Podcast appearances and mentions of Anna Burke

Send us a textAnna Burke joins me to chat about book 3 in the Seal Cove series, Windlass, available July 8th, what's next in the Compass Rose series, the anthology, By Her Sword, Bywater Books, living in Massachusetts and more!Support the show

What does the new political landscape mean for people with disability and the future of the NDIS? In this special live episode of Reasonable & Necessary, Dr George Taleporos is joined by an incredible panel of disability leaders – El Gibbs, Trinity Ford, and Anna Burke – to unpack what the election result means for the disability community.

Why are tens of thousands of Australians with disability still being placed in group homes under the NDIS and what can be done about it? In this episode, Dr George Taleporos is joined by Jess Walker and Anna Burke from the Summer Foundation to unpack their new report, Moving Out, Moving On, which calls for urgent reform of housing and living supports under the NDIS. We explore the hidden cost of group homes, the benefits of Individualised Living Arrangements (ILAs), and hear from Bar and Matt, two people who are living proof that a better way is possible.

For several years now, we've heard teachers talk about being overworked and stressed out. They say they come encounter or see harassment - and even violence in the classroom. Teachers also worry about how to include students who have disabilities and mental health issues. In the big picture, they say, things have to change. The provincial government's appointed education accord team is working on it. Anne Burke, co-chair of the team, spoke with the CBC's Leigh Anne Power.

Send us a textIn this holiday podcast episode, Tagan Shephard, Stephanie Shea, Rey Spangler, Rita Potter, Rachel Lacey, Anna Burke, Quinn Riley, Krystina Rivers, Kris Bryant, TB Markinson and Miranda Macleod, Jen Lyon, J.E. Leak, Erica Lee, Jamey Moody, Clare Ashton, Chris Zett, Cari Hunter and A.L. Brooks share with us their holiday plans, favorite holiday drinks and songs and the best thing to happen to them in 2024. Support the show

This is one of my favourite shows and Mila is one of my favourite authors. Topics covered in the show:Mila's latest book, ReverenceBeing authentically youHow Milena McKay came to beHow purpose and meaning plays a huge role in storytellingHow to build an author brand and the importance of writing the stories you want to writeLINKS TO MILENA McKAYWebsiteMilena McKay Patreon AccountReverence New Book ReleaseOther Authors referred to in the show: Lee Winter, Roslyn Sinclair, Clare Ashton, Anna Burke, Virginia Black, Ann McCann and Kris Bryant LINKSConnect with Natalie at Instagram, Facebook or LinkedInDo you like journalling and are your wanting to create new habits? Your Morning Ritual is waiting and ready for you.Need some motivation on your Mondays - here's Natalie's Monday Quick Wins email.

Samara Breger joins me to chat about her enthralling book, A Long Time Dead, the brilliant cover designed by Ann McMan, vampires, what she loves about her publisher, Bywater Books, how she met her wife, her career as a journalist, Anna Burke and much more! Purchase Samara's books at Bywater Books: You searched for samara breger - Bywater BooksTo support this podcast, you can buy me a coffee: sapphiclaura is Bringing you fun chats with the best authors in sapphic fiction. (buymeacoffee.com)Support the Show.Support the Show.

Are all cats ice queens? Are all ice queens cats? What if they're British? Kris's Alexa wants to weigh in on this very important conversation, too.  We answer a listener question about debut authors that swept us off our feet, making this a recommendation-heavy episode. After this edifying topic, Kris and Tara belly up to a long conversation about the latest season of the trash can that is the latest season of Love is Blind. Official Recommendations From Kris: Nurses (Global/NBC) This week, Kris recommends the Canadian medical drama Nurses (Global/NBC), which follows a group of nurses in a busy downtown Toronto hospital. There's a lot of death and dying in the show, so watch out for that if you're squeamish. Otherwise, Kris describes it as a much less angsty Grey's Anatomy. From Tara: Tempting Olivia by Clare Ashton Tara recommends the contemporary sapphic romance Tempting Olivia by Clare Ashton. An icy, perfectionist lawyer with a secret celebrity crush ends up representing that celebrity during her divorce and, well, you can kind of figure out the rest from there. Tara praises the reality of how the relationship is handled, including how the power dynamics of their professional/client relationship are handled. Tara adored this book so much so that it's now her favourite Clare Ashton book, toppling the reigning champ, Poppy Jenkins. Run, don't walk. Works/People Discussed Vengeance Planning for Amateurs by Lee Winter The Delicate Things We Make by Milena McKay Compass Rose by Anna Burke Stick McLaughlin: The Prohibition Years by C.F. Frizzell Changing Majors by Ana Hartnett The Red Files by Lee Winter Jericho by Ann McMan The Music and the Mirror by Lola Keeley Avatar: The Last Airbender (Netflix) Survivor, Season 46 (CBS) The Walking Dead: The Ones Who Live (AMC) Love is Blind, Season 6 (Netflix) RuPaul's Drag Race, Season 16 (MTV) RuPaul's Drag Race: UK vs. the World, Season 3 (BBC Three) Taylor Tomlinson: Have it All (Netflix) Lean in to Love by Catherine Lane Support & follow the show Buy us a Ko-fi Sign up for our newsletter on Substack Twitter: @queerlyrec Facebook: @QueerlyRecommended Instagram: @queerlyrecommended Blusky: @queerlyrec.bsky.social Get all our links on Linktr.ee Support local animal shelters by joining Kris's Patreon

We've got a packed house this week at ol' QR HQ. Kris has some big projects out on them lonely roads. Tara's reading slump seems to have been busted (fingers crossed). We talk card conventions and we answer your questions. Pull up a chair and hang out for a while. Official Recommendations From Kris: Theater Camp (2023) This week, Kris recommends Theater Camp. It's a delightful and heartfelt mockumentary-style comedy about a summer theater camp in New York where the kids are wonderful and the adults are all hot messes. From Tara: How You Get the Girl by Anita Kelly This week, Tara recommends How You Get the Girl by Anita Kelly, a cozy and queer sports romance. Which sport? Tara doesn't know. Basketball, maybe?  It features characters from Kelly's other books but stands alone just fine. Tara adored this book. Works/People Discussed All Things Beautiful by Alaina Erdell The Grammys The Color Purple (2023) True Detective: Night Country (HBO) RuPaul's Drag Race, Season Sixteen (MTV) Not in the Plan by Dana Hawkins Keep This Off the Record by Arden Joy Much Ado About Nothing (1993) Thorn by Anna Burke The Bear (FX on Hulu) Love & Other Disasters by Anita Kelly Something Wild & Wonderful by Anita Kelly Support & follow the show Buy us a Ko-fi Sign up for our newsletter on Substack Twitter: @queerlyrec Facebook: @QueerlyRecommended Instagram: @queerlyrecommended Blusky: @queerlyrec.bsky.social Get all our links on Linktr.ee Support local animal shelters by joining Kris's Patreon

Bywater Books authors Anna Burke, Jenn Alexander and Virginia Black join me to chat about Soul Food Stories, released today, and their short stories from the book, their most recent releases, plans for Halloween, what they love about where they live and much more! Purchase the anthology here: Soul Food Stories - Bywater BooksTo support this podcast, you can buy me a coffee at sapphiclaura is Bringing you fun chats with the best authors in sapphic fiction. (buymeacoffee.com)Support the show

Anna Burke joins me to chat about her upcoming The Rose of Pieria, what's next in the Compass Rose and Seal Cove series, how she met her wife, what her role would be as a crew member of Man O War and more! To learn more about Anna and find links to purchase her books visit: Anna Burke – Author (wordpress.com)To support this podcast, you can join my Patreon, @ Sapphic Book Review | creating Bonus fun with sapphic authors | Patreonor buy me a coffee @ sapphiclaura is Bringing you fun chats with the best authors in sapphic fiction. (buymeacoffee.com)Support the show

BE LIKE HER LIVE On ACADEMY LIVE With Special Guest Anna Burke AO by Ralph Barba

This month on Episode 25 of Discover CircRes, host Cindy St. Hilaire highlights the topics covered in the June 11th Compendium on Peripheral Vascular Disease, as well as discussing two original research articles from the May 28th issue of Circulation Research. This episode also features an in-depth conversation with Drs Eric Small and Ryan Burke from the University of Rochester Medical Center about their study Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.   Article highlights:   Ghosh, et al. IAP Overexpression Attenuates Atherosclerosis   Dörr, et al. Etelcalcetide for Cardiac Hypertrophy   Compendium on Peripheral Vascular Disease   Cindy St. Hilaire:        Hi and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles presented in our May 28th and June 11th issues of Circ Res. I'm also going to speak with Drs Eric Small and Ryan Burke from the University of Rochester Medical Center about their study Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Cindy St. Hilaire:        The first article I want to share comes from the May 28th issue and is titled Over-Expression of Intestinal Alkaline Phosphatase Attenuates Atherosclerosis. The first author is Siddhartha Ghosh, and the corresponding author is Shobha Ghosh, and they're from VCU Medical Center. The Western diet is a colloquial term that is used to say a diet that is high in fats, sugars, refined grains, and red meat. A diet consisting of these foods can cause intestinal inflammation, which weakens the gut lining and facilitates transfer of the bacterial toxin lipopolysaccharide, or LPS. Once in the blood, LPS causes systemic inflammation. Cindy St. Hilaire:        Patients with diseases such as diabetes and atherosclerosis, in which inflammation is a major contributor, have increased levels of LPS in the blood. In the gut, the enzyme, intestinal alkaline phosphatase, or IAP, is a critical barrier for the intestine. It regulates the integrity of epithelial cell junctions and helps to detoxify LPS, both of which limit intestinal inflammation. Clinical trials of oral IAP have hinted at its potential to treat patients with ulcerative colitis. In this study, Dr Ghosh and colleagues investigated whether over-expression of IAP can reduce systemic LPS and help to prevent atherosclerosis. They fed atherosclerosis-prone mice engineered to over-express gut IAP, a Western diet for 16 weeks and found that the animals had improved gut integrity, reduced plasma levels of LPS, reduced gut lipid absorption, lower body weight, and decreased aortic plaque burden as compared to normal controls. Together, these results indicate that improving gut barrier integrity by boosting IAP, either by diet choices or pharmacologically, may help to slow atherosclerosis. Cindy St. Hilaire:        The second article I want to share is titled Randomized Trial of Etelcalcetide for Cardiac Hypertrophy and Hemodialysis. The first author is Katharina Dörr, and the corresponding author is Rainer Oberbauer, and they're from the Medical University of Vienna. In chronic kidney disease, or CKD, loss of renal function leads to systemic mineral imbalances. These imbalances trigger further physiological problems, such as the excess production of parathyroid hormone and growth factor, FGF23. The former can cause muscle and bone weakness, and the latter has been implicated in left ventricle hypertrophy. Hyperparathyroidism can be treated with calcimimetics or with vitamin D, but while both approaches lower parathyroid hormone levels, calcimimetics also lower FGF23. Cindy St. Hilaire:        This study investigated whether CKD patients treated with a calcimimetic, etelcalcitide, had any measurable improvements in left ventricle mass, as compared to patients given a vitamin D analog, alfacalcidol. In a single blind randomized study, 32 CKD patients were treated with etelcalcitide and 30 were treated with alfacalcidol for a year. At the end of the study, left ventricle mass measured by magnetic resonance imaging, was found to be significantly lower in the etelcalcitide group. FGF23 levels had also declined in this group, but had risen in the alfacalcidol group. The results indicate that calcimimetics reduce the risk of cardiac hypertrophy, as well as treating hyperthyroidism, and thus, might be a preferable treatment option in CKD. Cindy St. Hilaire:        The June 11th issue of Circulation Research is the Peripheral Vascular Disease Compendium, and in this compendium, we have 14 articles that are written by the leading experts who present an update on the state of the field of peripheral vascular disease research. They discuss current research and also current therapeutic options. Drs Nick Leeper and Naomi Hamburg serve as the guest editors of this compendium. Drs Derek Klarin, Phil Tsao, and Scott Damrauer discuss the genetic determinants of peripheral artery disease. Drs Kunihiro Matsushita and Aaron Aday present a Review on the epidemiology of peripheral artery disease and polyvascular disease. Cindy St. Hilaire:        The potential of leveraging machine learning and artificial intelligence to improve peripheral artery disease detection, treatment, and outcomes is covered by Drs Alyssa Flores, Falen Demsas, Nicholas Leeper, and Elsie Ross. The benefits of walking as exercise therapy and its benefits on lower extremity skeletal muscle is presented by Drs Mary McDermott, Sudarshan Dayanidhi, Kate Kosmac, Sunil Saini, Josh Slysz, Christiaan Leeuwenburgh, Lisa Hartnell, Robert Sufit, and Luigi Ferrucci. Drs Marc Bonaca, Naomi Hamburg, and Mark Creager discuss medical therapies currently available to improve outcomes in patients with PAD. In a similar vein, Drs Joshua Beckman, Peter Schneider, and Michael Conte cover the recent advances in revascularization for peripheral artery disease. Cindy St. Hilaire:        Racial and ethnic disparities in PAD is discussed by Drs Eddie Hackler, Naomi Hamburg, and Khendi White Solaru. Drs Tom Alsaigh, Belinda Di Bartolo, Jocelyne Mulangala, Gemma Figtree, and Nicholas Leeper present their thoughts on optimizing the translational pipeline for patients with peripheral artery disease. New directions and therapeutic angiogenesis and arteriogenesis in PAD is covered by Drs Brian Annex and John Cooke. Drs Esther Kim, Jacqueline Saw, Daniella Kadian-Dodov, Melissa Wood, and Santhi Ganesh review sex-biased arterial diseases with clinical and genetic pleiotropy, focusing in on multi-focal fibromuscular dysplasia and spontaneous coronary artery dissection, which have a much higher prevalence in women. Cindy St. Hilaire:        Drs Matthew Fleming, Ling Shao, Klarissa Jackson, Joshua Beckman, Anna Burke, and Javid Moslehi cover the vascular impact of cancer therapies and focus on how cardiac and vascular sequelae of novel targeted cancer therapies can provide insights into cardiovascular biology. Epidemiology and genetics of venous thrombosis and chronic venous diseases is presented by Drs Richard Baylis, Nicholas Smith, Derek Klarin, and Eri Fukaya. Dr Stanley Rockson reviews advances in our understanding of lymphedema and the compendium concludes with an article by Drs Yogendra Kanthi, Meaghan E. Colling, and Benjamin Tourdot, which reviews, inflammation, infection, and venous thromboembolism. This comprehensive compendium on peripheral vascular disease is found in our June 11th issue. Cindy St. Hilaire:        So today, Drs Eric Small and Ryan Burke from the University of Rochester Medical Center are with me to discuss their study Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. This article is in our May 28th issue of Circ Res. So thank you both for joining me today. Eric Small:                  Thanks Cindy, for having us. Excited to talk about our research with you. Ryan Burke:                Yeah, thank you very much for having us. Cindy St. Hilaire:        Absolutely. So fibrosis, it's essentially a wound healing mechanism, it's where connective tissue replaces the innate tissue of the organ system that it's happening in. It's really a component of many disease states. As far as I know, treatment options are pretty limited or really non-existent except in a couple rare cases, and in particular, your study, as it's in Circ Research, is focused on cardiomyopathy and the fibrosis related to that. But before we dig into your findings, which is really focused on a great therapeutic angle, I really want to take a step back and ask about what we know about fibrosis or the fibrotic process itself, maybe in the context of the heart, and despite why it's relatively common, it's been so difficult to target in terms of either therapies or really just understanding some of the basic processes. Eric Small:                  Sure, I'd be happy to discuss this. So as you know, and you alluded to already, pathological fibrosis contributes to progression of many debilitating human diseases. So in injury response in many tissues or organs, including the heart, kidneys, lungs, even the skin, leads to a wound healing process and that wound healing process is meant to repair the tissue and that includes an inflammatory response and secretion of extracellular matrix that fortifies the structural integrity of the tissue. But you can imagine in the context of a heart, that has to beat 60 plus times per minute, any alterations to the biomechanical properties of that tissue can alter the function. Eric Small:                  So extracellular matrix, which is meant to improve the structural integrity of an injury, even in the heart, ultimately can lead to reduced cardiac function. So this extracellular matrix, and in the context of disease, this extracellular matrix is called fibrosis, can reduce the contractility and the relaxation of the heart. The relaxation of the heart is actually an important aspect in insufficient relaxation called diastolic dysfunction, is becoming a more prevalent disease phenotype and it is called heart failure with preserved ejection fraction. What we're finding and what some investigators are alluding to is that fibrosis is a major component of this disease, and so understanding how extracellular matrix is secreted, why it is deposited in the context of injury, especially in the context of the heart, why does that process not stop sufficiently and revert once the injury is repaired, is a really important basic science and clinical question. Cindy St. Hilaire:        So why, specifically, has fibrosis or cardiac fibrosis been so difficult to target therapeutically? Eric Small:                  From my point of view, one of the reasons that fibrosis, organ fibrosis in general, and especially within the heart, is hard to target is because I think we're understanding now that one of the major cellular sources of extracellular matrix in disease is the fibroblast. This cell type has been sort of underappreciated for many years and is coming to the forefront now of biomedical research. So fibroblasts until maybe 10 or 15 years ago were thought to be more of a structural component. Of course, they contribute to wound healing, but it was thought that they contribute mostly to structural integrity and homeostasis of the injury. It's becoming more apparent now that resident cardiac fibroblasts contribute to extracellular matrix deposition in disease. But these cell types are really plastic, phenotypically plastic cell, they respond to a lot of biomechanical stimuli, especially that are induced in the context of tissue injury or disease, and so they respond to mechanical stretch or cellular deformation, and they can respond to many secreted factors, especially the canonical factor that has been studied extensively, TGF-beta. Cindy St. Hilaire:        Which itself is extremely complicated, to say the least. Eric Small:                  Absolutely, and so it does so much, and they respond to factors that are really high up on this hierarchy, that do so many things that I think obviously targeting TGF-beta is not going to be really an efficacious therapeutic option. So understanding what's more downstream and much more specifically related to the fibroblast, I think is really important to come up with new therapeutics. Cindy St. Hilaire:        So in your quest to identify novel therapeutics, or even really understanding that below the surface signaling you just talked about, you developed a high-throughput screen. I think this is a term that we often use, but we don't really know the details of that term, like what does high-throughput actually mean when you're doing it with cells and disease models? Dr Eric Small:             Sure. So I think in our case, we really let the science lead the way when it came to the high-throughput screen. So I'm not a chemical biologist, I have never, before now, developed a high-throughput screen and the science just pointed me in this direction. So the basic science research related to fibroblast plasticity and what induces fibroblasts to secrete extracellular matrix in the context of disease, all culminated in this one reporter that I thought would be good for the assay. So maybe as a way of a little bit of background, one difficulty in understanding fibrosis and fibroblast plasticity is that there are no really unique specific markers for an activated fibroblast. So most of the markers that people say are myofibroblast markers, which is the term for an activated ECM-secreting fibroblast, are expressed in other tissues or cells. Probably the most used and best characterized marker of a myofibroblast, is the smooth muscle alpha-actin gene, which encodes the smooth muscle actin protein, which is highly up-regulated in myofibroblasts, but obviously is expressed in a lot of other cell types, including smooth muscle cells. Eric Small:                  So it is a good marker of a myofibroblast, but it's not unique to myofibroblasts. But, this smooth muscle alpha-actin gene allowed us to make inroads into better understanding how fibroblasts respond to different stimuli. So what we did was, in the lab, one of the earlier things that we did when I set up my lab as an independent investigator, was to try to develop a stable cell line that expressed this reporter in a way that we could easily assay. So we could do it with GFP or a luciferase reporter or something like that. We made a luciferase reporter of this smooth muscle actin myofibroblast, alpha-actin gene. So one important aspect of a screen is, especially in our screen, which we were looking for chemicals that would inhibit our reporter, that we would hope would be anti-fibrotic Eric Small:                  Our hope was that this reporter would actually, in some cases, lead to an anti-fibrotic compound, but an important aspect of this screen, which was, I think the original question, was to not come up with factors that would just kill fibroblasts, but come up with factors that would specifically inhibit smooth muscle actin and myofibroblast activation without being too toxic. We don't want to inject a toxic chemical into a person; we want to inject a chemical that would be specific to an activated myofibroblast. So that was the first consideration, is to make sure that these were not toxic compounds, but were acting specifically on the smooth muscle actin report. Cindy St. Hilaire:        So with this system, you were able to screen over 2000 compounds, it was like 2300 or something like that. From that 2000 compounds screen, you zeroed in on salinomycin and two other compounds that are in the same family, I think, of chemicals like polyether ionophores they were called, I think it was the top three were all this similar class. So that's probably unsurprising that similarly-structured chemicals have a similar function or phenotype, but it's also intriguing. So I'm wondering, what's known if anything, about this class of chemicals, have they been used in therapy or is there some kind of naturopathic history to salinomycin or these other compounds that maybe if we read more carefully, we would have got a hint before? Ryan Burke:                Salinomycin has a pretty storied history in the literature, but it's an odd history. It's a veterinary antibiotic. So it's actually used primarily in livestock management and it had really no approach in human science at all. Then it was discovered that salinomycin, its earliest contribution, was that it is a compound that is actually very selectively targeting cancer stem cells. So salinomycin has a very extensive literature in cancer. It affects a lot of relevant signaling pathways, it's actually where we got a lot of our insight as to what we should be evaluating in fibroblasts. Both, in terms of ... This is probably going to be a charged statement; but there's a lot of similarities in how ... Cancer cells, when they're metastasizing and activating and moving around, there's a lot of EMT involved in that, there's a lot of things that are very analogous to how fibroblasts activate in heart failure. Ryan Burke:                I'm not saying they're the same, that's the charge portion of it, but the pathways are often conserved. What we found is that salinomycin had been studied extensively in various models of both solid and blood tumors, and it was found that it was affecting a whole ton of signaling pathways and sparing others, which was actually some of the insight that we had about AKT signaling. In the heart, it seemed very easy to just apply that and say, "Well, activation of fibroblasts is largely dependent on signaling pathways like SMADs and p38 signaling, so let's see what salinomycin does to these pathways in fibroblasts," and it turned out that that wound up being a very fruitful avenue for exploration, because it does behave very similarly in fibroblasts to the way it behaves in cancer cells. We didn't really find a lot of discordance in those results. Ryan Burke:                This study was very iterative, right? So do the high-throughput screen, find the drug, then try a preclinical model in animals. Then when it worked quite well in the angiotensin, hypertension-induced remodeling, that's a pretty mild model, right? Give the mouse an MI, see if it works in that, because that's a much more serious remodeling and when it performed well there, it's like, "Wow, you really actually probably have something here." Cindy St. Hilaire:        Yeah, and that's a perfect segue for my next question really, was I wanted to ask about these different murine models. Like you identified this compound, now you want to test it. Could you maybe give us a little brief background on why you chose the models you did and the treatment regimens that you also tried? Ryan Burke:                Sure. When we began, we began with angiotensin infusion because it's a fairly mild remodeling. You get some hypertrophic remodeling of the heart, you get some proliferation and some mild fibrosis in the mouse model. We figured this would give us the best chance to see a signal versus noise. It turned out that the results were really striking. Even the mice that were given the condition that we expected to see nothing in, is the drug with a saline infusion, even that had effects that were consistent with the effects that were seen. Consistent in direction in terms of the overall morphology and function of the heart, consistent with what you were seeing with the normalization of that hypertrophic remodeling in the angiotensin model that also got the drug. So that was really interesting to us. It was just consistent all the way through. Ryan Burke:                We wound up having a meeting about it and we were like, "All right, we've done the preventative regimen. We've preloaded them and then run them through with the drug. Now let's see if we can reverse established remodeling." So we did that study and when that worked out okay, there was yet another discussion where it was like, "All right, are we doing this?" And it was a myocardial infarction study. Myocardial infarctions, that's really extensive remodeling with huge changes, both the macro and microstructures of the heart. There's a lot more of an inflammatory component involved in that. Ryan Burke:                So we weren't sure how this would perform and it turns out that it performs exactly as it performs in pressure overload. You see normalization in physiology. I think that's part of the power of this study is that you're looking at non-ischemic and ischemic heart failure models, you're looking at preventative and interventional regimens, and it's just consistently performing at a level. We wanted to check all of our boxes, really, with this. Cindy St. Hilaire:        Sure. Yeah, maybe salinomycin's going to be the new aspirin we pop when we're over 50. Ryan Burke:                I doubt it, it's worth $7 a kilogram. I very highly doubt anyone's licensing that. Eric Small:                  But I think it's interesting you say that because understanding the mechanism after you understand that it's efficacious is sort of a similar idea here. We don't necessarily know precisely what it's targeting to act as an anti-fibrotic in this case, and so there's a lot of work to be done on this compound. I'd like to reiterate something that Ryan actually said is that really interesting, at least in cells and in the animal models, that salinomycin doesn't have a huge impact on the heart or on cultured fibroblasts in the absence of, for example, TGF-beta stimulation or a disease mechanism. It's really when we have a disease that salinomycin blocks the activation of the myofibroblasts and prevents that from contributing to the disease. Cindy St. Hilaire:        Interesting. So that can really, at least in the case of maybe cardiomyopathy, would help target it to the heart. Eric Small:                  That would be the hope, yeah. Cindy St. Hilaire:        Yeah, that's great. Wow. Speaking of the heart, and you mentioned this in that first answer that you had about the fibroblast being kind of the forgotten child of the heart and the focus is really more the cardiomyocyte, but did this drug have any impact on the cardiomyocytes itself that are also probably exposed to this TGF-beta signaling, in the context of an injury? Eric Small:                  So this is where we have some interesting, but not anticipated, results. So we obviously performed a screen in fibroblasts to look for specific anti-fibrotic compounds and when we put this into animals into ischemic or non-ischemic models, especially in the ischemic model, we found a much better outcome than we would have expected from simply an anti-fibrotic. So for example, we saw that pretreatment of mice with salinomycin prior to myocardial infarction, almost completely abrogated, not completely, but highly significantly abrogated necrotic tissue formation. So when Ryan went back and looked at the percentage of heart that became necrotic, or ischemic, after myocardial infarction, it actually reduced the necrotic core significantly. So we do think it's acting on cell types other than the fibroblasts in the context of ischemic remodeling, and it does seem to induce potentially protective signaling pathways in cultured myocytes. So that's definitely an area that we'd be interested in pursuing in more detail. Ryan Burke:                So of course the question there is, and this is a totally fair question for people to evaluate, we're looking at an organ in which all the cell types are talking to each other. We know we've affected the fibroblasts in a certain way, and we know to a certain extent, from what we found, what we've done for the fibroblasts, and we know what that looked like as a result in myocytes, but who initiated that, right? Did we affect the myocyte and then fibroblasts changed? Or did we affect fibroblasts and myocytes changed? But those are important type questions. We've shown the changes, but how do we show the connections? I think that's the really interesting work that we're still doing. We even extended it a little bit to endothelial cells in the heart, because we were showing that there was sort of a preservation of vascularization in the MI model that was associated with salinomycin, and we wouldn't rule out that we were affecting endothelial cells as well. I mean, I think this is a subject for discussion in the field, in the future. Groundwork is there, it's time to move forward. Cindy St. Hilaire:        Yeah, that is so exciting, and it's also I guess the classic chicken and egg question of science. What's causing what? That's excellent. So what's next for this project? I mean, you just highlighted some other angles, endothelial cell, but is there plans to translate it to a clinical setting, especially because it's already used in humans, so there's all that safety data out there? What's the plan? Eric Small:                  So that's a really interesting question. So our collaborators here at the University, Colin Woeller, Patricia Sime, Rick Phipps, they have been involved in the study with us and they are interested in fibrosis in other aspects as well. So they're interested in lung fibrosis, idiopathic pulmonary fibrosis, ocular eye fibrosis, and they've found that in other situations, salinomycin can inhibit fibrotic disease remodeling, for example, in the eye and in the skin. So branching out into other animal models of fibrotic disease is one area that we'd like to pursue. One area that I'm really interested in looking at salinomycin would be, for example, in models of HFpEF to see whether salinomycin might be efficacious in limiting the progression of animal model HFpEF. These are now becoming more prevalent and so it'd be great to test that there. Eric Small:                  So I think probably with some of these small animal studies, it would lay the groundwork for larger animal studies as collaborations or with other investigators. Absolutely, I think that's where this could definitely go next. Ryan Burke:                Also, it's a high-throughput screen, right? It wasn't the only hit and so extending the screen outwards both ... So the screen was designed to pick up both anti and pro-fibrotic drugs. So pro-fibrotic drugs have applications in wound healing. It also gives us a hint as to if a drug has some unexpected side effects in large clinical populations, then we can look at that and say, "Oh, maybe we have mechanistic understanding of why this might be the case." I think you'll see some future explorations down that path as well in that study. Cindy St. Hilaire:        Well, I look forward to seeing all of them. This was a wonderful study. I'm more vascular biologist, but obviously being on Circ Res, I'm learning so much more about the heart, but this one, I just particularly love that you started with this crazy complex question of what the heck is going on and this high-throughput screen was just designed in such a way that it really narrowed down what was a huge amount of options to start with. So it was really elegantly done and I just love the story, so congrats to you both and I look forward to future publications. Eric Small:                  Thank you. I'm especially proud of this one because as a basic scientist and as a trained in graduate school as a developmental biologist, I was following the science and when this opportunity arose to try to make this high-throughput screen work, I mean, this was as clinically relevant as I could ever have imagined my lab becoming. I'm really proud that we're able to do that. Cindy St. Hilaire:        Absolutely. I know, it's something we always talk about, and this research can be translated to humans eventually, and you're almost there. That's great. Well, congrats again. Thank you both for taking the time today and I look forward to your future studies. Eric Small:                  Thank you, Cindy. Ryan Burke:                Yeah, thanks Cindy. Cindy St. Hilaire:        That's it for the highlights from the May 28th and June 11th issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Drs Eric Small and Ryan Burke. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on-the-go source for the most up-to-date and exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2021. The opinions expressed by the speakers of this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.  

Julia Banks was a successful corporate lawyer with a couple of decades of leadership under her belt. Not one to shy away from an argument, or a challenge, she felt the tug of politics around 5 years ago.In 2016 she decided it was time to try and toss out the Labor member for the Melbourne seat of Chisholm who'd held the seat for 17 years, Anna Burke… and win the federal seat for the Liberal party. And she did! The seat became known as the one seat in the one-seat majority, and the only seat won from Labor in the 2016 election.But her enthusiasm for morphing from lawyer to legislator soon turned sour. In fact worse. Julia found parliament and her party's power plays stank. What she later called out as ‘gender bias, bullying and intimidation' has since become a regular headline describing the current Australian government…. But back in 2018, when Julia quit the Liberal party and became an Independent, she was the first woman to so boldly turn on her own party. The move was described in the media as “a blistering farewell” amid chaos and political thuggery. What followed was a relentless attack on Julia Banks sanity … from death threats to numerous attempts to discredit her. Not only did she survive and fight back … she has now dedicated herself to tackling face-on the scourge of sexism inherent in Australian politics. See acast.com/privacy for privacy and opt-out information.

You’ve met Thirsty Kris, but could we interest you in meeting…Baby Tara? This week, our fearless hosts reach that point in every podcaster’s life where you Google and read things up on sites while you’re recording. Don’t worry, they’re not looking for recommendations. They’re full to brimming with them. Tara discusses the video game Children of Morta before standing behind her queer recommendation for the week, Nottingham but Anna Burke. And after Kris’ foray into Netflix’s The One, she shares that SHE WAS RIGHT and Dickinson (Apple TV) is as amazing as she thought. If you enjoy this episode, please consider buying Kris & Tara a Ko-fi! Also discussed: The World to Come https://www.doesthedogdie.com/does-an-lgbt-person-die The Lammy Awards (Lambda Literary) and the Foreword Indies Finalists The One (Netflix) Children of Morta (Nintendo Switch) A Long Way to a Small Angry Planet by Becky Chambers Get this episode's transcript

Join us as we talk to sapphic queer fiction author Anna Burke about books, what got her into writing, her favourite parts about Compass Rose, and her upcoming release, Sea Wolf. ★ Find Anna Burke at: Website: http://www.annahburke.com Twitter: https://twitter.com/annaburkeauthor Instagram: https://www.instagram.com/annaburkeauthor ★ Bywater Books: https://www.bywaterbooks.com ❤ Sea Wolf (Part 2 of Compass Rose) : https://www.bywaterbooks.com/product/sea-wolf-by-anna-burke ❤ Nigh Tide: https://www.amazon.com/dp/B08NWBRC4M ❤ Spindrift: https://www.amazon.com/dp/B08CQF3M3Z ★ Social channels: Facebook: https://www.facebook.com/groups/allstarsbookclub YouTube: https://www.youtube.com/channel/UCIV2pxeHcG00nCjFWvNKlIg Instagram(Z): https://www.instagram.com/zeesreadingnook/ Instagram (C): https://www.instagram.com/kamloth ❤Don't forget to subscribe to be notified of new updates!❤

They didn’t turn to salt, but holy shit what happened these last couple of weeks? Tara and Kris start off discussing the attempted American insurrection before getting into what they love. And this week? They love a lot. Dolly Parton, Anna Burke, Hades, Bridgerton, Nora Roberts (that fucking badass). Their official recommendations for this week are Tara’s favourite book of all time (Hoosier Daddy by Ann McMan and Salem West) and the TV show that captured Kris’s heart and attention (Wynonna Earp). It’s a good episode. And what did it cost them? Friends, apparently. Kris has no more friends now. They know what they did. Seriously. Listen to find out. This week, Tara and Kris queerly recommend: Scent by Kris Bryant The Murderbot Diaries by Martha Wells Nora Fucking Roberts Hades (Nintendo Switch) Songteller: My Life in Lyrics by Dolly Parton Bridgerton (Netflix) Spindrift by Anna Burke Football! (As long as our team is playing) Pride and Prejudice (the one with Colin Firth, aka the only real one) Hoosier Daddy by Ann McMan and Salem West Wynonna Earp ClexaCon Get this episode's transcript

Amanda and Jenn discuss good books about houseplants, family-focused romance, quirky characters, and more in this week’s episode of Get Booked. This episode is sponsored by TBR: Book Riot’s service for Tailored Book Recommendations, now available as a gift! and Sourcebooks. Subscribe to the podcast via RSS, Apple Podcasts, Spotify, or Stitcher. Feedback Ten Thousand Doors of January by Alix Harrow (rec’d by Eric) Broken Wings by L-J Baker,  Princess of Dorsa by Eliza Andrews, When Women Were Warriors by Catherine Wilson (the kindle version is free on Amazon!!), and everything Anna Burke has written (rec’d by Wynnde) Questions 1. Since it’s almost June, the Gay Month, today I wanna ask for some LGBT recs! In the past I’ve read The Price of Salt, My Lesbian Experience With Loneliness (RECOMMEND btw!!!), On Earth We’re Briefly Gorgeous, Brown, White, Black, The Song of Achilles, and probably others I can’t remember. I already have Ari & Dante Discover the Secrets of the Universe, Red, White & Royal Blue, Juliet Takes a Breath, Freshwater, An Unkindness of Ghosts, and It’s a Whole Spiel on my TBR. It would be great if you could recommend 1 fiction and 1 non-fiction, particularly looking for something by a female or nonbinary author, bonus points if they are NOT from the US/UK (or even Europe) as I’m trying to read about experiences other than my own. –Dee 2. COVID-19 Reading Recs: I am a healthcare worker, and this pandemic has been challenging both personally and professionally. My colleagues and I have been working 24/7 to support our community through this difficult time. I am proud to serve my patients, but I am feeling increasingly isolated as this pandemic stretches on. I am in a long distance marriage, and due to travel restrictions in place from my organization, I am not sure when I will be able to see my husband or my family again. I always turn to books in times of crisis, and am having trouble concentrating on my usual genres. What I am hoping for in my reading life is some light fluffy romance with lots of banter, particularly with depictions of strong sibling relationships and/or found families. Some comps would be the Bridgerton series or The Governess Game by Tessa Dare. I know this is a very specific request, and would appreciate any and all recommendations. Thank you so much! –Niki 3. Since quarantine started, I’ve been mostly craving mystery/thrillers and lately (after hearing you describe Death by Dumpling), I’ve been wanting to pick up some cozy mysteries! I love that they’re bingeable and that there’s usually tons more in the series. I think I’m gonna pick 5-10 cozies, read them all and choose my favorite to continue on. I love the Inspector Gamache series (not really a cozy), Riley Sagar thrillers, I recently loved The Good Marriage by Kimberly McCreight, The City We Became by NK Jemisin and the Southern Book Club’s Guide to Slaying Vampires. I don’t care to read much historical fiction. I’m always trying to read from a diversity of authors, especially women of color. What are your fave cozies? And do they need to be read in order? –Tara 4. TIME SENSITIVE: I am going on a trip to Charleston and Savannah, and would love some recommendations for books set in either/both of these places. I’ve already read Midnight in the Garden of Good and Evil. I am open to any genre and would love anything to get me excited about the upcoming trip! *Also would love any recommendations for independent bookstores in the area, if you know of any!* –Netta 5. My 13-year-old daughter and I are starting a mother-daughter book club for the two of us, thanks to our forced-pandemic-togetherness time. Especially with school ending soon, I hope this is a good way to have some structure as well as fun. We are starting with Pet, by Akwaeke Emezi, and I am looking for recommendations for what we should read next. Some of her favorite books are The Westing Game, The War that Saved my Life, and the Percy Jackson books. I read lots of fantasy, mystery, romance, and some literary fiction – recent faves include The Great Believers by Rebecca Makkai, CL Polk’s Kingston cycle books, and Gail Carriger’s Soulless series. My daughter requests nothing that would embarrass to her talk about with her mom (a little swearing is ok, but no explicit sex on the page), and neither of us like graphic violence. Thank you for your help! –Alicia 6. Hi! I love your show! I’ve gotten so many good quirky books with unusual characters or premises…like 1980s high school field hockey team dabbles in witchcraft…or characters like a wyverary (mother was a wyvern, father was a library)…or washed up rock band has to compete in universe-wide battle of the bands to prove that humans are sentient and save the planet? I enjoy most genres, so it’s not limited to fantasy! –Kaitlyn 7. Hi there! Recently I’ve become interested in house plants, and I’ve absolutely loved reading “How to Houseplant: A Beginner’s Guide to Making and Keeping Plant Friends” by Heather Rodino. I loved the author’s practical tips on finding the right light for your plants, watering, different kinds of soil, and what plant would be best for your space. I’m interested in learning more about plants (both indoor and outdoor) / gardening in general. I’d love to read something else that is along the same lines as “How to Houseplant.” Perhaps a step up from beginner but not quite expert. I’d love to hear any recommendations you might have! Thank you! –Katie Books Discussed I Don’t Want to Die Poor by Michael Arceneaux Disoriental by Négar Djavadi, transl. by Tina A. Kover True Pretenses by Rose Lerner (ownvoices Jewish hero, tw: depictions of anti-Semitism) The Rogue Not Taken (Scandal & Scoundrel series) by Sarah MacLean Aunty Lee’s Delights by Ovidia Yu (tw: violent homophobia) Land of Shadows by Rachel Howzel Hall The Invention of Wings by Sue Monk Kidd (tw slavery) Defending Angels by Mary Stanton (rec’d by Caitlin) Etiquette and Espionage by Gail Carriger Not Your Sidekick by CB Lee The Southern Book Club’s Guide to Slaying Vampires by Grady Hendrix (tw racism, harm to children) Gideon the Ninth by Tamsyn Muir Wild at Home by Hilton Carter (IG: @hiltoncarter) Happy Cactus by John Pilbeam Gardeners’ World with Monty Don

Welcome to episode 60 of the Lesbian Book Club with Clare Lydon as she interviews US author Anna Burke. Anna writes a crossover of fantasy and sci-fi, and more recently has turned her hand to romance. Her award-winning debut, “Compass Rose”, had lesbian pirates, and her latest, “Nottingham”, is a queer retelling of Robin Hood. Is there a strong theme throughout her books? Anna says: “I like to write strong female characters. Ones that you want to have sex with, but ones who might also kill you.” Clare also does a run-down of the Amazon Lesbian Fiction charts in the US & UK. Her new book, a co-write with TB Markinson, is due out on June 16th – title and cover reveal coming soon. If you’d like to get a free lesbian romance from Clare, head to www.clarelydon.co.uk/it-had-to-be-you and sign up for her VIP Readers’ Club! For more on the South Coast Lesfic Hang Out: https://sclho.wordpress.com/

This week, Andi and Lise chat with F/F fic reviewer extraordinaire Tara Scott, whose reviews you can find at The Lesbian Review, Lambda Literary and Smart Bitches, Trashy Books. She also hosts the podcast Les Do Books at the Lesbian Talk Show. We talk a bit of history of F/F fiction, found out what she’s reading and way into these days, and also what she sees as emerging trends in F/F fiction. Books that came up in our convo! Aurora Rey, Recipe for Love (audio and written); Anna Burke, Thorn; Courtney Milan, Mrs. Martin’s Incomparable Adventure; Ann Bannon’s Beebo Brinker series (HERSTORY!!!! And Tara chatted with Ann about lesbian pulp fiction on her podcast HERE); Lee Winter, Breaking Character; Elle Spencer, Casting Lacey; Rachel Spangler, In Development; Alyssa Cole, Once Ghosted, Twice Shy. Authors who write butch characters well: KD Williamson, Jenny Frame, Nell Stark, Rachel Spangler, Brenda Murphy Other authors who came up: Radclyffe, Rebekah Weatherspoon, Kat Sebastian, Meghan O’Brien The LGO crew and Tara also recommend Heather Rose Jones’ podcast, The Lesbian Historic Motif, so if you’re looking to write some F/F historical fiction, check it out. Lise’s shout-out this week was to Hugo-winning N.K. Jemisn’s collection of short stories, How Long ‘til Black Future Month? Tara’s is for looking forward to reading Tara Muir’s Gideon the 9th, which Andi and Lise love, and Andi’s shout-out is to the fact that she’s currently creating a character for a little DnD! https://lezgeekoutcast.files.wordpress.com/2019/10/lgo_64_tara_scott.mp3

The End of the World with Anna Burke  Les Do Books with Tara and guest Anna Burke This week, Tara is joined by author Anna Burke (Compass Rose, Thorn). Anna shares her journey with lesbian fiction and their conversation takes us on a tour through the end of the world, food truck romances, the perfect grilled cheese sandwich and even lesbians in space. It’s a wild ride, but through it all the constant for Anna is the importance of books and how they can lead to a kinder world. Enjoy! Check out Anna’s Recommendations The Stars Are Legion by Kameron Hurley Kushiel’s Dart by Jacqueline Carey How to Lose the Time War by Amal El-Mohtar and Max Gladstone Of Fire and Stars by Audrey Coulthurst, illustrated by Jordan Saia Spanish Surrender by Rachel Spangler 2 Degrees by Bev Prescott The Priory of the Orange Tree by Samantha Shannon Miranda in Milan by Katharine Duckett Check out Tara’s recommendations Marriage of Unconvenience by Chelsea M. Cameron Perfect Pairing by Rachel Spangler The Tiger Flu by Larissa Lai The Lady’s Guide to Celestial Mechanics by Olivia Waite Find Anna Burke online Website http://annahburke.com/ Twitter: https://twitter.com/annaburkeauthor Facebook: https://www.facebook.com/anna.burke.560 Instagram: https://www.instagram.com/annaburkeauthor/ Patreon: https://www.patreon.com/annaburkeauthor More info If you’ve enjoyed this episode, please consider contributing to the Patreon for The Lesbian Talk Show channel. You can see all of our reviews, top 10 lists and author profiles on TheLesbianReview.com and don’t forget to send your emails, questions and more to Tara@TheLesbianReview.com.

Compass Rose by Anna Burke and 2° by Bev Prescott are perhaps best categorized as climate fiction,or cli-fi. They are also suspenseful, thrilling, occasionally terrifying, and brilliantly written with memorable […] The post Sandra Moran Book Club-Burke-Prescott appeared first on KKFI.

Saturday Chronicle Live from Whitegate GAA hall on the 4th of May 2019. Part 2 with Marie McNamara and  Jacko Treacy, Revival of Community games, Anna Burke volunteering, Mayfly madness and book launch of town lands of Clonrush parish. 00.00 Michelle Kelly on the revival of Community games in the Mountshannon Whitegate area and also talks about her role as PRO of the Lackyle School Parents Association and the recent extols to the National school. 10.43 Queen of the Waterways Anna Bourke talks about her year and her trip off to foreign parts to Fiji volunteering with Visa Abroad. 17.33 Eleanor Solan talking about the madness that is the 5th month of the year and the arrival of the Mayfly 27.42 Mary O Leary and Bernadette Watson - talking about the recent launch of the book about the town lands of Clonrush parish

Newsdesk 20th April 2019 Weekly Update on News and events  taking place in East Clare, compiled by Ursula Hogan and read by Marie McNamara. Amongst the items covered this week are -[04.40] next Clare Active Agers guided walk takes place in Ogonnelloe on Thursday 25th April 2019. Ursula Hogan talks to Arlene White about the walk.  [15.20] Anna Burke from Whitegate, Queen of the Waterways talks to Ursula Hogan about her fundraising for Vesa abroad (volunteer eco students abroad.) Anna is going to Fiji on the 15th of July to help a local village with infrastructure and teaching.

How does the House of Representatives work? Host Adam Peacock sits down with former Speaker, Anna Burke, to discuss what goes on in the Lower House and her run-ins with Tony Abbott during Question Time.

— Asa Sevelius is principal of the Heath School in Brookline, Mass. — Clair Farley is the director of economic development at the San Francisco LGBT Center; Mia Satya is an employment services specialist with the center's Trans Employment Program. — Check out the results from our Out at Work survey, plus a whole bunch of resources for navigating being queer on the job. Special thanks to Mandy Naglich, Anna Burke, and Alison Morgenstern. Episode scoring by Jeremy Bloom with additional music by Drake Stafford ("Matte Black") and Evan Schaeffer ("Sisyphus"). Theme by Alexander Overington. Listen to our other Out at Work stories — #16: Let's Talk About Trump's Trans Ban— #19: The Pentagon's Secret Gaggle of Gays— #22: Does Your Boss Know You're Gay?— #24: Somewhat Out

Christian and Andrew review The Wheeler Centre’s one night only event Revolting and Ridiculous: A Roald Dahl Retrospective. The event took place at the Athenaeum Theatre on July 7th. "This year marks the 100th anniversary of Roald Dahl’s birth – so the Wheeler Centre will get revolting and ridiculous on stage with guests including Andy Griffiths, Jess McGuire, Kate McLennan, Tim Rogers, Anna Burke and more. They’ll wax nostalgic, perform extracts from Dahl’s vast body of work, delve into the recurring themes of his stories and discuss the life of this incomparable, sometimes controversial, author." - The Wheeler Centre website.See omnystudio.com/listener for privacy information.

Christian and Andrew review The Wheeler Centre’s one night only event Revolting and Ridiculous: A Roald Dahl Retrospective. The event took place at the Athenaeum Theatre on July 7th.  "This year marks the 100th anniversary of Roald Dahl’s birth – so the Wheeler Centre will get revolting and ridiculous on stage with guests including Andy Griffiths, Jess McGuire, Kate McLennan, Tim Rogers, Anna Burke and more. They’ll wax nostalgic, perform extracts from Dahl’s vast body of work, delve into the recurring themes of his stories and discuss the life of this incomparable, sometimes controversial, author." - The Wheeler Centre website.

ANNA BURKE Labor MP & Former Speaker of the House Feature interview: One of 20 Govt MP's retiring. Available for hire. Excels at negotiating, making impromptu speeches and managing a disorderly crowd.

Dr. Anna Burke presented this talk at the University of Louisville as she neared the end of her residency with us. Dr. Burke is trained in Osteopathic Medicine and her approach to low back pain is outstanding in a world that, as she says, often seems to use narcotics as a first line therapy. She has since been hired to the Internal Medicine faculty at the University of Michigan. Her faculty profile can be found here: http://www.uofmhealth.org/profile/3461/anna-marie-burke-do