Podcasts about randomisation

VYS0024 | Between Being Real and Not Real - Vayse to Face with Nathan Paul Isaac - Show Notes Barely able to contain their excitement, Hine and Buckley welcome to Vayse the one and only Nathan Paul Isaac, creator of the essential chronicle of high strangeness in Somerset, Kentucky, the Penny Royal podcast. Penny Royal has been a huge influence on Vayse, and Hine and Buckley geek out as the conversation goes deep, wide and weird - from discussion of Penny-Royal-favourite topics such as cybernetics and synchronicity to pondering Hansen's trickster and theories on the nature of elementals and non-human intelligence by way of terrifying stories of faceless dream entities and a firm consensus on the importance of maintaining a healthy hatred of Nazis... and to sweeten the deal even more, Nathan drops a few breadcrumbs as to what kind of weird stuff to expect from Penny Royal season 3... Recorded 6 July 2023 Thanks again to Keith for the show notes - again, we couldn't have have got this episode out on time without his help. We appreciate it! Nathan Paul Isaac / Penny Royal podcast links Penny Royal podcast homepage (https://www.pennyroyalpodcast.com/) Penny Royal podcast Facebook page (https://www.facebook.com/pennyroyalpodcast) Penny Royal/Liminal Lodge patreon page (https://www.patreon.com/PennyRoyal) Penny Royal Twitter page (https://twitter.com/PennyRoyal93) Bringing “Paranormal” Research into the 21st Century with Penny Royal (https://darianwest.medium.com/bringing-paranormal-research-into-the-21st-century-with-penny-royal-eabb2b912f28) - article by Darian West Popular paranormal podcast dives deeper into the Bermuda Triangle of Kentucky, article, Lexington Herald Leader (https://www.kentucky.com/news/state/kentucky/article250527959.html) Transylvania University, Kentucky, wikipedia page (https://en.wikipedia.org/wiki/Transylvania_University) Wikipedia Article on Dan Dutton (https://en.wikipedia.org/wiki/Daniel_Dutton) Kentucky / Kentucky Anomaly links Wikipedia Article on Somerset, Kentucky (https://en.wikipedia.org/wiki/Somerset,_Kentucky) Wikipedia Article on Pulaski County, Kentucky (https://en.wikipedia.org/wiki/Pulaski_County,_Kentucky) Wikipedia Article on Mammoth Cave, Kentucky (https://en.wikipedia.org/wiki/Mammoth_Cave_National_Park) The Kentucky Anomaly, Unusual Kentucky blog, article (https://unusualkentucky.blogspot.com/2008/07/kentucky-anomaly.html) Wikipedia Article on The Kentucky Meat Shower (https://en.wikipedia.org/wiki/Kentucky_meat_shower) NASA Technical Memorandum 82163: Satellite and Surface Geophysical Expression of Anomalous Crustal Structure In Kentucky and Tennessee (https://ntrs.nasa.gov/api/citations/19820009841/downloads/19820009841.pdf) Magnetization models for the source of the ``Kentucky anomaly'' observed by Magsat (abstract only) (https://ui.adsabs.harvard.edu/abs/1985E%26PSL..74..117M/abstract) Appalachia links Wikipedia Article on Appalachia (https://en.wikipedia.org/wiki/Appalachia) Appalachian folklore, monsters, and superstitions (https://blueridgemountainstravelguide.com/appalachian-folklore-and-superstitions/) Appalachian ghost stories in mountain culture (https://www.themoonlitroad.com/appalachian-mountain-culture-ghost-stories/) QAnon and related links Wikipedia Article on QAnon (https://en.wikipedia.org/wiki/QAnon) Wikipedia Article on Jacob Chansley, ‘The QAnon Shaman' (https://en.wikipedia.org/wiki/Jacob_Chansley) Wikipedia Article on January 6 United States Capitol attack (https://en.wikipedia.org/wiki/January_6_United_States_Capitol_attack) Gregory Bateson / Heinz von Foerster / Cybernetics links Wikipedia Article on Gregory Bateson (anthropologist) (https://en.wikipedia.org/wiki/Gregory_Bateson) Gregory Bateson and the ecology of mind (https://www.wildculture.com/article/pattern-connects-gregory-bateson-and-ecology-mind/1213) - Wild Culture article Wikipedia Article on Double bind theory (https://en.wikipedia.org/wiki/Double_bind) Wikipedia Article on Macy conferences (https://en.wikipedia.org/wiki/Macy_conferences) Wikipedia Article on Heinz von Foerster (https://en.wikipedia.org/wiki/Heinz_von_Foerster) Wikipedia Article on Second order cybernetics (https://en.wikipedia.org/wiki/Second-order_cybernetics) John C Lilly / E.C.C.O. / Dolphin experiments / The Order of the Dolphin links John C Lilly website (http://www.johnclilly.com/) Wikipedia Article on John C Lilly (https://en.wikipedia.org/wiki/John_C._Lilly) Wikipedia Article on Programming and Metaprogramming in the Human Biocomputer: Theory and Experiments (book), by John C Lilly (https://en.wikipedia.org/wiki/Programming_and_Metaprogramming_in_the_Human_Biocomputer) Earth Coincidence Control Office (E.C.C.O.) (http://www.whale.to/c/ecco.html) Margaret Howe Lovatt (https://allthatsinteresting.com/margaret-howe-lovatt) - All That's Interesting Article The Girl Who Talked to Dolphins, BBC documentary (59 mins) (https://documentaryheaven.com/girl-who-talked-to-dolphins/) The Order of the Dolphin (https://www.discovermagazine.com/the-sciences/the-order-of-the-dolphin-setis-secret-origin-story) - Discover Magazine Article Wikipedia Article on Frank Drake (https://en.wikipedia.org/wiki/Frank_Drake) Wikipedia Article on Carl Sagan (https://en.wikipedia.org/wiki/Carl_Sagan) Claude Shannon / Information theory links Wikipedia Article on Claude Shannon (https://en.wikipedia.org/wiki/Claude_Shannon) Wikipedia Article on Information theory (https://en.wikipedia.org/wiki/Information_theory) Wikipedia Article on Entropy (information theory) (https://en.wikipedia.org/wiki/Entropy_(information_theory)) Dr Jack Hunter / Deep Weird links Jack Hunter website (https://jack-hunter.yourwebsitespace.com/) Jack Hunter, Facebook page (https://www.facebook.com/DrJackHunter/) Deep Weird: The Varieties of High Strangeness Experience (https://www.abebooks.co.uk/9781786772244/Deep-Weird-Varieties-High-Strangeness-1786772248/plp) by Dr Jack Hunter Review of Deep Weird, Bob Rickard, Fortean Times (https://files.secure.website/wscfus/10184329/31485168/342198527-696195358972961-3934115713297739979-n.jpg) Review of Deep Weird, John Rimmer, Magonia (https://pelicanist.blogspot.com/2023/04/beyond-boogle.html) Ecology and Spirituality: A Brief Introduction (https://www.abebooks.co.uk/servlet/BookDetailsPL?bi=31477689981&searchurl=kn%3DEcology%2Band%2BSpirituality%253A%2BA%2BBrief%2BIntroduction%26sortby%3D17&cm_sp=snippet-_-srp1-_-title1) by Jack Hunter Deleuze / Guattari / Schizophrenia links Wikipedia Article on Anti-Oedipus: Capitalism and Schizophrenia (book) (https://en.wikipedia.org/wiki/Anti-Oedipus) Anti-Oedipus: Capitalism and Schizophrenia (https://uk.bookshop.org/p/books/anti-oedipus-gilles-deleuze/2090088?ean=9781780936611) by Gilles Deleuze and Felix Guattari A Thousand Plateaus: Capitalism and Schizophrenia (book) (https://en.wikipedia.org/wiki/A_Thousand_Plateaus) A Thousand Plateaus: Capitalism and Schizophrenia (https://uk.bookshop.org/p/books/a-thousand-plateaus-capitalism-and-schizophrenia-gilles-deleuze/3023577?ean=9780485113358) by Gilles Deleuze and Felix Guattari Wikipedia Article on Gilles Deleuze (https://en.wikipedia.org/wiki/Gilles_Deleuze) Wikipedia Article on Felix Guattari (https://en.wikipedia.org/wiki/F%C3%A9lix_Guattari) Wikipedia Article on Rhizomatic learning (https://en.wikipedia.org/wiki/Rhizomatic_learning) Wikipedia Article on History of schizophrenia (https://en.wikipedia.org/wiki/History_of_schizophrenia) Wikipedia Article on Folie à deux (shared psychosis, hallucinations) (https://en.wikipedia.org/wiki/Folie_%C3%A0_deux) Paul Devereux links Paul Devereux website (https://pauldevereux.co.uk/) Wikipedia Article on Paul Devereux (https://en.wikipedia.org/wiki/Paul_Devereux) Paul Devereux: Ancient Sites & Their Secrets - Archaeoacoustics - Megalithomania Interview (37 mins) (https://www.youtube.com/watch?v=MxJ78p3GgAo) Powers of Ancient Sacred Places (https://pauldevereux.co.uk/product/uk/book-powers-of-ancient-sacred-places.html) by Paul Devereux Sacred Geometry (https://pauldevereux.co.uk/product/uk/book-sacred-geography.html) by Paul Devereux Marshall McLuhan links Wikipedia Article on “The medium is the message” (https://en.wikipedia.org/wiki/The_medium_is_the_message) Wikipedia Article on Marshall McLuhan (https://en.wikipedia.org/wiki/Marshall_McLuhan) Charles ‘Chuck' Hayes / Danny Casolaro / PROMIS software links Is the FBI Railroading Charles Hayes? (1997) (https://dickrussell.org/1997/06/01/spook-wars-in-cyberspace/) - article by Dick Russell Wikipedia Article on Danny Casolaro (https://en.wikipedia.org/wiki/Danny_Casolaro) The Undying Octopus: FBI and the PROMIS affair (https://www.muckrock.com/news/archives/2017/may/16/FBI-promis-part-1/) - Muck Rock article FBI file casts doubt on Bureau's investigation into the suspicious death of journalist Danny Casolaro (https://www.muckrock.com/news/archives/2017/may/08/fbi-Danny-Casola ro/) - Muck Rock article Carl Jung / Synchronicity / Collective Unconscious / UFOs links Wikipedia Article on Carl Jung (https://en.wikipedia.org/wiki/Carl_Jung) Wikipedia Article on the Collective unconscious (https://en.wikipedia.org/wiki/Collective_unconscious) Wikipedia Article on Synchronicity (https://en.wikipedia.org/wiki/Collective_unconscious) Carl Jung and the Scarab (Jung as intermediary) (https://www.psychologytoday.com/us/blog/connecting-coincidence/202011/the-scarab-jung-created-coincidence-within-coincidence) - Psychology Today Article Jung, Flying Saucers, and the Anxieties of Our Time (https://www.psychologytoday.com/us/blog/dreaming-in-the-digital-age/202012/jung-flying-saucers-and-the-anxieties-our-time) - Psychology Today Article David Bowie UFO experiences links Bowie's 1967 UFO sighting (https://www.reddit.com/r/UFOs/comments/tvn6am/david_bowie_about_his_ufo_sighting/) Bowie shares his UFO experiences (https://www.paranormalpopculture.com/2019/02/david-bowie-shares-his-ufo-experiences.html) Other links Wikipedia Page on The Mothman Prophecies (book), by John Keel (https://en.wikipedia.org/wiki/The_Mothman_Prophecies) The Mothman Prophecies (https://uk.bookshop.org/p/books/the-mothman-prophecies-john-a-keel/2074568?ean=9780765334985) by John Keel (https://en.wikipedia.org/wiki/John_Keel) Wikipedia Article on Cosmic Trigger: The Final Secret of the Illuminati (book), by Robert Anton Wilson (https://en.wikipedia.org/wiki/Cosmic_Trigger_I%3A_The_Final_Secret_of_the_Illuminati) Cosmic Trigger I: The Final Secret of the Illuminati (https://www.abebooks.co.uk/book-search/title/cosmic-trigger/author/robert-wilson/) by Robert Anton Wilson Sinister Forces-The Nine: A Grimoire of American Political Witchcraft (https://uk.bookshop.org/p/books/sinister-forces-the-nine-a-grimoire-of-american-political-witchcraft-peter-levenda/4500283?ean=9780984185818) by Peter Levenda Wikipedia Article on Watergate scandal (https://en.wikipedia.org/wiki/Watergate_scandal) Wikipedia Article on the September 11 attacks (https://en.wikipedia.org/wiki/September_11_attacks) Wikipedia Article on James Shelby Downard (https://en.wikipedia.org/wiki/James_Shelby_Downard) Wikipedia Article on Pan (god) (https://en.wikipedia.org/wiki/Pan_(god)) Wikipedia Article on Puck (folklore) (https://en.wikipedia.org/wiki/Puck_(folklore)) Bob Freeman's blog (https://authorbobfreeman.wordpress.com/) VYS0017 | Occult Detective - Vayse to Face with Bob Freeman (https://www.vayse.co.uk/vys0017) Hellier (tv series), website (https://www.hellier.tv/) Hellier (https://www.youtube.com/watch?v=R1FwIuicx88) Wikipedia Article on Post-truth (https://en.wikipedia.org/wiki/Post-truth) Radicalisation by technology (https://www.theguardian.com/world/2021/feb/14/how-far-right-uses-video-games-tech-lure-radicalise-teenage-recruits-white-supremacists) - Guardian Article Wikipedia Article on Cambridge Analytica (https://en.wikipedia.org/wiki/Cambridge_Analytica) Wikipedia Article on Wagner group (https://en.wikipedia.org/wiki/Wagner_Group) Reptilians in the basement of a pizza parlour (https://www.rollingstone.com/feature/anatomy-of-a-fake-news-scandal-125877/) - Rolling Stone Article Shape-shifter on a plane (https://www.eviemagazine.com/post/everything-we-know-woman-on-plane-who-passenger-was-not-real-see) Evie Magazine Article Wikipedia Article on Tracing (philosophical concept) (https://en.wikipedia.org/wiki/Trace_(deconstruction)) Wikipedia Article on Hyperlinks, history (https://en.wikipedia.org/wiki/Hyperlink#History) Emergent properties (https://plato.stanford.edu/entries/properties-emergent/) - Stanford Encyclopaedia of Philosophy Article Wikipedia Article on Egregores (https://en.wikipedia.org/wiki/Egregore) Thoughtforms, Tulpas & Egregores (https://www.planet-today.com/2021/08/thoughtforms-tulpas-egregores.html) - Planet Today Article Euphomet podcast website (https://www.euphomet.com/) Wikipedia Article on 11:11 (numerology) (https://en.wikipedia.org/wiki/11:11_(numerology)) Wikipedia Article on 23 enigma (https://en.wikipedia.org/wiki/23_enigma) Greg Newkirk, website (https://gregorynewkirk.com/) Wikipedia Article on the Observer effect (physics) (https://en.wikipedia.org/wiki/Observer_effect_(physics)) Wikipedia Article on Cosmic Microwave background (https://en.wikipedia.org/wiki/Cosmic_microwave_background) Wikipedia Article on I Ching (https://en.wikipedia.org/wiki/I_Ching) I Ching (https://uk.bookshop.org/books/i-ching-or-book-of-changes-ancient-chinese-wisdom-to-inspire-and-enlighten/9780140192070) – The Wilhelm/Baynes 3rd edition Wikipedia Article on Johannes Trithemius (cryptographer, occultist) (https://en.wikipedia.org/wiki/Johannes_Trithemius) Joe Simonton and the Space Pancakes (https://www.ufoinsight.com/aliens/encounters/eagle-river-incident), - UFO Insight Article Wikipedia Article on Jacques Vallee (https://en.wikipedia.org/wiki/Jacques_Vall%C3%A9e) The Trickster and the Paranormal (book) by George P Hansen, website (http://tricksterbook.com/) Uri Geller's website (https://www.urigeller.com/) Wikipedia Article on Harold ‘Hal' Puthoff (https://en.wikipedia.org/wiki/Harold_E._Puthoff) Wikipedia Article on Stargate Project (https://en.wikipedia.org/wiki/Stargate_Project) Paranormal Research is Not About Science, It's Talking To People (https://www.spookyisles.com/paranormal-research-vs-science/) - Spooky Isles Article Wikipedia Article on Fortean Times (https://en.wikipedia.org/wiki/Fortean_Times) Wikipedia Article on Steve Moore (writer) (https://en.wikipedia.org/wiki/Steve_Moore_(comics)) Wikipedia Article on Yin and Yang (https://en.wikipedia.org/wiki/Yin_and_yang) Wikipedia Article on Taoism (https://en.wikipedia.org/wiki/Taoism) Spontaneous Human Combustion (https://www.vice.com/en/article/kwgbbe/the-learning-corner-705-v18n2) article by Larry Arnold Wikipedia Article on the Uncertainty principle (https://en.wikipedia.org/wiki/Uncertainty_principle) Wikipedia Article on Mark Pilkington (https://en.wikipedia.org/wiki/Mark_Pilkington_(writer)) VYS0020 | Messages of Deception - Vayse to Face with Mark Pilkington (https://www.vayse.co.uk/vys0020) Wikipedia Article on Chaos Magic (https://en.wikipedia.org/wiki/Chaos_magic) Wikipedia Article on Autotomy (self-amputation) (https://en.wikipedia.org/wiki/Autotomy) Aerosmith and outside writers (https://faroutmagazine.co.uk/why-aerosmith-only-had-one-number-one-song/) - Far Out Magazine Article Penny Royal Season 1 Episode 4 (https://www.podbean.com/media/share/dir-tqbri-bc0ae7b?utm_campaign=w_share_ep&utm_medium=dlink&utm_source=w_share) - the Elkhorn Episode Dungeons and Dragons (https://dnd.wizards.com/) Why Satanic Panic never really ended (https://www.vox.com/culture/22358153/satanic-panic-ritual-abuse-history-conspiracy-theories-explained) - Vox Article on the Satanic Panic Necronomicon (https://www.holybooks.com/wp-content/uploads/The-Simon-Necronomicon.pdf) by Simon Smoke Monster from Lost (https://lostpedia.fandom.com/wiki/The_Man_in_Black) Lost (https://www.youtube.com/watch?v=4hBI7ijfXE8) Deer Rutting Noises (https://www.youtube.com/watch?v=YHXKLM0d-lc) Tatton Park (https://www.tattonpark.org.uk/home.aspx) VYS0007 | Too Much to Dream Last Night (https://www.vayse.co.uk/vys0007) - The Story of Buckley's synchronicities and Hine's encounter with Pan Stories from The Messengers: Accounts of Owls, UFOs and a Deeper Reality (https://bookshop.org/p/books/stories-from-the-messengers-accounts-of-owls-ufos-and-a-deeper-reality-mike-clelland/15085331)by Mike Clelland Whiterock Lake Weekly article on Rabbits as Liminal Creatures (https://whiterocklakeweekly.com/shape-shifting-hare-part-of-easter-folklore/) Wikipedia Article on Púcas (https://en.wikipedia.org/wiki/P%C3%BAca) Watership Down (https://en.wikipedia.org/wiki/P%C3%BAca) Facebook Page for Somerset High School Briar Jumpers (https://www.facebook.com/groups/SHSFOOTBALL2011/) Donnie Darko Trailer (https://www.youtube.com/watch?v=ZZyBaFYFySk) Wikipedia Article on Elementals (https://en.wikipedia.org/wiki/Elemental) Tea and Rosemary Article on the Fae (https://teaandrosemary.com/fae-folk-fair-folk-faeries-fairies/) VYS0021 | Song of the Dark Man - Vayse to Face with Darragh Mason (https://www.vayse.co.uk/vys0021) – Interview with Darragh Mason Nathan on the Spirit Box Podcast (https://www.youtube.com/watch?v=gQa9C9oWrow) The Strange Familiars Podcast - Flannel Man: More than a Ghost (https://www.strangefamiliars.com/home/flannel-man-more-than-a-ghost) Nathan Interviewed on Strange Familiars (https://www.strangefamiliars.com/home/penny-royal-part-1) Slay Away Article - 10 Unsettling Films Featuring Ouija Boards to Connect You with Spirits (https://www.slayawaywithus.com/post/octf-10-unsettling-films-featuring-ouija-boards-to-connect-you-with-spirits) Wikipedia Article on Chapel Perilous (https://en.wikipedia.org/wiki/Chapel_perilous) Daily Voice Article on the Wanaque Reservoir Flap (https://dailyvoice.com/new-jersey/northpassaic/news/50-years-later-wanaque-reservoir-ufo-photographer-identified/724531/) VYS0010 | Amazing Stories - Vayse to Face with Dr Allen H Greenfield Pt.1 (https://www.vayse.co.uk/vys0010) – Interview with Dr Allen H Greenfield Wikipedia Article on Ostension (https://en.wikipedia.org/wiki/Ostension) Dark Marvels (https://www.youtube.com/watch?v=2pGXzemLtJU) – Trailer for the new show that Nathan has written for Wikipedia Article on Russian Roulette (https://en.wikipedia.org/wiki/Russian_roulette) The Golden Bough (https://uk.bookshop.org/p/books/the-golden-bough-abridged-edition-sir-james-george-frazer/1144152?ean=9780486836102) by Sir James George Frazer Wikipedia Article on James Shelby Downard Jr (https://en.wikipedia.org/wiki/James_Shelby_Downard) Wikipedia Article on Medford Bryan Evans (https://en.wikipedia.org/wiki/Medford_Bryan_Evans) Wikipedia Article on the John Birch Society (https://en.wikipedia.org/wiki/John_Birch_Society) Wikipedia Article on Black Helicopters (https://en.wikipedia.org/wiki/Black_helicopter) Hookland (https://hookland.wordpress.com/) Hookland Twitter Account (https://twitter.com/hooklandguide?s=21&t=q2-c9hjD5sIXynDdaJB8PQ) The case for Brexit was built on lies. Five years later, deceit is routine in our politics (https://www.theguardian.com/commentisfree/2021/jun/27/case-for-brexit-built-on-lies-five-years-later-deceit-is-routine-in-our-politics) - Guardian Article Wikipedia Article on the BNP (https://en.wikipedia.org/wiki/British_National_Party) Wikipedia Article on UKIP (https://en.wikipedia.org/wiki/UK_Independence_Party) Twin Peaks (https://www.youtube.com/watch?v=j8-KTdNdizE) Article on the Charity Commission inquiry into the Captain Tom Foundation (https://www.theguardian.com/uk-news/2023/jul/04/capt-tom-foundation-closes-to-donations-as-council-orders-building-demolition) Ghostbusters Trailer (https://www.youtube.com/watch?v=6hDkhw5Wkas) The Real Ghostbusters Promo Pilot (https://www.youtube.com/watch?v=VeNiQKwHclI) Ghostbusters' Wiki Article on Tobin's Spirit Guide (https://ghostbusters.fandom.com/wiki/Tobin%27s_Spirit_Guide) Tobin's Spirit Guide (https://uk.bookshop.org/p/books/tobin-s-spirit-guide-erik-burnham/4327595?ean=9781785654084) by Erik Burnham and Kyle Hotz Special Guest: Nathan Paul Isaac.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.28.517913v1?rss=1 Authors: Haglund, A., Zuber, V., Yang, Y., Abouzeid, M., Feleke, R., Ko, J.-H., Nott, A., Babtie, A. C., Mills, J. D., Muhammed, L., Laaniste, L., Gveric, D. O., Clode, D., Pagni, S., Bellampalli, R., Somani, A., McDade, K., Anink, J. J., Mesarosova, L., Aronica, E., Thom, M., Sisodiya, S. M., Srivastava, P. K., Malhotra, D., Bryois, J., Bottolo, L., Johnson, M. R. Abstract: Translating genome-wide association loci to therapies requires knowledge of the causal genes, their directionality of effect and the cell-types in which they act. To infer these relationships in the human brain, we implemented Mendelian randomisation using single cell-type expression quantitative trait loci (eQTLs) as genetic anchors. Expression QTLs were mapped across 8 major cell-types in brain tissue exclusively ascertained from donors with no history of brain disease. We report evidence for a causal association between the change in expression of 118 genes and one or more of 16 brain phenotypes, revealing candidate targets for risk mitigation and opportunities for shared preventative therapeutic strategies. We highlight key causal genes for neurodegenerative and neuropsychiatric disease and for each, we report its cellular context and the therapeutic directionality required for risk mitigation. Our use of control samples establishes a new resource for the causal interpretation of GWAS risk alleles for human brain phenotypes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Randomisation. A very serious note. --- Send in a voice message: https://anchor.fm/vikki-semple/message

Salam, Dans cet épisode, je vous raconte trois histoires incroyables. Des histoires qui ont révolutionné la médecine mais également les sciences en général. Trois histoires, trois personnages hors du commun, trois questions fondamentales, pour une invention qui a tout révolutionné, pour une humanité qui s'en est trouvée grandie, au bénéfice de millions de vies sauvées... Retrouvez-nous aussi sur Instagram, Facebook ainsi que le blog : https://le-criterium.com/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

In today's podcast I talk about: My busy day today. Randomisation with a corporate event and with a live session. How to make a relationship work? Stop living a virtual life and live a human life. Respecting each other's differences.

MAC Randomisation in WiFi - how is it going to affect you? Listen to Jim Palmer sharing his expertise and experience about MAC randomisation and learn how to prepare your network for this change!

In today's podcast I talk about: My camp feedback. How to enable others to take decisions. How to be aware of Randomisation. How not to randomise others. Not forcing others. Peer pressure.

In today's podcast I talk about: My talk with IBS students. My foundation Training session. India Australia test match. How to handle Randomisation? Big win today for me and India.

Paper for discussion: Perianal block with ropivacaine as a supplement to anaesthesia in proctological surgery: double‐blind randomized placebo‐controlled trial (PERCEPT), BJS March 2020 Teaching topic: Randomised Clinical Trials, Randomisation and Bliding. Our tune is"Inspiring Optimistic Upbeat Energetic Guitar Rhythm" by Free Music | https://soundcloud.com/fm_freemusic Music promoted by https://www.free-stock-music.com Creative Commons Attribution 3.0 Unported License https://creativecommons.org/licenses/by/3.0/deed.en_US

What makes something worth reading?PopulationFindingsTypes of studies - epidemiological, vs clinical trial etc..To really understand a study you need to read more than just the abstract. The abstract is a great introduction however doesn’t give us enough context or information.Each of the different studies have their own strengths and weaknesses. To summarise: Evidence Summaries (Systematic Reviews and Meta-analysis)Experimental studies (RCT’s and non-RCT’s)Observational studies (case control, case report, cohort study)Source: https://www.researchgate.net/publication/311504831_Options_for_basing_Dietary_Reference_Intakes_DRIs_on_chronic_disease_endpoints_report_from_a_joint_US-Canadian-sponsored_working_groupCASP (and other critical appraisal) toolshttps://casp-uk.net/casp-tools-checklists/Type of study - RCT vs cohort/observational vs systematic review vs case control. In vitro (test tube) vs in vivo, Animal vs humanRandomized, double-blind, placebo-controlled trials = gold standard Aims and study qnHow were subject recruited?Randomisation and blindingPopulation size + power of the findings - the bigger the sample size, the more reliable the study is.Demographics - age, sex, health status - this will help you indetify if the paper is relevant to you or your client group. No point in drawing inferences from a paper which looks at muscle mass in an elderly population group if the group you work with are

Replication, Randomisation and Rigour: AIMOS 2019. This talk was delivered at the launch of the Association for Inter-disciplinary Meta-research and Open Science on 7 November 2019 at the University of Melbourne.

Objectives: To investigate the role of body mass index (BMI), systolic blood pressure, and smoking behaviour in explaining the effect of education on the risk of cardiovascular disease outcomes. Design: Mendelian randomisation study. Setting: UK Biobank and international genome-wide association study data. Participants: Predominantly participants of European ancestry. Exposure: Educational attainment, BMI, systolic blood pressure, and smoking behaviour in observational analysis, and randomly allocated genetic variants to instrument these traits in mendelian randomisation. Main outcomes measure: The risk of coronary heart disease, stroke, myocardial infarction, and cardiovascular disease (all subtypes; all measured in odds ratio), and the degree to which this is mediated through BMI, systolic blood pressure, and smoking behaviour respectively. Results: Each additional standard deviation of education (3.6 years) was associated with a 13% lower risk of coronary heart disease (odds ratio 0.86, 95% confidence interval 0.84 to 0.89) in observational analysis and a 37% lower risk (0.63, 0.60 to 0.67) in mendelian randomisation analysis. As a proportion of the total risk reduction, BMI was estimated to mediate 15% (95% confidence interval 13% to 17%) and 18% (14% to 23%) in the observational and mendelian randomisation estimates, respectively. Corresponding estimates were 11% (9% to 13%) and 21% (15% to 27%) for systolic blood pressure and 19% (15% to 22%) and 34% (17% to 50%) for smoking behaviour. All three risk factors combined were estimated to mediate 42% (36% to 48%) and 36% (5% to 68%) of the effect of education on coronary heart disease in observational and mendelian randomisation analyses, respectively. Similar results were obtained when investigating the risk of stroke, myocardial infarction, and cardiovascular disease. Conclusions: BMI, systolic blood pressure, and smoking behaviour mediate a substantial proportion of the protective effect of education on the risk of cardiovascular outcomes and intervening on these would lead to reductions in cases of cardiovascular disease attributable to lower levels of education. However, more than half of the protective effect of education remains unexplained and requires further investigation. Carter AR, Gill D, Davies NM, et al. Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study. BMJ. 2019;365:l1855. Published 2019 May 22. doi:10.1136/bmj.l1855 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/. Sections of the Abstract, Introduction, and Discussion are presented in the Podcast. Link to the full-text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529852/

Professor David Torgerson, Director of the York Trials Unit, gives a talk for the Evidence Based Healthcare podcast series. He has published widely with over 250 peer reviewed papers many of them on the design of randomised trials including a student text book 'Designing Randomised Trials in Health Education and the Social Sciences' (2008, Palgrave MacMillan). He has a particular interest in the design and conduct of cluster randomised trials. Randomisation, if conducted properly, will abolish selection bias. Poor randomisation practice for individually randomised trials allows the allocation schedule to be predicted and can lead to subversion of the randomisation, which introduces selection bias. In cluster randomised controlled trials there is a particular problem with some trials in that cluster randomisation occurs before individual recruitment. When this occurs the allocation can become known to the potential participant and the recruiting clinician and research. This, then, allows selective recruitment to occur which means that selection bias is introduced at the level of the individual participant. In this talk the problem is illustrated in case studies and I discuss approaches to dealing with this potential source of selection bias.

Professor David Torgerson, Director of the York Trials Unit, gives a talk for the Evidence Based Healthcare podcast series. He has published widely with over 250 peer reviewed papers many of them on the design of randomised trials including a student text book 'Designing Randomised Trials in Health Education and the Social Sciences' (2008, Palgrave MacMillan). He has a particular interest in the design and conduct of cluster randomised trials. Randomisation, if conducted properly, will abolish selection bias. Poor randomisation practice for individually randomised trials allows the allocation schedule to be predicted and can lead to subversion of the randomisation, which introduces selection bias. In cluster randomised controlled trials there is a particular problem with some trials in that cluster randomisation occurs before individual recruitment. When this occurs the allocation can become known to the potential participant and the recruiting clinician and research. This, then, allows selective recruitment to occur which means that selection bias is introduced at the level of the individual participant. In this talk the problem is illustrated in case studies and I discuss approaches to dealing with this potential source of selection bias.

In this live recording of the ninth #UnblindingResearch session on 'Randomisation' from DREEAM through a randomising the audience to wine gum or jelly babies. By the end of this you should have randomisation sorted! The blog entry containing the slides, #TakeVisually and more info can be found at https://www.takeaurally.com/new-blog-1/2018/11/12/randomisation-1 Subscribe to Take Aurally on SoundCloud and iTunes Remember you can find Take Aurally and NUH DREEAM on both Facebook and Twitter The amazing DREEAM Research Team can be found on both Facebook and Twitter Our next #UnblindingResearch session will be on Blinding on 19th December 1000-1100 in DREEAM. Next week's episode will be our third Redthread special!

In this live recording of the eighth #UnblindingResearch session on 'Outcome Measures, Confidence Intervals and p values' from DREEAM through a made up beta blocker 'Superlol' we go through: - p values and significance - how mean values move and standard error of the mean - how outcome measures are made and revisiting QALYs Don't be mean and bear the pressure! The blog entry containing the slides, #TakeVisually and more info can be found at https://www.takeaurally.com/new-blog-1/2018/9/30/outcome-measures Subscribe to Take Aurally on SoundCloud and iTunes Remember you can find Take Aurally and NUH DREEAM on both Facebook and Twitter The amazing DREEAM Research Team can be found on both Facebook and Twitter Our next #UnblindingResearch session will be on Randomisation on 21st November 1000-1100 in DREEAM. Next week's episode will be on Cardiac History Taking

Mendelian randomisation - it's a technique that uses the chance distribution of genes in a population, combined with big data sets, to investigate causative relationships. But there are a lot of questions we have in The BMJ about how the technique works - the association between genes and apparently non-biologically mediated behaviours, how much the strict rule of not claiming causation based on observational data has actually been overturned, and general confusion about how the non-methodologists amongst us can read these studies. Neil Davies and George Davey Smith from University of Bristol, and Michael Holmes from the University of Oxford, join us to explain how the technique works, where it can be applied, and what readers should look out for when they're trying to assess the quality of a mendelian randomisation study. Read their full research methods and reporting paper: https://www.bmj.com/content/362/bmj.k601

Hej! Äntligen är Ortopoddens första avsnitt ute! Jag pratar om collum chirurgicum-frakturer med docent Kalle Lunsjö från Helsingborgs Lasarett. Vi diskuterade bl.a. PRoFHER-studien som finns i fulltext under följande länk: The ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation) trial I diskussionen kring vad som är en acceptabel axelrörlighet finns det en intressant studie från 2012: Defining functional shoulder range of motion for activities of daily living. Kalle Lunsjö bjöd också på sina fem bästa tips för att undvika fallgropar: Distalstatus  Cuffskada? Reponera inte innan röntgen Glöm inte glenoiden Bakre luxation kan vara svårt att upptäcka   Podden hittar du där poddar finns! Vi hörs snart igen!

Clarification of new evidence that Bisphosphonates for osteoporosis may actually weaken bones if people are left on them for too long ; Dietary change using FODMAPS to treat Irritable bowel syndrome when medicines have not worked; CRP testing for chest infections to identify which need antibiotics; And Mark eats humble pie for getting clinical terminology mixed up.

England nach dem 2. Weltkrieg: Tuberkulose gehört zu den wichtigsten Todesursachen bei jungen Menschen. Wie zuverlässig hilft Streptomycin? Das untersucht der Medizinstatistiker Austin Bradford Hill mit äußerst knappen Mitteln und einer neuen Methodik: einer randomisierten kontrollierten Studie.

Allocation concealment - blinding which arm of a trial a patient is randomised to - is being questioned in an analysis published on thebmj.com. David Torgerson, director of the York Trials Unit at the university of York and colleagues have been looking at the way in which trials do this randomisation, and how they subsequently report it - and have found both lacking. Read the full analysis: http://www.bmj.com/content/355/bmj.i5663

Our series on critical appraisal nuggets in 5-10 mins. This week it's Randomisation. Great if you are revising for an exam in critical appraisal (e.g. FRCEM).

Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial Andrew Appelboam, FRCEM, Adam Reuben, FRCEM, Clifford Mann, FRCEM, James Gagg, FRCEM, Prof Paul Ewings, PhD, Andrew Barton, MSc, Trudie Lobban, MRCP, Mark Dayer, FRCP, Jane Vickery, MSc, Prof Jonathan Benger, MD on behalf of the REVERT trial collaborators The Lancet. 2015; DOI:10.1016/S0140-6736(15)61485-4 Published Online: 24 August 2015 Background: The Valsalva manoeuvre is an internationally recommended treatment for supraventricular tachycardia, but cardioversion is rare in practice (5–20%), necessitating the use of other treatments including adenosine, which patients often find unpleasant. Researchers assessed whether a postural modification to the Valsalva manoeuvre could improve its effectiveness. Methods: The study authors did a randomised controlled, parallel-group trial at emergency departments in England. They randomly allocated adults presenting with supraventricular tachycardia (excluding atrial fi brillation and flutter) in a 1:1 ratio to undergo a modified Valsalva manoeuvre (done semi-recumbent with supine repositioning and passive leg raise immediately after the Valsalva strain), or a standard semi-recumbent Valsalva manoeuvre. A 40 mm Hg pressure, 15 s standardised strain was used in both groups. Randomisation, stratified by centre, was done centrally and independently, with allocation with serially numbered, ...

Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial Andrew Appelboam, FRCEM, Adam Reuben, FRCEM, Clifford Mann, FRCEM, James Gagg, FRCEM, Prof Paul Ewings, PhD, Andrew Barton, MSc, Trudie Lobban, MRCP, Mark Dayer, FRCP, Jane Vickery, MSc, Prof Jonathan Benger, MD on behalf of the REVERT trial collaborators The Lancet. 2015; DOI:10.1016/S0140-6736(15)61485-4 Published Online: 24 August 2015 Background: The Valsalva manoeuvre is an internationally recommended treatment for supraventricular tachycardia, but cardioversion is rare in practice (5–20%), necessitating the use of other treatments including adenosine, which patients often find unpleasant. Researchers assessed whether a postural modification to the Valsalva manoeuvre could improve its effectiveness. Methods: The study authors did a randomised controlled, parallel-group trial at emergency departments in England. They randomly allocated adults presenting with supraventricular tachycardia (excluding atrial fi brillation and flutter) in a 1:1 ratio to undergo a modified Valsalva manoeuvre (done semi-recumbent with supine repositioning and passive leg raise immediately after the Valsalva strain), or a standard semi-recumbent Valsalva manoeuvre. A 40 mm Hg pressure, 15 s standardised strain was used in both groups. Randomisation, stratified by centre, was done centrally and independently, with allocation with serially numbered, ...

Transient experiments with picosecond laser pulses give valuable information on the dynamic properties of polyatomic molecules in the electronic ground state. In small molecules the decay of vibrational energy occurs via individual lower energy states; in large molecules the experimental data support a statistical model.