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Continuum Audio
Multidisciplinary Treatment for Functional Movement Disorder With Dr. Jon Stone

Continuum Audio

Play Episode Listen Later Oct 1, 2025 28:17


Functional movement disorders are a common clinical concern for neurologists. The principle of “rule-in” diagnosis, which involves demonstrating the difference between voluntary and automatic movement, can be carried through to explanation, triage, and evidence-based multidisciplinary rehabilitation therapy. In this episode, Gordon Smith, MD, FAAN speaks Jon Stone, PhD, MB, ChB, FRCP, an author of the article “Multidisciplinary Treatment for Functional Movement Disorder” in the Continuum® August 2025 Movement Disorders issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Stone is a consultant neurologist and honorary professor of neurology at the Centre for Clinical Brain Sciences at the University of Edinburgh in Edinburgh, United Kingdom. Additional Resources Read the article: Multidisciplinary Treatment for Functional Movement Disorder Subscribe to Continuum®: shop.lww.com/Continuum Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Guest: @jonstoneneuro Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. This exclusive Continuum Audio interview is available only to you, our subscribers. We hope you enjoy it. Thank you for listening. Dr Smith: Hello, this is Dr Gordon Smith. Today I've got the great pleasure of interviewing Dr Johnstone about his article on the multidisciplinary treatment for functional neurologic disorder, which he wrote with Dr Alan Carson. This article will appear in the August 2025 Continuum issue on movement disorders. I will say, Jon, that as a Continuum Audio interviewer, I usually take the interviews that come my way, and I'm happy about it. I learn something every time. They're all a lot of fun. But there have been two instances where I go out and actively seek to interview someone, and you are one of them. So, I'm super excited that they allowed me to talk with you today. For those of our listeners who understand or are familiar with FND, Dr Stone is a true luminary and a leader in this, both in clinical care and research. He's also a true humanist. And I have a bit of a bias here, but he was the first awardee of the Ted Burns Humanism in Neurology award, which is a real honor and reflective of your great work. So welcome to the podcast, Jon. Maybe you can introduce yourself to our audience. Dr Stone: Well, thank you so much, Gordon. It was such a pleasure to get that award, the Ted Burns Award, because Ted was such a great character. I think the spirit of his podcasts is seen in the spirit of these podcasts as well. So, I'm a neurologist in Edinburgh in Scotland. I'm from England originally. I'm very much a general neurologist still. I still work full-time. I do general neurology, acute neurology, and I do two FND clinics a week. I have a research group with Alan Carson, who you mentioned; a very clinical research group, and we've been doing that for about 25 years. Dr Smith: I really want to hear more about your clinical approach and how you run the clinic, but I wonder if it would be helpful for you to maybe provide a definition. What's the definition of a functional movement disorder? I mean, I think all of us see these patients, but it's actually nice to have a definition. Dr Stone: You know, that's one of the hardest things to do in any paper on FND. And I'm involved with the FND society, and we're trying to get together a definition. It's very hard to get an overarching definition. But from a movement disorder point of view, I think you're looking at a disorder where there is an impairment of voluntary movement, where you can demonstrate that there is an automatic movement, which is normal in the same movement. I mean, that's a very clumsy way of saying it. Ultimately, it's a disorder that's defined by the clinical features it has; a bit like saying, what is migraine? You know? Or, what is MS? You know, it's very hard to actually say that in a sentence. I think these are disorders of brain function at a very broad level, and particularly with FND disorders, of a sort of higher control of voluntary movement, I would say. Dr Smith: There's so many pearls in this article and others that you've written. One that I really like is that this isn't a diagnosis of exclusion, that this is an affirmative diagnosis that have clear diagnostic signs. And I wonder if you can talk a little bit about the diagnostic process, arriving at an FND diagnosis for a patient. Dr Stone: I think this is probably the most important sort of “switch-around” in the last fifteen, twenty years since I've been involved. It's not new information. You know, all of these diagnostic signs were well known in the 19th century; and in fact, many of them were described then as well. But they were kind of lost knowledge, so that by the time we got to the late nineties, this area---which was called conversion disorder then---it was written down. This is a diagnosis of exclusion that you make when you've ruled everything out. But in fact, we have lots of rule in signs, which I hope most listeners are familiar with. So, if you've got someone with a functional tremor, you would do a tremor entrainment test where you do rhythmic movements of your thumb and forefinger, ask the patient to copy them. It's very important that they copy you rather than make their own movements. And see if their tremor stops briefly, or perhaps entrains to the same rhythm that you're making, or perhaps they just can't make the movement. That might be one example. There's many examples for limb weakness and dystonia. There's a whole lot of stuff to learn there, basically, clinical skills. Dr Smith: You make a really interesting point early on in your article about the importance of the neurological assessment as part of the treatment of the patient. I wonder if you could talk to our listeners about that. Dr Stone: So, I think, you know, there's a perception that- certainly, there was a perception that that the neurologist is there to make a diagnosis. When I was training, the neurologist was there to tell the patient that they didn't have the kind of neurological problem and to go somewhere else. But in fact, that treatment process, when it goes well, I think begins from the moment you greet the patient in the waiting room, shake their hand, look at them. Things like asking the patient about all their symptoms, being the first doctor who's ever been interested in their, you know, horrendous exhaustion or their dizziness. You know, questions that many patients are aware that doctors often aren't very interested in. These are therapeutic opportunities, you know, as well as just taking the history that enable the patient to feel relaxed. They start thinking, oh, this person's actually interested in me. They're more likely to listen to what you've got to say if they get that feeling off you. So, I'd spend a lot of time going through physical symptoms. I go through time asking the patient what they do, and the patients will often tell you what they don't do. They say, I used to do this, I used to go running. Okay, you need to know that, but what do they actually do? Because that's such valuable information for their treatment plan. You know, they list a whole lot of TV shows that they really enjoy, they're probably not depressed. So that's kind of useful information. I also spend a lot of time talking to them about what they think is wrong. Be careful, that they can annoy patients, you know. Well, I've come to you because you're going to tell me what's wrong. But what sort of ideas had you had about what was wrong? I need to know so that I can deal with those ideas that you've had. Is there a particular reason that you're in my clinic today? Were you sent here? Was it your idea? Are there particular treatments that you think would really help you? These all set the scene for what's going to come later in terms of your explanation. And, more importantly, your triaging of the patient. Is this somebody where it's the right time to be embarking on treatment, which is a question we don't always ask yourself, I think. Dr Smith: That's a really great point and kind of segues to my next question, which is- you talked a little bit about this, right? Generally speaking, we have come up with this is a likely diagnosis earlier, midway through the encounter. And you talked a little bit about how to frame the encounter, knowing what's coming up. And then what's coming up is sharing with the patient our opinion. In your article, you point out this should be no different than telling someone they have Parkinson's disease, for instance. What pearls do you have and what pitfalls do you have in how to give the diagnosis? And, you know, a lot of us really weren't trained to do this. What's the right way, and what are the most common land mines that folks step on when they're trying to share this information with patients? Dr Stone: I've been thinking about this for a long time, and I've come to the conclusion that all we need to do with this disorder is stop being weird. What goes wrong? The main pitfall is that people think, oh God, this is FND, this is something a bit weird. It's in a different box to all of the other things and I have to do something weird. And people end up blurting out things like, well, your scan was normal or, you haven't got epilepsy or, you haven't got Parkinson's disease. That's not what you normally do. It's weird. What you normally do is you take a deep breath and you say, I'm sorry to tell you've got Parkinson's disease or, you have this type of dystonia. That's what you normally say. If you follow the normal- what goes wrong is that people don't follow the normal rules. The patient picks up on this. What's going on here? This doctor's telling me what I don't have and then they're starting to talk about some reason why I've got this, like stress, even though I don't- haven't been told what it is yet. You do the normal rules, give it a name, a name that you're comfortable with, preferably as specific as possible: functional tremor, functional dystonia. And then do what you normally do, which is explain to the patient why you think it's this. So, if someone's got Parkinson's, you say, I think you've got Parkinson's because I noticed that you're walking very slowly and you've got a tremor. And these are typical features of Parkinson. And so, you're talking about the features. This is where I think it's the most useful thing that you can do. And the thing that I do when it goes really well and it's gone badly somewhere else, the thing I probably do best, what was most useful, is showing the patient their signs. I don't know if you do that, Gordon, but it's maybe not something that we're used to doing. Dr Smith: Wait, maybe you can talk more about that, and maybe, perhaps, give an example? Talk about how that impacts treatment. I was really impressed about the approach to physical therapy, and treatment of patients really leverages the physical examination findings that we're all well-trained to look for. So maybe explore that a little bit. Dr Stone: Yeah, I think absolutely it does. And I think we've been evolving these thoughts over the last ten or fifteen years. But I started, you know, maybe about twenty years ago, started to show people their tremor entrainment tests. Or their Hoover sign, for example; if you don't know Hoover sign, weakness of hip extension, that comes back to normal when the person's flexing their normal leg, their normal hip. These are sort of diagnostic tricks that we had. Ahen I started writing articles about FND, various senior neurologists said to me, are you sure you should write this stuff down? Patients will find out. I wrote an article with Marc Edwards called “Trick or Treat in Neurology” about fifteen years ago to say that actually, although they're they might seem like tricks, there really are treats for patients because you're bringing the diagnosis into the clinic room. It's not about the normal scan. You can have FND and MS. It's not about the normal scan. It's about what you're seeing in front of you. If you show that patient, yes, you can't move your leg. The more you try, the worse it gets. I can see that. But look, lift up your other leg. Let me show you. Can you see now how strong your leg is? It's such a powerful way of communicating to the patient what's wrong with them diagnostically, giving them that confidence. What it's also doing is showing them the potential for improvement. It's giving them some hope, which they badly need. And, as we'll perhaps talk about, the physio treatment uses that as well because we have to use a different kind of physio for many forms of functional movement disorder, which relies on just glimpsing these little moments of normal function and promoting them, promoting the automatic movement, squashing down that abnormal pattern of voluntary movement that people have got with FND. Dr Smith: So, maybe we can talk about that now. You know, I've got a bunch of other questions to ask you about mechanism and stuff, but let's talk about the approach to physical therapy because it's such a good lead-in and I always worry that our physical therapists aren't knowledgeable about this. So, maybe some examples, you have some really great ones in the article. And then words of wisdom for us as we're engaging physical therapists who may not be familiar with FND, how to kind of build that competency and relationship with the therapist with whom you work. Dr Stone: Some of the stuff is the same. Some of the rehabilitation ideas are similar, thinking about boom and bust activity, which is very common in these patients, or grading activity. That's similar, but some of them are really different. So, if you have a patient with a stroke, the physiotherapist might be very used to getting that person to think and look at their leg to try and help them move, which is part of their rehabilitation. In FND, that makes things worse. That's what's happening in Hoover sign and tremor entrainment sign. Attention towards the limb is making it worse. But if the patient's on board with the diagnosis and understands it, they'll also see what you need to do, then, in the physio is actively use distraction in a very transparent way and say to the patient, look, I think if I get you to do that movement, and I'll film you, I think your movement's going to look better. Wouldn't that be great if we could demonstrate that? And the patient says, yeah, that would be great. We're kind of actively using distraction. We're doing things that would seem a bit strange for someone with other forms of movement disorder. So, the patients, for example, with functional gait disorders who you discover can jog quite well on a treadmill. In fact, that's another diagnostic test. Or they can walk backwards, or they can dance or pretend that they're ice skating, and they have much more fluid movements because their ice skating program in their brain is not corrupted, but their normal walking program is. So, can you then turn ice skating or jogging into normal walking? It's not that complicated, I think. The basic ideas are pretty simple, but it does require some creativity from whoever's doing the therapy because you have to use what the patient's into. So, if the patient used to be a dancer- we had a patient who was a, she was really into ballet dancing. Her ballet was great, but her walking was terrible. So, they used ballet to help her walk again. And that's incredibly satisfying for the therapist as well. So, if you have a therapist who's not sure, there are consensus recommendations. There are videos. One really good success often makes a therapist want to do that again and think, oh, that's interesting. I really helped that patient get better. Dr Smith: For a long time, this has been framed as a mental health issue, conversion disorder, and maybe we can talk a little bit about early life of trauma as a risk factor. But, you know, listening to you talk, it sounds like a brain network problem. Even the word “functional”, to me, it seems a little judgmental. I don't know if this is the best term, but is this really a network problem? Dr Stone: The word “functional”, for most neurologists, sounds judgmental because of what you associate it with. If you think about what the word actually is, it's- it does what it says on the tin. There's a disordered brain function. I mean, it's not a great word. It's the least worst term, in my view. And yes, of course it's a brain network problem, because what other organ is it going to be? You know, that's gone wrong? When software brains go wrong, they go wrong in networks. But I think we have to be careful not to swing that pendulum too far to the other side because the problem here, when we say asking the question, is this a mental health problem or a neurological one, we're just asking the wrong question. We're asking a question that makes no sense. However you try and answer that, you're going to get a stupid answer because the question doesn't make sense. We shouldn't have those categories. It's one organ. And what's so fascinating about FND---and I hope what can incite your sort of curiosity about it---is this disorder which defies this categorization. You see some patients with it, they say, oh, they've got a brain network disorder. Then you meet another patient who was sexually abused for five years by their uncle when they were nine, between nine and fourteen; they developed an incredibly strong dissociative threat response into that experience. They have crippling anxiety, PTSD, interpersonal problems, and their FND is sort of somehow a part of that; part of that experience that they've had. So, to ignore that or to deny or dismiss psychological, psychiatric aspects, is just as bad and just as much a mistake as to dismiss the kind of neurological aspects as well. Dr Smith: I wonder if this would be a good time to go back and talk a little bit about a concept that I found really interesting, and that is FND as a prodromal syndrome before a different neurological problem. So, for instance, FND prodromal to Parkinson's disease. Can you talk to us a little bit about that? I mean, obviously I was familiar with the fact that patients who have nonepileptic seizurelike events often have epileptic seizures, but the idea of FND ahead of Parkinson's was new to me. Dr Stone: So, this is definitely a thing that happens. It's interesting because previously, perhaps, if you saw someone who was referred with a functional tremor---this has happened to me and my colleagues. They send me some with a functional tremor. By the time I see them, it's obvious they've got Parkinson's because it's been a little gap. But it turns out that the diagnosis of functional tremor was wrong. It was just that they've developed that in the prodrome of Parkinson's disease. And if you think about it, it's what you'd expect, really, especially with Parkinson's disease. We know people develop anxiety in the prodrome of Parkinson's for ten, fifteen years before it's part of the prodrome. Anxiety is a very strong risk factor for FND, and they're already developing abnormalities in their brain predisposing them to tremor. So, you put those two things together, why wouldn't people get FND? It is interesting to think about how that's the opposite of seizures, because most people with comorbidity of functional seizures and epilepsy, 99% of the time the epilepsy came first. They had the experience of an epileptic seizure, which is frightening, which evokes strong threat response and has somehow then led to a recapitulation of that experience in a functional seizure. So yeah, it's really interesting how these disorders overlap. We're seeing something similar in early MS where, I think, there's a slight excess of functional symptoms; but as the disease progresses, they often become less, actually. Dr Smith: What is the prognosis with the types of physical therapy? And we haven't really talked about psychological therapy, but what's the success rate? And then what's the relapse rate or risk? Dr Stone: Well, it does depend who they're seeing, because I think---as you said---you're finding difficult to get people in your institution who you feel are comfortable with this. Well, that's a real problem. You know, you want your therapists to know about this condition, so that matters. But I think with a team with a multidisciplinary approach, which might include psychological therapy, physio, OT, I think the message is you can get really good outcomes. You don't want to oversell this to patients, because these treatments are not that good yet. You can get spectacular outcomes. And of course, people always show the videos of those. But in published studies, what you're seeing is that most studies of- case series of rehabilitation, people generally improve. And I think it's reasonable to say to a patient, that we have these treatments, there's a good chance it's going to help you. I can't guarantee it's going to help you. It's going to take a lot of work and this is something we have to do together. So, this is not something you're going to do to the patient, they're going to do it with you. Which is why it's so important to find out, hey, do they agree with you with the diagnosis? And check they do. And is it the right time? It's like when someone needs to lose weight or change any sort of behavior that they've just become ingrained. It's not easy to do. So, I don't know if that helps answer the question. Dr Smith: No, that's great. And you actually got right where I was wanting to go next, which is the idea of timing and acceptance. You brought this up earlier on, right? So, sometimes patients are excited and accepting of having an affirmative diagnosis, but sometimes there's some resistance. How do you manage the situation where you're making this diagnosis, but a patient's resistant to it? Maybe they're fixating on a different disease they think they have, or for whatever reason. How do you handle that in terms of initiating therapy of the overall diagnostic process? Dr Stone: We should, you know, respect people's rights to have whatever views they want about what's wrong with them. And I don't see my job as- I'm not there to change everyone's mind, but I think my job is to present the information to them in a kind of neutral way and say, look, here it is. This is what I think. My experience is, if you do that, most people are willing to listen. There are a few who are not, but most people are. And most of the time when it goes wrong, I have to say it's us and not the patients. But I think you do need to find out if they can have some hope. You can't do rehabilitation without hope, really. That's what you're looking for. I sometimes say to patients, where are you at with this? You know, I know this is a really hard thing to get your head around, you've never heard of it before. It's your own brain going wrong. I know that's weird. How much do you agree with it on a scale of naught to ten? Are you ten like completely agreeing, zero definitely don't? I might say, are you about a three? You know, just to make it easy for them to say, no, I really don't agree with you. Patients are often reluctant to tell you exactly what they're thinking. So, make it easy for them to disagree and then see where they're at. If they're about seven, say, that's good. But you know, it'd be great if you were nine or ten because this is going to be hard. It's painful and difficult, and you need to know that you're not damaging your body. Those sort of conversations are helpful. And even more importantly, is it the right time? Because again, if you explore that with people, if a single mother with four kids and, you know, huge debts and- you know, it's going to be very difficult for them to engage with rehab. So, you have to be realistic about whether it's the right time, too; but keep that hope going regardless. Dr Smith: So, Jon, there's so many things I want to talk to you about, but maybe rather than let me drive it, let me ask you, what's the most important thing that our listeners need to know that I haven't asked you about? Dr Stone: Oh God. I think when people come and visit me, they sometimes, let's go and see this guy who does a lot of FND, and surely, it'll be so easy for him, you know? And I think some of the feedback I've had from visitors is, it's been helpful to watch, to see that it's difficult for me too. You know, this is quite hard work. Patients have lots of things to talk about. Often you don't have enough time to do it in. It's a complicated scenario that you're unravelling. So, it's okay if you find it difficult work. Personally, I think it's very rewarding work, and it's worth doing. It's worth spending the time. I think you only need to have a few patients where they've improved. And sometimes that encounter with the neurologist made a huge difference. Think about whether that is worth it. You know, if you do that with five patients and one or two of them have that amazing, really good response, well, that's probably worth it. It's worth getting out of bed in the morning. I think reflecting on, is this something you want to do and put time and effort into, is worthwhile because I recognize it is challenging at times, and that's okay. Dr Smith: That's a great number needed to treat, five or six. Dr Stone: Exactly. I think it's probably less than that, but… Dr Smith: You're being conservative. Dr Stone: I think deliberately pessimistic; but I think it's more like two or three, yeah. Dr Smith: Let me ask one other question. There's so much more for our listeners in the article. This should be required reading, in my opinion. I think that of most Continuum, but this, I really truly mean it. But I think you've probably inspired a lot of listeners, right? What's the next step? We have a general or comprehensive neurologist working in a community practice who's inspired and wants to engage in the proactive care of the FND patients they see. What's the next step or advice you have for them as they embark on this? It strikes me, like- and I think you said this in the article, it's hard work and it's hard to do by yourself. So, what's the advice for someone to kind of get started? Dr Stone: Yeah, find some friends pretty quick. Though, yeah, your own enthusiasm can take you a long way, you know, especially with we've got much better resources than we have. But it can only take you so far. It's really particularly important, I think, to find somebody, a psychiatrist or psychologist, you can share patients with and have help with. In Edinburgh, that's been very important. I've done all this work with the neuropsychiatrist, Alan Carson. It might be difficult to do that, but just find someone, send them an easy patient, talk to them, teach them some of this stuff about how to manage FND. It turns out it's not that different to what they're already doing. You know, the management of functional seizures, for example, is- or episodic functional movement disorders is very close to managing panic disorder in terms of the principles. If you know a bit about that, you can encourage people around you. And then therapists just love seeing these patients. So, yeah, you can build up slowly, but don't- try not to do it all on your own, I would say. There's a risk of burnout there. Dr Smith: Well, Dr Stone, thank you. You don't disappoint. This has really been a fantastic conversation. I really very much appreciate it. Dr Stone: That's great, Gordon. Thanks so much for your time, yeah. Dr Smith: Well, listeners, again, today I've had the great pleasure of interviewing Dr Jon Stone about his article on the multidisciplinary treatment for functional neurologic disorder, which he wrote with Dr Alan Carson. This article appears in the August 2025 Continuum issue on movement disorders. Please be sure to check out Continuum Audio episodes from this and other issues. And listeners, thank you once again for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. We hope you've enjoyed this subscriber-exclusive interview. Thank you for listening.

PeerVoice Clinical Pharmacology Audio
Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Sep 30, 2025 20:23


Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Internal Medicine Audio
Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Internal Medicine Audio

Play Episode Listen Later Sep 30, 2025 20:23


Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Internal Medicine Video
Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Internal Medicine Video

Play Episode Listen Later Sep 30, 2025 20:23


Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Clinical Pharmacology Video
Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

PeerVoice Clinical Pharmacology Video

Play Episode Listen Later Sep 30, 2025 20:23


Jonathan Barratt, PhD, FRCP - The Gut–Kidney Axis and Beyond in IgA Nephropathy: A New Frontier in Precision Therapy

Faculty Factory
Exploring the WISE Framework as a Critical Teaching Guide in Medicine with Farzana Hoque, MD, MRCP, FACP, FRCP

Faculty Factory

Play Episode Listen Later Sep 26, 2025 34:10


We are honored to have Farzana Hoque, MD, MRCP, FACP, FRCP, return to the Faculty Factory Podcast this week. This is her third appearance on the podcast, and this time she joins us to discuss her recently published article in the Journal of Brown Hospital Medicine entitled “WISE Framework: Teaching Guide for Early Career Hospitalists.” The article is based on the WISE Framework, which she formulated and discusses in depth during today's chat. As she notes at the start of the interview, it is applicable to all specialties, not just hospitalists. She currently serves as an Associate Professor of Internal Medicine in the Division of Hospital Medicine at Saint Louis University School of Medicine. She also co-directs the Medicine Sub-Internship at the Saint Louis University School of Medicine. Additionally, she is the Medical Director of Bordley Tower at SSM Health Saint Louis University Hospital. Dr. Hoque's previous two interviews with the Faculty Factory can be found here: Emotional Intelligence (EQ) for Unlocking Leadership Potential: https://facultyfactory.org/eq-leadership/ Embracing Culture Over Strategy: Lessons Learned in Academic Medicine: https://facultyfactory.org/farzana-hoque/ “After several days of thinking, I came up with this WISE framework. W stands for Watchful Observation; I for Insightful Awareness; S for Specific Feedback; and E for Empathic Communication,” she told us. Read Dr. Hoque's recent article in the Journal of Brown Hospital Medicine entitled “WISE Framework: Teaching Guide for Early Career Hospitalists”: https://pubmed.ncbi.nlm.nih.gov/40191700/. You can follow along with her guidance and clinical tips for residents and fellows, and much more by subscribing to her YouTube channel: https://www.youtube.com/@Dr.FarzanaHoque.

The Future of HIV Care
We Hear, They Heal

The Future of HIV Care

Play Episode Listen Later Sep 25, 2025 37:03


This month, we're talking about an infrequently discussed, but quite powerful, implement we have in our clinical toolkit for optimizing patient outcomes: our ears. HIV/sexual health physician, researcher, and author Rageshri Dhairyawan, M.B.B.S., FRCP, joins the pod to talk about the nuances of hearing our patients — i.e., listening to them, understanding and acknowledging their concerns, and incorporating it all into HIV care provision in a way that improves their long-term health and keeps them engaged in care.   Please support us by visiting the episode transcript on TheBodyPro: https://www.thebodypro.com/podcast/hiv/future-hiv-care-listening-patients-rageshri-dhairyawan-sep-2025   Our team: This podcast is hosted by Myles Helfand; our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.  

10,000 Depositions Later Podcast
Episode 161: Unfinished Testimony - Can You Use That Partial Transcript?

10,000 Depositions Later Podcast

Play Episode Listen Later Sep 11, 2025 16:09


Today, Jim Garrity examines a critical issue in trial practice: whether an incomplete deposition—cut short when the deponent becomes unavailable—can be admitted at trial, particularly when the opposing party had no opportunity for cross-examination. Drawing on a new Sixth Circuit Court of Appeals decision and Rule 32 of the Federal Rules of Civil Procedure, Jim explores the court's decision, the key factors trial lawyers should argue for or against exclusion, and the balancing test that should be used when essential testimony hangs in the balance. Discover practical strategies for both offering and opposing use of incomplete deposition transcripts in high-stakes litigation. Thanks for listening!SHOW NOTESInsight Terminal Solutions, LLC v. Cecelia Financial Management, et al., No. 24-5222, 2025 WL 2434894 (6th Cir. August 25, 2025) (reversing trial court's ruling that deposition was categorically inadmissible because defendants did not have an opportunity to cross-examine a 30 B6 deponent before his death)Fed.R.Civ.P. 32(a) (setting three-part test for admissibility of deposition testimony at trial)Treharne v. Callahan, 426 F.2d 58 (3d Cir. 1970) (court upheld the district court's discretionary admission of written interrogatory answers given by the now-deceased defendant, even though the plaintiff could not cross-examine; under Federal Rules of Civil Procedure 26 and 33, answers to interrogatories can be used to the same extent as depositions, which are admissible if the witness is dead; further, the need for the evidence—being the only defense evidence—outweighed the lack of cross-examination, especially where death was not caused by the party offering the evidence and there was no fault involved)Duttle v. Bandler & Kass, 127 F.R.D. 46 (S.D.N.Y. 1989) (magistrate declined to exclude a deposition taken without defense counsel present, even though the witness died before cross-examination could occur; under Rule 32(a), depositions of deceased witnesses may be admitted if the party had notice and opportunity to participate, and the prejudice to the party proffering the deposition (who would lose critical evidence) outweighed potential prejudice to the opponent. Court proposed that any prejudice could be minimized by stipulating to facts the defense might have developed via cross-examination, reducing the impact of any lost impeachment opportunity)Derewecki v. Pennsylvania R. Co., 353 F.2d 436 (3d Cir. 1965) (trial and appeals courts admitted decedent's incomplete depositions as evidence, despite the absence of cross-examination by the defendant who had no chance to cross-examine before the witness died; Rule 26 authorized admission of depositions when the deponent is deceased as long as the circumstances justified it, and both parties had agreed the deposition was “completed” for evidentiary purposes; further, the harm in excluding the sole direct evidence of how the accident occurred outweighed the right to cross-examination. Courts must consider whether the lack of cross is due to fault; here, no such fault was shown)Waterman S. S. Corp. v. Gay Cottons, 414 F.2d 724 (9th Cir. 1969) (deposition of a witness who died before any cross-examination by the adverse party was admitted in bench trial; where there was no realistic possibility that cross-examination would have materially aided the party, exclusion was not required. Further, deposition testimony corroborated by other evidence; thus, lack of cross-examination did not affect the outcome)In re Reingold, 157 F.3d 904 (5th Cir. 1998) (testimony excluded at trial level; exclusion reversed. Trial court excluded party-plaintiff's perpetuation deposition, taken while the plaintiff was gravely ill and ended before cross-examination could be completed due to the witness's declining condition and ultimate death; Fifth Circuit held this exclusion to be a clear abuse of discretion and granted mandamus relief directing admission of the video deposition; FRCP 32(a) creates strong presumption favoring admission of a deceased witness's deposition. Exclusion is only justified by a specific and particularized showing of prejudice, such as stating what crucial areas would have been dealt with in cross-examination; a mere generalized complaint about the lack of cross is insufficient. Since the opposing party had already conducted a substantial deposition of the witness in prior proceedings, the risks of prejudice were further minimized)

Let It In with Guy Lawrence
Doctor REVEALS How Ignoring Spirit Secretly Creates Illness in the Body | Dr Anona Blackwell

Let It In with Guy Lawrence

Play Episode Listen Later Sep 2, 2025 59:54


#373 In this episode, Guy talked with Dr. Anona Blackwell, a respected medical consultant turned mystic. Dr. Blackwell shared her journey from traditional medicine to incorporating spirituality after witnessing unexplained phenomena in her practice. They discussed the integration of mind, body, and spirit in healthcare, the hidden costs of ignoring spiritual aspects in healing, and envisioned a future where science and spirituality coalesce in medical systems. Alongside her intriguing experiences and stories, Dr. Blackwell emphasizes the importance of love, community, and the interconnectedness of health and spirituality. The episode also touched on the potential of AI and energy fields in future medical practices. About Dr. Anona: Dr. Anona Blackwell is an academic physician and avid explorer of the natural world who has dedicated her life to understanding the intricate connections between science and spirituality. Her book, ‘From Medic to Mystic,' is inspired by her personal experiences and a deep-seated curiosity about the universe.  From her humble beginnings as the daughter of a bus driver and market gardener, growing up on a smallholding in rural Wales, Dr. Blackwell, BSc, AKC, FRCP, rose to become a leading authority in genitourinary medicine. She led a research team whose work transformed clinical practice in the UK, improving the health of millions of women by advancing the treatment of anaerobic/ bacterial vaginosis.  Immersed in orthodox medicine by day, she devoted her after-hours to the in-depth investigation of anomalous phenomena, energy healing, and metaphysics. Her innate psychic abilities offered profound insights into her patients' lives, psyches, and hidden traumas—insights that few modern doctors are privileged to experience. Key Points Discussed:  (00:00) - Doctor REVEALS How Ignoring Spirit Secretly Creates Illness in the Body (01:35) - Welsh Roots and Spirituality (02:41) - The Intersection of Medicine and Mysticism (03:28) - Historical Context of Spiritual Healing (05:09) - Personal Experiences with Spiritual Healing (06:04) - The Role of Emotions in Physical Health (06:58) - Medical Career and Spiritual Encounters (20:00) - Early Life and Spiritual Gifts (28:43) - Near-Death Experience and Its Impact (30:46) - Telepathic Awareness and Near-Death Experiences (31:29) - Bridging Worlds: Honoring Spiritual Principles (32:16) - Holistic Healing and Medical Integration (34:36) - Predetermined Life Paths and Free Will (44:18) - Spiritual Healing and Energy Forms (53:21) - The Future of Medicine and Social Connection (57:39) - The Importance of Love and Final Thoughts How to Contact Dr. Anona Blackwell:www.drblackwell.co.uk From Medic to Mystic: The True Story of an Academic Physician's Journey Into the Paranormal   About me:My Instagram: www.instagram.com/guyhlawrence/?hl=en Guy's websites:www.guylawrence.com.au www.liveinflow.co

Law School
Civil Procedure Lecture Forty-Five - Discovery: Tools, Scope, and Obligations

Law School

Play Episode Listen Later Aug 28, 2025 45:23


This conversation provides a comprehensive overview of civil discovery, focusing on the Federal Rules of Civil Procedure (FRCP) and New York state law. It emphasizes the importance of understanding Rule 26 as the foundation of discovery, the concept of proportionality, and the various tools available for gathering information. The discussion also covers the duties of disclosure, the role of expert testimony, and the significance of e-discovery in modern litigation. Key best practices for managing electronically stored information (ESI) and the potential consequences of failing to meet discovery obligations are highlighted, making this a vital resource for law students and practitioners alike.TakeawaysCivil discovery is critical for aspiring lawyers.Rule 26 is the central nervous system of discovery.Proportionality is essential in determining the scope of discovery.Automatic disclosures streamline the discovery process.Expert testimony requires detailed disclosures under Rule 26.The meet and confer process is mandatory and strategic.Depositions and interrogatories are key tools for gathering information.Requests for production must clearly specify ESI needs.Understanding privilege is crucial in discovery.Cost management is vital to avoid excessive litigation expenses.civil discovery, FRCP, e-discovery, legal process, litigation, Rule 26, proportionality, discovery tools, legal obligations, attorney-client privilege

PeerVoice Clinical Pharmacology Audio
Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Aug 27, 2025 18:47


Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Internal Medicine Audio
Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Internal Medicine Audio

Play Episode Listen Later Aug 27, 2025 18:47


Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Clinical Pharmacology Video
Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Clinical Pharmacology Video

Play Episode Listen Later Aug 27, 2025 18:47


Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Internal Medicine Video
Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

PeerVoice Internal Medicine Video

Play Episode Listen Later Aug 27, 2025 18:47


Jonathan Barratt, PhD, FRCP - The Nephrology Journal Club: B-Cell Modulators and eGFR Endpoints in IgA Nephropathy

The Future of HIV Care
A Weighty Conundrum Concluded (and Other IAS 2025 Highlights)

The Future of HIV Care

Play Episode Listen Later Aug 26, 2025 48:58


This month, we're taking stock of clinically noteworthy developments from the IAS Conference on HIV Science in July. On the docket: new (definitive?) data on the relationship between weight gain and ART; a range of studies on ART strategy, including treatment simplification, injectable ART in viremic patients, intermittent oral ART dosing, and PrEP safety in pregnancy; and a glimpse at updated WHO treatment guidelines. We also discuss the general vibe at this year's meeting — and some big news regarding Laura's professional career.   Please support us by visiting the episode transcript (which includes useful context links to relevant studies): https://www.thebodypro.com/podcast/hiv/future-hiv-care-ias-conference-highlights-aug-2025   The pod people: Our co-hosts are Laura Waters, M.D., FRCP, and Myles Helfand; our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.

10,000 Depositions Later Podcast
Episode 159 - Lessons from the Front Lines: Budget-Friendly Depositions: Using a Videographer to Tape & Transcribe Depositions

10,000 Depositions Later Podcast

Play Episode Listen Later Aug 6, 2025 12:41 Transcription Available


Are deposition expenses busting your budget? In this episode, Jim Garrity spotlights a clever strategy conceived by a southern California litigator to sharply cut the costs of deposition transcripts. It's yet another effort by trial lawyers to combat the insane costs of stenographic reporting, and one worth trying. The show notes point to seventeen relevant filings on this issue, four federal rules, and a website for a service that is actively helping lawyers cut deposition costs.Like this podcast? Our production crew LOVES 5-star reviews. They're free, fast to leave, and provide us the kind of appreciative good vibes we crave. Would you mind taking ten seconds and clicking on the five-star rating? Thanks!SHOW NOTES:Note: All filings listed below are from the case Black v. City of San Diego, Case No. 21-cv-1990-RBM-JLB (S.D. Cal. Mar. 27, 2025)Plaintiff's Application For Leave To Conduct Deposition By Video And To Prepare Transcript Using Voice Recognition Technology According To FRCP Rule 30(b)(3)(A) (initial application by Plaintiff) PACER Doc. 153Defendants' Opposition To Plaintiffs Application For Leave To Prepare Deposition Transcript Using Voice Recognition Technology, PACER Doc. 160.Declaration Of Casey Stark In Support Of Plaintiffs Motion For Leave To Conduct Deposition By Video And To Prepare Transcript Using Voice Recognition Technology According To FRCP 30(b)(3)(A), PACER DOC. 153-1Defendant Tutterow's Notice Of Joinder In Defendant City Of San Diego's Opposition To Plaintiffs Ex Parte Application For Leave To Conduct Deposition By Video And Prepare Transcript Using Voice Recognition, PACER Doc. 162.Defendants Supplement To Opposition To Plaintiffs Application For Leave To Prepare Deposition Transcript Using Voice Recognition Technology, PACER Doc. 164Plaintiffs Reply To Opposition To Application For Leave To Conduct Deposition By Video And To Prepare Transcript Using Voice Recognition Technology According To FRCP Rule 30(b)(3)(A), PACER Doc. 165Second Supplemental Declaration Of Casey Stark In Support Of Plaintiff Motion For Leave To Conduct Deposition. Etc., PACER Doc. 170Defendants Second Supplement To Opposition To Plaintiffs Application For Leave To Prepare Deposition Transcript Using Voice Recognition Technology, PACER Doc. 171Order (Magistrate Judge) Denying Plaintiff's Application For Leave To Conduct Deposition By Video And To Prepare Transcript Using Voice Recognition Technology, PACER Doc. 172Plaintiff's Notice Of Objection To Order Denying Application For Leave To Conduct Deposition, Etc. PACER Doc. 173 (appealing magistrate judge's order to district judge)Defendant's Response To Plaintiff's Objection To Magistrate's Order Denying Claims Application For Leave, PACER Doc. 174Plaintiffs Opposition To Defendants Response To Player's Objection To Magistrate's Order Denying Plaintiff's Application, Etc., PACER Doc. 175Order (District Judge) Overruling Plaintiff's Objections, PACER Doc. 178Order Granting Joint Motion For Protective Order, PACER Doc. 32 (providing that certain information was to remain confidential)Modified Protective Order, PACER Doc. 156Readback.legal (reporting agency dedicated to reducing deposition -related costs; interview of Readback's Chief Legal Officer in podcast episode 87)1993 Committee Note to Fed. R. Civ. P. 26 (noting that where a deposition isn't stenographically recorded, transcripts are often later prepared by counsels' own law firmsFed. R. Civ. P. 30(b)(3)(a) (allowing lawyers to capture deposition testimony by stenographic means only, audio only, video only, or any combination of the three)FRCP 26(a)(3)(A)(ii) and FRCP 32(c) (providing that if counsel chooses to record a deposition by video only and plan to present it at trial or hearing, they must provide a transcript of the testimony to the other parties and the court)Readback.legal (innovative and budget-friendly service advertised as "certified, court-admissible deposition service built for legal professionals who need clarity, speed, and accuracy, without relying on outdated stenography")

PeerVoice Clinical Pharmacology Audio
Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Aug 4, 2025 20:45


Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Internal Medicine Audio
Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Internal Medicine Audio

Play Episode Listen Later Aug 4, 2025 20:45


Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Internal Medicine Video
Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Internal Medicine Video

Play Episode Listen Later Aug 4, 2025 20:44


Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Brain & Behaviour Video
Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Brain & Behaviour Video

Play Episode Listen Later Aug 4, 2025 20:44


Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Brain & Behaviour Audio
Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Brain & Behaviour Audio

Play Episode Listen Later Aug 4, 2025 20:45


Saiju Jacob, MD, DPhil, FRCP, FAAN - The Value of Disease Control in gMG: The Latest Data Evaluating Patient Needs and Treatment Outcomes as They Emerge From Helsinki

PeerVoice Oncology & Haematology Video
Alison Birtle, FRCP, FRCR, MD - Case Study Challenge in Advanced Bladder Cancer: Tailoring Treatment to Individual Patients

PeerVoice Oncology & Haematology Video

Play Episode Listen Later Jul 21, 2025 27:46


Alison Birtle, FRCP, FRCR, MD - Case Study Challenge in Advanced Bladder Cancer: Tailoring Treatment to Individual Patients

PeerVoice Oncology & Haematology Audio
Alison Birtle, FRCP, FRCR, MD - Case Study Challenge in Advanced Bladder Cancer: Tailoring Treatment to Individual Patients

PeerVoice Oncology & Haematology Audio

Play Episode Listen Later Jul 21, 2025 27:46


Alison Birtle, FRCP, FRCR, MD - Case Study Challenge in Advanced Bladder Cancer: Tailoring Treatment to Individual Patients

PeerVoice Internal Medicine Audio
Alison Birtle, FRCP, FRCR, MD - Case Study Challenge in Advanced Bladder Cancer: Tailoring Treatment to Individual Patients

PeerVoice Internal Medicine Audio

Play Episode Listen Later Jul 21, 2025 27:46


Alison Birtle, FRCP, FRCR, MD - Case Study Challenge in Advanced Bladder Cancer: Tailoring Treatment to Individual Patients

Be Here Now Network Guest Podcast
Ep. 216 - The Universe Inside You with Deepak Chopra

Be Here Now Network Guest Podcast

Play Episode Listen Later Jul 17, 2025 60:57


Deepak Chopra explores the inner universe and explains how turning inward connects us to God, higher consciousness, and the boundless intelligence of the cosmos.Today's podcast is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/beherenow and get on your way to being your best self.In this deeply intellectual episode, Deepak Chopra holds a lecture on:Three levels of existence: physical, quantum, non-local domainDefining God as the immeasurable potential of all that was, all that is, all that will beHow we are intrinsically connected to the cosmos and universal intelligenceAccessing the wisdom of the universe by turning inwardExperiencing the divine through our own awareness, identity, and perceptionWays we negotiate with the world and looking at the fight-flight response The four control dramas rooted in childhood behavioral conditioningOur innate ability to be in touch with our inner observer—our soul Understanding that consciousness can evolve Freeing ourself from the past, from the known, and not being victimized by our memoriesInvoking Hindu deities like Ganesh for what they symbolize, their knowledge, their energyNumerous levels of God, the creative response, visionary response, sacred response, and beyond“As is the atom, so is the universe. As is the microcosm, so is the macrocosm. As is the human body, so is the cosmic body. As is the human mind, so is the cosmic mind. If something is inside here, it's everywhere. If it's not here, it's nowhere. You, by going inside, can have access to all the knowledge in the whole universe.” – Deepak ChopraThis episode was originally recorded in 2007About Deepak Chopra:Deepak Chopra MD, FACP, FRCP, is a Consciousness Explorer and a world-renowned pioneer in integrative medicine and personal transformation. Dr. Chopra is co-founder of DeepakChopra.ai, his AI twin and well-being advisor. He also co-founded Cyberhuman.ai, a transformative suite of personalized health and well-being solutions. Dr. Chopra is a Clinical Professor of Family Medicine and Public Health at the University of California, San Diego, and serves as a senior scientist with Gallup Organization. He is also an Honorary Fellow in Medicine at the Royal College of Physicians and Surgeons of Glasgow. He is the author of over 95 books, translated into over forty-three languages, including numerous New York Times bestsellers.For the last thirty years, Dr. Chopra has been at the forefront of the meditation revolution. His mission is to create a more balanced, peaceful, joyful and healthier world. Through his teachings, he guides individuals to embrace their inherent strength, wisdom, and potential for personal and societal transformation. In his latest book, Digital Dharma, Dr. Chopra navigates the balance between technology and expanded awareness, explaining that while AI cannot duplicate human intelligence, it can vastly enhance personal and spiritual growth. Learn more about this book and others HERE. “The old paradigm said that human beings are self-contained; we are all independent. But, the new one says that human beings are focal points in one unified field. Unified means everything. Space, time, energy, information, and matter are all part of the field and we are inseparably connected with the pattern of intelligence and the whole cosmos. We are all a web of relationships.” – Deepak ChopraSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Future of HIV Care
HIV Guidelines Under Threat

The Future of HIV Care

Play Episode Listen Later Jul 15, 2025 40:16


  This month, we're diving in deep on the U.S. approval of lenacapavir for PrEP -- both the promise it offers in expanding HIV prevention options and the current uncertainty around access, both in the U.S. and abroad. We also discuss growing concern within the HIV clinical community that our gold-standard guidelines for HIV treatment, care, and prevention may be rousted loose from their long-standing home within the Office of AIDS Research at the U.S. National Institutes of Health. And Laura Waters shares what she's most eager to learn about at IAS 2025, the global HIV science meeting that is taking place as this episode drops.   Please support our podcast by visiting the transcript, which includes links to the many references we mention in this episode: https://www.thebodypro.com/podcast/hiv/future-hiv-care-lenacapavir-prep-guidelines-july-2025   The podfolx: Our co-hosts are Laura Waters, M.D., FRCP, and Myles Helfand; our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.

PedsCrit
Fellowship Project Design with Dr. Mike Spaeder -- Part 2

PedsCrit

Play Episode Listen Later Jul 14, 2025 41:32


Learning Objectives:By the end of this series, listeners should be able to:Understand the research expectations of PICU Fellows in the United States.Explain the types of research available to PICU fellows and how a new fellow might explore their local options. Explain the work necessary to refine a research question and write mature specific aims for a project.  Understand the key factors involved in getting a fellowship paper submitted, including the common pitfalls for each type of research About our Guest: Mike Spaeder is a Professor of Pediatrics at the University of Virginia (UVA) School of Medicine and a pediatric critical care physician at the UVA Children's Hospital in Charlottesville, Virginia. He received his bachelor's degree in mathematics from Trinity College and his master's in statistics from George Washington University, where he also received his medical degree. He completed his pediatrics residency at Hasbro Children's Hospital/Brown University and his pediatric critical care fellowship at the Johns Hopkins Hospital. He is now the director of the Pediatric Critical Care fellowship at the UVA Children's Hospital. His research is based at the Center for Advanced Medical Analytics at the University of Virginia, where he focuses on modeling physiologic signatures of illness to identify patients at risk for clinical deterioration. Selected References:Horvat CM, Hamilton MF, Hall MW, McGuire JK, Mink RB Child Health Needs and the Pediatric Critical Care Medicine Workforce: 2020-2040. Pediatrics 2024 Feb 1 153Tasker RC. Writing for PCCM: The 3,000-Word Structured Clinical Research Report. Pediatr Crit Care Med. 2021 Mar 1;22(3):312-317.Sanchez-Pinto, L. Nelson MD, MBI1; Badke, Colleen M. MD, MS1; Pololi, Linda MBBS, FRCP (hon)2. Group Peer Mentoring: A Strategy to Promote Career Development and Improve Well-Being Among Early-Career Faculty in Pediatric Critical Care Medicine. Pediatric Critical Care Medicine ():10.1097/PCC.0000000000003763, May 15, 2025. | DOI: 10.1097/PCC.0000000000003763 Scott K. Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity. New York: St. Martin's Press; 2017. 1st ed. Equator Guidelines: https://www.equator-network.org/For Authors : Pediatric Critical Care MediQuestions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

PedsCrit
Fellowship Project Design with Dr. Mike Spaeder -- Part 1

PedsCrit

Play Episode Listen Later Jul 7, 2025 34:36


Learning Objectives:By the end of this series, listeners should be able to:Understand the research expectations of PICU Fellows in the United States.Explain the types of research available to PICU fellows and how a new fellow might explore their local options. Explain the work necessary to refine a research question and write mature specific aims for a project.  Understand the key factors involved in getting a fellowship paper submitted, including the common pitfalls for each type of research About our Guest: Mike Spaeder is a Professor of Pediatrics at the University of Virginia (UVA) School of Medicine and a pediatric critical care physician at the UVA Children's Hospital in Charlottesville, Virginia. He received his bachelor's degree in mathematics from Trinity College and his master's in statistics from George Washington University, where he also received his medical degree. He completed his pediatrics residency at Hasbro Children's Hospital/Brown University and his pediatric critical care fellowship at the Johns Hopkins Hospital. He is now the director of the Pediatric Critical Care fellowship at the UVA Children's Hospital. His research is based at the Center for Advanced Medical Analytics at the University of Virginia, where he focuses on modeling physiologic signatures of illness to identify patients at risk for clinical deterioration. Selected References:Horvat CM, Hamilton MF, Hall MW, McGuire JK, Mink RB Child Health Needs and the Pediatric Critical Care Medicine Workforce: 2020-2040. Pediatrics 2024 Feb 1 153Tasker RC. Writing for PCCM: The 3,000-Word Structured Clinical Research Report. Pediatr Crit Care Med. 2021 Mar 1;22(3):312-317.Sanchez-Pinto, L. Nelson MD, MBI1; Badke, Colleen M. MD, MS1; Pololi, Linda MBBS, FRCP (hon)2. Group Peer Mentoring: A Strategy to Promote Career Development and Improve Well-Being Among Early-Career Faculty in Pediatric Critical Care Medicine. Pediatric Critical Care Medicine ():10.1097/PCC.0000000000003763, May 15, 2025. | DOI: 10.1097/PCC.0000000000003763 Scott K. Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity. New York: St. Martin's Press; 2017. 1st ed. Equator Guidelines: https://www.equator-network.org/For Authors : Pediatric Critical Care MediQuestions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

PeerVoice Clinical Pharmacology Audio
Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Jul 7, 2025 27:30


Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Clinical Pharmacology Audio
Liz Lightstone, MBBS (Hons), PhD, FRCP - Preventing Flare and Protecting Function: What Progress Is Being Made in Active Lupus Nephritis?

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Jul 7, 2025 50:18


Liz Lightstone, MBBS (Hons), PhD, FRCP - Preventing Flare and Protecting Function: What Progress Is Being Made in Active Lupus Nephritis?

PeerVoice Oncology & Haematology Video
Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Oncology & Haematology Video

Play Episode Listen Later Jul 7, 2025 27:30


Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Oncology & Haematology Audio
Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Oncology & Haematology Audio

Play Episode Listen Later Jul 7, 2025 27:30


Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Internal Medicine Audio
Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Internal Medicine Audio

Play Episode Listen Later Jul 7, 2025 27:30


Adam Brufsky, MD, PhD / Rebecca Dent, MD, FRCP (Canada) - Same Class, Different Agents: Practical Considerations for Managing Toxicities of Interest in Patients on TROP2-Directed Therapies in Breast Cancer

PeerVoice Internal Medicine Audio
Liz Lightstone, MBBS (Hons), PhD, FRCP - Preventing Flare and Protecting Function: What Progress Is Being Made in Active Lupus Nephritis?

PeerVoice Internal Medicine Audio

Play Episode Listen Later Jul 7, 2025 50:18


Liz Lightstone, MBBS (Hons), PhD, FRCP - Preventing Flare and Protecting Function: What Progress Is Being Made in Active Lupus Nephritis?

PeerVoice Clinical Pharmacology Audio
Marianna Fontana, MD, PhD / Julian Gillmore, MD, PhD, FRCP, FRCPath - Identifying Outcomes That Matter in ATTR-CM: Critical Considerations in the Interpretation of Contemporary Clinical Trials

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Jun 30, 2025 31:29


Marianna Fontana, MD, PhD / Julian Gillmore, MD, PhD, FRCP, FRCPath - Identifying Outcomes That Matter in ATTR-CM: Critical Considerations in the Interpretation of Contemporary Clinical Trials

PeerVoice Heart & Lung Audio
Marianna Fontana, MD, PhD / Julian Gillmore, MD, PhD, FRCP, FRCPath - Identifying Outcomes That Matter in ATTR-CM: Critical Considerations in the Interpretation of Contemporary Clinical Trials

PeerVoice Heart & Lung Audio

Play Episode Listen Later Jun 30, 2025 31:29


Marianna Fontana, MD, PhD / Julian Gillmore, MD, PhD, FRCP, FRCPath - Identifying Outcomes That Matter in ATTR-CM: Critical Considerations in the Interpretation of Contemporary Clinical Trials

PeerVoice Internal Medicine Audio
Marianna Fontana, MD, PhD / Julian Gillmore, MD, PhD, FRCP, FRCPath - Identifying Outcomes That Matter in ATTR-CM: Critical Considerations in the Interpretation of Contemporary Clinical Trials

PeerVoice Internal Medicine Audio

Play Episode Listen Later Jun 30, 2025 31:29


Marianna Fontana, MD, PhD / Julian Gillmore, MD, PhD, FRCP, FRCPath - Identifying Outcomes That Matter in ATTR-CM: Critical Considerations in the Interpretation of Contemporary Clinical Trials

See You Now
123: Safer Together | The Architecture of a Movement

See You Now

Play Episode Listen Later Jun 27, 2025 53:47


Despite decades of effort and innovation since the groundbreaking To Err is Human report over 25 years ago, preventable harm in healthcare persists, and violence against healthcare workers continues to rise. With record understaffing, burnout, mandatory overtime, and mounting documentation demands, the pressure to provide safe care has never been higher nor the stakes more urgent. In this first episode of our new series focusing on safety in healthcare, we explore a bold shift toward "total systems safety" with two leaders at the forefront of this movement who know these challenges all too well. Patricia McGaffigan, RN, MS, CPPS, Senior Advisor for Patient and Workforce Safety at the Institute for Healthcare Improvement, and President of the Certification Board for Professionals in Patient Safety, and Donald Berwick, MD, MPP, FRCP, President Emeritus and Senior Fellow at the Institute for Healthcare Improvement, and former Administrator of the Centers for Medicare and Medicaid Services. Together, they continue to shape national safety efforts including IHI's Safer Together: National Action Plan to Advance Patient Safety the first public-private collaboration of its kind. Spearheaded by McGaffigan and bringing together 27 major organizations that had never collaborated before. The plan aims to restructure the very foundation of healthcare, building safety into every level of the system around four interlocking pillars. Leadership & Governance: Strong, visible leadership and policies that make safety a strategic priority. Workforce Safety & Well-Being: Protecting nurses and healthcare workers – physically and mentally – so they can care safely for others. Patient & Family Engagement: Partnering with patients and family caregivers as co-designers of safe care. Learning Systems: Creating feedback loops and continuous improvement so lessons from one hospital spread everywhere.   At the heart of this movement is a truth long understood by nurses: safety is not a checklist or a policy, it's a culture, a commitment, and a collective responsibility. As Patricia McGaffigan reminds us, “You can't have patient safety if you don't have a safe workforce.” And as Don Berwick warns, “The illusion that safety is a matter of individual effort is one of the most toxic notions in the whole safety enterprise. It is we, not me.” Nurses have always led by example, holding space for healing while navigating broken systems. Now, their leadership is essential in building the future of healthcare safety: one that protects not only patients, but the people who care for them. Where healthcare is not only safer, but also is a culture that ensures we're all Safer Together.

CCO Infectious Disease Podcast
Partnering With Patients for PBC Care: Actionable Strategies for HCPs

CCO Infectious Disease Podcast

Play Episode Listen Later Jun 26, 2025 13:45


In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including:Disease concerns and frequently asked questions from a patient perspectiveManaging symptomsTreatment options and supportive careImportance of awareness and educationPresenters:Gideon Hirschfield, MA, MB BChir, FRCP, PhDLily and Terry Horner Chair in Autoimmune Liver Disease ResearchProfessor, Division of Gastroenterology and HepatologyUniversity of TorontoDirector, The Autoimmune and Rare Liver Disease ProgrammeDirector, Francis Family Liver ClinicToronto General Hospital, University Health NetworkOntario, CanadaJess N. Schnur, BSN-RNNational PBC Patient AdvocateAmerican Liver FoundationDonation Support Services CoordinatorLifeline of OhioColumbus, OhioTo learn more, see the programHear Me: Patient Perspectives on PBC

The Future of HIV Care
Wonderful Bad News

The Future of HIV Care

Play Episode Listen Later Jun 23, 2025 38:02


This month, we're digging into some recent, clinically notable HIV research in the U.S. that leaves us seeing a complex mix of clouds and silver (or perhaps gold?) linings. Specifically: new findings on ART prescription practices; a study on barriers to rapid HIV treatment initiation; and state-level data on PrEP prescribing trends relative to HIV diagnoses.   Support us by visiting the online transcript: https://www.thebodypro.com/podcast/hiv/future-hiv-care-clouds-silver-linings-june-2025   And watch this touching video from Oslo Pride on the importance of symbols: https://www.youtube.com/watch?v=UVepoXddTW4   The pod production team: Our co-hosts are Laura Waters, M.D., FRCP, and Myles Helfand; our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.

PeerVoice Oncology & Haematology Video
Peter Schmid, FRCP, MD, PhD - Use of Neoadjuvant Chemoimmunotherapy Followed by Adjuvant Immunotherapy in Early-Stage TNBC: A Case-Based Discussion

PeerVoice Oncology & Haematology Video

Play Episode Listen Later Jun 23, 2025 13:39


Peter Schmid, FRCP, MD, PhD - Use of Neoadjuvant Chemoimmunotherapy Followed by Adjuvant Immunotherapy in Early-Stage TNBC: A Case-Based Discussion

PeerVoice Clinical Pharmacology Audio
Richard David Graham Leslie, MD, FRCP, FAoP - When Could Dysglycaemia in Adults Be Type 1 Diabetes? Expert Perspectives on Recognising and Addressing Diagnostic Complexities and Challenges

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later May 30, 2025 19:46


Richard David Graham Leslie, MD, FRCP, FAoP - When Could Dysglycaemia in Adults Be Type 1 Diabetes? Expert Perspectives on Recognising and Addressing Diagnostic Complexities and Challenges

PeerVoice Endocrinology & Metabolic Disorders Video
Richard David Graham Leslie, MD, FRCP, FAoP - When Could Dysglycaemia in Adults Be Type 1 Diabetes? Expert Perspectives on Recognising and Addressing Diagnostic Complexities and Challenges

PeerVoice Endocrinology & Metabolic Disorders Video

Play Episode Listen Later May 30, 2025 19:46


Richard David Graham Leslie, MD, FRCP, FAoP - When Could Dysglycaemia in Adults Be Type 1 Diabetes? Expert Perspectives on Recognising and Addressing Diagnostic Complexities and Challenges

The Future of HIV Care
Can the British Be Our HIV Backup?

The Future of HIV Care

Play Episode Listen Later May 20, 2025 40:04


In a time of growing uncertainty for the HIV response within the U.S., you may be wondering: What do I do if the public guidelines and resources I rely on to provide HIV-related clinical services cease receiving updates or are permanently removed? Laura and Myles discuss the complexities of our current moment -- and the extent to which our colleagues across the pond in the British HIV Association (BHIVA) can help fill the gap. Laura will also review recent highlights from BHIVA's annual Spring Conference, a cross-disciplinary meeting featuring clinical research and state-of-the-art updates. ° Read the full transcript, which includes a bevy of relevant links: https://www.thebodypro.com/podcast/hiv/future-hiv-care-bhiva-may-2025 ° The pod production team: Our co-hosts are Laura Waters, M.D., FRCP, and Myles Helfand; our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.

The Past Lives Podcast
A Doctor's Supernatural Experiences

The Past Lives Podcast

Play Episode Listen Later May 14, 2025 11:12


Chronicling her dual professional life as a highly respected, Lancet-published academic physician while also investigating powerful psychic and paranormal experiences in her work and personal life, Dr. Blackwell presents compelling evidence for telepathy, clairvoyance, near-death experiences (NDEs), life after death, the power of prayer, non-ordinary reality, and more.The book reveals how, after years of attempting to reconcile her extraordinary experiences, Dr. Blackwell transformed from a scientifically trained medic into a mystic, acknowledging there is far more to life - and to us - than science alone can explain. Her irreverent sense of humour (her account of meeting Prince Charles is unmissable) and her ability to integrate both orthodox and complementary medical practices create a thought-provoking, multi-layered, and often amusing read.By sharing her forays into non-ordinary reality, Dr. Blackwell encourages others to share their paranormal experiences without fear of being labelled ‘crazy'.BioFrom humble beginnings as the daughter of a bus driver and market gardener, growing up on a smallholding in rural Wales, Dr. Blackwell, BSc, AKC, FRCP, rose to become a leading authority in genito-urinary medicine. Immersed in orthodox medicine by day, she devoted her after-hours to the in-depth investigation of anomalous phenomena, energy healing, and metaphysics. Her innate psychic abilities offered profound insights into her patients' lives, psyches, and hidden traumas – insights that few modern doctors are privileged to experience.A passionate explorer of the natural world, with a deep-rooted interest in organic gardening, sustainable living and the mysteries of the cosmos, with years of experience in both scientific research and metaphysical studies, Dr. Blackwell shares her unique perspectives and knowledge through engaging blog posts. Her mission is to inspire others to appreciate the wonders of our universe, from the soil beneath our feet to the stars above. You can read more fascinating stories about her own and others' experiences at Dr Blackwell's website, where she encourages those who have had similar experiences to share them with her audience.https://www.amazon.com/dp/B0DV9KZSY5https://www.drblackwell.co.uk/ https://www.pastliveshypnosis.co.uk/https://www.patreon.com/ourparanormalafterlifeMy book 'Verified Near Death Experiences' https://www.amazon.com/dp/B0DXKRGDFP

The Past Lives Podcast
A Physician's Journey Into the Paranormal

The Past Lives Podcast

Play Episode Listen Later May 12, 2025 55:50


Chronicling her dual professional life as a highly respected, Lancet-published academic physician while also investigating powerful psychic and paranormal experiences in her work and personal life, Dr. Blackwell presents compelling evidence for telepathy, clairvoyance, near-death experiences (NDEs), life after death, the power of prayer, non-ordinary reality, and more.The book reveals how, after years of attempting to reconcile her extraordinary experiences, Dr. Blackwell transformed from a scientifically trained medic into a mystic, acknowledging there is far more to life - and to us - than science alone can explain. Her irreverent sense of humour (her account of meeting Prince Charles is unmissable) and her ability to integrate both orthodox and complementary medical practices create a thought-provoking, multi-layered, and often amusing read.By sharing her forays into non-ordinary reality, Dr. Blackwell encourages others to share their paranormal experiences without fear of being labelled ‘crazy'.BioFrom humble beginnings as the daughter of a bus driver and market gardener, growing up on a smallholding in rural Wales, Dr. Blackwell, BSc, AKC, FRCP, rose to become a leading authority in genito-urinary medicine. Immersed in orthodox medicine by day, she devoted her after-hours to the in-depth investigation of anomalous phenomena, energy healing, and metaphysics. Her innate psychic abilities offered profound insights into her patients' lives, psyches, and hidden traumas – insights that few modern doctors are privileged to experience.A passionate explorer of the natural world, with a deep-rooted interest in organic gardening, sustainable living and the mysteries of the cosmos, with years of experience in both scientific research and metaphysical studies, Dr. Blackwell shares her unique perspectives and knowledge through engaging blog posts. Her mission is to inspire others to appreciate the wonders of our universe, from the soil beneath our feet to the stars above. You can read more fascinating stories about her own and others' experiences at Dr Blackwell's website, where she encourages those who have had similar experiences to share them with her audience.https://www.amazon.com/dp/B0DV9KZSY5https://www.drblackwell.co.uk/ https://www.pastliveshypnosis.co.uk/https://www.patreon.com/ourparanormalafterlifeMy book 'Verified Near Death Experiences' https://www.amazon.com/dp/B0DXKRGDFP

The Future of HIV Care
In HIV Care, the Nuances Matter

The Future of HIV Care

Play Episode Listen Later Apr 29, 2025 37:11


Myles Helfand and Laura Waters, M.D., FRCP, discuss recently published, clinically noteworthy findings from a trio of venerable HIV cohort studies. First, they review new data from the ATHENA study on non-AIDS events among so-called "HIV controllers." They then move on to recent findings from the START study regarding the link between ART initiation timing and cardiovascular disease risk. Finally, they explore new REPRIEVE data exploring the impact (or lack thereof) of statin use on non-cardiovascular events. ‡ Read (and share!) the full transcript: https://www.thebodypro.com/hiv/future-hiv-care-nuances-matter-april-2025 ‡ The pod production team: Our senior production manager is Alina Mogollon-Volk; our senior producer is Lizzie Warren; our associate production manager is Maui Voskova; our audio editor is Kim Buikema; and our executive producer is Myles Helfand.

CCO Infectious Disease Podcast
Key HIV Studies Influencing My Practice Following CROI 2025—Dr Chloe Orkin and Dr Jean-Michele Molina

CCO Infectious Disease Podcast

Play Episode Listen Later Apr 4, 2025 39:03


In this episode, Chloe Orkin, MBChB, FRCP, MD, and Jean-Michel Molina, MD, PhD, discuss highlights from CCO's independent conference coverage of CROI 2025, including:Advances in HIV treatment based on results from CARESPotential HIV therapies in the pipeline, such as doravirine/islatravirEffects of broadly neutralizing antibodies on HIV treatment and cure Key clinical data on HIV and STI prevention obtained from PILLAR, HPTN 083, PURPOSE 1, and STOMPPresenters:Chloe Orkin, MBChB, FRCP, MDProfessor of Infection and InequitiesDean for Healthcare TransformationHonorary Consultant Physician, Barts Health NHS TrustFaculty of Medicine and DentistryQueen Mary University of LondonLondon, United KingdomJean-Michel Molina, MD, PhDProfessor of MedicineUniversity of Paris CiteDepartment of Infectious DiseasesSaint-Louis and Lariboisiere Hospitals, APHPParis, FranceLink to full program:bit.ly/3E1bAYQTo access all of our new podcast episodes, subscribe to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. 

Answers from the Lab
Liquid Biopsy Enables Precision Cancer Care: Bill Morice, M.D., Ph.D.

Answers from the Lab

Play Episode Listen Later Apr 3, 2025 11:09


In this episode of “Answers From the Lab,” William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, invited Min-Han Tan, M.B.B.S., FRCP, Ph.D., founding CEO and medical director of Lucence, to discuss liquid biopsy cancer testing. Mayo Clinic Laboratories and Lucence recently announced a collaboration to expand access to this cutting-edge cancer test that is designed to detect clinically relevant biomarkers in ctDNA and ctRNA.During their conversation, Dr. Morice and Dr. Tan explore:Inspiration for developing the liquid biopsy.Features that differentiate LiquidHALLMARK® from existing cancer tests.Patients who will benefit from the test and how an oncologist might use the results.The future potential of liquid biopsy advancements.

10,000 Depositions Later Podcast
Episode 151 - Lessons from the Front Lines: Using Deposition Transcripts From One Case as Affidavits in Others

10,000 Depositions Later Podcast

Play Episode Listen Later Mar 4, 2025 10:40


In this episode, Jim Garrity spotlights a new ruling on a little-known but powerful tool: the use of depositions as affidavits. As Garrity discusses, a deposition does not need to meet the requirements of trial-oriented Fed. R. Civ. P. 32 (which requires a showing that the party against whom the deposition is offered had notice and a chance to examine the deposition) when it is offered in proceedings that allow testimony by affidavit, such as at summary judgment.SHOW NOTESSurety v. Co. v. Dwight A. Herald, et al., Case No. 1:23-cv-00086-GNS-HBB, 2025 WL 627523 (W.D. Ky. Feb. 26, 2025) (deposition/examination under oath of witness taken in underlying state-court personal injury could be used in federal declaratory judgment actions at summary judgment time, as deposition meets form of affidavit)Diamonds Plus, Inc. v. Kolber, et al., 960 F. 2d 765 (8th Cir. 1992) (deposition need not be admissible at trial to be properly considered in opposition to motions for summary judgment; deposition inadmissible at trial because one of the defendants did not receive proper notice and did not attend the deposition was properly used to create issues of fact justifying denial of summary judgment)Hoover v. Switlik Parachute Co., 663 F.2d 964, 966-67 (9th Cir. 1981) (“Rule 56 ... plainly allows consideration of “affidavits” and we find nothing which requires that term to be construed within the limitations of Rule 32(a).”).First Gaston Bank of North Carolina v. City of Hickory, 691 S.E.2d 715 (Ct. App. N.C. 2010) (citing cases rejecting proposition that FRCP 32 limits use of depositions in proceedings where evidence in affidavit form is admissible; pointing out that to the extent a party objects that they didn't have an opportunity to cross-examine a witness whose deposition from some other cases being offered, “the same objection can frequently be made as to affidavits filed in connection with motions for summary judgment”)Tingey v. Radionics, 193 F. App'x 747, 765–66 (10th Cir. 2006) (reversing summary judgment where trial court, relying on FRCP 32, excluded from consideration in opposition to summary judgment a deposition that plaintiff took of physician in separate state proceeding, where defendant was not party to that proceeding and had not been given notice of deposition; depositions can be used as affidavits in proceedings where affidavits are admissible; to illustrate, “[p]arties may file affidavits in support of summary judgment without providing notice or an opportunity to cross-examine the affiant. See Fed.R.Civ.P. 56(c). The “remedy” for this non-confronted affidavit testimony is to file an opposing affidavit, not to complain that one was not present and permitted to cross-examine when the affidavit was signed. For this reason, the Ninth Circuit has permitted a party to introduce deposition testimony for summary judgment purposes against a party who was not present at the deposition, by construing the deposition as an affidavit. Hoover v. Switlik Parachute Co., 663 F.2d 964, 966–67 (9th Cir.1981)”)Nippon Credit Bank, Ltd. v. Matthews, 291 F.3d 738, 751 (11th Cir. 2002) (without analyzing scope and extent of application of FRCP 32, court broadly said that “Depositions are generally admissible provided that the party against whom they are admitted was present, represented, or reasonably noticed, Fed.R.Civ.P. 32(a), and are specifically allowed in consideration of summary judgment. Fed.R.Civ.P. 56(c). A deposition taken in a different proceeding is admissible if the party against whom it is offered was provided with an opportunity to examine the deponent. Fed.R.Evid. 804(b)(1).”)Fed. R. Civ. P. 56(c)(1)(A) (explicitly allowing citation to depositions for or against summary judgment)8 Charles Alan Wright & Arthur R. Miller, Federal Practice and Procedure § 2142 (1970))) (as are at least as good as affidavits and should be usable whenever an affidavit would be permissible, even where the conditions or requirements for use at trial under rule 32 are not met)