POPULARITY
37 episodes with MSS
34 episodes with MSS
56 episodes with MSS
36 episodes with MSS
18 episodes with MSS
17 episodes with MSS
16 episodes with MSS
12 episodes with MSS
10 episodes with MSS
7 episodes with MSS
6 episodes with MSS
8 episodes with MSS
3 episodes with MSS
4 episodes with MSS
6 episodes with MSS
2 episodes with MSS
3 episodes with MSS
2 episodes with MSS
In this June 2026 episode, MSS intern Cheri Mitchell interviews Tera Hilliard, President and CEO of Forgotten Children, Inc. Tera recounts her journey from foster care to advocacy, shedding light on pressing challenges for youth who age out of foster care such as trafficking, homelessness, and trauma. Forgotten Children, Inc. responds to these needs by providing emergency housing, food, transportation, and case management, focusing especially on vulnerable teens. Tera underscores how mentorship and adult support can transform lives. She talks about the value of community funding, training, and partnerships, advocating for every young person to be met with dignity, respect, and personalized care to nurture true healing and independence.
Social security has been undergoing a quiet revolution across the UK. While attention has focused on the roll-out of Universal Credit, many other aspects of the benefits system are devolved, allowing governments in Wales, Scotland and Northern Ireland to take different approaches to welfare. As newly elected MSs and MSPs prepare to take their seats in the Senedd and the Scottish Parliament, and as the issue of welfare reform continues to loom large over Westminster, understanding what these differences are, and what reforms have worked well, could help to improve the system for everyone. What are the key differences in social security across the four nations of the UK, and is it fair that families may be entitled to very different amounts in different parts of the UK? Which reforms have worked best, and hold lessons for other governments? Should we go further in devolving social security, or does the partially-devolved, partially-reserved nature of social security cause problems for claimants in devolved nations? And what are the wider lessons for welfare reform? The Resolution Foundation hosted an event to debate and answer these questions. Following a presentation of highlights from new research by the Safety Nets project, funded by the Nuffield Foundation and which the Resolution Foundation has contributed to, on social security across the four nations, we will hear from leading experts on what lessons can be learned for further welfare reform.
The new Senedd is underway with new parties, new faces and a lot more MSs. How are the opposition navigating this new landscape? We'll hear from the Welsh leader of Reform and the leader of the Welsh Conservatives. Podcast co-host and former Conservative member and advisor Craig Lawton also joins us in the lounge with Political Correspondent Elliw Gwawr.
In this edition of Between Two Nerds Tom Uren and The Grugq look at Department 4 of Bauman Moscow State Technical University where students learn how to hack for the state. Its curriculum is extremely explicit about how the hacking and propaganda operations are relevant to state operations. They discuss whether this is an advantage for Russia's cyber program and look at what Western intelligence agencies do instead. This episode is also available on YouTube. Show notes The GRU's Hogwarts Vlodymyr Styran's substack BTN92 with Alex Joske, how the MSS became a cyber juggernaut
As the lines between the supplement industry, "biohackers," and medical professionals continue to blur, we with down live at MSS with Dr. Kay Durairaj to discuss why aesthetic providers must lead the charge in evidence-based longevity. We dive deep into the world of peptides—from the safety of GLP-1s to the "wild west" of unregulated research chemicals. Dr. Kay also reveals her latest clinical breakthrough: her "Mid-Face Miracle" for preventing the dreaded "Ozempic Face" by supporting facial fat pads. Whether you're curious about the future of topical anti-aging or worried about the FDA's increasing interest in the med spa space, this episode is a masterclass in staying ahead of the curve while protecting your medical license. The discussion includes: [02:47] The Biohacking Resurgence [04:49] The "Gym Bro" Influence vs. Modern Medicine [06:56] Evidence-Based Medicine and Licensing Risks [12:56] Protecting the Med Spa Reputation [19:12] FDA Outreach and Industry Perception [21:13] Treating Aging as a Disease [25:21] The "Mid-Face Miracle" and Ozempic Face
The Long Munch - Nutrition for Runners, Cyclists & Triathletes
It's been one of the most popular supplements of the last few years. A lot of endurance athletes take collagen regularly, but what is it for, how should it be taken, and is there evidence it lives up to the claims? We're joined by Assistant Prof. Jorn Trommelen, a protein researcher whose lab has done some of the most recent work in this area, to answer our questions. Timestamps: 04:00 - Intro and revisiting Jorn's previous episode (Ep. 73) 12:17 - What is collagen (in the body and as a supplement)? 16:53 - The different types of collagen - does it matter? 22:20 - How did collagen become so popular as a supplement? 30:10 - Why are the supplements always hydrolysed collagen or "collagen peptides"? 31:35 - Fueling Endurance Practitioner Membership, T-12 course for athletes, eBook 33:51 - What are the theoretical reasons for taking collagen supplements? 35:28 - Do you actually need collagen or would any source of these amino acids work? 40:56 - Do you need to take Vitamin C along with collagen? 44:53 - State of scientific evidence for collagen - muscle, tendon, bone tissue. 1:01:57 - Jorn's summary and practical recommendations 1:10:11 - Wrap up Guest - Assistant Prof. Jorn Trommelen - Maastricht University Lab Website: m3-research.nl Research Profile: maastrichtuniversity.nl/j-trommelen Instagram: @nutritiontactics Studies mentioned in this episode: Aussieker T et al. 10.1249/MSS.0000000000003596. Aussieker T et al. The Effects of Ingesting a Single Bolus of Hydrolyzed Collagen versus Free Amino Acids on Muscle Connective Protein Synthesis Rates10.1249/MSS.0000000000003788. Buchalski A et al. Collagen Supplementation on Tendon-Related Structural and Performance Outcomes: A Systematic Review. J Funct Morphol Kinesiol. 2026. 11(1):130. DOI: 10.3390/jfmk11010130 Fueling Endurance eBook | T -12 Race Nutrition Course | Practitioner Resources The Fueling Endurance eBook contains answers to 84 of the most common nutrition questions that runners, cyclists and triathletes ask, and contains insights, tips, and quotes from experts and athletes. The T -12 self-guided course will help prepare you for your next event, with online tools, guides, information and instructions to take you through the 12 weeks leading up to race day. And the Fueling Endurance Practitioner Membership provides access to online tools and calculators I use all the time when working with endurance and ultraendurance athletes. This includes working out the carbohydrate needs for runners (road and trail) and cyclists for different types of training sessions. For more into on each of these, check out fuelingendurance.com.
On today's show Andrew and Bill begin with the news that the Meta-Manus deal will likely be unwound in its entirety in the wake of a ruling from the NDRC on Monday. Topics include: The legal grounding cited by Beijing, reports that Manus failed to seek regulatory approval prior to its relocation and acquisition, Mark Zuckerberg as the photo negative of Tim Cook, Beijing's signal to the AI ecosystem, and why fears of chilled innovation may be slightly overstated. Then: Takeaways from April's Politburo assessing the economy after Q1, including a nod to the Iran war, no signs of stimulus, and why cracking down on involution is easier said than done. At the end: The MSS argues that foreign forces are driving the “lying flat” campaign, while the U.S. quietly applies pressure on a variety of fronts in advance of May's meeting between President Trump and Xi Jinping.
Hip adductor muscle forces during strength training and rehabilitation exercises Collings TJ, Horsman A, Hams AH, et al. Med Sci Sports Exerc. Published online April 3, 2026. doi:10.1249/MSS.0000000000004002 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest VALD MoveHealth - https://movehealth.me/ Learn more about/purchase our courses: The Science PT | Dungeons & Dynamometers Support us on the Patreons! Music for PT Inquest: "The Science of Selling Yourself Short" by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux
Pod Crashing episode 456 with Drake Bennett and Jordan Robertson from The Bloomburg Report's 6th Bureau. It's an open secret that the Chinese government has, for years, engaged in a global campaign to steal intellectual property from Western tech and manufacturing firms. Those stolen secrets have helped Chinese companies, in industry after industry, close the gap and in many cases surpass their competitors elsewhere. And at the center of that campaign is the Ministry of State Security (MSS), China's pre-eminent intelligence agency. The US has apprehended hundreds of people linked to the MSS and its efforts, but its inner workings remained a mystery until one arrest unearthed a trove of confidential documents, covert communications and even a diary. The Sixth Bureau follows Xu Yanjun, the Deputy Division Director of the Sixth Bureau of the Jiangsu Province MSS office. Xu is a burnt-out spy with money problems, a crumbling marriage and a deep resentment for his boss - on a mission to snatch the crown jewel of American aerospace: GE jet engines. With dead drops, cyberattacks, aliases, blackmail and the occasional break-in, Xu played a role in one of the largest economic espionage operations in history, targeting corporate giants like DuPont, Boeing and General Motors. But in the end, his sloppiness - and a cunning FBI sting - led to a stunning reversal: Xu was lured to Belgium, extradited to the US and became the first Chinese intelligence officer ever convicted on American soil. Through undercover recordings, insider accounts and deep reporting, The Sixth Bureau reveals how one man's downfall pulled back the curtain on China's sprawling espionage machine. This isn't just a story about spies: It's about the people caught in the middle of a new kind of cold war.
The future of wellness is moving fast, and med spa owners are feeling the pressure to keep up. In this episode, we are joined by Alex Thiersch, founder and chairman of AmSpa, and Adam Reinebach, CEO of AmSpa, to break down what practices need to know as wellness, aesthetics, and longevity become more connected than ever. With GLP‑1s, peptides, and hormone replacement therapy reshaping the industry, med spa owners are navigating shifting state laws and increasing scrutiny from regulators. Tune in to learn how to manage legal risk, stay compliant amid rapid change, and position your practice for long‑term success in an evolving wellness landscape.Watch full episodes of our podcast on our YouTube channel: https://www.youtube.com/@byrdadattoChapters 00:00 Intro02:05 Banter05:26 Guest Background 08:24 Tell us about AmSpa and MSS.11:36 What trends are you seeing in national med spa legislation?16:00 How is wellness intersecting with aesthetics?21:18 How should med spas approach peptides and HRT? 24:17 What is the future of wellness and aesthetics?26:56 Access+27:44 Legal Takeaways 28:55 OutroStay connected for the latest business and health care legal updates:WebsiteFacebookInstagramLinkedIn
Compensatory movement strategies during the rearfoot elevated split squat after ACL reconstruction Graham M, Gohil A, Janatova T, et al. Med Sci Sports Exerc. Published online February 19, 2026. doi:10.1249/MSS.0000000000003969 The movement variability paper Chris mentioned: https://link.springer.com/article/10.1186/s40798-022-00473-4 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest VALD MoveHealth - https://movehealth.me/ Learn more about/purchase our courses: The Science PT | Dungeons & Dynamometers Support us on the Patreons! Music for PT Inquest: "The Science of Selling Yourself Short" by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux
Pod Crashing episode 456 with Drake Bennett and Jordan Robertson from The Bloomburg Report's 6th Bureau. It's an open secret that the Chinese government has, for years, engaged in a global campaign to steal intellectual property from Western tech and manufacturing firms. Those stolen secrets have helped Chinese companies, in industry after industry, close the gap and in many cases surpass their competitors elsewhere. And at the center of that campaign is the Ministry of State Security (MSS), China's pre-eminent intelligence agency. The US has apprehended hundreds of people linked to the MSS and its efforts, but its inner workings remained a mystery until one arrest unearthed a trove of confidential documents, covert communications and even a diary. The Sixth Bureau follows Xu Yanjun, the Deputy Division Director of the Sixth Bureau of the Jiangsu Province MSS office. Xu is a burnt-out spy with money problems, a crumbling marriage and a deep resentment for his boss - on a mission to snatch the crown jewel of American aerospace: GE jet engines. With dead drops, cyberattacks, aliases, blackmail and the occasional break-in, Xu played a role in one of the largest economic espionage operations in history, targeting corporate giants like DuPont, Boeing and General Motors. But in the end, his sloppiness - and a cunning FBI sting - led to a stunning reversal: Xu was lured to Belgium, extradited to the US and became the first Chinese intelligence officer ever convicted on American soil. Through undercover recordings, insider accounts and deep reporting, The Sixth Bureau reveals how one man's downfall pulled back the curtain on China's sprawling espionage machine. This isn't just a story about spies: It's about the people caught in the middle of a new kind of cold war.Become a supporter of this podcast: https://www.spreaker.com/podcast/arroe-collins-unplugged-totally-uncut--994165/support.
Tijdens de halfuur tussen het opnemen van deze podcast en het publiceren zal D. Trump zijn gedachten tien keer veranderd hebben. Mss is op dit moment de USA in oorlog met Zeeuws-Vlaanderen of zo. Toch doen we allemaal verder en proberen we het beste ervan te maken. Schol!
Im Hochsicherheitstrakt des Oberlandesgerichts Dresden wird im August 2025 ein Mann hereingeführt, den sich viele ganz anders vorgestellt haben. Er hat nichts von James Bond, soll aber genau das sein: Ein Top-Agent, der sensible Informationen abgeschöpft und an den chinesischen Geheimdienst weitergeleitet hat. Jian G. ist angeklagt, weil er jahrelang in ganz unterschiedlichen Bereichen spioniert haben soll – bis hinein ins Herz der europäischen Demokratie: ins EU-Parlament. Jian G. und seine vielfältigen Kontakte lösen einen Spionageskandal aus, wie es ihn so noch nicht gegeben hat. Es ist ein seltener Fall, der einen Einblick gibt in die Arbeit und Taktik eines der mutmaßlich größten Geheimdienste der Welt: des chinesischen Ministeriums für Staatssicherheit, MSS. Doch Jian G. fliegt auf, wird im April 2024 festgenommen und später vor Gericht gestellt. Ein mutmaßlicher chinesischer Spion, über Jahre mit eigenem Büro im Europäischen Parlament, mit Zugang zu allen möglichen Sitzungen und Dokumenten. Ging es vor allem um das Abschöpfen von Informationen? Oder auch um Einflussnahme, vielleicht sogar um Sabotage? „Dark Matters – Geheimnisse der Geheimdienste“ erzählt die Geschichte eines besonderen Spionageskandals. Eine Geschichte über das leise, unauffällige Handeln eines Einzelnen, der gigantisch viele Daten gesammelt und übermittelt haben soll. Wenn ihr mehr darüber erfahren wollt, welche Schwerpunkte der chinesische Geheimdienst im Ausland setzt, hört die begleitende Hintergrundfolge: „Wie läuft Chinas Wirtschaftsspionage ab?”. Und das ist „Dark Matters”: Eva-Maria Lemke öffnet im Podcast die Tür zu einer Welt, die eigentlich im Verborgenen bleiben soll – Woche für Woche mit einer neuen Geschichte, die zeigt, wie Nachrichtendienste arbeiten. In der vierten Staffel geht es um eine neue Zeit, in der alte Fragen von Krieg und Frieden, von Verbündeten und Feinden nicht mehr eindeutig zu beantworten sind. Wie stellen sich Staaten, Dienste und Agenten darauf ein? Die ARD-Geheimdienstexperten Michael Götschenberg und Holger Schmidt geben Antworten. Eine neue Folge „Dark Matters – Geheimnisse der Geheimdienste” gibt es mittwochs – immer zuerst in der ARD Sounds App. Und noch ein Tipp zum Weiterhören: Wenn euch weitere Geschichten aus dem Reich der Mitte interessieren: In „Welt.Macht.China“ berichten aktive und ehemalige ARD-Korrespondenten und Expertinnen aus dem Land und über das Land – und sie räumen nebenbei auch mit ein paar Klischees auf. „Welt.Macht.China“ gibt‘s unter anderem in der ARD Sounds App. https://www.ardaudiothek.de/sendung/welt-macht-china/10494211/
In Episode 6 of The Sixth Bureau, a series from The Big Take, with spy Xu Yanjun in prison, the US government pursues some of his collaborators. Plus, host Jordan Robertson gets an unexpected call which leads to a big discovery. The Sixth Bureau from Bloomberg News follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness — and a cunning FBI sting — led to a stunning reversal: Xu Yanjun became the first Chinese intelligence officer ever convicted on American soil. The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. Listen to Episodes 1 - 5 here.See omnystudio.com/listener for privacy information.
In Episode 6 of The Sixth Bureau, a series from The Big Take, with spy Xu Yanjun in prison, the US government pursues some of his collaborators. Plus, host Jordan Robertson gets an unexpected call which leads to a big discovery. The Sixth Bureau from Bloomberg News follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness — and a cunning FBI sting — led to a stunning reversal: Xu Yanjun became the first Chinese intelligence officer ever convicted on American soil. The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. Listen to Episodes 1 - 5 here.See omnystudio.com/listener for privacy information.
In Episode 5 of The Sixth Bureau, a series from The Big Take, a spy from China’s Ministry of State Security travels to an overseas meeting with a valuable source. He has no idea he is walking into a trap that the FBI has been setting up for months. The Sixth Bureau from Bloomberg News follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness — and a cunning FBI sting — led to a stunning reversal: Xu Yanjun became the first Chinese intelligence officer ever convicted on American soil.The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. Listen to Episodes 1 - 4 here.See omnystudio.com/listener for privacy information.
In this installment of Making Sense of Space, we take a deeper dive into satcom discussing the evolution of the industry, market dynamics, emergence of LEO mega constellations, MSS spectrum, D2D/DTC, and future growth areas with Matt Desch, CEO of Iridium
In Episode 4 of The Sixth Bureau, a series from The Big Take, we follow a spy from China’s Ministry of State Security as he tries to plan a delicate overseas meeting with a valuable source. But the person he’s talking to isn’t working alone. The Sixth Bureau from Bloomberg News follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness — and a cunning FBI sting — led to a stunning reversal: Xu Yanjun became the first Chinese intelligence officer ever convicted on American soil. The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. Listen to Episodes 1 - 3 here.See omnystudio.com/listener for privacy information.
Featuring an interview with Dr Stacey A Cohen, Dr Arvind Dasari and Dr Christopher Lieu, including the following topics: Biological Principles Underlying Circulating Tumor DNA (ctDNA) Molecular Residual Disease (MRD) Testing in Colorectal Cancer (CRC) — Dr Cohen (0:00) Potential Utility of ctDNA Testing to Identify Patients with Localized CRC Who Might Benefit from Treatment De-escalation or Escalation — Dr Lieu (17:44) Role of ctDNA Analysis in the Management of Metastatic CRC – Dr Dasari (36:16) Clinical Investigator Survey Results (56:06) Case: A woman in her early 40s with mismatch repair-proficient/microsatellite-stable (MSS), low-risk Stage II colon cancer — Dr Lieu (1:23:05) Case: A woman in her early 70s with microsatellite instability-high Stage III colon cancer with a BRAF mutation — Dr Cohen (1:26:06) Case: A man in his mid 40s with metastatic CRC — Dr Dasari (1:31:57) Case: A man in his early 50s with low-risk Stage III colon cancer — Dr Lieu (1:37:54) Case: A man in his early 30s with MSS, high-risk Stage II CRC — Dr Cohen (1:50:17) Case: A woman in her early 50s with metastatic CRC — Dr Dasari (1:52:05) Case: A man in his early 60s with Stage IV colon cancer — Dr Lieu (1:56:05) CME information and select publications
It's an open secret that the Chinese government has, for years, engaged in a global campaign to steal intellectual property from Western tech and manufacturing firms. Those stolen secrets have helped Chinese companies, in industry after industry, close the gap and in many cases surpass their competitors elsewhere. And at the center of that campaign is the Ministry of State Security (MSS), China's pre-eminent intelligence agency. The US has apprehended hundreds of people linked to the MSS and its efforts, but its inner workings remained a mystery until one arrest unearthed a trove of confidential documents, covert communications and even a diary.The Sixth Bureau follows Xu Yanjun, the Deputy Division Director of the Sixth Bureau of the Jiangsu Province MSS office. Xu is a burnt-out spy with money problems, a crumbling marriage and a deep resentment for his boss - on a mission to snatch the crown jewel of American aerospace: GE jet engines. With dead drops, cyberattacks, aliases, blackmail and the occasional break-in, Xu played a role in one of the largest economic espionage operations in history, targeting corporate giants like DuPont, Boeing and General Motors. But in the end, his sloppiness - and a cunning FBI sting - led to a stunning reversal: Xu was lured to Belgium, extradited to the US and became the first Chinese intelligence officer ever convicted on American soil.Through undercover recordings, insider accounts and deep reporting, The Sixth Bureau reveals how one man's downfall pulled back the curtain on China's sprawling espionage machine. This isn't just a story about spies: It's about the people caught in the middle of a new kind of cold war.Become a supporter of this podcast: https://www.spreaker.com/podcast/arroe-collins-like-it-s-live--4113802/support.
In Episode 3 of The Sixth Bureau, a series from The Big Take, we follow a spy from China’s Ministry of State Security to the Paris Air Show, and then watch him develop a valuable source, despite his bosses constantly getting in his way. The Sixth Bureau from Bloomberg News follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness — and a cunning FBI sting — led to a stunning reversal: Xu Yanj un became the first Chinese intelligence officer ever convicted on American soil. The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. Listen to Episode 1 and 2 here. See omnystudio.com/listener for privacy information.
It’s an open secret that the Chinese government has engaged in a global campaign to acquire intellectual property from foreign rivals. At the center of that campaign is the Ministry of State Security, China’s elusive intelligence agency. The US has apprehended hundreds of people accused of giving information to the MSS, but the agency’s inner workings have been a mystery – until now. The Sixth Bureau from Bloomberg News follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness – and a cunning FBI sting – led to a stunning reversal: Xu Yanjun became the first Chinese intelligence officer ever convicted on American soil. The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. Listen to episodes 1 and 2 now on Bloomberg's Big Take podcast.See omnystudio.com/listener for privacy information.
It’s an open secret that the Chinese government has engaged in a global campaign to acquire intellectual property from foreign rivals. At the center of that campaign is the Ministry of State Security, China’s elusive intelligence agency. The US has apprehended hundreds of people accused of giving information to the MSS, but the agency’s inner workings have been a mystery — until now. Today, we’re bringing you Episode 1 of The Sixth Bureau, a limited-run series from The Big Take. The series follows an MSS intelligence officer whose mission was to acquire the crown jewels of American aerospace companies. With aliases, blackmail and the occasional break-in, he targeted corporate giants. That is, until his sloppiness — and a cunning FBI sting — led to a stunning reversal: Xu Yanjun became the first Chinese intelligence officer ever convicted on American soil. The Sixth Bureau is the story of superpowers, their secrets and how one Chinese spy got caught. This limited-run series will publish on Fridays in The Big Take. See omnystudio.com/listener for privacy information.
In this February 2026 episode, MSS intern Cheri Mitchell interviews Maddy Day, Proprietor and Senior Consultant of Maddy Day, LLC & Associates, and co-Founder and co-Chair of FAAN (Fostering Academic Achievement Nationwide). Influenced by her family's deep ties to child welfare, Maddy gained early insight into the realities facing non‑traditional families. Her career path ultimately led to the creation of FAAN in 2016, a network that grew from informal cross‑state conversations among practitioners that now includes more than twenty states. Maddy's journey and FAAN's expansion underscore the impact of connection, reliable data, persistent advocacy, and the importance of listening to students in creating equitable educational pathways for youth with experience in foster care.
The FT's George Parker and strategic communications consultant Dafydd Rees joins us to talk all about Prime Minister Sir Keir Starmer's nightmare week and future prospects. Newly minted Reform MS James Evans is in the studio. Cymorth Cymru's Katie Dalton explains the importance of MS voting on amendments after some MSs non-appearance at the Homelessness Bill's vote. Chief Executive of the Patient's association Rachel Power discusses the challenges posed by cross-border health services. Author Glen O'Hara discusses his new book, New Labour, New Britain?Reform's Joseph Martin and comedian Esyllt Sears review the papers.
MSS is the biggest show of the year, every year. It's not easy to tame a beast of that size, but attendees will let you know that it is worth it. This week, AmSpa founder Alex R. Thiersch, JD, sits down with AmSpa Director of Education Kirstie Jackson to preview what's coming at Medical Spa Show 2026 (April 9–12 at Wynn Las Vegas)—and how the agenda is built to serve everyone from newcomers to advanced operators. Kirstie breaks down how she uses data and problem-solving to sift through over 450 presentation submissions, the brand-new learning formats attendees have been asking for, and the can't miss learning opportunities—including an AI summit, our industry-defining cadaver course, and live injections making their debut at MSS. For more information, visit https://www.medicalspashow.com/ Discussion Points Include The size and scope of the Medical Spa Show, spanning eight tracks of education How the AmSpa team creates an elevated immersive experience Creating a speaker lineup that balances the biggest names with exciting new voices New features of the MSS App that attendees will love A preview of the MSS agenda, from returning favorites to bold new topics including regenerative medicine and artificial intelligence Turning MSS into a four-day experience The exciting news about MSS featuring live injections
In this January 2026 episode, MSS intern Cheri Mitchell interviews Zach Blend, Chief Executive Officer of the Goshen Valley Foundation located in Cherokee County, GA. Zach shares his child welfare wisdom and experiences caring for youth in foster care as they prepare to age out of the system. Goshen New Beginnings, an independent living program on Goshen Valley's campus, plays an integral part in this transition to adulthood. The program enables young people to continue their time in care until age 21, helps them develop relational confidence to connect with adult supports in a healthy and trustworthy way, and provides opportunities to learn the skills of daily living.
The Pentagon is looking to launch a new Enterprise Command and Control Program Office in a move that would consolidate and refresh its long-standing efforts to provide common operating panes and user-specific AI tools to track and target enemies in real time. This envisioned hub would combine and expand the Chief Digital and Artificial Intelligence Office's Maven Smart System (MSS) and Edge Data Mesh capabilities into the “Enterprise C2 Suite” — a new platform and program of record for Combined Joint All-Domain Command and Control and Al-enabled warfighting options, according to sources familiar with the plan who requested anonymity to discuss it ahead of a forthcoming, official announcement. Internal guidance regarding a new EC2 Program Office suggests that its establishment would ensure that the Defense Department has the “authority, resources, and accountability to deliver capability at the speed of relevance.” DOD's undersecretariats for Intelligence and Security (I&S) and Research and Engineering (R&E) would be directed to deliver a plan for “the expedient transition of MSS authorities, infrastructure, support activities, and responsibilities” from the National Geospatial-Intelligence Agency to the EC2 Program Office. This new program office would essentially fuse multiple Pentagon elements that have come to fruition since the late 2010s, and are associated with digitizing command-and-control processes and deploying AI across the joint force. The Defense Department is soliciting ideas for how artificial intelligence and machine learning capabilities can assist in the zero-trust assessment process as the deadline to reach target-level compliance approaches. According to a request for information posted Tuesday, the DOD's Zero Trust Portfolio Management Office is interested in leveraging “automation, AI and ML to accelerate and scale [zero trust] assessments” across the entire department — specifically for “purple team assessments.” The technologies will help the Pentagon mitigate its limited capacity to validate initial compliance and conduct continuous assessments, the RFI noted. Zero trust is a cybersecurity concept that assumes IT networks and systems are constantly under attack by adversaries, requiring the Pentagon to continuously monitor and authenticate users and their devices as they move through the network. The department's Zero Trust Strategy mandates all DOD components to achieve “target levels” of zero trust by the end of fiscal 2027. Validating compliance requires a combination of internal and third-party assessments. A key part of the Pentagon's independent evaluation process is a method called purple teaming, which analyzes and tests both how “red team” adversaries and “blue force” cyber defenders move and interact in an IT network. However, officials have previously noted that conducting comprehensive purple teaming can be a time-consuming process that can take warfighters away from other important missions. The Daily Scoop Podcast is available every Monday-Friday afternoon. If you want to hear more of the latest from Washington, subscribe to The Daily Scoop Podcast on Apple Podcasts, Soundcloud, Spotify and YouTube.
PolicyTracker journalists Cameron Hill and Laura Sear discuss the three most pressing and controversial issues in the long run-up to WRC-27. They tackle unauthorised satellite transmissions, new IMT bands and the topic of MSS in IMT bands - as well as introducing WRC-27 and explaining its processes.
On today's show Andrew and Bill begin with the news that the US is greenlighting the sale of Nvidia's H200 chips to the PRC market. Topics include: Dubious claims in Trump's Truth Social post announcing the news, searching for arguments in support of this policy change, the 25% of China revenue Nvidia will pay to the U.S. government, and waiting for Beijing's response, including how many U.S. chips Chinese companies will be allowed to buy. From there: The U.S. halts plans to sanction the MSS and its contractors, Japan seeks more support from the U.S., and the dynamics of “stability” come into focus. At the end: The December Politburo meeting, Emmanuel Macron's visit to China, an email about the West's willingness to build, and ‘Zootopia 2' becomes a sensation in China.
The treatment for locally advanced rectal cancer has undergone numerous changes and is now used routinely in clinical practice. Please join us in a thorough discussion of current evidence and ongoing research of total neoadjuvant therapy in locally advanced rectal cancer with leaders in the field including Drs J. Joshua Smith, Julio Garcia-Aguilar, Emmanouil Fokas, and Benjamin Schlechter Hosts: · Dr. Janet Alvarez - General Surgery Resident at New York Medical College/Metropolitan Hospital Center · Dr. Wini Zambare – General Surgery Resident at Weill Cornell Medical Center/New York Presbyterian · Dr. Phil Bauer, Graduating Colorectal Surgical Oncology Fellow at Memorial Sloan Kettering Cancer Center · Dr. J. Joshua Smith MD, PhD, Chair, Department of Colon and Rectal Surgery at MD Anderson Cancer Center Guests: 1. Julio Garcia-Aguilar, MD, PhD Benno C. Schmidt Chair in Surgical Oncology Chief, Colorectal Service, Department of Surgery Director, Colorectal Cancer Research Center, Memorial Sloan Kettering Cancer Center Professor of Surgery, Weill Cornell Medical College 2. Benjamin Schlechter, MD Senior Physician in the Gastrointestinal Cancer Center at the Dana-Farber Cancer Institute Assistant Professor of Medicine, Medicine, Harvard Medical School 3. Emmanouil Fokas, MD, DPhil Professor and Chairman | Department of Radiation Oncology, Cyberknife and Radiotherapy | Faculty of Medicine, University Hospital Cologne Learning objectives: · Define locally advanced rectal cancer (LARC) and describe the clinical staging that qualifies patients for total neoadjuvant therapy (TNT). · Explain the rationale for transitioning from traditional chemoradiotherapy (CRT) plus surgery to total neoadjuvant therapy in rectal cancer management. · Compare the designs, treatment regimens, and long-term outcomes of major TNT trials including RAPIDO, PRODIGE-23, OPRA, and CAO/ARO/AIO-12/16. · Evaluate organ preservation strategies—such as the watch-and-wait approach—after TNT and identify which patients are appropriate candidates based on clinical or near-complete response. · Summarize emerging research directions including: · Integration of circulating tumor DNA (ctDNA) in surveillance and response prediction. · The role of immunotherapy in mismatch repair proficient (MSS) and deficient (dMMR) tumors. References: 1. Garcia-Aguilar, J. et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. JCO 40, 2546–2556 (2022). https://pubmed.ncbi.nlm.nih.gov/35483010/ 2. Verheij, F. S. et al.Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial. JCO 42, 500–506 (2024). https://pubmed.ncbi.nlm.nih.gov/37883738/ 3. Fokas, E. et al. Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12. JCO 37, 3212–3222 (2019). https://pubmed.ncbi.nlm.nih.gov/31150315/ 4. Fokas, E. et al. Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial. JAMA Oncol 8, e215445–e215445 (2022). https://pubmed.ncbi.nlm.nih.gov/34792531/ 5. Williams H*, Fokas E*, et al. Survival among patients treated with total mesorectal excision or selective watch-and-wait after total neoadjuvant therapy: a pooled analysis of the CAO/ARO/AIO-12 and OPRA randomized phase II trials. Ann Oncol 2025 May;36(5):543-547. https://pubmed.ncbi.nlm.nih.gov/39848335/ 6. Gani, C. et al. Organ preservation after total neoadjuvant therapy for locally advanced rectal cancer (CAO/ARO/AIO-16): an open-label, multicentre, single-arm, phase 2 trial. The Lancet Gastroenterology & Hepatology 10, 562–572 (2025). https://pubmed.ncbi.nlm.nih.gov/40347958/ Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US
Kevin Freeman and former CIA officer Sam Faddis outline how China's “unrestricted warfare” strategy targets undersea internet cables, cellular networks via SIM farms, and satellites to paralyze U.S. communications and commerce. They warn that 99% of global data flows through vulnerable subsea cables, now threatened by specialized Chinese vessels and ROVs capable of deepwater cuts — actions tantamount to acts of war. Recent SIM farm busts near the U.N. highlight MSS-run operations capable of jamming 911, conducting fraud, and launching denial-of-service attacks with off-the-shelf gear. The discussion urges rapid decoupling from Chinese-made critical components, hardening the grid, rebuilding U.S. industrial capability, and reorienting investments to strengthen national resilience.
In this October 2025 episode, MSS intern Cheri Mitchell interviews Sarah Pauter, Executive Director of John Burton Advocates for Youth (JBAY). Sarah shares how her lived experience in foster care motivated her to become an outspoken advocate for extending the age of foster care emancipation to twenty-one. She passionately advocated for the passing of Assembly Bill 12 (AB 12) which became law in 2010, creating California's Extended Foster Care (EFC) Program. At JBAY, Sarah continued her advocacy by establishing support programs for students with foster care experience on every public post-secondary campus in the state of California. To date, JBAY has championed over fifty-five legislative reforms and secured $3.6 billion in new state and federal investments for youth in foster care or experiencing homelessness.
JCO PO author Dr. Asaf Maoz at Dana-Farber Cancer Institute shares insights into article, “Causes of Death Among Individuals with Lynch Syndrome in the Immunotherapy Era.” Host Dr. Rafeh Naqash and Dr. Maoz discuss the causes of death in individuals with LS and the evolving role of immunotherapy. TRANSCRIPT Dr. Rafeh Naqash: Hello, and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant JCOPO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Associate Professor Medicine, at the OU Health Stephenson Cancer Center. Today, I'm super thrilled to be joined by Dr. Asaf Maoz, Medical Oncologist at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and faculty at the Harvard Medical School, and also lead author on the JCO Precision Oncology article entitled "Causes of Death Among Individuals with Lynch Syndrome in the Immunotherapy Era." This publication will be a concurrent publication with an oral presentation at the annual CGA meeting. At the time of this recording, our guest's disclosures will be linked in the transcript. Asaf, I'm excited to welcome you on this podcast. Thank you for joining us today. Dr. Asaf Maoz: Thank you so much for highlighting our paper. Dr. Rafeh Naqash: Absolutely. And I was just talking to you that we met several years back when you were a trainee, and it looks like you've worked a lot in this field now, and it's very exciting to see that you consider JCOPO as a relevant home for some of your work. And the topic that you have published on is of significant interest to trainees from a precision medicine standpoint, to oncologists in general, covers a lot of aspects of immunotherapy. So, I'm really excited to talk to you about all of this. Dr. Asaf Maoz: Me too, me too. And yeah, I think JCOPO has great content in the area of cancer genetics and has done a lot to disseminate the knowledge in that area. Dr. Rafeh Naqash: Wonderful. So, let's get started and start off, given that we have hosts of different kinds of individuals who listen to this podcast, especially when driving from home to work or back, for the sake of making everything simple, can we start by asking you what is Lynch syndrome? How is it diagnosed? What are some of the main things to consider when you're trying to talk an individual where you suspect Lynch syndrome? Dr. Asaf Maoz: Lynch syndrome is an inherited predisposition to cancer, and it is common. So, we used to think that, or there's a general notion in the medical community that it is a rare condition, but we actually know now from multiple studies, including studies that look at the general population and do genetic testing regardless of any clinical phenotype, that Lynch syndrome is found in about 1 in 300 people in the general population. If you think about it in the United States, that means that there are over a million people living with Lynch syndrome in the United States. Unfortunately, most individuals with Lynch syndrome don't know they have Lynch syndrome at the current time, and that's where a lot of the efforts in the community are being made to help detect more individuals who have Lynch syndrome. Lynch syndrome is caused by pathogenic germline variants in mismatch repair genes, MLH1, MSH2, MSH6, or PMS2, or as a result of pathogenic variants in EPCAM that cause silencing of the MSH2 gene. Dr. Rafeh Naqash: Excellent. Thank you for that explanation. Now, one of the other things I also realized, similar to BRCA germline mutations, where you require a second hit for individuals with Lynch syndrome to have mismatch repair deficient cancers, you also require a second hit to have that second hit result in an MSI-high cancer. Could you help us understand the difference of these two concepts where generally Lynch syndrome is thought of to be cancers that are mismatch repair deficient, but that's not necessarily true for all cases as we see in your paper. Can you tease this out for us a little bit more? Dr. Asaf Maoz: Of course, of course. So, the germline defect is in one of the mismatch repair genes, and these genes are responsible for DNA mismatch repair, as their name implies. Now, in a normal cell, we think that one working copy is generally enough to maintain the mismatch repair machinery intact. What happens in tumors, as you alluded to, is that there is a second hit in the same mismatch repair gene that has the pathogenic germline variant, and that causes the mismatch repair machinery not to work anymore. And so what happens is that there is formation of mutations in the cancer cell that are not present in other cells in the body. And we know that there are specific types of mutations that are associated with defects in mismatch repair mechanisms, and those are associated a lot of times with frameshift mutations. And we have termed them ‘microsatellites'. So there are areas in the genome that have repeats, for example, you know, if you have AAAA or GAGA, and those areas are particularly susceptible to mutations when the mismatch repair machinery is not working. And so we can measure that with DNA microsatellite instability testing. But we can also get a sense of whether the mismatch repair machinery is functioning by looking at protein expression on the surface of cancer cells and by doing immunohistochemistry. More recently, we're also able to infer whether the mismatch repair machinery is working by doing next-generation sequencing and looking at many, many microsatellites and whether they have this DNA instability in the microsatellites. Dr. Rafeh Naqash: Excellent explanation. As a segue to what you just mentioned, and this reminds me of some work that one of my good friends, collaborators, Amin Nassar, whom you also know, I believe, had done a year and a half back, was published in Cancer Cell as a brief report, I believe, where the concept was that when you look at these mismatch repair deficient cancers, there is a difference between NGS testing, IHC testing, and maybe to some extent, PCR testing, where you can have discordances. Have you seen that in your clinical experience? What are some of your thoughts there? And if a trainee were to ask, what would be the gold standard to test individuals where you suspect mismatch repair deficient-related Lynch syndrome cancers? How would you test those individuals? Dr. Asaf Maoz: We do sometimes see discordance, you know, from large series, the concordance rate is very high, and in most series it's over 95%. And so from a practical perspective, if we're thinking about the recommendation to screen all colorectal cancer and all endometrial cancer for mismatch repair deficiency, I think either PCR-based testing or immunohistochemistry is acceptable because the concordance rate is very high. There are rare cases where it is not concordant, doing multiple of the tests makes sense at that time. If you think about the difference between the tests, the immunohistochemistry looks at protein expression, which is a surrogate for whether there is mismatch repair deficiency or not, right? Because ultimately, the mismatch repair deficiency is manifested in the mutations. So if the PCR does not show microsatellite instability and now NGS does not show microsatellite instability, the IHC may be a false positive. At the end of the day, the functional analysis of whether there are actually unstable microsatellites either by PCR or by NGS is what I would consider more informative. But IHC again is an excellent test and concordant with those results in over 95% of cases. Now there is also an issue of sampling. It's possible that there's heterogeneity within the tumor. We published a case in JCOPO about heterogeneity of the mismatch repair status, and that was both by immunohistochemistry, but also by PCR. So there are some caveats and interpreting these tests does require some expertise, and I'm always happy to chat with trainees or whoever has an interesting or challenging case. Dr. Rafeh Naqash: Thanks again for that very easy to understand explanation. Now going to management strategies, could you elaborate a little bit upon the neo-adjuvant data currently, or the metastatic data which I think more people are familiar with for immunotherapy in individuals with MSI-high cancers? Dr. Asaf Maoz: Yeah, that's an excellent question and obviously a very broad topic. Individuals with Lynch syndrome typically develop tumors that are mismatch repair deficient or microsatellite unstable. And we have seen over the last 15 years or so that these tumors, because they have a lot of mutations and because these mutations are very immunogenic, we have seen that they respond very well to immunotherapy. And this has been shown across disease sites and has been shown across disease settings. And for that reason, immunotherapy was approved for MSI-high or mismatch repair deficient cancer regardless of the anatomic site. It was the first tissue-agnostic approval by the FDA in 2017. And so there are exciting studies both in the metastatic setting where we see individuals who respond to immunotherapy for many years, and one could wonder whether their cancer is going to come back or not. And also in the earlier setting, for example, the Cercek et al. study in the New England Journal from Sloan Kettering, where they showed that neoadjuvant immunotherapy can cause durable responses for rectal cancer that is mismatch repair deficient. And in that series, the patients did not require surgery or radiation, which is standard of care for rectal cancer otherwise. And there's also exciting data in the adjuvant space, as was presented in ASCO by Dr. Sinicrope, the ATOMIC study, and many more efforts to bring immunotherapy into the treatment landscape for individuals with MSI-high cancer, including individuals with Lynch syndrome. Dr. Rafeh Naqash: A lot of activity, especially in the neo-adjuvant and adjuvant space over the last two years or so. Now going to the actual reason why we are here is your study. Could you tell us why you looked at this idea of patients who had Lynch syndrome and died, and the reasons for their death? What was the thought that triggered this project? Dr. Asaf Maoz: As we were talking about, we now know that immunotherapy really has changed the treatment landscape for individuals with Lynch syndrome, and that most cancers that individuals with Lynch syndrome do have this mismatch repair deficiency. But we also know that individuals with Lynch syndrome can develop tumors that do not have mismatch repair deficiency, and we call them mismatch repair proficient or microsatellite stable. And there was a series from Memorial Sloan Kettering showing that in colorectal cancer, about 10% of the tumors that individuals with Lynch syndrome developed did not have mismatch repair deficiency. In addition to that, we anecdotally saw that some of our patients with Lynch syndrome died of causes that were not mismatch repair deficient tumors. We wanted to see how that has changed since immunotherapy was approved in a tissue-agnostic manner, meaning that we could look at this regardless of where the cancer started, because we would anticipate that if the tumor was mismatch repair deficient, the patient would be able to access immunotherapy as standard of care. Dr. Rafeh Naqash: Thank you. And then you looked at different aspects of correlations with regards to individuals that had an MSI-high cancer with Lynch syndrome or an MSS cancer with Lynch syndrome. Could you elaborate on some of the important findings that you identified as well as some of the unusual findings that perhaps we did not know about, even though the sample size is limited, but what were some of the unique things that you did identify through this project? Dr. Asaf Maoz: The first question was what cause is leading to death in individuals with Lynch syndrome? And we had 54 patients that we identified that had died since the approval of immunotherapy in 2017, 44 of which died of cancer-related causes. And when we looked at cancer-related causes of death, we wanted to know how many of those were due to mismatch repair deficient tumors versus mismatch repair proficient tumors or MS-stable tumors. And we found, somewhat surprisingly, that 43% of patients in our cohort actually died of tumors that were microsatellite stable or mismatch repair proficient, meaning of tumors that are not typically associated with Lynch syndrome. This is not entirely surprising as a cause of death because we know that immunotherapy does not typically work for tumors that are microsatellite stable. And so in the metastatic setting, there are much less cases of durable remissions with treatment. But it was helpful to have that figure as an important benchmark. There are previous studies about causes of death in Lynch syndrome, and particularly from the Prospective Lynch Syndrome Database in Europe. Those have provided really important information about cause of death by cancer site, but they typically don't have mismatch repair status and are more difficult to interpret in that regard. They also don't include a large number of individuals who have PMS2 Lynch syndrome, which is the most common, but least penetrant form of Lynch syndrome. Dr. Rafeh Naqash: As far as the subtype of pathogenic germline variants is concerned, did you notice anything unusual? And I've always had this question, and you may know more about this data, is: In the bigger context of immunotherapy, does the type of the pathogenic germline variant for Lynch syndrome associated MSI-high cancers, does that impact or have an association with the kind of outcomes, how soon a cancer progresses or how many exceptional responders perhaps with MSI-high cancers actually have a certain specific pathogenic germline variant? Dr. Asaf Maoz: That's an excellent question, and certainly we need more data in that space. We know that the type of germline mutation, or the gene in which there is a germline pathogenic variant, determines to a large degree the cancer risk, right? So we know that individuals who have germline pathogenic variants in MLH1 or MSH2 have a much higher colorectal cancer risk than, for example, PMS2. We know that for PMS2, the risks are more limited to colorectal and endometrial, and may be lower risk of other cancers. We also know that, you know, the spectrum of disease may change based on the pathogenic germline variants. For example, individuals who have MSH2 associated Lynch syndrome have more risk of additional cancers in other organs like the urinary tract and other less common Lynch-associated tumors. The question about response to therapy is one where we have much less information. There are studies that are trying to assess this, but I don't think the answer is there yet. Some of the non-clinical data looks at how many mutations there are based on the pathogenic variant and what the nature of those mutations are, whether they're more frameshift or others. But I think we still need more clinical data to understand whether the response to immunotherapy differs. It's also complicated by the fact that the immunotherapy landscape is changing, especially in the metastatic setting, now with the approval of combination ipilimumab and nivolumab for first-line treatment of colorectal cancer that is microsatellite unstable. But in our study, we did find that, as you would expect, there is an enrichment in MS-stable cancers among those with PMS2 Lynch syndrome. Again, our denominator is those who died, right? So this is not the best way to look at the question whether this is overall true, that is more addressed by the study that Sloan Kettering published. But we do see, as we would anticipate, that there are more microsatellite stable cancers among those with PMS2 Lynch syndrome that died. Dr. Rafeh Naqash: A lot to uncover there for sure. This study and perhaps some of the other work that you're doing is slowly advancing our understanding of some of these concepts. So I'd like to shift gears to a couple of provocative questions that I generally like to ask. The first is, in your opinion, and you may or may not have data to back this up, which is okay, and that's why we're having a conversation about it. In your opinion, do you think the type or the quality of the neoantigen is different based on the pathogenic germline variant and a Lynch syndrome associated MSI-high cancer? Dr. Asaf Maoz: I think there are some data out there that, you know, I can't cite off the top of my mind, but there are some data out there that suggest that that may be the case. I think the key question is the quality, right? I think that whether these differences that are found on a molecular level also translate to a clinical difference in response is something that is unknown at this moment. Some people hypothesize that if the tumor has less neoantigens, there's less of a response to immunotherapy. But I think we really need to be careful before making those assertions on a clinical level. I do think it's a really important question that needs to be answered, among others because, you know, in the colorectal space, for example, where we have both the option of doing ipilimumab with nivolumab and the option of doing pembrolizumab, we don't really know which patients need the CTLA-4 blockade versus which patients can receive PD-1 blockade alone and avoid the potential excess toxicity of the CTLA-4 blockade. There are a lot of interesting questions there that still need to be answered. And of course, individuals with Lynch syndrome are just a fraction of those individuals who have MSI-high cancer. So there's also the question about whether non-Lynch syndrome associated MSI-high cancer responds differently to immunotherapy than Lynch syndrome associated MSI-high cancer. A lot of very interesting questions in the field for sure. Dr. Rafeh Naqash: Absolutely. My second question is more about trying to understand the role of ctDNA, MRD monitoring in individuals with Lynch syndrome. If somebody has a germline, you know, Lynch syndrome MSI-high cancer, when you do a tumor-informed ctDNA assessment, what do you capture generally there? Because, and this question stems from a discussion I've had with somebody regarding EGFR lung cancer, since I treat individuals with lung cancer, and the concept generally is that even if the tissue showed EGFR, but for MRD monitoring, when you do a barcoded sequence of different tumor specific mutations, it's not actually the EGFR that they track in the blood when they do ctDNA assessment. But from a Lynch syndrome standpoint, if you have a germline, right, which is the first hit, and then you have the somatic in the tumor, which is the second hit, are you aware or have you tried to look into this where what is exactly being followed if one had to follow MRD in a Lynch syndrome MSI-high colorectal cancer? Dr. Asaf Maoz: I think a lot of the MRD assays are proprietary, and so we don't receive information about what the mutations that are being tracked are. In general, the idea is to track mutations that we would not expect to disappear as part of resistant mechanisms. We want these to be truncal mutations. We want these to be mutations in which resistance is not expected to result in reversion mutations. But what specifically is being tracked is something that I don't know because these assays, the tumor-informed ones, are proprietary, and we don't get the results regarding specific mutations. When it's circulating tumor DNA that is not necessarily tumor-informed, we do get those results, but that is less so about the specific selection of mutations. Dr. Rafeh Naqash: Thank you for clarifying that question to some extent, of course, as you said, we don't know a lot, and we don't know what we don't know. That's the most important thing that I've learned in the process of understanding precision medicine and genomics, and it's a very fast-paced evolving field. Last question related to your project, what is the next step? Are you planning any next steps as a bigger multicenter study or validation of some sort? Dr. Asaf Maoz: There are two big questions that this study raises. One, is this true across multiple other sites, right? Because this is a single center study, and we really need additional centers to look at their data and validate whether they are also seeing that a substantial portion of deaths in individuals with Lynch syndrome are attributable to mismatch repair proficient cancer. The other question is whether we can look at specifically MSI-high cancer versus MS-stable cancer and understand what the mortality rate for each of those are. From a clinical perspective, it's important to counsel individuals with Lynch syndrome about general cancer screening outside of mismatch repair deficient tumors and to understand that there is also a risk of mismatch repair proficient tumors and that treatment for those tumors would be different. There's a lot of work to be done in the future. Another major area of need is to see whether tumors that are microsatellite stable can be sensitized to immunotherapy, and that is beyond the Lynch syndrome field, but that is something that certainly would benefit these individuals with Lynch syndrome who develop mismatch repair proficient cancer. Dr. Rafeh Naqash: That's very interesting to hear, and we'll look forward to seeing some of those developments shape in the next few years. Now, I'd like to spend a minute, minute and a half on you specifically as a researcher, clinician, scientist. Could you briefly highlight - because I remember meeting you several years back as a trainee, with your interest in genomics, computational research - could you briefly tell us what led you to hereditary cancer syndromes based on your research and work? What are some of the things that you learned along the way that other early career investigators can perhaps take lessons from? Dr. Asaf Maoz: Big questions there, thanks for asking. I got interested in the field of hereditary cancer syndromes when I came to the United States and started doing lab research in Stephen Gruber's lab at the time at USC. He's now at City of Hope. And my interest was originally looking at immunotherapy and immunology, but I went to the case conferences where we were learning about individuals with hereditary cancer, and those were kind of earlier days where we were still trying to figure out how to test and what the implications for these individuals would be. And through fellowship, I was also very interested in that, and I did my senior fellowship years with Dr. Yurgelun here at Dana-Farber, who is the director of the Lynch Syndrome Center. And I I think it's the combination between being able to treat individuals based on precision medicine and what the germline mutation is, but also the ability to prevent cancer and to develop strategies to intercept cancer early that is really appealing to me in this field. It's also a great field to be in because it's a small field. If you come to the CGA-IGC meeting, you'll be able to interact with everyone. Everyone is super collaborative, super nice, and I really recommend it to trainees. The CGA-IGC annual meeting is really a great opportunity to learn more and experience some of the advancement specifically in the GI hereditary space. Lessons for trainees. I think there are a lot of lessons that I could think about, but I think finding strong and supportive mentors is one of the things that has helped me most. I think that just having close relationship with your mentor, having frequent discussions and honest discussions about what is feasible, what is going to make a difference for your patients and your research and what you want to focus on is really important. And so I think if I had to choose one thing, I would say choose a mentor that you trust, that you feel you have a good relationship with, and that has the availability to support you. Dr. Rafeh Naqash: Thank you so much for those insightful comments, and thank you for sharing with us your journey, your project, and some of your interesting thoughts on this concept of hereditary cancers. Hopefully, we'll see more of this work being published in JCOPO through your lab or work from others. Dr. Asaf Maoz: Thank you so much. I appreciate the opportunity to be here. Dr. Rafeh Naqash: Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at ASCO.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, as he dives into today's top stories shaping America and the world. In this episode of The Wright Report, we cover an alarming report on Chinese illegal immigrants working as truck drivers inside the U.S., Beijing's growing cyber warfare networks, Trump's possible use of the Insurrection Act, and global political upheavals from France to Japan, with a surprising touch of good news about whales. From container trucks to coups and conservation, today's brief connects threats on American soil to global movements shaping our future. Chinese Illegal Truckers on U.S. Roads: A new investigation by the Daily Caller reveals that illegal immigrants from China are now driving trucks across America with commercial licenses obtained through a nonprofit tied to Beijing's United Front Work Department. The organization, CATOU, boasts a 100 percent pass rate for drivers who often cannot read English or road signs. Bryan warns that this, combined with China's control of port cranes and containerized missile systems, creates “an existential threat sitting in plain sight.” China's SIM Farm Cyber Operation: Law enforcement uncovered 300,000 Chinese-controlled SIM cards in New York capable of sending 30 million texts per minute, enough to crash city networks and emergency systems. The devices were linked to China's intelligence agency, the MSS, which has used similar systems to target U.S. officials and conservative figures. “No more scalpels. Chainsaws only,” Bryan urges, calling for mass visa revocations and deportations. Trump's Insurrection Act Warning: President Trump hinted he may invoke the 1807 Insurrection Act to deploy federal troops in cities like Portland and Chicago, where Democrat officials refuse to protect federal officers. The move recalls Lincoln's 1861 use of the law to quell rebellion. “These are acts of insurrection,” Bryan says, citing violence against ICE agents and the left's normalization of lawlessness. Global Political Upheaval: France's fifth prime minister in two years resigned after another budget collapse, while populists swept elections in the Czech Republic and Japan shifted right under new conservative leader Sanae Takaichi. Meanwhile, Michael Bloomberg announced a $50 million campaign to “fight populism” by grooming leftist city leaders worldwide. A Moment of Reflection and Hope: On the anniversary of Hamas's October 7 attacks, Bryan offered prayers for Israeli and Palestinian victims alike, urging peace as Trump's team nears a possible Gaza deal. In Argentina, scientists shared rare good news: the southern right whale population has rebounded to 4,700 and continues to grow. “We celebrate the whales,” Bryan concludes, “and feel bad for the humans who may go extinct if we're not careful.” "And you shall know the truth, and the truth shall make you free." - John 8:32 Keywords: Chinese illegal immigrants truck drivers, CATOU United Front Work Department, China port cranes container missile system, Daily Caller Chinese CDL investigation, SIM Farm cyber operation MSS New York, Trump Insurrection Act 1807 Portland Chicago, ICE agent attacks sanctuary cities, France government collapse Macron, Czech Republic populist Andrej Babiš, Japan Sanae Takaichi conservative leader, Michael Bloomberg anti-populism funding, Hamas October 7 anniversary Gaza peace deal, Argentina southern right whales population recovery
Microsoft tags a critical vulnerability in Fortra's GoAnywhere software. A critical Redis vulnerability could allow remote code execution. Researchers tie BIETA to China's MSS technology enablement. Competing narratives cloud the Oracle E-Business Suite breach. An Ohio-based vision care firm will pay $5 million to settle phishing-related data breach claims. “Trinity of Chaos” claims to be a new ransomware collective. LinkedIn files a lawsuit against an alleged data scraper. This year's Nobel Prize in Physics recognizes pioneering research into quantum mechanical tunneling. On today's Industry Voices segment, we are joined by Alastair Paterson from Harmonic Security, discussing shadow AI and the new era of work. Australia's AI-authored report gets a human rewrite. Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest On today's Industry Voices segment, we are joined by Alastair Paterson, CEO and Co-Founder of Harmonic Security, discussing shadow AI and the new era of work. You can hear the full conversation with Alastair here. Selected Reading Microsoft: Critical GoAnywhere Bug Exploited in Medusa Ransomware Camp (Infosecurity Magazine) Redis warns of critical flaw impacting thousaRends of instances (Bleeping Computer) BIETA: A Technology Enablement Front for China's MSS (Recorded Future) Well, Well, Well. It's Another Day. (Oracle E-Business Suite Pre-Auth RCE Chain - CVE-2025-61882) (Labs) EyeMed Agrees to Pay $5M to Settle Email Breach Litigation (Govinfo Security) Ransomware Group “Trinity of Chaos” Launches Data Leak Site (Infosecurity Magazine) LinkedIn sues ProAPIs for using 1M fake accounts to scrape user data (Bleeping Computer) The Nobel Prize for physics is awarded for discoveries in quantum mechanical tunneling (NPR) Deloitte refunds Australian government over AI in report (The Register) Share your feedback. What do you think about CyberWire Daily? Please take a few minutes to share your thoughts with us by completing our brief listener survey. Thank you for helping us continue to improve our show. Want to hear your company in the show? N2K CyberWire helps you reach the industry's most influential leaders and operators, while building visibility, authority, and connectivity across the cybersecurity community. Learn more at sponsor.thecyberwire.com. The CyberWire Daily podcast is a production of N2K Networks, your source for critical industry insights, strategic intelligence, and performance-driven learning products. © N2K Networks, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices
Look no further folks, MSS' resident ghost cat expert is here. Our fan favorite this week is Annie! Check out her store at stashworthyfabric.com or on facebook and instagram at Stash Worthy Fabric. Please remember to Rate, Review, and Subscribe on Apple Podcast and Spotify. If you would like to write in, find us on Patreon, buy MERCH, or find our social handles, go to our website, www.myskepticalsister.com You can also support us with a one time donation at https://www.buymeacoffee.com/myskepticaz
En ESTO NO TIENE NOMBRE, analizamos el éxito diplomático del presidente Luis Abinader tras la aprobación en la ONU de la Fuerza de Supresión de Pandillas para Haití. Abinader celebró la conversión de la Misión MSS en una fuerza de 5,500 efectivos. Entérate cómo la diplomacia dominicana lideró este esfuerzo clave para la seguridad regional y la estabilidad en el país vecino.
By pressuring broadcast giant ABC to suspend Jimmy Kimmel's late-night show—a decision that ABC reversed this week—the Trump administration has taken its assault on the First Amendment to new heights over the past week. Kimmel's show is back on the air for now, but the whole debacle has revealed just how vulnerable free speech in America is to political and corporate authoritarianism. This is a crisis, and both Democrats and Republicans have set the stage for it. “As corporate media accelerate their censorship of comedians and journalists,” renowned media analyst Jeff Cohen writes, “we must realize that we got to this dire situation because of old-fashioned, bipartisan corruption in Washington, DC.” In this episode of The Marc Steiner Show, Marc speaks with Cohen about how the consolidation of corporate control over the media, mixed with a ravenously censorious Trump administration, has left free speech in America hanging by a thread.Guest:Jeff Cohen is a retired journalism professor at Ithaca College and the author of Cable News Confidential: My Misadventures in Corporate Media. In 1986, Cohen founded the media watch group FAIR; he is also the co-founder of RootsAction.org.Additional resources:Jeff Cohen, Salon, “Kimmel's suspension shows media censorship is a structural problem”Bobby Allyn, NPR, “Legal experts say pulling Jimmy Kimmel from air may amount to illegal ‘jawboning'”Paul Starr, The American Prospect, “Capture the media, control the culture?”Credits:Producer: Rosette SewaliStudio Production: David HebdenAudio Post-Production: Stephen FrankFollow The Marc Steiner Show on Spotify Follow The Marc Steiner Show on Apple PodcastsHelp us continue producing The Marc Steiner Show by following us and becoming a monthly sustainer.Sign up for our newsletterFollow us on:Bluesky: @therealnews.comFacebook: The Real News NetworkTwitter: @TheRealNewsYouTube: @therealnewsInstagram: @therealnewsnetwork
By pressuring broadcast giant ABC to suspend Jimmy Kimmel's late-night show—a decision that ABC reversed this week—the Trump administration has taken its assault on the First Amendment to new heights over the past week. Kimmel's show is back on the air for now, but the whole debacle has revealed just how vulnerable free speech in America is to political and corporate authoritarianism. This is a crisis, and both Democrats and Republicans have set the stage for it. “As corporate media accelerate their censorship of comedians and journalists,” renowned media analyst Jeff Cohen writes, “we must realize that we got to this dire situation because of old-fashioned, bipartisan corruption in Washington, DC.” In this episode of The Marc Steiner Show, Marc speaks with Cohen about how the consolidation of corporate control over the media, mixed with a ravenously censorious Trump administration, has left free speech in America hanging by a thread.Guest:Jeff Cohen is a retired journalism professor at Ithaca College and the author of Cable News Confidential: My Misadventures in Corporate Media. In 1986, Cohen founded the media watch group FAIR; he is also the co-founder of RootsAction.org.Additional resources:Jeff Cohen, Salon, “Kimmel's suspension shows media censorship is a structural problem”Bobby Allyn, NPR, “Legal experts say pulling Jimmy Kimmel from air may amount to illegal ‘jawboning'”Paul Starr, The American Prospect, “Capture the media, control the culture?”Credits:Producer: Rosette SewaliStudio Production: David HebdenAudio Post-Production: Stephen FrankFollow The Marc Steiner Show on Spotify Follow The Marc Steiner Show on Apple PodcastsHelp us continue producing The Marc Steiner Show by following us and becoming a monthly sustainer.Sign up for our newsletterFollow us on:Bluesky: @therealnews.comFacebook: The Real News NetworkTwitter: @TheRealNewsYouTube: @therealnewsInstagram: @therealnewsnetwork
This week we talk about cyberespionage, China, and asymmetrical leverage.We also discuss political firings, hardware infiltration, and Five Eyes.Recommended Book: The Fourth Turning Is Here by Neil HoweTranscriptIn the year 2000, then-General Secretary of the Chinese Communist Party, Jiang Zemin (jong ZEM-in), approved a plan to develop so-called “cyber coercive capabilities”—the infrastructure for offensive hacking—partly as a consequence of aggressive actions by the US, which among other things had recently bombed the Chinese embassy in Belgrade as part of the NATO campaign in Yugoslavia.The US was a nuclear power with immense military capabilities that far outshone those of China, and the idea was that the Chinese government needed some kind of asymmetrical means of achieving leverage against the US and its allies to counter that. Personal tech and the internet were still relatively young in 2000—the first iPhone wouldn't be released for another seven years, for context—but there was enough going on in the cyber-intelligence world that it seemed like a good point of leverage to aim for.The early 2000s Chairman of the CCP, Hu Jintao, backed this ambition, citing the burgeoning threat of instability-inducing online variables, like those that sparked the color revolutions across Europe and Asia, and attack strategies similar to Israel's Stuxnet cyberattack on Iran as justification, though China's growing economic dependence on its technological know-how was also part of the equation; it could evolve its capacity in this space relatively quickly, and it had valuable stuff that was targetable by foreign cyberattacks, so it was probably a good idea to increase their defenses, while also increasing their ability to hit foreign targets in this way—that was the logic here.The next CCP Chairman, Xi Jinping, doubled-down on this effort, saying that in the cyber world, everyone else was using air strikes and China was still using swords and spears, so they needed to up their game substantially and rapidly.That ambition seems to have been realized: though China is still reportedly regularly infiltrated by foreign entities like the US's CIA, China's cybersecurity firms and state-affiliated hacker groups have become serious players on the international stage, pulling off incredibly complex hacks of foreign governments and infrastructure, including a campaign called Volt Typhoon, which seems to have started sometime in or before 2021, but which wasn't discovered by US entities until 2024. This campaign saw Chinese hackers infiltrating all sorts of US agencies and infrastructure, initially using malware, and then entwining themselves with the operating systems used by their targets, quietly syphoning off data, credentials, and other useful bits of information, slowly but surely becoming even more interwoven with the fabric of these systems, and doing so stealthily in order to remain undetected for years.This effort allowed hackers to glean information about the US's defenses in the continental US and in Guam, while also helping them breach public infrastructure, like Singapore's telecommunications company, Singtel. It's been suggested that, as with many Chinese cyberattacks, this incursion was a long-game play, meant to give the Chinese government the option of both using private data about private US citizens, soldiers, and people in government for manipulation or blackmail purposes, or to shut down important infrastructure, like communications channels or electrical grids, in the event of a future military conflict.What I'd like to talk about today is another, even bigger and reportedly more successful long-term hack by the Chinese government, and one that might be even more disruptive, should there ever be a military conflict between China and one of the impacted governments, or their allies.—Salt Typhoon is the name that's been given to a so-called '“advanced persistent threat actor,” which is a formal way of saying hacker or hacker group, by Microsoft, which plays a big role in the cybersecurity world, especially at this scale, a scale involving not just independent hackers, but government-level cyberespionage groups.This group is generally understood to be run out of the Chinese Ministry of State Security, or MSS, and though it's not usually possible to say something like that for certain, hence the “generally understood” component of that statement, often everyone kind of knows who's doing what, but it's imprudent to say so with 100% certainty, as cyberespionage, like many other sorts of spy stuff, is meant to be a gray area where governments can knock each other around without leading to a shooting war. If anyone were to say with absolute certainty, yes, China is hacking us, and it's definitely the government, and they're doing a really good job of it, stealing all our stuff and putting us at risk, that would either require the targeted government to launch some sort of counterstrike against China, or would leave that targeted government looking weak, and thus prone to more such incursions and attacks, alongside any loss of face they might suffer.So there's a lot of hand-waving and alluding in this sphere of diplomacy and security, but it's basically understood that Salt Typhoon is run by China, and it's thought that they've been operating since at least 2020.Their prime function seems to be stealing as much classified data as they can from governments around the world, and scooping up all sorts of intellectual property from corporations, too.China's notorious for collecting this kind of IP and then giving it to Chinese companies, which have become really good at using such IP, copying it, making it cheaper, and sometimes improving upon it in other ways, as well. This government-corporation collaboration model is fundamental to the operation of China's economy, and the dynamic between its government, it's military, its intelligence services, and its companies, all of which work together in various ways.It's estimated that Salt Typhoon has infiltrated more than 200 targets in more than 80 countries, and alongside corporate entities like AT&T and Verizon, they also managed to scoop up private text messages from Kamala Harris' and Donald Trump's presidential campaigns in 2024, using hacks against phone services to do so.Three main Chinese tech companies allegedly helped Salt Typhoon infiltrate foreign telecommunications companies and internet service providers, alongside hotel, transportation, and other sorts of entities, which allowed them to not just grab text messages, but also track people, keeping tabs on their movements, which again, might be helpful in future blackmail or even assassination operations.Those three companies seem to be real-deal, actual companies, not just fronts for Chinese intelligence, but the government was able to use them, and the services and products they provide, to sneak malicious code into all kinds of vital infrastructure and all sorts of foreign corporations and agencies—which seems to support concerns from several years ago about dealing with Chinese tech companies like Huawei; some governments decided not to work with them, especially in building-out their 5G communications infrastructure, due to the possibility that the Chinese government might use these ostensibly private companies as a means of getting espionage software or devices into these communications channels or energy grids. The low prices Huawei offered just wasn't worth the risk.The US government announced back in 2024 that Salt Typhoon had infiltrated a bunch of US telecommunications companies and broadband networks, and that routers manufactured by Cisco were also compromised by this group. The group was also able to get into ISP services that US law enforcement and intelligence services use to conduct court-authorized wiretaps; so they weren't just spying on individuals, they were also spying on other government's spies and those they were spying on.Despite all these pretty alarming findings, in the midst of the investigation into these hacks, the second US Trump administration fired the government's Cyber Safety Review Board, which was thus unable to complete its investigation into Salt Typhoon's intrusion.The FBI has since issued a large bounty for information about those involved in Salt Typhoon, but that only addresses the issue indirectly, and there's still a lot we don't know about this group, the extent of their hacking, and where else they might still be embedded, in part because the administration fired those looking into it, reportedly because the administration didn't like this group also looking into Moscow's alleged interference in the 2016 presidential election, and Salt Typhoon's potential interference with the 2024 presidential election, both of which Trump won.The US government has denied these firings are in any way political, saying they intend to focus on cyber offense rather than defense, and pointing out that the current approach to investigating these sorts of things was imperfect; which is something that most outside organizations would agree on.That said, there are concerns that these firings, and other actions against the US's cyberthreat defensive capabilities, are revenge moves against people and groups that have said the 2020 presidential election, which Trump lost to Joe Biden, was the most secure and best-run election in US history; which flies in the face of Trump's preferred narrative that he won in 2020—something he's fond of repeating, though without evidence, and with a vast body of evidence against his claim.The US has also begun pulling away from long-time allies that it has previously collaborated with in the cyberespionage and cyberdefense sphere, including its Five Eyes partners, the UK, Canada, Australia, and New Zealand.Since Tulsi Gabbard was installed as the Director of National Intelligence by Trump's new administration, US intelligence services have been instructed to withhold information about negotiations with Russia and Ukraine from these allies; something that's worrying intelligence experts, partly because this move seems to mostly favor Russia, and partly because it represents one more wall, of many, that the administration seems to be erecting between the US and these allies. Gabbard herself is also said to be incredibly pro-Russian, so while that may not be influencing this decision, it's easy to understand why many allies and analysts are concerned that her loyalties might be divided in this matter.So what we have is a situation in which political considerations and concerns, alongside divided priorities and loyalties within several governments, but the US in particular right now, might be changing the layout of, and perhaps even weakening, cybersecurity and cyberespionage services at the very moment these services might be most necessary, because a foreign government has managed to install itself in all kinds of agencies, infrastructure, and corporations.That presence could allow China to milk these entities for information and stolen intellectual property, but it could also put the Chinese government in a very favorable position, should some kind of conflict break out, including but not limited to an invasion of Taiwan; if the US's electrical grids or telecommunications services go down, or the country's military is unable to coordinate with itself, or with its allies in the Pacific, at the moment China invades, there's a non-zero chance that would impact the success of that invasion in China's favor.Again, this is a pretty shadowy playing field even at the best of times, but right now there seems to be a lot happening in the cyberespionage space, and many of the foundations that were in place until just recently, are also being shaken, shattered, or replaced, which makes this an even more tumultuous, uncertain moment, with heightened risks for everybody, though maybe the opposite for those attacking these now more-vulnerable bits of infrastructure and vital entities.Show Noteshttps://www.nbcnews.com/tech/security/china-used-three-private-companies-hack-global-telecoms-us-says-rcna227543https://media.defense.gov/2025/Aug/22/2003786665/-1/-1/0/CSA_COUNTERING_CHINA_STATE_ACTORS_COMPROMISE_OF_NETWORKS.PDFhttps://www.nytimes.com/2025/04/05/us/politics/trump-loomer-haugh-cyberattacks-elections.htmlhttps://www.france24.com/en/americas/20250826-has-the-us-shut-its-five-eyes-allies-out-of-intelligence-on-ukraine-russia-peace-talkshttps://www.axios.com/2025/09/04/china-salt-typhoon-fbi-advisory-us-datahttps://www.wsj.com/politics/national-security/chinese-spies-hit-more-than-80-countries-in-salt-typhoon-breach-fbi-reveals-59b2108fhttp://axios.com/2025/08/02/china-usa-cyberattacks-microsoft-sharepointhttps://www.axios.com/2024/12/03/salt-typhoon-china-phone-hackshttps://www.nytimes.com/2025/09/04/world/asia/china-hack-salt-typhoon.htmlhttps://www.euronews.com/2025/09/04/trump-and-jd-vance-among-targets-of-major-chinese-cyberattack-investigators-sayhttps://www.congress.gov/crs-product/IF12798https://www.fcc.gov/document/implications-salt-typhoon-attack-and-fcc-responsehttps://en.wikipedia.org/wiki/Salt_Typhoonhttps://en.wikipedia.org/wiki/2024_global_telecommunications_hackhttps://en.wikipedia.org/wiki/Chinese_interference_in_the_2024_United_States_electionshttps://www.theregister.com/2025/08/28/how_does_china_keep_stealing/https://www.nsa.gov/Press-Room/Press-Releases-Statements/Press-Release-View/Article/4287371/nsa-and-others-provide-guidance-to-counter-china-state-sponsored-actors-targeti/https://chooser.crossref.org/?doi=10.2307%2Fjj.16040335https://en.wikipedia.org/wiki/Cyberwarfare_and_Chinahttps://en.wikipedia.org/wiki/Volt_Typhoon This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe
Episode 348. Black Americans make up just 13% of the U.S. population, yet their influence shapes the entire world. From music and dance to fashion, language, and beyond, Black American culture sets the global standard. In this episode, we dive into how a community so often marginalized has become the heartbeat of worldwide culture. Sponsor: The LRPod Network Free Community. Podcast videos, exclusive content and more. Podcast Website ----------------- Quick Links ========== Personal Finance, MSS is a groundbreaking video series that dives into the core principles of economics, wealth distribution, and financial stability. It's perfect for learners, professionals, and anyone looking to understand the forces shaping the global economy. As an affiliate, you're helping to spread knowledge and empower others with valuable insights. How To Make An Additional $1,000 - $3,000 Per Day In Passive Income On Complete Autopilot In 2025... Discover NITRIC BOOST ULTRA The 100% Natural Remedy for Hard & Long-Lasting Erections
Born Along Die Along. Welcome to Friday Night Motivation - your weekly dose of inspiration to ignite your drive and propel you toward your goals with a back drop of music. Let's dive in! Sponsor: Why You Need A Podcast, eBook and Video Guide ✨ Unlock Success with The Weallth Circle – Free on Patreon! Get early-access podcast videos, behind-the-scenes drops, exclusive content, and more. Join the movement, build your mindset, and level up your hustle today!
Three Buddy Problem - Episode 56: China-focused researcher Dakota Cary joins the buddies to dig into China's sprawling cyber ecosystem, from the HAFNIUM indictments and MSS tasking pipelines to the murky world of APT contractors and the ransomware hustle. We break down China's “entrepreneurial” model of intelligence collection, why public visibility into these threat actors is so hard to get right, and how companies like Microsoft get caught in the geopolitical crossfire. Plus: a deep dive on suspected MAPP leaks and Sharepoint zero-days, Singapore targeted by extremely sophisticated China-nexus hacking group, soft censorship in corporate threat-intel, and whether the U.S. should rethink how it fills its intelligence gaps. Cast: Dakota Cary (https://www.linkedin.com/in/dakotacary/), Juan Andres Guerrero-Saade (https://twitter.com/juanandres_gs), Ryan Naraine (https://twitter.com/ryanaraine) and Costin Raiu (https://twitter.com/craiu).
As the Trump administration ramps up its violent immigration raids around the country, increasingly targeting immigrants with no criminal record, and racially profiling Latinos to meet arrest quotas, immigrant communities in Baltimore and beyond are living in terror. In this urgent episode of The Marc Steiner Show, Marc speaks with two immigrant justice organizers in Baltimore—whose identities are being protected to ensure their safety—about the horrifying reality that immigrant families, particularly Latino families, are experiencing right now. “If you don't look Latino, do you tell your child to carry around their passport or their birth certificate?... US citizens are being detained only because they look Latino, because they are Latino.”Additional resources:Maanvi Singh, Will Craft, & Andrew Witherspoon, The Guardian, “How Trump has supercharged the immigration crackdown - in data”Jaisal Noor, Baltimore Beat, “Baltimore residents are mobilizing to protect their immigrant neighbors from ICE”Tara Lynch, CBS Baltimore, “Community demands release of Maryland pastor who was arrested by ICE”Credits:Producer: Rosette SewaliStudio Production: David HebdenAudio Post-Production: Stephen FrankFollow The Marc Steiner Show on Spotify Follow The Marc Steiner Show on Apple PodcastsHelp us continue producing The Marc Steiner Show by following us and becoming a monthly sustainer.Sign up for our newsletterFollow us on:Bluesky: @therealnews.comFacebook: The Real News NetworkTwitter: @TheRealNewsYouTube: @therealnewsInstagram: @therealnewsnetwork
Episode 339. What if 'Oumuamua was a probe sent to detect life on Earth, and now 3I/Atlas is the incoming reconnaissance fleet? It's a chilling thought, one that makes you hope it's just a comet. But what if it's not? What if first contact already happened-and this is phase two? Enjoy the show! Sponsor:Why You Need a Podcast, Ebook w/ Video Guide Podcast Website Quick Links ========== Earn $10K+/Month with This 3-Step Blueprint — No Investment, Just 30 Minutes a Day! How To Make An Additional $1,000 - $3,000 Per Day In Passive Income On Complete Autopilot In 2025... Personal Finance, MSS is a groundbreaking video series that dives into the core principles of economics, wealth distribution, and financial stability. It's perfect for learners, professionals, and anyone looking to understand the forces shaping the global economy.
As the Trump administration ramps up its violent immigration raids around the country, increasingly targeting immigrants with no criminal record, and racially profiling Latinos to meet arrest quotas, immigrant communities in Baltimore and beyond are living in terror. In this urgent episode of The Marc Steiner Show, Marc speaks with two immigrant justice organizers in Baltimore—whose identities are being protected to ensure their safety—about the horrifying reality that immigrant families, particularly Latino families, are experiencing right now. “If you don't look Latino, do you tell your child to carry around their passport or their birth certificate?... US citizens are being detained only because they look Latino, because they are Latino.”Additional resources:Maanvi Singh, Will Craft, & Andrew Witherspoon, The Guardian, “How Trump has supercharged the immigration crackdown - in data”Jaisal Noor, Baltimore Beat, “Baltimore residents are mobilizing to protect their immigrant neighbors from ICE”Tara Lynch, CBS Baltimore, “Community demands release of Maryland pastor who was arrested by ICE”Credits:Producer: Rosette SewaliStudio Production: David HebdenAudio Post-Production: Stephen FrankFollow The Marc Steiner Show on Spotify Follow The Marc Steiner Show on Apple PodcastsHelp us continue producing The Marc Steiner Show by following us and becoming a monthly sustainer.Sign up for our newsletterFollow us on:Bluesky: @therealnews.comFacebook: The Real News NetworkTwitter: @TheRealNewsYouTube: @therealnewsInstagram: @therealnewsnetwork
What Are You Drinking? Banter 108 Bachelorette Smash or Pass White Sox Talk Andrew Vaughn Trade Brooks Baldwin and Tim Elko Luis Robert Jr Will Venable Thank Yous and GFYs
On this week's show Patrick Gray and Adam Boileau discuss the week's cybersecurity news: Cyber firms agree to deconflict and cross-reference hacker group names Russian nuclear facility blueprints gathered from public procurement websites Someone audio deepfaked the White House Chief of Staff, but for the dumbest reasons Germany identifies the Trickbot kingpin Google spots China's MSS using Calendar events for malware C2 Meta apps abuse localhost listeners to track web sessions. This week's episode is sponsored by automation vendor Tines. Its Field CISO, Matt Muller, joins the show to discuss an open letter penned by JP Morgan Chase's CISO that pleads with Software as a Service suppliers to try to suck less at security. This episode is also available on Youtube. Show notes 'Forest Blizzard' vs 'Fancy Bear' - cyber companies hope to untangle weird hacker nicknames | Reuters Ukraine's Massive Drone Attack Was Powered by Open Source Software Massive security breach: Russian nuclear facilities exposed online How a Spyware App Compromised Assad's Army - New Lines Magazine Exclusive | Federal Authorities Probe Effort to Impersonate White House Chief of Staff Susie Wiles - WSJ Malaysian home minister's WhatsApp hacked, used to scam contacts | The Record from Recorded Future News U.S. Sanctions Cloud Provider ‘Funnull' as Top Source of ‘Pig Butchering' Scams – Krebs on Security Top counter antivirus service disrupted in global takedown | CyberScoop Cops in Germany Claim They've ID'd the Mysterious Trickbot Ransomware Kingpin | WIRED Australian ransomware victims now must tell the government if they pay up | The Record from Recorded Future News Google: China-backed hackers hiding malware in calendar events | Cybersecurity Dive Coinbase breach linked to customer data leak in India, sources say | Reuters US military IT specialist arrested for allegedly trying to leak secrets to foreign government | The Record from Recorded Future News NSO appeals WhatsApp decision, says it can't pay $168 million in ‘unlawful' damages | The Record from Recorded Future News ConnectWise says nation-state attack targeted multiple ScreenConnect customers | The Record from Recorded Future News Google Online Security Blog: Sustaining Digital Certificate Security - Upcoming Changes to the Chrome Root Store Meta and Yandex are de-anonymizing Android users' web browsing identifiers - Ars Technica An Open Letter to Third-Party Suppliers
© 2020-2026 Ivy Podcast Discovery LLC
