DNA located in cellular organelles called mitochondria
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3 episodes with Mitochondrial DNA
4 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
2 episodes with Mitochondrial DNA
Fatigue isn't just a side effect of modern life—it can be a sign of something far deeper. In this episode, Dr. Odell uncovers the complex world of Chronic Fatigue Syndrome and its surprising link to the powerhouses of our cells: the mitochondria. You'll discover how mitochondrial dysfunction may lie at the heart of the brain fog, muscle pain, and post-exertional crashes that define this debilitating condition. We explore the latest science behind energy production, how viruses and inflammation disrupt mitochondrial function, and why fatigue often lingers long after an illness. More importantly, we offer practical, evidence-based strategies for supporting your mitochondrial health—from targeted nutrients and antioxidants to lifestyle therapies and cutting-edge emerging treatments. Whether you live with chronic fatigue or are just curious about how your body makes—and loses—energy, this episode will transform the way you think about fatigue and healing.
Whose Hair is it? Mitochondrial DNA Findings by Karl Miyasako Shakes Up the Trial Senior DNA Analyst Karl Miyasako from Bode Technology reveals groundbreaking mitochondrial DNA test results, indicating John O'Keefe cannot be excluded as the source of the mysterious hair found at the scene. Defense attorney Alan Jackson counters, highlighting the possibility it belongs to John's nephew, introducing crucial reasonable doubt. Could this revelation undermine confidence in the prosecution's case? Hashtags: #KarenReadRetrial #MitochondrialDNA #HairEvidence #CourtroomTwists #ForensicAnalysis #TrueCrimeTrial #LegalStrategy #KarenReadDefense Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Hidden Killers With Tony Brueski | True Crime News & Commentary
Whose Hair is it? Mitochondrial DNA Findings by Karl Miyasako Shakes Up the Trial Senior DNA Analyst Karl Miyasako from Bode Technology reveals groundbreaking mitochondrial DNA test results, indicating John O'Keefe cannot be excluded as the source of the mysterious hair found at the scene. Defense attorney Alan Jackson counters, highlighting the possibility it belongs to John's nephew, introducing crucial reasonable doubt. Could this revelation undermine confidence in the prosecution's case? Hashtags: #KarenReadRetrial #MitochondrialDNA #HairEvidence #CourtroomTwists #ForensicAnalysis #TrueCrimeTrial #LegalStrategy #KarenReadDefense Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Whose Hair is it? Mitochondrial DNA Findings by Karl Miyasako Shakes Up the Trial Senior DNA Analyst Karl Miyasako from Bode Technology reveals groundbreaking mitochondrial DNA test results, indicating John O'Keefe cannot be excluded as the source of the mysterious hair found at the scene. Defense attorney Alan Jackson counters, highlighting the possibility it belongs to John's nephew, introducing crucial reasonable doubt. Could this revelation undermine confidence in the prosecution's case? Hashtags: #KarenReadRetrial #MitochondrialDNA #HairEvidence #CourtroomTwists #ForensicAnalysis #TrueCrimeTrial #LegalStrategy #KarenReadDefense Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
Most people have no idea that something as tiny as algae is one of the most powerful foods for longevity, energy, and hormone balance. But what if just a few tiny tablets a day could support your mitochondria (those little powerhouses in your cells), detoxify your body, and even ease menopause symptoms? Catharine Arnston, algae expert and Founder of ENERGYbits®, breaks down the science behind spirulina and chlorella—two superfoods packed with antioxidants, protein, and essential nutrients for women's health. We're talking detoxification, hormone support, and even slowing down aging—yes, really! Catharine breaks it all down in the simplest way, so you'll walk away knowing exactly why mitochondria are the secret to balancing hormones and feeling your best. We chat about how spirulina protects your cells from stress and damage, why chlorella is a natural detoxifier your body craves, and how both can support estrogen, progesterone, and overall vitality. She even shares super easy ways to add these into your routine without overhauling your life. If you've ever felt like your body isn't bouncing back the way it used to, this conversation is a must-listen. And if you're ready to get serious about taking back control of your hormones, my Magic Menopause program was made for you. It's all about natural, practical ways to feel like yourself again—because you deserve to feel amazing at every stage. Head over to dranna.com to learn more! Key Timestamps: [00:00:00] Introduction. [00:02:34] Hormone detox with key nutrients. [00:05:50] Algae – the most nutrient dense alkaline food. [00:09:03] Spirulina as a brain food and chlorella as a gut health food. [00:10:50] Mitochondria and cellular energy. [00:13:50] Mitochondrial DNA and free radicals. [00:19:09] Spirulina's superoxide dismutase benefits. [00:21:34] Progesterone and ovarian function. [00:27:02] Spirulina as world hunger solution. [00:28:23] Phycocyanin's cancer cell effects. [00:31:28] How much spirulina and chlorella to take. [00:32:14] Chlorella aids with sleep troubles. Memorable Quotes: "90% of inflammation is in the mitochondria, and inflammation is a marker of accelerated aging and indicative of chronic disease. So I tell people, mitochondria are where the rubber hits the road." [00:10:42] – Catharine Arnston "One gram of algae has the same nutrition as a thousand grams of vegetables." [00:34:31] – Catharine Arnston Links Mentioned: Magic Menopause Program: https://order.magicmenopause.com/ Energy Bits (Use code DRANNA to get 20% off): https://dranna.com/energybits The Miracle of Algae: The Future of Fast Food And Reversing the Aging Process With Catharine Arnston https://drannacabeca.com/blogs/podcast/the-miracle-of-algae-the-future-of-fast-food-and-reversing-the-aging-process-with-catharine-arnston Connect with Catharine Arnston: Website: https://energybits.com/ Instagram: https://www.instagram.com/energybits/ & https://www.instagram.com/beautybits Facebook: https://www.facebook.com/ENERGYbits/ TikTok: https://www.tiktok.com/@energybits Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca Produced by Evolved Podcasting: www.evolvedpodcasting.com
Most people have no idea that something as tiny as algae is one of the most powerful foods for longevity, energy, and hormone balance. But what if just a few tiny tablets a day could support your mitochondria (those little powerhouses in your cells), detoxify your body, and even ease menopause symptoms? Catharine Arnston, algae expert and Founder of ENERGYbits®, breaks down the science behind spirulina and chlorella—two superfoods packed with antioxidants, protein, and essential nutrients for women's health. We're talking detoxification, hormone support, and even slowing down aging—yes, really! Catharine breaks it all down in the simplest way, so you'll walk away knowing exactly why mitochondria are the secret to balancing hormones and feeling your best. We chat about how spirulina protects your cells from stress and damage, why chlorella is a natural detoxifier your body craves, and how both can support estrogen, progesterone, and overall vitality. She even shares super easy ways to add these into your routine without overhauling your life. If you've ever felt like your body isn't bouncing back the way it used to, this conversation is a must-listen. And if you're ready to get serious about taking back control of your hormones, my Magic Menopause program was made for you. It's all about natural, practical ways to feel like yourself again—because you deserve to feel amazing at every stage. Head over to dranna.com to learn more! Key Timestamps: [00:00:00] Introduction. [00:02:34] Hormone detox with key nutrients. [00:05:50] Algae – the most nutrient dense alkaline food. [00:09:03] Spirulina as a brain food and chlorella as a gut health food. [00:10:50] Mitochondria and cellular energy. [00:13:50] Mitochondrial DNA and free radicals. [00:19:09] Spirulina's superoxide dismutase benefits. [00:21:34] Progesterone and ovarian function. [00:27:02] Spirulina as world hunger solution. [00:28:23] Phycocyanin's cancer cell effects. [00:31:28] How much spirulina and chlorella to take. [00:32:14] Chlorella aids with sleep troubles. Memorable Quotes: "90% of inflammation is in the mitochondria, and inflammation is a marker of accelerated aging and indicative of chronic disease. So I tell people, mitochondria are where the rubber hits the road." [00:10:42] – Catharine Arnston "One gram of algae has the same nutrition as a thousand grams of vegetables." [00:34:31] – Catharine Arnston Links Mentioned: Magic Menopause Program: https://order.magicmenopause.com/ Energy Bits (Use code DRANNA to get 20% off): https://dranna.com/energybits The Miracle of Algae: The Future of Fast Food And Reversing the Aging Process With Catharine Arnston https://drannacabeca.com/blogs/podcast/the-miracle-of-algae-the-future-of-fast-food-and-reversing-the-aging-process-with-catharine-arnston Connect with Catharine Arnston: Website: https://energybits.com/ Instagram: https://www.instagram.com/energybits/ & https://www.instagram.com/beautybits Facebook: https://www.facebook.com/ENERGYbits/ TikTok: https://www.tiktok.com/@energybits Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca Produced by Evolved Podcasting: www.evolvedpodcasting.com
Hey Heal Squad! If you've been feeling drained, sluggish, or just downright exhausted, this episode is for YOU! The Roundtable is here, tackling one of the hottest health topics —FATIGUE! Maria, Dr. Alison, Deidre, and Christina are here to uncover why it's so often misdiagnosed, how cholesterol might be playing a sneaky role, and whether you're actually fatigued or just plain tired. Yes, there's a BIG difference! But don't worry—we're not leaving you hanging! The Squad is sharing expert tips to beat fatigue, reclaim your energy, and finally feel like yourself again. And get this… Dr. Alison has NEVER felt fatigued! Spoiler Alert: it doesn't involve naps! Just wait until you hear her secret. Enjoy, Heal Squad! -- HEAL SQUAD SOCIALS IG: https://www.instagram.com/healsquad/ TikTok: https://www.tiktok.com/@healsquadxmaria HEAL SQUAD RESOURCES: Heal Squad Website: https://www.healsquad.com/ Maria Menounos Website: https://www.mariamenounos.com My Curated Macy's Page: Shop My Macy's Storefront AquaTru: https://aquatruwater.com/ code: HEALSQUAD Prenuvo: Prenuvo.com/MARIA for $300 off Sleep Number: https://www.sleepnumber.com/ ROUNDTABLE RESOURCES & HEADLINES: Douglas C Wallace & Mitochondrial DNA : https://pubmed.ncbi.nlm.nih.gov/26406369/ Listen to Maria's Healing Journey in the DR & More on Dr Jack Kruse: https://www.healsquad.com/foundational-health ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content (published or distributed by or on behalf of Maria Menounos or http://Mariamenounos.com and http://healsquad.com) is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions. This podcast is presented for exploratory purposes only. Published content is not intended to be used for preventing, diagnosing, or treating a specific illness. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment.
Prof. Sarah Camargos interviews Prof. Sun Ju Chung about his recent paper in the Movement Disorders Journal investigating diagnostic and prognostic capabilities of measuring blood mitochondrial DNA copy number (mtDNA-CN) for Parkinson's disease. Journal CME is available until March 3, 2026 Read the article.
CrimeCast Podcast Mashup! (find all our conversations at: www.thecrimecast.com) Attorney Lee Davis - joins David and Clint in studio to talk about a precedent setting case! The State vs. Paul Ware - the rape and murder of a 4 year old girl! Courtroom processes - testimonies - trips to FBI headquarters - pressure to get it right when using new technology - and much more! They also covered a few other cases that impacted the use of DNA cases moving forward! PLUS - why did Lee move from the prosecution side to the criminal defense side! MORE about the case - In September 1996, a new evidence tool was used for the FIRST TIME in a United States courtroom. Mitochondrial DNA (mtDNA) evidence was introduced in a Tennessee murder prosecution against twenty-seven-year-old Paul Ware. Without the mtDNA results there was only circumstantial evidence pointing to Ware as the suspect in the rape and murder of a fouryear-old girl. The defense claimed that another man in the home, the babysitter, had framed Ware, who was found drunk and asleep next to the body of the child. Policing & the Community - Cold/Active Cases - Safety Tips - Famous/Infamous Cases - Special Guests AND all Wrapped in Entertainment and Stories! Share us with your friends - leave us reviews - help us spread the word! - Hosted by Clint Powell and David Roddy Please consider leaving us a review on Apple and giving us a share to your friends! Powered by: https://www.kubotaofchattanooga.com/ Sponsored by: MedicareMisty - https://www.medicaremisty.com/ This podcast is powered by ZenCast.fm
For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr, Richard Frye https://drfryemdphd.comCV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdfRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3DihubAutism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495 0:00 Dr. Richard Frye6:13 Intro into mitochondria & energy production, various disease & dysfunction11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)54:54 Future Research59:58 Wrap up, Reviews/RatingsX: https://twitter.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com
Refs Front mmunol.2019; 10: 1064 Fosdick and Poulton 1956. Love me Tender https://youtu.be/v5SkY9WHekg?si=q5Xhq32IHBNYdj81 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
In this episode of Research Like a Pro, Diana and Nicole explore the use of mitochondrial DNA (mtDNA) and WikiTree in genealogical research. They explain that mtDNA is inherited from our mothers, with only females passing it on, and how it differs from autosomal DNA by coming from a distant maternal ancestor. They discuss how mtDNA testing reveals haplogroups, genetic population groups with a common ancestor, and share their personal testing experiences with 23andMe, FamilyTree DNA, and Living DNA, highlighting the northern European origins of their haplogroup, U5b1c2b. The hosts emphasize that while mtDNA changes very little over generations, making it difficult to pinpoint recent common ancestors, it is useful for confirming or refuting specific female ancestral lines. They discuss integrating DNA information into WikiTree, a collaborative and free online platform, which allows users to add mtDNA haplogroups to family profiles, enhancing genealogical research by sharing DNA data with other researchers. They provide practical tips for getting started on WikiTree, including creating a login, adding ancestors, and integrating DNA information from various testing services. They also highlight unique features of WikiTree, such as the DNA Ancestors view, which shows the inheritance of different types of DNA from ancestors. This episode offers valuable insights into using mtDNA and WikiTree as powerful tools in genealogical research. Links https://www.wikitree.com/ Honoring my Matrilineal Grandmothers: A Look at Mitochondrial DNA - https://familylocket.com/honoring-my-matrilineal-grandmothers-a-look-at-mitochondrial-dna/ WikiTree and My Mitochondrial DNA - https://familylocket.com/wikitree-and-my-mitochondrial-dna/ Sponsor – Newspapers.com For listeners of this podcast, Newspapers.com is offering new subscribers 20% off a Publisher Extra subscription so you can start exploring today. Just use the code “FamilyLocket” at checkout. Research Like a Pro Resources Airtable Universe - Nicole's Airtable Templates - https://www.airtable.com/universe/creator/usrsBSDhwHyLNnP4O/nicole-dyer Airtable Research Logs Quick Reference - by Nicole Dyer - https://familylocket.com/product-tag/airtable/ Research Like a Pro: A Genealogist's Guide book by Diana Elder with Nicole Dyer on Amazon.com - https://amzn.to/2x0ku3d 14-Day Research Like a Pro Challenge Workbook - digital - https://familylocket.com/product/14-day-research-like-a-pro-challenge-workbook-digital-only/ and spiral bound - https://familylocket.com/product/14-day-research-like-a-pro-challenge-workbook-spiral-bound/ Research Like a Pro Webinar Series 2024 - monthly case study webinars including documentary evidence and many with DNA evidence - https://familylocket.com/product/research-like-a-pro-webinar-series-2024/ Research Like a Pro eCourse - independent study course - https://familylocket.com/product/research-like-a-pro-e-course/ RLP Study Group - upcoming group and email notification list - https://familylocket.com/services/research-like-a-pro-study-group/ Research Like a Pro with DNA Resources Research Like a Pro with DNA: A Genealogist's Guide to Finding and Confirming Ancestors with DNA Evidence book by Diana Elder, Nicole Dyer, and Robin Wirthlin - https://amzn.to/3gn0hKx Research Like a Pro with DNA eCourse - independent study course - https://familylocket.com/product/research-like-a-pro-with-dna-ecourse/ RLP with DNA Study Group - upcoming group and email notification list - https://familylocket.com/services/research-like-a-pro-with-dna-study-group/ Thank you Thanks for listening! We hope that you will share your thoughts about our podcast and help us out by doing the following: Write a review on iTunes or Apple Podcasts. If you leave a review, we will read it on the podcast and answer any questions that you bring up in your review. Thank you! Leave a comment in the comment or question in the comment section below. Share the episode on Twitter, Facebook, or Pinterest. Subscribe on iTunes, Stitcher, Google Podcasts, or your favorite podcast app. Sign up for our newsletter to receive notifications of new episodes - https://familylocket.com/sign-up/ Check out this list of genealogy podcasts from Feedspot: Top 20 Genealogy Podcasts - https://blog.feedspot.com/genealogy_podcasts/
Short Outtake from CrimeCast - The 1st Trial Using Mitochondrial DNA with Attorney Lee Davis! Give all our episodes a listen: www.thecrimecast.com Please consider supporting the podast by becoming a Patron: https://www.patreon.com/duringthebreakpodcast THANK YOU TO OUR SPONSORS: Granite Garage Floors of Chattanooga: https://granitegaragefloors.com/location/chattanooga Vascular Institute of Chattanooga: https://www.vascularinstituteofchattanooga.com/ The Barn Nursery: https://www.barnnursery.com/ Optimize U Chattanooga: https://optimizeunow.com/chattanooga/ Alchemy Medspa and Wellness Center: http://www.alchemychattanooga.com/ Chattanooga Concrete: www.chattanoogaconcreteco.com Roofingco.com: www.roofingco.com Please consider leaving us a review on Apple and giving us a share to your friends! This podcast is powered by ZenCast.fm
Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process Thanks for tuning in! Book An Intro Coaching Call with Chloe Porter Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
In this episode, my guest is Natalie Crawford, MD, a double board-certified physician specializing in obstetrics and gynecology, fertility and reproductive health and host of the “As a Woman” podcast. We discuss female hormones, nutrition, supplementation, reproductive health, and fertility, including how the timing and duration of puberty impact a woman's long-term hormone cycles and menopause. We also discuss the pros and cons of various birth control methods and how hormonal vs. non-hormonal birth control each affects fertility. We cover the factors that impact egg and sperm quality and how to leverage timing for conception. We also discuss procedures to assess female fertility, including egg count and hormone testing, the process of egg freezing, in vitro fertilization (IVF) and other reproductive options. This episode represents fairly comprehensive coverage of female hormones and reproductive health, highlighting important tests and screening, behavioral, nutritional, supplement and prescription-based tools that women of any age can use to improve their fertility, hormone function and overall health. For the full show notes, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Natalie Crawford (00:01:40) Sponsors: Maui Nui Venison & Helix Sleep; The Brain Body Contract (00:04:59) Female Puberty & Growth Characteristics, Height (00:13:27) Eggs & Ovulation, Harvesting Eggs, In Vitro Fertilization (IVF) (00:17:31) Endocrine Disruptors, Fetal Development (00:21:39) Lavender, Tea Tree & Evening Primrose Oils, Scents, Diapers (00:25:13) Breast Milk vs. Formula & Fertility (00:26:04) Menstruation Cycle & Hormones, Timing (00:34:08) Sponsor: AG1 (00:35:59) Estrogen, Progesterone & Menstrual Cycle (00:38:08) Hormonal Birth Control & Ovarian Reserve, AMH Testing, Fertility (00:42:42) Spermatogenesis & Testosterone; Heat: Ovaries vs Testes (00:46:11) Period & Pregnancy, Conception Window (00:48:56) Estrogen, Libido & Ovulation; Mittelschmerz (00:51:33) Tool: Intercourse Timing & Conception; Artificial Insemination, IVF (00:55:03) Egg/Sperm Quality, Cigarettes, Vaping, Cannabis & Alcohol (01:02:20) Sponsor: InsideTracker (01:03:29) Intrauterine Device (IUD), Depo-Provera & Fertility (01:10:00) Birth Control Risks & Benefits, Cancers, Polycystic Ovarian Syndrome (PCOS) (01:19:39) Blood Clotting & Birth Control Pill; Health Screening (01:24:50) Tool: AMH Testing, Ovarian Reserve, Antral Follicle Count Ultrasound (01:29:55) IVF, In Vitro Maturation (IVM); Early Ovarian Reserve Screening (01:35:40) Tools: Egg Freezing, IVF; Age & Egg Quality (01:43:37) Egg Freezing & IVF Procedures, Maternal Age, Success Rates (01:51:30) Tool: Sperm Freezing & Paternal Age, Vasectomy (01:55:01) Hormones, Egg Freezing & IVF (02:00:42) Three-Parent IVF, Mitochondrial DNA (02:05:21) IVF Embryo Storage & Donation; Donor Education & Consent (02:14:29) Autism, Developmental Disorders, IVF Babies, Age (02:20:36) Tools: Sleep, Nutrition & Fertility; Dietary Fat (02:27:32) Protein, Meat, Tofu, Fish; Sugar, Artificial Sweeteners; Weight & Miscarriage (02:37:38) Tools: Supplements; Prenatal Vitamins, Omega 3s, Vitamin D, Coenzyme Q10 (02:42:26) L-Carnitine & Male Fertility; PCOS & Myo-inositol; Metformin (02:47:11) Egg Retrieval, Ovarian Hyperstimulation Syndrome, Minimal Stimulation (02:57:56) INVOcell (03:03:12) Egg Freezing, Intracytoplasmic Sperm Injection (ICSI), Sperm Fragmentation (03:11:45) Genetic Testing, IVF Transfer & Success Rate, Embryo Banking (03:15:10) Menopause (03:19:47) Hormone Replacement Therapy & Menopause (03:22:25) Early-signs of Menopause (03:25:18) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
In episode 58 of C60 Health Connections, we discuss best practices to support your anti-aging or healthy aging goals, including C60 + supplement stacking to support your mitochondrial health. If you are over the age of 30, this conversation is dedicated to you! Dr Anthony Capasso, MD has over 25 years of experience practicing Lifestyle medicine and is the owner and founder of Thin MD Med Spas in Jacksonville, FL. He is an athlete who is an expert in nutrition, hormonal health, mitochondrial health. People from around the US seek him out for his expertise in anti-aging, weight loss, hormonal health, and immune support. He's been voted #1 Physician in Jacksonville, he's a national speaker for Anti-Aging medicine and serves as the official nutritionist for the Jacksonville Armada Professional Football Club. If you are interested in trying Dr. Anthony Capasso's Mitoblast2, go to https://www.mitoblast.com/ and use the coupon code - SAVE15 - to save 15% at checkout.
The exploration into the secrets of aging continues in this much-anticipated second part of our conversation with Dr. Joel Rothman from UCSB's Center for Aging and Longevity Studies (CALS). Join Buck as they dive further into the fascinating breakthroughs that are setting the stage for a potential revolution in human longevity. Tune in to episode 33 for a straightforward, yet enlightening discussion on the future of aging. 00:00:53 - Understanding Mitochondria 00:04:32 - Mitochondria and Aging 00:04:56 - Mitochondrial DNA 00:09:15 - Mitochondrial Dysfunction 0:09:48 - Removing Damaged Mitochondria 0:13:54 - Mitochondrial DNA and Aging 0:15:57 - Epigenetics and Aging 0:17:36 - Exploring Other Mechanisms Related To Longevity 0:19:08 - Understanding Stress Response 0:19:25 - Types of Stress 0:20:32 - Stress Response Systems in Cells 0:21:08 - Manipulating Stress Response 0:21:54 - Artificially Activating Stress Response 000:22:38 - Stress Response and Aging 00:23:43 - Hormesis and Longevity 00:24:32 - Heat and Cold Stress 00:25:29 - Interplay of Different Factors 00:26:07 - Studying Aging in Worms 00:26:28 - Debate on Aging Research 00:32:36 - Ethical Implications of Longevity Research 00:34:14 - Addressing Ethical Concerns 00:35:40 - Potential Issues with Extended Lifespan 00:38:18 - Longevity and Population Growth 00:39:28 - Ethical Considerations of Extending Lifespan 00:40:42 - Impact on Population Growth 00:42:02 - Predictions for Future Access to Technology
How does mitochondrial health affect the body's overall health? Today, the Founder and Chief Science Officer of C60, Ken Swartz joins me to discuss mitochondrial health in the body. We discuss the power of the mitochondria, its connection to oxidative radicals and the positive impact supplements like C60 can have on the mitochondria. Ken Swartz, aka “Ken the Scientist,” is the founder and Chief Science Officer of C60 Power, a health and wellness company committed to delivering the highest quality Carbon 60 products available. Ken earned a Master of Science degree from the University of Colorado at Denver and a Bachelor of Science in Economics from Arizona State University. He spent the early part of his career as a secondary school teacher, and he continues to be passionate about helping and educating people. Ken has run several research science laboratories over the course of his career and discovered C60 while developing the MOXY fusion reactor. During his research, he became aware of the powerful free radical neutralizing properties of C60. He first began using C60 as a radiation protectant while leading a fusion research project. About 8 months after Ken started taking C60, he had a positive experience occur with his health.* Ken's personal experience with C60 was so profound that he decided to dedicate himself to the research, study, and manufacturing of C60 Buckminsterfullerene products. In 2016, Ken founded C60 Power which offers 99.99% pure sublimated Carbon 60, (never exposed to solvents), delivered in 100% certified organic oils, made in the USA. Ken believes that “your health is your responsibility” and he is on a mission to help people feel empowered to take control of their health. Use the Coupon Code: THEC60SHOW for 10% off your first #Carbon60 order at: https://shopc60.com Check out the research studies here: https://shopc60.com/research, and here https://whatisc60.org Connect with us: Facebook - https://www.facebook.com/c60purplepow... Instagram - https://www.instagram.com/c60purplepo... Twitter - https://twitter.com/c60purplepower Search for us (“C60 Purple Power”) on any of your favorite alternative social media channels, too! Disclaimer: These statements and products have not been evaluated by the Food and Drug Administration. The information on this show, and C60 Purple Power products, are not intended to diagnose, treat, cure, mitigate, or prevent disease.
Unlocking the Secrets of Mitochondrial DNA: The Tiny Power Generators of Our Cells**See the video https://www.drhughwegwerth.com/post/revealing-the-truth-about-mitochondrial-dna-the-unprotected-powerhouses-inside-our-cells**Episode Introduction: The Origin of Our Cells**Welcome, young explorers! Prepare to have your minds blown by a fantastic story about the tiny engines in our bodies, the mitochondria. When Mother Nature was making her blueprint of life, she put DNA in our cells, not just in the central part, the nucleus, but also in our mitochondria. Imagine this - each tiny cell in your body is like a busy city filled with 500 to 2000 mitochondria!- **An intriguing journey into our body's smallest workers, the mitochondria**- **Discover how Mother Nature put DNA in two places in our cells**- **Picture our cells as bustling cities full of mitochondria****Diving into the Mitochondrial Mystery**Our adventure today takes us into a fantastic research study that reveals some secrets about our mitochondrial DNA. It shows that mitochondrial DNA gets more extensive and longer-lasting damage compared to nuclear DNA when they face something called oxidative stress. And oxidative stress is just a fancy way of saying the usual wear and tear of life.- **Exploring a significant research study about mitochondrial DNA**- **Learning about the impact of oxidative stress on our DNA**- **Understanding oxidative stress as a part of everyday life****The Safe Zone: Our Nuclear DNA**Now, let's take a look at our nuclear DNA. Imagine it like a top-security vault, like Fort Knox, but for DNA. The DNA inside your nucleus is protected, much like precious gold in a safe.- **Visualizing the DNA inside our nucleus**- **Understanding the nucleus as a top-security vault for our DNA****The Underdogs: Our Mitochondrial DNA**But now, let's turn to the mitochondrial DNA. Picture it like a big green ball (that's the mitochondrion) with DNA inside it. The surprising fact? This DNA has no protection. It's out in the open with no armor.- **Examining the mitochondrial DNA**- **Understanding the vulnerability of mitochondrial DNA without any protection****Impact of Oxidative Stress on Mitochondrial DNA**And what does this mean for your health? It means that anything causing oxidative stress or inflammation can harm your DNA. Yes, your mitochondrial DNA is always at risk, like a sitting duck to these harmful things. - **Discussing the consequences of oxidative stress on mitochondrial DNA**- **Relating the risks to our health and wellbeing**Getting to know these basics helps us look after these tiny power generators inside our cells. This way, we can keep our bodies running smoothly for a long time. So, tune in to this episode, and let's dive deep into the secrets of our cells!- **Emphasizing the importance of understanding these basics**- **Encouraging listeners to tune in and learn more about their own bodies**
The DU Podcast visits with Dr. Brian Davis, Mississippi State University, and Dr. Phil Lavretsky, University of Texas El Paso, to discuss the latest discoveries in duck genetics and how these are changing our traditional view of mallard populations. New research shows westward expansion of game-farm mallard genes and reveals potential impacts on behavior, morphology, and potentially migration. So what's the big deal and how might this impact the future of waterfowl management? Listen in and find out!www.ducks.org/DUPodcast
News items read by Laura Kennedy include: Mitochondrial DNA analysis suggests early Asian migrations to the Americas and Japan (details) 400-year-old-skeleton unearthed in Maryland believed to be discarded remains of teenaged indentured servant (details) Decline of the Indus Civilization megacities likely due to long periods of drought (details) Preserved 7,000-year-old road discovered beneath the Adriatic Sea (details) (details)
Do you like this podcast? Let Greg know! You can leave a few words at ratethispodcast.com/openloopsThe episode is CONTROVERSIAL. Not DILBERT bad, but you'll disagree with things, you'll be angered, bothered, disgusted, shocked, relieved, and wonder if the limits of free speech have gone too far.That said, if what guest Klanmother Karen-Anne Lucyk MacDonald told Greg is true, the tribunal elders are actually overseeing everything and tribunal law doesn't seem to care too deeply about deleting shows from the podcast directories.Greg was AFRAID to put this on the air, as he explains at the beginning (and there's a surprise at the end, too!).But, why is this so dangerous to put out there? We'll tell you why. Greg and Karen-Ann discuss: MK Ultra Project, Biofeedback Machines, Quantum Healing, Spiritual Practices, Mitochondrial DNA, Secret Service SSP, Stargate, Ecovillages, Galactic Races, Treaties, Tribunal Judges, Genetics, Pre-Constitution History, Natural Law, Sovereignty, Human Trafficking, Neurolinguistic Programming, Sound, Light, Essential Oils, Genius Biofeedback, Aluminum Mesh, Smart Meters, Radiation, Solar Panels, Monitors, Chat Rooms, Scalar Technology, iTerohertz, Core Box, Blue and Red Light Therapy, Energy Weapons, Antarctica, Havana Syndrome, Abductions, Gene Prints, Yoni Steams, Pelvic Hydrotherapy, Sweat Lodges, Herbs, Vibrational Frequencies, Creator's Law, Blood Type, DNA Frequency, Quantum Computer Systems, Wisdom Keepers, Court System, Medical Industry, Religious Histories, Politics, Herbal Remedies, Pyramids, and whoops, almost forgot....Suppositories,May you never return to your same way of thinking about reality ever again. And how could you? It's Open LoopsKaren-Anne's Links: facebook:https://www.facebook.com/ka.lucyk.7project incension:https://www.youtube.com/user/022367ASMyoutube: https://www.youtube.com/@karen-annlucykmacdonald7777/streams4 starter GENIUS bioscan videoshttps://vimeo.com/showcase/6224293beginner phone app GENIUS/PEMF /TERA linkshttps://geniusbiofeedback.com/?rfsn=5201588.e7905dhttps://newsinsideout.com/?s=karen+macdonaldhttps://exopolitics.blogs.com/international_criminal_co/https://rumble.com/search/all?q=karen%20lucyk%20macdonaldhttps://rumble.com/search/all?q=geniusbiofeedback%20karen%20%20macdonald
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Given the biblical accounts of Creation and the Flood, can we draw any conclusions about what we would expect in genetics? That depends on status of the species in question (e.g., 'clean' vs 'unclean and 'on the Ark' vs 'not on the Ark'), its population history, the amount of created diversity initially engineered into that species/kind, difference in mutation rates and DNA repair systems, and things like that. In the end, no, we cannot make many direct predictions, yet much of the genetic data and observations still point straight to the Bible. The biblical model is expansive enough to take in a range of observations. Notes and links: Tallulah Gorge Orphan Brigade Park Jeanson N. 2015. Mitochondrial DNA clocks imply linear speciation rates within "kinds”. Answers Research Journal 8:273–304. Jeanson N. 2013. Recent, functionally diverse origin for mitochondrial genes from ~2700 metazoan species. Answers Research Journal 6:467–501. Carter R. How to think (not what to think), Creation.com, 1 Nov 2016. Carter R. 2019. A successful decade for Mendel's Accountant, J Creation 33(2):51–56. Carter R. Species were designed to change, part 3: the tangled web of (intrabaraminic) life, Creation.com, 12 Aug 2021. The Amazing Braided Baramin Concept is Intrinsic to Creation (Species were designed to change, part 4) on BiblicalGenetics.com.
Given the biblical accounts of Creation and the Flood, can we draw any conclusions about what we would expect in genetics? That depends on status of the species in question (e.g., 'clean' vs 'unclean and 'on the Ark' vs 'not on the Ark'), its population history, the amount of created diversity initially engineered into that species/kind, difference in mutation rates and DNA repair systems, and things like that. In the end, no, we cannot make many direct predictions, yet much of the genetic data and observations still point straight to the Bible. The biblical model is expansive enough to take in a range of observations. Notes and links: Tallulah Gorge Orphan Brigade Park Jeanson N. 2015. Mitochondrial DNA clocks imply linear speciation rates within "kinds”. Answers Research Journal 8:273–304. Jeanson N. 2013. Recent, functionally diverse origin for mitochondrial genes from ~2700 metazoan species. Answers Research Journal 6:467–501. Carter R. How to think (not what to think), Creation.com, 1 Nov 2016. Carter R. 2019. A successful decade for Mendel's Accountant, J Creation 33(2):51–56. Carter R. Species were designed to change, part 3: the tangled web of (intrabaraminic) life, Creation.com, 12 Aug 2021. The Amazing Braided Baramin Concept is Intrinsic to Creation (Species were designed to change, part 4) on BiblicalGenetics.com.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.28.526030v1?rss=1 Authors: Schwartz, A. Z., Nance, J. Abstract: The mitochondrial genome (mtDNA) is packaged into discrete protein-DNA complexes called nucleoids. mtDNA packaging factor TFAM (mitochondrial transcription factor-A) promotes nucleoid compaction and is required for mtDNA replication. Here, we investigate how changing TFAM levels affects mtDNA in the Caenorhabditis elegans germ line. We show that increasing germline TFAM activity boosts mtDNA number and significantly increases the relative proportion of a selfish mtDNA mutant, uaDf5. We conclude that TFAM levels must be tightly controlled to ensure appropriate mtDNA composition in the germ line. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
In this video Dr Cohen talks CohBar, a company that he co-founded with Professor Nir Barzilai and some of the work they are doing, as well as the latest developments in his lab. He also discusses the need for precision medicine in addressing diseases of aging. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/
In this video Dr Cohen talks about how mitochondria age and how they are not all the same but different in each tissue. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research. Mitochondria-derived peptides in aging and healthspan https://pubmed.ncbi.nlm.nih.gov/35499074/ Dr Cohen's page at USC https://gero.usc.edu/faculty/cohen/ The Cohen Lab https://gero.usc.edu/labs/cohenlab/ CohBar Inc. Web site https://www.cohbar.com/
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.30.517979v1?rss=1 Authors: Pena, N., Gonzalez-Hunt, C., Qi, R., Barlow, C., Shanks, N. F., Carlisle, H., Sanders, L. H. Abstract: Pathogenic mutations in LRRK2 cause Parkinson's disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in clinical trials. We recently found that G2019S LRRK2 causes mitochondrial DNA (mtDNA) damage and treatment with multiple classes of LRRK2 kinase inhibitors at concentrations associated with dephosphorylation of LRRK2 reversed mtDNA damage to healthy control levels. Because maintaining the normal function of LRRK2 in heterozygous G2019S LRRK2 carriers while specifically targeting the G2019S LRRK2 activity could have an advantageous safety profile, we explored the efficacy of a G2019S mutant selective LRRK2 inhibitor to reverse mtDNA damage in G2019S LRRK2 models and patient cells relative to non-selective LRRK2 inhibitors. Potency of LRRK2 kinase inhibition by EB-42168, a G2019S mutant LRRK2 kinase inhibitor, and MLi-2, a nonselective inhibitor, was determined by measuring phosphorylation of LRRK2 at Ser935 and/or Ser1292 using quantitative western immunoblot analysis. The Mito DNADX assay, a novel system that allows for the accurate real-time quantification of mtDNA damage in a 96-well platform, was performed in parallel. We confirmed that EB-42168 selectively inhibits LRRK2 phosphorylation on G2019S LRRK2 relative to wild-type LRRK2. On the other hand, MLi-2 was equipotent for wild-type and G2019S LRRK2. Acute treatment with EB-42168 inhibited LRRK2 phosphorylation and also restored mtDNA damage to healthy control levels. Precision medicine is a common approach in modern day cancer research that is not yet routinely applied to neurodegenerative diseases. Abrogation of mtDNA damage with mutant selective tool inhibitor EB-42168 demonstrates the promise of a precision medicine approach for LRRK2 G2019S PD. Levels of mtDNA damage may serve as a potential pharmacodynamic biomarker of altered kinase activity that could be useful for small molecule development and clinical trials. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
The previous episode showed how homicide detectives solved 50-year-old cold cases. They analyzed old evidence using new DNA extraction technology pioneered by Othram, a forensic genealogy lab in Texas. Othram provided new leads by finding relatives of suspects on genealogy databases. As revolutionary as that seems, it was just a few years ago that the FBI pioneered the use of mitochondrial DNA in a Texas murder case. Mitochondrial DNA is handed down from mother to child, so it can only tell you about your maternal ancestors. In a landmark case, former U.S. prosecutor Bill Johnston used the mitochondrial DNA from a single hair to send a killer to prison for the rest of his life. Here's the backstory of how he did it. FOLLOW the True Crime Reporter® Podcast SIGN UP FOR my True Crime Newsletter THANK YOU FOR THE FIVE-STAR REVIEWS ON APPLE Please leave one – it really helps. TELL ME about a STORY OR SUBJECT that you want to hear more about
In the previous episode, we showed how homicide detectives solved 50-year-old cold cases. They analyzed old evidence by using new DNA extraction technology pioneered by Othram, a forensic genealogy lab in Texas. Othram provided new leads by finding relatives of suspects on genealogy databases. As revolutionary as that seems, it was just a few years ago that the FBI pioneered the use of mitochondrial DNA in a Texas murder case. Mitochondrial DNA is handed down from mother to child, so it can only tell you about your maternal ancestors. In a landmark case, former U.S. prosecutor Bill Johnston used the mitochondrial DNA from a single hair to send a killer to prison for the rest of his life. Here's the backstory of how he did it. We want to become your favorite true crime podcast. Please leave a review wherever you listen. Join our true crime community and follow us here. The True Crime Reporter® podcast features stories about serial killers, mass murderers, murder mysteries, homicides, cold cases, prisons, violent criminals, serial rapists, child abductors, child molesters, kidnappers, bank robbers, cyber criminals, and assorted violent criminals. True Crime Reporter® is a @2022 copyrighted and trade-marked production by True Crime Reporter®, LLC, in Dallas, Texas. See omnystudio.com/listener for privacy information.
In the previous episode, we showed how homicide detectives solved 50-year-old cold cases. They analyzed old evidence using new DNA extraction technology pioneered by Othram, a forensic genealogy lab in Texas. Othram provided new leads by finding relatives of suspects on genealogy databases. As revolutionary as that seems, it was just a few years ago that the FBI pioneered the use of mitochondrial DNA in a Texas murder case. Mitochondrial DNA is handed down from mother to child, so it can only tell you about your maternal ancestors. In a landmark case, former U.S. prosecutor Bill Johnston used the mitochondrial DNA from a single hair to send a killer to prison for the rest of his life. Here's the backstory of how he did it.
Bob Phelps has been working in the GMO watchdog scene for many years. He founded Gene Ethics in 1988 to work for a GM-free future. Bob is an educator and campaigner in peace and environment movements, with forty years experience. In 2003 he was awarded a Federation Medal for his services to the Australian community. Gene Ethics is a non-profit educational network of citizens and kindred groups. We want the precautionary principle, scientific evidence and the law rigorously applied to all proposed uses of genetic manipulation (GM) technologies and their products. Gene Ethics generates and distributes accurate information and analysis on the ethical, environmental, social and economic impacts of GM. Our education programs critically assess GM for the public, policy-makers and interest groups.
Today on the podcast, Mason is joined by Osteopath and long-time friend Cole Clayton. Cole is a unique and brilliant osteopath with a specialised interest in breathing and paediatric cranio-facial growth. He is also the creator of Baseline Breathing- an education programme for those wanting to journey into understanding the practical application of breathing physiology and breathing techniques. As someone who grew up suffering from undiagnosed sleep-disordered breathing, Cole is passionate about helping kids with the inextricably linked sleep/breath/behavioural problems realise their innate intelligence through breathing and airway early intervention. This conversation provides a fascinating insight into child development issues of the face, tongue, and airways that translate into sleep and breathing issues. If you're a mouth breather or want to understand what's at play on a deeper level underneath the inability to breathe through the nose (with ease)- I highly recommend tuning in to this episode. Cole also shares why he deeply aligns with cranial osteopathy. A philosophy of osteopathy that works with embryological growth forces, and honours the body's inherent wisdom and self-healing capacity. Scroll down to explore the fascinating topics discussed in this episode, and check out the resources at the bottom of the page for links to Cole's course and all specifics mentioned in this episode. Cole and Mason discuss: -Pneumopedics. -Jaw pain and hearing. -Cranio-facial osteopathy. -The blocked nose epidemic. -Embryology and osteopathy. -Mitochondrial DNA damage. -How sleep impacts behaviour. -How Cole works with the body. -How our breath affects everything. -Skull and airway underdevelopment. -Cole's baseline breathing programme. -Child development, sleep and breathing. -Conception, birth and growth development. -Honouring the body's ability to heal itself. Resource guide Guest: Cole's website Bay Osteopathy Dr. Levis Clinic Baseline Breathing Course Mentioned in this episode: The Uncharted Body- Book by Dr. Daniel Keown Breathe- The New Science Of a Lost Art (book by James Nestor) Tonics for Spring: MSM Schisandra I AM GAIA BEAUTY BLEND Deer Antler Velvet Relevant Podcasts: Transcending The God Matrix with George Kavassilas (EP#119) The Cosmic Adventure of Life- George Kavassilas on The Mason Taylor Show Health In a Technologically Connected World- Jason Bawden-Smith on The Mason Taylor Show Check Out The Transcript Below: https://www.superfeast.com.au/blogs/articles/cole-clayton-ep-183
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.12.511955v1?rss=1 Authors: Newman, L. E., Tadepalle, N., Novak, S. W., Schiavon, C. R., Rojas, G. R., Chevez, J. A., Lemersal, I., Medina, M., Rocha, S., Towers, C. G., Grotjahn, D. A., Manor, U., Shadel, G. S. Abstract: Maternally inherited mitochondrial DNA (mtDNA) encodes essential subunits of the mitochondrial oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation1. This function of mtDNA contributes to antiviral resistance, but unfortunately also causes pathogenic inflammation in many disease contexts2. Cells experiencing mtDNA stress due to depletion of the mtDNA-packaging protein, Transcription Factor A, Mitochondrial (TFAM), or HSV-1 infection exhibit elongated mitochondria, mtDNA depletion, enlargement of nucleoids (mtDNA-protein complexes), and activation of cGAS/STING innate immune signaling via mtDNA released into the cytoplasm3. However, the relationships between altered mitochondrial dynamics and mtDNA-mediated activation of the cGAS-STING pathway remain unclear. Here, we show that entire enlarged nucleoids are released from mitochondria that remain bound to TFAM and colocalize with cGAS. These nucleoids arise at sites of mtDNA replication due to a block in mitochondrial fission at a stage when endoplasmic reticulum (ER) actin polymerization would normally commence, which we propose is a fission checkpoint to ensure that mtDNA has completed replication and is competent for segregation into daughter mitochondria. Released nucleoids also colocalize with the early endosomal marker RAB5 as well as the late endosomal marker RAB7 in TFAM-deficient cells and in response to mtDNA stress caused by the HSV-1 UL12.5 protein. Loss of RAB7 increases interferon stimulated gene (ISG) expression. Thus, we propose that defects in mtDNA replication and/or segregation enact a late mitochondrial fission checkpoint that, if persistent, leads to selective removal of dysfunctional nucleoids by a mitochondrial-endosomal pathway. Early steps in this pathway are prone to mtDNA release and cGAS-STING activation, but the immunostimulatory mtDNA is ultimately disposed of through a mechanism involving RAB7-containing late endosomes to prevent excessive innate immune signaling. This mtDNA quality control pathway might represent a therapeutic target to prevent mtDNA-mediated inflammation and associated pathology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
This week we discuss mitochondrial DNA and its importance in aging with Amy Vandiver (@AmyVandiver2). We also highlight a new method to quickly sequence full length mitochondrial DNA allowing for mitochondrial genome comparisons and the understanding of the diversity between mitochondrial DNA. As usual we also discuss the process of pre-printing, preLights and how they can generate collaborations. As well as understanding more about the MD PhD group leader route. Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.23.480720v2.full This episode was produced by Emma Wilson and edited by Jonny Coates. Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated. For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com. Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.
References Mechanisms of Ageing and Development.2006. Volume 127, Issue 9, Pages 705-718 J Bioenerg Biomembr. 2015 April ; 47(1-2): 173–188 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
Tools for Testing Mitochondrial Disorders: The Latest Advances in Genetics and Genomics Guest speaker Dr. Richard Boles from Children's Hospital Los Angeles and Courtagen Life Sciences, Inc. to discuss: What is genomic sequencing and how does it change testing for mitochondrial disorders? Is NextGen testing appropriate for all people with suspected mitochondrial disease? How can DNA sequencing change information available about family inheritance of mitochondrial diseases? Do advances in genomic sequencing impact treatment options for Mito patients? About The Speaker: Dr. Boles completed medical school at UCLA, a pediatric residency at Harbor-UCLA, and a genetics fellowship at Yale. He is board certified in Pediatrics, Clinical Genetics and Clinical Biochemical Genetics. His current positions include Associate Professor of Pediatrics at the Keck School of Medicine at USC, Director of the Metabolic and Mitochondrial Disorders Clinic at Children's Hospital Los Angeles, and Medical Director at Courtagen Life Sciences Inc. Dr. Boles practices the "bedside to bench to bedside" model of a physician-scientist, combining a very active clinical practice in metabolic and mitochondrial disorders with basic research as Director of a mitochondrial genetics laboratory at the Saban Research Institute. Dr. Boles' clinical and research focus is on polymorphisms (common genetic changes) in the maternally-inherited mitochondrial DNA, and with new technology in the nuclear DNA (chromosomes), and their effects on the development of common functional disorders. Examples include migraine, depression, cyclic vomiting syndrome, complex regional pain syndrome, autism and SIDS. He has 50 published papers on mitochondrial disease. Dr. Boles is responsible for the final review of DNA sequences at Courtagen.
How do you identify human remains? Neil deGrasse Tyson and Chuck Nice explore DNA and the task to identify the remains of missing soldiers with biomedical scientist Tim McMahon and forensic anthropologist Franklin Damann. What is the DPAA? NOTE: StarTalk+ Patrons can watch or listen to this entire episode commercial-free here: https://startalkmedia.com/show/forensics-dna-and-identifying-missing-soldiers/Thanks to our Patrons Jon Scherer, Thibault Deckers, Jimmy Jam, Evan Cooper, Barnato, Justin Ross, James Nichols, Lori, Emilie Talles, and Roy Slettbakk for supporting us this week.Photo Credit: Doctoroftcm, CC0, via Wikimedia Commons
Extreme Genes - America's Family History and Genealogy Radio Show & Podcast
Host Scott Fisher opens the show with David Allen Lambert, Chief Genealogist of the New England Historic Genealogical Society and AmericanAncestors.org. David begins by sharing news that he has been featured in an article about his witch ancestor in London's Guardian newspaper. In Family Histoire News, an Englishman has learned he descends from some Bidens. Those Bidens! Now he wants an invitation to the White House! Then, another metal detectorist in the UK has made quite a find… in his own backyard. Catch what he discovered. Then, another member of the famous Von Trapp family has passed away. David next talks about a unique type of DNA analysis that has proven the descendancy of the great grandson of Sitting Bull. And finally… a World War I ammunition shell has been found to be loaded… with many things other than powder and weaponry. Find out what was in it! Next, Paul Woodbury of Legacy Tree Genealogists visits with Fisher for two segments. The first talks about mitochondrial DNA. What can you use it for in your research? And what might be expecting too much? Paul explains. In part two, Paul Woodbury discusses “confirmation bias.” Are you guilty of confirming your researching by an incorrect analysis? Paul explains what NOT to do as you begin your genetic genealogy. Then, David returns for two rounds of Ask Us Anything. That's all this week on Extreme Genes, America's Family History Show!
Rudolph deel Evert die SKOKKENDE nuus oor sy familie :-D Lees die artikel hier. Anton Petrov - The entire human genome finally sequenced (youtube) How DNA Codons only code for 20 amino acids (www) Locke Movie Trailer (youtube) Mitochondrial DNA (www)
Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study. The post Changes to mitochondrial DNA spur autism-like traits in mice appeared first on Spectrum | Autism Research News.
Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study.
Mummies! Mitochondrial DNA! Austrian crystals! All these treasures and more in this week’s episode with Afiya Augustine (Adult-ish podcast), whose muse is most decidedly back in town.Note: We had some minor audio difficulties in this recording. We did our best to remove every pop and distortion from the recording but there may be a few that slipped through. Thanks for listening!
Ohio has its first success in identifying skeletal remains using a technology not previously available to the state's crime labs. Twenty-two-year-old Dewayne Lewis went missing from his Toledo home in 2013. This spring, hunters discovered human bones. In November, detectives at the Bureau of Criminal Investigations (BCI) were able to identify those remains as Lewis thanks to a partnership with the global research and development organization Battelle. Battelle picked out the instrumentation and processes that would work best for BCI to take mitochondrial DNA and test it using massively parallel sequencing. Mitochondrial DNA lives in the energy pockets of the cells and is passed down on the mother's side. It's present in tens of thousands of copies of every cell in the body, and because there are so many, scientists are able to generate a profile even when they don't have much to work with, as was the case of Dewayne Lewis. "We now may be able to match, identify them with a missing
V dnešnom podcaste si povieme novinky o fosfáne na Venuši (hovorili sme o tom v Pseudocaste #470), o zlých správach o teleskope Arecibo a zaujímavosti o mitochondrálnej DNA. Pseudocast 479 na YouTube Zdroje Prospects for Life on Venus Fade—but Aren’t Dead YetLegendary Arecibo telescope will close forever — scientists are reelingBiparental Inheritance of Mitochondrial DNA in HumansMitochondrial DNA can be inherited from fathers, not just mothersDoes It Matter That the DOD Released Those UFO Videos?The Tale of the TapeCOVID vaccine excitement builds as Moderna reports third positive result
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.13.381475v1?rss=1 Authors: Pabis, K. Abstract: The "theory of resistant biomolecules" posits that long-lived species show resistance to molecular damage at the level of their biomolecules. Here, we test this hypothesis in the context of mitochondrial DNA (mtDNA) as it implies that predicted mutagenic DNA motifs should be inversely correlated with species maximum lifespan (MLS). First, we confirmed that guanine-quadruplex (GQ) and direct repeat (DR) motifs are mutagenic, as they associate with mtDNA deletions in the human major arc of mtDNA, while also adding mirror repeat (MR) and intramolecular triplex motifs to a growing list of potentially mutagenic features. What is more, triplex motifs showed disease-specific associations with deletions and an apparent interaction with GQ motifs. Surprisingly, even though DR, MR and GQ motifs were associated with mtDNA deletions, their correlation with MLS was explained by the biased base composition of mtDNA. Only triplex motifs negatively correlated with MLS and these results remained stable even after adjusting for body mass, phylogeny, mtDNA base composition and effective number of codons. Taken together, our work highlights the importance of base composition for the comparative biogerontology of mtDNA and suggests that future research on mitochondrial triplex motifs is warranted. Copy rights belong to original authors. Visit the link for more info
For a long time, biologists believed that our DNA resided only in the nucleus, the large organelle acting as the control centre in our cells. It wasn't until 1963, when scientists Margrit and Sylvan Nass at Stockholm University discovered DNA fibres in mitochondria using electron microscopy. Our mitochondrial DNA (mtDNA) accounts for a small portion of our total DNA. In fact, it contains just 40 of the 20,000 to 25,000 protein-coding genes in our body, however, it is notably distinct from nuclear DNA. Unlike nuclear DNA, which comes from both parents, mitochondrial DNA comes only from the mother. In this podcast, I explain the significance of this key biological difference, and explore what other roles this fascinating molecule plays in our bodies. (With thanks to our sponsor 'Curriculum Press' for providing content for this podcast)
Beverly Mok is a graduate student at Harvard University. She currently studies chemistry and chemical biology at Harvard University and is a member of the Liu Lab at the MIT and Harvard Broad Institute. Her research work is centered around mitochondrial DNA gene editing. Publication: https://www.nature.com/articles/s4158... --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/idris-sunmola/support
One of our great friends and an up and coming intellectual, Charlotte Daniels takes us through some mind-blowing knowledge bombs that are sure to blow you away. From new movie ideas to first date guides, this episode has it all! Please listen to Charlotte's new song "It's Pretty F*****g Hard to Be Alone" on Apple Music and Spotify! Apple Music: https://music.apple.com/us/album/its-pretty-f-g-hard-to-be-alone-single/1506297966 Spotify: https://open.spotify.com/album/5HajsbENXMC6ycK78wVYAT?si=Kox917v7SSO6jvsAzliZAw You can find us @secretbunkerpod on IG and Twitter, The Secret Bunker Podcast on Youtube, Reddit, and all podcast hosts. Reach out to us at any of these and thesecretbunkerpodcast@gmail.com as well as leaving audio messages on secretbunkerpodcast.com, which will be live answered on a future episode! Music: Set It Up by Shane Ivers - https://www.silvermansound.com --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/secretbunker/message
Sign up for your FREE trial to The Great Courses Plus here: http://ow.ly/2UGB30qCbvs. Because of the way genetic reprogramming works, it’s hard to make one clone based on an adult cell, and it’s almost impossible to make a second-generation one. Thanks also to our Patreon patrons https://www.patreon.com/MinuteEarth and our YouTube members. ___________________________________________ To learn more, start your googling with these keywords: Cell: The smallest structural and functional unit of an organism. Clone: An organism produced asexually from one ancestor, to which they are genetically identical. DNA: Deoxyribonucleic acid, a self-replicating material that is present in nearly all living organisms as the main component of chromosomes. It is the carrier of genetic information. Embryo: An unborn or unhatched offspring early in the process of development. Enzyme: A substance produced by a living organism that acts as a catalyst to bring about a specific biochemical reaction. Gene: A unit of heredity which is transferred from a parent to offspring. These are encoded within DNA and help determine traits. Genetic Reprogramming: This refers to erasing and remodeling epigenetic marks, such as DNA methylation during mammalian development. Zygote: A diploid cell resulting from the fusion of two haploid gametes ___________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our website: https://www.minuteearth.com/ Say hello on Facebook: http://goo.gl/FpAvo6 And Twitter: http://goo.gl/Y1aWVC And download our videos on itunes: https://goo.gl/sfwS6n ___________________________________________ Credits (and Twitter handles): Script Writer: Cameron Duke (@dukeofcam) Video Director, Narrator, and Script Editor: David Goldenberg (@dgoldenberg) Video Illustrator: Arcadi Garcia Rius (@garirius) With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Ever Salazar, Peter Reich, Julián Gómez, Sarah Berman Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder ___________________________________________ References: Chan, M. M., Smith, Z. D., Egli, D., Regev, A., & Meissner, A. (2012). Mouse ooplasm confers context-specific reprogramming capacity. Nature Genetics, 44(9), 978–980. https://doi.org/10.1038/ng.2382 Dean, W., Santos, F., & Reik, W. (2003). Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Seminars in Cell & Developmental Biology, 14(1), 93–100. https://doi.org/10.1016/s1084-9521(02)00141-6 Evans, M. J., Gurer, C., Loike, J. D., Wilmut, I., Schnieke, A. E., & Schon, E. A. (1999). Mitochondrial DNA genotypes in nuclear transfer-derived cloned sheep. Nature Genetics, 23(1), 90–93. https://doi.org/10.1038/12696 Gao, R., Wang, C., Gao, Y., et al. (2018). Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos. Cell Stem Cell, 23(3), 426–435.e5. https://doi.org/10.1016/j.stem.2018.07.017 Histone Deacetylase - an overview | ScienceDirect Topics. (n.d.). Www.Sciencedirect.Com. Retrieved March 2, 2020, from https://www.sciencedirect.com/topics/neuroscience/histone-deacetylase Hochedlinger, K., & Plath, K. (2009). Epigenetic reprogramming and induced pluripotency. Development, 136(4), 509–523. https://doi.org/10.1242/dev.020867 Hochedlinger, K., Rideout, W. M., Kyba, M., Daley, G. Q., Blelloch, R., & Jaenisch, R. (2004). Nuclear transplantation, embryonic stem cells and the potential for cell therapy. The Hematology Journal, 5, S114–S117. https://doi.org/10.1038/sj.thj.6200435 Lister, R., Pelizzola, M., Kida, Y. S., et al. (2011). Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature, 471(7336), 68–73. https://doi.org/10.1038/nature09798 Morgan, H. D., Santos, F., Green, K., Dean, W., & Reik, W. (2005). Epigenetic reprogramming in mammals. Human Molecular Genetics, 14(suppl_1), R47–R58. https://doi.org/10.1093/hmg/ddi114 Reik, W. (2001). Epigenetic Reprogramming in Mammalian Development. Science, 293(5532), 1089–1093. https://doi.org/10.1126/science.1063443 Srivastava, D., & DeWitt, N. (2016). In Vivo Cellular Reprogramming: The Next Generation. Cell, 166(6), 1386–1396. https://doi.org/10.1016/j.cell.2016.08.055 Wakayama, S., Kohda, T., Obokata, H., et al. (2013). Successful Serial Recloning in the Mouse over Multiple Generations. Cell Stem Cell, 12(3), 293–297. https://doi.org/10.1016/j.stem.2013.01.005 Wakayama, T., Shinkai, Y., Tamashiro, K. L. K., et al. (2000). Cloning of mice to six generations. Nature, 407(6802), 318–319. https://doi.org/10.1038/35030301 Yamanaka, S. (2012). Induced Pluripotent Stem Cells: Past, Present, and Future. Cell Stem Cell, 10(6), 678–684. https://doi.org/10.1016/j.stem.2012.05.005
In episode seven of the 2020 R&D Season, Just Science interviews Kimberly Sturk-Andreaggi, a Research Scientist at the Armed Forces DNA Identification Laboratory, about the development of entire mitogenome reference data using an automated high-throughput sequencing workflow. Disaster victim identification comes with a unique set of hurdles. Poor-quality DNA, decades-old samples, and a lack of relative referential data can make the identification of victims from current and past conflicts challenging. This is the reason that the Armed Forces DNA Identification Laboratory uses mitochondrial DNA as their primary testing method. Stay tuned as our guest discusses the utility of mitochondrial DNA and a method for developing entire mitogenome reference data in this episode of Just Science. This season is funded by the National Institute of Justice’s Forensic Technology Center of Excellence.
Mitochondria lie at the center of life. At conception, we inherit our mother's mitochondrial DNA and our electricity for life is turned on. The mitochondrial journey is much like our life's journey. In fact, as we age the mitochondrial volume and output may start to decline and we then start to experience the effects of aging. In this episode, Dr. Chris Meletis, author of the book, MitoLongevity,speaks with us deeply about the role of mitochondria in health. We discuss the mitochondrial role in the immune system, inflammation, hormonal health, and mental health. We discuss evaluation for mitochondrial decline, nutrition and lifestyle factors, and so much more. enjoy... Show outline 1. Philosophy about Mitochondria 2. Overview of Mitochondria, Mitochondrial DNA, Mitochondrial potential 3. Mitotricity, Inflammaging. immunology , Senescence, Mitochondriopathy 4. Environmental influences on mitochondria from birth and beyond. 5. Mitochondrial dysfunction symptoms: 6. Drugs and conditions with links to Mitochondrial dysfunction 7. Assessment of Mitochondrial Function 8. Mechanism of mitochondrial production of sex hormones 9. COQ10/MitoQ/Niagen/Autism 10. How to mind you manage your mitochondria so they thrive. 11. Mitochondria supportive foods 12. Role of Fat in Mitochondria About our Guest Dr. Chris D. Meletis is an educator, international author and lecturer. His personal mission is “Changing World’s Health One Person at a Time.” He believes that when people become educated about their body, that is the moment when change begins. He has authored over a dozen books and in excess of 200 national scientific articles in such journals and magazines as Natural Health, Alternative and Complementary Therapies, Townsend Letter for Doctors and Patients, Life Extension, Natural Pharmacy and the Journal of Restorative Medicine. Dr. Meletis served as Dean of Naturopathic Medicine and Chief Medical Officer for 7 years at NUNM, the oldest naturopathic medical school in North America. He has received numerous awards including, Physician of the Year by the American Association of Naturopathic Physicians; Excellence Award for his work in treating and advocating for the medically underserved; and most recently a NUNM Hall of Fall award at the State Association’s annual banquet. His passion for helping the underprivileged drove him to spearhead the creation of 16 free natural medicine healthcare clinics in the Portland metropolitan area of Oregon. links: http://mitobook.com/ Minding your mitochondria youtube talk by Terry Wahl, MD #Mitochondria #mitochondrialdisease #mitochondrialdysfunction #mitochondrial #MitochondrialDiseaseAwarenessWeek #mitochondrialdna #mitochondrialhealth --- Support this podcast: https://anchor.fm/adam-rinde/support
There’s one place you can find DNA within your own cells that isn’t the nucleus. What are mitochondria? Why do they have DNA and why don’t all mitochondria throughout the world have the same genes? Let’s learn to be scientifically conversational. For all references and supplemental information, you can navigate to ascienceshow.com.
Today's episode of Research Like a Pro is about how to find your female ancestors. We interview Lisa Lisson, the author of the Are You My Cousin? blog. Lisa shares four helpful strategies to get around the common problems encountered when researching the women in our family tree. Join us as we talk about these proven strategies and unique record types (even cookbooks!). Links Researching Female Ancestors? You Can Overcome Those Research Roadblocks! - by Lisa Lisson at her website The Big Genie List - Lisa's list of resources, databases, and educational opportunities Lisa Lisson's website, social media, and contact: www.LisaLisson.com, Are you My Cousin Facebook Group, Facebook Page, Instagram, Twitter, Youtube, and email: lissongenealogy@yahoo.com Coverture - article on Wikipedia about women being covered by men's legal status when married Mitochondrial DNA - article at the ISOGG Wiki https://researchworks.oclc.org/archivegrid/ https://books.google.com/ https://chroniclingamerica.loc.gov/ Research Like a Pro eCourse Study Group - more information and email list Research Like a Pro: A Genealogist's Guide by Diana Elder with Nicole Dyer on Amazon.com Thank you Thanks for listening! We hope that you will share your thoughts about our podcast and help us out by doing the following: Share an honest review on iTunes or Stitcher. You can easily write a review with Stitcher, without creating an account. Just scroll to the bottom of the page and click "write a review." You simply provide a nickname and an email address that will not be published. We value your feedback and your ratings really help this podcast reach others. If you leave a review, we will read it on the podcast and answer any questions that you bring up in your review. Thank you! Leave a comment in the comment or question in the comment section below. Share the episode on Twitter, Facebook, or Pinterest. Subscribe on iTunes, Stitcher, Google Play, or your favorite podcast app. Sign up for our newsletter to receive notifications of new episodes. Check out this list of genealogy podcasts from Feedspot: Top 20 Genealogy Podcasts
In today's "Ask Kiefer Anything Unfiltered" part 3, he answers questions muscle memory, cancer, radiation treatments, environmental toxins, and allergies. Learn more: https://1b.io/Nq
Meet Deborah Dunn, MD in the 2nd part of her interview. DNA and mitochondria have become such an important health topic and understanding this genetic information can optimize your well being.Deborah received her medical degree from the University of Texas and her master's in applied environmental public health from Tulane University. She completed a fellowship from Dr. Andrew Weil's Integrative Medicine program at the University of Arizona and completed training from The Institute of Functional Medicine. She is the founder of Genetic Eve, a company that interprets Mitochondrial DNA.Subscribe to YOUR TRUTH REVEALED weekly videos on YouTube - https://bit.ly/2MjsfdK➤RESOURCESFree Worksheet: https://www.YourTruthRevealed.comGenetic Eve: https://www.geneticeve.comMindful Self-Compassion https://amzn.to/34eYEHtWorkbook: https://amzn.to/34eYEHtStore: https://bit.ly/2H99Iwl ➤ SUMMARYWhy has DNA become such an interesting topic?There are 4 major reasons why analyzing DNA is popular.* DNA is far more expansive than your hair and eye color.* Analyzing DNA is now more affordable - in 2008 it cost $10 billion and now it can cost $200.* DNA tests are more available.* We're still figuring out the core value of analyzing DNA.What is mitochondrial DNA and its significance?* DNA, short for deoxyribonucleic acid, is the molecule that contains your genetic code.* Mitochondrial DNA is the DNA that is located in mitochondria that creates energy.* Mitochondria are small structures in cells that generate energy for the cell to use and are referred to as the "powerhouses" of the cell.* You inherit mitochondria exclusively from you mom that enables researchers to trace maternal lineage far back in time.How does mitochondrial DNA tie into your maternal haplogroup?* A maternal haplogroup is a family of mitochondrial DNA (mtDNA) that traces back to a single common maternal ancestor.* You share the same maternal haplogroup with any relative you share a direct maternal line with, including your mom, your brother, your maternal aunt, and so on.* Your maternal haplogroup traces back through the generations to a single mutation at a specific place and time to a shared maternal ancestor.How can you determine your maternal haplogroup? The process is easy to have your genetic DNA tested. Contact a testing company, and you will receive a DNA test kit in the mail.* The instructions will ask you to spit into a tube or wipe a swab around the inside of your mouth.* Then you mail the sample of your DNA to the lab.* Know that we all share 99.9% of the same genes. Testing companies show just .1% of your genetic makeup in the report.* These reports predict the ancestral origin of different parts of your DNA by comparing them to reference populations.* The report from 23andMe will provide your maternal haplogroup.Where does the name genetic eve come from?In human genetics, Genetic Eve refers to the the Mitochondrial Eve that is the matrilineal most recent common ancestor of all living human beings.* The most recent woman from whom all living humans descend in an unbroken line purely through your mom and your mom's mom, back until all lines converge on one woman.* The name “Mitochondrial Eve" alludes to biblical Eve.* Dr. Dunn's company is called Genetic Eve.Why does it matter in today's world that you carry ancient maternally inherited mutations?It's possible in the future that we will manipulate our genetics including our mitochondria.* If this happens, the ability to track the ancestry of people will be lost.* Manipulating genetics are life-altering interventions that can change the mitochondria to adapt to this modern world.
Episode 8 is the second part of an interview with Deborah Dunn, MD to know your DNA. DNA and mitochondria have become such an important health topic and understanding this genetic information can optimize your wellbeing. Deborah received her medical degree from the University of Texas and her master’s in applied environmental public health from Tulane University. She completed a fellowship from Dr. Andrew Weil’s Integrative Medicine program at the University of Arizona and completed training from The Institute of Functional Medicine. She is the founder of Genetic Eve, a company that interprets Mitochondrial DNA. Subscribe to YOUR TRUTH REVEALED weekly videos on YouTube - https://bit.ly/2MjsfdK ➤RESOURCES Free Worksheet: https://www.YourTruthRevealed.com Genetic Eve: https://www.geneticeve.com Mindful Self-Compassion https://amzn.to/34eYEHt Workbook: https://amzn.to/34eYEHt Store: https://bit.ly/2H99Iwl ➤ SUMMARY Why has DNA become such an interesting topic? There are 4 major reasons why analyzing DNA is popular. DNA is far more expansive than your hair and eye color. Analyzing DNA is now more affordable - in 2008 it cost $10 billion and now it can cost $200. DNA tests are more available. We’re still figuring out the core value of analyzing DNA. What is mitochondrial DNA and its significance? DNA, short for deoxyribonucleic acid, is the molecule that contains your genetic code. Mitochondrial DNA is the DNA that is located in mitochondria that creates energy. Mitochondria are small structures in cells that generate energy for the cell to use and are referred to as the "powerhouses" of the cell. You inherit mitochondria exclusively from you mom that enables researchers to trace maternal lineage far back in time. How does mitochondrial DNA tie into your maternal haplogroup? A maternal haplogroup is a family of mitochondrial DNA (mtDNA) that traces back to a single common maternal ancestor. You share the same maternal haplogroup with any relative you share a direct maternal line with, including your mom, your brother, your maternal aunt, and so on. Your maternal haplogroup traces back through the generations to a single mutation at a specific place and time to a shared maternal ancestor. How can you determine your maternal haplogroup? The process is easy to have your genetic DNA tested. Contact a testing company, and you will receive a DNA test kit in the mail. The instructions will ask you to spit into a tube or wipe a swab around the inside of your mouth. Then you mail the sample of your DNA to the lab. Know that we all share 99.9% of the same genes. Testing companies show just .1% of your genetic makeup in the report. These reports predict the ancestral origin of different parts of your DNA by comparing them to reference populations. The report from 23andMe will provide your maternal haplogroup. Where does the name genetic eve come from? In human genetics, Genetic Eve refers to the the Mitochondrial Eve that is the matrilineal most recent common ancestor of all living human beings. The most recent woman from whom all living humans descend in an unbroken line purely through your mom and your mom’s mom, back until all lines converge on one woman. The name “Mitochondrial Eve" alludes to biblical Eve. Dr. Dunn’s company is called Genetic Eve. Why does it matter in today’s world that you carry ancient maternally inherited mutations? It’s possible in the future that we will manipulate our genetics including our mitochondria. If this happens, the ability to track the ancestry of people will be lost. Manipulating genetics are life-altering interventions that can change the mitochondria to adapt to this modern world. The study of mitochondrial DNA is memorializing the history of who you are. ➤CONNECT WITH ME All Episodes: https://bit.ly/2NfSst4 Podcast: https://apple.co/2KzQ3rG Instagram: https://bit.ly/2MjShh0 Facebook: https://bit.ly/2z41u4i Business Inquiries: info@erikamarcoux.com ➤ABOUT
Meet Deborah Dunn, MD in the 1st part of her interview. DNA and mitochondria have become such an important health topic and understanding this genetic information can optimize your well being.Deborah received her medical degree from the University of Texas and her master's in applied environmental public health from Tulane University. She completed a fellowship from Dr. Andrew Weil's Integrative Medicine program at the University of Arizona and completed training from The Institute of Functional Medicine. She is the founder of Genetic Eve, a company that interprets Mitochondrial DNA.Subscribe to YOUR TRUTH REVEALED weekly videos on YouTube - https://bit.ly/2MjsfdK➤RESOURCESFree Worksheet: https://www.YourTruthRevealed.comGenetic Eve: https://www.geneticeve.comMindful Self-Compassion https://amzn.to/34eYEHtWorkbook: https://amzn.to/34eYEHtStore: https://bit.ly/2H99Iwl ➤ SUMMARYWhy has DNA become such an interesting topic?There are 4 major reasons why analyzing DNA is popular.* DNA is far more expansive than your hair and eye color.* Analyzing DNA is now more affordable - in 2008 it cost $10 billion and now it can cost $200.* DNA tests are more available.* We're still figuring out the core value of analyzing DNA.What is mitochondrial DNA and its significance?* DNA, short for deoxyribonucleic acid, is the molecule that contains your genetic code.* Mitochondrial DNA is the DNA that is located in mitochondria that creates energy.* Mitochondria are small structures in cells that generate energy for the cell to use and are referred to as the "powerhouses" of the cell.* You inherit mitochondria exclusively from you mom that enables researchers to trace maternal lineage far back in time.How does mitochondrial DNA tie into your maternal haplogroup?* A maternal haplogroup is a family of mitochondrial DNA (mtDNA) that traces back to a single common maternal ancestor.* You share the same maternal haplogroup with any relative you share a direct maternal line with, including your mom, your brother, your maternal aunt, and so on.* Your maternal haplogroup traces back through the generations to a single mutation at a specific place and time to a shared maternal ancestor.How can you determine your maternal haplogroup? The process is easy to have your genetic DNA tested. Contact a testing company, and you will receive a DNA test kit in the mail.* The instructions will ask you to spit into a tube or wipe a swab around the inside of your mouth.* Then you mail the sample of your DNA to the lab.* Know that we all share 99.9% of the same genes. Testing companies show just .1% of your genetic makeup in the report.* These reports predict the ancestral origin of different parts of your DNA by comparing them to reference populations.* The report from 23andMe will provide your maternal haplogroup.Where does the name genetic eve come from?In human genetics, Genetic Eve refers to the the Mitochondrial Eve that is the matrilineal most recent common ancestor of all living human beings.* The most recent woman from whom all living humans descend in an unbroken line purely through your mom and your mom's mom, back until all lines converge on one woman.* The name “Mitochondrial Eve" alludes to biblical Eve.* Dr. Dunn's company is called Genetic Eve.Why does it matter in today's world that you carry ancient maternally inherited mutations?It's possible in the future that we will manipulate our genetics including our mitochondria.* If this happens, the ability to track the ancestry of people will be lost.* Manipulating genetics are life-altering interventions that can change the mitochondria to adapt to this modern world.
Episode 7 is the first part of an interview with Deborah Dunn, MD to know your DNA. DNA and mitochondria have become such an important health topic and understanding this genetic information can optimize your well being. Deborah received her medical degree from the University of Texas and her master’s in applied environmental public health from Tulane University. She completed a fellowship from Dr. Andrew Weil’s Integrative Medicine program at the University of Arizona and completed training from The Institute of Functional Medicine. She is the founder of Genetic Eve, a company that interprets Mitochondrial DNA. Subscribe to YOUR TRUTH REVEALED weekly videos on YouTube - https://bit.ly/2MjsfdK ➤RESOURCESFree Worksheet: https://www.YourTruthRevealed.comGenetic Eve: https://www.geneticeve.comMindful Self-Compassion https://amzn.to/34eYEHtWorkbook: https://amzn.to/34eYEHtStore: https://bit.ly/2H99Iwl ➤ SUMMARYWhy has DNA become such an interesting topic?There are 4 major reasons why analyzing DNA is popular. DNA is far more expansive than your hair and eye color. Analyzing DNA is now more affordable - in 2008 it cost $10 billion and now it can cost $200. DNA tests are more available. We’re still figuring out the core value of analyzing DNA. What is mitochondrial DNA and its significance?DNA, short for deoxyribonucleic acid, is the molecule that contains your genetic code. Mitochondrial DNA is the DNA that is located in mitochondria that creates energy. Mitochondria are small structures in cells that generate energy for the cell to use and are referred to as the "powerhouses" of the cell. You inherit mitochondria exclusively from you mom that enables researchers to trace maternal lineage far back in time. How does mitochondrial DNA tie into your maternal haplogroup?A maternal haplogroup is a family of mitochondrial DNA (mtDNA) that traces back to a single common maternal ancestor. You share the same maternal haplogroup with any relative you share a direct maternal line with, including your mom, your brother, your maternal aunt, and so on. Your maternal haplogroup traces back through the generations to a single mutation at a specific place and time to a shared maternal ancestor. How can you determine your maternal haplogroup? The process is easy to have your genetic DNA tested. Contact a testing company, and you will receive a DNA test kit in the mail. The instructions will ask you to spit into a tube or wipe a swab around the inside of your mouth. Then you mail the sample of your DNA to the lab. Know that we all share 99.9% of the same genes. Testing companies show just .1% of your genetic makeup in the report. These reports predict the ancestral origin of different parts of your DNA by comparing them to reference populations. The report from 23andMe will provide your maternal haplogroup. Where does the name genetic eve come from?In human genetics, Genetic Eve refers to the the Mitochondrial Eve that is the matrilineal most recent common ancestor of all living human beings. The most recent woman from whom all living humans descend in an unbroken line purely through your mom and your mom’s mom, back until all lines converge on one woman. The name “Mitochondrial Eve" alludes to biblical Eve. Dr. Dunn’s company is called Genetic Eve. Why does it matter in today’s world that you carry ancient maternally inherited mutations?It’s possible in the future that we will manipulate our genetics including our mitochondria. If this happens, the ability to track the ancestry of people will be lost. Manipulating genetics are life-altering interventions that can change the mitochondria to adapt to this modern world. The study of mitochondrial DNA is memorializing the history of who you are. ➤CONNECT WITH MEAll Episodes: https://bit.ly/2NfSst4Podcast: https://apple.co/2KzQ3rGInstagram: https://bit.ly/2MjShh0Facebook: https://bit.ly/2z41u4i Business Inquiries:info@erikamarcoux.com ➤ABOUTYOUR TRUTH REVEALED video podcast.
Chris Smith from the Naked Scientists takes on YOUR questions. Do dogs recognise themselves in the mirror? Why is the sky blue? Why doesn't mitochondrial DNA recombine like other DNA, and does it run into problems with natural selection? Why did my tracksuit give me an electric shock? Would planting trees prevent climate change? Plus, Chris reflects on almost twelve years of questions on Talk Radio 702... Like this podcast? Please help us by supporting the Naked Scientists
Chris Smith from the Naked Scientists takes on YOUR questions. Do dogs recognise themselves in the mirror? Why is the sky blue? Why doesn't mitochondrial DNA recombine like other DNA, and does it run into problems with natural selection? Why did my tracksuit give me an electric shock? Would planting trees prevent climate change? Plus, Chris reflects on almost twelve years of questions on Talk Radio 702... Like this podcast? Please help us by supporting the Naked Scientists
Cindy S.H.: Hi. Welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal Circulation Research. I'm your host, Cindy St. Hilaire, and my goal is to bring you highlights of articles published in the Circ Research Journal as well as have in-depth conversations with senior scientists and the junior trainees who have led the most exciting discoveries in our current issues. Today is our premier episode, so I want to take some time to introduce myself, give you a little bit of background about the history of the journal, and then have a conversation with our new editor in chief, Dr. Jane Freedman, and my social media editor partner in crime, Dr. Milka Koupenova. Cindy S.H.: First, a little bit about me. I'm an assistant professor of medicine and bioengineering at the University of Pittsburgh. My lab is part of the division of cardiology and we're also a member of the Pittsburgh Heart, Lung and Blood Vascular Medicine Institute. I'm still a relatively new PI. I'm still learning as I go. One of the strengths of being a new PI in the current time is the amazing network we have through social media, whether it's through listening to podcasts or through Twitter or through select groups like one of my favorites, New PI Slack. Really one of my personal goals of starting this podcast for Circ Research is to have a career development angle. Because career development is so fresh in my mind and it's really something I want to incorporate into this podcast, we're hoping we can reach out to more junior trainees through these mediums. Really that's the impetus for Dr. Freedman wanting to have specific social media editors at the Circulation Research Journal. Cindy S.H.: I'm very honored to be the first host of this podcast and I'm very excited for this opportunity. As a team, Milka and I hope to expose the larger community to not only the most current and exciting discoveries in cardiovascular research but also a behind-the-scenes look of what it takes to get high-impact research done and published and planned and funded, and also talk about some of the maybe the non-bench aspects of this job, the networking, the behind-the-scenes look that really you learn on the fly as you go. Hopefully we can expose more people to these on-the-fly things in a slightly more rigorous manner. Cindy S.H.: Before I go into the articles summarized in this week's podcast, I want to give a very big thank you to Ruth Williams. Ruth is the person who writes the content of the In This Issue which is featured in every issue of the journal Circulation Research, and that content is extremely helpful in deciding which articles we're going to focus on in this podcast and also for helping me form the conversations and discussions. Thank you, Ruth, for all your hard work. Cindy S.H.: Now I'm going to highlight three articles that were featured in the June 21st issue of Circulation Research. The first is entitled Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality: A 30-Year Prospective Cohort Analysis. The first author is Jiaqi Huang and the corresponding author is Demetrius Albanes , who are both at the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, which is at the NIH in Bethesda, Maryland. Alpha-tocopherol is the more formal name for vitamin E, and vitamin E is an essential fat-soluble vitamin. By essential, that means that while your body absolutely needs it, it does not produce it itself. Therefore we need to consume products containing vitamin E. We do that by eating vegetable oils, nuts, seeds, whole grains and certain fruits and vegetables. Previously, population-based studies have shown inconsistent associations between circulating vitamin E and risk of overall death or death due to specific diseases such as cancer and cardiovascular disease. Cindy S.H.: To look more closely at cause-specific mortality, Huang and colleagues studied a cohort of close to 30,000 Finnish men, which is a huge study. Added to that, these men were in their 50s and 60s at the start of the study and then continued for the next 30 years of their life to be in this study. It's frankly an amazing achievement to keep that many individuals enrolled. From approximately 24,000 deaths, so about 80% of the original cohort, the authors adjusted for factors such as age and confounding things like smoking. They found that vitamin E levels were inversely associated with the risk of death from a variety of causes. What that means is that higher levels of vitamin E associated with lower risk of death. All of those causes of death that they found were cardiovascular disease, heart disease, stroke, cancer, and respiratory disease. This large prospective cohort analysis provides very strong evidence that higher vitamin E levels means greater protection. Cindy S.H.: It's really interesting to note though that this data did not seem to associate with a reduced risk of death by diabetes or, for that matter, injury and accidents, which I guess kind of makes sense. The authors say these results indicate that vitamin E may influence longevity, but they also highlight the need for further studies, specifically in more ethnically diverse populations and of course in women, because we all know a major limiting factor of a majority of cardiovascular studies is the fact that often there are just not enough women in these studies. But really that's a push now to include not only women but more ethnically and geographically diverse populations. Cindy S.H.: The second article I want to highlight is titled Mitochondria Are a subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells . The first authors are Florian Puhm and Taras Afonyushkin , and the senior author is Christopher Binder. All three are in the Department of Laboratory Medicine, the Medical University of Vienna, in Vienna, Austria. This group is also part of the Research Center of Molecular Medicine of the Austrian Academy of Sciences. Cindy S.H.: I want to talk about this paper because I found that title extremely provocative. Extracellular vesicles or microvesicles are small particles that can be released from cells. These particles can act as cell-cell communicators. They can hold a variety of substances such as proteins and micro RNAs and minerals and all sorts of things that are derived from inside the cell. The matrix vesicle is then budded off. Matrix vesicles released from monocytes after bacterial LPS stimulation, so a stimulus that induces an inflammatory response, these matrix vesicles have been shown to contain mitochondrial proteins. Mitochondrial DNA-containing matrix vesicles have been reported in the mouse model of inflammation. From this premise, from these prior studies, Dr. Puhm and colleagues hypothesized that the mitochondrial content of matrix vesicles might actively contribute to pro-inflammatory effects. Cindy S.H.: What they then did was show that monocytic cells release free mitochondria and also matrix vesicles that contain mitochondria within them. These free and matrix vesicle-encapsulated mitochondria were shown to drive enothelial cells to induce inflammatory cytokines such as TNF-alpha and interferon. These circulating matrix vesicles were collected also in human volunteers that were injected with this same inflammatory substance, LPS. These circulating matrix vesicles isolated from humans also induced endothelial cell cytokine production. Very interestingly, inhibition of the mitochondrial activity drastically reduced the pro-inflammatory capacity of these matrix vesicles. Cindy S.H.: Together, this result suggests that the released mitochondria, whether it's free or whether it's encapsulated in a matrix vesicle, may be a key player in certain inflammatory diseases. This study shows that in addition to their central role in cellular metabolism, mitochondria, whether encapsulated or free, can actively participate in an inflammatory response in a cell other than the cell it was native in, which is just intriguing to think about. This work provides new insight to the contribution of mitochondria to the content and biological activity of extracellular vesicles. It also might suggest that perhaps targeting mitochondria and their release may represent a novel point for therapeutic intervention in inflammatory pathologies. Cindy S.H.: The last article I want to highlight is titled Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation . The first author is Bijun Chen and the senior author is Nikolaos Frangogiannis . When tissues are injured, there is localized increase in the cytokine TGF-beta. However, depending on conditions, this TGF-beta can function to stimulate macrophages to adopt either pro-inflammatory or anti-inflammatory phenotypes. To complicate matters more, the signaling pathway for both the pro- and anti-inflammatory phenotypes involves activation of the intracellular signaling protein Smad3. Inflammation, whether too much or too little, can influence the outcome of injuries, including injuries such as myocardial infarctions. An infarction, for those of you unfamiliar with the term, is a localized area of dead tissue and that results from a lack of blood supply. In this case, an infarction, a myocardial infarction, is essentially a heart attack that stops blood flow through the coronaries and causes death in the cardiac tissue and cells. Cindy S.H.: The authors hypothesized that in the infarcted myocardium, activation of TGF-beta and Smad signaling and macrophages may regulate repair and remodeling. They had a very specific question about a very specific cell type in the context of the whole heart. To address the role of Smad3, they utilized mice that were engineered to lack Smad3 in the myeloid lineage which produces macrophage cells. They found that these mice with myeloid cell-specific deletion of Smad3 had reduced survival compared to control mice. Additionally, the hearts from the animals with the myeloid cell-specific deletion of Smad3 exhibited increased adverse remodeling and greater impairment of function. That's a really interesting finding. The heart tissue itself was the same. All that was different were the cells of the myeloid lineage. Then to dig after what cells were mediating this effect, the investigators moved on to in vitro studies. They found that Smad3-lacking cells themselves showed reduced phagocytic activity, sustained expression of pro-inflammatory genes, and reduced production of anti-inflammatory mediators when compared with control macrophages. Cindy S.H.: In summary, these results suggest Smad3 is necessary for macrophages in the area of the infarction to transition to an anti-inflammatory phagocytic phenotype that protects against excess remodeling. However, we cannot go after global inhibition of Smad3 as a potential therapy post myocardial infarction, and that's because inhibition of Smad3 in cardiomyocytes is actually protective against the infarction. Inhibition in a macrophage is bad, but inhibition in a cardiomyocyte is good. Any potential Smad3-modifying therapies really needs to be designed to be cell type-specific and be able to be deployed to activate that cell type. Cindy S.H.: In addition to science, I love history. I thought I would take this opportunity of the first podcast to share with you a little bit of history about the Journal of Circulation Research. Circulation Research is now in its 66th year, but its origins can be traced to 1944. That was when the AHA established a council that was attempting to organize its research arm and its professional program arms. The AHA journal Circulation was already in existence, but in 1951 the executive committee decided to launch a basic research supplement, and it was called just that: Circulation Basic Research Supplement. But a few years later, Circulation Research was to be its own publication because of the interest and the excitement around the basic research supplements. The quote that I'm going to read is from that first executive committee meeting and there they wanted Circulation Research to be the authoritative new journal for investigators of basic sciences as they apply to the heart and circulation. Cindy S.H.: It's a fun little subgroup that they list after that. They list in anatomy, biology, biochemistry, morphology, which I just think is so neat to think about, pathology, physics, pharmacology, and others. It's interesting to think about what that would be today if we were now finding this journal. Biochemistry, genetics, molecular biology. It's fun to think about how much science has changed since they began this journal. Really the broader goal was to integrate and disseminate new knowledge. Leading that was Dr. Carl Wiggers, who was the first editor in chief of Circ Research. At the time, he was the head of physiology at Western Reserve University, and he's often referred to as the dean of physiology, as his research really provided much of the fundamental knowledge regarding the pressures in the heart and the vessels of the body and how they interact. Cindy S.H.: I actually went back and looked at some of the first titles in Volume One, Issue One, of Circ Research. It's really kind of neat. Some of them could be completely relevant today. I'm just going to read a few. Nucleotide Metabolism and Cardiac Activity, Fundamental Differences in the Reactivity of Blood Vessels in Skin Compared to Those in the Muscle. That was at the VRIC the other day. Haemodynamic Studies of Tricuspid Stenosis of Rheumatic Origin. Reading these for the first time I actually got chills because my two themes of my lab are both in that first Volume One, Issue One, of that journal. I study the extracellular nucleotide aCD73 and its impact on vascular homeostasis. I also study calcific aortic valve disease and are hugely curious about the role of inflammation and things like rheumatic heart disease in the progression of the disease. It's amazing how much science has changed, but yet how so much has stayed the same. Cindy S.H.: Dr. Wiggers wrote a few gems, a few quotes in his biography that I want to share with you. I find them inspiring and also humbling. The first is, "Research is a gamble in which the laws of chance favor the loser. The loser must remain a good sport," which I think is perfect to think about in science. I really wish I had read that after my first RO1 was triaged. The next two are more about the science writing and I think they're great not only for when we're thinking about papers but also grants. The first is, "Readers are greatly influenced in their judgment of a research project by literary style. A poor presentation can easily damage the best investigation," which is so true. No matter how good your science is, if you can't communicate it, it doesn't matter. And lastly, "A good paper, like a good glass of beer, should be neither largely foam nor flat. It should have just the right amount of head of foam to make it palatable." Cindy S.H.: With these nuggets of wisdom, we're now going to talk with Drs. Jane Freedman, who's now the editor in chief of Circ Research, and Dr. Milka Koupenova, who is the social media editor. Before I really introduce Jane, I want to recognize all of the former editors in chief of Circ Research, Dr. Carl Wiggers, Dr. Carl Schmidt, Dr. Eugene Landis, Dr. Julius Comroe, Dr. Robert Berne, Dr. Brian Hoffman, Dr. Francis Abboud, Dr. Harry Fozzard, Dr. Stephen Vatner, Dr. Eduardo Marbán, Dr. Roberto Bolli, and now Dr. Jane Freedman. Welcome, Jane. Thank you so much for this opportunity and congratulations on your new position. Dr. Freedman: Thank you very much. Cindy S.H.: I was wondering if you could just introduce yourself to the listeners and give us a little bit about your background. Dr. Freedman: Sure. I am the Budnitz Professor of Medicine at the University of Massachusetts, and I originally became interested in a scientific career while attending Yale University where I was both an architecture and geology major. Cindy S.H.: Interesting. Dr. Freedman: Yes, very interesting. Then, not exactly knowing what I wanted to do, I worked for a year as a research assistant for my later-to-be mentor Dr. Joe Loscalzo at Brigham and Women's Hospital. There one day he sent me up to the intensive care unit and said we need to get a tube of blood from someone who was in the throes of having a myocardial infarction. Really at that point I became hooked. Why was that person having a heart attack, and using their blood how could I figure out whether they would live, die, do well, not do well, or yield new things that might help us cure or diagnose people with heart attacks later on? After that. I went to Tufts Medical School. I did my residency and cardiology fellowship at Brigham and Women's Hospital and the Massachusetts General Hospital. After working at several different places, I have wound up at the University of Massachusetts where I am in the Division of Cardiology and where my laboratory currently resides. Cindy S.H.: Excellent. As the new editor in chief, what do you see as your vision for the journal? Dr. Freedman: I'm in a very fortunate position to be taking over a wonderful journal from an incredibly dedicated group of editors and associate editors and other supportive editors. Scientific pursuits and reporting and publications are really evolving at a rapid clip, so we hope to have several things happen over the next few years to survive and thrive. The first thing is we hope to define and expand Circulation Research's scientific identity. We want to extend its already outstanding portfolio of science that really demonstrates how elegant basic and translational mechanisms and pathways are part of a greater web of cardiovascular disease and stroke. This will include an increasingly diverse group of basic and translational sciences and they'll touch on both fundamental studies as well as how they translate to human disease. We also want to continue to pursue the excellence that Circulation Research already epitomizes and we want to extend its brand both to an increasingly diverse group of members, both nationally and internationally. Dr. Freedman: Circulation Research already has really wonderful publication metrics such as turnaround time, time to review, and we hope to maintain that so as to be a journal of choice for an increasingly growing number of investigators. We would also very much like to have greater interface with the American Heart Association. A lot of the research on our pages is funded by the American Heart Association, and the majority of science that the American Heart Association currently funds is basic cardiovascular science. We hope to have greater interface and help our users of the journal understand what the American Heart Association can do for them and for their scientific pursuits. Dr. Freedman: Last and very importantly, we really want to attract early and mid-career investigators to the journal. We already have some really nice programs that the previous editorship has started, such as Meet The First Author, but we would also like to be a site for education of how you can review papers, have a junior editor program and other types of programs that will help early and mid-career investigators in their future. One of the ways we're going to be doing that is to have enhanced social media programs. Cindy S.H.: Great. I really like that idea of having the junior editors because I think the best learning experience I had about how to write a grant did not happen until I actually served on a study section, because it was there you actually can understand all of those comments you got on your first grant that was triaged and why they were said. I think that is a key and really important aspect. Dr. Freedman: That's a perfect analogy because you want to remove the black box that people think is happening when they send their manuscripts in. There's so many reasons why manuscripts succeed and don't succeed, and we really do want to be as transparent as possible and we do want to educate investigators as much as possible about the process. Cindy S.H.: Actually, could you maybe tell us a little bit about that process? I made all my figures, I formatted my paper according to the instructions, I hit submit. Black box. What happens? What's the next step? Dr. Freedman: What's the next step? Cindy S.H.: What do you do? What does an editor in chief actually do? Dr. Freedman: I do have to say that none of this would happen, especially in the incredibly quick turnaround time, if we didn't have amazing support and help in our office that happens to be in Baltimore. The people there are just incredible. They make sure that papers move through. It's really 24/7. Our group has not been at it for very long, but I know Dr. Bolli's group as well as our group, people are handling manuscripts as fast as they really come in. We see the manuscript, they get quality checked. We try not to be too onerous with the first steps. Then typically they go to one of the associate or deputy editors who will handle them to send out for review. Cindy S.H.: Is that based on keywords or the title or how is that decided? Dr. Freedman: Sometimes it's based on keywords, so careful with your keywords. A lot of times, because each of the associate editors has an area of expertise that hopefully covers what your science is interested in, they will know experts in the field. We very heavily rely on our editorial board. We have an amazing editorial board at Circulation Research, and amazing contributions from the BCBS council. These individuals have over the years and currently provided just tireless and unsung, devoted help to making the journal run smoothly. It's a pretty quick turnaround time. Then the decision made based on the reviews of the article. Occasionally articles come in and they're not suitable for the journal because they're not what we perceive as what our readers would be interested in. Sometimes those articles don't go up for review. We don't want to keep them caught up, so we send them back right away. Dr. Freedman: When the articles come back in with the reviews, we're going to be discussing them at a weekly meeting. Other viewpoints will weigh in, and then we make a decision whether it's an accept, whether it's a revise, whether it needs a lot more science. That's called a de novo. Sometimes we think it's more suitable for one of the other 11 American Heart Journals and we might suggest that you consider sending it to that journal and we consult with that journal's editor. Cindy S.H.: Interesting. All that happens with about 14 days. Dr. Freedman: That's supposed to happen with 14 days. Cindy S.H.: It does pretty regularly based on the stats. That's amazing. One of the initiatives you mentioned was really the role of social media. Now I would like to introduce Dr Milka Koupenova, who is the co social media editor alongside me. Before I let Milka talk, I really have to be honest and say that my graduate school days were some of the best of my life. It was in part because Milka I were both in the same lab. We overlapped by a couple of years under the amazing mentorship of Dr. Katya Ravid. Every time we get together, all we'd talk about was how can we be like Katya? Maybe someday we'll actually have a podcast where we can get Katya in here and actually record all her nuggets of wisdom. Dr. Koupenova: I think the same thing about Katya. Cindy S.H.: How can it be more like Katya? But for now, Milka, welcome. Thank you. If you could just introduce yourself and give us a little bit about your background. Dr. Koupenova: Hi, everybody. My name is Milka Koupenova. I am an assistant professor at University of Massachusetts Medical School. Briefly about me, as Cindy mentioned, I did my PhD at Boston University and I studied at that time metabolism in atherosclerosis. Then I had this great opportunity to join this lab in thrombosis that studied these little cell fragments called platelets, which I knew something but not that much about. I joined Dr. Freedman lab as a postdoctoral fellow, and actually my interest evolved to be very much in platelet immunobiology and how platelets may contribute to thrombotic disease during viral infections. Luckily for me, I had two angels that I wanted to be. One of them was Katya Ravid, as you mentioned, and the other one was Dr. Freedman. Both set up a great example of scientists and how to do science in life. Cindy S.H.: Wonderful. Excellent. Thank you. I won't lie. I don't know if you feel this way. I definitely feel a little nervous about being a social media editor. I'm talking in a room to a box with a microphone on me and I don't know who's going to be listening. That's also exciting for me too. I get to disseminate all this cool knowledge and share our basic research with this huge audience. What are you most nervous about and excited about? Dr. Koupenova: You're doing the podcast, so I don't have to worry about that, that that particular part. I am quite excited actually about everything that's going to surround popularizing the science at Circulation Research. I think in the time that we live in and when social media is a huge part of our life, we definitely need to engage the community, scientific or lay, and communicate our ideas. I'm super excited about the creative part behind how we are going to achieve this via various social medias. Cindy S.H.: Can you talk about the platforms that you plan on using? Dr. Koupenova: We currently are using Twitter and Facebook. Please follow us on Twitter and Facebook. And we are going to launch Instagram. Find us, follow us, engage us. That will be great. You can always send us messages and like us, retweet whatever you decide. Cindy S.H.: Give podcast feedback on Twitter. Nice comments only. Dr. Koupenova: We'd like to hear your comments and we'd like to hear what you envision in certain cases when it comes to your Circulation Research, because this is your journal as much as it is ours. We're here for you. In addition to popularize and advertise the wonderful science that we're publishing in Circ Research, we want you to be engaged. We want you to be able to advertise in your own work and to think of it as something that you own and something you need to communicate to the rest of the world. That is one of the things that we want to do. Dr. Koupenova: Finally I'm going to echo on what Dr. Freedman said, is we want to attract truly early career and young investigators and help them be involved, help them own their science and help them communicate their ideas. That's pretty much what our social media platform is and we are going to evolve with you. That is perhaps one of the challenges. Cindy S.H.: I think one of the most interesting aspects, at least in academia as I see it, is really the role of self-promotion. It's something you're never taught and it's something that you don't really appreciate until you go to that conference. I remember my first conference as a new PI, I was standing there and I'm just like, "Okay, these are all other PIs. How are they all in groups? How does everybody know each other? Why are they all friends already?" It takes a lot of guts and you have to inject yourself. "Hi. I'm Cindy St. Hilaire and I'm new. Please be my friend," essentially, essentially. But it's important and I really liked the fact that when your journal is published you have that little button, share on Twitter, share on Facebook. I think that's really important. It helps you practice that self-promotion and can help really allow you to embrace your extrovert when you know how to. Dr. Koupenova: That's exactly what I was going to point out. Scientists or physician scientists, or physician scientists perhaps are a bit better. But as scientists we're very much introverted. But social media gives you a platform that it's not cheesy to popularize and communicate. Then you see those people on conferences and then you have your little group without- Cindy S.H.: It's amazing how many Twitter friends I have. "Oh, I met you on Twitter. It's so nice to meet you in real life." Dr. Koupenova: It's a new generation. We at Circ Research want to evolve with it. Is that correct, Dr. Freedman? Dr. Freedman: That is correct. Thank you very much. Cindy S.H.: It's exciting times. I guess maybe this is a question for all of us to talk about, but how do you think we can, number one, attract people to science, attract diverse people to science, and then really keep them in science and how do you think we can use Circ Research and also the social media aspects of Circ Research to do that? Dr. Freedman: I think, first of all, people have to see themselves in the journal. The journal, I think the first point I talked about, about being inclusive, inclusive types of people, way people consume science, types of science. We really want people to feel like Circ Research isn't just a journal that puts out scientific papers, but is a forum. It's a forum for them to exchange ideas and it's a forum for them to understand better about their scientific careers. Cindy S.H.: Great. Thank you. This has been an amazing first podcast. I'm so happy to share it with the two of you and I'm super excited for this opportunity. Again, Jane, I want to congratulate you on your new position as editor in chief and I can't help but mention as the first female editor in chief. That's a wonderful, wonderful thing. Cindy S.H.: You can find us on Twitter. The handle is @CircRes, at C-I-R-C-R-E-S. We're also on Instagram using the same name, C-I-R-C-R-E-S. We hope to hear from you there. Cindy S.H.: Thank you for listening. I'm your host, Cindy St. Hilaire, and this is Discover CircRes, your source for the most up-to-date and exciting discoveries in basic cardiovascular research.
The first episode looks at Mitochondrial DNA research into mental disorders, and how it has helped scientists understand the origin and biological ancestry of the Danish population. Principal Investigator, and Cheif Physician at SSI, Michael Christiansen tells the story. The Danish National Biobank is a treasury of science for international health research. It contains 10 million biosamples across an array of diagnostic categories, as well as the Danish Biobank Register that links over 25 million biosamples in Danish biobanks to vast amounts of register information. This podcast will give an insight into some of the amazing research done through the Danish National Biobank and hopefully inspire researchers to utilize this potential in the future.
Maria do Carmo Fonseca é presidente do Instituto de Medicina Molecular e professora catedrática na Faculdade de Medicina da Universidade de Lisboa, onde lidera um laboratório com o seu nome, que desenvolve trabalho de investigação na área da genética. Em 2010, viu o seu trabalho reconhecido com a atribuição do Prémio Pessoa. Torne-se mecenas do podcast, a partir de 2€, através do Patreon! Obrigado aos mecenas do podcast: Gustavo Pimenta João Vítor Baltazar; Salvador Cunha; Ana Mateus; Nelson Teodoro; Paulo Ferreira; Duarte Dória; Falcão Milenar Abílio Silva; Tiago Neves Paixão; João Pinto; Daniel Correia; João Saro; Rita Mateus Vasco Sá Pinto; David; Pedro Vaz; Luís Ferreira; André Gamito, Rui Baldaia; Henrique Pedro; Manuel Lagarto; Rui Carrilho; Luis Quelhas Valente; Tomás Costa; Tiago Pires; Mafalda Pratas; Filipe Ribeiro; Renato Vasconcelos; João Salvado; Joana Martins; Luís Marques; João Bastos; João Raimundo; Francisco Arantes; ; Francisco dos Santos Ligações: Dragão de Komodo consegue alternar entre reprodução sexuada e assexuada Mitochondrial DNA can be inherited from fathers, not just mothers Primeiro medicamento de interferência no RNA Less than 10% of human DNA has functional role, claim scientists Médico chinês CRISPR Use Creates Malaria-Resistant Mosquitoes Livro recomendado: ‘Homo Deus - História Breve do Amanhã, de Yuval Noah Harari’ Bio: Maria do Carmo Fonseca é presidente do Instituto de Medicina Molecular e professora na Faculdade de Medicina de Lisboa, onde lidera um laboratório com o seu nome – o Maria do Carmo Fonseca Lab – que desenvolve trabalho de investigação precisamente na área da edição genética. Licenciada em Medicina pela Faculdade de Medicina da Universidade de Lisboa e doutorada em Biologia Celular na mesma instituição em 1988. Vencedora da 24.ª edição do Prémio Pessoa, em 2010.
"Light Speed" Episode 127 with Thaddeus Owen :30 - Fire and Ice Retreat 2:00 - Light Therapy/Quantum Physics 3:00 - Mitochondrial DNA 4:00 - How Latitude and Longitude on our planet effects your DNA 5:25 - Steam Room vs. Sauna 5:50 - Heat Shock Protein 6:45 - Tap Water 8:30 - Skin is your Largest Organ 10:25 - Light Studies 11:00 - How Being Outside Cures Disease 14:00 - Nuclear DNA vs. Mitochondrial DNA 17:35 - Skin Issues 18:05 - Solar Callusing/Circadian Biology/Sun Gazing 25:00 - How the Sun Turns into Neurochemicals 28:35 - Wim Hof 31:30 - How Attention Brings the Most Out of You/Flow State 36:05 - How Flow State Helps you Learn 39:00 - Microdosing 42:10 - Mushroom Kingdom 48:20 - 5G Technology Thank you to Primal Hacker and Soltara Retreat Center for sponsoring this episode.
Claire find out that some humans have mitochondria from their father as well as their mother, Stu Listens to the music of the planets, and Chris finds out the science behind the sensation of having an answer on the tip of your tongue
Practical advice on helping students manage test anxiety. Updates in mitochondrial inheritance and cardiac stem cells, plus a way to access journal articles that are behind a paywall. Extended bonus episode. 00:53 | It's a BONUS episode! 01:15 | Mitochondrial inheritance 04:28 | Cardiac stem cells 06:48 | Sponsored by HAPS 07:20 | Help getting journal articles 11:18 | Sponsored by AAA11:31 | Featured: Helping students with test anxiety If you cannot see or activate the audio player click here. Questions & Feedback: 1-833-LION-DEN (1-833-546-6336) Follow The A&P Professor on Twitter, Facebook, Blogger, Nuzzel, Tumblr, or Instagram! I'm trying to stay as calm as possible and focus one day at a time, but when reality sets in, I feel everything: anxiety, excitement, nerves, pressure and joy. (Shawn Johnson) This is a BONUS episode—which means it's a long one! 1 |Mitochondrial inheritance 3 minutes New research shows that in some cases, paternal mtDNA may be passed along to offspring in a pattern that resembles autosomal dominant inheritance. Biparental Inheritance of Mitochondrial DNA in Humans (research article) my-ap.us/2PeptDl 2 | Cardiac stem cells 2 minutes Do cardiac stem cells exist? We thought so. But maybe not. Dozens of Retractions Requested for Heart Stem Cell Studies (news item) my-ap.us/2PanzUx Adult Cardiac Stem Cells Don't Exist: Study (news item) my-ap.us/2Pdvdxg More Doubt Cast Over Cardiac Stem Cells (older news item) my-ap.us/2Pd9a9O 3 | Sponsored by HAPS 0.5 minutes The Human Anatomy & Physiology Society (HAPS) is a sponsor of this podcast. Did you know there's a reduced "early bird" registration rate for the annual HAPS confercnce in Portland OR next May? Check it out. You can help appreciate their support by clicking the link below and checking out the many resources and benefits found there. Anatomy & Physiology Society | theAPprofessor.org/haps 4 | Help getting journal articles 4 minutes Follow one of my links (or some other hyperlink) and it takes you to journal article that's behind a paywall? Kevin explains a legal, ethical way to access the full article with no costs to you. You'll have to listen to hear this super secret trick! 5 | Sponsored by AAA 0.5 minute The searchable transcript for this episode, as well as the captioned audiogram of this episode, are sponsored by The American Association of Anatomists (AAA) at anatomy.org Searchable transcript my-ap.us/TAPP32 Captioned audiogram https://youtu.be/JU_l76JGwVw 6 | Helping students with text anxiety 45 minutes Kevin's Theory of Test Anxiety states that we are ALL subject to test anxiety. Perhaps occasionally. Perhaps often. In any case, it can affect our ability to retrieve and apply the information we've practiced and thereby affect our performance—and score—on a test or exam. Sometimes significantly. What, if anything, can be done to avoid text anxiety or manage it once it strikes? What can teachers do? What can students do? Well, here's a place to start! Here are some links you can share with your students: 9 Proven Tricks for Reducing Test Anxiety my-ap.us/9anxietytricks Take a Nap Before Your Next A&P Test my-ap.us/napbeforetest Don't forget to breathe! my-ap.us/dontforget2breathe Coloring Books Are Powerful Study Tools (And They Help Manage Stress) my-ap.us/APcoloringbooks Get Your Head in the Game - 5 Tips for Success in Learning my-ap.us/APgetheadingame If the hyperlinks here are not active, go to TAPPradio.org to find the episode page. More details at the episode page. Transcript available at the script page. Listen to any episode on your Alexa device. Join The A&P Professor social network: Blog Twitter @theAPprofessor Facebook theAPprofessor Instagram theAPprofessor YouTube Amazon referrals help defray podcasting expenses. Transcript and captions for this episode are supported by the American Association of Anatomists. The Human Anatomy & Physiology Society also provides support for this podcast.(Clicking on sponsor links helps let them know you appreciate their support of this podcast!)
In this episode, Nav Chandel, a professor of medicine and cell and molecular biology at Northwestern University, discusses the role of mitochondria and metabolism in health and disease. Nav also provides insights into the mitochondria as signaling organelles, antioxidants, and metformin’s multifaceted effects on human health, among many topics related to well-being. We discuss: What got Nav interested in mitochondria [5:00]; Reactive oxygen species (ROS) [16:00]; Antioxidants: helpful or harmful? [20:00]; Mitochondria as signaling organelles [22:00]; Hydrogen peroxide (H2O2) [25:00]; Mitochondrial DNA [28:00]; Mitochondria and aging [45:00]; Metformin [52:45]; Metformin and the gut microbiome [54:00]; Metformin as complex I inhibitor and the importance of the NADH/NAD ratio [1:01:00]; Anticancer benefits of metformin [1:07:45]; Mitochondrial function is necessary for tumorigenesis [1:15:00]; Are somatic mutations the result of mitochondrial dysfunction? [1:31:30]; Vitamins and antioxidants [1:37:00]; Targeting inflammation in disease [1:43:00]; NAD precursors [1:45:45]; MitoQ [1:52:00]; Metabolite toxicity [1:56:30]; Cortisol and healthy aging [2:02:00]; Nav turns the tables and asks Peter how he deals with the “So what should I eat?” question during social encounters [2:09:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.
→ Join us on Patreon ← Dr. Peter Attia, MD is the founder of Attia Medical, PC, a medical practice that focuses on increasing healthspan by minimizing the risk of chronic disease and preserving quality of life. Peter trained for five years at Johns Hopkins in general surgery and then spent two years at NIH as a surgical oncology fellow. He has since been mentored by some of the most experienced and innovative physicians and scientists in the US and Canada. On this podcast Dr. Tommy Wood, MD talks with Peter about the critical components of lifespan and healthspan, including the factors he has identified as most important. They also discuss the controversial role of statin medication and take a close look at the necessity and sufficiency of risk factors for atherosclerosis. If you want to learn more about Peter’s work, he has a blog, a podcast and an active social media presence. Here’s the outline of this interview with Peter Attia: [00:00:35] Mellow Johnny’s Bike Shop. [00:04:01] Eddy Merckx. [00:04:16] Healthspan. Video: Peter Attia - Reverse engineered approach to human longevity. [00:05:23] Components of healthspan: cognitive, physical, emotional. [00:07:21] Lewis Hamilton; Ayrton Senna. [00:08:35] Reverse engineering healthspan. [00:11:34] Strength, power, aerobic and anaerobic fitness, flexibility. [00:14:57] Injuries affecting healthspan. [00:16:27] Exercise dosing studies: Marshall, Simon J., et al. "Translating physical activity recommendations into a pedometer-based step goal: 3000 steps in 30 minutes." American journal of preventive medicine 36.5 (2009): 410-415; Merghani, Ahmed, Aneil Malhotra, and Sanjay Sharma. "The U-shaped relationship between exercise and cardiac morbidity." Trends in cardiovascular medicine 26.3 (2016): 232-240. [00:17:26] Atrial fibrillation; mitochondrial injury. [00:18:39] Study: Nakayama, Hiroyuki, and Kinya Otsu. "Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases." Biochemical Journal 475.5 (2018): 839-852. [00:19:28] Functional threshold power (FTP). [00:23:58] Podcast: The High-Performance Athlete with Drs Tommy Wood and Andy Galpin. [00:23:59] Twin study: Bathgate, Katherine E., et al. "Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits." European journal of applied physiology 118.10 (2018): 2097-2110. [00:24:50] The emotional component of healthspan. [00:24:56] The Drive Podcast: Paul Conti, M.D.: trauma, suicide, community, and self-compassion. [00:25:59] Dave Feldman; Podcast: How to Drop Your Cholesterol. [00:26:40] Sam Harris: Meditation. [00:29:30] Video: Commencement speech by David Foster Wallace from 2005 at Kenyon College, This is Water. [00:30:45] Vulnerability as a practitioner. [00:33:46] Time-restricted feeding. [00:34:23] Continuous glucose monitoring (CGM); Oura ring. [00:35:38] Factors contributing to longevity: deprivation of calories and rapamycin. [00:37:54] Benefits of fasting. [00:41:04] Free T3:Reverse T3 ratios during fasting. [00:42:50] Study: Finkelstein, Joel S., et al. "Gonadal steroids and body composition, strength, and sexual function in men." New England Journal of Medicine 369.11 (2013): 1011-1022. [00:43:30] Robert Lustig. [00:45:07] Multi-Ethnic Study of Atherosclerosis (MESA). [00:46:09] Statins; side effects. [00:48:36] Lipoprotein(a) - Lp(a). [00:49:19] Coronary Artery Calcium (CAC) scan. [00:54:03] The Drive podcasts: Dave Feldman, Ron Krauss, Tom Dayspring: (parts 1, 2, 3, 4, 5). [00:54:32] Risk factors for atherosclerosis: necessity and sufficiency. [00:56:16] Lead study: Lanphear, Bruce P., et al. "Low-level lead exposure and mortality in US adults: a population-based cohort study." The Lancet Public Health 3.4 (2018): e177-e184. [00:59:03] LDL cholesterol; ApoB. [01:01:15] Familial Hypercholesterolemia (FH). [01:04:41] Hyper-responders. [01:06:25] Saturated fat/cholesterol study: Jones, P. J., A. H. Lichtenstein, and E. J. Schaefer. "Interaction of dietary fat saturation and cholesterol level on cholesterol synthesis measured using deuterium incorporation." Journal of lipid research 35.6 (1994): 1093-1101. [01:09:43] Feldman Protocol. [01:11:48] The Drive podcast; peterattiamd.com.
Join us on todays share for special discussion on Hereditary and Genetics with FleurBrun. Who is FleurBrun: FleurBrun is a Philanthropist Pantheist rooted from the French Antilles, reared in New York. I've had consistent paranormal experiences as well as contact from celestial and Galactic entities since youth. As a wholistic practitioner who's linked nutrition to behavior and spiritual body, who advocates for Hueman and animals rights. She is a here as a Stewart to Mother Gaia, incarnated as a Elemental, to assist in her monumental Ascension. The Divine Feminine Energies have begun to sweep over the planet in preparation for Aquarius RiZing 9th Gate. Her goal is to expose hidden agendas, as well as disclose the Psyop cover up of Melaninated/Carbon Galactic beings, that have been visiting us since the beginning of time. As many contactees step forward and share their experiences with Galactic/ inter dimensional / inner terrestrial beings, we can now put the pieces of the puzzle together to disclose the hidden truths that lie just beneath the surface. Welcome to the New Paradigm, The Age Of Aquarius, the Age of Femininity and the Return of the Womb-Man. Tune in tonight for a thought provocking discussion on HEREDITAY AND GENETICS! Tune in, call in, chat in, skype in and Lets talk!
Join host Greg Carlwood of The Higherside Chats podcast as he talks the Out of Australia theory, Dreamtime, and the Pleiades with guest, Steven Strong. Many alternative researchers, archaeologists and scholars of history have dedicated countless hours pouring over ancient sites and remains in hopes of piecing together humanity's hidden origins. And while the secrets of our past still stand shrouded in mystery, researchers like today's guest, Steven Strong, have spent decades peeling back the layers in an effort to reconstruct the damaged human psyche. And, thanks to his well-established relationships with the Original Elders of Australia and their willingness to share their sacred oral history, we now have a growing body of recently unearthed evidence to help bring the secret knowledge of mankind's making to the light. 5:55 In order to properly understand Strong's alternative perspective, one must first be familiar with the Out of Africa theory. Steven starts by clearly defining the evidence used in the Out of Africa theory, giving a bit of background on the key players involved, and walking through the holes in this now widely scrutinized paradigm. Strong also walks us through the various genetic traits such as Denisovan and Neanderthal, where they are found and what these links tell us about the differences between Original People and Africans. 14:42 After examining the holes in the Out of Africa theory, and touching upon the genetic differences found in the Original People of Australia, Greg and Steven discuss the cosmology and alternative oral history of the Elders, the healing process that began centuries ago, and the seeding of Pleiadian genes throughout the world. 23:42 Greg and Steven discuss the work of Michael Tellinger, our genetic disposition as a slave race, the various other beings that have influenced humanity, and how it connects to Strong's research. 33:00 Continuing with their discussion of anomalous site in Australia that have the potential to rewrite history, Greg and Steven discuss Lake George and Panaramitee, as well as the Kariong Glyphs and the perplexing pendant containing several unidentifiable metals. 41:20 Greg and Steven discuss the element of magic in the Original culture, their Shamanic practices, and the possibilities available when people reach their true spiritual potential. Become a Plus Member at www.TheHighersideChatsPlus.com/subscribe to hear a second hour of all THC episodes. This week's included: - information and stories about the magic rocks that Stephen has been tasked with being the custodian of - how the Australian Originals' stories about their animals, like the dingo and kangaroo -as well as the genetic data, might tie into the theme of otherworldly origins - Steven's plan to use what he's learned, along with the help of others and the magic rocks he has, to open a publicly available portal on a sacred island that translated to “Gateway to the Heavens” - the history of Australia's colonial takeover, how it differs from what happened with Columbus in America, and how it effected the people of Tasmania - why the Egyptians have more of a right to set up an embassy in Australia, than the British do. - how ancestral spirits of the land relate to Australian Originals', and why they didn't harm the invading British - how ancient largely unknown sites in Australia compare, and often dwarf the scale of, more famous sites around the planet - the struggle with the Australian government to keep them from bulldozing through an ancient 7 step pyramid to make way for a highway extension A few valuable resources from the interview: "Mitochondrial DNA and Human Evolution" (1987) by Rebecca Louise Cann, Mark Stoneking, and Allan Charles Wilson: https://embryo.asu.edu/pages/mitochondrial-dna-and-human-evolution-1987-rebecca-louise-cann-mark-stoneking-and-allan Denisovan: https://en.wikipedia.org/wiki/Denisovan
Extreme Genes - America's Family History and Genealogy Radio Show & Podcast
Host Scott Fisher opens the show with David Allen Lambert, Chief Genealogist of the New England Historic Genealogical Society and AmericanAncestors.org. David shares some great stories this week, including one about a family that found a funeral home had dressed the wrong corpse in their mother’s clothes, a man who found his father’s and uncle’s letters homes from World War II on eBay, and the story of a Saxon king whose remains may have been found under a tennis court! (Here we go again!) David’s spotlighted blogger this week is FamilySearch.org/blog/en which discusses, among many other things, how to get started in indexing old records. Next, Fisher is going DNA crazy this week, having shipped out three Y-chromosome DNA kits to close and distant relatives. He’s pondering using a mitochondrial test for one of his wife’s lines. “Not so fast!” says LegacyTree.com’s Paul Woodbury. The DNA specialist shares some important insight on when you should and when you shouldn’t attempt to connect ancestors through this female direct line DNA method. Then, Carrie Christos of Cincinnati, Ohio talks about her “Big Fat Greek genealogical experience.” She shares the challenges she faced, the serendipity that (as is often the case) kicked in, and the new relationships she has developed. Carrie will tell you how it all happened. Then, Tom Perry, the Preservation Authority from TMCPlace.com is geeked out over a remarkable time-lapse video he found. It will inspire you to learn how you can do the same. Tom also talks about some local digitizers that he feels will do a great job for you in several states. That’s all the week on Extreme Genes, America’s Family History Show!
CHI chats with Bert Smeets, Ph.D., Professor, Clinical Genomics, Mitochondrial Diseases, Maastricht University Medical Center. Dr. Smeets discusses the latest research and developments on diagnosing mtDNA disease using Next-Generation Sequencing, as well as his work in developing techniques to prevent mtDNA disease transmission and developing therapeutics for those affected by mtDNA disease. Dr. Smeets is one of our speakers for the Novel Diagnostic Approaches session at the Reproductive Genetic Diagnostics conference, 6-7 April, in Lisbon. For details, visit http://www.MolecularDXEurope.com/Reproductive-Genetic-DX
In the 1970s and 80s, an interesting academic dispute rose between two rival camps of scientists in the field of Paleoanthropology, the study of human evolution. The main question dealt with the theories of when and where the modern human, the Homo-Sapiens, appeared. The post Molecular Clock, Pt.1: Mitochondrial DNA | Curious Minds appeared first on Curious Minds Podcast.
Mitochondrial DNA is only inherited from your mother. Everyone alive on earth today can trace their lineage back to Mitochondrial Eve. We know this because we’ve all received our Mitochondrial DNA from her. It has been passed down generation by generation from mother to daughter.
Scientists discover a new process, in which mitochondrial DNA is exchanged between cells in the body
Scientists discover a new process, in which mitochondrial DNA is exchanged between cells in the body
Professor Lisa Matisoo-Smith talks about work on ancient DNA, and the light thrown on migration across East Polynesia.The Ozone presentations took place September 2013, in St David's theatre
Background: Myanmar is the largest country in mainland Southeast Asia with a population of 55 million people subdivided into more than 100 ethnic groups. Ruled by changing kingdoms and dynasties and lying on the trade route between India and China, Myanmar was influenced by numerous cultures. Since its independence from British occupation, tensions between the ruling Bamar and ethnic minorities increased. Results: Our aim was to search for genetic footprints of Myanmar's geographic, historic and sociocultural characteristics and to contribute to the picture of human colonization by describing and dating of new mitochondrial DNA (mtDNA) haplogroups. Therefore, we sequenced the mtDNA control region of 327 unrelated donors and the complete mitochondrial genome of 44 selected individuals according to highest quality standards. Conclusion: Phylogenetic analyses of the entire mtDNA genomes uncovered eight new haplogroups and three unclassified basal M-lineages. The multi-ethnic population and the complex history of Myanmar were reflected in its mtDNA heterogeneity. Population genetic analyses of Burmese control region sequences combined with population data from neighboring countries revealed that the Myanmar haplogroup distribution showed a typical Southeast Asian pattern, but also Northeast Asian and Indian influences. The population structure of the extraordinarily diverse Bamar differed from that of the Karen people who displayed signs of genetic isolation. Migration analyses indicated a considerable genetic exchange with an overall positive migration balance from Myanmar to neighboring countries. Age estimates of the newly described haplogroups point to the existence of evolutionary windows where climatic and cultural changes gave rise to mitochondrial haplogroup diversification in Asia.
We take a look at fear and hearing, legislation about embryos with three parents, a flashlight without batteries, spacecraft updates, viewer feedback, Curiosity news, and as always take a peek back into history and up in the sky this week.
We take a look at fear and hearing, legislation about embryos with three parents, a flashlight without batteries, spacecraft updates, viewer feedback, Curiosity news, and as always take a peek back into history and up in the sky this week.
"Tales of genes, gender and genealogy" Professor Vicky Cameron's Inaugural Professorial Lecture. Department of Medicine University of Otago, Christchurch.
"Tales of genes, gender and genealogy" Professor Vicky Cameron's Inaugural Professorial Lecture. Department of Medicine University of Otago, Christchurch.
"Tales of genes, gender and genealogy" Professor Vicky Cameron's Inaugural Professorial Lecture. Department of Medicine University of Otago, Christchurch.
"Tales of genes, gender and genealogy" Professor Vicky Cameron's Inaugural Professorial Lecture. Department of Medicine University of Otago, Christchurch.
Join MitoAction and Dr. Richard Boles from Children's Hospital Los Angeles and Courtagen Life Sciences, Inc to discuss the following questions: What is genomic sequencing and how does it change testing for mitochondrial disorders?, Is NextGen testing appropriate for all people with suspected mitochondrial disease?, How can DNA sequencing change information available about family inheritance of mitochondrial diseases?, Do advances in genomic sequencing impact treatment options for Mito patients?
Audio PodcastAired date: 3/21/2012 3:00:00 PM Eastern Time
Video Podcast (CC)Aired date: 3/21/2012 3:00:00 PM Eastern Time
Background: Deletions of the mitochondrial DNA (mtDNA) accumulate to high levels in dopaminergic neurons of the substantia nigra pars compacta (SNc) in normal aging and in patients with Parkinson's disease (PD). Human nigral neurons characteristically contain the pigment neuromelanin (NM), which is believed to alter the cellular redox-status. The impact of neuronal pigmentation, neurotransmitter status and brainstem location on the susceptibility to mtDNA damage remains unclear. We quantified mtDNA deletions (Delta mtDNA) in single pigmented and non-pigmented catecholaminergic, as well as non-catecholaminergic neurons of the human SNc, the ventral tegmental area (VTA) and the locus coeruleus (LC), using laser capture microdissection and single-cell real-time PCR. Results: In healthy aged individuals, Delta mtDNA levels were highest in pigmented catecholaminergic neurons (25.2 +/- 14.9%), followed by non-pigmented catecholamergic (18.0 +/- 11.2%) and non-catecholaminergic neurons (12.3 +/- 12.3%; p < 0.001). Within the catecholaminergic population, Delta mtDNA levels were highest in dopaminergic neurons of the SNc (33.9 +/- 21.6%) followed by dopaminergic neurons of the VTA (21.9 +/- 12.3%) and noradrenergic neurons of the LC (11.1 +/- 11.4%; p < 0.001). In PD patients, there was a trend to an elevated mutation load in surviving non-pigmented nigral neurons (27.13 +/- 16.73) compared to age-matched controls (19.15 +/- 11.06; p = 0.052), but levels where similar in pigmented nigral neurons of PD patients (41.62 +/- 19.61) and controls (41.80 +/- 22.62). Conclusions: Catecholaminergic brainstem neurons are differentially susceptible to mtDNA damage. Pigmented dopaminergic neurons of the SNc show the highest Delta mtDNA levels, possibly explaining the exceptional vulnerability of the nigro-striatal system in PD and aging. Although loss of pigmented noradrenergic LC neurons also is an early feature of PD pathology, mtDNA levels are not elevated in this nucleus in healthy controls. Thus, Delta mtDNA are neither an inevitable consequence of catecholamine metabolism nor a universal explanation for the regional vulnerability seen in PD.
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Because of the widespread phenomenon of patrilocality, it is hypothesized that Y-chromosome variants tend to be more localized geographically than those of mitochondrial DNA ( mtDNA). Empirical evidence confirmatory to this hypothesis was subsequently provided among certain patrilocal and matrilocal groups of Thailand, which conforms to the isolation by distance mode of gene diffusion. However, we expect intuitively that the patterns of genetic variability may not be consistent with the above hypothesis among populations with different social norms governing the institution of marriage, particularly among those that adhere to strict endogamy rules. We test the universality of this hypothesis by analyzing Y-chromosome and mtDNA data in three different sets of Indian populations that follow endogamy rules to varying degrees. Our analysis of the Indian patrilocal and the matrilocal groups is not confirmatory to the sex- specific variation observed among the tribes of Thailand. Our results indicate spatial instability of the impact of different cultural processes on the genetic variability, resulting in the lack of universality of the hypothesized pattern of greater Y-chromosome variation when compared to that of mtDNA among the patrilocal populations.
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix. Here, we describe a role for mt-Hsp70 in chaperoning proteins encoded by mitochondrial DNA and synthesized within mitochondria. The availability of mt-Hsp70 function influences the pattern of proteins synthesized in mitochondria of yeast both in vivo and in vitro. In particular, we show that mt-Hsp70 acts in maintaining the var1 protein, the only mitochondrially encoded subunit of mitochondrial ribosomes, in an assembly competent state, especially under heat stress conditions. Furthermore, mt-Hsp70 helps to facilitate assembly of mitochondrially encoded subunits of the ATP synthase complex. By interacting with the ATP-ase 9 oligomer, mt-Hsp70 promotes assembly of ATP-ase 6, and thereby protects the latter protein from proteolytic degradation. Thus mt-Hsp70 by acting as a chaperone for proteins encoded by the mitochondrial DNA, has a critical role in the assembly of supra- molecular complexes.
Tue, 1 Jan 1980 12:00:00 +0100 https://epub.ub.uni-muenchen.de/5377/1/Zimmermann_Wolfgang_5377.pdf Weissbach, Arthur; Bolden, Arthur; Chen, Shih Min; Zimmermann, Wolfgang ddc:610, Medizin
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