Podcasts about caloric restriction

In this episode, we sit down with Dr. Matthew Dawson, the founder and CEO of Wild Health, and leader in genomics-based precision medicine. Dr. Matt breaks down what precision medicine truly means--how it goes beyond traditional healthcare to create highly personalized plans based on your unique genetic blueprint and blood work. We explore some of the most important genes to assess for optimizing health, performance, and longevity, including the ApoE gene. He shares powerful insights into the future of medicine and why understanding your genetics is crucial for extending healthspan. Plus, we open up about our own personal Wild Health test results and how they've shaped our individual wellness journey. This conversation is packed with actionable insights you won't want to miss!Dr. Matthew Dawson is the founder and CEO of Wild Health, a genomics-based precision medicine company, and the CEO of TruDiagnostic, an epigenetics testing lab. He has authored two textbooks, published over two dozen studies, lectured in over 20 countries, and won national awards for education and innovation. His passion is unlocking the secrets of the genome and epigenome and using them to optimize health and maximize healthspan. He lives in the woods with his wife, four children, and two dogs.SHOW NOTES: 0:31 Welcome to the show!3:57 Dr. Matt Dawson's Bio4:40 Welcome Dr. Matt to the show!5:14 What is “Precision Medicine”?7:14 Your genes are not your destiny11:09 Renee's experience with Bulletproof coffee11:38 MTHFR & Homocysteine12:43 Combining lab work with genetics17:24 Alzheimer's genetics20:32 What to do for APOE-3/422:56 Biomarkers for optimal health 24:28 Can you change your sleep chronotype?28:26 Genes for telomere length31:37 *ALIGN MAT*33:16 *PIQUE TEA*35:27 Boosting BDNF37:30 Something new about HbA1C!39:47 FOXO3 Gene for Longevity43:40 Blue Zones & social connection45:12 Testing Biological Age49:08 Caloric Restriction for Longevity51:42 The perfect diet for your genes53:25 Comparing macro tolerances57:37 Wild Health reports 59:12 Coming soon for Precision Medicine!1:04:16 His final piece of advice1:04:56 Thanks for tuning in!RESOURCES:Website: wildhealth.com - discount code: BIOHACKERBABESInstagram: wildhealthmdLinkedIn: Wild HealthMy Align Mat - discount code: BIOHACKERBABES to save $250Pique Tea - Save $ with this link!Puori - Save 20% with discount code: BIOHACKERBABESEffecty - Save $50 with discount code: BIOHACKERBABESOur Sponsors:* Check out Effecty and use my code BIOHACKERBABES for a great deal: https://www.effecty.com* Check out Puori: https://Puori.com/BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Biohacking for Longevity: Extending Your Health Span. In this episode of "Leyla Weighs In," registered dietician and nutritionist Leyla Muedin discusses the concept of biohacking and its potential to extend lifespan and health span. Leyla explores various biohacking strategies such as diet optimization, regular physical activity, stress management, enhancing sleep quality, and maintaining strong social connections. She emphasizes the importance of epigenetics, targeted lifestyle changes, and advanced medical interventions like stem cell therapy. You will learn practical biohacking tips, including the benefits of intermittent fasting, the significance of exercise, and how to use wearable technology for health tracking. Leyla also highlights the role of supplements and personalized nutrition in promoting longevity, alongside maintaining good dental health and a sense of purpose. Through these combined efforts, Leyla aims to inspire listeners to not only live longer lives but to enjoy better health and vitality.

Want to live longer and feel better? Dr. G breaks down the top 5 science-backed strategies to increase longevity and boost your health. From strength training to cardiovascular fitness, social connections, and better sleep, this is your ultimate guide to aging well. Plus, learn about key supplements that can support your journey! #health #antiaging #wellness  ==== Thank You To Our Sponsors!  Timeline  Visit https://timelinenutrition.com/drg and use code DRG to get 10% off BiOptimizers Go to https://bioptimizers.com/drg and use promo code DRG10 to get 10% any order.  ==== Timestamps: 00:00:00 - Introduction: The Importance of Muscle Mass and Longevity 00:01:00 - The Five Evidence-Based Ways to Extend Your Life 00:02:33 - #5: Strength Training for Longevity 00:09:36 - #4: Sleep Quality and Duration 00:11:36 - #3: Caloric Restriction and Fasting 00:15:14 - #2: Social Connection and Purpose 00:18:26 - #1: Cardiovascular Fitness 00:20:14 - Conclusion: Taking Control of Your Longevity

What does true health look like? In this episode, I sit down with Justin Nault, health coach and founder of Clovis, to break down the biggest myths in nutrition and fitness while sharing practical steps to transform your health.We discuss why reproductive ability is a key marker of health, how caloric restriction isn't the answer, and why community and personal growth play a bigger role in well-being than you might think. Justin also shares insights on fasting for metabolic health, the dangers of seed oils, and why prioritizing protein intake is crucial for optimal wellness.Plus, Justin opens up about his personal journey, including the impact of his niece Savannah's health struggles and his own experiences with dry fasting and plant medicines. Whether you're looking to optimize your hormonal health, metabolism, or overall well-being, this episode is packed with science-backed insights and actionable advice you can implement today!What We Cover in This Episode:

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens.Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves.The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections.Guest-at-a-Glance

Discover the five essential factors that contribute to a long, healthy life. From the power of community to caloric restriction, deep sleep, sunlight, and core strength, this episode uncovers research-backed strategies to enhance your longevity. Learn how small daily changes can lead to a vibrant, fulfilling life at 100 and beyond! 5 KEY TAKEAWAYS Community is key: Strong social connections and a sense of belonging are crucial for longevity. Caloric restriction boosts lifespan: Eating less without malnutrition activates longevity pathways like autophagy. Quality sleep detoxifies the brain: Deep sleep promotes growth hormone production and clears harmful waste. Daily sunlight resets your body clock: Proper exposure to natural light optimizes circadian rhythms and overall health. Core strength predicts longevity: The ability to get up from the floor without assistance is linked to a longer life. FEATURED PRODUCT: Mitochondriac Mitochondriac is packed with resveratrol, a powerful antioxidant that mimics the effects of caloric restriction and promotes mitochondrial biogenesis. This essential supplement supports cellular energy, fights oxidative stress, and enhances overall longevity—perfect for those looking to live to 100! TIMESTAMPS 00:00 START 02:15 The first secret: The power of community 10:40 How genetics influence only 20% of lifespan 15:30 What we can learn from centenarians and Blue Zones 21:50 The second secret: Caloric restriction for longevity 30:15 How fasting triggers autophagy and mitochondrial health 38:10 The third secret: Why sleep is crucial for living to 100   RESOURCES MENTIONED "How to Live to 100" – Research on longevity and centenarians https://www.today.com/health/aging/how-to-live-to-100-rcna104086 "Life Advice from Centenarians" – AARP insights on aging well https://www.aarp.org/health/healthy-living/info-2023/life-advice-from-centenarians.html "Live Healthy to 100" – OSU study on aging factors https://alumnimagazine.osu.edu/story/live-healthy-100 "Caloric Restriction and Longevity" – NIH research on fasting https://pmc.ncbi.nlm.nih.gov/articles/PMC9036399/ "The Okinawan Secret to Longevity" – Blue Zones research https://www.bluezones.com/2020/07/why-the-okinawan-practice-of-sitting-on-the-floor-is-linked-to-health-mobility-and-longevity-how-you-can-practice-it-at-home/

In this in-depth video, Connor shares his personal journey of losing 135 pounds in approximately seven and a half months, primarily through fasting. He addresses and debunks ten common myths surrounding fasting, providing both personal insights and scientific explanations:Myth: Fasting Destroys Your Metabolism - Connor explains that contrary to popular belief, fasting can actually increase metabolism by about 10%, rather than decreasing it, which is often the case with caloric restriction diets.Myth: Fasting Causes Muscle Loss - He counters this by explaining that fasting activates hormones like growth hormone, which help preserve muscle mass while the body uses stored fat for energy.Myth: Fasting Leads to Constant Hunger and Binging - Connor describes how hunger comes in waves and diminishes over time during a fast. He emphasizes understanding hunger as a temporary feeling rather than an ongoing state, and highlights strategies to manage potential binging post-fast.Myth: Fasting Leads to Nutrient Deficiency - While you might lose some minerals through increased urination, Connor suggests supplementing with magnesium, potassium, or salt if necessary, but stresses that the body is good at regulating these needs.Myth: Fasting is Equivalent to Starvation - He clarifies the difference between fasting and starvation, noting that those who fast have food available and are making a choice, unlike starvation where food is unavailable.Myth: Fasting Causes Low Blood Sugar and Fainting - Connor explains that for healthy individuals, blood sugar levels are well-regulated during fasting, but advises those with health conditions or on medications to consult their doctors.Myth: Fasting Isn't Sustainable - Sharing his ongoing practice, Connor argues that fasting can be a sustainable lifestyle choice, detailing his approach of not eating for several days each week and occasionally engaging in longer fasts.Myth: Fasting Depletes Your Energy and Mental Focus - He describes how fasting can actually enhance mental clarity and energy by freeing up resources usually used for digestion.Myth: Fasting is Only for Weight Loss - Beyond weight loss, Connor discusses benefits like autophagy (cellular repair), potential for scar and loose skin reduction, and overall health improvement.Myth: Fasting is a New Fad Diet - He points out the historical and religious significance of fasting, dismissing the notion that it's a modern trend.Youtube Channels:Conner with Honor - real estateHome Muscle - fat torchingFrom first responder to real estate expert, Connor with Honor brings honesty and integrity to your Santa Clarita home buying or selling journey. Subscribe to my YouTube channel for valuable tips, local market trends, and a glimpse into the Santa Clarita lifestyle.Dive into Real Estate with Connor with Honor:Santa Clarita's Trusted Realtor & Fitness EnthusiastReal Estate:Buying or selling in Santa Clarita? Connor with Honor, your local expert with over 2 decades of experience, guides you seamlessly through the process. Subscribe to his YouTube channel for insider market updates, expert advice, and a peek into the vibrant Santa Clarita lifestyle.Fitness:Ready to unlock your fitness potential? Join Connor's YouTube journey for inspiring workouts, healthy recipes, and motivational tips. Remember, a strong body fuels a strong mind and a successful life!Podcast:Dig deeper with Connor's podcast! Hear insightful interviews with industry experts, inspiring success stories, and targeted real estate advice specific to Santa Clarita.

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Subscribe to our channel: https://www.youtube.com/@optispan In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological resilience shapes our responses to stress, the importance of hormesis in health, and the role of brown fat in metabolism. We also discuss the impact of fasting, caloric restriction, and the relationship between mitochondrial health and aging. 00:00 - Introduction to Cold Plunge and Resilience 03:33 - Types of Stress & Responses 14:18 - Mitochondrial Health, Caloric Restriction & Metabolism 23:05 - Cold Therapy and Brown Fat 54:10 - Conclusions & Final Thoughts Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Hannah Went, co-founder of TrueAge, a leading omics age company. They discuss the significance of epigenetics in understanding biological age, the predictive power of various aging clocks, and the advancements in measuring biological age through multi-omics approaches. The conversation also covers the impact of interventions like caloric restriction on aging metrics, the Dunedin Pace as a new metric for biological aging, and the complexity of aging as a multifactorial process. Went shares insights into the future of epigenetic research and the importance of actionable insights for health optimization.    For the audience:   * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/         Takeaways    * Epigenetic markers can predict chronological age with high accuracy.  * GrimAge is a new clock that estimates mortality risk.  * Multi-omics approaches provide a comprehensive view of aging.  * Caloric restriction significantly impacts biological age.  * Dunedin Pace measures the rate of biological aging.  * Aging is a complex, multifactorial process.  * Understanding what tests do not measure is crucial.  * New biomarkers for aging are being developed and validated.    Chapters    00:00 Introduction to Omics Age and TrueAge  04:12 The Evolution of Epigenetic Clocks  07:55 Integrating Lifestyle Factors in Omics Age Testing  10:14 Predicting Disease Risk and Mortality with Omics Age  13:27 Reversing Biological Age with Interventions  16:42 Actionable Insights from Omics Age Testing  26:30 Exploring the Impact of Caloric Restriction on Aging  29:08 Understanding the Dunedin Pace as a Measure of Biological Aging  33:32 The Complexity of Aging and the Limitations of Single Metrics  35:24 Epigenetic Biomarker Proxies: A Comprehensive Approach to Aging  43:59 Cell Reprogramming and its Implications for Aging  49:24 Goodbye    Learn more about TruAge and/or contact them:  Email: hannah@trudiagnostic.com   Website: https://www.trudiagnostic.com/   Facebook: https://www.facebook.com/TruDiagnostic/   Instagram: https://www.instagram.com/trudiagnosticofficial/   X: https://x.com/TruDiagnostic   YouTube: https://www.youtube.com/c/trudiagnostic   TikTok: https://www.tiktok.com/@trudiagnostic?is_from_webapp=1&sender_device=pc   LinkedIn: https://www.linkedin.com/company/trudiagnostic/     Reach out to us!   Website: https://gladdenlongevity.com/    Email: podcast@gladdenlongevity.com    Facebook: https://www.facebook.com/Gladdenlongevity/   Instagram: https://www.instagram.com/gladdenlongevity/?hl=en    LinkedIn: https://www.linkedin.com/company/gladdenlongevity   YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw   

LAST DAY TO SAVE! TONE COLLAGEN is NOW OUT! Check it out HERE & get 15% OFF for the LAUNCH with the code KG15!  Hi friends! This episode is about New Studies: Pre-Workout Carbs vs Fasted Workouts, Autophagy & Fat Loss - Fasting VS Caloric Restriction, Can Women Gain Muscle & Strength as Much As Men & More! See the study HERE Jump to the start of studies at 27:05 Get 20% off the Tone LUX Crystal Red Light Therapy Face Mask with the code VANESSA Get 20% off Energybits with the code KETOGIRL HERE Everyone is loving Tone Protein! Scientifically formulated based on the science to support Muscle Protein Synthesis.  Click Here to Check it out! Join the Community! Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ Thank you to our sponsor:   Bioptimizers Magnesium Breakthrough is one of the only supplements I take with me when I travel as it is so important to me! Save 10% OFF with the code VANESSA at bioptimizers.com/vanessa   - This podcast content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and personal health questions. Prior to beginning a new diet you should undergo a health screening with your physician to confirm that a new diet is suitable for you and to out any conditions and contraindications that may pose risks or are incompatible with a new diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A new diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl podcasts & videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

Why do drugs like Ozempic work? In this episode of Piloting Health, Dr. Frank Dos Santos joins me once again for an in-depth look at the most talked-about drugs on the market right now: GLP-1 agonists.We break down exactly why the drugs cause weight loss, but also how that weight loss can lead to a reduced change of certain types of diseases. What is it about caloric restriction that can help stave off disease?  In this vein, we also talk intermittent fasting and I even espouse my theory that the body encourages fasting when combatting certain types of cancer. It goes without saying that any decision to begin any type of drug or medical regiment needs to be discussed with your physician, so we're not advocating for any individual to begin GLP-1 agonists or fasting but, in general, the results we're seeing from caloric restriction seem to be very positive in many circumstances.  In this episode, Dr. Dos Santos and I break down exactly why.To follow Dr. Dos Santos, you can find him on Instagram:@drfrankdossantosFollow Dr. Bob Hariri on his platforms here:Web: www.pilotinghealth.comInstagram: https://www.instagram.com/drbobhariri/X: https://twitter.com/DrBobHaririTikTok: https://www.tiktok.com/@pilotinghealthLinkedIn: https://www.linkedin.com/in/drbobhariri/

Send us a textIn this fascinating episode, I sit down with Victor Sagalovsky, co-founder and CEO of Lightwater Scientific, a trailblazer in the world of deuterium depletion and its transformative impact on human health. Victor's passion for understanding the quantum biology of water has led him to pioneer a revolutionary approach to longevity, energy optimization, and overall vitality through deuterium-depleted water. During our conversation, Victor dives into the science behind deuterium depletion and how it enhances mitochondrial function, oxygen utilization, and even helps to slow the aging process. He shares insights into the intricate relationship between water, energy production at the cellular level, and how managing deuterium levels can unlock profound benefits for performance, recovery, and longevity. This episode is a must-listen for anyone curious about the cutting-edge intersection of water science, quantum biology, and longevity. Whether you're a biohacker, health enthusiast, or just seeking to elevate your wellness journey, Victor's expertise offers a unique and powerful perspective on how to use deuterium-depleted water as a tool for optimized health and performance. Tune in to discover how to take your health to the next level with insights that are both deeply scientific and highly actionable.Key Points From This Episode:00:04:24 - Introduction to Victor and Lightwater Scientific00:05:10 - Understanding Deuterium Depleted Water (DDW)00:06:42 - The Science Behind Energy Production00:12:33 - The Impact of Deuterium on Aging00:22:02 - The Process of Creating DDW00:35:36 - Caloric Restriction and Deuterium00:49:10 - Future Possibilities with Deuterium Management01:00:24 - Discovering the Self Through Water01:22:03  - Understanding Water's Role in Mineralization01:36:01 - Setting a Baseline for Deuterium Levels!Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://calendly.com/andrespreschel/intro-call-with-andresLinks Mentioned in Today's Episode:Click HERE to save on BiOptimizers MagnesiumSpecial Offer:Get 10% off your first order with the discount code: PHYSIO.Also receive 20% off your Deuterium Tests.PeopleVictor SagalovskyLinkedIn ProfileDr. Laszlo BorosOfficial WebsiteDr. Gerald PollackOfficial WebsiteDr. Jack KruseOfficial WebsitePlacesLightwater ScientificOfficial WebsiteWater SymposiumWater Symposium Official WebsiteBooks and References"The Fourth Phase of Water" by Dr. Gerald PollackBook on AmazonDeuterium Test KitDeuterium Test WebsiteSupport the show

In this conversation, Kayla Barnes and JJ Virgin discuss women's health, fitness, and aging. They debunk myths about women and weightlifting, emphasize the importance of strength training, and highlight the need to focus on the basics of health and fitness. They also discuss the impact of hormones on women's health, particularly during perimenopause and menopause. The conversation emphasizes the importance of managing stress, optimizing thyroid function, and working with a knowledgeable healthcare provider to address hormonal changes. In this conversation, Kayla Barnes discusses various topics related to women's health, including hormone replacement therapy (HRT), weight loss, bone health, and exercise. She emphasizes the importance of getting a DEXA scan to assess bone mineral density and body composition. Barnes also highlights the benefits of resistance training, high-intensity interval training (HIIT), and power training for women. She recommends incorporating creatine supplementation and tracking total body water to monitor muscle health. Overall, Barnes encourages women to prioritize their health and make informed choices to optimize their well-being. Certified Nutrition Specialist Board Certified In Holistic Nutrition®Certified Personal Trainer About JJ As a triple-board certified nutrition expert and Fitness Hall of Famer, JJ is a passionate advocate of nutrition's healing power and is mission driven to ignite a movement of women choosing to age powerfully.  After decades of watching women strive to shrink themselves, JJ is urging women to step into their power—physically and personally. Using her principles of powerful aging, she inspires women to get strong, get bold, and get what they want in life.  She embodies her philosophy as both a legendary personal trainer and the founder of 2 multimillion-dollar businesses: her personal brand and the Mindshare Collaborative, the most influential professional community in health, having propelled more New York Times bestsellers, PBS specials, and 7 figure brands than any other community. Chapters 00:00 Introduction and Debunking Myths About Women and Weightlifting 08:10 The Importance of Strength Training for Women 19:20 Managing Hormonal Changes During Perimenopause and Menopause 27:05 The Role of Stress Management and Thyroid Function in Women's Health 33:29 Noticing Changes and the Importance of Hormones 36:50 Aging Powerfully and Embracing Personal Choices 37:19 Supporting Women and Avoiding Judgment 37:50 Hormone Replacement Therapy and Weight Loss 38:46 Factors Affecting Weight Loss and Body Composition 39:45 Starting with a Diet Audit and Tracking 41:14 Optimizing Protein Intake and Adding Nutrients 43:09 Caloric Restriction and Cycling 45:58 Protein Shaming and Prioritizing Protein 50:42 Exercising for Bone Health and Muscle Strength 52:58 Tracking Steps and Incorporating Bodyweight Exercises 56:21 Workout Options When Limited on Equipment 58:13 Training Frequency and Adjusting Based on Feel 01:02:31 Assessing Bone Health with DEXA Scans 01:03:26 The Benefits of Creatine Supplementation

Despite your best efforts to diet & shift your lifestyle, are you still lacking the results you hoped for? You may be unknowingly sabotaging yourself. This episode challenges common myths about keto, intermittent fasting, and caloric restriction, highlighting the critical role of metabolic flexibility & the stress impacts of certain diets. Discover the transformative effects of techniques like Buteyko breathing & CO2 therapy, & learn how your individual genetics and lifestyle choices shape your health. Meet our guest Jay is a health coach, independent health researcher, & the host of The Energy Balance Podcast. He has degrees in neuroscience & exercise physiology, & decided to forgo medical school after realizing that the conventional medical approach was not the solution to the health problems that so many of us face. After working through various conventional & alternative health paradigms & trialing countless diets, Jay came across the idea that cellular energy is the foundation of our health. Embracing this discovery, he now uses the Energy Balance approach to help men & women around the world maximize their cellular energy, optimize their health, & achieve freedom from low-energy symptoms & chronic health issues. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways The idea that fat burns cleaner than glucose is a misconception; in many cases, glucose burns more efficiently Short-term, ketones can boost metabolism, but long-term reliance on them can lower metabolic rates and promote fat storage Ketones are primarily used by the brain; the rest of the body relies on fat The brain, with its high metabolic needs, relies on glucose or ketones rather than fatty acids due to their more efficient energy production Carbon dioxide (CO2) has antioxidant effects, helping protect against reactive oxygen and nitrogen species, and is beneficial in low-oxygen states Chronic stress reduces CO2 levels, which can impact health Episode Highlights 11:17 Everything You Need to Know About Balancing Stress & Energy 20:16 The Truth About Caloric Restriction & Fasting 34:14 Fats VS Carbs (The Ultimatum) 42:26 Controversial Health Practices for Longevity 47:47 Surprising Health Benefits of CO2 & Oxygen Links Watch it on YouTube: https://youtu.be/14i898-9DCY  Full episode show notes: mindbodypeak.com/172 Connect with Nick on social media Instagram Twitter YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In today's episode, we explore common mistakes that can hinder your intermittent fasting success. Tune in to hear the common pitfalls I see all the time that can sabotage your fat loss and make you gain weight instead. Learn about simple but crucial changes to boost your metabolism and address insulin sensitivity issues. We'll discuss research on meal timing and its impact on your body's natural rhythms, and I'll share insights on optimizing eating schedules for better health outcomes. One major pitfall we'll address is how you approach your feeding windows. We'll delve into the importance of balanced eating and avoiding extreme behaviors that can sabotage your efforts. Discover strategies for maximizing the benefits of intermittent fasting, including its effects on cellular processes and hormone regulation. I'll also reveal my personal approach to managing hunger and maintaining muscle mass during fasting periods. Another crucial aspect we cover is the role of nutrition and hydration in your fasting routine. Learn why the quality of your food choices matters and how proper hydration can impact your results. I'll offer practical tips for staying on track and explain why consistency in your fasting schedule is essential for long-term success. Finally, we'll discuss the importance of micronutrients and how to ensure you meet your body's needs.  Join me as we uncover these essential insights and actionable tips to make your intermittent fasting journey successful and sustainable! FULL show notes: https://www.jjvirgin.com/fastingmistakes   7-Day Eat Protein First Challenge: http://jjvirgin.com/proteinfirst   Reignite Wellness™ Magnesium Body Calm: https://reignitewellness.com/products/magnesium-body-calm   Download my free Resistance Training Cheat Sheet: https://jjvirgin.com/resistance   Sugar Impact Diet: https://reignitewellness.com/products/sugar-impact-diet-paperback-book   Study: Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock: https://www.mdpi.com/2072-6643/13/5/1405   Study: Health Benefits of Fasting and Caloric Restriction: https://link.springer.com/article/10.1007/s11892-017-0951-7   Study: Synergistic effects of caloric restriction with maintained protein intake on skeletal muscle performance in 21-month-old rats: a mitochondria-mediated pathway: https://pubmed.ncbi.nlm.nih.gov/17142793/   Study: Brain–Gut–Microbiome Interactions and Intermittent Fasting in Obesity: https://ncbi.nlm.nih.gov/pmc/articles/PMC7916460/   Study: 10-Hour Eating Window Boosts Mood and Energy: https://neurosciencenews.com/intermittent-fasting-mood-25207/   Study: Assessment of water consumption during Ramadan intermittent fasting: Result from Indonesian cross-sectional study: https://pubmed.ncbi.nlm.nih.gov/35958263/   Study: Intermittent fasting 5:2 diet: What is the macronutrient and micronutrient intake and composition?: https://pubmed.ncbi.nlm.nih.gov/32199696/   Episode Sponsors:    Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products   Go to qualialife.com/VIRGINWELLNESS to try Qualia risk-free for up to 100 days and code VIRGINWELLNESS for an additional 15% off  

In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter's Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter's Supplements 02:18:46 Andrew's Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer

Episode Highlights With Hannah WentWhat biological age is and how we measure itUnderstanding cellular-based aging How we measure biological ageSprint speed and grip strength can be really loose indicators of biological ageUnderstanding epigenetic biomarker proxies and how to pull levers to improve your biological ageHow biological age is closely tied to all-cause mortality The biggest factors that affect biological age negatively or positively Not surprisingly, smoking and alcohol consumption are negative factors for biological ageDiet, physical activity, sleep, and stress make a big impact on biological ageHow caloric restriction comes into play for aging Pregnancy and menopause effects on aging Epigenetic transgenerational inheritance and how this affects our kidsHow sunlight affects biological age (and it might not be what you think)Spending time in green space and in nature has a positive effect on biological age and even IQBeing lonely is worse than smoking according to research from HarvardHow relationships and community improve biological ageResources We MentionTruDiagnostic (this link and code wellnessmama gives a discount)Hand Grip Strength Tester

Free newsletter and more: https://newsletter.sankalpgarud.org/52waysguide In this episode of the Understanding Emotions, we explore the crucial pillars of health—sleep, exercise, and nutrition—while diving into the ethical and scientific dimensions of biohacking and longevity. Dr Sanchit Turuga is a medical doctor at the UK's National Health Service and a DPhil (PhD) student in medicine at the University of Oxford. 00:00 Introduction and Setting the Stage 01:25 Foundations of Good Health 03:34 Challenges in Maintaining Health 06:10 The Importance of Sleep 18:53 Exercise: The Second Pillar of Health 32:59 The Impact of Diet on Health 33:39 Debating the Benefits of Vegetarianism 35:05 The Need for More Research 35:57 Practical Challenges of Changing Diets 37:10 Concluding Thoughts on Nutrition 38:34 The Role of Supplements in Health 45:06 The Common Cold and Immunity 51:18 The Debate on Health Tracking and Measurement 01:00:33 The Concept of Longevity Clinics 01:08:05 The Parabiosis Experiment and Blood Transfusions 01:10:28 Biohacking and Longevity Optimization 01:12:21 Caloric Restriction and Exercise for Longevity 01:15:31 The Debate on Aging as a Disease 01:18:15 Personalized Medicine and Supplementation 01:29:28 Gut Microbiome: The New Frontier 01:38:11 Personalized Medicine and Alternative Therapies 01:43:13 Conclusion and Final Thoughts

Join Dr. Josh Axe as he interviews Dr. Paul Saladino, a double board-certified MD and founder of Heart & Soil, who challenges conventional wisdom about diet and chronic illness. In this eye-opening episode, these two experts dive deep into controversial topics that could revolutionize your approach to health. They discuss:  How modern medicine often fails to address the root causes of chronic diseases The surprising environmental impact of veganism vs. carnivore diets Do carnivores eat fruit and vegetables? How to develop a growth mindset and challenge your own beliefs about nutrition Recommendations for reversing autoimmune disease Tune in to gain invaluable insights that could transform your understanding of optimal health. Whether you're a nutrition enthusiast or simply looking to improve your well-being, this episode will equip you with cutting-edge knowledge to make informed decisions about your diet and lifestyle. Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook Tik-Tok Follow Dr. Paul Saladino Instagram Twitter YouTube Tik-Tok ------  0:00 Dr. Paul Saladino Background 9:01 Are vegetables REALLY good for you 16:45 Yin Vs. Yang Diet 24:28 Incorporating Organ Meats in Diet 30:32 Supplements & Vitamins 35:50 Environmental Impacts of Vegan Vs. Carnivore Diet 46:11 Should We Be Eating Fruit? 58:35  Why Most Studies Are False 1:02:54 Caloric Restriction & Fasting 1:10:56  Is Cold Plunging Good For You? 1:14:20 How to Deal With Criticism ------  Links:  Check out the Paul Saladino MD Podcast → https://www.paulsaladinomd.co/resources/podcasts  Purchase Dr. Paul Saladino's book, The Carnivore Code Book → https://www.paulsaladinomd.co/resource/the-carnivore-code  Check out Dr. Paul Saladino's grass-fed beef and organ meat sticks → https://lineageprovisions.com/

Amping AMP-activated protein kinase is one of the anti-aging pathways I cover in my longevity book, How Not to Age.

This week's episode of The Flex Diet Podcast is a special co-broadcast with Dr. Lonnie Lowery and Iron Radio. We come to you live from the annual International Society of Sports Nutrition conference. From the surprising revelation that creatine is illegal for individuals under 18 in New York, shared by Guillermo Escalante, to the debunking of common misconceptions about creatine, this episode is packed with the latest information on dietary science. We discuss the potential benefits of creatine for kids and pregnant women and emphasize the importance of accurate safety data and validating study materials. We also shed light on the prevalent issue of low energy availability among athletes, exploring the balance between dietary intake and metabolic rate. Tune in for this and much more!Sponsors:Tecton Life Ketone drink! https://tectonlife.com/ DRMIKE to save 20%Episode Chapters:(0:00:00) - Sports Nutrition Conference Highlights and Insights(0:07:28) - Effects of GLP-1 Agonists on Appetite(0:13:55) - Nootropics and Anabolism in Nutrition(0:20:11) - Sleep, Diet, & Muscle Anabolism Effects(0:30:14) - Sleep Science Advancements and Data Analysis"(0:41:43) - Creatine Research Findings and Applications(0:46:32) - Creatine Loading and Probiotic Research(1:00:19) - Enhanced Physiques and Deuterated Caffeine(1:06:20) - Elite Masters Athletes and Research Findings(1:11:19) - Nutrition Challenges for Older AthletesFlex Diet and Iron Radio Podcast Episodes You May Enjoy:Flex Diet Podcast Episode 239: Exploring the Science Behind Dieting Strategies with Dr. Bill CampbellIron Radio: Creatine and Sleep, Botanicals, Developing GritIron Radio Episodes:Youtube: https://www.youtube.com/@Lonman07Get In Touch:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

In this episode, CJ delves into the science and practical aspects of caloric restriction, an effective approach to extending lifespan and improving health. Caloric restriction involves reducing calorie intake without causing malnutrition, which has been shown to reduce age-related diseases and improve metabolic health. Key Points Discussed:Introduction to Caloric RestrictionExplanation of caloric restriction and its benefits.Overview of scientific research supporting its efficacy in extending lifespan and enhancing health.Science Behind Caloric RestrictionReduces oxidative stress by lowering the production of free radicals.Enhances cellular repair mechanisms through processes like autophagy.Promotes healthier cells and improved overall health and longevity.Practical Tips for Incorporating Caloric RestrictionIntermittent Fasting: Popular method like the 16/8 approach (16 hours fasting, 8 hours eating).Reducing Daily Calorie Intake: Aim for a 10-20% reduction, focusing on nutrient-dense foods.Mindful Eating: Pay attention to hunger and fullness cues, eat slowly, and savor your meals.Meal Planning: Plan meals ahead to ensure a balance of nutrients and avoid impulsive eating.Monitoring Progress: Keep track of calorie intake and overall well-being using food diaries or apps.Benefits of Caloric Restriction Beyond LongevityImproved metabolic health.Reduced risk of age-related diseases.Enhanced overall well-being.ConclusionEncouragement to make thoughtful dietary choices for long-term health.Reminder to consult healthcare providers before making significant dietary changes.Key Takeaways:Caloric restriction can significantly enhance your lifespan and health by reducing oxidative stress and promoting cellular repair.Intermittent fasting and mindful eating are effective strategies for reducing calorie intake.Planning meals and monitoring progress are crucial for maintaining nutritional balance and achieving caloric restriction goals.The approach is not about deprivation but making healthier, more thoughtful dietary choices.5 Things You Can Start Doing Today:Try Intermittent Fasting: Start with the 16/8 method to control your eating window and reduce calorie intake.Reduce Your Caloric Intake: Aim for a moderate reduction of 10-20% in your daily calories.Eat Nutrient-Dense Foods: Focus on fruits, vegetables, lean proteins, and whole grains to get essential nutrients without excess calories.Practice Mindful Eating: Slow down during meals, pay attention to your body's signals, and stop eating when you feel satisfied.Plan Your Meals: Prepare balanced meals in advance to avoid impulsive eating and ensure you meet your nutritional needs.Caloric restriction is a sustainable and scientifically backed approach to improving health and extending lifespan. By incorporating these practices into your daily routine, you can support your body's natural repair processes and achieve a healthier, longer life. Always consult with a healthcare provider before making significant changes to your diet.

Professor Venki Ramakrishnan, a Nobel laureate for his work on unraveling the structure of function of the ribosome, has written a new book WHY WE DIE which is outstanding. Among many posts and recognitions for his extraordinary work in molecular biology, Venki has been President of the Royal Society, knighted in 2012, and was made a Member of the Order of Merit in 2022. He is a group leader at the MRC Laboratory of Molecular Biology research institute in Cambridge, UK.A brief video snippet of our conversation below. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are available on Apple and Spotify.Transcript with links to audio and external linksEric Topol (00:06):Hello, this is Eric Topol with Ground Truths, and I have a really special guest today, Professor Venki Ramakrishnan from Cambridge who heads up the MRC Laboratory of Molecular Biology, and I think as you know a Nobel laureate for his seminal work on ribosomes. So thank you, welcome.Venki Ramakrishnan (00:29):Thank you. I just want to say that I'm not the head of the lab. I'm simply a staff member here.Eric Topol (00:38):Right. No, I don't want to give you more authority than you have, so that was certainly not implied. But today we're here to talk about this amazing book, Why We Die, which is a very provocative title and it mainly gets into the biology of aging, which Venki is especially well suited to be giving us a guided tour and his interpretations and views. And I read this book with fascination, Venki. I have three pages of typed notes from your book.The Compression of MorbidityEric Topol (01:13):And we could talk obviously for hours, but this is fascinating delving into this hot area, as you know, very hot area of aging. So I thought I'd start off more towards the end of the book where you kind of get philosophical into the ethics. And there this famous concept by James Fries of compression of morbidity that's been circulating for well over two decades. That's really the big question about all this aging effort. So maybe you could give us, do you think there is evidence for compression of morbidity so that you can just extend healthy aging and then you just fall off the cliff?Venki Ramakrishnan (02:00):I think that's the goal of most of the sort of what I call the saner end of the aging research community is to improve our health span. That is the number of years we have healthy lives, not so much to extend lifespan, which is how long we live. And the idea is that you take those years that we now spend in poor health or decrepitude and compress them down to just very short time, so you're healthy almost your entire life, and then suddenly go into a rapid decline and die. Now Fries who actually coined that term compression or morbidity compares this to the One-Hoss Shay after poem by Oliver Wendell Holmes from the 19th century, which is about this horse carriage that was designed so perfectly that all its parts wore out equally. And so, a farmer was riding along in this carriage one minute, and the next minute he found himself on the ground surrounded by a heap of dust, which was the entire carriage that had disintegrated.Venki Ramakrishnan (03:09):So the question I would ask is, if you are healthy and everything about you is healthy, why would you suddenly go into decline? And it's a fair question. And every advance we've made that has kept us healthier in one respect or another. For example, tackling diabetes or tackling heart disease has also extended our lifespan. So people are not living a bigger fraction of their lives healthily now, even though we're living longer. So the result is we're spending the same or even more number of years with one or more health problems in our old age. And you can see that in the explosion of nursing homes and care homes in almost all western countries. And as you know, they were big factors in Covid deaths. So I'm not sure it can be accomplished. I think that if we push forward with health, we're also going to extend our lifespan.Venki Ramakrishnan (04:17):Now the argument against that comes from studies of these, so-called super centenarians and semi super centenarians. These are people who live to be over 105 or 110. And Tom Perls who runs the New England study of centenarians has published findings which show that these supercentenarians live extraordinarily healthy lives for most of their life and undergo rapid decline and then die. So that's almost exactly what we would want. So they have somehow accomplished compression of morbidity. Now, I would say there are two problems with that. One is, I don't know about the data sample size. The number of people who live over 110 is very, very small. The other is they may be benefiting from their own unique genetics. So they may have a particular combination of genetics against a broad genetic background that's unique to each person. So I'm not sure it's a generally translatable thing, and it also may have to do with their particular life history and lifestyle. So I don't know how much of what we learned from these centenarians is going to be applicable to the population as a whole. And otherwise, I don't even know how this would be accomplished. Although some people feel there's a natural limit to our biology, which restricts our lifespan to about 115 or 120 years. Nobody has lived more than 122. And so, as we improve our health, we may come up against that natural limit. And so, you might get a compression of morbidity. I'm skeptical. I think it's an unsolved problem.Eric Topol (06:14):I think I'm with you about this, but there's a lot of conflation of the two concepts. One is to suppress age related diseases, and the other is to actually somehow modulate control the biologic aging process. And we lump it all together as you're getting at, which is one of the things I loved about your book is you really give a balanced view. You present the contrarians and the different perspectives, the perspective about people having age limits potentially much greater than 120, even though as you say, we haven't seen anyone live past 122 since 1997, so it's quite a long time. So this, I think, conflation of what we do today as far as things that will reduce heart disease or diabetes, that's age related diseases, that's very different than controlling the biologic aging process. Now getting into that, one of the things that's particularly alluring right now, my friend here in San Diego, Juan Carlos Belmonte, who went over from Salk, which surprised me to the Altos Labs, as you pointed on in the book.Venki Ramakrishnan (07:38):I'm not surprised. I mean, you have a huge salary and all the resources you want to carry out the same kind of research. I wouldn't blame any of these guys.Rejuvenating Animals With Yamanaka FactorsEric Topol (07:50):No, I understand. I understand. It's kind of like the LIV Golf tournament versus the PGA. It's pretty wild. At any rate, he's a good friend of mine, and I visited with him recently, and as you mentioned, he has over a hundred people working on this partial epigenetic reprogramming. And just so reviewing this for the uninitiated is giving the four Yamanaka transcription factors here to the whole animal or the mouse and rejuvenating old mice, essentially at least those with progeria. And then others have, as you point out in the book, done this with just old mice. So one of the things that strikes me about this, and in talking with him recently is it's going to be pretty hard to give these Yamanaka factors to a person, an intravenous infusion. So what are your thoughts about this rejuvenation of a whole person? What do you think?Venki Ramakrishnan (08:52):If I hadn't seen some of these papers would've been even more skeptical. But the data from, well, Belmonte's work was done initially on progeria mice. These are mice that age prematurely. And then people thought, well, they may not represent natural aging, and what you're doing is simply helping with some abnormal form of aging. But he and other groups have now done it with normal mice and observed similar effects. Now, I would say reprogramming is one way. It's a very exciting and powerful way to almost try to reverse aging because you're trying to take cells back developmentally. You're taking possibly fully differentiated cells back to stem cells and then helping regenerate tissue, which one of the problems as we age is we start losing stem cells. So we have stem cell depletion, so we can no longer replace our tissues as we do when we're younger. And I think anyone who knows who's had a scrape or been hurt in a fall or something knows this because if I fall and scrape my elbow and get a big bruise and my grandson falls, we repair our tissues at very, very different rates. It takes me days or weeks to recover, and my grandson's fine in two or three days. You can hardly see he had a scrape at all. So I think that's the thing that these guys want to do.Venki Ramakrishnan (10:48):And the problem is Yamanaka factors are cancer. Two of them are oncogenic factors, right? If you give Yamanaka factors to cells, you can take them all the way back to what are called pluripotent cells, which are the cells that are capable of forming any tissue in the body. So for example, a fertilized egg or an early embryo cells from the early embryo are pluripotent. They could form anything in the body. Now, if you do that to cells with Yamanaka factors, they often form teratomas, which are these unusual forms of cancer tumors. And so, I think there's a real risk. And so, what these guys say is, well, we'll give these factors transiently, so we'll only take the cells back a little ways and not all the way back to pluripotency. And that way if you start with skin cells, you'll get the progenitor stem cells for skin cells. And the problem with that is when you do it with a population, you're getting a distribution. Some of them will go back just a little, some of them may go back much more. And I don't know how to control all this. So I think it's very exciting research. And of course, if I were one of these guys, I would certainly want to carry on doing that research. But I don't think it's anywhere near ready for primetime in terms of giving it to human beings as a sort of anti-aging therapeutic.Aging and Cancer Shared HallmarksEric Topol (12:31):Yeah. Well, I couldn't agree more on that because this is a company that's raised billions of dollars to go into clinical trials. And the question that comes up here, which is a theme in the book and a theme with the aging process to try to artificially, if you will affect it, is this risk of cancer. And as we know, the hallmarks of aging overlap considerably with the hallmarks of cancer. And this is just one example, as you mentioned, where these transcription factors could result in generating cancer. But as you also point out in the book at many places, methylation changes, DNA, repair, and telomeres.Venki Ramakrishnan (13:21):And telomeres.Venki Ramakrishnan (13:24):All of those are related to cancer as well. And this was first pointed out to me by Titia de Lange, who's a world expert on telomeres at Rockefeller, and she was pointing out to me the intimate connection between cancer and aging and many mechanisms that have evolved to prevent cancer early in life tend to cause aging later in life, including a lot of DNA damage response, which sends cells into senescence and therefore causes aging. Buildup of senescence cells is a problem later in life with aging, but it has a role which is to prevent cancer early in life. And so, I think it's going to be the same problem with stem cell therapy. I think very targeted stem cell therapy, which is involved in replacing certain tissues, the kind of regenerative medicine that stem cells have been trying to address for a very long time, and only now we're beginning to see some of the successes of that. So it's been very slow, even when the goal and target is very specific and well-defined, and there you are using that stem cell to treat a pretty bad disease or some really serious problem. I think with aging, the idea that somebody might take this so they can live an extra 10 years, it's a much higher bar in terms of safety and long-term safety and efficacy. So I don't think that this is going to happen anytime soon, but it's not to say it'll never happen. There is some serious biology underlying it.Eric Topol (15:13):Right. Well, you just touched on this, but of course the other, there's several big areas that are being explored, and one of them is trying to deal with these senescent cells and trying to get rid of them from the body because they can secrete evil humors, if you will. And the problem with that, it seems that these senescent cells are sort of protective. They stop dividing, they're not going to become cancerous, although perhaps they could contribute to that in some way. So like you say, with telomeres and so many things that are trying to be manipulated here, there's this downside risk and it seems like this is what we're going to have to confront this. We have seen Venki with the CAR-T, the T-cell engineering, there's this small risk of engendering cancer while you're trying to deal with the immune system.SenolyticsVenki Ramakrishnan (16:07):Yeah, I think with senescent cells, the early in life senescent cells have an important role in biology. They're essentially signaling to the immune system that there's a site that's subject to viral infection or wounds or things like that. So it's a signal to send other kinds of cells there to come and repair the damage. Now, of course, that evolved to help us early in life. And also many senescent cells were a response to DNA damage. And that's again, a way for the body that if your DNA is damaged, you don't want that cell to be able to divide indefinitely because it could become cancerous. And so, you send it into senescence and get it out of harm's way. So early life, we were able to get rid of these senescent cells, we were able to come to the site and then clean up the damage and eventually destroy the senescent cells themselves.Venki Ramakrishnan (17:08):But as we get older, the response mechanisms also deteriorate with age. Our immune system deteriorates with age, all the natural signaling mechanisms deteriorate with age. And so, we get this buildup of senescent cells. And there people have asked, well, these senescent cells don't just sit there, they secrete inflammatory compounds, which originally was a feature, not a bug, but then it becomes a problem later in life. And so, people have found that if you target senescent cells in older animals, those animals improve their symptoms of aging improved dramatically or significantly anyway. And so, this has led to this whole field called senolytics, which is being able to specifically target senescent cells. Now there the problem is how would you design compounds that are highly specific for senescent cells and don't damage your other cells and don't have other long-term side effects? So again, I think it's a promising area, but a lot of work needs to be done to establish long-term safety and efficacy.Eric Topol (18:23):Right. No, in fact, just today in Nature, there's a feature on killing the zombie cells, and it discusses just what you're pointing out, which is it's not so easy to tag these specifically and target them, even though as you know, there's some early trials and things like diabetic macular edema. And we'll see how that plays out. Now, one of the things that comes up is the young blood story. So in the young blood, whether it's this parabiosis or however you want to get at it, and I guess it even applies to the young microbiome of a gut, but there's this consistent report that there's something special going on there. And of course the reciprocal relationship of giving the old blood to the young mice, whatever, but no one can find the factor, whether it's platelet factor 4, GDF11, or what are your thoughts about this young blood story?Venki Ramakrishnan (19:25):I think there's no question that the experiments work because they were reproduced and they were reproduced over quite a long period, and which is that when you connect an old mouse or rat with a young equivalent, then the old mouse or old rat benefits from the young blood from the younger animal. And conversely, the younger animal suffers from the blood from the older animal. And then people were wondering whether this is simply that the young animal has better detoxification and things like that, or whether it's actually the blood. And they gave it just as transfusion without connecting the animals and showed that it really was the blood. And so, this of course then leads to the question, well, what is it about young blood that's beneficial and what is it about old blood that is bad? But the problem is blood has hundreds of factors. And so, they have to look at which factors are significantly different, and they might be in such small quantities that you might not be able to detect those differences very easily.Venki Ramakrishnan (20:40):And then once you've detected differences, then you have to establish their mechanism of action. And first of all, you have to establish that the factor really is beneficial. Then you have to figure out how it works and what its potential side effects could be. And so again, this is a promising area where there's a lot of research, but it has not prevented people from jumping the gun. So in the United States, and I should say a lot of them in your state, California somehow seems to attract all these immortality types. Well, anyway, a lot of companies set up to take blood from young donors, extract the plasma and then give it to rich old recipients for a fee for a healthy fee. And I think the FDA actually shut down one of them on the grounds that they were not following approved procedure. And then they tried to start up under a different name. And then eventually, I don't know what happened, but at one point the CEO said something I thought was very amusing. He said, well, the problem with clinical trials is that they take too long. I'm afraid that's characteristic of some portion of this sort of anti-aging therapeutics community. There's a very mainstream rigorous side to it, but there's also at the other end of the spectrum, kind of the wild west where people just sell whatever they can. And I think this exploits people's fear of getting old and being disabled or things like that and then dying. And I think the fear seems to be stronger in California where people like their lives and don't want to age.Eric Topol (22:49):You may be right about that. I like your term in the book immortality merchants, and of course we'll get into a bit, I hope the chapter on the crackpots and prophets that you called it was great. But that quote, by the way, which was precious from, I think it was Ambrosia, the name of the company and the CEO, but there's another quote in the book I want to ask you about. Most scientists working on aging agree that dietary restriction can extend both healthy life and overall life in mice and also lead to reductions in cancer, diabetes, and overall mortality in humans. Is that true? Most scientists think that you can really change these age-related diseases.Caloric Restriction and Related PathwaysVenki Ramakrishnan (23:38):I think if you had to pick one area in which there's broad agreement, it is caloric restriction. But I wouldn't say the consensus is complete. And the reason I say that is that most of the comparisons are between animals that can eat as much as they want, called ad libitum diet and mice that are calorically restricted or same with other animals even yeast. You either compared with an extremely rich medium or in a calorically restricted medium. And this is not a great comparison. And people, there's one discrepancy, and that was in monkeys where an NIH study didn't find huge differences, whereas a Wisconsin study found rather dramatic differences between the control group and the calorically restricted group. And so, what was the difference? Well, the difference was that the NIH study, the controlled group didn't have a calorically restricted diet, but still had a pretty reasonable diet.Venki Ramakrishnan (24:50):It wasn't given a unhealthy rich diet of all you can eat. And then they tried to somehow reconcile their findings in a later study. But it leads to the question of whether what you can conclude is that a rich all you can eat diet, in other words, gorging on an all you can eat buffet is definitely bad for you. So that's why you could draw that conclusion rather than saying it's actually the caloric restriction. So I think people need to do a little more careful study. There was also a study on mice which took different strains of mice and showed that in some strains, caloric restriction actually shortened lifespan didn't increase lifespan. Now, much of the aging community says, ah, that's just one study. But nobody's actually shown whether there was anything wrong with that study or even tried to reproduce it. So I think that study still stands.Venki Ramakrishnan (25:51):So I think it's not completely clear, but the fact is that there's some calorie dependence that's widely been observed across species. So between the control group and the experimental group, whatever you may, however, you may define it as there's been some effective calories intake. And the other interesting thing is that one of the pathways affected by caloric restriction is the so-called TOR pathway and one of the inhibitors of the TOR pathways is rapamycin. And rapamycin in studies has also shown some of these beneficial effects against the symptoms of aging and in lifespan. Although rapamycin has the same issue as with many other remedies, it's an immunosuppressive drug and that means it makes you more prone to infection and wound healing and many other things. I believe one of them was there's a question of whether it affects your libido, but nevertheless, that has not prevented rapamycin clinics from opening up, did I say in California? So I do think that there's often serious science, which leads to sort of promising avenues. But then there are of course people who jump the gun and want to go ahead anyway because they figure by the time trials are done, they'll be dead and they'd rather try act now.Eric Topol (27:36):Right. And you make a good, I mean the rapamycin and mTOR pathway, you really developed that quite a bit in the book. It's really quite complex. I mean, this is a pleotropic intervention, whether it's a rapalogs or rapamycin, it's just not so simple at all.Venki Ramakrishnan (27:53):Right. It's not at all simple because the TOR pathway has so many consequences. It affects so many different processes in the cell from including my own field of protein synthesis. It's one of the things it does is shut down global protein synthesis, and that's one of the effects of inhibiting TOR. So, and it turns up autophagy, which is this recycling of defective proteins and entirely defective entire organelles. So I think the TOR pathway is like a hub in a very large network. And so, when you start playing with that, you're going to have multiple consequences.Eric Topol (28:37):Yeah, no. And another thing that you develop so well is about this garbage disposal waste disposal system, which is remarkably elaborate in the cell, whether it's the proteasome for the proteins and the autophagosome for the autophagy with the lysosomes and the mitochondria mitophagy. Do you want to comment about that? Because this is something I think a lot of people don't appreciate, that waste management in the cell is just, it's a big deal.Venki Ramakrishnan (29:10):So we always think of producing things in the cell as being important, making proteins and so on. But the fact is destroying proteins is equally important because sometimes you need proteins for a short time, then they've done their job and you need to get rid of them, or proteins become dysfunctional, they stop working, or even worse, they start clumping together and causing diseases for example you could think of Alzheimer's as a disease, which involves protein tangles. Of course, the relationship between the tangles and the disease is still being worked out, but it's a characteristic of Alzheimer's that you have these protein tangles and the cell has evolved very elaborate mechanisms to constantly turn over defective proteins. Well, for example, it senses when proteins are unfolded and essentially the chain has unraveled and is now sticking to all sorts of things and causing problems. So I think in all of these cases, the cells evolved very elaborate mechanisms to recycle defective products, to have proper turnover of proteins. And in fact, recycling of entire organelles like mitochondria, when they become defective, the whole mitochondria can be recycled. So these systems also break down with aging. And so, as we age, we have more of a tendency to accumulate unfolded proteins or to accumulate defective mitochondria. And it's one of the more serious problems with aging.Eric Topol (30:59):Yeah, there's quite a few of them. Unfortunately, quite a few problems. Each of them are being addressed. So there's many different shots on goal here. And as you also aptly point out, they're interconnected. So many of these things are not just standalone strategies. I do want to get your sense about another popular thing, especially here out in California, are the clocks, epigenetic clocks in particular. And these people are paying a few hundred dollars and getting their biologic age, which what is that? And they're also thinking that I can change my future by getting clocks. Some of these companies offer every few months to get a new clock. This is actually remarkable, and I wonder what your thoughts are about it.Venki Ramakrishnan (31:48):Well, again, this is an example of some serious biology and then people jumping the gun to use it. So the serious biology comes from the fact that we age at different rates individuals. So anyone who's been to a high school reunion knows this. You'll have classmates who are unrecognizable because they've aged so much and others who've hardly changed since you knew them in high school. So of course at my age, that's getting rarer and rarer. But anyway, but you know what I mean. So the thing is that, is there a way that we can ask on an individual level how much has that individual aged? And there are markers that people have identified, some of them are markers on our DNA, which you mentioned in California. Horvath is a very famous scientist who has a clock named after him actually, which has to do with methylation of our DNA and the patterns of methylation affect the pattern of gene expression.Venki Ramakrishnan (33:01):And that pattern changes as we age. And they've shown that those patterns are a better predictor of many of the factors of aging. For example, mortality or symptoms of aging. They're a better predictor of that than chronological age. And then of course there are blood markers, for example, levels of various blood enzymes or blood factors, and there are dozens of these factors. So there are many different tests of many different kinds of markers which look at aging. Now the problem is these all work on a population level and they also work on an individual level for time comparison. That is to say, if you want to ask is some intervention working? You could ask, how fast are these markers changing in this person without the intervention and how fast are they changing with the intervention? So for these kind of carefully controlled experiments, they work, but another case is, for example, glycosylation of proteins, especially proteins of your immune system.Venki Ramakrishnan (34:15):It turns out that adding sugar groups to your immune system changes with age and causes an immune system to misfire. And that's a symptom of aging. It's called inflammaging. So people have used different markers. Now the problem is these markers are not always consistent with each other because you may be perfectly fine in many respects, but by some particular marker you may be considered old just because they're comparing you to a population average. But how would you say one person said, look, we all lose height as we age, but that doesn't mean if you take a short person, you can consider them old. So it's a difference between an individual versus a population, and it's a difference between what happens to an individual by following that individual over time versus just taking an individual and comparing it to some population average. So that's one problem.Organ ClocksVenki Ramakrishnan (35:28):The other problem is that our aging is not homogeneous. So there's a recent paper from I believe Tony Wyss-Coray group, which talks about the age of different organs in the same person. And it turns out that our organs, and this is not just one paper, there are other papers as well. Our organs don't necessarily age at the same rate. So giving a single person, giving a person a single number saying, this is your biological age, it's not clear what that means. And I would say, alright, even if you do it, what are you going to do about it? What can you do about it knowing your biological, the so-called number of a biological age. So I'm not a big fan. I'm a big fan of using these markers as a tool in research to understand what interventions work because otherwise it would take too long. You'd have to wait 20 years to see some large scale symptoms. And certainly, if you want to look at mortality, you'd have to wait possibly even longer. But if you were to be able to follow track these interventions and see that these markers slowed down with intervention, then you could say, well, your interventions having an effect on something related to aging. So I would say these are very useful research tools, but they're not meant to be used at $500 a pop in your age.Venki Ramakrishnan (37:02):But of course that hasn't stopped lots of companies from doing it.Eric Topol (37:07):No, it's just amazing actually. And by the way, we interviewed Tony Wyss-Coray about the organ clock, the paper. I thought it really was quite a great contribution, again, on a research level.Venki Ramakrishnan (37:19):He's a very serious scientist. He actually spoke here at the LMB as well. He gave a very nice talk here.Is Aging A Disease?Eric Topol (37:26):He's the real deal. And I think that's going to help us to have that organ specific type of tracking is another edge here to understand the effects. Well, before we wrap up, I want to ask you a question that you asked in the book. Is aging a disease?Venki Ramakrishnan (37:49):That's again, a controversial subject. So the WHO, and I believe the FDA decided that aging was not a disease on the grounds that it's inevitable and ubiquitous. It happens to everybody and it's inevitable. So how could something that happens to everybody and inevitable be considered a disease? A disease is an abnormal situation. This is a normal situation, but the anti-aging researchers and especially the anti-aging therapeutics people don't like that because if it's not a disease, how can they run a clinical trial? So they want aging to be considered a disease. And their argument is that if you look at almost every condition of old age, every disease of old age like cancer, diabetes, heart disease, dementia, the biggest risk factor in all of these diseases is age. That's the strongest risk factor. And so, they say, well, actually, you could think of these diseases as secondary diseases, the primary disease being age, and then that results in these other diseases.Venki Ramakrishnan (39:07):I am a little skeptical of that idea. I tend to agree with the WHO and the FDA, but I can see both sides of the argument. And as you know, I've laid them both out. My view is that it should be possible to do trials that help with aging regardless of whether you consider aging a disease or not. But that will require the community to agree on what set of markers to use to characterize success. And that's people, for example, Tony Wyss-Coray has his proteome, blood proteome markers, Horvath has his DNA methylation clock. There are a whole bunch of these. And then there are people with glycation or glycosylation of various proteins as markers. These people need to all come together. Maybe we need to organize a nice conference for them in some place like Southern California or Hawaii or somewhere, put them together in a locked room for a week so that they can thrash out a common set of markers and at least agree on what experiments they need to do to even come to that agreement and then use that to evaluate anti-aging therapies. I think that would be a way forward.Eric Topol (40:35):Yeah, I think you're bringing up a really valuable point because at the moment, they're kind of competing with one another, whether it's the glycosylated proteins or the transcriptomics or the epigenetics. And we don't know whether these are additive or what they're really measuring.Venki Ramakrishnan (40:53):Some of them may be highly correlated, and that's okay, but I think they need to know that. And they also need to come up with some criteria of how do we define age in an individual. It's not one number, just like we have many things that characterize our health. Cholesterol is one, blood pressures another, various other lipids. They're all blood enzymes, liver enzymes. All these things are factors in defining our so-called biological health. So I don't think there's some single number that's going to say this is your age. Just like there isn't one single thing that says you're healthy, you're not healthy.DNA RepairEric Topol (41:38):Right, that's well put. Last topic on aging is on about DNA repair, which is an area that you know very well. And one of the quotes in your book, I think is important for people to take in. “Nevertheless, they will make an error once every million or so letters in a genome with a few billion letters. That means several thousand mistakes occur each time a cell divides. So the DNA repair enzyme, as you point out the sentinels of our genome, the better we repair, the better we age.” Can we fix the DNA repair problem?Venki Ramakrishnan (42:20):I think maybe, again, I'm not sure what the consequences would be and how much it would take. There's one curious fact, and that is that there was a paradox called Peto's paradox after the scientist who discovered it, which is why don't big animals get cancer much more frequently than say a mouse? In fact, a mouse gets cancer far more readily than an elephant does, and in reality, the elephant should actually get cancer more because it has many orders of magnitude more cells, and all it takes is for one cell to become cancerous for the animal to get cancer and die. So the chances that one cell would become cancer would be larger if there are many, many more cells. And it turns out that elephants have many copies of DNA repair proteins or DNA damage response proteins, not so much DNA repair, but the response to DNA damage and in particular, a protein called p53. And so, this leads to the question that if you had very good DNA repair or very good DNA damage response, would you then live longer or solve this problem? I'm not entirely sure because it may have other consequences because for example, you don't want to send cells into senescence too easily. So I think these things are all carefully balanced, evolutionarily, depending on what's optimized to optimize fitness for each species.Venki Ramakrishnan (44:13):For a mouse, the equation's different than for a large animal because a mouse can get eaten by predators and so on. So there, it doesn't pay for evolution to spend too much select for too much spending of resources in maintenance and repair, for larger animals the equation is different. So I just don't know enough about what the consequences would be.Eric Topol (44:40):No, it's really interesting to speculate because as you point out in the book, the elephant has 20 copies of p53, and we have two as humans. And the question is that protection from cancer is very intriguing, especially with the concerns that we've been talking about.Venki Ramakrishnan (44:57):And it was also true, I believe they did some analysis of genomics of these whales that live very long, and they found sorts of genes that are probably involved in DNA repair or DNA damage response.Eric Topol (45:14):Well, this is a masterful book. Congratulations, Venki. I thoroughly enjoyed it. It's very stimulating. I know a lot of the people that will listen or read the transcript will be grabbed by it.Crackpots and ProphetsVenki Ramakrishnan (45:28):I think what I've tried to do is give the general reader a real understanding of the biology of aging so that even a complete non-scientist can get an understanding of the processes, which in turn empowers them to take action to do the sort of things that will actually really help. And also it'll guard them against excessive hype, of which there's a lot in this business. And so, I think that was the goal, and to try and present a balanced view of the field. I'm merely trying to be a realist. I'm not being a pessimist about it, but I also think this excessively optimistic hype is actually bad for the field and bad for science and bad for the public as well.Eric Topol (46:16):Well, and you actually were very kind in the chapter you have on crackpots and prophets. You could have been even tougher on some of these guys. You were very relatively diplomatic and gentle, I thought, I don't know if you were holding back.Venki Ramakrishnan (46:28):I had two lawyers looked at it, so.Eric Topol (46:33):I believe it. And now one thing, apart from what we've been talking about because of your extraordinary contribution on the structural delineation of the ribosome back in the early 2000s and 2009 Nobel Prize. Now, the world of AI now with AlphaFold 3 and all these other large language models, would that have changed your efforts? Would that have accelerated things or is it not really?Venki Ramakrishnan (47:09):Well, it would've helped, but you would still need the experimental data to solve something like the ribosome, a large complex like the ribosome. And the other thing that would really change well has changed our world is the advent of cryo-electron microscopy of which Scripps is one of the leading places for it. And that has really changed it so that now nobody would bother to crystallize a ribosome and try to get an X-ray structure out of it. You would just throw it into an EM grid, collect your data and be off to the races. So new ribosome structures are being solved all the time at a fraction, a tiny fraction of the time it took to solve the first one.Eric Topol (48:02):Wow, that's fascinating. This has been a real joy for Venki to discuss your book and your work, and thanks so much for what you're doing to enlighten us and keep the balance. And it may not be as popular as the immortality merchants, but it's really important stuff.Venki Ramakrishnan (48:19):Yeah, no, I hope actually, I found that many of the public want to read about the biology of aging. They're curious. Humans have been curious ever since we knew about mortality, about why some species live so short lives and other species live such a long time and why we actually have to age and die. So there's natural curiosity and then it also empowers the public once they understand the basis of aging, to take action, to live healthy lives and do that. It's an empowering book rather than a recipe book.Venki Ramakrishnan (49:01):I think a lot of the public actually does appreciate that. And of course, scientists will like the sort of more balanced and tone.Eric Topol (49:13):Well, you do it so well. All throughout you have metaphors to help people really understand and the concepts, and I really applaud you for doing this. In fact, a couple of people who we both know, Max and John Brockman, apparently were influential for you to get to do it. So I think it's great that you took it on and all the power to you. So thank you, and I hope that we'll get a chance to visit further as we go forward.******************Headshot photo credits by Kate Joyce and Santa Fe InstituteThe Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informativeVoluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff tor audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in.A Poll on Anti-Aging Get full access to Ground Truths at erictopol.substack.com/subscribe

In the current episode of The VitaDAO Aging Science Podcast, we dive into the intricate world of rapamycin, caloric restriction, and inflammaging with the distinguished Dr. Arlan Richardson. Dr. Richardson, a pioneer in aging research with a career spanning over five decades, shares his extensive knowledge and groundbreaking insights. We discuss his pioneering work on rapamycin, the complexities of caloric restriction, and the role of chronic inflammation in aging. This episode also touches on the significance of necroptosis, the intriguing connections between senescence and inflammation, and the future of aging interventions. Join us as we explore these vital topics and their implications for human longevity, shedding light on the critical role of preclinical studies in advancing our understanding of aging.

Join us as we welcome Dr. Stephen Noseworthy to discuss the principles of functional medicine. Dr. Noseworthy shares his personal journey from marketing professional to a pioneer in alternative health, emphasizing the importance of understanding individual biological differences and metabolic adaptability. He provides practical advice on tailoring health strategies, covering topics such as fasting, exercise, and caloric management based on his extensive clinical experience.Explore the shift from traditional to modern, technology-driven medical consultations, highlighting the balance between family life and a successful virtual clinic. We delve into the enhancements in patient engagement and care efficacy brought by innovations like social media and electronic medical records, drawing on the economic challenges and adaptability required in the early days of establishing a functional medicine practice.Concluding our episode, Dr. Noseworthy addresses complex health issues like autoimmunity and neurological conditions, debunking common health myths and urging personalized treatment plans. He discusses the importance of dietary customization, particularly the balance of caloric intake for optimal brain function, and challenges popular misconceptions with a clinical approach that respects individual health profiles. Chapters:(00:00) Functional Medicine with Dr. Noseworthy(11:10) Evolution of a Virtual Practice(15:54) Transitioning to Virtual Practice and Technology(25:47) Exploring Autoimmunity and Functional Medicine(40:00) Impact of Caloric Restriction on Brain(46:30) Carbohydrate Sweet Spot and Energy Sufficiency(55:41) Clinical Approach to Functional Medicine Links:Drnoseworthy.comInflammation Nation Podcast (https://podcasts.apple.com/us/podcast/inflammation-nation-science-informed-wellness/id1587867271)Func Med Nation Podcast (https://podcasts.apple.com/us/podcast/func-med-nation-a-podcast-for-functional/id1669044741) Join Over 18,000 Leading Medical Professionals and Become a Vibrant Wellness Provider Today! (https://portal.vibrant-wellness.com/#/sign-up)

// GUEST // Podcast: https://podcasts.apple.com/us/podcast/paul-saladino-md-podcast/id1461771083 The Carnivore Code: https://www.amazon.com/dp/B089KB41VCThe Carnivore Code Cookbook: https://www.amazon.com/dp/B08NWTKQLF Website: https://www.paulsaladinomd.co/ YouTube: https://www.youtube.com/@Paulsaladinomd Twitter: https://twitter.com/paulsaladinomd Instagram: https://www.instagram.com/paulsaladinomd/ TikTok: https://www.tiktok.com/@paulsaladinomd2// SPONSORS // In Wolf's Clothing: https://wolfnyc.com/Heart and Soil Supplements (use discount code BREEDLOVE): https://heartandsoil.co/Anthony DiClementi's Biohacking Secrets (Text BREEDLOVE to 847-943-7221) Swan Bitcoin: https://www.swanbitcoin.com/breedlove22/// EVENTS I WILL BE ATTENDING // Bitcoin 2024: the World's Largest Bitcoin Conference (use discount code BREEDLOVE): https://b.tc/conferenceLibertarian National Convention: https://lnc2024.com/ Pacific Bitcoin 2024: https://www.pacificbitcoin.com/// PRODUCTS I ENDORSE // Protect your mobile phone from SIM swap attacks: https://www.efani.com/breedlove// OUTLINE // 0:00 - WiM Show Intro 1:57 - Helping Lightning Startups with In Wolf's Clothing 2:45 - Introducing Paul Saladino 8:49 - What is an Animal-Based Diet? 17:01 - Paul's Daily Diet 26:38 - Restricting Carbohydrates 32:26 - Heart and Soil Supplements 33:26 - Anthony DiClementi's Biohacking Secrets 34:55 - Animal-Based Travel Tips 42:26 - Dangers of Seed Oils 53:48 - Calories In vs Calories Out 01:04:15 - Diet vs Exercise 01:06:54 - Swan Bitcoin: Set up instant and Recurring Bitcoin Buys 01:08:27 - Bitcoin 2024: The Largest Bitcoin and Fintech Conference in the World 01:09:33 - Bryan Johnson's Blueprint 01:20:58 - Risks of Fasting 01:32:37 - Caloric Restriction 01:37:11 - Quality vs Quantity 01:40:17 - Where to find Paul Saladino// PODCAST // Podcast Website: https://whatismoneypodcast.com/Apple Podcast: https://podcasts.apple.com/us/podcast/the-what-is-money-show/id1541404400Spotify: https://open.spotify.com/show/25LPvm8EewBGyfQQ1abIsE?RSS Feed: https://feeds.simplecast.com/MLdpYXYI// SUPPORT THIS CHANNEL // Bitcoin: 3D1gfxKZKMtfWaD1bkwiR6JsDzu6e9bZQ7 Sats via Strike: https://strike.me/breedlove22 Sats via Tippin.me: https://tippin.me/@Breedlove22Dollars via Paypal: https://www.paypal.com/paypalme/RBreedloveDollars via Venmo: https://account.venmo.com/u/Robert-Breedlove-2The "What is Money?" Show Patreon Page: https://www.patreon.com/user?u=32843101 // WRITTEN WORK // Medium: https://breedlove22.medium.com/Substack: https://breedlove22.substack.com/ // SOCIAL // Breedlove Twitter: https://twitter.com/Breedlove22WiM? Twitter: https://twitter.com/WhatisMoneyShowLinkedin: https://www.linkedin.com/in/breedlove22/Instagram: https://www.instagram.com/breedlove_22/TikTok: https://www.tiktok.com/@breedlove22All My Current Work: https://vida.page/breedlove22

This episode is brought to you by Cozy Earth, Lifeforce, and Lumebox.Despite significant strides in cancer research over the past two decades, there remains a vast realm of uncertainty surrounding the impact of various cancers on individuals. Amidst the proliferation of cancer discourse on social media, distinguishing evidence-based information from conjecture can prove challenging. Today's guest is here to untangle all the complexities. Today, on The Dhru Purohit Show, Dhru sits down with Dr. Joseph Zundell to discuss the research behind cancer prevention. Dr. Zundell shares the lifestyle factors that influence the development of cancer and the cutting-edge technologies for early cancer detection. Dr. Joe Zundell received his Ph.D. in cancer biology through the University of the Sciences and The Wistar Institute in Philadelphia, PA. He has over ten years of cancer research experience as a cancer biologist. Much of his published research has focused on finding new therapies for the treatment of many different cancer types based on the epigenetic and metabolic characteristics of cancers. In this episode, Dhru and Dr. Zundell dive into (audio version / Apple Subscriber version):Technology for early detection of cancer (4:55 / 4:55)Obesity and visceral fats link to cancer (22:56 /19:30)Exercising to build muscle and for longevity (28:57 / 25:06)Protein intake and the metabolic process (35:00 / 30:23)Fasting mimicking diet before chemotherapy (47:14 / 42:17)Otto Werberg's research (53:17 / 49:39)Cancer as a metabolic disease (58:15 / 53:40)An overview of Dr. Thomas Seyfried's work and Dr. Zundell's viewpoint (1:07:07 / 1:02:08)Dr. Zundell's views on what needs additional research (1:09:43 / 1:05:09)Dr. Zundell's origin story (1:18:54 / 1:13:00)Socioeconomic status and its impact on disease (1:30:37/ 1:26:38)Rapid fire community questions (1:34:02 / 1:28:35)Also mentioned in this episode:Dr. Zundell's research Get $300 off Prenuvo at prenuvo.com/dhru (not an affiliate link)Ezra Test Fasting and Caloric Restriction in Cancer Prevention and TreatmentProfessor Valter Longo's Study Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DHRUP.Right now, you can save $250 on your first diagnostic and get personalized suggestions. Optimize your longevity and track your progress go to mylifeforce.com/dhru! Lumebox is offering my community $260 off their FDA-approved portable Red Light device! That's over 50% off! Go to thelumebox.com/dhru and get your Red Light device. Hosted on Acast. See acast.com/privacy for more information.

Josh Mitteldorf, is a science writer, researcher in biology of aging, and poet, with a rebellious spirit and persistent curiosity. His interests span all the biggest topics in current affairs, as well as eternal questions of the human condition. Who is behind the pandemic and other assaults on humanity? Why do ETs look like us? Can the future reach back in time to cause the past? Are there transformative technologies, available to a select few that have been withheld from the public?Dr Mitteldorf earned a Ph.D. in astrophysics from the University of Pennsylvania. He has written a popular book and an academic book on the biology of aging. His websites include Aging Matters Blog, Experimental Frontiers, the Daily Inspiration, and Unauthorized Science. His forthcoming book includes a sonnet and graphic for each of the 64 hexagrams of the I Ching.Dr Mitteldorf lives in Philadelphia, where he teaches a weekly yoga class and plays in chamber music groups and a community orchestra. His two daughters were adopted from China in the 1980s, breaking diplomatic ground for a wave of Chinese-American adoptions in the following decades.The interview delves into both his biographical and psychological past, unveiling the complex and multifaceted life of Dr. Mitteldorf. He seamlessly blends science, spirituality, and a profound sense of social responsibility in his pursuit to enhance the human experience.The episode concludes with a poem reflecting his belief in the interconnectedness of all beings. Listen for the threads that tie together the spiritual, scientific, and activist pursuits of this extraordinary individual. Photo Credit: Josh MitteldorfTime Stamps(01:40) Intro (04:16) Connecting the Threads of Josh's Work - Buying Freedom(07:31) Graduate Studies Berkeley, Life in Taiwan and Return to the US(13:38) Caloric Restriction and Interest in Evolution Biology(20:28) Predator / Prey Model and Evolutionary Basis for Death(23:35) Thoughts on Anti-Aging Communities and Options(26:42) Transhumanist Movement / Materialist World Views/ Post Materialist Physics / Consciousness (32:49) Spiritual Awakening / from Secular Jew to Quaker to Yoga(37:55) Political Awakening / Work on Election Integrity 2004 / 9-11(44:15) Confidence and Group Dynamics(49:16) Eye Of the Storm / Collective Unconscious(52:02) UAP / UFO Phenomenon / Unauthorized Science (1:01:44) Poem: Intersubjective Bootstrap This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit leafbox.substack.com

How can we make sense of the disparate results from the four primate studies on caloric restriction and lifespan?

Dr. Joel Fuhrman introduces the core principles of the nutritarian diet, emphasizing the significance of balancing caloric intake with nutrient richness. He stresses that as we distance ourselves from addictive and harmful foods, our taste preferences change, leading to better health outcomes. Fuhrman delves into how high-nutrient diets not only extend lifespan but also enhance the quality of life, by promoting better mental clarity, reduced inflammation, and improved immunity. By understanding the relationship between nutrients and caloric intake, one can address both weight and health issues, achieving a healthier and longer life. #NutrientRichDiet #LifespanExtension #CaloricBalance

In this episode, we talk about 5 red flags to look out for in the intuitive eating space on social media and how to know what is right or wrong when you are first starting your journey to improving your relationship with food and your body. If you struggle with trusting your body around food, you don't want to miss this episode! APPLY FOR GROUP COACHINGFollow on Instagram5 Mistakes I Made When I Started Intuitive Eating

This podcast episode focuses on PCOS and the lifestyle changes that can make a positive impact on the lives of individuals with this condition. PCOS is a common endocrine issue in reproductive women, characterized by hormone imbalances and inflammation. Nurse Doza emphasizes the importance of tracking monthly cycles in-depth, including duration, pain, discomfort, clotting, and other factors. They highlight the significance of considering the monthly cycle as a "report card" that reflects a woman's lifestyle and body's response to it. Additionally, the host suggests tracking hormone levels through lab work to identify specific hormone imbalances and address them effectively. By actively tracking cycles and hormones, individuals with PCOS can gain a better understanding of their condition and make targeted lifestyle changes to improve their quality of life.   TIMESTAMPS: 00:00: START 01:12: Explanation of PCOS as a combination of hormone imbalances and inflammation. 03:44: Emphasizing the need to track hormones through lab work. 07:15: Recommendation of resveratrol as a supplement for PCOS. 11:13: Recommendation of cold exposure to help with hormone balance. 13:14: Recommendation of fasting as a way to reset metabolism and regulate hormones. 17:50: Emphasis on the benefits of fasting for PCOS. 19:39: Reiteration of the importance of tracking hormones and monthly cycle.   We're excited to introduce Mitochondriac, a revolutionary supplement designed to support your body's mitochondrial health. Perfect for anyone looking to enhance their energy levels and overall wellness. Stay tuned to learn more about managing PCOS and discover how Mitochondriac can be a game-changer in your health journey. https://www.mswnutrition.com/products/mitochondriac/?ref=nursedoza PCOS Management Show Notes: Tracking Your Cycle: Essential for understanding PCOS-related fertility issues. Note days, duration, pain, clotting, cramps, and changes in flow. Study: Mayo Clinic - PCOS Tracking Hormone Labs: Important hormones to monitor: Insulin, DHEA-s, Estradiol, Testosterone, Cortisol, A1c, Lipids. The link between obesity and PCOS complications. Study: Mayo Clinic - PCOS Resveratrol Supplementation: Significant decrease in DHEA-S and fasting insulin levels with resveratrol intake[^1^]. Effective in reducing testosterone, LH, and DHEAS levels in women with PCOS[^3^]. Potential disease-modifying effect in PCOS observed in transvaginal ultrasound studies[^4^]. Studies: PubMed on Resveratrol Springer Link on Androgen Production NCBI on Resveratrol and PCOS PubMed on Resveratrol and PCOS Cold Exposure Benefits: The role of adiponectin, leptin, and AMPK in ovarian function[^1^]. BAT transplantation reversing anovulation and hyperandrogenism in PCOS models[^2^]. Insulin resistance, a common feature in PCOS, linked with reduced BAT activity. Studies: Biomed Central on Ovarian Function PNAS on BAT and PCOS Fasting for PCOS: The role of moderate caloric restriction in preventing and reversing PCOS symptoms. Benefits of fasting on insulin sensitivity and hormone regulation[^4^]. Study: NCBI on Caloric Restriction and PCOS   As we wrap up this enlightening episode, let's focus on energizing our body at the cellular level with Mitochondria. This supplement is crafted to bolster your mitochondrial health, ensuring that your cells function optimally. Whether you're dealing with PCOS or simply seeking to boost your vitality, Mitochondria is your ally. Experience the difference with enhanced energy and wellness. Click https://www.mswnutrition.com/products/mitochondriac/?ref=nursedoza and start supporting your body's powerhouses today.

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We are aware of the benefits of both intermittent fasting and caloric restriction when it comes to weight loss and health.   But what happens when we combine these two approaches?   A recent study claims to be the first to explore this combination, and today I will discuss the findings and provide my insights.   Tune in to today's #CabralConcept 2812 to learn about combining intermittent fasting and caloric restriction and how you can incorporate that into your diet.  Enjoy the show and let me know what you thought!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/2812 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

We are aware of the benefits of both intermittent fasting and caloric restriction when it comes to weight loss and health.   But what happens when we combine these two approaches?   A recent study claims to be the first to explore this combination, and today I will discuss the findings and provide my insights.   Tune in to today's #CabralConcept 2812 to learn about combining intermittent fasting and caloric restriction and how you can incorporate that into your diet.  Enjoy the show and let me know what you thought!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/2812 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

In this podcast, Nurse Doza shares his passion for discussing weight loss and offers helpful tips for those on a weight loss journey. He talks about the importance of finding a supportive community, provides recommendations for supplements and blood work, and highlights the benefits of taking supplements.   TIMESTAMPS: 00:00 START 02:50 Find a supportive weight loss community. 05:29 Importance of community for weight loss. 10:58 Sleep is crucial for weight loss. 19:17 Resveratrol helps regulate insulin. 24:29 Calorie restriction aids weight loss. 34:09 Fasting can help with weight loss and prediabetes. 39:23 Cold exposure promotes weight loss. 44:33 Adiponectin promotes prevention of diseases. 49:26 Supplements for weight loss   Before we dive into today's exciting topic on weight loss strategies, let me introduce you to "Mitochondriac." It's a cutting-edge methylated resveratrol supplement that's gaining popularity for supporting metabolism and cellular health. If you've been on the lookout for a supplement to support your weight loss journey, don't miss out on Mitochondriac! Click the link below to explore more. https://www.mswnutrition.com/products/mitochondriac/?ref=nursedoza   Show Notes: 1. The Importance of Community in Weight Loss Finding a community that supports your weight loss journey can be pivotal for success¹. Reference: Diabetes Journals - Obesity Management¹. 2. The Sleep-Weight Connection Obesity is a significant component contributing to sleep apnea¹. Lifestyle factors, such as diet and exercise, play crucial roles in managing obesity¹. Weight change directly correlates with sleep disordered breathing¹. Short sleep duration and prolonged working hours are linked with obesity in certain demographics¹. Sleep deprivation can alter hunger hormone levels, predisposing individuals to obesity¹. Reference: NCBI - Sleep and Obesity¹. 3. Supplement Spotlight: Resveratrol Resveratrol may improve insulin sensitivity and has potential in diabetes management¹. Resveratrol mimics caloric restriction, promotes energy expenditure, and lowers body fat³. References: PubMed - Resveratrol and Diabetes¹. NCBI - Resveratrol Metabolic Effects². NCBI - Resveratrol Anti-obesity Bioactive³. 4. Diet Recommendation: Caloric Restriction (CR) Diet Caloric restriction has shown to be more effective than fat restriction¹. CR improves lifespan, health span, insulin sensitivity, and reduces inflammation⁴. The benefits of CR are amplified when combined with exercise, especially for active individuals³. References: PubMed - Dietary Fat Restriction vs. Caloric Restriction¹. PubMed - Dietary Restriction for Obesity². Frontiers in Physiology - CR and Exercise³. NCBI - Benefits of Caloric Restriction⁴. 5. Harnessing Brown Fat for Weight Loss Brown adipose tissue (BAT) has potential therapeutic benefits due to its energy-expending properties². Cold exposure activates BAT, leading to increased energy expenditure². Adipokines like Adiponectin and Leptin play roles in obesity and energy balance². References: NCBI - Human Brown Adipose Tissue¹. NCBI - BAT, Adipokines, and Obesity². NCBI - Leptin and Its Role³. Mitochondriac To wrap things up, I want to give a shoutout once again to "Mitochondriac." It's not just another supplement; it's a game-changer. Packed with the power of methylated resveratrol, Mitochondriac is here to support your metabolic health and weight loss efforts. Ready to feel the difference? Click on the link below and give Mitochondriac a try. Your body will thank you! https://www.mswnutrition.com/products/mitochondriac/?ref=nursedoza

On this episode of the Flex Diet Podcast, Dr. Kurt Escobar, who holds a Ph.D. in exercise physiology, is not just a trainer and consultant but also a well-versed guide in the realm of nutrition and research. He busts the hype and sheds light on what autophagy truly is. The episode takes a deep dive into the fascinating interplay between caloric restriction, VO2 max, and lean muscle mass and their collective implications on longevity.Head over to https://miketnelson.com and sign up for my geeky, almost daily email newsletter about how to add muscle, increase your performance, and improve body comp, all without destroying your health.Episode notes:[7:13] What is autophagy?[14:54] Predictors of longevity[19:25] Does fasting increase autophagy?[32:41] The problem with believing what you see on social media[38:31] Focus on outcomes[45:53] Fasting and muscle mass[51:58] Dr. Escobar's current research projectsConnect with Dr. Escobar:CSU Long Beach Physiology of Exercise Sport Lab (PEXS) InstagramCal State Long Beach exercise science programBiology Beards and Barbells WebsiteBiology Beards and Barbells YouTubeAbout Dr. Escobar:Dr. Kurt Escobar is an Assistant Professor of Exercise Physiology and co-director of the Physiology of EXercise and Sport (PEXS) Lab at California State University, Long Beach.

In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. For the full show notes, including articles, books, and other resources, visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman Levels: https://levels.link/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dr. Peter Attia, Journal Club 00:03:27 Sponsors: Helix Sleep & Levels 00:06:11 Dreams 00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose 00:19:47 Type 2 Diabetes & Causes, Insulin Resistance 00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study 00:36:19 Sponsor: AG1 00:37:15 TAME Trial; Demographics, Twin Cohort 00:44:27 Metformin & Mortality Rate 00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power 01:01:17 Sponsor: InsideTracker 01:02:23 Hazard Ratios, Censoring 01:09:00 Metformin Advantage?, Variables, Interventions Testing Program 01:16:02 Berberine, Acarbose, SGLT2 Inhibitors 01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers 01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information 01:38:10 Article #2, Belief Effects vs. Placebo Effect 01:45:22 Nicotine Effects 01:51:07 Nicotine Doses & Belief Effects, fMRI Scan 02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects 02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers 02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect 02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac Disclaimer

We're thrilled to bring you this conversation with Hannah Went all about aging, biological clocks and epigenetics! She brings incredible insight into the options for testing your biological age, thoughts on telomere testing, the biggest drivers of aging, and what we can learn from the Dunedin pace of aging test. Tune in if you're interested in extending your healthspan! Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. During that time, she had multiple research internships studying cell signaling and cell biology. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation based age diagnostics and started TruDiagnostics in 2020. TruDiagnostic is a company focusing on methylation array-based diagnostics for life extension and preventive healthcare serving functional medicine providers. TruDiagnostic has a commitment to research with over 30 approved clinical trials investigating the epigenetic methylation changes of longevity and health interventions. Since TruDiagnostic's inception, they have created one of the largest private epigenetic health databases in the world with over 15,000 patients tested to date. Hannah has since created Everything Epigenetics where she shares insights on how DNA regulation has an impact on your health.SHOW NOTES:0:51 Welcome to the show!1:45 Pop Quiz of the Day3:48 Non-Alcoholic Alternatives4:33 Kava & Kratom4:59 The emotional benefits of alcohol7:18 STUDY: Alcohol & Amygdala8:04 Hannah Went's Bio9:38 Welcome Hannah!10:38 How do Epigenetics affect Healthspan15:30 Steve Horvath & Biological Age17:24 Dr. Morgan Levine & 2nd Generation Clocks18:58 Is Telomere testing still valuable?22:04 Senolytics for Senescent Cells25:07 NEW STUDY: Predicting Age in Women28:30 Measuring Spermidine levels28:25 Epigenetic vs Blood/Serum Testing30:33 Spermidine, NMN, NR & Rapamycin33:55 Caloric Restriction & Dunedin PACE35:20 *Magnesium Breakthrough*37:30 The nuances of fasting/feeding39:28 Stress, thoughts & mindset on Aging40:20 3rd Generation Clock: Dunedin PACE44:35 The “Rejuvenation Olympics”45:50 Pregnancy, Illness & Surgeries47:01 How else can we slow the aging process?48:28 Effect of green space on aging50:04 How detrimental is alcohol?55:24 Sleep deprivation & age57:24 Transgenerational Epigenetic Inheritance59:52 Are we all doomed?1:02:35 How can we be more pro-active?1:03:22 Lab Grown Meat1:07:21 Her final piece of advice1:07:55 Where to find more of her!1:08:19 Thanks for tuning in!RESOURCES:Website: Everything EpigeneticsWebsite: TruDiagnosticIG: Everything Epigenetics Email: hannah@everythingepigenetics.comMagnesium Breakthrough - code: BIOHACKERBABES10Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here!   FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins!   THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's episode, Dr. Scott and Tommy explore how fasting has transformed their lives and share actionable steps. They review a study comparing intermittent fasting plus early time-restricted eating with calorie restriction for at-risk individuals. The importance of consistent fasting strategies, even small decisions adding up over time, and much more.   Show Transcript: www.thefastingforlife.com/blog Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here!   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them Article Links: https://www.mdpi.com/2079-7737/12/3/372# https://pubmed.ncbi.nlm.nih.gov/34389873/ https://www.health.harvard.edu/heart-health/what-is-heart-rate-variability https://www.whoop.com/thelocker/whoop-proven-most-accurate-wearable-in-heart-rate-heart-rate-variability-measurements/ https://pubmed.ncbi.nlm.nih.gov/31558032/ https://pubmed.ncbi.nlm.nih.gov/26277879/  

In this episode we discuss: The factors that affect thyroid hormone production, conversion, transport, and uptake How high TSH levels cause damage to the thyroid gland High-carb diets vs. low-carb diets for thyroid health Why restricting calories is not the way to go if you're struggling with hypothyroidism The effects of PUFA and endotoxin on thyroid hormone activity The problems with both deficiencies and excesses of iron, iodine, and vitamin A for thyroid health   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-96-avoid-low-carb-diets-fasting-and-caloric-restriction-if-you-have-hypothyroidism-hypothyroidism-part-2/   Timestamps: 0:00 – intro  1:28 – the factors that affect thyroid hormone production, conversion, transport, and uptake 3:45 – the impact of stress on thyroid hormone production and conversion  5:02 – how the stress hormones and inflammatory cytokines affect thyroid hormone production and conversion 16:44 – thyroid hormones increase sensitivity to stress hormones  21:44 – elevated free fatty acids, especially PUFA, inhibit thyroid hormone binding 23:26 – how a lack of energy prevents the cells from taking up thyroid hormone 30:00 – how oxidative stress affects thyroid hormone production and the effects of TSH on oxidative stress 38:25 – how a low-carb diet affects thyroid hormone production and conversion, causing a hypothyroid state; high-carb diets vs. low-carb diets for thyroid health 47:46 – insulin resistance is associated with reduced thyroid hormone conversion, but this doesn't mean you should avoid carbohydrates   51:39 – how caloric restriction affects thyroid status 55:04 – the effects of fasting on thyroid status 56:42 – T3 has positive feedback on its own production and what this means for thyroid hormone replacement 1:00:01 – the effects of PUFA and endotoxin on thyroid hormone activity 1:04:30 – the effects of micronutrients, specifically iron, vitamin A, selenium, and iodine, on thyroid hormone production, conversion, and activity 1:16:30 – increased thyroid activity increases macronutrient and micronutrient needs, but also improves micronutrient retention in the long-term 1:19:15 – the effects of environmental toxins (pesticides, industrial chemicals, heavy metals, etc.) on thyroid hormone production, conversion, and activity 1:25:20 – the effect of sleep on thyroid hormone production and conversion 

***JOIN THE FASTING LIFESTYLE CHALLENGE THAT STARTS JUNE 7TH, 2023! New to fasting or want to get back on track? Struggling to break through a plateau? Ready to finally stop obsessing about your diet? Let's kick off the summer with intention, habit-building, and fast-tracking your fasting results! We'll teach you how to FAST to LOSE FAT for good, and use 'fast cycling' to achieve uncommon results! Join us on JUNE 7th for the 7-Day Fasting Lifestyle Challenge!  REGISTER HERE! Click the Link for DATES, DETAILS, and FAQ!  June 7th CHALLENGE REGISTRATION LINK   FREE RESOURCE - DOWNLOAD THE NEW  BLUEPRINT TO FASTING FOR FATLOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins!   THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD   In today's episode, Dr. Scott and Tommy discuss intermittent fasting and protein pacing and how they are superior to caloric restriction, and what is Visceral Fat and protein pacing.   Show Transcript: www.thefastingforlife.com/blog   Nutrisense CGM LINK to Discount - Get $30 off and one-month free dietician support with the PROMO CODE “FASTINGORLIFE” www.nutrisense.io/fastingforlife   Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply!   Fasting For Life Community - Join HERE   New to the podcast and wondering where to start? Head to the website and download our  Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice!   Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD   If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them   Reference Links to Articles: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166203/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107279/