatizzare il più possibile con i ragazzi e i genitori, per quanto posso ovviamente, e non trovo un motivo per andare contro questa decisione: è giusto che tu non puoi usare il cellulare in classe. Raffaele: [5:12] Eh, siamo sempre nel discorso del libero arbitrio, no? In teoria gli studenti dovrebbero capire che non è il caso di utilizzare il cellulare durante la lezione. Spieghiamo un attimo bene come funziona a partire da settembre: praticamente all'ingresso in classe ci sarà una cassettina oppure si utilizzerà semplicemente il cassetto della cattedra dell'insegnante. E ogni studente che entra in classe, oppure quando entra il professore, i ragazzi devono consegnare il cellulare, mettere il cellulare in questa cassettina o nel cassetto, in modalità non disturbare, di modo che vibrazioni e suonerie non diano fastidio. E recuperare il cellulare in teoria alla fine della giornata ma in pratica quando il professore uscirà di classe, i ragazzi andranno a controllarsi le notifiche, salvo poi rimettere il cellulare a posto quando entra il professore dell'ora successiva. Ha senso così? Cioè alla fine è solo un togliere il cellulare agli alunni durante la lezione? Matteo: [6:27] Allora la questione è che abbiamo a che fare con ragazzi giovani che per una questione anche fisica hanno dei seri problemi a comportarsi in maniera logica. Perché si stanno ancora sviluppando e quindi hanno bisogno di avere a che fare con delle regole e con dei divieti, secondo me. Cioè non puoi basarti sempre e solo sulla logicità, e il ragionamento che dovrebbero fare gli studenti, che sono giovani. Raffaele: [7:14] Eh lo so, ma dirgli proprio "lasciate il cellulare qua, spegnete il cellulare, consegnatelo"... Potresti anche dire "spegnetelo però tenetelo voi, ci fidiamo." Perché poi alla fine è quello un po' il discorso. Tu dici: " Non mi fido." Matteo: [7:28] No, il discorso è proprio quello, il discorso è: si può arrivare a quello dopo una... è un po' come nelle disintossicazioni forti, tu mi insegni... No anche tu, se tu vuoi prendere meno caffè, sei arrivato in una situazione in cui ne stai prendendo tanto, non è che inizi a prenderne di meno. Vai un po' drastico i primi periodi. Raffaele: [7:55] Eh non lo so, non lo so, ci sono diversi approcci, per questo non è così semplice la questione, perché tu dici: il cellulare in classe è un male, quindi la soluzione è togliamo il cellulare. Matteo: [8:11] Ma in realtà il cellulare in classe è un male. Raffaele: [8:14] Dipende da cosa ci fai. Matteo: [8:16] Ma in questo momento lasciando stare il "vorrei che fosse", però se eliminiamo il "come vorrei che fosse la classe ideale oggi", il cellulare e l'uso del cellulare in classe distrae solamente. Raffaele: [8:40] Allora voglio chiarire un po' la mia posizione: io fondamentalmente sono d'accordo con te, nel senso che sono d'accordo che dire ad un tredicenne "tieni il cellulare acceso sul banco durante la lezione" è un invito a nozze per lui. E invece di sentirsi il professore di storia e filosofia, aprirà TikTok e si guarderà i video silenziosamente facendo finta di seguire. Quindi diciamo che è un modo per togliere questa distrazione. Idealmente non sarebbe necessario. Idealmente la lezione dovrebbe essere coinvolgente, e ti dirò di più, dovrebbe trovare un modo per coinvolgere i ragazzi attivamente. E perché non coinvolgere anche con l'uso del cellulare? Cioè per me la scuola dovrebbe andare verso una digitalizzazione massiccia, forte, soprattutto in Italia dove invece su questo siamo un po' indietro. Non ci sono abbastanza computer per tutti gli allievi, non ci sono i tablet per tutti e consentire l'utilizzo del cellulare, in maniera coordinata con l'insegnante eh, attenzione... può essere invece un modo per sopperire a questa mancanza. Idealmente, eh... Matteo: [10:03] Sono d'accordo con te. Idealmente. Ma poi basta che... ricordo le mie lezioni di informatica, e non so se tu hai mai fatto lezioni in aula computer in cui c'erano questi grandi computer, dietro i quali... erano così grandi che ti potevi nascondere dietro il monitor. E lo studente, il suo primo obiettivo quando... non il suo primo obiettivo nel senso che si sveglia e pensa che vuole fare questo.... Ma il cervello ha costanti, dà costanti impulsi per distrarti, sempre. E al primo momento noi, anche senza cellulari, perché entrambi abbiamo fatto i nostri studi durante un periodo in cui non c'era proprio il cellulare... Raffaele: [10:58] Usciva, ti dico la verità, si mandavano gli sms. Matteo: [11:01] Sì, vabbè, però, insomma, era così, non... oltretutto era vietato, non potevi metterti col cellulare sul banco. Raffaele: [11:15] Però mi ricordo che già all'ultimo anno di liceo noi avevamo quasi tutti il cellulare e ci mandavamo i messaggini, quindi già si presentava il problema. Non potevi, chiaro che non potevi, però nessuno ti sequestrava nulla. Matteo: [11:28] Eh no, però la questione è che adesso non solo puoi mandare messaggini ma per esempio puoi compromettere un compito in classe, certo probabilmente ci saranno delle metodologie per i quali se c'è il compito in classe il cellulare viene tolto o comunque viene spento o non lo so. Però già la maggior parte degli studenti è ignorante... Ma buttiamoli proprio i cellulari... Cioè secondo me il cellulare genericamente dovrebbe essere iniziato ad usare a 20 anni, perché crea una serie di problemi. A meno che non si inizi a scuola a fare educazione digitale, che può essere anche fatta con carta e penna, però ti iniziano ad educare a come usare i social, come comportarsi, cosa fare, cosa non fare, cosa evitare. Raffaele: [12:31] E qui convergiamo, Matteo: hai detto una cosa bellissima, esattamente quello che proporrei di fare io, perché il problema secondo me non è la distrazione del cellulare sul banco. Certo le elimini, non hai più la distrazione. Ma non educhi a gestire il cellulare, e secondo me il problema di tanti ragazzi di oggi è proprio quello. Pensa che la proposta successiva di questo governo è: niente social media sotto i 15 anni. E di questo poi ne riparliamo magari in un'altra puntata. Però è per dire che secondo me anche questo divieto non è per non far distrarre gli studenti, è per evitare che magari anche gli episodi di bullismo in classe vengano ripresi con i cellulari, poi questi video girino nelle chat, sui social media e creino problemi poi giganteschi. Il problema è proprio quello. Il problema è cosa ci fanno i ragazzi col cellulare. E quindi dovrebbero essere educati all'utilizzo consapevole del cellulare. Secondo me a partire dalla scuola, quindi non sequestrando i cellulari, ma insegnando come usare i cellulari in maniera utile e non fare danni con i cellulari. E poi chiaramente c'è l'altra faccia della medaglia, ovvero una volta usciti da scuola non è che "cellulare libero per tutti, tutta la giornata". Perché attualmente è così, no? La scuola dice "vi vieto il cellulare a scuola, a casa decideranno i genitori, fate quello che volete." Il problema è poi che in questa altra metà della giornata, anche i genitori, anche la famiglia deve continuare con questa educazione all'utilizzo della tecnologia. Matteo: [14:19] Sì sì sì sì, purtroppo l'educazione è un grande problema. Raffaele: [14:33] Dove eravamo rimasti? Ma inteso settimana scorsa? A Roma con i turisti che si rubavano le statue e le basi delle colonne: è successo di nuovo? Non dirmi che è successo di nuovo... Matteo: [14:49] È successo, più o meno. Niente monopattini, niente basi di colonne, ma a quanto pare dei turisti hanno fatto un guaio. Raffaele: [14:59] Un guaio bello grosso e bello caro, molto caro. Parliamo ancora di comportamenti sbagliati nei musei. Questa volta siamo a Verona, un museo che si chiama Palazzo Maffei, che ospita delle opere d'arte. In particolare un'opera d'arte di un artista contemporaneo italiano che si chiama Nicola Bolla, che ha riprodotto una sedia ispirata a uno dei quadri più famosi di Van Gogh. E l'ha riprodotta totalmente fatta di cristallo e Swarovski, quindi uno degli oggetti più fragili per definizione. Raffaele: [15:48] Ebbene, durante una visita a questo museo, una coppia quasi anziana, adesso non sappiamo molti dati, vediamo soltanto le immagini dei video di sorveglianza. Questa coppia di signori anziani, aspetta l'uscita della guardia poi si avvicina furtivamente alla sedia, che si chiama proprio "la sedia di Van Gogh". Fin lì tutto bene, puoi avvicinarti, puoi fare le tue foto. Solo che a un certo punto lui si china e si siede, si appoggia sull'opera d'arte. Adesso, secondo te: è fatta di cristallo, come può andare a finire? (Malissimo. In frantumi.) Esatto. La sedia si è immediatamente spaccata. E, tu dirai: i due mortificati avranno informato la guardia che stava poco distante in qualche altra sala. "Guardate, è successo questo, non volevo, l'ho urtata e si è rotta." Invece i furbastri sono scappati via, hanno fatto finta di nulla, hanno lasciato il museo e si sono dileguati. Le guardie del museo si sono accorte del danno troppo tardi, perché sono uscite dal museo per provare a rintracciare i colpevoli ma non li hanno potuti trovare. E quindi il museo ha fatto una denuncia contro ignoti, si dice in questo caso: è una cosa che è possibile fare quando non sai chi ha fatto il danno, il furto, fai una denuncia contro ignoti. E i carabinieri in questo caso si sono attivati, hanno preso la situazione molto seriamente, dal video sono riconoscibili in volto i due, si vede per bene l'abbigliamento, gli oggetti che portano con sé. E quindi per adesso non l'hanno trovati, ma chissà che non li troveranno a breve. Matteo: [17:55] Beh, ci sono spera... speriamo, ma non tanto per una questione di, come dire: "Voglio punirli". Però non vorrei che iniziasse questo nuovo sport di "fa il danno e poi scappa". Raffaele: [18:15] Sì, no, non va bene. Il danno, tra l'altro, la sedia vale tra i 15.000 e i 50.000 euro, quindi non parliamo di milioni di euro, però comunque è un danno non da poco. E hanno contattato l'artista: fortunatamente l'artista, dopo aver constatato i danni ha detto "ok, sì, la possiamo sistemare." Tra l'altro l'artista è stato intervistato dai giornali e l'ha presa sul filosofico, diciamo così. Ha detto "No, non ci sono rimasto male anzi ci ho visto qualcosa di ironico e positivo, mi è sembrata quasi una performance di arte moderna". Matteo: [19:00] Vabbè certo, è stata registrata, l'ha vista forse. Raffaele: [19:04] Eh, si sarà fatto una risata e ha detto "Mi ha dato persino lo spunto per la prossima opera da realizzare". Matteo: [19:11] Ah, incredibile. Raffaele: [19:13] "Sedia spezzata con turista immortalato accovacciato", chissà. Secondo me questo è il calore. Troppo caldo sta dando alla testa. Hai un antidoto per tutto questo caldo? Matteo: [19:26] Eh certo: andate a mare! Raffaele: [19:35] Eh vabbè ma il mare in Italia... Cioè l'Italia è tutta mare, è una penisola, c'è talmente tanto di quel mare che non sai dove andare. Dove andare a mare? Matteo: [19:48] Possiamo chiederlo ai mitici della bandiera blu. Raffaele: [19:55] La bandiera blu è uno degli strumenti che si utilizza in Italia per identificare le condizioni del mare delle spiagge italiane. Dare una bandiera blu ad una spiaggia vuol dire che lì l'acqua è pulita e bella, è l'idea di massima. Quest'anno in Italia, nel 2025, abbiamo 246 bandiere blu, quindi abbiamo almeno 246 posti da scegliere per avere l'acqua eccellente e addirittura recentemente c'è stato uno studio dei laboratori delle agenzie ambientali che hanno fatto una statistica e hanno visto che la regione con l'acqua più pulita, inteso meno inquinata in tutta Italia, è la Puglia. Il 99,7% delle acque è eccellente, ha una qualità eccellente, quindi l'acqua meno inquinata, praticamente 99,7% vuol dire che è perfetta. (Non male.) Più nello specifico, Matteo, tra l'altro le bandiere blu confermano questo trend e anche il maggior numero di bandiere blu in tutta Italia ce l'hanno Liguria, Puglia e Calabria, quindi si conferma la Puglia tra le migliori destinazioni. Tu sei stato in Puglia, sei stato al mare, ricordi qualche spiaggia, ti va di consigliarmi quella che secondo te è la spiaggia più bella d'Italia o la spiaggia più bella in cui sei stato in Italia? Matteo: [21:40] Allora, io sono stato in Puglia sì. Sono stato nel Gargano. Quindi la parte vicino al tallone dello stivale. E poi sono stato al confine con la Puglia, nel Molise, più verso nord. Siamo andati ogni tanto, siamo sconfinati in Puglia, spiagge un po' più sabbiose. Non sono andato ma dicono che un posto meraviglioso sono le isole Tremiti. Raffaele: [22:18] Eh sì. Matteo: [22:20] Che sono di fronte la Puglia e il Molise. Raffaele: [22:23] Esatto, sono un po' bistrattate, vuol dire maltrattate, spesso dimenticate quando si parla di isole italiane perché pensano tutti quanti alle isole della Sicilia. Mentre invece le Tremiti in Puglia sono una destinazione turistica bella, bella, bella. Matteo: [22:45] Sì. Raffaele: [22:46] Io sono stato in Puglia, non sono stato a mare in Puglia, perché sono stato in inverno, anche nei luoghi insomma che poi d'estate sono belli affollati. Però non ho avuto la possibilità di godere della spiaggia quando sono stato in Puglia. Quindi la mia selezione varia un po' tra Lazio e Campania soprattutto. Ed in particolare ti voglio raccomandare in Campania Marina d'Ascea, anche qui Bandiera Blu, una bella spiaggia ampia, mare molto pulito. Ma non solo, ce ne sono tante. C'è Palinuro. C'è un posto adesso non mi ricordo neanche più come... insomma, in quale zona specificamente si trova. Quando eravamo più ragazzini con la famiglia andavamo in un posto che si chiama "lo scoglio della tartaruga". E si trova a Vico Equense, in provincia di Napoli, non troppo lontano da Sorrento. Ed era un posto fantastico perché tu arrivavi, poi dovevi prendere la barchetta e la barchetta ti portava in questa spiaggia. Si chiama scoglio della tartaruga perché ci sono dei sassi poco distante dalla spiaggia che hanno proprio la forma di una tartaruga. E c'era l'abitudine, adesso non penso sia più consentito, di arrampicarsi su questa tartaruga e tuffarsi dalla testa o dal guscio della tartaruga. Non ci sei mai stato? Non ne hai mai sentito parlare? Matteo: [24:27] No, ricordo vagamente. A Vico Equense ci sono stato spesso quando ero piccolo e tutta quella parte lì è fantastica, ci sono delle spiagge e dei panorami e dei profumi bellissimi. Pino, mi ricordo sempre questo profumo di pino, l'albero e il mare che assieme creano un... Guarda, mi sento a mare adesso solo a pensarci. Raffaele: [25:01] Eh, ma io... infatti questo è un esercizio psicologico. Se penso alla spiaggia e al mare, automaticamente mi rinfresco. Nel Lazio ti consiglio una spiaggia che si chiama Serapo. Tecnicamente la zona, la cittadina a cui appartiene si chiama Gaeta, quindi siamo tra Napoli e Roma, non troppo lontano da Terracina che menziono sempre. Ed è insomma una bella bella spiaggia. Occhio al traffico, non facilissima da raggiungere, bisogna parcheggiare, poi fare delle scalinate... però insomma merita. Secondo alcuni la spiaggia più bella in Italia invece è la spiaggia dei conigli a Lampedusa. Matteo: [25:46] Non ci sono mai stato, è molto famosa tant'è vero che ne ho sentito già parlare. Raffaele: [25:52] Eh sì, effettivamente guardare le foto... sembra di guardare i Caraibi o addirittura le Maldive o la Polinesia. Matteo: [26:02] Ce ne sono tantissime che ricordo in Sardegna. Raffaele: [26:06] Esatto, volevo dire questo. Cioè che ognuno può avere la sua preferita, io non sono mai stato in Sardegna, però secondo tanti le spiagge più belle in Italia sono proprio in Sardegna. Secondo posto forse per la Sicilia e poi Puglia ed altre. Però grosso modo l'idea collettiva è questa: le spiagge più belle in Italia sono in Sardegna. Sei mai stato a mare in Sardegna? Matteo: [26:36] Sì, sono stato a mare in Sardegna per un paio d'anni da giovane, liceale, sono andato con gli amici, ed è stato, penso, il mare più bello che abbia mai visto in vita mia: bellissimo. Limpidissimo. Raffaele: [26:59] Facciamo così: me ne parli un poco nel nostro after show, ci spostiamo di là e approfondiamo questo argomento, e anche qua parliamo di qualche altra cosa. Matteo: [27:12] È vero perché ho fatto qualcosa. Raffaele: [27:15] Cosa hai fatto? Matteo: [27:16] Mistero? Raffaele: [27:17] Mistero: se volete sapere cosa ha combinato Matteo dovete seguirci nel nostro after show. Ricordate che è uno dei nostri bonus per i sostenitori, i membri della nostra comunità. Quindi non perdete tempo, cliccate sul link nelle show notes, diventate sostenitori di Easy Italian, riceverete l'after show, la trascrizione integrale interattiva della puntata, la traduzione multilingue, ed il Vocab Helper che mostra a schermo fino a 10 tra le parole più importanti o più difficili minuto per minuto. E che vuoi di più dalla vita? Matteo: [27:55] Una spiaggia e del mare. Raffaele: [27:59] Io stavo per dire un Lucano... Matteo: [28:01] Ciao. Ciao.

Shawn and Alex welcome Dr. Michael Niccole, plastic surgeon PI expert, to discuss everything from scar revision to long-term disfigurement claims, teaching how strategic cosmetic care can help your change a PI patient's life.

Pişti ku hindek hestî û keleyê serê mirovan dnava şikefta Şaneder li parêzgeha Hewlêr hate ditin. Bi hezaran xelk û geştîyar, şûnwarnas û dîroknas seredana wê şikeftê dikin. Rojane bi sedan şandên cûda cûda yên dîrokî, kesatîyên akademî serdana şikeftê dikin.

In this new episode, Tim Pilleri and Lance Reenstierna host a live fundraiser for the non-profit, Private Investigations For the Missing. This is part 2 of 2. Guests for the evening include Julie Murray (sister of Maura Murray), Bobby Taghavi (Golden State Killer task force), Dr. Trace Sargent (profiler & search dog trainer), private investigator Jason Watts (Brandon Lawson case), and PI's Greg Overacker and Lou Barry to discuss some new information in Brianna Maitland's disappearance. Follow Private Investigations For the Missing and please donate if you can: ⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠. ⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠. ⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠. ⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠. ⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠. Follow Dr. Trace Sargent: https://www.forensicinvestigations.org/. Get Greg's book on the disappearance of Brianna Maitland: https://books.bloatedtoe.com/book-contributor/gregory-j-overacker/. Check out Happy Mammoth and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://happymammoth.com⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mood and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://mood.com⁠⁠⁠⁠⁠⁠⁠⁠⁠. Main Theme by Kevin Macleod. Check out his work at ⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at ⁠⁠⁠⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠. TT:⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠. Spotify:⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠. Youtube:⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠. TT:⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠ Spotify:⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠. Youtube:⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠. Check out our entire network at⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Female Athlete Nutrition Podcast, host Lindsey Elizabeth Cortes, sports dietician and athlete, discusses menstrual health with guest Margo Harrison, a board-certified OB-GYN and founder of WaveBye Inc. They delve into the high expectations on women's bodies, nutritional confusion, and the impact of menstrual cycles on daily life and athletic performance.Margo shares the mission behind WaveBue Inc., a menstrual health company focused on enabling women to manage their menstrual symptoms effectively. The episode covers traditional and innovative treatments for menstrual pain, the importance of tracking and understanding one's cycle, and the evidence-based natural ingredients in WaveBye products, such as vitamin E, magnesium, inositol, and Chasteberry. Lindsey also provides insights from her own experience with the product and offers a special discount for listeners.Episode Highlights:01:26 Meet Our Guest: Margo Harrison02:10 Understanding Menstrual Health and Nutrition03:30 Personal Experiences and Insights06:30 Challenges and Solutions for Menstrual Pain23:54 Exploring WaveBye Products27:56 Addressing RED-S in Female Athletes30:29 Conclusion and Final Thoughts30:54 Understanding the Importance of Tracking Your Cycle32:00 Managing Irregular Cycles and Ovulation34:35 Ingredients and Their Benefits38:56 Personal Experiences and Testimonials47:30 Contraindications and Who Should Avoid These Products50:39 Final Thoughts and RecommendationsMargo is a board-certified OB/GYN who was an NIH-funded academic PI at the University of Colorado. Since leaving academic medicine, she has been a provider at Planned Parenthood of the Rocky Mountains and founded a femtech consulting firm that served over twenty venture-backed companies in the women's health space in areas of clinical research, strategy, business development, and medical affairs. She is now the founder and CEO of Wave Bye Inc., a menstrual health company that exists to enable women to fulfill their human potential. DISCOUNT CODE for 15% off: LINDSEYCORTESDirect referral link for discount: https://www.wavebye.co/?ref=LINDSEYCORTESVisit WaveBye's Website: http://wavebye.coFollow WaveBye:@wavebyeinc on Instagram@wavebyeinc on TikTok@WaveByeInc on YouTubeFor more information about the show, head to work with Lindsey on improving your nutrition, head to:http://www.lindseycortes.com/Join REDS Recovery Membership: http://www.lindseycortes.com/redsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

¿Creías que habías visto todo en el mundo de los videojuegos? Piénsalo otra vez. Desde un simulador del 23-F con Tejero como Pac-Man hasta citas románticas con palomas, pasando por recrear el asesinato de JFK o desahogarte con tu jefe usando un trasero de plástico... En este episodio exploramos los rincones más oscuros y perturbadores de la industria del videojuego. Títulos que desafían la lógica, que generaron polémicas masivas o que simplemente nacieron de mentes que claramente necesitaban unas vacaciones. ¿Qué lleva a alguien a crear un juego sobre el golpe de Tejero? ¿Por qué los japoneses pensaron que necesitábamos ligar con palomas? Te contamos las historias detrás de estos experimentos digitales que demuestran que vivimos en la época más extraña de la historia. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

In this new episode, Tim Pilleri and Lance Reenstierna host a live fundraiser for the non-profit, Private Investigations For the Missing. This is part 1 of 2. Guests for the evening include Julie Murray (sister of Maura Murray), Bobby Taghavi (Golden State Killer task force), Dr. Trace Sargent (profiler & search dog trainer), private investigator Jason Watts (Brandon Lawson case), and PI's Greg Overacker and Lou Barry to discuss some new information in Brianna Maitland's disappearance. Follow Private Investigations For the Missing and please donate if you can: ⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠. ⁠⁠⁠http://piftm.org/donate⁠⁠⁠. ⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠. ⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠. ⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠. Follow Julie Murray: https://www.mauramurraymissing.org/. Media Pressure podcast: https://www.mauramurraymissing.org/podcast.html. Julie on social media: https://www.tiktok.com/@mauramurraymissing. https://www.instagram.com/mysistermauramurray/. Bobby Taghavi's site: https://sweetjames.com/attorney/bobby-taghavi/. Bobby Taghavi on Instagram: https://www.instagram.com/bobbytaghavi. Check out Happy Mammoth and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠https://happymammoth.com⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mood and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠https://mood.com⁠⁠⁠⁠⁠⁠⁠⁠. Main Theme by Kevin Macleod. Check out his work at ⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠. Additional music by David Williams. See his work at ⁠⁠⁠⁠http://williamsflutes.com⁠⁠⁠⁠. Follow Missing: IG:⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠. TT:⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠. FB:⁠⁠ https://www.facebook.com/MissingCSM⁠⁠. X:⁠⁠ https://twitter.com/MissingCSM⁠⁠. Spotify:⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠. Youtube:⁠⁠ https://www.youtube.com/missingcsm⁠⁠. Apple:⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠. Follow Crawlspace: IG:⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠. TT:⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠. FB:⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠. X:⁠⁠ https://twitter.com/crawlspacepod.⁠⁠ Spotify:⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠. Youtube:⁠⁠ https://www.youtube.com/crawlspace⁠⁠. Apple:⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠. Check out our entire network at⁠⁠ http://crawlspace-media.com/⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

What happens when we take numbers seriously—not just at face value, but in terms of their actual impact on our lives? This week, Reid and Aria are joined by UK-based mathematician and media personality Hannah Fry to explore this deceptively simple question. From cancer diagnoses to dating apps, Hannah makes the case that understanding the math behind our decisions—and the "game" we're really playing—is essential to building a better future.  They discuss why regret minimization is often a better guide than raw percentages in assessing risks; Hannah's advice on finding love in a sea of swipe-rights; and how a well-framed question can be more powerful than the right answer. Plus, Inflection's Pi chimes in with a few Jane-Austen-themed math jokes. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/  Topics: 3:01 - Hellos and intros 3:15 - Considering hairdressing, instant feedback, and becoming a broadcaster 5:11 - Making math emotionally resonant 7:37 - Math as power and who gets to shape the future 9:10 - Understanding AI through probabilities and spectrums 12:01 - The emotional limits of statistics in medical decision-making 16:22 - Choosing the right “game” to optimize for 19:57 - How to build systems that self-correct 23:19 - Rethinking education and assessments in the AI era 26:42 - Updating dating advice for the AI age 30:03 - Real-life “Black Mirror” 36:11 - Storytelling vs. statistics 41:47 - Probability thinking, AI confidence, and useful heuristics 45:31 - Pi delivers math-themed Jane Austen jokes 47:15 - Rapid-fire questions Select mentions:  Google DeepMind: The Podcast The Mathematics of Love TED Talk When We Cease to Understand the World by Benjamín Labatut “Women also Snowboard: Overcoming Bias in Captioning Models” by Kaylee Burns, Lisa Anne Hendricks, Kate Saenko, Trevor Darrell, and Anna Rohrbach Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

ANTIFA THUG treats Police Officer's head like a Piñata! FAFO!

We surveyed over 250 attorneys across the country to find out what's really working in PI marketing and where firms are falling short. In this webinar replay from Rankings.io you'll get insights about how budget trends and channel performance to the growing divide between small and large firms. This webinar was packed with real data and real strategies you can act on now. UP NEXT:  AI Optimization for Lawyers: Search Has Changed. Most PI Firms Haven't. If your firm doesn't have a plan to adapt to AI-driven search, it won't be long before the flow of signed cases dries up. Date: June 24, 2025 Time: 12 PM - 1 PM CST WHERE: Rankings.io/Webinars  Plus, we'll open the floor for live Q&A so you can get actionable insights tailored to your firm. Register now at rankings.io/webinars to secure your spot and get an inside look at the future of legal marketing. Get Social! Personal Injury Mastermind (PIM) is on Instagram | YouTube | TikTok

Did you like the episode? Send me a text and let me know!!Mastering the Stigma of Asking for Help in EntrepreneurshipIn this episode of Business Conversations with Pi, host Skoob and AI co-host Pi, created by the innovative minds at Anthropic, delve into the importance of overcoming the stigma associated with asking for help in the entrepreneurial world. They discuss strategies to build a strong support network, the benefits of seeking assistance, and recommend valuable resources and books to further your understanding. Tune in to learn how vulnerability and mutual support can be the keys to your business success.Help Me! by Marianne PowerDaring Greatly by Brené BrownThe 5 Love Languages by Gary ChapmanNever Eat Alone by Keith Ferrazz00:00 Introduction to Business Conversations with Pi00:38 Meet Your Hosts: KU and Pi01:55 The Power of Asking for Help02:45 Strategies for Overcoming the Stigma03:43 Benefits of Asking for Help04:29 Who to Turn to for Help05:17 Recommended Reading for Entrepreneurs06:22 Final Thoughts and Encouragement06:54 Closing Remarks and Next Steps Thank you for being a Skoobeliever!! If you have questions about the show or you want to be a guest please contact me at one of these social mediasTwitter......... ..@djskoob2021 Facebook.........Facebook.com/skoobamiInstagram..... instagram.com/uepodcast2021tiktok....... @djskoob2021Email............... Uepodcast2021@gmail.com Skoob at Gettin' Basted Facebook PageAcross The Start Line Facebook Community If you would like to be coached on your entrepreneurial adventure please email me at for a 2 hour free discovery call! This is a $700 free gift to my Skoobelievers!! Contact me Now!! On Twitter @doittodaycoachdoingittodaycoaching@gmailcom

This week, I got to talk with Kimberly G. Giarratano about her newest installation in the noir Billie Levine series, Make a Killing! We dive into what was different about writing this one, how she landed on a luxury luggage company for the story, and how capitalism has seeped into college.Make a Killing SynopsisPrivate Investigator Billie Levine should be ecstatic. She's finally getting the cheating spouse cases she's always wanted. Nothing to do but sit back, snap incriminating photos, and get paid. Except Jeremy Yang is competing for work with his own P.I. firm. Advertising himself as “the man to get the job done” (insert eyeroll), he keeps swooping in and stealing prospective clients. Not to be outmaneuvered, Billie has offered her services to scorned women everywhere.Their rivalry escalates when Billie and Jeremy are hired by an ultra wealthy couple on opposite sides of a corporate takeover. When the bodies start dropping, Billie and Jeremy will have to join forces if they are to come out unscathed; they can kill each other later. Check Out My Stories Are My Religion SubstackCheck Out Author Social Media PackagesCheck out the Bookwild Community on PatreonCheck out the Imposter Hour Podcast with Liz and GregFollow @imbookwild on InstagramOther Co-hosts On Instagram:Gare Billings @gareindeedreadsSteph Lauer @books.in.badgerlandHalley Sutton @halleysutton25Brian Watson @readingwithbrian

Episode 243 :       Welcome to the next episode of Pi Perspectives. Matt is back with California PI, Joe Jones. Joe is a second-generation PI who built a great business with his brothers after learning from their dad. What do you do when you can't keep up with the growth? Stick around and find out. Please welcome Joe Jones and your host, NY Private Investigator, Matt Spaier  Links:      Matt's email: MatthewS@Satellitepi.com   Linkedin: Matthew Spaier       www.investigators-toolbox.com   Joe on Linkedin: Joseph Jones Email: Joejones@Magnals.com 
 PI-Perspectives Youtube link:  https://www.youtube.com/channel/UCYB3MaUg8k5w3k7UuvT6s0g Sponsors:     https://piinstitute.com/ https://www.skopenow.com https://researchfpr.com/ https://www.trackops.com FBI Tip Line https://tips.fbi.gov/home https://www.fbi.gov/contact-us/field-offices/newyork/about - (212) 384-1000

Podcast: LAS NOTICIAS CON CALLE DE 12 DE JUNIO DE 2025 - LUMA responde a guerra, asegura que en sus cuentas le deben casi mil millones, Czar de energía dice que es falso - T11 - Irán e Israel a punto de guerra tras colapsar negociaciones y Trump pide a familias empezar a salir de zona - FT- Católica compra UCB en más cambios de centros educativos a punto de cerrar - El Nuevo Día - Vienen más APP - El Vocero - Gobierno anuncia programa con bancos para que jóvenes compren casas, los bancos y cooperativas no saben nada - El Vocero- Cada vez más viejos los padres boricuas - Metro - A sobre 300 mil la vivienda de interés social en PR - Primera Hora- Tras caso de intento de violación de sujeto liberado tras violar enmendarán la ley - El Nuevo Día- Madres indocumentadas están autorizando custodias para evitar que sus hijos pierdan al deportarles a ellas - El Nuevo Día - Crearán albergue de mascotas en edificio abandonado de PRIDCO para municipios - El Nuevo Día - JGo dice que no dará info de menores en casos de deportación a menos que haya orden judicial - El Nuevo Día- Enfermeros en protesta hoy - El Nuevo Día - Se le cae caso a federales, libre de todo Velázquez Piñol aunque pudieran volver a acusarlo - El Vocero - Serpientes no son un emergencia dice Recursos Naturales - El Vocero - Trump vuelve con las benditas tarifas en dos semanas informó - FT- Senadores plantean empuje de resistencia contra el proyecto de Trump y su presupuesto - FT- Sale propuesta para resolver tranque republicano cortándole poder al FED - Bloomberg - Inversionistas huyen al oro ante incertidumbre de mercados y Euro pasa a tercer plano - Financial Times - Socavón en Rexville con camión de basusra - Noticentro - Se estrella avión en India poco después de despegar - India Times Siempre innovando y con los mejores beneficios, MCS PersonalDirecto te ofrece cubiertas accesibles para que cuides de tu salud y la de los tuyos.Con una amplia red de proveedores de más de 15,000 médicos de libre selección.Reembolso de hasta $40 mensuales por membresía a un gimnasio o por un entrenadorpersonal debidamente certificado. Asistencia en el hogar para servicios de cerrajería,plomería y electricidad de hasta $350 por evento hasta 4 veces al año.¡Únete HOY a la gran familia de MCS!¡Salud que completa tu vida! Llama al 787.945.1259 y oriéntate.

This week Mackenzie and Hanna invite the first PI guest on the show to share one of their own stories! The first PI guest is Austin, a nine-year veteran whose toolkit spans family-law digs, criminal-defense surveillance, insurance-fraud exposés and cutting-edge open-source sleuthing. He pulls back the curtain on what it really takes to trail a suspect—long hours in a lobby, split-second decisions on whether to dash inside or stay hidden, and even the pros and cons of facial-recognition software like PIMeyes. You'll get Austin's top safety hacks for vetting dates (free and low-cost background-check resources you can use tonight) and discover why a seemingly innocent Memorial Day beach trip ended with an all-too-public, trunk-wide rendezvous in a cherry-red Porsche.Click here to join our Patreon! For only $5 a month you will get 2 extra episodes a month, monthly virtual live events, and access to our community page. And now for $9 a month you can get all of that, plus ad free episodes!If you've been dogfished and want to share your story on the show, email investigate@thedatingdetectivespodcast.com or contact us through our website using this linkTake control of your data today. Get 20% off your DeleteMe plan by visiting joindeleteme.com/datingdetectives and using the promo code TDD at checkout. This episode of The Dating Detectives is sponsored by Simpli Pop. Find your favorite new prebiotic soda at CokeURL.com/SimplyPop.***The following Program contains names, places and events that have been anonymized or fictionalized for the purposes of protection and safety. The following Program is provided for entertainment purposes only and any commentary from the hosts are strictly conjecture and should not be held as making any definitive statements about the truth or identity of any particular individuals or circumstances.If you or a loved one are involved in an abusive relationship, please call the National Domestic Violence Hotline at 1-800-799-7233 for support.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.