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Počítačový vedec Michal Valko sa umelej inteligencii venuje viac ako 30 rokov. Jeho cesta viedla z rodných Košíc až do najprestížnejších svetových technologických inštitúcií, kde pracoval na vývoji systémov pre giganty, ako je Intel, Meta či Google DeepMind.Michal vyrastal v metropole východného Slovenska, kde ho matematika fascinovala už od detstva. Na špeciálnom matematickom gymnáziu sa formoval v komunite,ktorú s úsmevom nazýva „matematická mafia“. Bolo to prostredie plné nadšenia, kde sa organizovali semináre a sústredenia na takej úrovni, že dostať sa na ne bolo pre mnohých iba snom. Po štúdiu v Bratislave považoval zaprirodzené pokračovať v akademickej ceste v USA , čo mu otvorilo dvere do globálneho vedeckého sveta. Postupne sa vypracoval na experta, ktorý stál pri zrode parížskeho Google DeepMind. Neskôr v spoločnosti Meta viedol výskumprelomových jazykových modelov Gemini 1 a 2, ako aj modelu Llama 3.Dnes Michal Valko nielen prednáša a publikuje, ale ako founding researcher vo vlastnom startupe Isara Labs priamoformuje kolektívnu inteligenciu a novú generáciu umelej inteligencie. Okrem podpory desiatok startupov zameraných na klimatické zmeny či medicínu sa venujevlastným projektom. Jeho cieľom je vytvoriť energeticky efektívne modulárne modely a automatizovať vedu prostredníctvom kolektívnej inteligencie. Stojí za vznikom takzvaných neo-labov, ktoré hľadajú nové spôsoby, ako o umelej inteligencii premýšľať a ako do nej investovať.Podľa Michala umelá inteligencia v blízkej budúcnosti prestane byť konkurenčnou výhodou a stane sa bežnou súčasťou nášho „skillsetu“, podobne ako je dnes internet. Keďže umelú inteligenciu vníma ako multiplikátor našich schopností, otvára sa nám priestor na hlbšiu otázku: Kde je naša skutočná ľudská pridaná hodnota? Tento rozhovor je pozvánkou na premýšľanie o svete, v ktorom strojeovládajú kód, ale človek musí držať v rukách zmysel a smerovanie. Michal Valko patrí k najvýznamnejším globálnym expertom na umelú inteligenciu a strojové učenie. Aktuálne zastáva pozíciufounding researcher v technologickom startupe Isara Labs, pričom jeho kariéra zahŕňa kľúčové vedecké posty v spoločnostiach Intel, Meta a Google DeepMind. Ako hlavný vedecký pracovník (Principal Scientist) v spoločnostiDeepMind viedol výskumný tím zodpovedný za vývoj a alignment prelomových jazykových modelov Gemini 1 a 2 a potom v spoločnosti Meta Llama 3.Svoju vedeckú cestu začal na Gymnáziu Alejová v Košiciach a Fakulte matematiky, fyziky a informatikyUniverzity Komenského v Bratislave, odkiaľ pokračoval na Carnegie Melon a University of Pittsburgh, kde v roku 2011 obhájil doktorát. Michal sa špecializuje na navrhovanie autonómnych algoritmov s minimálnym ľudskýmdohľadom, predovšetkým v oblastiach deep reinforcement learning a self-supervised learning. Okrem pôsobenia v komerčnom sektore je kmeňovým výskumníkom v inštitúte Inria a prednáša na prestížnej parížskej ENSParis-Saclay. Svojím inovatívnym prístupom ku škálovaniu a k efektivite veľkých jazykových modelov (LLM) dnes Michal Valko priamo formuje budúcnosť globálneho ekosystému umelej inteligencie. O podcastePodcast Veda na dosah vznikol preto, aby sa k slovu dostali naše odborníčky a naši odborníci. Slovenská vedaje plná osobností, ktoré denne objavujú svet, aby sa nám mohlo ľahšie žiť. V epizódach môžete počuť výskumníkov z rôznych vedeckých oblastí.Všetky podcasty Veda na dosah sú dostupné na stránke vedanadosah.sk, na Youtube CVTI SR, cezaplikácie Spotify a Apple Podcasts a naďalších streamovacích platformách.
In this episode of Data in Biotech, host Ross Katz sits down with Sadegh Salehi, Director of Research and Principal Scientist at Overjet, to explore what rigorous model evaluation actually looks like when the stakes are clinical. Overjet builds FDA-cleared vision models that detect and quantify dental disease across billions of X-ray images from thousands of practices - a data problem with a staggering number of dimensions. Thirty-two teeth per adult patient, each with different morphology. Multiple image types capturing different anatomy. Fifteen to twenty sensor manufacturers producing perceptually distinct images, each with different contrast, resolution, and noise characteristics. And disease severity distributions ranging from barely visible early-stage decay to obvious pathology. Sadegh walks through what it takes to evaluate models responsibly across all of those dimensions and discusses why aggregate metrics like F1 score can mask catastrophic failures on specific subgroups, how models find and exploit shortcuts in training data, and why the same flawed sampling that creates gaps in your training set also creates them in your test set. He also traces Overjet's architectural evolution from over twenty narrow task-specific models to a single foundation model they call Unity, explains how treatment plan procedure codes provide a noisy but real production feedback signal, and describes how Overjet became one of the first companies to secure the FDA's Predetermined Change Control Plan (a framework that allows model updates without filing a new clearance each time.) What you'll learn in this episode: >> Why aggregate evaluation metrics are insufficient for high-stakes medical AI >> How models exploit shortcuts in training data: if all images from a rare sensor in the training set happen to be healthy, the model doesn't learn to read that sensor, it learns that the sensor means healthy, bypassing the visual task entirely and producing systematic false negatives in production >> How Overjet evolved from over twenty narrow, sensor-specific and indication-specific models into a single foundation model called Unity, using noisy labels generated by the small models as the training signal for a much larger backbone, then building independent prediction heads for each clinical indication on top of it >> Why the decision to keep prediction heads architecturally independent from one another was driven as much by FDA regulatory strategy as by modeling considerations >> How Overjet uses dental treatment plan procedure codes as a production monitoring signal Meet our guest: Sadegh Salehi is Director of Research and Principal Scientist at Overjet, where he leads the team responsible for building, evaluating, and deploying FDA-cleared vision models for dental disease detection and quantification. Connect with Sadegh Salehi on LinkedIn: https://www.linkedin.com/in/sadegh-salehi/ About the host: Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/ Connect with us: Follow the podcast for more insightful discussions on the latest in biotech and data science.Subscribe and leave a review if you enjoyed this episode! Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn. https://www.linkedin.com/company/corrdyn/
On today's episode, we're joined by Sadegh Salehi, Director of Research and Principal Scientist at Overjet, a Series C AI-powered dental platform spun out of MIT.Overjet is using computer vision and AI to analyse dental X-rays, helping dentists, insurers, and patients make more accurate, transparent, and data-driven care decisions.In this episode, we explore:• The hardest machine learning challenges in dental imaging• Building AI systems clinicians and insurers can trust• Why Overjet expanded from software into hardware• What it really takes to drive AI adoption inside clinical workflows• The future of AI in dentistry over the next 5–10 yearsA fascinating conversation on applied AI, healthcare infrastructure, trust, and the future of medical imaging.
"If you don't tell your stories, then no one will ever know, …Basically I just said, I think we should tell the positive stories and we should do it through the people…Let's actually just go and meet the people at all levels from the people that are involved in the projects and organizing them. Also the people that are participating in them and benefiting from them and find out what they say. How does this change your life? Is this actually happening? Did trees actually get planted? Did this well actually get plugged?." Stacey Solie on Electric Ladies Podcast Who are the regular people on the ground saving their land and helping address climate crisis through carbon markets? Today we're going to hear from one of the producers of a new documentary about them, and be inspired to maybe think a little differently. Listen to Stacey Solie, coproducer of "From The Ground Up: Voices From The Carbon Markets" and founder and CEO of Strategic Story Craft, in this fascinating conversation with Electric Ladies Podcast host Joan Michelson. You'll hear about: ● How they found these remarkably normal people doing extraordinarily simple things and benefiting from the carbon markets to save their land. ● How these carbon market deals work as creative business models ● How to leverage creativity to reach more people about the climate crisis. ● Plus, career advice, such as: "One thing that I've done is just given myself permission to explore… sometimes saying yes to something for your community that I guess I just learned so much and I met so many people and I got exposed to really amazing artists in ways that are still playing out today. So…being open to exploring… There's different ways to do things. There's a lot of different kinds of people that are trying to make a difference, and they're all intersecting in really creative ways. And I think maybe we can take that model for solutions more broadly. Let's just get creative and work together and try to solve these problems." Stacey Solie on Electric Ladies Podcast Read Joan's Forbes articles here. You'll also like: · How To Talk 'Climate' To Keep People Safe - with Allison Agsten, USC Center for Climate Journalism & Communications · How to Talk About Climate in a Polarized Culture - with Katharine Hayhoe, Ph.D., Climate Scientist, Professor at Texas Tech University and Chief Scientist at The Nature Conservancy · Seek First to Understand - with Jennifer Hough, Advisor, TEDx Speaker, Author · How Do We Talk About Climate? - with Jill Tidman, Executive Director of The Redford Center, nonprofit producing environmental documentaries and media · What's a Tech Humanist? - with Kate O'Neill, Speaker, Tech Humanist, Author · The Politics of Climate & Energy – with Congresswoman Chrissy Houlahan, Co-Chair, Bipartisan Climate Solutions Caucus · How Climate Modelling Affects Everything – Maria Caffrey, Ph.D., Principal Scientist, UK's National Physical Laboratory Subscribe to our newsletter to receive our podcasts, blog, events and special coaching offers. Thanks for subscribing on Apple Podcasts or iHeartRadio and leaving us a review! Follow us on Twitter @joanmichelson
In this episode of the WHOOP Podcast How To Series, WHOOP Global Head of Human Performance and Principal Scientist, Dr. Kristen Holmes, sits down with renowned longevity expert, Dr. Darshan Shah, to break down how to maximize longevity. The episode focuses on what truly drives healthspan, drawing from Dr. Shah's own experience as a trauma surgeon. Dr. Shah explains why most chronic diseases are preventable and reversible and why lasting change comes from mastering the fundamentals: sleep quality, daily movement, nutrition, stress management, and consistent data tracking. The conversation explores key biomarkers, the dangers of sedentary living, the role of toxins and environment, and the importance of habit formation, purpose, and emotional health. Together, Dr. Shah and Dr. Holmes reframe longevity not as living longer, but as living better— extending vitality, resilience, and performance throughout life.(00:47) Intro to Dr. Darshan Shah, Longevity Expert(01:14) How Chronic Illness Impacted Dr. Shah Firsthand(06:15) Dr. Shah: From Trauma Surgeon to Longevity Focused Lifestyle(09:30) Building Next Health: Dr. Shah's Impact on the Longevity World(13:10) Biggest Barrier For Patients: What Trends Dr. Shah Is Seeing (19:50) The Influence of a Morning Routine on Health and Longevity(21:36) Looking At The Biggest Game Changer: Movement Throughout The Day(24:26) Eliminating The “All or Nothing” Mentality(28:23) Beyond Sedentary Behavior: Habits Declining Longevity(37:18) Best Biomarkers Promoting Longevity(48:04) Optimization Beyond Nutrition, Sleep, and Exercise (Advanced Advice)(52:28) Combatting Trauma and Understanding The Nervous System(56:18) Dr. Shah's Wellness Wheel: 12 Aspects of Health(58:52) Technological Development In Health and Longevity(59:43) Menopause and Longevity: How Women Can Mitigate Symptoms(01:08:18) Policy Changes That Will Aid Health and LongevityFollow Dr. Darshan ShahInstagram WebsiteDr. Shah's Guide to Minimizing Toxic ExposureDr. Shah's Guide to Biomarkers Support the showFollow WHOOP:Sign up for WHOOP Advanced LabsTrial WHOOP for Freewww.whoop.comInstagramTikTokYouTubeXFacebookLinkedInFollow Will Ahmed:InstagramXLinkedInFollow Kristen Holmes:InstagramLinkedInFollow Emily Capodilupo:LinkedIn
This week's flooding and severe weather in Wellington caught many people off guard, including officials. Chris Brandolino is a Principal Scientist at Earth Sciences New Zealand and spoke to Ingrid Hipkiss.
Show NotesToday we are fortunate to be talking with, John Lenneman and Josh Domeyer from Toyota's Collaborative Safety Research Center.John Lenneman is a Senior Principal Research Scientist at Toyota's Collaborative Safety Research Center and has over 25 years of human factors experience. He has worked in automotive, consumer products, and health and wellness. Before Toyota, he worked at General Motors R&D, and Newell Brands. John holds a Ph.D. in Applied Experimental Psychology from Central Michigan University and a Master's in Industrial Engineering from the University of Michigan He has authored numerous publications and book chapters and holds over 20 patents. His work spans driver behavior, vehicle automation, advanced driver assistance systems, human-centered design, and health and wellness program development Josh Domeyer is a Principal Scientist and has worked at Toyota for 14 years. Before that, he conducted research in both academic and industrial settings. Josh has Ph.D. in Industrial and Systems Engineering from the University of Wisconsin-Madison and a Master's in Experimental Psychology from Central Michigan University. He has over 50 peer reviewed publications and conference proceedings and over 20 patents. His work applies advanced computational techniques to risky driving behavior and naturalistic use of driving automation. Learn more about John + JoshConnect with John on LinkedInConnect with Josh on LinkedInSee more of their workWhere to find the hosts:Brian MoonBrian's websiteBrian's LinkedInBrian's TwitterLaura MilitelloLaura's websiteLaura's LinkedInLaura's Twitter
This week on the show, we welcome Jeremy Warren and Richard Philbrook of Dark Heart. Founded in Oakland, California in 2007, Dark Heart helped shape the modern cannabis industry through pioneering work in tissue culture, pathogen detection and large-scale genetic development-protecting and advancing the plant through years of meticulous cultivation. Jeremy Warren is the Director of Plant Genetics at Curaleaf. Jeremy has a PhD in Plant Pathology from UC Davis, has been leading Dark Heart's genetics program for over ten years, led HpLVd identification, and oversees plant genetics R&D at Curaleaf nationally and internationally. Richard Philbrook is the Principal Scientist of Genetics at Curaleaf. Richard is a Molecular biologist, studied plant genetics at UC Davis to work in cannabis, completed his Master's at Dark Heart, published researcher, and is recognized as an expert in cannabis breeding. We explore our history with the plant, favorite cultivars to cultivate and cross, and the Through the Woods launch of a new limited-edition trio of ultra-premium cannabis flower this 420.
Join us as we welcome Anahit Galtsyan, a Principal Scientist at BASF, to the Room for Discussion stage. Her work brings together the science of genomics with the realities of innovation in a global company, offering a unique perspective on how research develops in practice and how the people behind the science shape its direction.In this interview, we will explore the role of diversity in scientific progress and discuss the opportunities and obstacles facing researchers today. The conversation will touch on the broader dynamics of STEM and academia, from the ways institutions foster knowledge creation to the challenges that can stand in the way of inclusion and collaboration.
Cyclone Vaianu is expected to bring severe wind gusts, and rainfall to parts of the North Island on Sunday, with officials urging people to prepare. Chris Brandolino is a Principal Scientist at Earth Sciences New Zealand and he joins us now.
In this episode of the Friends of NPACE podcast we are joined by Haleon, the presenting sponsor of the Friends of NPACE Podcast! In this episode, Orthopedic Nurse Practitioner, Karen Myrick, & Principal Scientist in U.S. Medical & Scientific Affairs at Haleon Karin Nicholson, join us to discuss patient scenarios and when the use of Haleon products in their portfolio may be appropriate for use within the treatment plan. View additional resources below: Resources: Haleon Pain Relief Products Overview: https://www.haleonhealthpartner.com/en-us/pain-relief/brands/ Pain Portfolio Dosing Guide: https://www.haleonhealthpartner.com/content/dam/cf-consumer-healthcare/health-professionals/en_US/pdf/Pain-Portfolio-Dosing-Guide.pdf Advil new inflammation campaign page: https://www.haleonhealthpartner.com/en-us/pain-relief/conditions/itis-pain/overview/ Advil Dual Action Clinical Summary: https://www.haleonhealthpartner.com/en-us/learning-lab/educational-resources/advil-dual-action-searle-study/ Voltaren Dosing Guide: https://www.haleonhealthpartner.com/en-us/patient-care-resources/voltaren-usage-guide/ Consumer Sites: Advil Pain Relief Solutions - https://www.advil.com | Voltaren Arthritis Pain Relief Gel & Dietary Supplements - https://www.voltarengel.com
"If there are people who are willing to talk to you about it, the first thing you got to do is listen….I grew up in a very rural area and it's very conservative also. And when I go home, I don't talk about climate change. I do talk about what's going on with hunting season. 'Oh, there's no deer this year. Why do you think that is? Tell me about the rain'….It is again about that pivoting and you have to understand what's important to the people you're talking to… I might say, 'I just upgraded my mom's generator. It's great because with all the outages we're having out here, now she can get electricity and I know your husband's been sick, that could be something that could be really beneficial for you.' I do not mention climate change…I am putting out ideas that are going to save somebody's life, I'm responding to the situation of the people that I'm speaking with." Allison Agsten on Electric Ladies Podcast How do we keep people safe and sound in the face of ferocious weather, wildfires and floods, especially when they wince at the words "climate change"? Make it real for their world. How? Listen to Allison Agsten, Director of the Center for Climate Journalism and Communications at the University of Southern California in this fascinating conversation with Electric Ladies Podcast host Joan Michelson. She also curates art at the intersection of art and climate at the Wrigley Marine Science Center. You'll hear about: How to keep people safe with adaptation strategies without talking about climate change. How art and climate intersect and how it helps people stay safe. How to combat disinformation and misinformation…and so much more Plus, career advice, such as: "When I talk to women who are at some point in their careers and they're thinking of joining our sustainability communicator cohort, they always say to me, I just don't know if my skills are translatable. Yeah, they are. I can help you think about the language…It's scary because I've done it myself. I've made a number of career pivots, but to me, even scarier is not taking that chance and having the opportunity to feel really good about the work you do every day….I sleep well at night because I know that I used the skills that I have to do the thing that I think is most important." Allison Agsten on Electric Ladies Podcast Subscribe to our newsletter here -- and Read Joan's Forbes articles here. You'll also like: How to Talk About Climate in a Polarized Culture - with Katharine Hayhoe, Ph.D., Climate Scientist, Professor at Texas Tech University and Chief Scientist at The Nature Conservancy Seek First to Understand - with Jennifer Hough, Advisor, TEDx Speaker, Author How Do We Talk About Climate? - with Jill Tidman, Executive Director of The Redford Center, nonprofit producing environmental documentaries and media What's a Tech Humanist? - with Kate O'Neill, Speaker, Tech Humanist, Author The Politics of Climate & Energy – with Congresswoman Chrissy Houlahan, Co-Chair, Bipartisan Climate Solutions Caucus How Climate Modelling Affects Everything – Maria Caffrey, Ph.D., Principal Scientist, UK's National Physical Laboratory Subscribe to our newsletter to receive our podcasts, blog, events and special coaching offers. Thanks for subscribing on Apple Podcasts or iHeartRadio and leaving us a review! Follow us on Twitter @joanmichelson
Dr. Janet Anderson is a board-certified toxicologist and human health risk assessor with over 15 years of experience. Currently a Principal Scientist at Exponent, she specializes in chemical risk management, focusing on emerging contaminants like PFAS and microplastics. Noted for her expertise, she also engages in public speaking and mentoring within the field.
Every influencer is drooling over Claude Code skills files. Every product team is chasing the next model release. But for two years, the data has been screaming the same thing: capability isn't the bottleneck. Context is. This edition unpacks what that actually means — why structured business knowledge is the highest-leverage investment a product team can make, what the “context wars” look like from the inside, and why the teams winning aren't the ones with the best models. They're the ones whose AI actually understands their business.What You'll Learn in This EditionThis edition confronts the structural reason most AI products fail — they're missing the context that makes capability useful.* Why Juan Sequeda from ServiceNow says “hope is not a strategy” — and what to build instead of better prompts* The three-layer knowledge framework that gives AI a shared language across your entire organization* CNBC's “silent failure at scale” investigation reveals why 91% of AI models degrade without anyone noticing* Microsoft just adopted ontology — the same concept Juan has championed for 20 years — as the foundation of its agentic AI architecture* Citadel Securities data shows software engineer job postings rising 11% YoY despite the displacement narrativeEpisode 3: Context Is the New Moat — Why Your AI Needs Business Knowledge, Not Better PromptsEvery influencer is drooling over skills files and prompt templates. Juan Sequeda, Principal Scientist at data.world (acquired by ServiceNow), has spent 20 years proving that none of it works without structured business knowledge underneath. In this episode, Juan breaks down the three-layer framework — business metadata, technical metadata, and the mapping layer that creates real semantics — and explains why the teams investing in ontology today will compound value across every AI use case they build next. His blunt assessment of skills files as a production strategy: “Hope is an interesting strategy. It's not one that I add to my strategy.”“If you just edit in skills, I don't think that's gonna be the solution to your problem. You'll have a great POC. It'll work for the use cases you tested on. Are you willing to put your career on the line and put that in production?” — Juan SequedaListen on Spotify | Apple Podcasts | YouTubeContext isn't a nice-to-have. It's the architecture layer that determines whether your AI product delivers consistent, measurable value or drifts into silent failure. PH1 built this framework to illustrate what Juan Sequeda has been researching for two decades: intent, background, examples, and templates aren't prompt engineering tricks — they're the structural foundation that transforms an AI system from a “forever intern” into a strategic partner. Without them, you're hoping the model figures out what “order” means in your business. Hope, as Juan puts it, is not a strategy.RAG Was the Answer. Now It's a Symptom of the Real Problem.RAG dominated for two years as the default way to give LLMs context. But as context windows expanded from 8K to a million tokens, the question shifted. This video breaks down when RAG still matters — vast, dynamic datasets and cost efficiency — and when long context windows make the retrieval layer unnecessary. The strategic implication for product teams: RAG was always a workaround for a deeper problem. The real question was never “how do I retrieve the right document?” It was “does my system actually understand my business?” That's the context layer Juan Sequeda is building — and it sits beneath RAG, long context, and every other implementation detail.In spite of the displacement signals, software engineer job postings are up 11% year over year. But read the fine print: a posting titled “Software Engineer” increasingly means “engineer who can operate LLMs in production” or “build RAG pipelines.” The title stayed the same — the job changed. If your team hasn't redefined what “engineering” means in the context of AI-augmented workflows, you're hiring for yesterday's role.Product Impact ResourcesThe pattern across these resources is consistent: the teams pulling ahead are the ones investing in context, knowledge, and governance infrastructure — not chasing the next model release. Capability is table stakes. The moat is how deeply your product understands the business it serves.* Gartner predicts 80% of enterprises pursuing AI will use knowledge graphs by 2026 to enhance context and reasoning. The shift from “better prompts” to “structured knowledge” is no longer theoretical. The Role of Knowledge Graphs in Building Agentic AI Systems* Microsoft adopted ontology as the foundation of its agentic AI architecture — Fabric IQ, Foundry IQ, and Work IQ create a semantic layer that gives agents shared business understanding. Microsoft Adopts Ontology-Based IQ Layer for Agentic AI* Nathan Lasnoski argues that enterprise knowledge graphs are the foundation for moving from vibe coding to scalable agentic development — without semantic grounding, agents can't reason across systems. Building an Enterprise Knowledge Graph for the SDLC* HBR analysis reveals AI adoption stalls because of employee anxiety about relevance and identity — not technical limitations. The behavioral barriers are harder than the technical ones. Why AI Adoption Stalls, According to Industry Data* WEF data shows organizations with strong governance and >5% IT budget allocated to AI see 70-75% positive outcomes vs. 50-55% without. Governance is infrastructure, not a bottleneck. Strong AI Governance Is a Business Advantage, Not a Bottleneck* Deloitte's agentic AI strategy report calls for governance and observability as first-class product features — agentic systems should expose provenance, tool-call traces, and policy decisions by default. Agentic AI Strategy* Teresa Torres warns that AI without product discovery just means “shipping the wrong stuff faster.” The line lands directly on this edition's thesis — capability without context is an accelerant of bad decisions, not good ones. Strong potential guest. Shipping the Wrong Stuff Faster * Roger Wong unpacks Jenny Wen's (Anthropic Head of Design) “ship fast, iterate publicly, build trust through speed” approach as a new design paradigm for AI products. Jenny Wen is a compelling guest lead given her role building Claude's product experience. The Design Process Is Dead * Meta's alignment director had an OpenClaw agent start rapidly deleting her inbox — she thought it would confirm first. It didn't. She ran to a Mac mini “like I was defusing a bomb.” Stuart Winter-Tear's breakdown is a vivid, concrete case study of agentic AI failure in practice. Human in the Loop Is a Job * Academic paper in Communications Psychology (Nature) argues that friction in AI design is a feature, not a bug — challenging the default “make it seamless” paradigm. Co-authors from U of T, Wharton, and Yale. Emily Zohar is a strong potential guest with a contrarian take that plays well on the podcast. Against Frictionless AI Product Impact NewsThe news this edition reinforces a single uncomfortable truth: the biggest AI failures aren't technical — they're contextual. Systems that lack business knowledge don't crash dramatically. They drift silently, producing outputs that look right but are wrong in ways no telemetry catches.* CNBC investigated “silent failure at scale” — a beverage manufacturer's AI ordered thousands of excess cans because it couldn't contextualize new holiday labels. 91% of ML models degrade over time, and most enterprises never detect it. ‘Silent Failure at Scale': The AI Risk That Can Tip the Business World Into Disorder* Agentic AI's dominant failure mode isn't catastrophic breakdown — it's silent drift. CIO reports that only 6% of organizations have fully deployed agents, and the Cloud Security Alliance now classifies cognitive degradation as systemic risk. Agentic AI Systems Don't Fail Suddenly — They Drift Over Time* Gartner predicts 40% of agentic AI projects will be scrapped by 2027. 90% of legacy agents fail within weeks. The primary driver is governance, not technology. Why 40% of Agentic AI Projects Will Fail* Internal Microsoft data shows only 30% of Copilot enterprise licenses see weekly active usage after 6 months — despite unmatched distribution through Office. Workflow friction and unclear ROI are the barriers. Microsoft Copilot Adoption Stalls at 30% Active Usage* Virtana surveyed 350+ senior IT leaders this month: 75% of enterprises report double-digit AI job failure rates, a third exceed 25%. Meanwhile, 59% of executives think they're prepared — but 62% of practitioners report fragmented systems and visibility gaps. The disconnect is the risk. 75% of Enterprises Report Double-Digit AI Failure Rates* Citadel Securities rebuts the AI displacement narrative with data: software engineer postings up 11% YoY. But job postings requiring AI literacy grew 70% YoY — the title stayed the same, the job changed. Software Engineer Job Postings Are ‘Rapidly Rising'* Tech Mahindra and Microsoft launched an ontology-driven agentic AI platform for telecoms — the first major enterprise deployment built on Microsoft's Fabric IQ semantic layer. The context wars are real. Tech Mahindra and Microsoft Launch Ontology-Driven Agentic AI PlatformKey takeawaysThe throughline is unmistakable: the AI products failing at scale aren't missing capability — they're missing context. From CNBC's investigation into silent failures to Microsoft betting its entire agentic architecture on ontology, the market is converging on what Juan Sequeda has been saying for 20 years: structured business knowledge is the highest-leverage investment you can make.* Context is infrastructure, not a feature. Skills files and prompt templates are band-aids. The teams compounding value across AI use cases are the ones that defined “what does order mean?” before they shipped anything. If your AI can't disambiguate your business terminology, it can't deliver consistent results.* Governance accelerates adoption. The WEF data is clear: organizations with strong AI governance see 20 percentage points higher positive outcomes. Governance isn't the thing slowing you down — the absence of it is why 40% of agentic projects get scrapped.* The job didn't disappear — it transformed. Software engineer postings are up 11%, but the role now requires AI literacy. The same is true for product managers, designers, and strategists. The question isn't whether AI will replace you. It's whether you'll invest in the context that makes AI actually useful.Check Out Recent EpisodesEpisode 2: Defensibility > Capability — Five Actions to Defend Your Product Value $73.6 billion went into GenAI startups in 2025, but 85% of AI startups will be out of business within three years. This episode tackles the economics of abundance and delivers five specific actions to redirect investment toward what actually survives: workflow depth, outcome visibility, and trust engineering. If you're competing on features, you're already exposed.Episode 1: Why Your AI Metrics Are Lying to You The bullseye framework for AI products — Power, Speed, Impact, and Joy. Most teams are measuring Power and calling it success. This episode introduces a three-layer evaluation approach and shows why completion metrics hide the signals that actually matter for growth.AI Strategy Jobs* Staff Product Designer, AI Workflows — ServiceNow (Remote/Hybrid)* AI Product Manager — ServiceNow (Remote)* Product Designer, ChatGPT — OpenAI (San Francisco)* Product Designer, Platform & Tools — OpenAI (San Francisco)* AI Product Manager, Strategic Roadmap — IDC (Remote)* Principal Product Manager, AI Personalization — Cedar (New York)* Senior Product Designer, Generative AI — Coda (Remote)* Product Designer, AI Agents — Simular (Palo Alto)* Director, Product Design, AI Transformation — Element AI (Santa Clara, CA — On-site, 65% travel)* Product Designer — Fidelity (Merrimack, NH / Jersey City, NJ / Westlake, TX — Hybrid)If your AI product demos well but can't prove it drives value in production, that's a context problem — and it's the gap PH1 closes. We help teams build the measurement and knowledge infrastructure that turns AI capability into measurable business impact. From defining what success means to proving it with data. ph1.caThank you for supporting the Product Impact PodcastEvery episode goes deeper than the headlines to uncover what actually drives AI product success — and what's quietly killing it. If Juan's take on context and ontology challenged how you think about your AI product's foundation, share this episode with your team. Follow the show so you never miss one. That's how we grow this community of builders who refuse to settle for capability without impact.Browse all episodes at productimpactpod.com — filter by topic to find the episode that fits what you're working on right now. We're at 56 episodes across the two seasons. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit productimpactpod.substack.com
The Roundtable Panel: a daily open discussion of issues in the news and beyond. Today's panelists are Joseph Palamountain Jr. Chair in Government at Skidmore College Beau Breslin, Biomedical Engineer and Principal Scientist at Regeneron Ahmad Abu-Hakmeh, Senior Fellow at Bard Center for Civic Engagement Ambassador Fred Hof, and Professor of Creative Arts at Siena University Mahmood Karimi Hakak.
Welcome to the WHOOP Research Series, where we breakdown into the extensive, scientific research conducted by the WHOOP Performance Science team. On this week's episode, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with WHOOP Senior Research Scientist Dr. Greg Grosicki to unpack the latest WHOOP Research Study on Heart Rate Variability Coefficient of Variation or HRV-CV. Using data from 21,000+ WHOOP members and 2 million nights of sleep, Dr. Holmes and Dr. Grosicki reveal why day-to-day stability in your HRV may matter more than the number itself. HRV-CV proves to outperform traditional metrics in detecting the real impact of alcohol, sleep consistency, and metabolic health, making it a great measure of healthspan. By looking deeper into the study, Dr. Holmes and Dr. Grosicki explains how HRV-CV can help you program your training smarter, improve your healthspan and build autonomic resilience. This episode unpacks how measuring HRV-CV isn't just about performance, but risk stratification and understanding your physiology over-time, not just day-to-day. (01:11) Intro To The Study: Why Is HRV-CV Important? (04:09) HRV-CV and Risk Stratification(08:28) Definition of HRV-CV(11:40) What HRV-CV Indicates in Athlete Recovery(14:26) Breaking Down The WHOOP Study(17:13) HRV-CV Trends in Shift Workers(21:21) Why Is HRV-CV an Important Biomarker?(25:18) HRV-CV Trends in Individuals on GLP-1 Medications(26:29) The Weather vs. The Climate: HRV vs. HRV-CV(33:41) The Results: Breaking Down the Data(36:37) How HRV-CV Responds to Certain Behaviors(39:38) Trends Between HRV-CV Between Age, Biological Sex, and Body Mass Index(49:54) How To Improve HRV-CV(56:39) New Research Roles and Opportunities at WHOOPReferences:American Journal of Physiology PublicationHRV-CV: The Key Metric for Lifestyle Consistency and StabilitySupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
What makes Lyme disease resolve quickly in some people but turn into a life-altering chronic illness in others? In this episode, world-leading immunologist Dr. Michal “Mikki” Tal, Principal Scientist at MIT, explains what her team is discovering through the MAESTRO Study — the largest clinical research project in MIT's history and the first of its kind to include real Lyme patients in a multi-system biological analysis. Dr. Tal's work sits at the intersection of immunology, bioengineering, and women's health, uncovering how infections like Lyme and COVID can cause persistent inflammation, immune miscommunication, and hormonal imbalance. Through MAESTRO, she's mapping how recovery breaks down — and what can be done to predict, prevent, and ultimately reverse chronic illness.
🧭 REBEL Rundown 📌 Key Points 🔍 Understanding the Why: The significance of understanding underlying causes, beyond initial diagnoses, in both sports and emergency medicine is explored. ⏱️ Recovery Focus: Emphasizing the importance of recovery time and small daily choices in optimizing performance for both athletes and emergency physicians. 📊 Data-Driven Insights: The Arena Labs approach uses personalized data, leveraging wearable technology and expert coaching to tackle burnout and enhance well-being. 🤝 Personalization and Partnership: Arena Labs’ collaboration with emergency clinicians sheds light on personalized performance solutions rooted in scientific evidence. Click here for Direct Download of the Podcast. 📝 Introduction Welcome back to REBEL MIND, where MIND stands for Mastering Internal Negativity during Difficulty. Here we sharpen the person behind the practitioner by focusing on things that improve our performance, optimizing team dynamics and the human behavior that embodies the hidden curriculum of medicine. In this episode, we’re excited to continue collaboration with Arena Labs, where host Dr. Mark Ramzy interviews Allyn Abadie, Arena Labs’ Principal Scientist on how we can apply performance science in and out of the emergency department. Arena Labs is helping us measure healthcare performance through innovative programs designed to combat burnout and enhance personal wellness using data-driven strategies. 🔙Previously Covered on REBEL MIND: Performance Under Pressure – What Medicine Can Learn from Elite TeamsThe Power of Performance Coaching in MedicineRest Is Not Sleep: The Seven Dimensions of True Recovery 🤔Cognitive Question How can emergency department clinicians utilize techniques inspired by athletic performance to better manage stress, prevent burnout, and optimize recovery? 💭 Why This is Important Burnout among healthcare workers is a growing concern, especially in such high-pressure environments as emergency and intensive care units. The collaboration with Arena Labs brings forth a vital focus on using data and coaching to build resilience among medical professionals. 🏥How This Applies to the Emergency Department or ICU? Emergency medicine, akin to high-performance sports, demands intense energy and quick decision-making under pressure, often leading to stress and burnout. By applying principles from athletic recovery and personalized data tracking, clinicians can moderate their performance intensity, enhance their recovery even in short breaks, and prevent long-term burnout. This approach allows emergency physicians to maintain endurance and clarity, improving patient care and team dynamics. ⏩ Things You Can Do on Your Next Shift Measure and Reflect: Start tracking your vital health metrics like heart rate with wearable sensors. Reflect on how daily activities impact these measurements to identify stress patterns.Implement Quick Recovery Techniques: Use short, actionable exercises such as deep breathing or the de-stress breath method between patient encounters to moderate stress levels.Invest in Self-Care: Dedicate brief time slots for essential self-care activities like hydration or quick reflection journaling, aiming to enhance mental resilience throughout your shift.Utilize Coaching Tools: Engage with personalized coaching apps or resources that offer science-backed recovery strategies tailored to your personal and professional needs. 👀 Where to Learn More Intrigued by the possibilities this partnership offers? You can explore more by visiting Arena Labs’ website here. Also, check out the comprehensive coaching program available, designed specifically for healthcare providers looking to enhance their well-being and performance. 🚨 Clinical Bottom Line In an era where burnout is pervasive, our collaboration with Arena Labs offers a beacon of hope for healthcare workers. By leveraging cutting-edge data insights and practical coaching, this partnership aims to redefine healthcare wellness, fostering a sustainable, resilient workforce that’s equipped to navigate the pressures of modern medicine. Join us in this journey towards enhanced well-being and workforce empowerment, ensuring that those who care for us are also cared for. Meet the Authors Mark Ramzy, DO Co-Editor-in-Chief RWJBH / Rutgers Health, Newark NJ Allyn Abadie Principal Scientist Arena Labs REBEL MIND: Applying Performance Science In and Out of the Emergency Department In this episode, we're excited to continue collaboration with Arena Labs, where host ... Human Behavior Read More REBEL Core Cast 150.0: Emergency Medicine Consults: How to Call a Consult + Handle Pushback (With Scripts) Consults aren’t a formality—they’re a patient-care intervention. In this post, Swami breaks down ... Read More REBEL MIND – Rest Is Not Sleep: The Seven Dimensions of True Recovery Today we are exploring the imperative topic of rest and why it’s not ... Human Behavior Read More REBEL MIND: The Power of Performance Coaching in Medicine In this episode, we're excited to continue collaboration with Arena Labs, where host ... Human Behavior Read More REBEL MIND: Performance Under Pressure – What Medicine Can Learn from Elite Teams Welcome back to Rebel MIND, the podcast where we sharpen the person behind ... Human Behavior Read More REBEL MIND – The Dunning Kruger Effect: Why Looking Inward Improves Patient Care In this episode and blog post, hosts Mark Ramzy and Kim Bambach (Assistant ... Human Behavior Read More The post REBEL MIND: Applying Performance Science In and Out of the Emergency Department appeared first on REBEL EM - Emergency Medicine Blog.
For years climate scientists have warned us to expect more extreme weather - now, it seems, we're living through it. Chris Brandolino is a Principal Scientist at Earth Sciences New Zealand, formally NIWA, he spoke to Melissa Chan-Green.
"We have to begin our conversations with what really matters to the person or people we're speaking with. And if we don't know what that is, we have to get to know them and build a relationship and then start the conversation where they're at…The second common misconception I see is that we have to load up our wheelbarrow with the biggest load of scary facts we can possibly find and just dump it on people because not enough people are worried about this.…But if we haven't connected the head to the heart, my life, the places I love, the people I love, the things I love my home, the price of my groceries, the price of my insurance, the quality of the air I'm breathing, or my child's breathing, if we haven't made the head to heart connection, people still see this issue as being distant and remote from them." Katharine Hayhoe on Electric Ladies Podcast Signs of climate change are all around us, from ferocious and more frequent hurricanes, and in unexpected places, to massive wildfires and floods, as well as cracking roads and bridges. But many still don't believe it or don't want to take steps to avoid it or become more resilient. So, how can we reach them, especially in the very polarized culture we have today? Listen to Katharine Hayhoe, Ph.D. acclaimed climate scientist, Professor at Texas Tech University and Chief Scientist of The Nature Conservancy in this enlightening conversation with Electric Ladies Podcast host Joan Michelson. Katharine is also the author of several books, including "Saving Us: A Climate Scientist's Case for Hope and Healing in a Divided World." You'll hear about: ● How to talk about climate issues even without even talking about climate. ● What we can learn from the faith-based community about talking about the climate crisis. ● What is happening to the vitally important climate science data that was defunded and taken offline by the Trump administration…and so much more ● Plus, career advice, such as: "(W)hat am I uniquely good at? So there's certain things that I'm a lot better at than other people. So that's the filter that we should apply. But then my favorite's the last filter, which is what genuinely gives me joy, what charges my battery rather than depleting it. Now, of course, don't get me wrong, we all have to do things that deplete our battery every day. But if our work does not give us joy or if it gave us joy at some time in the past but is no longer doing so now, that's a sign to us to think differently about what we're doing….(And invest) in making our own lives sustainable is so important. It's something I feel like we often neglect and it falls by the wayside in our focus on everything else that needs to be sustainable. But really I think it starts with US." Katharine Hayhoe on Electric Ladies Podcast Read Joan's Forbes articles here. You'll also like: · Unique Urban Climate Actions – Joan's panel at Smart City Expo World Congress in Barcelona with three top urban leaders from around the world. · How Climate Modelling Affects Everything – Maria Caffrey, Ph.D., Principal Scientist, UK's National Physical Laboratory · Critical Minerals 101 – with Abby Wulf, Former Head of Critical Minerals at the Dept. Of Energy, & Center for Critical Minerals Strategy · The Politics of Climate & Energy – with Congresswoman Chrissy Houlahan, Co-Chair, Bipartisan Climate Solutions Caucus · Climate Is A Security Emergency – Svitlana Krakovska, top Climate Scientist from Ukraine and Mirian Villela, head of Earth Charter International and the Center for Sustainable Development with Joan Michelson at The Earth Day Women's Summit 2025. Subscribe to our newsletter to receive our podcasts, blog, events and special coaching offers. Thanks for subscribing on Apple Podcasts or iHeartRadio and leaving us a review! Follow us on Twitter @joanmichelson
A Gluten Free Podcast Episode 217 Today's highlight is from my episode with Dr. Andrew Williams, Principal Scientist at Westmead Children's Hospital in Sydney, Australia. Dr. Williams has spent decades researching coeliac disease and the complex immunological processes behind it. In the full episode we explore how coeliac disease research has evolved, what still needs to change and how early diagnosis in children could significantly improve health outcomes across Australia and globally. In this highlight Dr Williams explains a study he conducted which screened children at random in Westmead Children's Hospital for coeliac disease. Links Listen to the full episode here Join A Gluten Free Podcast Facebook group here
Welcome back to the WHOOP Podcast! To kick off the New Year, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes, sits down with 2x HYROX World Champion, Meg Martin. Meg joins the WHOOP Podcast to share what it really takes to push your physical and mental limits—without burning out. Meg shares how a childhood in gymnastics and sports aerobics built her discipline, why most people overdo intensity in their workouts, and how she and her husband balance elite performance with a focus on recovery and longevity. Meg and Dr. Holmes dives into sickness, travel, immune resilience, sleep, and why mindset work is the real secret behind achieving PRs. Meg presents the idea of “fears week”, a habit she has implemented in her coaching technique to help her clients grow on and off the HYROX course. Whether you're looking to compete in HYROX, or hoping to build a stronger focus on mental strength, this episode provides you with the habits and mindset shifts to push your performance limits. (00:47) Meg Martin's Journey to HYROX(02:11) What Is HYROX? (03:32) Building Mental Toughness For HYROX(04:43) “You Have To Love To Hurt” Why Athletes Are Drawn To HYROX(08:07) The Mindset Of A World Champion(10:29) Navigating Illness and Injury As An Athlete(14:48) How Meg Thinks About Sleep, Rest, And Recovery(18:16) Building A Supportive Team & Community(21:59) Incorporating Mindfulness in Coaching (27:54) Finding Happiness & Purpose To Overcome Fears(30:19) HYROX Training True or False Questions(36:29) Volume and Intensity Training As A HYROX Athlete(40:17) How To Build Your Pacing Instincts in HYROX(44:17) Being A Business Owner and Full-Time Athlete(46:55) A Message To New HYROX Athletes: Tips and TechniquesFollow Meg Martin:InstagramYouTubeTikTokSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
In this episode of Data in Biotech, Ross Katz chats with Jaidev Chakka, Principal Scientist at the University of Mississippi School of Pharmacy, about how 3D bioprinting and AI are reshaping pharmaceutical manufacturing. They explore the development of custom scaffolds for tissue engineering, the integration of gene delivery systems, and how data-driven approaches are enabling smarter, more scalable solutions in personalized medicine. What you'll learn in this episode: >> How 3D printing is enabling customized bone scaffolds and regenerative therapies >> The role of AI in optimizing pharmaceutical 3D printing parameters >> How organoids can act as micro-organs for testing and computation >> The promise and challenge of personalized, on-demand drug manufacturing >> Why collaboration between data scientists and biopharma researchers is critical Meet our guest LR Jaidev Chakka is a Principal Scientist at the University of Mississippi School of Pharmacy, pioneering 3D bioprinting, drug delivery, and organoid research to revolutionize patient care and pharma manufacturing. About the host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancyConnect with Jaidev Chakka on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science.Subscribe and leave a review if you enjoyed this episode!Connect with Ross Katz on LinkedIn Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn.
This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with dual-sport national team athlete and exercise physiologist Dr. Heather Logan-Sprenger. The two take a deep dive into one of the most underrated and often forgotten about habits for human performance: hydration.Dr. Logan-Sprenger shares how growing up in Northern Ontario, watching her dad water flowers and her cat grow winter fur, quietly planted the seeds for a lifelong fascination with physiology, stress, and adaptation. From competing for Team Canada in both ice hockey and road cycling to suffering from heat stroke mid–PhD on hydration, her experience and education show just how fragile — and adaptable — the human body really is.Dr. Holmes and Dr. Logan-Sprenger identify what mild dehydration does to your metabolism, brain, and overall performance, and how hydration needs shift across the menstrual cycle. This episode will teach you the simple hydration strategies, how to calculate your sweat rate at home, and when electrolytes actually matter.(01:07) Dr. Heather Logan-Sprenger Intro: Background in Sport & Physiology(01:49) Training, Nutrition, & Hydration: Unpacking Your Body's Needs(08:06) National-Level Athlete to PhD(10:51) WHOOP Podcast Rapid Fire Questions(13:08) Training At Altitude: Hydration Dos and Don'ts (14:49) The Physiology of Heat Stroke(20:33) Correlation Between Hydration and Carbs While Training(24:51) How The Menstrual Cycle Affects Hydration (31:19) Mechanisms of Dehydration: What Happens To The Body(36:52) Cognitive Disadvantages Of Dehydration(38:56) Dehydration's Effects On The Cardiovascular & Thermoregulatory System(40:35) Dehydration's Effects On The Brain (41:29) Measuring Your Sweat Rate As An Athlete(45:39) Essential Habits To Teach Kids and Athletes About Hydration(49:20) Overhydrating and Mineral Loss with Hydration(53:45) Debunking Hydration Myths(55:54) Heart Rate, Lactate, and Power Output's Relationships to Hydration(59:48) Dr. Logan-Sprenger's Ideal Hydration Study: Mitochondrial Hypoxia and Metabolism(01:05:23) OutroFollow Dr. Heather Logan-SprengerLinkedInInstagramPeakgenicsSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Welcome to the last episode of 2025 for our podcast, Under the Surface! In this episode, SVL: Santavy vs Labute - The HoliDAVE Edition, get cozy with this special holiday edition of "Under the Surface"! Chris Williams and Dave Thompson are here to share laughs, swap stories, and spread some cheer as they chat with CCG's always-jolly Principal Scientist, Martin Santavy. From the wild beginnings of programming to the everyday adventures of debugging, this episode takes you on a fun-filled ride through the world of computational chemistry. There's plenty of laughter, a sprinkle of science magic, and a whole lot of heart as we talk about the quirks of coding and the power of good communication. Whether you're a science fan or just love a great story, come join us—grab your favorite mug, settle in, and let's celebrate the season together! Listener discretion is advised. Subscribe & listen to all episodes of our podcast: https://bit.ly/3WQGPKY Follow us on LinkedIn & X
This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with fitness entrepreneur and creator of WeGlow, Stef Williams. The two discuss building an empowering global community, navigating endometriosis, redefining movement, and Stef's pregnancy journey. Stef opens up about her path from athlete to influencer, the realities of running multiple businesses, her evolving relationship with health and mindset, and how intentional lifestyle choices helped her reclaim her wellbeing. This episode highlights the power of a positive mindset, training, and understanding your body to feel stronger, more connected to your health and wellness goals. (00:00) Cold Open(00:43) Intro(02:36) Rapid Fire Questions(07:14) Stef's Background and Building WeGlow(12:26) Fighting Exercise Burnout(14:02) Common Misconceptions In The Fitness Industry(16:21) Inner Ad(16:34) Stef's Day In The Life: Entrepreneur and Fitness Influencer(20:40) Ins and Outs of Running The Business(25:20) Pregnancy, Balancing A Career, and Lifestyle Changes(28:22) How Stef Uses WHOOP For Her Health and Wellness(33:09) Inner Ad(33:42) Managing Endometriosis: Signs and Symptoms(39:02) Nutrition, Lifestyle, and Preventative Care with Endometriosis(45:09) Cycle Tracking and Navigating Pregnancy with Endometriosis(50:25) Getting A Diagnosis and Mindset Training(51:30) Stef's Goals and Motivations (56:10) Stef's Advice For Women in Training and Business(58:33) Kristen's Advice For Expecting Mothers(01:00:51) OutroStef Williams InstagramTikTokYouTubeLinkedInFacebookWeGLOWSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Computational methods can predict stability issues before the lab. But how do you actually implement these approaches in your formulation workflow? From excipient selection to long-term stability prediction, in silico tools are transforming how biotech teams develop robust formulations while reducing costly trial-and-error cycles.In Part 2, Giuseppe Licari, Principal Scientist in Computational Structural Biology at Merck KGaA, returns to share practical implementation strategies for integrating computational methods into biologics formulation development. Giuseppe reveals how molecular dynamics simulations guide excipient selection, where current methods hit their limits, and how emerging AI capabilities are expanding what's possible in formulation prediction.Whether you're at a well-resourced pharma company or a lean startup, Giuseppe offers actionable guidance for leveraging computational tools to predict protein behavior, optimize formulations, and accelerate your development timeline.Topics covered:Predicting protein aggregation and excipient interactions before manufacturing (00:45)Using molecular dynamics to understand protein behavior over time and in different environments (03:03)The interplay between computational predictions and experimental stability studies (04:49)The limitations of current in silico methods for predicting long-term stability (05:08)Emerging use of AI and machine learning to predict protein properties and improve developability (06:36)Future possibilities: Generative AI for protein design and formulation prediction (08:06)Advice for small companies: leveraging software-as-a-service and external partners to access computational tools (09:55)The impact of increasing computational power on the field's evolution (11:12)Most important takeaway: being open and curious about new computational techniques in biotech formulation (12:08)Discover how to bridge computational predictions with experimental validation, navigate the current limitations of in silico stability forecasting, and position your organization to benefit from AI-driven formulation development, regardless of your resource constraints.Connect with Giuseppe Licari to continue the conversation and explore how computational approaches can solve your formulation challenges before you ever step into the lab.Connect with Giuseppe Licari:LinkedIn: www.linkedin.com/in/giuseppe-licariNext step:Need fast CMC guidance? → Get rapid CMC decision support hereSupport the show
What if you could predict formulation failures before ever touching a pipette? Computational approaches are revolutionizing biologics development, replacing trial-and-error experimentation with predictive intelligence that catches stability issues early and accelerates your path from candidate selection to clinic.In this episode, David Brühlmann welcomes Giuseppe Licari, Principal Scientist in Computational Structural Biology at Merck KGaA. A chemist by training, Giuseppe transitioned from wet lab experimentation to the predictive power of in silico modeling. Today, he operates at the intersection of computational biology and CMC development, using digital tools to screen candidates for developability, predict formulation challenges, and de-risk development programs before committing resources to the lab.Discover how computational methods are transforming the way biotech companies approach developability assessment and formulation strategy:Why maximizing shelf life isn't always necessary in early development phases (02:56)The critical role of communication between computational and bench scientists (06:46)Core properties to assess for developability, including hydrophobicity, aggregation, charge, and immunogenicity (11:06)How accurate are in silico predictions, and where do they add the most value? (13:23)The limitations and strengths of machine learning and physics-based models in predicting protein behavior (15:19)The differences between developability, formulation development, and formulatability, and the value of early cross-functional collaboration (17:17)When to use platform formulations and when tailored approaches are needed for complex molecules (19:25)The advantages of using computational methods at any stage, especially for de-risking strategies (20:13)Listen in for practical strategies for integrating in silico predictions into your developability and CMC workflows, catching stability issues before the lab, and making smarter development decisions that save time, material, and money.Connect with Giuseppe Licari:LinkedIn: www.linkedin.com/in/giuseppe-licariNext step:Need fast CMC guidance? → Get rapid CMC decision support hereOne bad CDMO decision can cost you two years and your Series A. If you're navigating tech transfer, CDMO selection, or IND prep, let's talk before it gets expensive. Two slots open this month.Support the show
On this week's episode of the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with Rachel Otto, the first female operator of the United States Secret Service Counter Assault Team. Rachel recounts her journey from playing Division I volleyball at The Citadel, to her experience in law enforcement, becoming a federal agent in New York City, and protecting various heads of state. Rachel shares what it takes to protect the President and Vice President, from maintaining elite readiness for split-second decision making to managing sleep consistency across time zones. Dr. Holmes and Rachel breakdown the recovery, fitness, and discipline needed to thrive in a highly demanding, high-stakes job. (00:47) Meet Rachel Otto: First Female United States Secret Service Counter Assault Agent(02:57) Skillset & Training of A Counter-Assault Agent(05:06) WHOOP Podcast Rapid Fire Questions(06:00) Rachel's Experience at The Citadel(12:03) Operating In A Male-Dominated Field & Adapting To Environments (14:27) Rachel's Experience As A Law Enforcement Officer(16:22) The Mental Aspect: How To Stay Focused In A High Stress Environment(18:55) Crucial Lifestyle Choices To Show Up As A Federal Agent(24:05) Becoming A Federal Agent(27:51) Maintaining Consistency and Discipline (37:45) What It's Like Protecting The President(41:54) Circadian Rhythm, Sleep & Tracking Metrics(50:39) Rachel's Training: CrossFit, HYROX, and Exercise Snacks(59:02) Advice For Young Girls Getting Into The FieldSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
On this month's edition of the WHOOP Podcast How To Series, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with Registered Sports Dietician, Angie Asche to explore what it really means to fuel for performance as an athlete. Angie has worked with a variety of professional athletes in the MLB, NHL and more, optimizing their nutrition habits to perform at their peak.Angie outlines the importance of prioritizing the three macronutrients – carbohydrates, proteins, and fats – and how to ensure you're getting the right amount of each. This episode dives into why the timing of meals is so important, explaining the impacts nutrition has on sleep and recovery. Angie and Dr. Holmes unpack the fine line between aesthetics and performance and how under-fueling affects both male and female athletes.(00:50) WHOOP Rapid Fire Q's(01:50) Prioritizing Macronutrients As An Athlete(03:17) Under Fueling: Balancing Aesthetics and Performance(05:11) Common Symptoms of Under Fueling(06:58) Impact of Under Fuelling On Sleep and Recovery(07:42) Fasting's Impact on Performance(09:42) Importance of Nutrient Timing(12:24) Late-Night Eating: How Does It Impact Sleep and Recovery?(15:39) Food Sensitivity Tests: Are They Worth The Hype?(19:02) Knowing Inflammation: Chronic Versus Acute(23:47) Do You Need To Supplement Nutrients As An Athlete?(27:16) Supplement Absorption and Daily Nutrition(32:35) Benefits of Prebiotics & Probiotics(33:57) Why Your Body Needs Fiber & Where To Get It(35:07) How To Track Macros(38:46) Intuitive Eating: What Your Body Needs & When(40:48) Long-Term Effects of Under Fueling(41:46) The Nutrients Many Female Athletes Are Missing(44:51) Nourishment Over Numbers: Changing Mindsets On Restrictive Eating(49:30) Metabolic Health: The Nutrients To Improve Your MetabolismFollow Angie Asche:InstagramLinkedInXWebsite Support the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
"(Climate modelling)…it's being used in things like insurance companies. It's being used by companies for their ESG assessments. So, when you get your insurance premium at the end of the year, there is some kind of climate model that has said something about the risk of your house to flood. It has said something about your risk to fire. And so that might be driving up your insurance premium…And so it's being involved in your lives in many different ways. The food you consume, those grocery bills, there's prices behind it that are being driven by people using climate models saying something about the supply chain." Maria Caffrey on Electric Ladies Podcast Climate modelling is the foundation of a lot of planning and equations that so much of our economy and policy is based on. So, how does it work and how reliable is it? How can they tell? Listen to Maria Caffrey, Principal Scientist at the UK's National Physical Laboratory in this fascinating conversation with Electric Ladies Podcast host Joan Michelson. You'll hear about: ● How climate modelling actually works, and who uses it and why. ● How climate modelling measures risk and how reliable it really is – especially at a time of geological and weather patterns never seen before. ● What the economic and social impact is of how climate modelling is used today. ● Plus, career advice, such as: Read Joan's Forbes articles here. You'll also like: · Predicting Climate Impacts In Neighborhoods – with Jessica Filante Farrington, AT&T's Director of Global Sustainability · The Politics of Climate & Energy – with Congresswoman Chrissy Houlahan, Co-Chair, Bipartisan Climate Solutions Caucus · AI and Climate Solutions – with Stephanie Hare, Ph.D., Researcher, Author of "Technology Is Not Neutral" and BBC Broadcaster · Climate Policy & the Economy – with Gina McCarthy, White House National Climate Advisor, Biden Administration, and former EPA Administrator under President Obama Subscribe to our newsletter to receive our podcasts, blog, events and special coaching offers. Thanks for subscribing on Apple Podcasts or iHeartRadio and leaving us a review! Follow us on Twitter @joanmichelson
Dr. Daniel Perkins and Dr. Jennifer Karre discuss the importance of policy in supporting military-connected students and families. Listen as they examine the implementation of four policy initiatives: Advance Enrollment (AE), the Military Interstate Children's Compact Commission (MIC3), the Military Student Identifier (MSI), and the Purple Star School program. This podcast is made possible by generous funding from the West Point Spouses' Club. To learn more, visit https://westpointspousesclub.org/. Audio mixing by Concentus Media, Inc., Temple, Texas. Show Notes: Resources: Clearinghouse for Military Family Readiness https://militaryfamilies.psu.edu/ Evaluation of State Implementation of Supportive Policies to Improve Educational Experiences and Achievement for K-12 Military Children https://militaryfamilies.psu.edu/projects/view/speak-military-children/ Military Interstate Children's Compact Commission https://mic3.net Military Student Identifier https://militarychild.org/wp-content/uploads/2025/01/2025-104-MSI-Position-Statement_20250103-1.pdf Military Child Education Coalition https://www.militarychild.org Bio: Daniel F. Perkins, Ph.D., is a Professor of Family and Youth Resiliency and Policy at Penn State University and also the Director and Principal Scientist of the Clearinghouse for Military Family Readiness at Penn State, a university-wide applied research center. Dr. Perkins has been designing and evaluating strengths-based family and youth development programs in 4-H and Cooperative Extension and leading complex projects for over 25 years. His work involves teaching, research, and outreach through the Penn State Cooperative Extension Service. One of his primary areas of focus is in fostering the well-being of military service members, veterans, and their families through the Clearinghouse. In his role as Principal Scientist, he is able to facilitate the translation of science into action by providing comprehensive, science-based programs and technical assistance to professionals working with military service members, veterans and their families. Jennifer Karre, Ph.D. is a Research & Evaluation Scientist at the Clearinghouse for Military Family Readiness at Penn State. Her Ph.D. is in Developmental Psychology. For over a decade, her role at the Clearinghouse has centered around program and policy evaluation. She has worked on evaluations of programs and policies for Service Members and their families related to fathering, parenting, child and youth development, child and youth educational support, couple relationships, reintegration after deployment, financial readiness, and emergency preparedness.
As women in midlife, we're constantly juggling all the things. So, what can we do to balance all of our to-dos without feeling totally burnt out? In this episode, we're diving into the reality of energy changes during midlife and why committing to your own well-being is non-negotiable. I've invited Dr. Kristen Holmes– an expert in optimizing human performance, especially in women– to share her powerful strategies for enabling autonomic control so you can feel your best in your body. We're talking: Boosting mitochondrial energy Improving recovery and metabolic health And feeling fully resourced every. single. day We'll break down the simple yet impactful habits you can start to help you reclaim your vitality—even with a packed schedule. Because the truth is, no one is looking out for you the way YOU can. It's time to prioritize yourself, show up fully, and start feeling amazing again! Dr. Kristen Holmes Dr. Kristen Holmes is the Global Head of Human Performance, Principal Scientist at WHOOP. She engages with industry-leading researchers to better understand individual and team biometric and performance data to drive product innovation, strategy, and coaching. Kristen blends her academic and applied background in athletics, coaching, performance technology, psychology, and exercise physiology to drive research, partnership, and product development initiatives to strengthen WHOOP. IN THIS EPISODE Core behaviors that enable autonomic control The importance of HRV metrics for health, fitness, and wellness Surprising insights from WHOOP data The science behind sleep for optimal recovery Non-negotiable habits for boosting your energy Your autonomic nervous system and your stress response Incorporating movement easily into your daily routine QUOTES “If we focus on improving the health of our autonomic nervous system, we're going to then improve not only our competitive advantage just as a human but most importantly our survival advantage.” “I think it's really important for us to have the resilience to overcome the stressors and to show up for the people we love in this world.” “It's a cross we bear in perimenopause and menopause. We can't afford to wing it. And that's why I think this data can be really helpful.” RESOURCES MENTIONED Use code THRIVE15 and get 15% off on your Berkeley Life order https://berkeleylife.pxf.io/Vxvdja Dr. Kristen's Instagram Dr. Kristen's NEW Podcast: Science and Soul Dr. Kristen's Linked In WHOOP Podcast with Kristen Holmes Try WHOOP HERE! RELATED EPISODES #527: The Science Of Energy Production and Recovery & How To Balance Out Cortisol and Melatonin with Kristen Holmes #626: Own Your Morning to Feel Energized and Ready to Show Up for Your Day with Liz Plosser #599: How to Wake Up Feeling Well Rested by Optimizing Sleep & Your Sleep-Wake Cycle with Lynne Peeples 580: Mastering Your Sleep, Metabolism and Overall, Health in Midlife with Cynthia Thurlow
The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human stem-cell-based models using brain endothelial cells are a powerful tool to investigate how disease-related conditions might affect the blood-brain barrier integrity. However, the cell type composition is critical to faithfully model transcytosis across the blood-brain barrier. Our guests today developed a blood-brain model using induced pluripotent stem cells (iPSCs)-derived endothelial cells with brain-specific identity. Using this model they were able to investigate how disease risk factors affect intracellular transport and reveal a new role for ApoE4 in the regulation of iron metabolism at the blood-brain barrier. GuestsRoberto Villaseñor, Principal Scientist and Laboratory Head of the Brain Delivery, Neuroscience and Rare Diseases at the Roche Innovation Center in Basel, Switzerland Martina Pigoni, Senior Discovery Scientist at Roche Innovation Center in Basel, Switzerland HostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationSupporting ContentApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells, Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific DirectorHunter Reed, Senior Marketing Coordinator
Today on the Show Jerry and Lane are joined by Principal Scientist of Forecasting for NIWA - Chris Brandolino and Jerry nerds out over wind...Stay safe out there team! Plus animal attack stories! Eaten by a Pelican?See omnystudio.com/listener for privacy information.
GET OF THE ADVANCED LABS WAITLIST: The first 100 members to tap this link will unlock early access to WHOOP Advanced Labs.**Open the link on the same device as your WHOOP app.This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with two members of the WHOOP Medical Advisory Board and experts on longevity and functional medicine, Dr. Robin Berzin and Dr. Dan Henderson. Dr. Holmes, Dr. Berzin, and Dr. Henderson discuss how the new WHOOP Advanced Labs feature can be a game changer for the future of personalized medicine. The panel unpacks what longevity really means and how to maximize healthspan. Dr. Berzin uses her experience in functional medicine to outline root-cause illness, while Dr. Henderson offers insight on data-driven prevention, lab testing and how behavior change impacts your overall health. The panel dives into the empowerment members will gain from biometric tracking in providing the tools for data collection, self-understanding, and implementing habits to proactively control their health. From insulin sensitivity and metabolic health to inflammation, hormones, and the power building muscle mass, this episode explores the biomarkers that matter most for long-term vitality.(00:00) Introductions: The WHOOP Medical Advisory Board Panel(00:55) What Does “Longevity” Really Mean?(03:00) Biomarkers: The 65 Important Metrics Measured with Advanced Labs(04:42) Understanding The Biomarkers That Matter Most(11:34) Insulin and Glucose: Mastering Your Metabolism(15:28) Women's Health and Hormones: What Biomarkers Matter? (23:26) Behavior Change and Motivation: How To Implement Lifestyle Changes(31:54) What Is Root Cause Medicine?(34:23) Benefits of Functional Medicine(36:17) Looking At Your Body as An Ecosystem(37:12) Navigating Challenges in the Healthcare System(38:32) Empowering Self-Experimentation(40:32) The Future of Preventative Medicine(42:51) Building Muscle For Longevity(47:20) The Role of Wearables in Understanding Your Health(56:05) The Importance of Sleep and Exercise For LongevityDr. Robin Berzin:InstagramFacebookXDr. Dan HendersonLinkedInSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Sign up for WHOOP Advanced Labs Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Kristen Holmes has worn every hat in the world of performance, including athlete, coach, scientist, and innovator.Today, she's setting the standard at WHOOP.At the University of Iowa, she was a two-time First-Team All-American, the 1996 Big Ten MVP, and even pulled double duty on the women's basketball team. From there, she rose to the U.S. National Field Hockey Team, earning a spot as an Olympic alternate in 1996 and competing in the 1998 World Cup.When her playing days concluded, Kristen turned her competitive fire into coaching. From 2003 to 2015, she led Princeton University's field hockey program to a staggering 12 Ivy League titles, 11 NCAA tournament appearances, and the crown jewel of them all, first NCAA field hockey championship by an Ivy League team, in 2012. Then, in 2016, she joined WHOOP, where she's now the Global Head of Human Performance and Principal Scientist. With a Ph.D. in Psychology from the University of Queensland, she's helping athletes, executives, and everyday performers unlock their best through the science of recovery, sleep, and HRV.In just the past few months, Kristen helped launch Project FASTT, a groundbreaking collaboration to close the research gap on female athletes. She's sharing her knowledge on the WHOOP Podcast and Science & Soul.Tap into the Kristen Holmes Special. If you enjoy the podcast, please consider following us on Spotify and Apple Podcasts and giving us a five-star review! I would also appreciate it if you share it with your friend who you think will benefit from it. Comment the word “PODCAST” below and I'll DM you a link to listen. If this episode blesses you, please share it with a friend!S H O W N O T E S-The Run Down By The Running Effect (our new newsletter!): https://tinyurl.com/mr36s9rs-BUY MERCH BEFORE IT'S GONE: https://shop.therunningeffect.run-Our Website: https://therunningeffect.run -THE PODCAST ON YOUTUBE: https://www.youtube.com/channel/UClLcLIDAqmJBTHeyWJx_wFQ-My Instagram: https://www.instagram.com/therunningeffect/?hl=en-Take our podcast survey: https://tinyurl.com/3ua62ffz
The temperature is rising, so are sea levels, and the weather is getting more extreme. So if that iis what the science is showing us, why aren't we adapting more quickly to the risks? That is the question Earth Sciences New Zealand is looking to answer through a new $12 million research programme. Principal Scientist at Earth Sciences New Zealand, Nick Cradock-Henry spoke to Lisa Owen.
In this special Tick Boot Camp Podcast episode recorded live at Project Lab Coat during New York Fashion Week (NYFW), we sit down with Dr. Michal “Mikki” Caspi Tal, Principal Scientist in the Department of Biological Engineering at MIT and Associate Scientific Director of the MIT Center for Gynepathology Research. Dr. Tal is an immunologist and immunoengineer whose groundbreaking research focuses on the connections between infections and chronic diseases, including Lyme disease and long COVID. At her Tal Research Group lab, she studies why some people recover quickly after infection while others develop chronic illness, with a focus on the immune system's different responses in men and women. What You'll Learn in This Episode How Dr. Tal's lab uses mouse models of chronic Lyme and a large clinical study to take a deeper look at Lyme disease. Why some patients make a protective immune response while others develop catastrophic responses like dysautonomia, MCAS, gynecological issues, or clotting disorders. How her team is moving beyond “yes/no” antibody tests to create new biomarker diagnostics that can guide treatments. Why sex differences matter in chronic illness and why women are more likely to experience long-term symptoms after infection. How her research could lead to more personalized treatment approaches for Lyme disease patients by grouping individuals based on immune response patterns. What samples (blood, saliva, sweat, tissue) her team is collecting at MIT to uncover new insights into chronic Lyme disease. Why this research brings hope to Lyme patients who feel unseen and unheard. About Dr. Michal Caspi Tal Principal Scientist, MIT Department of Biological Engineering Associate Scientific Director, MIT Center for Gynepathology Research Focus areas: Lyme disease, long COVID, chronic inflammatory diseases, sex differences in immune response, predictive diagnostics Background: PhD in Immunobiology from Yale (mentored by Dr. Akiko Iwasaki), postdoctoral training at Stanford (Irving Weissman lab), infectious disease research leader at Stanford's Institute for Stem Cell Biology and Regenerative Medicine. Awards: NIH NIAID F31 and F32 Fellowships, Bay Area Lyme Foundation Emerging Leader Award About Project Lab Coat at New York Fashion Week Project Lab Coat was a groundbreaking event held on September 13, 2025, during New York Fashion Week (NYFW). The show brought together prominent celebrities, researchers, doctors, and advocates who were invited to walk the runway to spotlight Lyme disease and raise funds for Lyme disease research. For the first time, the global visibility of NYFW was used to highlight one of the fastest-growing infectious diseases in the world. Tick Boot Camp co-founders Matt Sabatello and Rich Johannesen, together with Dr. Tal, walked the runway at Project Lab Coat, joining leaders from medicine, science, entertainment, and advocacy. Project Lab Coat demonstrated the power of mainstream platforms to bring awareness, credibility, and resources to the fight against Lyme disease. Why This Episode Matters For too long, chronic Lyme patients have been told their symptoms are “all in their head.” Dr. Tal's work at MIT proves otherwise by measuring the real biological differences in immune system responses. This research not only validates patients' experiences but also charts a course toward better diagnostics, clinical trials, and personalized treatments.
This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with women's health expert Dr. Mariza Snyder. Dr. Snyder and Dr. Holmes break down some common misconceptions in peri-menopause and menopause care, and share actionable tools and insights to regain control of your hormones. Dr. Snyder shares her personal journey navigating perimenopause, the warning signs to watch for, and how tracking data with WHOOP can empower women to better understand their bodies. This episode covers everything from cycle tracking and lifestyle habits that can reduce symptoms, to the role of exercise and nutrition, and the impact of alcohol and stress hormones like cortisol. Learn the practical routines for building a symptom-free lifestyle and the baseline knowledge every woman should have by age 30.(00:21) Dr. Snyder's Personal Relationship with Perimenopause and Menopause(03:17) The Warning Signs of Perimenopause(08:21) Role of Data in Understanding Your Body(11:51) Navigating The Healthcare System: Advocating for Perimenopause Treatment(17:31) Finding Solutions to Perimenopause Symptoms(19:15) Starting the Conversation Around Perimenopause Symptoms With Your Partner(22:33) Cycle Tracking: Seeing The Early Signs of Perimenopause(28:34) Easing Symptoms: Incremental Lifestyle Habits To Feel Your Best(36:17) Parenting the Next Generation: Healthy Habits and PCOS Management(42:47) Cortisol-Awakening Response: What Is It and How Can You Test For It?(49:56) Exercise's Role In Symptom Management(01:00:31) Baseline Knowledge For Every Woman To Know By 30(01:04:04) Daily Routines For A Symptom-Free Lifestyle(01:10:03) WHOOP Podcast Rapid Fire Q's(01:11:22) Hormones, Birth Control, & HRT(01:16:12) How Alcohol Is Altering Hormones During Perimenopause(01:27:06) Dr. Snyder's Perimenopause RevolutionFollow Dr. Mariza Snyder:InstagramLinkedInFacebookWebsite The Perimenopause Revolution & BooksSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
The Roundtable Panel: a daily open discussion of issues in the news and beyond. Today's panelists are Biomedical Engineer and Principal Scientist at Regeneron Ahmad Abu-Hakmeh, Former Associate Editor for the Times-Union Mike Spain, and Semi-retired, Editor at large/columnist/editorial writer, Times Union Jay Jochnowitz.
We often talk about the global food crisis as if it's just about climate change, conflicts, or market disruptions. But beneath it all lies a silent, often overlooked driver—gender inequality.From who grows the food, who gets paid for it, who eats first at the dinner table, to who makes decisions about land—gender roles shape every layer of our food systems. And when women and marginalized groups are excluded, the impact ripples far beyond individuals. It weakens food security for entire families, communities, and regions.In this episode, we sit down with Dr. Ranjitha Puskur, Principal Scientist in the Gender and Livelihoods program at the International Rice Research Institute (IRRI). With years of on-the-ground research and policy experience, Dr. Puskur helps us understand why tackling gender inequality is central to solving food insecurity.We explore:• What gender inequality in food systems really looks like in everyday life• Why women—despite producing much of the world's food—are still among the hungriest• How food is distributed within households, and why “who eats first” matters• Local, community-driven actions that can shift entrenched gender roles• Real-world examples where empowering women has strengthened nutrition and food security outcomesIf you're curious about how addressing gender inequality can transform not just households but entire food systems, this conversation will give you fresh, grounded insights.About Nutrition Every Day: A special podcast series by The Good Sight and Rise Against Hunger India, bringing sharp, grounded perspectives on health and nutrition.CreditsHost: Shreya MGuest: Dr. Ranjitha PuskurResearch: Alisha CArtwork: Rajnikant SProduced by: The Good SightConcept: The Good Sight & Rise Against Hunger IndiaFor feedback or to participate, write to us at contact@thegoodsight.org#NutritionEveryDay #GenderEquality #FoodSecurity #SustainableNutrition #TheGoodSight #RiseAgainstHungerIndia #IRRI
This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes, sits down with Chantelle Otten, world-renowned psycho-sexologist, author, and advocate for evidence-based conversations around sexual wellbeing, mental health, and relationships. Chantelle and Dr. Holmes break the taboo around sex in this episode, promoting a more holistic view of sexual health, highlighting the importance of intimacy, desire, and emotional regulation. This episode combines the importance of data and self-awareness, using tools like WHOOP, to support stress management and sleep, and how they contribute to confidence, connection, and satisfaction in and out of the bedroom. 00:27: Chantelle Otten: Psycho-sexology and Why It's Important07:00: WHOOP Podcast Rapid Fire Q's08:20: Importance of Stress and Sleep Management on Your Sexual Health11:30: Unlocking Your Sex Life15:19: Best Practices to Self-Audit: How to Stay Grounded21:21: How to Detect Red Flags In Your Environment24:27: Best Ways To Facilitate Conversations With An Intimate Partner28:36: Creating Safety in Intimacy29:28: Peri-Menopause and Menopause's Effect on Relationships 37:36: Navigating Performance Pressure45:53: The Rules of Curiosity: Responsive and Spontaneous Desire51:23: The Two Key Takeaways That Will Change Your Sex LifeFollow Chantelle Otten:InstagramTiktokWebsiteSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Mikki Tal, PhD, is a Principal Scientist at MIT's Department of Biological Engineering and Associate Scientific Director of the MIT Center for Gynepathology Research. She leads the Tal Research Group, focusing on host-pathogen interactions, immune responses to infections like Lyme disease, and the mechanisms behind chronic illnesses, particularly their disproportionate impact on women. She earned her PhD in Immunobiology from Yale University and conducted postdoctoral research at Stanford University's Institute for Stem Cell Biology and Regenerative Medicine. Tal was the recipient of our 2018 Bay Area Lyme Foundation Emerging Leader Award.
What separates good from great in high-pressure environments? On this episode of the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes, sits down with Rachel Vickery, world-renowned performance consultant. Having spent decades working with elite athletes, military operators, Fortune 500 executives, and emergency physicians, Rachel has cracked the code on understanding and regulating the nervous system to ensure optimal performance when stakes are high. Dr. Holmes and Rachel explore how physiology, behavior, and mindset intersect, and why mastering the nervous system is the key to unlocking peak performance. From breathing mechanics and physiological control, to cultivating curiosity and trust under pressure, this conversation dives deep into the science and skills you need for taking on your next challenge.(00:48) Rachel Vickery on Human Performance(01:41) WHOOP Podcast Rapid Fire Q's (02:50) Essential Breathing Techniques To Use Under Pressure(11:38) Keeping The Body and Mind Calm: What To Do and Why It's Important(15:56) Navigating Fear and Maintaining Positive Self Talk(21:04) How To Train Your Physiology To Aid a Positive Mindset(27:03) Where Data Comes Into Play: Measuring Performance Traits and Habits(34:29) Maintaining a Solid Foundation: High Performance No Matter The Occasion(50:40) Co-regulating: Maintaining Your Cool in a Team Environment(57:10) Advice For Athletes & Coaches: Easing Physiological Effects in a High Pressure Environment(01:11:25) Operating with Trust: How Does This Benefit High Performers?(01:14:57) Learning From Common Traits Relating to Performance AnxietyFollow Rachel Vickery:WebsiteRelated WHOOP Podcast Episodes:Podcast 245: Mental Toughness with Elite Performance Coach Rachel VickeryPodcast 319: Daily Practices to Reset Your Mind, Body, and Identity with Dr. Rangan ChatterjeeResources:Study: 'Cyclic sighing' can help breathe away anxietySupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
What happens to your body—and your behavior—when you start wearing WHOOP every day?In this episode, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes is joined by WHOOP Senior Research Scientist, Dr. Greg Grosicki to break down the results of a groundbreaking new study conducted by WHOOP, analyzing the data from 12,000 WHOOP members over 12 weeks. The study reveals a clear relationship between WHOOP wear frequency and improvements in key health and performance metrics like sleep consistency, duration, and quality, RHR and HRV, and overall physical fitness. Dr. Holmes and Dr. Grosicki break down the study, science, and implications of the findings on long-term health and longevity.The Study:Wearing WHOOP More Frequently Is Associated with Better Biometrics and Healthier Sleep and Activity PatternsRelated Episodes:Understanding GLP-1: The Latest Research From WHOOP with Dr. Greg GrosickiSpotifyAppleYouTubeImproving VO₂ Max For Longevity and Performance with Dr. Greg GrosickiSpotifyAppleYouTubeSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with Dr. Gina Poe, neurobiologist and expert in REM sleep and memory consolidation. Together, Dr. Holmes and Dr. Poe unpack what actually happens when you're asleep and why sleep is essential not just for memory, but emotional resilience, longevity, and high performance. This episode breaks down the different stages of sleep and how they reshape the brain, regulate the nervous system, and actually clean the brain. Dr. Holmes and Dr. Poe provide insight on daily habits to optimize sleep quality, including timing, exercise, and stress regulation.(00:23) Introduction to Dr. Gina Poe(00:58) Dr. Poe's Journey to Sleep Research (06:58) Sleep Timing in Relation to The Body's Physiological Rhythm(12:29) Sleep Pressure and Melatonin Production(14:52) REM Sleep Reshaping the Brain Each Night(21:03) Effects of Short Sleep Cycles (30:17) Relationship Between Skipped Sleep Cycles and Neurodegenerative Disease(31:36) The Importance of Sleep Spindles & Exercise on Sleep Performance(40:46) How Sleep Spindles Change Over A Lifespan(43:44) Daily Practices That Promote Healthy Sleep (49:15) Shift Work, Sleep Cycles, & Human Growth Hormone(55:01) Metabolism and Sleep Cycles: What Happens To The Body's Energy Storage(59:21) Dr. Poe's Dream Sleep Study(01:01:09) What Healthy Sleep Looks Like(01:05:38) Rapid Fire TakeawaysDr. Gina Poe:XRelated Episodes:The Science of Stress & Sleep For Optimal Performance with Dr. Bill von HippelSpotifyAppleYouTubeHow to Sleep Better with Dr. Shelby HarrisSpotifyAppleYouTubeSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Looking to improve your VO₂ Max? This week's episode gives you everything you need to know about one of the latest WHOOP Metrics. WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with WHOOP Senior Research Scientist, Dr. Greg Grosicki to define VO₂ Max and offer insights on its importance for healthspan and human performance. As part of the How To Series, Dr. Grosicki shares his knowledge on how VO₂ Max affects musculoskeletal load, metabolic flexibility and aerobic capacity, and the important training tips to improve this metric. (00:50) How WHOOP Captures VO₂ Max(05:04) Studying VO₂ Max: Creating The Dataset (6:05) Developing The WHOOP VO₂ Max Feature(9:08) How WHOOP Studies VO₂ Max(10:46) Defining VO₂ Max(12:08) Impact of Musculoskeletal Load on VO₂ Max(19:32) The Physiological Factors Determining VO₂ Max(26:07) Inner Ad(26:40) What Is An Optimal VO₂ Max(31:27) Performance and Increasing VO₂ Max(40:13) Metabolic Flexibility(41:39) Training For VO₂ Max(48:16) Quality of Reps As It Relates to VO₂ Max(49:39) Impact of Training ConsistentlyRelated episodes: Paul Larsen - Zone 2 Training:SpotifyAppleSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Dr. Jessica Shepherd returns to the WHOOP Podcast for this month's episode of the How To Series. Dr. Shepherd joins WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes to redefine menopause. Dr. Jessica Shepherd is an OBGYN, menopause expert, and author of Generation M, guiding women through the various stages and lifestyle changes that come with menopause and peri-menopause. Dr. Holmes and Dr. Shepherd bring attention to the symptoms to look out for, create an understanding of the power of early preparation, and establish the importance of strength training and protein intake to support hormonal health. This episode brings to light the need for advocacy in the health space for menopause and peri-menopause care.(00:37) Introducing Dr. Jessica Shepherd(01:14) Reframing Menopause: Dr. Shepherd Personal Mission(03:22) Recognizing The Signs: Symptoms of Perimenopause & Menopause(04:10) Staying Ahead of Symptoms(06:55) What Women in Their 30s Should Know(09:26) Protein & Power: Building Strength for Hormonal Health(12:14) The Positive Role of Daily Activity(15:11) Menopause As A Metabolic Disease(19:12) Lifestyle Changes To Promote Metabolic Health(23:10) Important Biomarkers for Hormonal Health(29:44) Dr. Shepherd's Toolkit For Women with Perimenopause(33:11) Estrogen Creams: Benefits and Practices(36:01) Understanding Hormone Replacement Therapy(39:27) Estrogen's Effects on Cognitive Health, Sleep, & Longevity(42:14) When To Start Taking Estrogen(45:27) The Healthy Choices That Ease Menopause Symptoms(47:57) Birth Control & Peri-Menopause: Detecting Symptoms(51:15) Advocacy for Peri-Menopause and Menopause Care(55:15): Centering Dialogue Around Menopause(01:00:35): The Future of Research in Women's Health(01:05:52): WHOOP as a Tool for Support(01:10:10) Exercise Options to Improve Overall Health(01:11:37) Dr. Shepherd's Closing MessageDr. Jessica Shepherd:WebsiteInstagram LinkedInChanging the Conversation Around Menopause with Dr. Jessica ShepherdSpotifyApple PodcastsYoutubeSupport the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn
Can AI help discover new materials, leading to dramatic breakthroughs in clean energy technologies? In Episode #1 of our deep dive on this topic, host David Sandalow explored the potential for breakthroughs with Taylor Sparks, a professor at the University of Utah and host of the Materialism Podcast, and Colin McCormick, Principal Scientist at Carbon Direct, a professor at Georgetown University and author of the materials innovation chapter in the Artificial Intelligence for Climate Change Mitigation Roadmap (Second Edition). In this episode, David, Taylor and Colin discuss the barriers that must be overcome to realize that potential as well as possible risks. The episode ends with some interesting book recommendations by Taylor and Colin! The AI, Energy and Climate Podcast is a special series from the DSR Network sponsored by NEDO and hosted by David Sandalow, Inaugural Fellow at Columbia University's Center on Global Energy Policy. AI for Climate Change Mitigation Roadmap -- https://www.icef.go.jp/roadmap and transitiondigital.org/ai-climate-roadmap. Learn more about your ad choices. Visit megaphone.fm/adchoices
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