Podcasts about Pi

1-Striscia di Gaza. La fame è usata come arma di guerra. Il giornale Haaretz dà la parola ai soldati israeliani. Le testimonianze raccolte confermano le denunce delle Ong. ( Martina Stefanoni) 2-Nucleare iraniano: Donald Trump gioca la carta degli incentivi per rilanciare i negoziati. ( Nima Bahlevi, Alfredo Somoza) 3-Gran Bretagna. Più welfare meno armi. Il premier Starmer fa marcia indietro sui tagli ai sussidi dopo la rivolta dei deputati laburisti. ( Daniele Fisichella) 4-Allarme disuguaglianza. Negli ultimi dieci anni la ricchezza dell'1% più ricco è aumentata di circa 34 mila dollari. Il rapporto Oxfam alla vigilia della Conferenza sul finanziamento dello sviluppo di Siviglia. ( Giulio Maria Piantadosi) 5-Cervelli in fuga dall'oscurantismo. Marsiglia ha accolto ieri primi ricercatori americani. ( Francesco Giorgini) 6-Massive Attack. Concerti oltre i confini della musica. La recensione di Pier Giorgio Pardo.

Rēzeknis vaļstspiļsātā dzeivoj drupeit vaira nakai 26 000 dzeivuotuoju. Piļsātā, kur bezdorbs sasnādz 7,2% nu dorba spiejeigū cylvāku, i struodojūšū cylvāku videjuo olga ir tikai 1165 eiro, pyrma goda tyka atlaista piļsātys dūme i ar lykumu īcalta pagaidu administraceja. Īmeslis ir īprīkšejuos politiskuos varys naspieja sabalansēt budžetu, īleinūt miļzeigūs poruodūs, kū piļsāta vaira navarēja paceļt. I pagaidu administracejai tys beja juosakuortoj goda laikā da nuokušajom vieliešonom, voi vysmoz juostabilizej situaceja, kab piļsāta naītu bankrotā. Ir paguojs gods, nūtykušys ari pošvaļdeibu vieliešonys. Rēzeknīši otkon ir izdarejuši sovu izvēli par lobu tam pošam politiskajam spākam “Kūpā Latvejai” i tuo vadeituojam Aleksandram Bartaševičam, kurs ari pyrma tam tyka atlaists. Kas pa godu pagaidu administracejai ir izadevs, i kaidi ir secynuojumi par ūtrys leluokuos Latgolys vaļstspiļsātys Rēzeknis nuokūtnis atteisteibys perspektivom, par tū saruna ar nu jau bejušū Rēzeknis pagaidu administracejis vadeituoju Gunu Puci.

Nonprofits - how do YOU communicate about the dreaded “overhead” expenses? You know that pie chart everyone uses to show how much money goes directly to programs? Yeah, I want to toss it out the window. We'll talk about why those “eight cents” on the dollar that cover essential administrative expenses are not wasted but actually crucial for keeping your nonprofit running smoothly. In this episode, we're tackling a nonprofit pro's question about updating an employee handbook. Should you hire a pro bono lawyer who DOESN'T do employment law or invest in an HR expert? Spoiler alert: Your uncle Larry, the PI lawyer, might not be the best fit here. It's all about making smart investments in your nonprofit's operations and HR to avoid headaches down the line. Trust me, you'll thank yourself later when you don't end up in a legal pickle. So, grab your headphones and join us for a lively chat about transforming how nonprofits communicate their spending to donors. We promise some laughs, a few rants, and a whole lot of practical advice. And remember, it's okay to spend money on things that keep your nonprofit running well! Let's rethink the way we tell our financial stories and embrace the true costs of running an amazing organization. In this episode, you will hear: Why you need to delete that outdated nonprofit overhead pie chart Whether pro bono is the right way to go with your employment law needs Some of our recommendations for tools to keep up with all the changing HR rules The real relationship between the back-office and your direct mission programming How you can REALLY communicate success to your donors What your fiduciary duties really have to do with all our worries about “overhead” Resources from this Episode Propel Article - A Graphic Re-Visioning of Nonprofit Overhead: https://propelnonprofits.org/blog/a-graphic-re-visioning-of-nonprofit-overhead/ The Five Whys: https://en.wikipedia.org/wiki/Five_whys Sign up for the Birken Law Email list: https://birkenlaw.com/signup/ Facebook page: https://www.facebook.com/birkenlaw Follow and Review: We'd love for you to follow us if you haven't yet. Click that purple '+' in the top right corner of your Apple Podcasts app. We'd love it even more if you could drop a review or 5-star rating over on Apple Podcasts. Simply select “Ratings and Reviews” and “Write a Review” then a quick line with your favorite part of the episode. It only takes a second and it helps spread the word about the podcast. Episode Credits If you like this podcast and are thinking of creating your own, consider talking to my producer, Emerald City Productions. They helped me grow and produce the podcast you are listening to right now. Find out more at https://emeraldcitypro.com Let them know we sent you.

UTP372 Chillout filosófico ………………………………………………………………………………………. Conductor del programa UTP Ramón Valero @tecn_preocupado Canal en Telegram @UnTecnicoPreocupado Un técnico Preocupado un FP2 IVOOX UTP http://cutt.ly/dzhhGrf BLOG http://cutt.ly/dzhh2LX Ayúdame desde mi Crowfunding aquí https://cutt.ly/W0DsPVq Invitados Dra Yane #JusticiaParaUTP @ayec98_2 Médico y Buscadora de la verdad. Con Dios siempre! No permito q me dividan c/izq -derecha, raza, religión ni nada de la Creación. https://youtu.be/TXEEZUYd4c0 …. losvengadores3 @Vengadores33 SOΨ ραrτε δε lα GΓλΠ MΣΠΤΣ CΓΣλDOΓλ LA CLASE POLÍTICACA DEBE SER DESINTEGRADA% onu NO ESTAMOS JUGANDO …. Nunkálo Zabras @Nklo_Zabras ALL WAYS WHAT XING …. Fernando Beltrán @nenucosinpanial @venusmelibra ………………………………………………………………………………………. Enlaces citados en el podcast: AYUDA A TRAVÉS DE LA COMPRA DE MIS LIBROS https://tecnicopreocupado.com/2024/11/16/ayuda-a-traves-de-la-compra-de-mis-libros/ ………………………………………………………………………………………. Música utilizada en este podcast: Tema inicial Heros Epílogo Con$pirazion - semillas https://youtu.be/7Yxwvf8nG6I?feature=shared

A Badalona, la Fundació Llegat Roca i Pi fa gairebé 150 anys que treballa per acompanyar persones en situació de vulnerabilitat. Amb una mirada arrelada al territori i una acció social que combina habitatge digne, inserció laboral i suport emocional, la fundació ha esdevingut un referent en la lluita contra l'exclusió social. En parlem amb Mar Alsamora, cap d'Acció Social de Roca i Pi. podcast recorded with enacast.com

Supio, an AI-driven platform developed specifically for personal injury lawyers, has been generating a lot of buzz. On the heels of reporting record growth last year and raising $25 million in Series A funding in October, last month it raised another $60 million in a Series B round. But what do the lawyers who use the platform think of it? On today's LawNext, we hear from one of those lawyers, as well as from the company's cofounder and CEO. Our guests today are:   Tyler Schneider, managing partner of the personal injury law firm TorHoerman Law. Schneider was an early adopter of Supio. He and his firm used it to help obtain a $495 million verdict against Abbott Labs in a case involving allegations that cow's milk-based infant formula caused intestinal inflammation in premature babies. Jerry Zhou, the CEO of Supio who cofounded it in 2021 together with his childhood friend and coworker Kyle Lam after having held product management and engineering roles at Microsoft and Avalara.    In their conversation with host Bob Ambrogi, Zhou and Schneider talk about the development of Supio, its real-world impact on plaintiffs' lawyers, and their wish lists for further development of the product. They also share their thoughts on how AI is likely to reshape PI practice more broadly.    Thank You To Our Sponsors This episode of LawNext is generously made possible by our sponsors. We appreciate their support and hope you will check them out. Paradigm, home to the practice management platforms PracticePanther, Bill4Time, MerusCase and LollyLaw; the e-payments platform Headnote; and the legal accounting software TrustBooks. Briefpoint, eliminating routine discovery response and request drafting tasks so you can focus on drafting what matters (or just make it home for dinner). SpeakWrite: Save time with fast, human-powered legal transcription—so you can focus on your practice   If you enjoy listening to LawNext, please leave us a review wherever you listen to podcasts.  

Silêman Zandînan tev malbata xwe, di sala 2018an de gihîştin Australya. Ji zarokatiya xwe ve hewesa wî ji bo futbolê heye. Piştî kutakirina korsê hekemiyê, ew niha di Queensland FQPL1 û FQPL2 de, ku duyemîn asta herî bilind a futbolê li Queensland temsîl dikin, hekemiyê dike. Silêman dixwaze rojekê ji bo tîmê neteweyî yê futbola Australyayê hekemiyê bike.

What universal truths do you believe in? This week, Joey and Jess talk about database shapes, LLMs, collective human intelligence, apple eating, folk wisdom, and Pi. They don't talk about apple pie, though. references West End Girls Ethan Mollic on the "universal geometry" of meaning The Platonic Representation Hypothesis Doctor Dillamond's Classroom Algospeak: How Social Media is Transforming the Future of Language Study: Association Between Apple Consumption and Physician Visits Honeycrisp apples 

Dr. Allison Zibelli and Dr. Rebecca Shatsky discuss advances in breast cancer research that were presented at the 2025 ASCO Annual Meeting, including a potential new standard of care for HER2+ breast cancer, the future of ER+ breast cancer management, and innovations in triple negative breast cancer therapy. Transcript Dr. Allison Zibelli: Hello and welcome to the ASCO Daily News Podcast. I'm Dr. Allison Zibelli, your guest host of the podcast today. I'm an associate professor of medicine and a breast medical oncologist at the Sidney Kimmel Comprehensive Cancer Center at Jefferson Health. There was a substantial amount of exciting breast cancer data presented at the 2025 ASCO Annual Meeting, and I'm delighted to be joined by Dr. Rebecca Shatsky today to discuss some of these key advancements. Dr. Shatsky is an associate professor of medicine at UC San Diego and the head of breast medical oncology at the UC San Diego Health Moores Cancer Center, where she also serves as the director of the Breast Cancer Clinical Trials Program and the Inflammatory and Triple-Negative Breast Cancer Program.  Our full disclosures are available in the transcript of this episode. Dr. Shatsky, it's great to have you on the podcast today. Dr. Rebecca Shatsky: Thanks, Dr. Zibelli. It's wonderful to be here. Dr. Allison Zibelli: So, we're starting with DESTINY-Breast09, which was trastuzumab deruxtecan and pertuzumab versus our more standard regimen of taxane, trastuzumab pertuzumab for first-line treatment of metastatic HER2-positive breast cancer. Could you tell us a little bit about the study? Dr. Rebecca Shatsky: Yeah, absolutely. So, this was a long-awaited study. When T-DXd, or trastuzumab deruxtecan, really hit the market, a lot of these DESTINY-Breast trials were started around the same time. Now, this was a global, randomized, phase 3 study presented by Dr. Sara Tolaney from the Dana-Farber Cancer Institute of Harvard in Boston. It was assessing essentially T-DXd in the first-line setting for metastatic HER2-positive breast cancer in addition to pertuzumab. And that was randomized against our standard-of-care regimen, which was established over a decade ago by the CLEOPATRA trial, and we've all been using that internationally for at least the past 10 years. So, this was a large trial, and it was one-to-one-to-one of patients getting T-DXd plus pertuzumab, T-DXd alone, or THP, which mostly is used as docetaxel and trastuzumab and pertuzumab every three weeks for six cycles. And this was in over 1,000 patients; it was 1,159 patients with metastatic HER2-positive breast cancer. This was a very interesting trial. It was looking at the use of trastuzumab deruxtecan, but patients were started on this treatment for their first-line metastatic HER2-positive breast cancer with no end date to their T-DXd. So, it was, you know, you were started on T-DXd every 3 weeks until progression. Now, CLEOPATRA is a little bit different than that, though, as we know. So, CLEOPATRA has a taxane plus trastuzumab and pertuzumab. But generally, patients drop the taxane after about six to seven cycles because, as we know, you can't be really on a taxane indefinitely. You get pretty substantial neuropathy as well as cytopenias, other things that end up happening. And so, in general, that regimen has sort of a limited time course for its chemotherapy portion, and the patients maintained after the taxane is dropped on their trastuzumab and their pertuzumab, plus or minus endocrine therapy if the investigator so desires. And the primary endpoint of the trial was progression-free survival by blinded, independent central review (BICR) in the intent-to-treat population. And then it had its other endpoints as overall survival, investigator-assessed progression-free survival, objective response rates, and duration of response, and of course, safety. As far as the results of this trial, so, I think that most of us key opinion leaders in breast oncology were expecting that this was going to be a positive trial. And it surely was. I mean, this is a really, really active drug, especially in HER2-positive disease, of course. So, the DESTINY-Breast03 data really established that, that this is a very effective treatment in HER2-positive metastatic breast cancer. And this trial really, again, showed that. So, there were 383 patients that ended up on the trastuzumab plus deruxtecan plus pertuzumab arm, and 387 got THP, the CLEOPATRA regimen. What was really interesting also to note of this before I go on to the results was that 52% of patients on this trial had de novo metastatic disease. And that's pretty unusual for any kind of metastatic breast cancer trial. It kind of shows you, though, just how aggressive this disease is, that a lot of patients, they present with de novo metastatic disease. It's also reflecting the global nature of this trial where maybe the screening efforts are a little bit less than maybe in the United States, and more patients are presenting as later stage because to have a metastatic breast cancer trial in the United States with 52% de novo metastatic disease doesn't usually happen. But regardless, the disease characteristics were pretty well matched between the two groups. 54% of the patients were triple positive, or you could say hormone-positive because whether they were PR positive or ER positive and PR negative doesn't really matter in this disease. And so, the interim data cutoff was February of this year, of 2025. So, the follow-up so far has been about 29 months, so the data is still really immature, only 38% mature for progression-free survival interim analysis. But what we saw is that T-DXd plus pertuzumab, it really improved progression-free survival. It had a hazard ratio that was pretty phenomenal at 0.56 with a confidence interval that was pretty narrow of 0.44 to 0.71. So, very highly statistically significant data here. The progression-free survival was consistent across all subgroups. Overall survival, very much immature at this time, but of course, the trend is towards an overall survival benefit for the T-DXd group. The median durable response with T-DXd plus pertuzumab exceeded 3 years. Now, importantly, though, I want to stress this, is grade 3 or above treatment-emergent adverse events occurred in both subgroups pretty equally. But there were 2 deaths in the T-DXd group due to interstitial lung disease. And there was a 12.1% adjudicated drug-induced interstitial lung disease/pneumonitis event rate in the T-DXd group and only 1%, and it was grade 1-2, in the THP group. So, that's really the caveat of this therapy, is we know that a percentage of patients are going to get interstitial lung disease, and that some may have very serious adverse events from it. So, that's always something I keep in the back of my mind when I treat patients with T-DXd. And so, overall, the conclusions of the trial were pretty much a slam dunk. T-DXd plus pertuzumab, it had a highly statistically significant and clinically meaningful improvement in progression-free survival versus the CLEOPATRA regimen. And that was across all subgroups for first-line metastatic HER2-positive breast cancer here. And so, yeah, the data was pretty impressive. Just to go into the overall response rate, because that's always super important as well, you had 85.1% of patients having a confirmed overall RECIST response rate in the T-DXd plus pertuzumab group and a 78.6 in the CLEOPATRA group. The complete CR rate, complete response was 15.1% in the T-DXd group and 8.5 in the CLEOPATRA regimen. And it was really an effective regimen in this group, of course. Dr. Allison Zibelli: So, the investigators say at the end of their abstract that this is the new standard of care. Would you agree with that statement? Dr. Rebecca Shatsky: Yeah, that was a bold statement to make because I would say in the United States, not necessarily at the moment because the quality of life here, you have to think really hard about. Because one thing that's really important about the DESTINY-Breast09 data is that this was very much an international trial, and in many of the countries where patients enrolled on this, they were not able to access T-DXd off trial. And so, for them, this means T-DXd now or potentially never. And so, that is a really big difference whereas internationally, that may mean standard of care. However, in the US, patients have no issues accessing T-DXd in the second- or third-line settings. And right now, it's the standard of care in the second line in the United States, with all patients basically getting this second-line therapy except for some unique patients where they may be doing a PATINA trial regimen, which we saw at San Antonio Breast Cancer in 2024 of the triple-positive patients getting hormonal therapy plus palbociclib, which had a really great durable response. That was super impressive as well. Or there is the patient that the investigator can pick KADCYLA because the patient really wants to preserve their hair or maybe it's more indolent disease. But the quality of life on T-DXd indefinitely in the first-line setting is a big deal because, again, that CLEOPATRA regimen allows patients to drop their chemotherapy component about five to six months in. And with this, you're on a drug that feels very chemo-heavy indefinitely. And so, I think there's a lot more to investigate as far as what we're going to do with this data in the United States because it's a lot to commit a patient in the first-line metastatic setting. These de novo metastatic patients, some of them may be cured, honestly, on the HER2-targeting regimen. That's something we see these days. Dr. Allison Zibelli: So, very interesting trial. I'm sure we'll be talking about this for a long time.  So, let's move on to SERENA-6, which was, I thought, a very interesting trial. This trial took patients with ER positive, advanced breast cancer after six months on an AI (aromatase inhibitor) and a CDK4/6 inhibitor. They did ctDNA every two to three months, and when they saw an ESR1 mutation emerge, they changed half of the patients to camizestrant plus CDK4/6 and kept the other half on the AI plus CDK4/6. Can you talk about that trial a little bit, please? Dr. Rebecca Shatsky: Yeah, so this was a big trial at ASCO25. This was presented as a Plenary Session. So, this was camizestrant plus a CDK4/6 inhibitor, and it could have been any of the three, so palbo, ribo, or abemaciclib in the first-line metastatic hormone-positive population, and patients were on an AI with that. They were, interestingly, tested by ctDNA at baseline to see if they had an ESR1 mutation. So, that was an interesting feature of this trial. But patients had to have already been on their CDK4/6 inhibitor plus AI for at least 6 months to enroll. And then, as you mentioned, they got ctDNA testing every 2 to 3 months. This was also a phase 3, double-blind, international trial. And I do want to highlight again, international here, because that's important when we're considering some of this data in the U.S. because it influences some of the results. So, this was presented by Dr. Nick Turner of the Royal Marsden in the UK. So, just a little bit of background for our listeners on ESR1 mutations and why they're important. This is the most common, basically, acquired resistance mutation to patients being treated with aromatase inhibitors. We know that treatment with aromatase inhibitors can induce this. It makes a conformational change in the estrogen receptor that makes the estrogen receptor constitutively active, which allows the cell to signal despite the influence of the aromatase inhibitor to decrease the estrogen production so that the ligand binding doesn't matter as much as far as the cell signaling and transcription is concerned. And camizestrant, you know, as an oral SERD, just to explain that a little bit too; these are estrogen receptor degraders. The first-in-class of a selective estrogen receptor degrader to make it to market was fulvestrant. And that's really been our standard-of-care estrogen degrader for the past 25 years, almost 25 years. And so, a lot of us are just looking for some of these oral SERDs to replace that. But regardless, they do tend to work in the ESR1-mutated population. And we know that patients on aromatase inhibitors, the estimates of patients developing an ESR1 mutation, depending on which study you look at, somewhere between 30% to 50% overall, patients will develop this mutation with hormone-positive metastatic breast cancer. There is a small percentage of patients that have these at baseline without even treatment of an aromatase inhibitor. The estimates of that are somewhere between 0.5 and up to 5%, depending on the trial you look at and the population. But regardless, there is a chance someone on their CDK4/6 inhibitor plus AI at 6 months' time course could have had an ESR1 mutation at that time. But anyway, so they got this ctDNA every 2 to 3 months, and once they were found to develop an ESR1 mutation, the patients were then switched to the oral SERD. AstraZeneca's version of the oral SERD is camizestrant, 75 mg daily. And then their type of CDK4/6 inhibitor was maintained, so they didn't switch the brand of their CDK4/6 inhibitor, importantly. And that was looked at then for progression-free survival, but these were patients with measurable disease by RECIST version 1.1. And the data cut off here was November of 2024. This was a big trial, you know, and I think that that's influential here because this was 3,256 patients, and that's a lot of patients. So, they were all eligible. And then 315 patients ended up being randomized to switch to camizestrant upon presence of that ESR1 mutation. So, that was 157 patients. And then the other half, so they were randomized 1:1, they continued on their AI without switching to an oral SERD. That was 158 patients. They were matched pretty well. And so, their baseline characteristics, you know, the two subgroups was good. But this was highly statistically significant data. I'm not going to diminish that in any way. Your hazard ratio was 0.44. Highly statistically significant confidence intervals. And you had a median progression-free survival in those that switched to camizestrant of 16 months, and then the non-switchers was 9.2 months. So, the progression-free survival benefit there was also consistent across the subgroups. And so, you had at 12 months, the PFS rate was 60.7% for the non-treatment group and 33.4% in the treatment group. What's interesting, though, is we don't have overall survival data. This is really immature, only 12% mature as far as overall survival. And again, because this was an international trial and patients in other countries right now do not have the access to oral SERDs that the United States does, the crossover rate, they were not allowed to crossover, and so, a very few patients, when we look at progression-free survival 2 and ultimately overall survival, were able to access an oral SERD in the off-trial here and in the non-treatment group. And so, that's really important as far as we look at these results. Adverse events were pretty minimal. These are very safe drugs, camizestrant and all the other oral SERDs. They have some mild toxicities. Camizestrant is known for something weird, which is called photopsia, which is some flashing lights in the periphery of the eye, but it doesn't seem to have any serious clinical significance that we know of. It has a little bit of bradycardia, but it's otherwise really well tolerated. You know, I hate to say that because that's very subjective, right? I'm not the one taking the drug. But it doesn't have any serious adverse events that would cause discontinuation. And that's really what we saw in the trial. The discontinuation rates were really low. But overall, I mean, this was a positive trial. SERENA-6 showed that switching to camizestrant at the first sign of an ESR1 mutation on CDK4/6 inhibitor plus AI improved progression-free survival. That's all we can really say from it right now. Dr. Allison Zibelli: So, let's move on to ASCENT-04, which was a bit more straightforward. Sacituzumab govitecan plus pembrolizumab versus chemotherapy plus pembrolizumab in PD-L1-positive, triple-negative breast cancer. Could you talk about that study? Dr. Rebecca Shatsky: Yeah, so this was also presented by the lovely Sara Tolaney from Dana-Farber. And this study made me really excited. And maybe that's because I'm a triple-negative breast cancer person. I mean, not to say that I don't treat hundreds of patients with hormone- positive, but our unmet needs in triple negative are huge because this is a disease where you have got to throw your best available therapy at it as soon as you can to improve survival because survival is so poor in this disease. The average survival with metastatic triple-negative breast cancer in the United States is still 13-18 months, and that's terrible. And so, for full disclosure, I did have this trial open at my site. I was one of the site PIs. I'm not the global PI of the study, obviously. So, what this study was was for patients who had had at least a progression-free survival of 6 months after their curative intent therapy or de novo metastatic disease. They were PD-L1 positive as assessed by the Dako 22C3 assay of greater than or equal to a CPS score of 10. So, that's what the KEYNOTE-355 trial was based on as well. So, standard definition of PD-L1 positive in breast cancer here. And basically, these patients were randomized 1:1 to either their sacituzumab govitecan plus pembrolizumab, day 1 they got both therapies, and then day 8 just the saci, as is standard for sacituzumab. And then the other group got the KEYNOTE-355 regimen. So, that is pembrolizumab with – your options are carbogem there, paclitaxel or nab-paclitaxel. And it's up to investigator's decision which upon those they decided. They followed these patients for disease progression or unacceptable toxicity. It was really an impressive trial in my opinion because we know already that this didn't just improve progression-free survival, because survival is so poor in this disease, of course, we know that it improved overall survival. It's trending towards that very much, and I think that's going to be shown immediately. And then the objective response rates were better, which is key in this disease because in the first-line setting, you've got a lot of people who, especially your relapsed TNBC that don't respond to anything. And you lose a ton of patients even in the first-line setting in this disease. And so, this was 222 patients to chemotherapy and pembro and 221 to sacituzumab plus pembro. Median follow-up has only been 14 months, so it's still super early here. Hazard ratio so far of progression-free survival is 0.65, highly statistically significant, narrow confidence intervals. And so, the median duration of response here for the saci group was 16.5 months versus 9.2 months. So, you're getting a 7-month progression-free survival benefit here, which in triple negative is pretty fantastic. I mean, this reminds me of when we saw the ASCENT data originally come out for sacituzumab, and we were all just so happy that we had this tool now that doubled progression-free and overall survival and made such a difference in this really horrible disease where patients do poorly. So, OS is technically immature here, but it's really trending very heavily towards improvement in overall survival. Importantly, the treatment-related adverse events in this, I mean, we know sacituzumab causes neutropenia, people who are experienced with this drug know how to manage it at this point. There wasn't any really unexpected treatment-related adverse events. You get some people with sacituzumab who have diarrhea. It's usually pretty manageable with some Imodium. So, it was cytopenias predominantly in this disease in this population that were highlighted as far as adverse events. But I'm going to be honest, like I was surprised that this wasn't the plenary over the SERENA-6 data because this, in my mind, there we have a practice-changing trial. I will immediately be trying to use this in my PD-L1 population because, to be honest, as a triple-negative breast cancer clinical specialist, when I get a patient with metastatic triple-negative breast cancer who's PD-L1 positive, I think, "Oh, thank God," because we know that part of the disease just does better in general. But now I have something that really could give them a durable response for much longer than I ever thought possible when I started really heavily treating this disease. And so, this was immediately practice-changing for me. Dr. Allison Zibelli: I think that it's pretty clear that this is at least an option, if not the option, for this group of patients. Dr. Rebecca Shatsky: Yeah, the duration of responses here was – it's just really important because, I mean, I do think this will make people live longer. Dr. Allison Zibelli: So, moving on to the final study that we're going to discuss today, neoCARHP (LBA500), which was neoadjuvant taxane plus trastuzumab, pertuzumab, plus or minus carbo(platin) in HER2-positive early breast cancer. I think this is a study a lot of us have been waiting for. What was the design and the results of this trial? Dr. Rebecca Shatsky: I was really excited about this as well because I'm one of those people that was waiting for this. This is a Chinese trial, so that is something to take note of. It wasn't an international trial, but it was a de-escalation trial which had become really popular in HER2-positive therapy because we know that we're overtreating HER2-positive breast cancer in a lot of patients. A lot of patients we're throwing the kitchen sink at it when maybe that is not necessary, and we can really de-escalate and try to personalize therapy a little bit better because these patients tend to do well. So, the standard of care, of course, in HER2-positive curative intent breast cancer with tumors that are greater than 2 cm is to give them the TCHP regimen, which is docetaxel, carboplatin, trastuzumab, and pertuzumab. And that was sort of established by several trials in the NeoSphere trial, and now it's been repeated in a lot of different studies as well. And so, that's really the standard of care that most people in the United States use for HER2-positive curative intent breast cancer. This was a trial to de-escalate the carboplatin, which I was super excited about because many of us who treat this disease a lot think carbo is the least important part of the therapy you're giving there. We don't really know that it's necessary. We've just been doing it for a long time, and we know that it adds a significant amount of toxicity. It causes thrombocytopenia, it causes severe nausea, really bad cytopenias that can be difficult in the last few cycles of this to manage. So, this trial was created. It randomized patients one to one with stage 2 and 3 HER2-positive breast cancer to either get THP, a taxane, pertuzumab, trastuzumab, similar to the what we do in first-line metastatic HER2-positive versus the whole TCHP with a carboplatin AUC of 6, which is what's pretty standard. And it was a non-inferiority trial, so important there. It wasn't to establish superiority of this regimen, which none of us, I think, were looking for it to. And it was a modified intent-to-treat population. And so, all patients got at least one cycle of this to be assessed as a standard for an intent-to-treat trial. And so, they assumed a pCR rate of about 62.8% for both groups. And, of course, it included both HER2-positive triple positives and ER negatives, which are, you know, a bit different diseases, to be honest, but we all kind of categorize them and treat them the same. And so, this trial was powered appropriately to detect a non-inferiority difference. And so, we had about 380 patients treated on both arms, and there was an absolute difference of only 1.8% of those treated with carbo versus those without. Which was fantastic because you really realized that de-escalation here may be something we can really do. And so, the patients who got, of course, the taxane regimen had fewer adverse events. They had way fewer grade 3 and 4 adverse events than the THP group. No treatment-associated deaths occur, which is pretty standard for- this is a pretty safe regimen, but it causes a lot of hospitalizations due to diarrhea, due to cytopenias, and neutropenic fever, of course. And so, I thought that this was something that I could potentially enact, you know, and be practice-changing. It's hard to say that when it's a trial that was only done in China, so it's not necessarily the United States population always. But I think for patients moving forward, especially those with, say, a 2.5 cm tumor, you know, node negative, those, I'd feel pretty comfortable not giving them the carboplatin here. Notes that I want to make about this population is that the majority were stage 2 and not stage 3. They weren't necessarily your inflammatory HER2-positive breast cancer patients. And that the taxane that was utilized in the trial is a little different than what we use in the United States. The patients were allowed to get nab-paclitaxel, which we don't have FDA approval for in the first-line curative intent setting for HER2-positive breast cancer in the United States. So, a lot of them got abraxane, and then they also got paclitaxel. We tend to use docetaxel every 3 weeks in the United States. So, just to point out that difference. We don't really know if that's important or not, but it's just a little bit different to the population we standardly treat. Dr. Allison Zibelli: So, are there patients that you would still give TCHP to? Dr. Rebecca Shatsky: Yeah, great question. I've been asked that a lot in the past like week since ASCO. I'd say in my inflammatory breast cancer patients, that's a group I do tend to sometimes throw the kitchen sink at. Now, I don't actually use AC in those because I know that that was the concern, but I think the TRAIN-2 trial really showed us you don't need to use Adriamycin in HER2-positive disease unless it's like refractory. So, I don't know that I would throw this on my stage 3C or inflammatory breast cancer patients yet because the majority of this were not stage 3. So, in your really highly lymph node positive patients, I'm a little bit hesitant to de-escalate them from the start. This is more of a like, if there's serious toxicity concerns, dropping carbo is absolutely fine here. Dr. Allison Zibelli: All right, great.  Thank you, Dr. Shatsky, for sharing your valuable insights with us on the ASCO Daily News Podcast today. Dr. Rebecca Shatsky: Thanks so much, Dr. Zibelli and ASCO Daily News. I really want to thank you for inviting me to talk about this today. It was really fun, and I hope you find my opinions on some of this valuable. And so, I just want to thank everybody and my listeners as well. Dr. Allison Zibelli: And thank you to our listeners for joining us today. You'll find the links to all the abstracts discussed today in the transcript of this episode. Finally, if you like this podcast and you learn things from it, please take a moment to rate, review, and describe because it helps other people find us wherever you get your podcasts. Thank you again. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. More on today's speakers Dr. Allison Zibelli Dr. Rebecca Shatsky @Dr_RShatsky Follow ASCO on social media:  @ASCO on Twitter  @ASCO on Bluesky  ASCO on Facebook  ASCO on LinkedIn   Disclosures: Dr. Allison Zibelli: No relationships to disclose Dr. Rebecca Shatsky: Consulting or Advisory Role: Stemline, Astra Zeneca, Endeavor BioMedicines, Lilly, Novartis, TEMPUS, Guardant Health, Daiichi Sankyo/Astra Zeneca, Pfizer Research Funding (Inst.): OBI Pharma, Astra Zeneca, Greenwich LifeSciences, Briacell, Gilead, OnKure, QuantumLeap Health, Stemline Therapeutics, Regor Therapeutics, Greenwich LifeSciences, Alterome Therapeutics  

Two weeks ago, our paid subscribers got exclusive early access to one of our most compelling interviews yet.Today, it's your turn.We're proud to release our full conversation with Alex R. Johnson—a filmmaker whose debut novel is making serious waves. If you love gritty stories, complex characters, or the electric pulse of New York noir, this is the interview for you.

JURASSIC WORLD GOES FULL MONSTER MOVIE!! Jurassic World: Fallen Kingdom Start your online business with a $1 per-month trial when you visit https://www.shopify.com/rejects! Jurassic World embraces full-on Monster Movie Camp!! Jurassic World: Fallen Kingdom Reaction, Recap, Commentary, Analysis, & Spoiler Review!! Greg Alba & Tara Erickson return to Isla Nublar (and beyond!) in their latest Reaction & Review of Jurassic World: Fallen Kingdom, the 2018 action-packed sequel directed by J.A. Bayona (The Impossible, A Monster Calls) and written by Colin Trevorrow & Derek Connolly. This fifth installment in the Jurassic Park franchise blends sci-fi spectacle with horror-thriller tension as dinosaurs once again roam where they shouldn't—and humanity pays the price. Chris Pratt (Guardians of the Galaxy, The Super Mario Bros. Movie) reprises his role as raptor trainer Owen Grady, teaming up with Bryce Dallas Howard (The Help, Rocketman) as Claire Dearing, now an activist fighting to rescue the dinosaurs from an impending volcanic eruption. They're joined by new allies including Justice Smith (Detective Pikachu, Dungeons & Dragons: Honor Among Thieves) as IT whiz Franklin Webb and Daniella Pineda (The Vampire Diaries, Cowboy Bebop) as paleo-veterinarian Zia Rodriguez. The mission takes a dark turn when they uncover a nefarious plot led by Eli Mills (Rafe Spall – Life of Pi, The Big Short), who plans to auction off the surviving dinosaurs for profit—including the terrifying new hybrid, the Indoraptor. Other cast members include James Cromwell (Babe, L.A. Confidential) as Benjamin Lockwood, B.D. Wong (Mr. Robot, Jurassic Park) returning as Dr. Henry Wu, and Isabella Sermon as Maisie Lockwood, whose shocking origins play a major role in the film's future implications. Iconic moments include the tragic brachiosaurus scene as Isla Nublar erupts, the suspenseful Indoraptor hallway sequence, and the film's climactic release of dinosaurs into the wild—setting the stage for a new world order. With its gothic mansion horror vibes, emotional beats, and dinosaur mayhem, Fallen Kingdom delivers a darker, more morally complex chapter in the saga. Follow Tara Erickson: Youtube: https://www.youtube.com/@TaraErickson Instagram:  https://www.instagram.com/taraerickson/ Twitter:  https://twitter.com/thetaraerickson Intense Suspense by Audionautix is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... Support The Channel By Getting Some REEL REJECTS Apparel! https://www.rejectnationshop.com/ Follow Us On Socials:  Instagram: https://www.instagram.com/reelrejects/  Tik-Tok: https://www.tiktok.com/@reelrejects?lang=en Twitter: https://x.com/reelrejects Facebook: https://www.facebook.com/TheReelRejects/ Music Used In Ad:  Hat the Jazz by Twin Musicom is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Happy Alley by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... POWERED BY @GFUEL Visit https://gfuel.ly/3wD5Ygo and use code REJECTNATION for 20% off select tubs!! Head Editor: https://www.instagram.com/praperhq/?hl=en Co-Editor: Greg Alba Co-Editor: John Humphrey Music In Video: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Ask Us A QUESTION On CAMEO: https://www.cameo.com/thereelrejects Follow TheReelRejects On FACEBOOK, TWITTER, & INSTAGRAM:  FB:  https://www.facebook.com/TheReelRejects/ INSTAGRAM:  https://www.instagram.com/reelrejects/ TWITTER:  https://twitter.com/thereelrejects Follow GREG ON INSTAGRAM & TWITTER: INSTAGRAM:  https://www.instagram.com/thegregalba/ TWITTER:  https://twitter.com/thegregalba Learn more about your ad choices. Visit megaphone.fm/adchoices

Oggi con Matteo e Raffaele facciamo un po' il giro, non tanto dell'Italia, ma delle notizie. Una di queste potrebbe far arrabbiare molto gli studenti al rientro dalla pausa estiva. Trascrizione interattiva e Vocab Helper Support Easy Italian and get interactive transcripts, live vocabulary and bonus content: easyitalian.fm/membership Come scaricare la trascrizione Apri l'episodio in Transcript Player (https://play.easyitalian.fm/episodes/e7e34c2tz24rx7674cub0) Scarica come HTML (https://www.dropbox.com/scl/fi/e7e34c2tz24rx7674cub0/easyitalianpodcast174_transcript.html?rlkey=jnedhmeocmf9bbhxddar19bjd&st=0vyu2d0o&dl=1) Scarica come PDF (https://www.dropbox.com/scl/fi/ygd5waux20l48e42woccj/easyitalianpodcast174_transcript.pdf?rlkey=m54d4pn3d9ev81m4n74rj78da&st=ct3uqpdi&dl=1) Vocabolario Scarica come text file (https://www.dropbox.com/scl/fi/o2eys39fwx9et526k44dp/easyitalianpodcast174_vocab.txt?rlkey=2af4qp3h4n3o5sosqhbhh6j1m&st=is741sm7&dl=1) Scarica come text file with semicolons (https://www.dropbox.com/scl/fi/brz1xeg8ro058kitfbw3p/easyitalianpodcast174_vocab-semicolon.txt?rlkey=215zpcfpiz8u0areqtxphqu51&st=1jwdqp5g&dl=1) (per app che utilizzano flashcard) Iscriviti usando il tuo feed RSS privatoper vedere la trascrizione e il vocab helper subito sulla tua applicazione per ascoltare i podcast sul tuo cellulare. Note dell'episodio What Italians Really Think About Their Politics - https://www.youtube.com/watch?v=BT7IvwSEUHE&t=7s Oggi si inizia dai banchi di scuola. Ma attenzione! Vietati i cellulari! Cosa ne pensate? Matteo e Raffaele ne parlano, e cercano di capire come funzionera'. Ma abbiamo proprio bisogno di avere sempre con noi il cellulare, e soprattutto, serve agli studenti? Il turista anonimo continua a colpire. Questa volta si sono seduti su una sedia. Quindi? Poveri turisti non possono nemmeno riposarsi un attimo tra un monumento ed un altro? Beh certo, possono riposarsi, ma non su una sedia di... Finiamo tutti a mare! Quest'anno le coste italiane sono apparentemente molto pulite, e c'e' una regione che ha vinto per essere la regione con il mare piu' pulito! Curiosi? Vi possiamo dare un indizio: Confina con Campania e Calabria. Indovinato? Trascrizione Raffaele: [0:23] Buongiorno Matteo. Matteo: [0:25] Buongiorno, come va? Raffaele: [0:28] Settimana scorsa avevo il fiatone perché avevo fatto le scale a piedi, attività fisica. Questa settimana ho il fiatone stando fermo. Matteo: [0:39] No, è arrivato il caldo. Raffaele: [0:42] 31 gradi, sopra il 60 per cento di umidità: si suda da fermi, si soffre maledettamente. Matteo: [0:54] Mannaggia. Speriamo che questa cosa non continui. Raffaele: [0:57] Sei andato via giusto in tempo. Il problema che mi pongo io, Matteo, è che se a giugno, a metà giugno, fa così caldo e si soffre così tanto, cosa succede a luglio e agosto? Cioè dove andiamo a finire? Matteo: [1:16] E dove andiamo a finire? Raffaele: [1:18] E pensa che ci sta ancora chi è sui banchi di scuola a studiare con questo caldo. Matteo: [1:29] La vita in Italia in questo momento è calda. Raffaele: [1:32] È molto molto calda. Tu, Matteo, ricordi quando hai fatto l'esame di maturità? La data. Matteo: [1:41] Era giugno, le prime due settimane di giugno. Raffaele: [1:45] Grosso modo di questi tempi. (Sì sì.) Io invece ebbi la sfortuna... il mio cognome inizia con la T, quando si selezionò la lettera per decidere da dove iniziare per fare gli esami orali, giustamente uscì proprio la A. Estratta a sorte la A, e quindi io ero l'ultimo di tutta la classe a fare l'esame. L'ho fatto, se non ricordo male, il 4 luglio. E sono andato a fare l'esame di maturità, non so se te l'ho mai raccontato, col costumino. Cioè il costume e sopra il pantalone: finito l'esame, la prova orale dell'esame di maturità, siamo andati direttamente al mare a festeggiare. Ma si può studiare con questo caldo? Si può stare sui libri a scuola con questo caldo? Matteo: [2:35] No, sicuramente no. Fortunatamente tutte le scuole, a parte gli esami, sono chiuse e riapriranno a settembre. Raffaele: [2:47] Sì, generalmente chiudono intorno al 10 giugno, ma già molto prima ci sono tanti studenti che, finite le interrogazioni, finiti i test, i compiti in classe, come si chiamano, lasciano la scuola generalmente verso la fine di maggio. E ha senso proprio per questo discorso del caldo, considera che non siamo neanche ancora in estate ma già fa così caldo. Quando rientreranno a scuola gli studenti, probabilmente troveranno una novità. Bello o brutta? Non lo so, bisogna chiederlo a loro. Matteo: [3:26] Ah, e che novità troveranno? Poveri studenti, poveri studenti. Raffaele: [3:31] Poveri. A partire da settembre 2025 il cellulare in classe sarà vietato anche agli studenti delle scuole superiori. Matteo: [3:42] E questa è una cosa interessante, è un approccio molto... non dittatoriale, mi sembra un po'... dittatoriale mi sembra troppo, però non me lo aspettavo. Raffaele: [3:55] È un approccio forte, no? È stato fatto l'esperimento con le scuole inferiori, chiamiamole così, quindi le scuole elementari, le scuole medie, e poi adesso si è deciso di espandere questo divieto alle scuole superiori. Alle scuole elementari è stato facilissimo: forse nessun bambino alle scuole elementari ha il cellulare. Anzi mi correggo: io conosco tanti bambini che hanno il cellulare in quarta o quinta elementare ma non lo portano proprio a scuola. Alle medie già comincia ad essere complicato perché un po' tutti hanno il cellulare. Al liceo, alle scuole superiori sarà complicato far rispettare questo divieto. Matteo: [4:44] È una cosa interessante anche perché sto cercando di pensare, cercando di empatizzare il più possibile con i ragazzi e i genitori, per quanto posso ovviamente, e non trovo un motivo per andare contro questa decisione: è giusto che tu non puoi usare il cellulare in classe. Raffaele: [5:12] Eh, siamo sempre nel discorso del libero arbitrio, no? In teoria gli studenti dovrebbero capire che non è il caso di utilizzare il cellulare durante la lezione. Spieghiamo un attimo bene come funziona a partire da settembre: praticamente all'ingresso in classe ci sarà una cassettina oppure si utilizzerà semplicemente il cassetto della cattedra dell'insegnante. E ogni studente che entra in classe, oppure quando entra il professore, i ragazzi devono consegnare il cellulare, mettere il cellulare in questa cassettina o nel cassetto, in modalità non disturbare, di modo che vibrazioni e suonerie non diano fastidio. E recuperare il cellulare in teoria alla fine della giornata ma in pratica quando il professore uscirà di classe, i ragazzi andranno a controllarsi le notifiche, salvo poi rimettere il cellulare a posto quando entra il professore dell'ora successiva. Ha senso così? Cioè alla fine è solo un togliere il cellulare agli alunni durante la lezione? Matteo: [6:27] Allora la questione è che abbiamo a che fare con ragazzi giovani che per una questione anche fisica hanno dei seri problemi a comportarsi in maniera logica. Perché si stanno ancora sviluppando e quindi hanno bisogno di avere a che fare con delle regole e con dei divieti, secondo me. Cioè non puoi basarti sempre e solo sulla logicità, e il ragionamento che dovrebbero fare gli studenti, che sono giovani. Raffaele: [7:14] Eh lo so, ma dirgli proprio "lasciate il cellulare qua, spegnete il cellulare, consegnatelo"... Potresti anche dire "spegnetelo però tenetelo voi, ci fidiamo." Perché poi alla fine è quello un po' il discorso. Tu dici: " Non mi fido." Matteo: [7:28] No, il discorso è proprio quello, il discorso è: si può arrivare a quello dopo una... è un po' come nelle disintossicazioni forti, tu mi insegni... No anche tu, se tu vuoi prendere meno caffè, sei arrivato in una situazione in cui ne stai prendendo tanto, non è che inizi a prenderne di meno. Vai un po' drastico i primi periodi. Raffaele: [7:55] Eh non lo so, non lo so, ci sono diversi approcci, per questo non è così semplice la questione, perché tu dici: il cellulare in classe è un male, quindi la soluzione è togliamo il cellulare. Matteo: [8:11] Ma in realtà il cellulare in classe è un male. Raffaele: [8:14] Dipende da cosa ci fai. Matteo: [8:16] Ma in questo momento lasciando stare il "vorrei che fosse", però se eliminiamo il "come vorrei che fosse la classe ideale oggi", il cellulare e l'uso del cellulare in classe distrae solamente. Raffaele: [8:40] Allora voglio chiarire un po' la mia posizione: io fondamentalmente sono d'accordo con te, nel senso che sono d'accordo che dire ad un tredicenne "tieni il cellulare acceso sul banco durante la lezione" è un invito a nozze per lui. E invece di sentirsi il professore di storia e filosofia, aprirà TikTok e si guarderà i video silenziosamente facendo finta di seguire. Quindi diciamo che è un modo per togliere questa distrazione. Idealmente non sarebbe necessario. Idealmente la lezione dovrebbe essere coinvolgente, e ti dirò di più, dovrebbe trovare un modo per coinvolgere i ragazzi attivamente. E perché non coinvolgere anche con l'uso del cellulare? Cioè per me la scuola dovrebbe andare verso una digitalizzazione massiccia, forte, soprattutto in Italia dove invece su questo siamo un po' indietro. Non ci sono abbastanza computer per tutti gli allievi, non ci sono i tablet per tutti e consentire l'utilizzo del cellulare, in maniera coordinata con l'insegnante eh, attenzione... può essere invece un modo per sopperire a questa mancanza. Idealmente, eh... Matteo: [10:03] Sono d'accordo con te. Idealmente. Ma poi basta che... ricordo le mie lezioni di informatica, e non so se tu hai mai fatto lezioni in aula computer in cui c'erano questi grandi computer, dietro i quali... erano così grandi che ti potevi nascondere dietro il monitor. E lo studente, il suo primo obiettivo quando... non il suo primo obiettivo nel senso che si sveglia e pensa che vuole fare questo.... Ma il cervello ha costanti, dà costanti impulsi per distrarti, sempre. E al primo momento noi, anche senza cellulari, perché entrambi abbiamo fatto i nostri studi durante un periodo in cui non c'era proprio il cellulare... Raffaele: [10:58] Usciva, ti dico la verità, si mandavano gli sms. Matteo: [11:01] Sì, vabbè, però, insomma, era così, non... oltretutto era vietato, non potevi metterti col cellulare sul banco. Raffaele: [11:15] Però mi ricordo che già all'ultimo anno di liceo noi avevamo quasi tutti il cellulare e ci mandavamo i messaggini, quindi già si presentava il problema. Non potevi, chiaro che non potevi, però nessuno ti sequestrava nulla. Matteo: [11:28] Eh no, però la questione è che adesso non solo puoi mandare messaggini ma per esempio puoi compromettere un compito in classe, certo probabilmente ci saranno delle metodologie per i quali se c'è il compito in classe il cellulare viene tolto o comunque viene spento o non lo so. Però già la maggior parte degli studenti è ignorante... Ma buttiamoli proprio i cellulari... Cioè secondo me il cellulare genericamente dovrebbe essere iniziato ad usare a 20 anni, perché crea una serie di problemi. A meno che non si inizi a scuola a fare educazione digitale, che può essere anche fatta con carta e penna, però ti iniziano ad educare a come usare i social, come comportarsi, cosa fare, cosa non fare, cosa evitare. Raffaele: [12:31] E qui convergiamo, Matteo: hai detto una cosa bellissima, esattamente quello che proporrei di fare io, perché il problema secondo me non è la distrazione del cellulare sul banco. Certo le elimini, non hai più la distrazione. Ma non educhi a gestire il cellulare, e secondo me il problema di tanti ragazzi di oggi è proprio quello. Pensa che la proposta successiva di questo governo è: niente social media sotto i 15 anni. E di questo poi ne riparliamo magari in un'altra puntata. Però è per dire che secondo me anche questo divieto non è per non far distrarre gli studenti, è per evitare che magari anche gli episodi di bullismo in classe vengano ripresi con i cellulari, poi questi video girino nelle chat, sui social media e creino problemi poi giganteschi. Il problema è proprio quello. Il problema è cosa ci fanno i ragazzi col cellulare. E quindi dovrebbero essere educati all'utilizzo consapevole del cellulare. Secondo me a partire dalla scuola, quindi non sequestrando i cellulari, ma insegnando come usare i cellulari in maniera utile e non fare danni con i cellulari. E poi chiaramente c'è l'altra faccia della medaglia, ovvero una volta usciti da scuola non è che "cellulare libero per tutti, tutta la giornata". Perché attualmente è così, no? La scuola dice "vi vieto il cellulare a scuola, a casa decideranno i genitori, fate quello che volete." Il problema è poi che in questa altra metà della giornata, anche i genitori, anche la famiglia deve continuare con questa educazione all'utilizzo della tecnologia. Matteo: [14:19] Sì sì sì sì, purtroppo l'educazione è un grande problema. Raffaele: [14:33] Dove eravamo rimasti? Ma inteso settimana scorsa? A Roma con i turisti che si rubavano le statue e le basi delle colonne: è successo di nuovo? Non dirmi che è successo di nuovo... Matteo: [14:49] È successo, più o meno. Niente monopattini, niente basi di colonne, ma a quanto pare dei turisti hanno fatto un guaio. Raffaele: [14:59] Un guaio bello grosso e bello caro, molto caro. Parliamo ancora di comportamenti sbagliati nei musei. Questa volta siamo a Verona, un museo che si chiama Palazzo Maffei, che ospita delle opere d'arte. In particolare un'opera d'arte di un artista contemporaneo italiano che si chiama Nicola Bolla, che ha riprodotto una sedia ispirata a uno dei quadri più famosi di Van Gogh. E l'ha riprodotta totalmente fatta di cristallo e Swarovski, quindi uno degli oggetti più fragili per definizione. Raffaele: [15:48] Ebbene, durante una visita a questo museo, una coppia quasi anziana, adesso non sappiamo molti dati, vediamo soltanto le immagini dei video di sorveglianza. Questa coppia di signori anziani, aspetta l'uscita della guardia poi si avvicina furtivamente alla sedia, che si chiama proprio "la sedia di Van Gogh". Fin lì tutto bene, puoi avvicinarti, puoi fare le tue foto. Solo che a un certo punto lui si china e si siede, si appoggia sull'opera d'arte. Adesso, secondo te: è fatta di cristallo, come può andare a finire? (Malissimo. In frantumi.) Esatto. La sedia si è immediatamente spaccata. E, tu dirai: i due mortificati avranno informato la guardia che stava poco distante in qualche altra sala. "Guardate, è successo questo, non volevo, l'ho urtata e si è rotta." Invece i furbastri sono scappati via, hanno fatto finta di nulla, hanno lasciato il museo e si sono dileguati. Le guardie del museo si sono accorte del danno troppo tardi, perché sono uscite dal museo per provare a rintracciare i colpevoli ma non li hanno potuti trovare. E quindi il museo ha fatto una denuncia contro ignoti, si dice in questo caso: è una cosa che è possibile fare quando non sai chi ha fatto il danno, il furto, fai una denuncia contro ignoti. E i carabinieri in questo caso si sono attivati, hanno preso la situazione molto seriamente, dal video sono riconoscibili in volto i due, si vede per bene l'abbigliamento, gli oggetti che portano con sé. E quindi per adesso non l'hanno trovati, ma chissà che non li troveranno a breve. Matteo: [17:55] Beh, ci sono spera... speriamo, ma non tanto per una questione di, come dire: "Voglio punirli". Però non vorrei che iniziasse questo nuovo sport di "fa il danno e poi scappa". Raffaele: [18:15] Sì, no, non va bene. Il danno, tra l'altro, la sedia vale tra i 15.000 e i 50.000 euro, quindi non parliamo di milioni di euro, però comunque è un danno non da poco. E hanno contattato l'artista: fortunatamente l'artista, dopo aver constatato i danni ha detto "ok, sì, la possiamo sistemare." Tra l'altro l'artista è stato intervistato dai giornali e l'ha presa sul filosofico, diciamo così. Ha detto "No, non ci sono rimasto male anzi ci ho visto qualcosa di ironico e positivo, mi è sembrata quasi una performance di arte moderna". Matteo: [19:00] Vabbè certo, è stata registrata, l'ha vista forse. Raffaele: [19:04] Eh, si sarà fatto una risata e ha detto "Mi ha dato persino lo spunto per la prossima opera da realizzare". Matteo: [19:11] Ah, incredibile. Raffaele: [19:13] "Sedia spezzata con turista immortalato accovacciato", chissà. Secondo me questo è il calore. Troppo caldo sta dando alla testa. Hai un antidoto per tutto questo caldo? Matteo: [19:26] Eh certo: andate a mare! Raffaele: [19:35] Eh vabbè ma il mare in Italia... Cioè l'Italia è tutta mare, è una penisola, c'è talmente tanto di quel mare che non sai dove andare. Dove andare a mare? Matteo: [19:48] Possiamo chiederlo ai mitici della bandiera blu. Raffaele: [19:55] La bandiera blu è uno degli strumenti che si utilizza in Italia per identificare le condizioni del mare delle spiagge italiane. Dare una bandiera blu ad una spiaggia vuol dire che lì l'acqua è pulita e bella, è l'idea di massima. Quest'anno in Italia, nel 2025, abbiamo 246 bandiere blu, quindi abbiamo almeno 246 posti da scegliere per avere l'acqua eccellente e addirittura recentemente c'è stato uno studio dei laboratori delle agenzie ambientali che hanno fatto una statistica e hanno visto che la regione con l'acqua più pulita, inteso meno inquinata in tutta Italia, è la Puglia. Il 99,7% delle acque è eccellente, ha una qualità eccellente, quindi l'acqua meno inquinata, praticamente 99,7% vuol dire che è perfetta. (Non male.) Più nello specifico, Matteo, tra l'altro le bandiere blu confermano questo trend e anche il maggior numero di bandiere blu in tutta Italia ce l'hanno Liguria, Puglia e Calabria, quindi si conferma la Puglia tra le migliori destinazioni. Tu sei stato in Puglia, sei stato al mare, ricordi qualche spiaggia, ti va di consigliarmi quella che secondo te è la spiaggia più bella d'Italia o la spiaggia più bella in cui sei stato in Italia? Matteo: [21:40] Allora, io sono stato in Puglia sì. Sono stato nel Gargano. Quindi la parte vicino al tallone dello stivale. E poi sono stato al confine con la Puglia, nel Molise, più verso nord. Siamo andati ogni tanto, siamo sconfinati in Puglia, spiagge un po' più sabbiose. Non sono andato ma dicono che un posto meraviglioso sono le isole Tremiti. Raffaele: [22:18] Eh sì. Matteo: [22:20] Che sono di fronte la Puglia e il Molise. Raffaele: [22:23] Esatto, sono un po' bistrattate, vuol dire maltrattate, spesso dimenticate quando si parla di isole italiane perché pensano tutti quanti alle isole della Sicilia. Mentre invece le Tremiti in Puglia sono una destinazione turistica bella, bella, bella. Matteo: [22:45] Sì. Raffaele: [22:46] Io sono stato in Puglia, non sono stato a mare in Puglia, perché sono stato in inverno, anche nei luoghi insomma che poi d'estate sono belli affollati. Però non ho avuto la possibilità di godere della spiaggia quando sono stato in Puglia. Quindi la mia selezione varia un po' tra Lazio e Campania soprattutto. Ed in particolare ti voglio raccomandare in Campania Marina d'Ascea, anche qui Bandiera Blu, una bella spiaggia ampia, mare molto pulito. Ma non solo, ce ne sono tante. C'è Palinuro. C'è un posto adesso non mi ricordo neanche più come... insomma, in quale zona specificamente si trova. Quando eravamo più ragazzini con la famiglia andavamo in un posto che si chiama "lo scoglio della tartaruga". E si trova a Vico Equense, in provincia di Napoli, non troppo lontano da Sorrento. Ed era un posto fantastico perché tu arrivavi, poi dovevi prendere la barchetta e la barchetta ti portava in questa spiaggia. Si chiama scoglio della tartaruga perché ci sono dei sassi poco distante dalla spiaggia che hanno proprio la forma di una tartaruga. E c'era l'abitudine, adesso non penso sia più consentito, di arrampicarsi su questa tartaruga e tuffarsi dalla testa o dal guscio della tartaruga. Non ci sei mai stato? Non ne hai mai sentito parlare? Matteo: [24:27] No, ricordo vagamente. A Vico Equense ci sono stato spesso quando ero piccolo e tutta quella parte lì è fantastica, ci sono delle spiagge e dei panorami e dei profumi bellissimi. Pino, mi ricordo sempre questo profumo di pino, l'albero e il mare che assieme creano un... Guarda, mi sento a mare adesso solo a pensarci. Raffaele: [25:01] Eh, ma io... infatti questo è un esercizio psicologico. Se penso alla spiaggia e al mare, automaticamente mi rinfresco. Nel Lazio ti consiglio una spiaggia che si chiama Serapo. Tecnicamente la zona, la cittadina a cui appartiene si chiama Gaeta, quindi siamo tra Napoli e Roma, non troppo lontano da Terracina che menziono sempre. Ed è insomma una bella bella spiaggia. Occhio al traffico, non facilissima da raggiungere, bisogna parcheggiare, poi fare delle scalinate... però insomma merita. Secondo alcuni la spiaggia più bella in Italia invece è la spiaggia dei conigli a Lampedusa. Matteo: [25:46] Non ci sono mai stato, è molto famosa tant'è vero che ne ho sentito già parlare. Raffaele: [25:52] Eh sì, effettivamente guardare le foto... sembra di guardare i Caraibi o addirittura le Maldive o la Polinesia. Matteo: [26:02] Ce ne sono tantissime che ricordo in Sardegna. Raffaele: [26:06] Esatto, volevo dire questo. Cioè che ognuno può avere la sua preferita, io non sono mai stato in Sardegna, però secondo tanti le spiagge più belle in Italia sono proprio in Sardegna. Secondo posto forse per la Sicilia e poi Puglia ed altre. Però grosso modo l'idea collettiva è questa: le spiagge più belle in Italia sono in Sardegna. Sei mai stato a mare in Sardegna? Matteo: [26:36] Sì, sono stato a mare in Sardegna per un paio d'anni da giovane, liceale, sono andato con gli amici, ed è stato, penso, il mare più bello che abbia mai visto in vita mia: bellissimo. Limpidissimo. Raffaele: [26:59] Facciamo così: me ne parli un poco nel nostro after show, ci spostiamo di là e approfondiamo questo argomento, e anche qua parliamo di qualche altra cosa. Matteo: [27:12] È vero perché ho fatto qualcosa. Raffaele: [27:15] Cosa hai fatto? Matteo: [27:16] Mistero? Raffaele: [27:17] Mistero: se volete sapere cosa ha combinato Matteo dovete seguirci nel nostro after show. Ricordate che è uno dei nostri bonus per i sostenitori, i membri della nostra comunità. Quindi non perdete tempo, cliccate sul link nelle show notes, diventate sostenitori di Easy Italian, riceverete l'after show, la trascrizione integrale interattiva della puntata, la traduzione multilingue, ed il Vocab Helper che mostra a schermo fino a 10 tra le parole più importanti o più difficili minuto per minuto. E che vuoi di più dalla vita? Matteo: [27:55] Una spiaggia e del mare. Raffaele: [27:59] Io stavo per dire un Lucano... Matteo: [28:01] Ciao. Ciao.

Più soldi alla NATO e i membri si spaccano. Eutanasia legale in Inghilterra e Galles Questo podcast e gli altri nostri contenuti sono gratuiti anche grazie a chi ci sostiene con Will Makers. Sostienici e accedi a contenuti esclusivi su willmedia.it/abbonati Learn more about your ad choices. Visit megaphone.fm/adchoices

Shawn and Alex welcome Dr. Michael Niccole, plastic surgeon PI expert, to discuss everything from scar revision to long-term disfigurement claims, teaching how strategic cosmetic care can help your change a PI patient's life.

Pişti ku hindek hestî û keleyê serê mirovan dnava şikefta Şaneder li parêzgeha Hewlêr hate ditin. Bi hezaran xelk û geştîyar, şûnwarnas û dîroknas seredana wê şikeftê dikin. Rojane bi sedan şandên cûda cûda yên dîrokî, kesatîyên akademî serdana şikeftê dikin.

Piööc Thuɔ̈ŋjäŋ tɛn miith aci kë puɔ̈lic ee ke wïc mɛ̈tmɛ̈t dhël yam bi keek piɔ̈ɔ̈c ku bïk nhiaar yic.

In this new episode, Tim Pilleri and Lance Reenstierna host a live fundraiser for the non-profit, Private Investigations For the Missing. This is part 2 of 2. Guests for the evening include Julie Murray (sister of Maura Murray), Bobby Taghavi (Golden State Killer task force), Dr. Trace Sargent (profiler & search dog trainer), private investigator Jason Watts (Brandon Lawson case), and PI's Greg Overacker and Lou Barry to discuss some new information in Brianna Maitland's disappearance. Follow Private Investigations For the Missing and please donate if you can: ⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠. ⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠. ⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠. ⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠. ⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠. Follow Dr. Trace Sargent: https://www.forensicinvestigations.org/. Get Greg's book on the disappearance of Brianna Maitland: https://books.bloatedtoe.com/book-contributor/gregory-j-overacker/. Check out Happy Mammoth and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://happymammoth.com⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mood and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://mood.com⁠⁠⁠⁠⁠⁠⁠⁠⁠. Main Theme by Kevin Macleod. Check out his work at ⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at ⁠⁠⁠⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠. TT:⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠. Spotify:⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠. Youtube:⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠. TT:⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠ Spotify:⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠. Youtube:⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠. Check out our entire network at⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Female Athlete Nutrition Podcast, host Lindsey Elizabeth Cortes, sports dietician and athlete, discusses menstrual health with guest Margo Harrison, a board-certified OB-GYN and founder of WaveBye Inc. They delve into the high expectations on women's bodies, nutritional confusion, and the impact of menstrual cycles on daily life and athletic performance.Margo shares the mission behind WaveBue Inc., a menstrual health company focused on enabling women to manage their menstrual symptoms effectively. The episode covers traditional and innovative treatments for menstrual pain, the importance of tracking and understanding one's cycle, and the evidence-based natural ingredients in WaveBye products, such as vitamin E, magnesium, inositol, and Chasteberry. Lindsey also provides insights from her own experience with the product and offers a special discount for listeners.Episode Highlights:01:26 Meet Our Guest: Margo Harrison02:10 Understanding Menstrual Health and Nutrition03:30 Personal Experiences and Insights06:30 Challenges and Solutions for Menstrual Pain23:54 Exploring WaveBye Products27:56 Addressing RED-S in Female Athletes30:29 Conclusion and Final Thoughts30:54 Understanding the Importance of Tracking Your Cycle32:00 Managing Irregular Cycles and Ovulation34:35 Ingredients and Their Benefits38:56 Personal Experiences and Testimonials47:30 Contraindications and Who Should Avoid These Products50:39 Final Thoughts and RecommendationsMargo is a board-certified OB/GYN who was an NIH-funded academic PI at the University of Colorado. Since leaving academic medicine, she has been a provider at Planned Parenthood of the Rocky Mountains and founded a femtech consulting firm that served over twenty venture-backed companies in the women's health space in areas of clinical research, strategy, business development, and medical affairs. She is now the founder and CEO of Wave Bye Inc., a menstrual health company that exists to enable women to fulfill their human potential. DISCOUNT CODE for 15% off: LINDSEYCORTESDirect referral link for discount: https://www.wavebye.co/?ref=LINDSEYCORTESVisit WaveBye's Website: http://wavebye.coFollow WaveBye:@wavebyeinc on Instagram@wavebyeinc on TikTok@WaveByeInc on YouTubeFor more information about the show, head to work with Lindsey on improving your nutrition, head to:http://www.lindseycortes.com/Join REDS Recovery Membership: http://www.lindseycortes.com/redsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

¿Creías que habías visto todo en el mundo de los videojuegos? Piénsalo otra vez. Desde un simulador del 23-F con Tejero como Pac-Man hasta citas románticas con palomas, pasando por recrear el asesinato de JFK o desahogarte con tu jefe usando un trasero de plástico... En este episodio exploramos los rincones más oscuros y perturbadores de la industria del videojuego. Títulos que desafían la lógica, que generaron polémicas masivas o que simplemente nacieron de mentes que claramente necesitaban unas vacaciones. ¿Qué lleva a alguien a crear un juego sobre el golpe de Tejero? ¿Por qué los japoneses pensaron que necesitábamos ligar con palomas? Te contamos las historias detrás de estos experimentos digitales que demuestran que vivimos en la época más extraña de la historia. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

V Ljubljani je študiral elektrotehniko in prejemal številna priznanja, v Münchnu magistriral, na prestižni tehnični univerzi v Zürichu pa doktoriral. Pri tridesetih ima v Švici svoje podjetje, ki se ukvarja z blockchainoim; to ga je zanimalo že v obdobju študija. Zasebnega in službenega časa nima jasno razmejenega. To, da je gospodar svojega časa – priznava, da je celo bolj točen od pregovorno točnih Švicarjev – pa mu pomaga tudi pri vzdrževanju razmerja na daljavo. Partnerica, Makedonka, namreč še vedno živi in deluje v Nemčiji, v katero sta se skupaj odpravila na podiplomski študij. Kje si bosta ustvarila družino, še ne ve. Švica ni samoumeven odgovor, pove.Poznate potencialnega sogovornika ali sogovornico za epizodo Globalne vasi? Pišite na nejc.jemec@rtvslo.si

In this new episode, Tim Pilleri and Lance Reenstierna host a live fundraiser for the non-profit, Private Investigations For the Missing. This is part 1 of 2. Guests for the evening include Julie Murray (sister of Maura Murray), Bobby Taghavi (Golden State Killer task force), Dr. Trace Sargent (profiler & search dog trainer), private investigator Jason Watts (Brandon Lawson case), and PI's Greg Overacker and Lou Barry to discuss some new information in Brianna Maitland's disappearance. Follow Private Investigations For the Missing and please donate if you can: ⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠. ⁠⁠⁠http://piftm.org/donate⁠⁠⁠. ⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠. ⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠. ⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠. Follow Julie Murray: https://www.mauramurraymissing.org/. Media Pressure podcast: https://www.mauramurraymissing.org/podcast.html. Julie on social media: https://www.tiktok.com/@mauramurraymissing. https://www.instagram.com/mysistermauramurray/. Bobby Taghavi's site: https://sweetjames.com/attorney/bobby-taghavi/. Bobby Taghavi on Instagram: https://www.instagram.com/bobbytaghavi. Check out Happy Mammoth and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠https://happymammoth.com⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mood and use my code MISSING for a great deal: ⁠⁠⁠⁠⁠⁠⁠⁠https://mood.com⁠⁠⁠⁠⁠⁠⁠⁠. Main Theme by Kevin Macleod. Check out his work at ⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠. Additional music by David Williams. See his work at ⁠⁠⁠⁠http://williamsflutes.com⁠⁠⁠⁠. Follow Missing: IG:⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠. TT:⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠. FB:⁠⁠ https://www.facebook.com/MissingCSM⁠⁠. X:⁠⁠ https://twitter.com/MissingCSM⁠⁠. Spotify:⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠. Youtube:⁠⁠ https://www.youtube.com/missingcsm⁠⁠. Apple:⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠. Follow Crawlspace: IG:⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠. TT:⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠. FB:⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠. X:⁠⁠ https://twitter.com/crawlspacepod.⁠⁠ Spotify:⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠. Youtube:⁠⁠ https://www.youtube.com/crawlspace⁠⁠. Apple:⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠. Check out our entire network at⁠⁠ http://crawlspace-media.com/⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

What happens when we take numbers seriously—not just at face value, but in terms of their actual impact on our lives? This week, Reid and Aria are joined by UK-based mathematician and media personality Hannah Fry to explore this deceptively simple question. From cancer diagnoses to dating apps, Hannah makes the case that understanding the math behind our decisions—and the "game" we're really playing—is essential to building a better future.  They discuss why regret minimization is often a better guide than raw percentages in assessing risks; Hannah's advice on finding love in a sea of swipe-rights; and how a well-framed question can be more powerful than the right answer. Plus, Inflection's Pi chimes in with a few Jane-Austen-themed math jokes. For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/  Topics: 3:01 - Hellos and intros 3:15 - Considering hairdressing, instant feedback, and becoming a broadcaster 5:11 - Making math emotionally resonant 7:37 - Math as power and who gets to shape the future 9:10 - Understanding AI through probabilities and spectrums 12:01 - The emotional limits of statistics in medical decision-making 16:22 - Choosing the right “game” to optimize for 19:57 - How to build systems that self-correct 23:19 - Rethinking education and assessments in the AI era 26:42 - Updating dating advice for the AI age 30:03 - Real-life “Black Mirror” 36:11 - Storytelling vs. statistics 41:47 - Probability thinking, AI confidence, and useful heuristics 45:31 - Pi delivers math-themed Jane Austen jokes 47:15 - Rapid-fire questions Select mentions:  Google DeepMind: The Podcast The Mathematics of Love TED Talk When We Cease to Understand the World by Benjamín Labatut “Women also Snowboard: Overcoming Bias in Captioning Models” by Kaylee Burns, Lisa Anne Hendricks, Kate Saenko, Trevor Darrell, and Anna Rohrbach Possible is an award-winning podcast that sketches out the brightest version of the future—and what it will take to get there. Most of all, it asks: what if, in the future, everything breaks humanity's way? Tune in for grounded and speculative takes on how technology—and, in particular, AI—is inspiring change and transforming the future. Hosted by Reid Hoffman and Aria Finger, each episode features an interview with an ambitious builder or deep thinker on a topic, from art to geopolitics and from healthcare to education. These conversations also showcase another kind of guest: AI. Each episode seeks to enhance and advance our discussion about what humanity could possibly get right if we leverage technology—and our collective effort—effectively.

ANTIFA THUG treats Police Officer's head like a Piñata! FAFO!

EPISODE 139 | A Numbers Game: Mathspiracies Guest: Gary Arndt, writer and host of the Everything Everywhere Daily podcast We aren't really very good with numbers, so naturally we've come up with a lot of wacky ideas about them. Gary Arndt talks about numbers of all sorts, like why Pi is stupid, why prime numbers are cool, why the Fibonacci sequence isn't all that, when math leads to murder and much more. Like what we do? Then buy us a beer or three via our page on Buy Me a Coffee.  Review us here or on IMDb. And seriously, subscribe, will ya?  SECTIONS 02:25 - Numeracy rates, gambling is (usually) a sucker's bet, numerology, the Bible Code, p-hacking, Equidistant Letter Sequencing (ELS) 13:09 - The Hidden Hand of Mathematics, the Ultraviolet Catastrophe and the birth of quantum physics, the Fibonacci sequence and the Golden Ratio 20:05 - Pi, tau, the Cult of Pythagoras, irrational numbers, transcendental numbers, squaring the circle, Alex Jones and math, the real number of the Beast 28:51 - Why people believe conspiracy theories 30:13 - Angel numbers, the "meanings" of numbers 33:43 - Numbers stations 37:25 - Prime numbers, Prime Target TV series, trapdoor functions in cryptography, Al-Khwarizmi, double entry bookkeeping, the idea of zero, zero and null are different 43:20 - Base-10, base-12, base-60, and our timekeeping and calendar systems Music by Fanette Ronjat More Info Everything Everywhere Daily podcast The Bible Code book review in Notices of the AMS The Significance of The Number Forty-Two (42) by By Rabbi Dr. Hillel ben David (Greg Killian) Magic Apologetics: Equidistant Letter Sequencing in the Christian Research Journal Assassinations Foretold in Moby Dick! THE UNREASONABLE EFFECTIVENSS OF MATHEMATICS IN THE NATURAL SCIENCES by Eugene Wigner The Ultraviolet Catastrophe and the Creation of Quantum Mechanics episode of Everything Everywhere Daily What is the Fibonacci sequence? on LiveScience Fibonacci Sequence on Math Is Fun Composing Balanced Images: The Golden Ratio on ProGrade Digital Everything You Need to Know About Pi episode of Everything Everywhere Daily Why Tau Should Replace Pi episode of Everything Everywhere Daily The Cult of Pythagoras episode of Everything Everywhere Daily Irrational Numbers episode of Everything Everywhere Daily Squaring the Circle episode of Everything Everywhere Daily e: Euler's Number episode of Everything Everywhere Daily Pi Is Encoded in the Patterns of Life Alex Jones and 666 video A Guide to Angel Numbers and What They Mean Numerology Numbers 1-9: Exploring the single digit numbers in Numerology on Numerology.com Numbers Stations episode of Everything Everywhere Daily Number Stations on Priyom.org Number Station Recordings - Creepy radio broadcasts from unknown origins (video with over 4 hours of recordings) All About Cryptography episode of Everything Everywhere Daily Prime Numbers episode of Everything Everywhere Daily Prime Target TV series on IMDb Zero, My Hero episode of Everything Everywhere Daily Zero and NULL values  What is the Base-10 Number System? Base 12: An Introduction Babylonian Mathematics and the Base 60 System Follow us on social: Facebook Twitter Bluesky Other Podcasts by Derek DeWitt DIGITAL SIGNAGE DONE RIGHT - Winner of a Gold Quill Award, Gold MarCom Award, AVA Digital Award Gold, Silver Davey Award, and Communicator Award of Excellence, and on numerous top 10 podcast lists.  PRAGUE TIMES - A city is more than just a location - it's a kaleidoscope of history, places, people and trends. This podcast looks at Prague, in the center of Europe, from a number of perspectives, including what it is now, what is has been and where it's going. It's Prague THEN, Prague NOW, Prague LATER   

In this illuminating episode of Better Buildings for Humans, host Joe Menchefski welcomes physicist and daylighting pioneer Marilyne Andersen for a conversation that sheds new light—literally—on how architecture affects our health, productivity, and sense of well-being. From the science of chronobiology to eye morphology and colored glazing, Marilyne explains how light exposure shapes everything from our mood to our sleep cycles. She shares insights from her groundbreaking research at EPFL and her work with the Daylight Academy, revealing why daylight may be more than a design feature—it might be a human right. Plus, discover how her new role at GESDA is helping bridge the gap between scientific discovery and societal impact. A must-listen for anyone designing spaces for real human needs.More About Marilyne Andersen:Marilyne Andersen is a Full Professor at EPFL and head of the LIPID lab since 2010, after 6 years at MIT as tenure-track professor. Since April 2025, she is also the Director General of the GESDA foundation (Geneva Science and Diplomacy Anticipator), whose mission is to anticipate emerging scientific discoveries and translate them into concrete actions for the benefit of society by engaging proactively with policymakers and diplomats. Physicist by training, she specializes in the psycho-physiological effects of (day)light with broader research interests on sustainability in the built environment. She has been Dean of ENAC at EPFL (2013-2018), Academic Director of the Smart Living Lab until 2024 and member of the Board of the Holcim Foundation for Sustainable Construction (2015-2024). She was also Visiting Professor at the Lawrence Berkeley Lab in California and at SUTD in Singapore. Author of over 250 refereed papers with several distinctions, she was the global Daylight Research Award's inaugural laureate in 2016 and led the winning Swiss team for the Solar Decathlon 2017 competition. At EPFL, she is currently Head of the SKIL for project-based learning and PI of the Swiss-wide SWICE consortium on the energy transition. She is also co-founder of the consulting startup OCULIGHT dynamics.In parallel, she has been actively engaged in bridging the gap between art and science, notably since 2021 as co-curator of the exhibition entitled Lighten Up! On Biology and Time and as author of the Circa Diem immersive installation and policy-oriented fiction Droit au Jour ; these works have been on display in diverse venues such as the Seoul Biennale, the EPFL Pavilions, the Gewerbemuseum Winterthur, the Museum of Contemporary Design and Applied Arts (mudac) in Lausanne, and will be showcased at the MIT Museum in 2025-2026.CONTACT:https://www.linkedin.com/in/marilyne-andersen-b617aa1/https://people.epfl.ch/marilyne.andersen Where To Find Us:https://bbfhpod.advancedglazings.com/www.advancedglazings.comhttps://www.linkedin.com/company/better-buildings-for-humans-podcastwww.linkedin.com/in/advanced-glazings-ltd-848b4625https://twitter.com/bbfhpodhttps://twitter.com/Solera_Daylighthttps://www.instagram.com/bbfhpod/https://www.instagram.com/advancedglazingsltdhttps://www.facebook.com/AdvancedGlazingsltd

Agli inizi, prima del boom, le critiche più dure non arrivavano dal pubblico... ma da altri divulgatori. Più esperti, più rigidi, più inquadrati. Non capivano come lo stile e l'approccio divulgativo di Barbascura potessero essere molto più apprezzati sui social rispetto al loro. Ma, alla lunga, ha vinto l'immediatezza, la spontaneità e l'originalità di "Scienza brutta". Puntata completa nel

The line between a maker and a maker pro is quite fuzzy. In my opinion, the maker wants to build one of something, and likely won't want to build more than one. The maker pro starts out building one, but knows somewhere down the line that the project could turn into a far larger volume. If you fall into that latter group, does that change some of your design decisions, even where you begin? Do you start with a Pi, or do you use something that's more “professional?” This is the conversation I had with Okan Saracoglu, the Vice President of Growth at Sixfab. Hear what he had to say on the subject forward, on this week's Embedded Executives podcast.

We surveyed over 250 attorneys across the country to find out what's really working in PI marketing and where firms are falling short. In this webinar replay from Rankings.io you'll get insights about how budget trends and channel performance to the growing divide between small and large firms. This webinar was packed with real data and real strategies you can act on now. UP NEXT:  AI Optimization for Lawyers: Search Has Changed. Most PI Firms Haven't. If your firm doesn't have a plan to adapt to AI-driven search, it won't be long before the flow of signed cases dries up. Date: June 24, 2025 Time: 12 PM - 1 PM CST WHERE: Rankings.io/Webinars  Plus, we'll open the floor for live Q&A so you can get actionable insights tailored to your firm. Register now at rankings.io/webinars to secure your spot and get an inside look at the future of legal marketing. Get Social! Personal Injury Mastermind (PIM) is on Instagram | YouTube | TikTok

Did you like the episode? Send me a text and let me know!!Mastering the Stigma of Asking for Help in EntrepreneurshipIn this episode of Business Conversations with Pi, host Skoob and AI co-host Pi, created by the innovative minds at Anthropic, delve into the importance of overcoming the stigma associated with asking for help in the entrepreneurial world. They discuss strategies to build a strong support network, the benefits of seeking assistance, and recommend valuable resources and books to further your understanding. Tune in to learn how vulnerability and mutual support can be the keys to your business success.Help Me! by Marianne PowerDaring Greatly by Brené BrownThe 5 Love Languages by Gary ChapmanNever Eat Alone by Keith Ferrazz00:00 Introduction to Business Conversations with Pi00:38 Meet Your Hosts: KU and Pi01:55 The Power of Asking for Help02:45 Strategies for Overcoming the Stigma03:43 Benefits of Asking for Help04:29 Who to Turn to for Help05:17 Recommended Reading for Entrepreneurs06:22 Final Thoughts and Encouragement06:54 Closing Remarks and Next Steps Thank you for being a Skoobeliever!! If you have questions about the show or you want to be a guest please contact me at one of these social mediasTwitter......... ..@djskoob2021 Facebook.........Facebook.com/skoobamiInstagram..... instagram.com/uepodcast2021tiktok....... @djskoob2021Email............... Uepodcast2021@gmail.com Skoob at Gettin' Basted Facebook PageAcross The Start Line Facebook Community If you would like to be coached on your entrepreneurial adventure please email me at for a 2 hour free discovery call! This is a $700 free gift to my Skoobelievers!! Contact me Now!! On Twitter @doittodaycoachdoingittodaycoaching@gmailcom

This week, I got to talk with Kimberly G. Giarratano about her newest installation in the noir Billie Levine series, Make a Killing! We dive into what was different about writing this one, how she landed on a luxury luggage company for the story, and how capitalism has seeped into college.Make a Killing SynopsisPrivate Investigator Billie Levine should be ecstatic. She's finally getting the cheating spouse cases she's always wanted. Nothing to do but sit back, snap incriminating photos, and get paid. Except Jeremy Yang is competing for work with his own P.I. firm. Advertising himself as “the man to get the job done” (insert eyeroll), he keeps swooping in and stealing prospective clients. Not to be outmaneuvered, Billie has offered her services to scorned women everywhere.Their rivalry escalates when Billie and Jeremy are hired by an ultra wealthy couple on opposite sides of a corporate takeover. When the bodies start dropping, Billie and Jeremy will have to join forces if they are to come out unscathed; they can kill each other later. Check Out My Stories Are My Religion SubstackCheck Out Author Social Media PackagesCheck out the Bookwild Community on PatreonCheck out the Imposter Hour Podcast with Liz and GregFollow @imbookwild on InstagramOther Co-hosts On Instagram:Gare Billings @gareindeedreadsSteph Lauer @books.in.badgerlandHalley Sutton @halleysutton25Brian Watson @readingwithbrian

„Český fotbal dlouhodobě stagnuje,“ říká Jaroslav Hřebík, někdejší trenér Sparty i Slavie, odborník na moderní fotbalové trendy. Výkony a výsledky reprezentace v Chorvatsku i „lvíčat“ na ME „21“ na Slovensku mu dávají za pravdu.Řada fanoušků, ale i lidí uvnitř českého fotbalu mu dodnes nemůže přijít na jméno. Jaroslav Hřebík totiž vždycky veřejně říkal věci, které se mnohým nelíbily, obvykle proto, že je nechápali. A byly jim nepříjemné, takříkajíc proti srsti. Měli za to, že svým „vědátorským“ přístupem doslova ničí fotbal. Stejně jako když prosazoval taktiku vysunutého presinku - dnes základního prvku moderní fotbalové abecedy, na kterou přísahají všichni Kloppové, Guardiolové a další. Vysvětlit ale před 20 lety hvězdám Sparty, včetně Karla Poborského, že se po ztrátě míče mají hned pokusit ho zase získat, byl tehdy prostě problém. I proto, že si vznětlivý Hřebík nebral nikdy servítky. Nicméně vývoj mu dal prakticky ve všem, co kdy hlásal, jasně za pravdu. Ať se tomu pohodlné české fotbalové prostředí vzpíralo sebevíc.V aktuální epizodě Nosičů vody mluví Jaroslav Hřebík s typickou přímočarostí o slabých výkonech české reprezentace i jednadvacítky v Chorvatsku a na Slovensku, o tom, v čem podle něj čeští hráči zaostávají za zahraničními kolegy i jak to napravit. Vrací se k dávným roztržkám s Patrikem Schickem nebo k tomu, čím ho už při prvních setkáních zaujali Coufal a Souček.---Nosiči vodyFotbalový podcast Seznam Zpráv. Jaromír Bosák, Luděk Mádl a Karel Tvaroh každý týden o českém a světovém fotbalu. Příběhy, aféry, důležité postavy na hřišti i v zákulisí.Odebírejte na Podcasty.cz, Apple Podcasts nebo Spotify.Sledujte nás na Twitteru! Najdete nás tam jako @Nosicivody.Máte návrh, jak podcast vylepšit? Nebo nás chcete pochválit? Pište na audio@sz.cz.

Można Pięknie Żyć *---Witaj! "Można Pięknie Żyć*" to seria podcastów, w której odkrywamy, jak zmiany w stylu życia mogą poprawić nasze zdrowie metaboliczne. Skupiamy się na Terapeutycznym Ograniczaniu Węglowodanów i jego pozytywnym wpływie na metabolizm oraz ogólne samopoczucie. Pamiętaj, że zdrowie zaczyna się od wiedzy, a my jesteśmy tu, aby dostarczać Ci inspirację i praktyczne wskazówki na drodze do pięknego życia.

Episode 243 :       Welcome to the next episode of Pi Perspectives. Matt is back with California PI, Joe Jones. Joe is a second-generation PI who built a great business with his brothers after learning from their dad. What do you do when you can't keep up with the growth? Stick around and find out. Please welcome Joe Jones and your host, NY Private Investigator, Matt Spaier  Links:      Matt's email: MatthewS@Satellitepi.com   Linkedin: Matthew Spaier       www.investigators-toolbox.com   Joe on Linkedin: Joseph Jones Email: Joejones@Magnals.com 
 PI-Perspectives Youtube link:  https://www.youtube.com/channel/UCYB3MaUg8k5w3k7UuvT6s0g Sponsors:     https://piinstitute.com/ https://www.skopenow.com https://researchfpr.com/ https://www.trackops.com FBI Tip Line https://tips.fbi.gov/home https://www.fbi.gov/contact-us/field-offices/newyork/about - (212) 384-1000

Kako prihranke preusmeriti iz pasivnega stanja na računu v reden tok prihodkov? Dividendne strategije smo že obdelali epizodi Dividendni kralji: Kako z investiranjem do pasivnih zaslužkov?, se bomo tokrat osredotočili na obveznice, ki prinašajo obresti. Hkrati pa v razburkanih in negotovih časih lahko prinesejo tudi miren spanec. Pred mikrofonom: Blaž Hribar, član uprave, Pokojninska družba A V tokratni epizodi boste slišali: 00:00 Uvod v pasivne dohodke 02:58 Vrednotenje delnic in obveznic 06:11 Trendi na obvezniškem trgu 09:11 Primerjava ameriških in romunskih obveznic 12:11 Razumevanje obveznic 15:04 Tveganja in donosnosti obveznic 17:58 Strategije za vlagatelje 21:08 Obveznice in inflacija 31:35 Tveganja in obveznice 34:26 Zakladne menice in njihova likvidnost 38:07 Struktura naložb in obveznic 41:00 Valutno tveganje in obveznice 44:11 Pasivni dohodek in obveznice 46:57 Nepremičnine kot naložba 50:12 Demografski izzivi in naložbe 52:13 Folklora posojanja in obveznice Investicijski bootcamp za mlade (od 17 do 21 leta) Darilo z dodano vrednostjo ob koncu šolanja in ob vstopu v polnoletnost Spoznali bodo tudi 18.-letnega Marka, ki bo razkril, kako je sestavljen njegov portfelj. Število mest je omejeno. Datum: 21. avgusta v živo Boot Camp v živo: Investiranje – kako sploh začeti Že dolgo razmišljaš o vlaganju in ne veš, kje in kako začeti? Nimaš energije, da bi raziskoval vse podrobnosti. Skrbijo te davki? Presekaj in se nam pridruži v živo, kjer bomo skupaj naredili prvi korak v svet investiranja! Delavnica je neodvisno pripravljena, kar je redkost v današnjem času :) Lokacija: Ekonomska fakulteta Datum: 18. september Čas: 17:00–20:30 Podprite Money-How preko članstva na Youtube članstvo Pridruži se skupnosti Discord Money-How Obišči spletno stran Money-How Imaš vprašanje? Piši mi na marja@money-how.si

What is it that drives trolling online? Is Influencer, Indy Clinton right in taking legal action with her 64-page PI report? Plus, we introduce a new segment, 'Judge Jackie' where Jack decides whether something is cool or uncool!See omnystudio.com/listener for privacy information.

¿Sabes esa sensación cuando descubres una newsletter/podcast y no sabes por dónde empezar?Es muy posible que le esté ocurriendo a tu audiencia.Llegan a tu perfil, ven un montón de artículos y se van tan rápido como llegan. Es como cuando vas a un restaurante sin carta y el camarero te dice "tenemos de todo".Pues ese problema tiene una solución: la publicación destacada de Substack.Hoy te cuento cómo crear la tuya y al final del contenido te paso un ejemplo y los autores de esta idea.Qué es una publicación destacada en SubstackUna publicación destacada es exactamente lo que suena: un artículo que puedes fijar en la parte superior de tu newsletter.Es lo primero que verán tus lectores cuando lleguen a tu perfil de Substack.Piénsalo como el escaparate de una tienda. O como la portada de una revista. O como ese amigo que cuando llega alguien nuevo al grupo dice "déjame que te presente a todo el mundo".Antes de que te pongas a leer por ahí sin rumbo, empieza por aquí"Por qué es importante tener unaLa mayoría de creadores en Substack no tienen publicación destacada. Y los que la tienen, normalmente ponen cualquier cosa.Error.Imagínate que llegas a un podcast que lleva 200 episodios. ¿Por dónde empiezas? Exacto, necesitas una guía.Cómo debe ser tu publicación destacadaAquí es donde se comete el error más importante. Pinean su primer artículo y se olvidan del tema.Una buena publicación destacada tiene esta estructura:1. Hook que conecta con el problemaEmpiezas hablando del dolor real de tu audiencia. No de ti, no de tu newsletter. Del problema que resuelves.En FailAgain empiezo con: "Es lunes y todavía no sabes qué vas a publicar esta semana."Un dedo en el ojo.2. Momento de transformaciónPintas cómo sería su vida si ese problema estuviera resuelto."Imagínate que el domingo por la noche ya supieras exactamente qué vas a crear la semana que viene."3. Recursos gratuitos para empezarDas valor inmediato. Tres recursos máximo. Que puedan aplicar hoy mismo.4. Archivo organizado por temasAquí es donde separas el trigo de la paja. Organizas todo tu contenido por categorías claras.No pongas 47 enlaces sin orden. Elige los mejores de cada tema.5. Quién eres (al final, no al principio)Cuando ya has dado valor, te presentas. Una presentación honesta, sin mucho postureo.6. Llamada a la acciónAl final del todo. Sin agobiar, pero sin esconderte, puedes venderle lo que te interese. Recuerda que puede ser uno de tus primeros impactos, no seamos muy pesados.Errores que debes evitarError #1: Fijar tu primer artículo y olvidarte Tu primer artículo puede estar bien, suele ser un contenido donde explicas tus intenciones y te presentas, pero lo normal es que se quede anticuado con el tiempo.Error #2: Hablar de ti en el primer párrafo Prioridades. A tu audiencia le importa un carajo quién eres si no sabe qué problema le vas a resolver.Error #3: Meter todos los enlaces que tienes Menos es más. Elige los mejores de cada categoría.Error #4: No actualizarla nunca Tu publicación destacada debe evolucionar con tu contenido y actualizarse de forma recurrente.Mi proceso recomendadoCada 3-4 meses revisar mi publicación destacada y plantear estas preguntas:* ¿Sigue conectando con el problema principal de mi audiencia?* ¿Los recursos gratuitos que ofrezco son los mejores que tengo?* ¿Hay artículos nuevos que deberían estar en el archivo organizado?* ¿La estructura sigue funcionando o necesita cambios?No es algo que haces una vez. Es algo vivo.Cómo empezar hoy mismoSi no tienes publicación destacada:* Identifica el problema principal que resuelves para tu audiencia* Elige tus 3 mejores artículos (o recursos gratuitos si los tienes)* Escribe un hook que conecte con ese problema* Organiza el resto por temas claros* Fíjala en Substack (en configuración de la publicación)Si ya tienes una pero no funciona:* Revísala con la estructura que te he dado* Cambia el primer párrafo para que hable del problema, no de ti* Simplifica los enlaces (máximo 2-3 por categoría)Para terminarTu publicación destacada es la primera impresión que das. Y ya sabes lo que dicen de las primeras impresiones.La diferencia entre una newsletter que crece y una que no, muchas veces está en estas cosas que parecen pequeñas, pero no lo son.Dale una oportunidad extra a tu mejor contenido. Organízalo bien y verás cómo cambian las cosas.PD: Si quieres ver un ejemplo de cómo queda una publicación destacada bien hecha, échale un vistazo a la mía en FailAgain. No es perfecta, pero estoy en ello.PD2: Como te podrás imaginar, este invento no es mío. Se lo vi en un vídeo de YouTube a uno de los grandes creadores en Substack Nicolas Cole. Aquí te dejo el vídeo. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.guitermo.com/subscribe

Send us a message, so we know what you're thinking!A “Deep Cut” is something that is recognisable or familiar to passionate fans but not usually to others.  As a special treat this week, we've delved into our collections to give you some deep cuts from our favourites – things like Queen, Bowie, Joe Cocker, Nick Cave and TISM. We think you'll love them,   In Rock News, Jeff delves into songs that turn 60 on 2025, looks at Sunday Lunch with Toyah and Robert Fripp, and looks at Yachtley Crew, a strange phenomenon from California.  Our Album You Must Hear Before You Die this week is Raw Power (1973) by Iggy and the Stooges. The lo-fi production on this highly influential album is the source of much tension between Bowie and Iggy, much of it not fair. We liked it!  Enjoy.  Playlist  Songs that turn 60 this year  Sunday Lunch with Robert and Toyah  Yachtley Crew Peter Cook as The BishopREM on Letterman References:  Raw Power, Iggy Pop, The Stooges, John Cale, Columbia Records, Sex Pistols, Johnny Marr & The Smiths, Kurt Cobain, Nirvana, MainMan, Tony DeFries, Sonny Boy Williamson, Ron Asheton, Scott Asheton, “Gimme Danger”, “Search and Destroy”, Iggy on Countdown, radio-friendly, Bowie, “The Man Who Sold the World”, Unplugged, Roxy Music, “For Your Pleasure”, Roxy live in Sydney – 2001 & 2011, The Police, “Bring on the Night”, Regatta de Blanc, white reggae, T.S. Eliot, “The Love Song of J. Alfred Prufrock”, Joe Cocker, “Many Rivers to Cross”, Sheffield Steel, Queen, “Fairy Fellers Master Stroke”, Richard Dadd, State Criminal Lunatic Asylum of Bethlem Royal Hospital – Bedlam, Nick Cave, “Papa Won't Leave You, Henry”, Henry's Dream, John Cale, “Close Watch (I Keep a)”, Helen of Troy, Music for a New Society, Fragments of a Rainy Season, REM, "So. Central Rain (Sorry)", Reckoning, Lou Reed, “Street Hassle”, Warren Zevon, “Hit Somebody!  (The Hockey Song)”, My Ride's Here, Carl Hiassen, “Bad Monkey”, Vince Vaughan, David Letterman, Enjoy Every Sandwich, Jimmy Webb, “Galveston”, Kate Bush, Aerial, "Pi”, Pete Townshend, “The Sea Refuses No River”, All the Best Cowboys Have Chinese Eyes, TISM, Great Trucking Songs of the Renaissance, "The Ballad of John Bonham's Coke Roadie"  

In the Fall of 2021, Donald Trump was selling a hardcover book about his presidency called Our Journey Together. It would be self-published because it had to be. No publisher would touch it, no author would write it, and no critic would be caught dead praising it.January 6th was meant to be the end of the Trump story. He was to slink back to Mar-a-Lago, disgraced and a failure. They all said his book was a joke, a Putin-like rewrite of what really happened in his first term. Obviously, it had to be a lie - covering up the crimes, treason, and corruption.But something told me I should get that book anyway and hold onto it. It might matter someday. Maybe, I thought, the Trump story wasn't over quite yet.So I paid the hefty price for the signed copy and waited. When the package arrived, it came in a plain cardboard box. I breathed a sigh of relief because I thought if the UPS guy knew I was buying it, he might accidentally lose some of my packages next time, or who knows what else.I knew I wasn't a Trump supporter because I was still holding on to what I thought were my principles as a lifelong Liberal. I didn't vote for Trump in 2020, and as long as that was still true about me, I was protected from their wrath. I would find out years later just how bad it was to admit you supported Trump, let alone voted for him.Much of what we have experienced over the past ten years will be memory-holed. No one will remember how treacherous it was back then to buy Our Journey Together. Now, I keep it to remind me of what it felt like to be that afraid and how foolish I was to give them that much power over me.That's what Trump has done for the past ten years. He's refused to give the mighty empire power over his story. He's decided to tell it himself, even if he has to self-publish a book. He'll dress up in a tux with Melania and attend Les Miz at the Kennedy Center, even if some of them boo him. He'll celebrate his birthday on the same day as the 250th anniversary of the creation of the United States Army, even if they mobilize their infantile “No Kings” protest.Trump insists his version is the truth, and two narratives go to war every day. But the thing is, Trump's is the better story. It's like the end of the movie Life of Pi, where the lone survivor of a shipwreck has the choice of whether to tell the good story or the bad story. One will destroy you, and one will inspire you. It's used as a metaphor for religion, but it works here, too.Trump's is the better story because he's a better storyteller. For all of Trump's obvious gifts, that one has served him the best. He's mastered it for his entire life, starting all the way back in high school, where he would just stand in front of a crowd and tell stories.For the past ten years, many people have needed to believe in Trump's story, many of them discarded and forgotten by the empire. Over time, more and more people were drawn in as each side played its role. The Left hunted Trump down and cast themselves as the villains. How could they have ever thought that was a winning strategy?That is what I find most inspiring about Trump. That's why so many of his supporters remain loyal to him and fiercely defend him, even when — especially when — he makes mistakes.In 2020, I was in a very dark place. I was caught up in the so-called #resistance. I believed Putin had Kompromat on Trump. I believed it all. I read all of the books. I hung on to every word Rachel Maddow said.But things would change in those four years. It would become dystopian on the Left. I would feel the mob's wrath one too many times just for speaking out and pushing back about things I knew to be true. I also had no other social life except Twitter and Facebook during lockdowns, where the daily ritual of hate aimed at Trump, his staff, his family, and his supporters began to feel like poison.I didn't want to be a part of it. If, for no other reason, I'd been the target of hate for so long, and I empathized with them. Worse, I knew I was wrong to dehumanize a whole group of people, no matter what the excuse was. Dehumanizing them had already led to violence on the streets before, during, and after Trump's first term.I knew enough history to have asked myself the question more than once: What would you do? What would you do in Salem in 1692? What would you do in Germany in the 1930s? What would you do in the Jim Crow South? I'm not comparing them. I'm just saying the mechanism is the same, and the person I wanted to be, and believe I am, is someone who would not go along with it, especially since my life wasn't in danger.Thus began my journey over to Trump's side of things. I wanted to know whether our version of Trump was true. Was he a threat to Democracy? Was he a virulent racist and “white supremacist”? If I watched enough of his rallies, I might find the smoking gun. Maybe I would have enough proof to justify everything we did to try to destroy him. But that never happened.In 2020, he had survived COVID and was out doing five rallies a day, flying in on a helicopter, circling the crowd overhead, then greeting them with a handful of red hats, tossing them to the crowd. And I watched every single one of his rallies. And as time went on, something happened to me. I guess you could say I was like the Grinch.My heart grew because I saw people who had every reason to be miserable, full of hate, and resentful, as the media describes them, but who were none of those things. They were happy. They were joyful. Trump made them laugh. They danced. It was one big party—a glowing oasis of fun amid an endless, dark winter on the Left.I'll never forget hearing Trump at a rally in Miami in the pouring rain. I remember thinking, This is amazing. The press will never cover this. They could never. They could never write about people who loved Trump that much, to stay out there as the rain pounded down.But of course, that was the story. That was the real story. That was the truth. What I saw in Trump and MAGA is what Tucker Carlson saw in this often-played video summarizing the Trump movement just before the 2020 election.Trump speaks a language called Normal American. It's one we on the Left abandoned long ago. After years of curating our language to be pristine, inoffensive, soft, and kind, we became too fragile to speak Normal American.But Trump can talk to anyone, especially normal Americans. That's why he could fly to so many different states, land anywhere - a McDonald's, a pizza joint, or even East Palestine, Ohio, and fit right in.Normal American can sometimes be offensive. Some of us still speak it when we think no one is watching or listening. To the Left, that means we use all of the slurs that prove we are an ist or a phobe. But no, it just means the occasional dirty joke, or talking like we all used to, without fear and at ease.What I love so much about Trump is his persistent, unshakable optimism. He refused to accept the Left's rewrite of him. They could never destroy Trump because they weren't fighting the real guy; they still aren't. Their ridiculous “No Kings” protest on his birthday is a fantasy about someone they invented who doesn't exist in real life.They don't see the Trump we all see—the guy who faced them down for a decade and triumphed. Four years of attacks, framed as a Russian asset, impeached twice, indicted four times, convicted of a felony, called a racist, a rapist, a fascist, a dictator, a criminal, a felon, Hitler and now — a King. A guy who was almost assassinated twice, took a bullet, survived it, then got on stage just days later to give a 90-minute speech. You bet that's the better story.In all of that time, the Democrats never did the one thing they would have to do to defeat Trump: offer the people something better. The reason they don't is that they can't. They want America back the way it was before Trump. But it's never coming back because we, the people, voted for it never to come back.If they think they can somehow force those who speak Normal American to ever listen to them over Trump, they're fooling themselves. They can throw as many tantrums as they want, but that won't fix who they are. That's why they lost the election. It's never been about Trump. It's always been about them.If anything, Trump was the guy who spelunked into our Doomsday Bunker like SEAL Team Six to get us the hell out of there. You can throw all the lawn signs at us you want. We're not going back.What watching Trump for five years has taught me is just how weak so many of those I once saw as heroes really are. They've never looked so small as they do right now, never so petty as all of them cosplaying oppression just because they lost an election and can't face the humiliation. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sashastone.substack.com/subscribe

Jenn Should be a PI 06/13/25

Podcast: LAS NOTICIAS CON CALLE DE 12 DE JUNIO DE 2025 - LUMA responde a guerra, asegura que en sus cuentas le deben casi mil millones, Czar de energía dice que es falso - T11 - Irán e Israel a punto de guerra tras colapsar negociaciones y Trump pide a familias empezar a salir de zona - FT- Católica compra UCB en más cambios de centros educativos a punto de cerrar - El Nuevo Día - Vienen más APP - El Vocero - Gobierno anuncia programa con bancos para que jóvenes compren casas, los bancos y cooperativas no saben nada - El Vocero- Cada vez más viejos los padres boricuas - Metro - A sobre 300 mil la vivienda de interés social en PR - Primera Hora- Tras caso de intento de violación de sujeto liberado tras violar enmendarán la ley - El Nuevo Día- Madres indocumentadas están autorizando custodias para evitar que sus hijos pierdan al deportarles a ellas - El Nuevo Día - Crearán albergue de mascotas en edificio abandonado de PRIDCO para municipios - El Nuevo Día - JGo dice que no dará info de menores en casos de deportación a menos que haya orden judicial - El Nuevo Día- Enfermeros en protesta hoy - El Nuevo Día - Se le cae caso a federales, libre de todo Velázquez Piñol aunque pudieran volver a acusarlo - El Vocero - Serpientes no son un emergencia dice Recursos Naturales - El Vocero - Trump vuelve con las benditas tarifas en dos semanas informó - FT- Senadores plantean empuje de resistencia contra el proyecto de Trump y su presupuesto - FT- Sale propuesta para resolver tranque republicano cortándole poder al FED - Bloomberg - Inversionistas huyen al oro ante incertidumbre de mercados y Euro pasa a tercer plano - Financial Times - Socavón en Rexville con camión de basusra - Noticentro - Se estrella avión en India poco después de despegar - India Times Siempre innovando y con los mejores beneficios, MCS PersonalDirecto te ofrece cubiertas accesibles para que cuides de tu salud y la de los tuyos.Con una amplia red de proveedores de más de 15,000 médicos de libre selección.Reembolso de hasta $40 mensuales por membresía a un gimnasio o por un entrenadorpersonal debidamente certificado. Asistencia en el hogar para servicios de cerrajería,plomería y electricidad de hasta $350 por evento hasta 4 veces al año.¡Únete HOY a la gran familia de MCS!¡Salud que completa tu vida! Llama al 787.945.1259 y oriéntate.

Co-hosts Robin Renée and Wendy Sheridan head back to the Blanket Fort this time to regroup, check in, and hide out. But there's not much actual hiding to be had from the firehose of news and unrest. They catch up on the intentional ways they each are staying sane through the mayhem -- painting, gardening, exercising, immersing in fiction, and curating the news for personal consumption among them. ICE raids, the National Guard, and the chaos stoked in Los Angeles can't be ignored, nor can thinking about ways to protest in the streets and elsewhere, wishing for the least violence and the greatest impact. They think about the role of their creative works and consider writing some "political earworms." Wendy might revive and complete one of her old songs, "Men of Stone."         For the Timelime Cleanse that starts the show, Wendy is happy with her newly painted art storage box and Robin describes a jello mold drag relay race that was pure joy. The biggest Pièce de Résistance this time around is the upcoming No Kings Day on June 14th, while the Pope seems to have scheduled some counterprogramming of his own. Wendy reads from On Tyrrany followed by a discussion and Robin reads a new brief reflection/response piece, "Why So Much Pride?" Things to do: Join a June 14th No Kings Day protest: Indivisible, FiftyFifty.one/events. Stay safe and know your rights. Listen to Episode 172 for Anji Marth's ideas for being prepared and helpful at protests. Read On Tyrrany: Twenty Lessons From the Twentieth Century by Timothy D. Snyder. Watch "LA protests LIVE: View from Los Angeles" https://www.youtube.com/watch?v=cMcCbwLCAYc Listen to the Saved By Zero show by Robin (DJ Andrew Genus) on Radio PVS and Mixcloud. Check out Wendy's stuff on Etsy. Jam out to this internet classic. https://www.youtube.com/watch?v=PuWVgVkMiHE    

Di vê bûletene de: Wezîrê Parastinê Richard Marles gumanên li ser siberoja peymana sêalî ya AUKUS kêm dike... Balyozê Îsraîlê li Australya dibêje sepandina cezayan li ser du wezîrên Îsraîlî 'nayê pejirandin'… Û di avjeniyê de, Piştî roja sêyemîn a Ceribandinên Australya li Adelaide, hin rûyên nû di tîmê Dolphins de hene, ew nûçeyana û nûçeyên din di bûlentenê de hene.

Učitelj smučanja živi v mestu Bariloche nedaleč od Čila. Zime so zadnjih nekaj let še vedno radodarne s snegom, zato se v tem času že pripravlja na sprejem prvih gostov na smučišču Cerro Catedral. Po večini so to premožnejši občasni smučarji iz Buenos Airesa, Sao Paula in Ria de Janeira. V Argentini sicer dva od petih prebivalcev živita pod pragom revščine. Razlike so opazne in se v času predsednika Javierja Mileia ne zmanjšujejo. Se je pa nekoliko umirila inflacija na letni ravni.Zapiski: Marko Žnidaršič na Facebooku, smučarsko središče Catedral Alta Patagonia, Argentina inflation seen slowing to 28.6% by year-end. Poznate potencialnega sogovornika ali sogovornico za epizodo Globalne vasi? Pišite na nejc.jemec@rtvslo.si

Send us a textGet ready to sleuth through secrets, lies, and… reality TV scandal? In this week's episode of Hallmark Mysteries and More, Andrea and Eric break down episode 4 of Private Eyes Season 1: “The Devil's Playground.” It's a fun, fast-paced mystery set against the surprising backdrop of the Toronto Islands (yes, they're real!).We dive into why this might be the best Private Eyes episode so far—complete with character-driven storytelling, smart red herrings, emotional depth, and a delightfully unexpected twist involving two very familiar HGTV-style “hosts.”Along the way, we explore Angie and Shade's evolving chemistry, the emotional father-daughter arc, and how this series continues to blend comedy, romance, and intrigue with Hallmark-level charm.

C'est une nuit calme de la mi-juillet 1709 à Versailles : le vieux Louis XIV observe une cassette scellée. Il y a quelques jours, le monarque a ordonné la destruction de l'entièreté des archives royales concernant le plus grand scandale de son règne. Trente ans après la fin de l'affaire des poisons, le souverain souhaite plonger cette histoire dans un “éternel oubli.” Empoisonnements en série, sorcellerie, messes noires, rebondissements sordides et secrets d'État… Avec 442 personnes inculpées issus de toutes les strates de la société et des victimes innombrables, l'affaire qui nous occupe aujourd'hui a durablement marqué l'histoire de la justice française.C'est la fin d'une époque pour Athénaïs de Montespan. Pièce après pièce, elle voit son mobilier luxueux quitter ses appartements du château de Versailles. Une partie rejoint le réduit qu'elle occupera désormais dans les soupentes du palais. Difficile de croire à cet instant que quelques années plus tôt, la belle marquise régnait en maître sur le coeur du Roi Soleil. Et, par lui, sur toute la Cour de Versailles.

This week Mackenzie and Hanna invite the first PI guest on the show to share one of their own stories! The first PI guest is Austin, a nine-year veteran whose toolkit spans family-law digs, criminal-defense surveillance, insurance-fraud exposés and cutting-edge open-source sleuthing. He pulls back the curtain on what it really takes to trail a suspect—long hours in a lobby, split-second decisions on whether to dash inside or stay hidden, and even the pros and cons of facial-recognition software like PIMeyes. You'll get Austin's top safety hacks for vetting dates (free and low-cost background-check resources you can use tonight) and discover why a seemingly innocent Memorial Day beach trip ended with an all-too-public, trunk-wide rendezvous in a cherry-red Porsche.Click here to join our Patreon! For only $5 a month you will get 2 extra episodes a month, monthly virtual live events, and access to our community page. And now for $9 a month you can get all of that, plus ad free episodes!If you've been dogfished and want to share your story on the show, email investigate@thedatingdetectivespodcast.com or contact us through our website using this linkTake control of your data today. Get 20% off your DeleteMe plan by visiting joindeleteme.com/datingdetectives and using the promo code TDD at checkout. This episode of The Dating Detectives is sponsored by Simpli Pop. Find your favorite new prebiotic soda at CokeURL.com/SimplyPop.***The following Program contains names, places and events that have been anonymized or fictionalized for the purposes of protection and safety. The following Program is provided for entertainment purposes only and any commentary from the hosts are strictly conjecture and should not be held as making any definitive statements about the truth or identity of any particular individuals or circumstances.If you or a loved one are involved in an abusive relationship, please call the National Domestic Violence Hotline at 1-800-799-7233 for support.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cindy is a serial entrepreneur and champion for women's health and wealth. Over her 25+ year career in healthcare, she's built and sold two companies for over $1 billion, including Sprout Pharmaceuticals, where she launched Addyi, the first prescription drug for women's low libido and what many people call the “female Viagra.” She's now the founder of The Pink Ceiling, where she invests in and mentors women-led businesses breaking barriers in health, wellness, and beyond. In this week's episode, Cindy shares the lessons of building billion-dollar companies. She talks about why competence matters more than confidence, and how importance of taking the shot, even when you don't have all the answers. She shares how growing up constantly on the move taught her how to adapt quickly, build relationships, and embrace change — skills that became her foundation in business. She opens up about the emotional toll of entrepreneurship, the power of building a strong team, and why women need to talk more openly about pleasure, power, and money, and so much more.Disclaimer:ADDYI is for premenopausal women with acquired, generalized hypoactive (low) sexual desire disorder who have not had problems with low sexual desire in the past, and who have low sexual desire no matter the type of sexual activity, the situation or the sexual partner. The low sexual desire is troubling to them and is not due to a medical or mental health problem, problems in the relationship or medicine or other drug use. ADDYI is not for use in men or to enhance sexual performance. Your risk of severe low blood pressure and fainting is increased if you drink 1-2 standard alcoholic drinks close in time to your ADDYI dose. Wait at least 2 hours after drinking before taking ADDYI at bedtime. Your risk of severe low blood pressure and fainting is also increased if you take certain prescription, over the counter or herbal medications, or have liver problems. Low blood pressure and fainting can happen when you take ADDYI even if you don't drink alcohol or take other medicines. Do not take if you are allergic to any of the ingredients in ADDYI. Allergic reactions may include hives, itching or trouble breathing. Sleepiness, sometimes serious, can occur. Common side effects include dizziness, nausea, tiredness, difficulty falling asleep or staying asleep and dry mouth. See full PI and Medication Guide, including Boxed Warning at addyi.com/pi or call 844-PINK-PILL.In this episode, we'll talk to Cindy about:* Competence is the key to overcoming challenges. [03:04]* Disruption can be a catalyst for growth. [08:29]* The power of curiosity during Cindy's college years. [11:52]* Lessons from Cindy's first business. [22:45]* Cindy's mission to empower women. [28:43]* Getting rejected by the FDA. [33:37]* Women on pleasure and health. [43:47]This episode is brought to you by beeya: * Learn more about beeya's seed cycling bundle at https://beeyawellness.com/free to find out how to tackle hormonal imbalances. * Get $10 off your order by using promo code BEHINDHEREMPIRE10Follow Yasmin: * Instagram: https://www.instagram.com/yasminknouri/* Stay updated & subscribe to our newsletter: https://www.behindherempire.com/Follow Cindy: * Instagram: https://www.instagram.com/cindypinkceo/* Website: https://thepinkceiling.com/ Hosted on Acast. See acast.com/privacy for more information.

In a personal injury case, the plaintiff's lawyer must rely on witnesses to perform. In a bad-faith case, their job is educating the jury about the rules that insurance companies must follow. That's how Ricardo Echeverria describes the two areas of his practice at Shernoff Bidart Echeverria. With hosts Ben Gideon and Rahul Ravipudi, he explains that he started his career focusing on PI but that evolved over the years to litigating bad faith cases. “They are definitely different kinds of cases and a different approach to cases altogether,” he says. Tune in for Ricardo's insights about how he advocates for fire victims who are under-insured and why he'd "go back to milking cows" before representing insurance companies.Learn More and Connect☑️ Ricardo Echeverria☑️ Shernoff Bidart Echeverria on LinkedIn | Facebook | X☑️ Ben Gideon | LinkedIn | Facebook | Instagram☑️ Rahul Ravipudi | LinkedIn | Instagram☑️ Panish Shea Ravipudi LLP on LinkedIn | Facebook | YouTube | Instagram☑️ Gideon Asen on LinkedIn | Facebook | YouTube | Instagram☑️ Subscribe: Apple Podcasts | Spotify Produced and Powered by LawPodsSponsored by

PODCAST: Las noticias con calle de 3 de junio de 2025 - La colosal nube del Sahara sobre PR - SNMTe cobran más por viajar solo si vuelas en estas líneas aéreas - Thrifty Traveler Buscan agentes como loco para cuadrar cuarteles vacíos - Primera HoraHumana de salida de PR - Cuarto PoderSobrevivientes de violencia de género optan por armarse - El Nuevo DíaArajet empieza con vuelos de RD a PR - El Nuevo Día Tribunal federal autoriza poner X en vez de Femenino o Masculino en certificado de nacimiento - El Nuevo Día Velázquez Piñol pide desestimación contra él por su caso con Julia Keleher - El Vocero Gobernadora despreocupada por reunión de los tres golpes eon Pierluisi - El Nuevo Día Referir a ASES supuesto descuadre presupuestario - El Nuevo DiaVienen cambios en el presupuesto - El Nuevo Día Congresistas investigan cancelación de mega barcazas de energía - El Nuevo DíaGobierno cobra por inspecciones que no hace y hasta 4 millones - El Nuevo Día UPR recibe cortes de 20 millones por fondos de investigación - El Nuevo DíaPR depende tres veces más de fondos federales que en los estados - Junta A enmendar el presupuesto de ASES otra vez por 109 millones de descuadre - El Vocero 80% de las motoras que operan en PR están sin marbete - El Vocero Mil millones por la represa Guajataca para agua a trescientos mil - El Vocero Velázquez Piñol pide desestimación contra él por su caso con Julia Keleher - El Vocero Piden posponer otra vez el caso de una de las hermanas Falcón en tema de AAA en caso Anaudi Hernández - El Vocero - Matan sujeto que iba an scooter en carretera indebidamente - El Vocero Pausan fondos federales para educación vocacional aunque Trump dice que eso es lo que quiere fomentar - Noticel Llegamos a 3070 megavatios de demanda de energía y todavía no han ocurrido los calores esperados - Metro Siempre innovando y con los mejores beneficios, MCS PersonalDirecto te ofrece cubiertas accesibles para que cuides de tu salud y la de los tuyos.Con una amplia red de proveedores de más de 15,000 médicos de libre selección.Reembolso de hasta $40 mensuales por membresía a un gimnasio o por un entrenadorpersonal debidamente certificado. Asistencia en el hogar para servicios de cerrajería,plomería y electricidad de hasta $350 por evento hasta 4 veces al año.¡Únete HOY a la gran familia de MCS!¡Salud que completa tu vida! Llama al 787.945.1259 y oriéntate.