Podcasts about sirp

"Sa sünnid ja sured selle kultuuritöötaja miinimumpalga peal, ükskõik, kui palju sa end aastatega harid ja töökogemuste võrra paremaks saad. Ja kultuurivaldkonnas ollakse sellega leppinud," kahetseb nädalalehe Sirp peatoimetaja Kaarel Tarand.

ALİ KOÇ'UN DÜŞÜRÜLÜŞÜ： KONUŞULMAYAN HESAP #alikoç #goztepe #dilanpolat Ali Koç'un düşürülüşünde konuşulmayanlar. Göztepe Kulübünün gizemli SIRP sahibi. Ali Koç'un Devlet Bahçeli ziyaretinin şifreleri, Bahçeli'nin çok güçlü mesajları. Federasyon ve İbrahim Hacıosmanoğlu cephesinde olanlar. Dilan Polat'ın serbest bırakılmasının ayrıntıları. Ümit Günay'ın tahliye gedilişi, Osman Gökçek cephesinde dönen milyon dolarlar. Bahçeli'nin 17 25 Aralık Saatini yeniden ortaya çıkarmasının detayları.

Robert Towarnicki, CEO and Co-founder of SIRPant Immunotherapeutics, discusses cancer-specific immunotherapy for aggressive tumors, the role macrophages play in the immune response to cancer, and how cancer cells can shut down this response. SIRPant Immunotherapeutics aims to modify macrophages by reducing SIRPα expression, triggering them to eat cancer cells and educate other immune cells. Early evidence demonstrates potential effectiveness for various cancers, including non-Hodgkin's lymphoma and solid tumors. Robert emphasizes this therapy's scalability and cost advantages compared to other cell therapies like CAR-T. He also highlights the potential for treating rare diseases and the ability of SIRPant-M to target a wide range of cancers without the need for pre-identified targets. Robert explains, "Macrophages are a normal immune cell type in your body. They normally function to recognize foreign invaders and process them in the sense of phagocytizing or eating the foreign protein and invader, if it's a virus, a bacteria, or a cancer. Unfortunately, cancers are very good at shutting down this immune response. So, we need to modify the macrophage and re-empower it to elicit the other immune cells in the body to do their job and eliminate cancer." "I think one of the mistakes we've seen with others working with the macrophage in this situation was the lack of appreciation for the role of SIRPα. Our inventor, Dr. Yuan Liu at Georgia State University, identified this early on through a knockout mouse, a mouse where SIRPα was genetically removed from it. With that mouse, she could discover and learn how macrophages function and react. It directed us to the whole concept of removing SIRPα from the macrophage. Now, removal alone is not enough. You also have to activate a macrophage. So, a macrophage exists in multiple states. There's an active state, and then there's an inactive state." #SIRPant #Immunotherapy #Macrophages #Oncology #Cancer sirpantimmunotx.com Download the transcript here

Robert Towarnicki, CEO and Co-founder of SIRPant Immunotherapeutics, discusses cancer-specific immunotherapy for aggressive tumors, the role macrophages play in the immune response to cancer, and how cancer cells can shut down this response. SIRPant Immunotherapeutics aims to modify macrophages by reducing SIRPα expression, triggering them to eat cancer cells and educate other immune cells. Early evidence demonstrates potential effectiveness for various cancers, including non-Hodgkin's lymphoma and solid tumors. Robert emphasizes this therapy's scalability and cost advantages compared to other cell therapies like CAR-T. He also highlights the potential for treating rare diseases and the ability of SIRPant-M to target a wide range of cancers without the need for pre-identified targets. Robert explains, "Macrophages are a normal immune cell type in your body. They normally function to recognize foreign invaders and process them in the sense of phagocytizing or eating the foreign protein and invader, if it's a virus, a bacteria, or a cancer. Unfortunately, cancers are very good at shutting down this immune response. So, we need to modify the macrophage and re-empower it to elicit the other immune cells in the body to do their job and eliminate cancer." "I think one of the mistakes we've seen with others working with the macrophage in this situation was the lack of appreciation for the role of SIRPα. Our inventor, Dr. Yuan Liu at Georgia State University, identified this early on through a knockout mouse, a mouse where SIRPα was genetically removed from it. With that mouse, she could discover and learn how macrophages function and react. It directed us to the whole concept of removing SIRPα from the macrophage. Now, removal alone is not enough. You also have to activate a macrophage. So, a macrophage exists in multiple states. There's an active state, and then there's an inactive state." #SIRPant #Immunotherapy #Macrophages #Oncology #Cancer sirpantimmunotx.com  Listen to the podcast here

Free course ChatGPT4 in medical writing and editing at learnAMAstyle.com ·       Nascentmc.com for medical writing assistance for your company.Visit nascentmc.com/podcast for full show notes Boxed Warning for CAR-T Cell Therapy: The FDA mandates a boxed warning on all CAR T-cell therapies due to increased secondary cancer risks, affecting six named treatments. This follows investigations into T-cell malignancies in patients treated with BCMA- or CD19-directed therapies. Manufacturers have 30 days to comply or challenge this requirement, reflecting the FDA's stance that benefits still outweigh risks.  Dupilumab for Pediatric EOE: The FDA has approved dupilumab for children aged 1-11 with eosinophilic esophagitis (EoE), expanding from its prior approval for older patients. Dupilumab, targeting interleukin-4 and -13, treats EoE, an allergic inflammation causing symptoms like heartburn and difficulty swallowing. The approval, based on the EoE KIDS trial, marks the first FDA-approved EoE treatment for this age group.  Wearable Device for Osteopenia: The FDA has cleared Osteoboost, a wearable belt for treating osteopenia, marking a non-drug medical device approach in this field. Developed by Bone Health Technologies, it uses low-intensity vibrations on the spine and hip, inspired by NASA's bone loss prevention methods. Clinical trials show its effectiveness in maintaining bone health, and it was reviewed under the FDA's De Novo process with Breakthrough Device Designation.  BSI-082 IND for Solid and Liquid Tumors: The FDA approved an IND application for BSI-082, a novel antibody targeting SIRPα and β to enhance tumor-associated macrophages' phagocytic activity. Developed by Biosion USA, Inc., BSI-082 covers over 90% of human populations and avoids broad toxicity typical in CD47-targeting therapies. Its in vivo efficacy, especially when combined with other antibodies, shows significant anti-tumor effects in animal models. VCA-894A for Charcot Marie-Tooth: The FDA approved an IND application for VCA-894A by Vanda Pharmaceuticals to treat Charcot-Marie-Tooth disease, axonal, type 2S (CMT2S). VCA-894A, an antisense oligonucleotide, targets the IGHMBP2 gene variant responsible for CMT2S. CMT2S, a rare condition with symptoms like muscle weakness and sensory impairment, currently has no available treatments; this approval represents a significant step in addressing this genetic disorder. Free course on ChatGPT4 for medical writers and editors learnAMAstyle.com

In this podcast episode, the host Rodney Smith aka Lord Petty, discusses a variety of controversial topics. To view video episode please visit this YouTube Link He shares his views on climate protesters, the concept of oppression in America, and the reasons why Asians are good at math. Rodney also touches on the cultural and political tensions between various groups, including the Israel-Palestine conflict. He criticizes those who are easily offended and asserts that nobody is truly oppressed in the U.S. The podcast is a mix of humor, personal anecdotes, and social commentary, aiming to challenge mainstream narratives. Find all Rodney's social and product links here https://linktr.ee/rodneywrites   In this episode of "Dangerous Misinformation," host Rodney Smith dives into a range of controversial topics with his trademark candidness and irreverent humor. He starts by discussing a video he saw of climate protesters attempting to stop a bus, expressing his skepticism about their methods and the effectiveness of their activism. Rodney goes on to touch upon sensitive subjects such as race, privilege, and oppression, challenging common narratives and societal norms. He questions the need for people to be offended by words, emphasizing his belief that being offended should not hold such significance in today's world. Rodney also delves into the issue of athletes being identified by their last names and questions the tradition, humorously pondering why some individuals can't just be known by their first names. Throughout the episode, Rodney's raw and unfiltered perspective shines, urging listeners to question societal conventions and think critically about the issues discussed. While his opinions are controversial and provocative, Rodney encourages listeners to share the podcast, spreading what he humorously labels as "dangerous misinformation" to challenge mainstream thinking. The episode combines humor, sarcasm, and blunt honesty, making it a unique and thought-provoking listen for those who appreciate unfiltered commentary on various social and cultural topics.   Transcription: 1 00:00:00,200 --> 00:00:16,980 Greetings everybody, thank you for joining us on dangerous misinformation. Tune in. Today's we'll be talking about pressing topics such as climate protesters, sensitive people, why Asians are good at math and much, much, much more fun for the entire family. Appreciate you being here. Let's get into it.  2 00:00:28,000 --> 00:01:01,480 Greetings everybody. Welcome welcome welcome it is Friday. You've made it you've made it through an entire week without doing the dark thoughts on your mind. The dark thoughts. Maybe you did do some dark thoughts, if you did do some dark thoughts, tell me about it. I want to hear about it, and when I say dark thoughts I'm talking about crack and black girls. Welcome to Dangerous Misinformation, the number one source on the worldwide webs for dangerous misinformation. This is formerly known as the Lord Petty Podcast and you are here  3 00:01:01,480 --> 00:01:02,460 because  4 00:01:02,640 --> 00:02:01,060 the wonders of the world, the workings, the eternal energies of lifes brought you here and we are now forever mingled together. There's no going back. This is what it is this is what destiny's had in store for us. Please be sure to tell somebody about the podcast if you are a returning petty person, or if this is your first time tuning in I want to welcome you with open pasty Deutsch arms. I really appreciate you being here. Hopefully we can fill your day, brighten your day with some dangerous misinformation, teach you some things you may not know. Make your truckle a little bit nor for all just grow together and move through space and time. Zoo zombie, and if you don't know what zoo zombie means, it was a very a homosexual sounding way of saying the word tuzamin, which means together in German. How funny is that that tuzamin? That sounds like you know a medieval torture device or something like that, but it means together.  5 00:02:02,080 --> 00:02:19,580 So yeah, thank you for tuning in my name is Rodney Smith, your humble narrator, and let's dive into it. I saw a video this morning, right? There's a video going around of this bus which it looks like the bus is heading back to the UK carrying migrants or something like that probably, but I don't know. Maybe I'm just being racist  6 00:02:19,960 --> 00:02:20,820 and  7 00:02:21,000 --> 00:02:51,080 but the thing is, you see all these just you know, pussy granola, liberal white people standing in front of the bus trying to stop the bus from going and so what these people are are climate protesters? Okay, and the thing about climate protesters is they are a really, really, really bad image for the fact of climate change. I'm not even denying climate change. Okay, I'm not educated on the subject enough to even debate with it I'm gonna put my chips with the guys who are actual scientists.  8 00:02:51,080 --> 00:02:51,880 Okay,  9 00:02:52,720 --> 00:03:23,620 the Republicans like to call everything a conspiracy theory and there's a lot of mainstream conspiracy theories, but as you know, shit like the flat Earth or that. Humans have no impact on the world at all and low, low, low I don't know. I get kind of like weird, scared like I'm going to trust the people with the science degrees who study the Earth for a living more than I'm going to trust the people who have invested interest in oil. You know what I mean and I don't want an electric car. Don't get me wrong. I don't want it. I don't want it. I don't like electric cars.  10 00:03:24,160 --> 00:03:28,600 I want to step on a gas and hear that big rumble, but  11 00:03:28,840 --> 00:03:59,240 these climate protesters did. They make me want to go out and buy a diesel F 3. 50 and roll call because they just make me want the planet to be engulfed and smoke. They're just such a bad face for climate change. And how is it? Because here's where it gets me kind of skeptical? How is it the climate change is this thing where it's hard for me to really reject it? But then when I look at the people who are most involved with them like these people are fucking morons, they're standing, they're going  12 00:03:59,240 --> 00:04:00,560 stop,  13 00:04:00,560 --> 00:04:21,240 stop standing in front of this bus trying to stop cars with their hands like do they not realize that a fucking car can tow a boat? So what do you think a bus filled with 60 people you really think a bunch of and these people are sitting down in front of the bus okay, these people are sitting in front of the bus and they go. There's people in the street  14 00:04:21,240 --> 00:04:22,300 you idiot,  15 00:04:22,440 --> 00:04:29,900 so they're calling the bus driver and idiot. It's like you're the idiot. You think the bus is going to stop and you're sitting in the street and you think you can stop  16 00:04:30,080 --> 00:04:30,980 the bus,  17 00:04:31,400 --> 00:05:12,140 especially you know you've seen. I guess the difference is if it would have been like a like a BLM rally or something like that, they least would have been smart and thrown a brick through the windshield of the bus and yank the bus driver out and beat the shit out of them. That's how you stop the bus. You don't just stand the gun. Oh my God oh, you're gonna hurt the activists bro. You're standing in the street and plus how was stopping a car? How was a car just sitting in the road idling right? Like a big bus engine? God, I don't even know what the fuck type of engine is in a commercial bus. Right? A passenger bus considering they got a hall all these fucking burger eating whales around. You think that things got some serious horsepower. Okay  18 00:05:12,840 --> 00:05:14,500 and they gotta haul.  19 00:05:15,120 --> 00:06:13,880 They gotta haul all the poor fat white people around and why is it poor people are. I guess it's cause fast food is cheap, but vegetables are cheaper than fast food, you know. I mean, that's why I don't like fat people like if. You can't even control what you put in your mouth. How the fuck am I gonna trust you then anyways so the bus has a lot of power. Obviously right? So you get these skinny soy white people. They want to go stand in front of the bus and stop the bus from going anywhere and you think that is gonna tell the oil companies to stop drilling offshore or that's gonna tell the auto manufacturers to stop making cars, or that's gonna like shut down the beef industries because the cow farts allegedly are causing way more damage to the ozone layer. Then Leonardo to caprio's private jet, or you know all the celebrities going back and forth from epstein's Island which we will never see the logs of. We will see everything about Trump, Andrew Tate, Alex Jones, all these people who are just saying mean things we'll never see anything about the Epstein Islands list  20 00:06:13,880 --> 00:06:56,540 because they're gonna be distracted telling us about January 6 Brieters and the hilarious thing about that okay, the people that are moan. I'm not agreeing with January 6. That was a stupid thing. As soon as I saw I was like, oh my god, what are these people doing? But also that was pent up anger from watch and left wing protests for over a year. So that's one thing people like to throw to the side that a week before the entire fucking city of D. C. Was on fire. People protesting the cops and then as soon as we pulled the cops out everywhere just went to shit. Look at San Francisco and all these like big liberal cities, but anyways the people that were the most worked up about January 6. Ironically, a lot of these people are really citing with Palestine  21 00:06:56,680 --> 00:06:57,660 and  22 00:06:58,040 --> 00:07:04,540 not so much Palestine even but Hamas right? Like those are 2 separate entities and what Hamas did was go and  23 00:07:05,560 --> 00:07:06,160 over  24 00:07:06,160 --> 00:08:05,940 try to overthrow another region and they went in and they slaughtered civilians. So if you're more upset about a couple rednecks putting their feet on Nancy pelosi's office, you know, on her desk. If you're more upset about the rednecks putting their feet on Nancy pelosi's desk, then you are about terrorists taking gliders into a music festival and slaughtering a bunch of kids. There's something wrong with you. Um, I really didn't see the, but it makes sense. It makes sense while these like really left wing people are sighting with the Hamas shit because at the heart of it they're all just kind of terrorists that wanna blame everything on everybody else. Like do the Israelis treat them kind of shitty? Yes, they obviously do, and I don't know the depths of it. But the Hamas people are obviously bad. The same way all these fucking antifa people and stuff are bad, you know the antifa people who leave their mother's basements to go and riot and then make racial tensions. Even way worse should they don't understand about  25 00:08:07,000 --> 00:08:16,900 going around and uh inciting? And I don't understand. I don't understand the left wing immunity with violence in this country. I don't understand how  26 00:08:17,760 --> 00:08:18,080 it  27 00:08:18,080 --> 00:09:10,080 it just doesn't make any sense. Like imagine like even right now when you see like these pro Palestine rallies where they're going around and there they're burning Israeli flags. Imagine if there was one person wearing a Trump hat in that crowd? Is there burning? Is really flexy like ah, the fucking the Nazis are back at it, you know, cause everybody likes to call everybody a Nazi that they don't agree with, but in this case you're persecuting the the the J O o's the thing I'm even too scared to say, which I'm gonna be honest with you. I don't think there's a more sensitive group of people on Earth than the J O o's because yes, they've been persecuted. Yes, they've gone through terrible things. Obviously we all know about that, but they're also at the same time the most privileged group on the planet, and if you even mention them right, if you even say the name like what happened Kong? A you can pretty much say things about every group of people  28 00:09:10,080 --> 00:09:10,880 but  29 00:09:11,720 --> 00:09:14,700 which you should be able to like we should be able to talk about things,  30 00:09:17,200 --> 00:09:17,560 but yeah,  31 00:09:17,560 --> 00:09:26,740 you say something about the J O o's and some weird shit starts happening, but it's like I've I've made. Videos trashing both sides both sides equally  32 00:09:27,240 --> 00:09:28,860 if you really go. Oh, you're just,  33 00:09:30,400 --> 00:10:29,800 you know, if you trash them both equally, at least the people that support Palestine realize you're trashing both sides like the super pro Israel people think you're just like, oh, you're anti semic, anti semitic. I don't even know what that means. Dude, I don't really, I don't even know what the fuck Jews believe to be honest with you, I just know that typically Jews have a lot of money. Stick together. They're good, you know. Nice people for all I know and uh yeah, I really don't know what they believe in and the whole point of anybody being offended case stripped back. Any one particular group like the idea of being offended in general like nobody gives a fuck. Nobody gives a fuck if your feelings are hurt. We have this thing like I heard. Uh, it cracks me up with this term trigger warning, right? Somebody says, oh, trigger warning, so I'm about to say something that might trigger you. I don't give a fuck and nobody should give a fuck if somebody is offended by words. Dude, they weren't supposed to make it this foreign the evolutionary chain. Do you think that people that got blown up in the hospital over in Gaza when the Palestinian rocket fell short and blew up all their own kids  34 00:10:29,800 --> 00:11:29,380 and then they wanted to get on TV neck like they're the victims of? Israel again, when that happened, you think there god trigger warning. This missile is about to fall from the sky and fucking kill all of us. This idea that we're so comfortable in the West where we care about people's fucking like feelings, right? Where we care about people's feelings? Well, if you say like what is hate, what is hate speech, you know what I mean. It's just fucking words. It's like when it's talking about rappers taking themselves so serious for just rhyming words and all they're talking about is bitches and bottles in the club and you know chicks with fat ass is throwing it back and pouring champagne on it and doing blow off titties and whatever the fuck rappers do these days I don't know. I think they're actually just sipping cough syrup the whole time cause I hear that line on I hear rappers in their songs talking about. I never catch a cold cause I'm sipping all this cough syrup which became illegal as soon as just in Bieber tritics. Now the white kid started sipping on SIRP, but anyways  35 00:11:31,120 --> 00:12:23,660 I forgot what I was. Oh yeah, being offended it doesn't matter, did nobody cares? If you're offended I particularly don't care, and I almost kind of get off on it. Like if I know that somebody like I'm not a bully by any means, but if I know that somebody's gonna crumble under words, that's hilarious to me like I think of. You almost as less of a person. I don't think of you as an equal. I just think of you as less of a person and typically I won't go after you because that's what bullies do. Bullies go after weak people. I only go after what I see are worthy opponents. That's why I like cracking on the left so much because they're in charge of everything. But if somebody is gonna crumble under fucking words, right? If somebody can't handle fucking words, I can't take anything like fat people and offended people. I can't take you serious. There's nothing about you like I don't want to be friends with you  36 00:12:26,040 --> 00:12:28,640 like imagine letting words affect you that much,  37 00:12:28,640 --> 00:12:29,440 dude  38 00:12:30,280 --> 00:12:47,900 just nobody cares and even even the people that pretend they care. They don't really care like you're not oppressed. If you live in the United States, I'm sorry you're not oppressed. A lot of most people that claim to be oppressed. They are just putting themselves there because they're making terrible decisions or they're begging for attention which they' don't need.  39 00:12:49,280 --> 00:12:50,000 It's  40 00:12:50,000 --> 00:12:57,740 like I mean look at what's going on in the world and I'm not saying that you know, some terrible thing makes a bad thing any less bad  41 00:12:58,440 --> 00:13:00,840 but I guess I guess it does.  42 00:13:00,840 --> 00:13:55,760 It shouldn't always be, comparatively speaking, but even just stand alone events like who the fuck is oppressed in America like people come here from decrepit places right? Like war torn countries. They come here and they try a little bit and they make it happen. You know what I mean, then you get other groups of people. I just wanna blame everything on everybody else and it's like dude, where does it end? I mean this country's been around for fucking. If if somebody could come here from fucking Bangladesh right? Somebody come here with from Bangladesh with nothing and then they go get a job at like a factory. They save their money, they get an apartment. They they do these they do these little things to get themselves into position, maybe even get a grant to go to school, do things that they wanna do or put something on the Internet. That's you know, do some drop shipping or whatever it may be like the opportunities are fucking endless. So when you hear people just talking about being oppressed constantly and it's like dude  43 00:13:55,760 --> 00:13:56,620 shut up,  44 00:13:57,000 --> 00:14:04,860 nobody cares like at the end of it nobody cares nobody people might pretend that they care, but at the very core of it nobody gives a fuck  45 00:14:05,360 --> 00:14:05,880 no,  46 00:14:05,880 --> 00:14:38,840 you're not oppressed, nobody believes that you're actually oppressed. People that do believe that you are oppressed. They think that they're better, you know. I mean when you get these super super super like liberal white people who think that like they need to help black people tie their shoes. That is fucking racism to me. I think it's racist to for white people. To tell other races that no, you're not capable of things because you' look that way, that's the racism, and then they they wanna accuse the the fucking moderates. They're just like, yeah, I mean, we're all equal, maybe I had a head start, but in whatever case it may be. But  47 00:14:38,840 --> 00:14:39,600 uh  48 00:14:39,600 --> 00:14:40,540 did I really?  49 00:14:41,200 --> 00:14:42,080 And that's when people say  50 00:14:42,080 --> 00:15:26,660 so the argument is valid right? The argument is valid like oh, another white guy just run in his mouth about shitty doesn't understand okay, I don't understand what it's like to be a different race. Sure, I'll give you that, but also if you're the different race you don't understand what it's like to be a straight white man. You have no idea. So how are you going to call out my privileges? How are you going to tell me what my life is like in comparison? That's no different than me telling you what your life is like me dismissing your gripes is no different than you pretending that I have all these invisible fucking benefits that just fall from the sky news flash were all out here competing against each other, and unless you are if you're actually in a smaller group, that's why I think that' the Jews are privileged because they're in a smaller minority group and they are ahead. It's kind of how  51 00:15:27,120 --> 00:15:29,720 a lot of the times it's a cultural thing did like  52 00:15:29,720 --> 00:15:37,900 that's why you know Asians have this like crazy. Work ethic because that's just in grain in their culture.  53 00:15:37,920 --> 00:15:38,720 Um,  54 00:15:38,800 --> 00:16:12,580 and you know what you know it's crazy about Asians and math. It's not even that they're like super intellectually inferior to everybody. It's how their languages set up. The way we say this is beyond my head about explaining, but the way that we say, for instance 1314 they just say like one 3 like the way their their their languages set up. Math makes a lot more sense, but they don't communicate as directly with with uh words. It's a real weird thing if you're interested in it' go look it up. I can't tell you too much about it. I just know that  55 00:16:12,640 --> 00:16:15,300 it is a thing  56 00:16:15,560 --> 00:16:34,220 that the reason Asians are so good at math is because their language with the math makes sense where it's almost like if you speak an equation like a sometimes something the answer almost gives itself. It's like you just carry a word over and gives you the answer. So from a young age there just um yeah it just makes more sense,  57 00:16:34,640 --> 00:16:39,160 but yeah dude hell, yeah where were we at  58 00:16:39,560 --> 00:16:48,420 16 minutes 16 and 1/2 minutes? Huh? Well, I think we're gonna start winding it down bro. One thing I want to say though  59 00:16:49,280 --> 00:16:49,920 is  60 00:16:49,920 --> 00:16:52,700 I don't understand why in sports  61 00:16:53,120 --> 00:16:53,360 uh  62 00:16:53,360 --> 00:17:53,140 you have to use your last name. What if you just wanna be first name? Where did that tradition come from? Where all around the? Globe. Every different sports team, every different sport, every different culture. We decided we're gonna address athletes by their last game. What if somebody just wants to be fucking to Steve? You know what I'm saying? What if somebody just wants to have? Like if I just wanted to have Rod on my jersey and tell me, no, you gotta be Smith. I'm like, well, there's 1,000,000 other Smiths. I don't wanna be Smith. I wanna be just my first name. Yeah, who does this? Wow, that was the worst topic. It's Friday, you guys, it's Friday and I'm gonna be honest with you. So I'm in my studio right now and my cat piston here again so I got to clean the whole fucking carpets. So I'm doing this podcast really early in the morning which I don't usually do usually I do it at the end of the day when my brains all full of the shit that gets me worked up right now. To be honest with you, I'm in way too good of a mood to be even doing this fucking podcast, but it's Friday. We're heading into the weekend. I appreciate all being here.  63 00:17:53,680 --> 00:18:04,160 Hopefully at a good week. Please tell somebody. Thank you for being here. Share it on your social medias. That's how things grow. You have all the power to do that one  64 00:18:04,200 --> 00:18:04,760 more  65 00:18:04,760 --> 00:18:38,820 at a time. It's like that Johnny Cash song where he talks about building a car and he. Steals one part of a part at a time that eventually just makes this like fucked up car. I think this song is called One One Piece at a Time. Go look at how he talks about stealing one piece of a car at a time out of the factory that he works in, then he goes and builds this fucking Frankenstein thing which I know that didn't actually happen, but that's what can happen with this podcast one little piece at a time we can go tell somebody grow it spread it spread this dangerous misinformation. Let the offended people know that we don't give a fuck about them.  66 00:18:39,480 --> 00:18:39,720 Ah,  67 00:18:39,720 --> 00:19:11,980 let me be the person to fall on the sword. You just sit back in your thriving career without having any enemies and just put my voice out there to say all this bullshit for you. Um, that way you won't look like the bad guy, but the message is still getting out there. I do this for you but really thank you for tuning in this was dangerous misinformation. Happy weekend, happy Friday, uh, don't drive drunk, don't fuck any fat people and don't do bad things. Appreciate all peace out.

No entender do presidente do PSD, “a suspeição criada diminuiu de forma irreparável a confiança subjacente ao secretismo que a democracia excecionalmente permite para ação dos serviços de informações”.

As três audições desta semana na comissão de inquérito a marcar mais uma edição do São Bento à Sexta, com o líder parlamentar do PSD a registar o que considera serem as contradições entre o primeiro-ministro e o ministro das Infraestruturas e a pedir explicações fora ou dentro do Parlamento. Pelo PS, Eurico Brilhante Dias regista como "irresponsável" o pedido de demissão da secretária-geral do SIRP feito por Luís Montenegro.

Ex-presidente do Conselho de Fiscalização do SIRP defende que Eugénia Correia Cabasso não podia ter accionado o serviços de informações e mostra-se perplexo pelo actual Conselho de Fiscalização ter concluído pela legalidade da acção do SIS em ter ouvido o ex-adjunto Frederico Pinheiro. Jorge Bacelar Gouveia diz que se nada mudar pelo lado do Governo, “tem de haver uma intervenção do Chefe de Estado”.See omnystudio.com/listener for privacy information.

O Conselho de Fiscalização do SIRP (CFSIRP) vai hoje ser ouvido no Parlamento, depois de se ter apressado a ilibar a actuação do SIS na recuperação do computador do Ministério das Infraestruturas, contrariando a maioria dos juristas que se pronunciaram sobre este caso. Há ainda muitas questões sem resposta: Quem falou com a secretária-geral do SIRP? E quem deu a ordem para o SIS avançar? Na comunicação ao país, o Presidente lembrou que o SIS está, por definição, ao serviço do Estado e não do governo. Neste episódio, conversamos com António Rodrigues, ex-membro do CFSIRP.See omnystudio.com/listener for privacy information.

As duas audições serão sobre “o contexto e enquadramento legal da intervenção do SIS na recuperação de equipamento informático e documentos classificados na posse de um ex-adjunto do ministro das Infraestruturas”, João Galamba.

Numa nota hoje divulgada, o Conselho de Fiscalização do SIRP esclarece que, na sequência das notícias vindas a público no passado dia 18 relativas ao envolvimento do Sistema de Informações e Segurança (SIS) na recuperação de um computador portátil do Estado, “de imediato e por sua própria iniciativa, diligenciou no sentido da obtenção da informação necessária ao cumprimento da sua missão de fiscalização”.

Lied-duo Priit Volmer ja Jaanika Rand-Sirp on võtnud ette romantismiaja laululooja, varalahkunud Franz Schuberti viimase laulutsükli "Luigelaul".

Fernando Negrão, vereador do PSD em Setúbal, diz que caso deve ser investigado pelo secretário-geral do SIRP. Rodrigo Adão da Fonseca fala sobre a falta de valorização da proteção de dados em Portugal See omnystudio.com/listener for privacy information.

Social Intervention!!!! Ah ah This was a very insightful and informative information… Journalism done well! More citizens needs to be aware of this.. Credits to SirP tor this valuable info pls watch and listen https://youtu.be/3fLQG-8ODus

SirP has exposed that firing the commissioner cannot help the crime rate in Jamaica but change the in the LAWS and legislation Which will help getting the criminals off the road.. there's not strong law In Jamaica to held keep criminals off the streets..https://youtu.be/ni5lZSJ-dqI

SirP share is thoughts on arm the citizens with license firearm…,https://youtu.be/8J_G39tqVBA

Credits to Politricks watch you can view the full video with link below https://youtu.be/9tmJPAkQ_WM

Riigikogu on jõudmas kokkuleppele, millised on riiklikult tähtsad kultuuriobjektid ja millele raha anda. Saates arutlevad kultuurvaldkonna sõbrad, Tartu ülikooli raamatukogu direktor Krista Aru ja kultuurilehe Sirp peatoimetaja Kaarel Tarand, Eesti kultuurivaldkonna tuleviku üle.

Today we will be talking about SIRP, and coming to theater movies, and also Rest In Peace Ms. Shiba --- Send in a voice message: https://anchor.fm/nessa-jpop/message Support this podcast: https://anchor.fm/nessa-jpop/support

OSE Immunotherapeutics est une société de biotechnologie en phase clinique. Elle développe des immunothérapies innovantes, en direct ou via des partenariats, pour l’activation et la régulation immunitaire en immuno-oncologie et dans les maladies auto-immunes. Retour sur les dernières actualités de la biotech. La société a annoncé récemment “l’obtention d’un accord de délivrance par l’Office Européen des Brevets (OEB) pour FR104, un antagoniste first-in-class sélectif du CD28, au stade de développement clinique de phase 2. Ce brevet européen protégera les modalités d’administration innovantes du FR104 jusqu’en 2036 dans la prévention et le traitement des maladies auto-immunes médiées par les lymphocytes T, les maladies inflammatoires, la transplantation et la maladie du greffon contre l’hôte (GVHD, graft-versus-host disease)“. Mon invité est Alexis Peyroles Directeur Général OSE Immunotherapeutics.    Le secteur des biotechnologies vous intéresse, retrouvez toutes les vidéos liées cet univers via ce lien : Vidéos Biotech (https://www.labourseetlavie.com/tag/biotech)   A PROPOS D’OSE IMMUNOTHERAPEUTICS OSE Immunotherapeutics est une société de biotechnologie en phase clinique. Elle développe des immunothérapies innovantes, en direct ou via des partenariats, pour l’activation et la régulation immunitaire en immuno-oncologie et dans les maladies auto-immunes. La société dispose de plusieurs plateformes technologiques et scientifiques : néo-épitopes, anticorps monoclonaux agonistes ou antagonistes, idéalement positionnées pour combattre le cancer et les maladies auto-immunes. Son portefeuille clinique et préclinique de premier plan a un profil de risque diversifié : –        Tedopi® (combinaison innovante de néo-épitopes) : produit le plus avancé de la Société ; résultats positifs de l’étape 1 de la Phase 3 (Atalante 1) dans le cancer du poumon avancé (Non-Small Cell Lung Cancer) chez les patients en échec après traitement par checkpoints inhibiteurs.  En Phase 2 dans le cancer du pancréas (TEDOPaM, promotion GERCOR), en monothérapie et en combinaison avec le checkpoint inhibiteur Opdivo®. –        BI 765063 (OSE-172, anticorps monoclonal anti-SIRP? sur l’axe SIRP?/CD-47): développé en partenariat avec Boehringer Ingelheim ; inhibiteur de point de contrôle myéloïde en Phase 1 dans les tumeurs solides avancées. –        OSE-127 (anticorps monoclonal humanisé ciblant le récepteur IL-7) : développé en partenariat avec Servier ; résultats de Phase 1 positifs ; démarrage prévu au 4ème trimestre 2020 de deux études cliniques de Phase 2 prévues dans la rectocolite hémorragique (promotion OSE Immunotherapeutics) et dans le syndrome de Sjögren (promotion Servier). –        FR104 (anticorps monoclonal anti-CD28) : résultats de Phase 1 positifs ; prêt à entrer en Phase 2 dans les maladies auto-immunes ou la transplantation. –        BiCKI® : plateforme de protéines de fusion bispécifiques construite autour d’une ossature centrale anti-PD-1 (OSE-279) fusionnée à de nouvelles cibles d’immunothérapies ; 2ème génération d’inhibiteurs PD-(L)1 pour augmenter l’efficacité antitumorale. D’autres programmes innovants en recherche. –        CoVepiT : vaccin prophylactique contre le COVID-19 développé à partir de néo-épitopes optimisés du SARS-CoV-2. Résultats positifs en préclinique et ex vivo chez l’homme publiés en août 2020 et phase clinique prévue fin 2020/début 2021. L’article Alexis Peyroles Directeur Général OSE Immunotherapeutics : “Nous avons les moyens d’accélérer si on le souhaite” (https://www.labourseetlavie.com/strategie-et-resultats/alexis-peyroles-directeur-general-ose-immunotherapeutics-nous-avons-les-moyens-daccelerer-si-on-le-souhaite) est apparu en premier sur La Bourse et la Vie TV L'information éco à valeur ajoutée (https://www.labourseetlavie.com) .

Mis võiks olla ühist koolikiusamisel ja ajalehtede arvamusrubriigil? Kas arvamustoimetajaid tõesti avaldavad lugusid, mida nad muidu ei ilmutaks, vaid hirmust maailmavaatelise kallutatuse süüdistuste ees, selleks, et kiusajad neid rahule jätaksid? Kas Danske panga rahapesu uurimise materjalide leke Itaalia ajakirjandusse seab ohtu süütuse presumptsiooni ja ausa kohtupidamise või lööb peagi uue naela kohtupidamise avaliku kajastamise kirstu? Mida paljastas möödunud nädalal 80 aasta juubelit tähistanud kultuurilehe Sirp toimetuse tööjuhend aastast 2003? Kõike seda, vähemalt osakest sellest ja palju muudki püüavad esmaspäevases saates „Olukorrast ajakirjanduses“ lahata Rein Lang ja Väino Koorberg.

A Their Story interview with Sean Martin and Marco Ciappelli Guest: Faiz Ahmad Shuja, Co-Founder The organization telling us their story today is SIRP. Taking aim at response is the future of protection We’ve arrived at a time in business where we can no longer rely on manually fighting the status quo as a means to protect the organization from compromise. We’ve reached a point where organizations must prepare for the inevitable and take aim at defining and implementing the best possible breach response capabilities—driven by intelligence and orchestrated with automation. Listen to today’s episode as Faiz Shuja shares the SIRP story with us, giving us a view into what the future holds for the security orchestration and automated response market. Have a listen to this story! Learn more about SIRP on ITSPmagazine here: https://www.itspmagazine.com/company-directory/sirp For more stories from RSA Conference 2020, be sure to visit https://www.itspmagazine.com/rsa-conference-usa-2020-rsac-san-francisco-coverage

Esimeses Trükipressis vaatame üle märtsi esimeses otsas ilmunu. Jutuks tuleb filosoofia õpikusse surumine, eneseabitööstus ja vana hea eesti keele ja kultuuri kaitse. Mikrofonide taga on Daniel Tamm ja Robert Varik. Nimekiri vaagitud tekstidest: Eik Hermann: "Naeruväärne koloniseerimine" Sirp 01.03 Henrik Sova: "Filosoofiatiigis pole madalat vett" Sirp 21.12 Leo Luks: "Igav on, härrased vannutatud mehed!" Akadeemia 3/2019 Bruno Mölder, Roomet Jakapi, Marek Volt: "Sissejuhatus filosoofiasse" TÜ Kirjastus 2018 Tõnis Jürgens: "Eneseabitööstus ja -pohmell" Müürileht 3/2019 Yuval Noah Harari: "Sapiens: A Brief History of Humankind" Harvill Secker 2014 Yuval Noah Harari: "Homo Deus: A Brief History of Tomorrow" Harper 2017 Daniele Monticelli: "Paremkonservatiivid muudavad eesti keele malakaks" Postimees 11.03

Seekord räägime ise- ja väikekirjastamisest ning e-raamatutest. Stuudios on kultuurilehe Sirp kirjandustoimetaja Pille-Riin Larm, kirjastuse Tänapäev peatoimetaja Tauno Vahter ning saatejuhid Maarja Vaino ja Peeter Helme. "Vasar" on eetris reedel kell 14.05.

Seekord räägime ise- ja väikekirjastamisest ning e-raamatutest. Stuudios on kultuurilehe Sirp kirjandustoimetaja Pille-Riin Larm, kirjastuse Tänapäev peatoimetaja Tauno Vahter ning saatejuhid Maarja Vaino ja Peeter Helme. "Vasar" on eetris reedel kell 14.05.

Hooaja esimene "Vasar" alustab. Käsitleme saates värske kultuuriajakirjanduse uuringu tugevaid ja nõrku külgi ning arutleme kultuuriajakirjanduse üle üldisemalt. Stuudios kultuurilehe Sirp peatoimetaja Ott Karulin, kirjandusteadlane Maarja Vaino ning Peeter Helme. "Vasar" on eetris sel reedel kell 14.05.

Hooaja esimene "Vasar" alustab. Käsitleme saates värske kultuuriajakirjanduse uuringu tugevaid ja nõrku külgi ning arutleme kultuuriajakirjanduse üle üldisemalt. Stuudios kultuurilehe Sirp peatoimetaja Ott Karulin, kirjandusteadlane Maarja Vaino ning Peeter Helme. "Vasar" on eetris sel reedel kell 14.05.

Sel nädalal räägime naistest, mälestustest ja elulugudest ning küsime, kas naised mäletavad meestest erinevalt ja erinevaid asju. Stuudios on Tartu Ülikooli kirjandusteooria õppejõud Leena Kurvet-Käosaar (foto: Tartu Ülikool), kultuurilehe Sirp kirjandustoimetaja Pille-Riin Larm ja saatejuht Peeter Helme. Vasar on eetris reedel kell 14.05.

Sel nädalal räägime naistest, mälestustest ja elulugudest ning küsime, kas naised mäletavad meestest erinevalt ja erinevaid asju. Stuudios on Tartu Ülikooli kirjandusteooria õppejõud Leena Kurvet-Käosaar (foto: Tartu Ülikool), kultuurilehe Sirp kirjandustoimetaja Pille-Riin Larm ja saatejuht Peeter Helme. Vasar on eetris reedel kell 14.05.

Stuudios on Pille-Riin Larm (pildil) kultuurilehest Sirp ja Kajar Pruul kultuuriajakirjast Vikerkaar. Saadet juhivad Mihkel Kunnus ja Peeter Helme. Vasar on eetris reedel, 29. aprillil kell 14.05.

Stuudios on Pille-Riin Larm (pildil) kultuurilehest Sirp ja Kajar Pruul kultuuriajakirjast Vikerkaar. Saadet juhivad Mihkel Kunnus ja Peeter Helme. Vasar on eetris reedel, 29. aprillil kell 14.05.

Just sellise teekonna läbis 27-aastane Aro Velmet eelmise reede kriitilistel tundidel. Aro planeerimata maandumine Tallinnas annab meile võimaluse juttu ajada tema doktoritööst New Yorgi ülikoolis, ajalehe Sirp eelmisel aastal Arole preemia toonud intervjuust maailmakuulsa majandusteadlase Thomas Pikettyga, senistest valikutest ja võluvast muretusest, millega ta ütleb, et et teagi täpselt, mis on elus järgmine suur eesmärk. Saatejuht on Kaja Kärner.

Just sellise teekonna läbis 27-aastane Aro Velmet eelmise reede kriitilistel tundidel. Aro planeerimata maandumine Tallinnas annab meile võimaluse juttu ajada tema doktoritööst New Yorgi ülikoolis, ajalehe Sirp eelmisel aastal Arole preemia toonud intervjuust maailmakuulsa majandusteadlase Thomas Pikettyga, senistest valikutest ja võluvast muretusest, millega ta ütleb, et et teagi täpselt, mis on elus järgmine suur eesmärk. Saatejuht on Kaja Kärner.

Pisut enam kui nädal tagasi avalikkuse ette jõudnud skandaal ajalehe Sirp uue peatoimetaja määramise protsessist päädis eile õhtul kultuuriminister Rein Langi teatega oma kohalt tagasi astuda. Stuudios arutlevad protsessi ning kultuuri käekäigu üle kunstnik Peeter Laurits ja Maalehe peatoimetaja Aivar Viidik, kes otsivad vastust ka küsimusele: kas nüüd on siis kõik korras? Saatejuht on Kärt Anvelt. (Kärt Anvelt.)

Valimisteni jäänud nädala eel on paslik kokku võtta, millise mulje on erinevad piinlikud ja veidi vähempiinlikud aktsioonid ning skandaalid jätnud ning mida siis valijatele ikkagi lubatud on. Kuna põhitähelepanu on ka meedia poolt taas suunatud eelkõige Tallinnale, on paslik küsida, kas Tallinn on ikka kogu Eesti. Saatekülaline on Erakondade Rahastamise Järelevalve Komisjoni liige ja ajalehe Sirp peatoimetaja Kaarel Tarand. Saatejuht on Kärt Anvelt. (Kärt Anvelt)

The SIRPs are a recently discovered family of glycoproteins comprising more than 30 members belonging to the immunoglobulin superfamily. The two different structural subtypes, termed SIRP α and SIRP β, are distinguished by the presence or absence of a cytoplasmic domain, respectively. SIRP α1, the first member of the family to be purified, had been characterised as a negative regulator of signal transduction, and transformation assays had suggested that it also had tumour suppressive effects. Little or nothing is known about the possible function of either the other SIRP α homologues or the members of the SIRP β subtype. The Ig-like domains possessed in the extracellular domains of all SIRPs suggest they have binding partners outside the cell. Cell adhesion experiments using the extracellular domains of SIRP family members showed that SIRP α have adhesion molecule properties. This led to the identification of CD47 as one ligand for SIRP α, performed in collaboration with others21and confirmed here. Furthermore, these experiments suggested that SIRP α molecules have at least one further unknown ligand that is not CD47. The discovery that SIRP α was a cell adhesion molecule with a regulatory role in signal transduction was expanded by in vitro kinase experiments and experiments with inhibitors of tyrosine kinases. They showed that SIRP α associated with more than one kinase activity, and that cytosolic tyrosine kinases, probably of the srcfamily, were necessary for SIRP α to regulate tyrosine phosphorylation of a receptor. In contrast to SIRP α molecules, proteins belonging to the SIRP β subtype remain uncharacterised. Therefore a large part of this work concentrates on the SIRP β subtype, its associated proteins, localisation and possible function in a cell. In vitro association experiments revealed that SIRP β is part of a multiprotein complex at the cell membrane, where SIRP β1 interacted with DAP12, an adaptor protein with a transmembrane domain. DAP12 linked SIRP β to a cytosolic tyrosine kinase identified as Syk confirmed by western blot and PCR from cDNA preparations of the cell lines used in these experiments. The interaction of Syk with the complex required the tyrosine phosphorylation of DAP12. Coligating SIRP β molecules at the membrane with a SIRP β-specific monoclonal antibody recruited Syk to DAP12 where it could be activated by treatment with sodium pervanadate. In vitro kinase assays detected several unknown phosphorylated proteins associated with SIRP β/DAP12/Syk when Syk was activated that may represent signalling molecules operating downstream of the complex. Cotransfection experiments showed that SIRP α complexed with kinase activities that enabled it to inhibit both DAP12 tyrosine phosphorylation and Syk kinase activity. This suggested that both complexes at some point operated in close contact, so experiments were carried out to localise SIRP proteins in the cell. Fractionation experiments discovered that SIRP α and possibly SIRP β could be detected in fractions that contained GPI microdomains, or caveolae. Similar investigations with the SIRP β1/DAP12 complex revealed that DAP12 was dependent upon SIRP β for its direction to the plasma membrane where it was activated by tyrosine kinases. Membrane localisation of SIRP β was similarly reliant upon DAP12 expression, however, further experiments suggested that SIRP β may be secreted from the cell in the absence of DAP12. To address the potential role of SIRP β1/DAP12 complex in signal transduction, cell lines overexpressing SIRP β and DAP12 were analysed. Cell death assays suggested that the SIRP β1/DAP12 complex was a negative regulator of induced cell death, and that tyrosine kinases might be involved in this regulation. Cells overexpressing SIRP β and DAP12 showed an enhanced rate of acid production, corresponding to an enhanced rate of glucose metabolism. These observations suggests that, SIRP β1/DAP12 overexpression may be a factor that contributing to a transformed phenotype, works in opposition to SIRP α molecules. This work views the SIRPs as components of a cluster of different proteins at the cell membrane that recruit and use other cytosolic proteins, among them tyrosine kinases and phosphatases. It shows that SIRP α molecules may collaborate with SIRP β family members to modulate the signals generated by other receptors in signal transduction. This modulation may influence aberrant cellular processes that lead to disease.