Podcasts about McKay

Kidney cancer management is evolving. How are experts adapting? In this installment of BackTable Tumor Board, Dr. Brandon Manley (Urologic Oncology, Moffitt Cancer Center), Dr. Raquibul Hannan (Radiation Oncology, UT Southwestern), and Dr. Rana McKay (Medical Oncology, UC San Diego) join guest host Mark Ball (Urologic Oncology, National Cancer Institute) to share their multidisciplinary perspectives on challenging, real-world kidney cancer cases.---This podcast is supported by:Ferring Pharmaceuticalshttps://ad.doubleclick.net/ddm/trackclk/N2165306.5658203BACKTABLE/B33008413.420220578;dc_trk_aid=612466359;dc_trk_cid=234162109;dc_lat=;dc_rdid=;tag_for_child_directed_treatment=;tfua=;gdpr=${GDPR};gdpr_consent=${GDPR_CONSENT_755};gpp=${GPP_STRING_755};gpp_sid=${GPP_SID};ltd=;dc_tdv=1---SYNPOSISThe conversation covers diagnostic dilemmas, navigating the treatment options of surgery, systemic therapy, and radiation, and the importance of a multidisciplinary approach. Through detailed case reviews, the panel highlights practical pearls, emerging clinical trials, and collaborative approaches that exemplify modern kidney cancer care.---TIMESTAMPS0:00 - Introduction02:20 - Case 1 (Incidental Renal Mass)16:52 - Case 2 (Bilateral Renal Masses)37:22 - Case 3 (Locally Advanced Renal Mass)56:34 - Case 4 (Symptomatic, Metastatic Disease)01:14:00 - Final Takeaways

McKay explores the habits of self-made wealthy individuals in this week's episode of the Open Your Eyes podcast. Drawing insights from such entrepreneurs as Elon Musk, Ingvar Kamprad, Warren Buffett, Lucy Guo, and Chuck Feeney, the episode aims to extract actionable insights from their lives that we all can implement in our own.Noting that wealth is built on key behaviors, not just saving, McKay highlights the power of continuous learning, calculated risk-taking, and an unwavering commitment to a "winning strategy". He also explores the value of "urgency bias," doubling down on talents, and prioritizing time. Throughout this revelatory episode, our host stresses that true worth stems from contribution (as exemplified by Chuck Feeney's philanthropy), and guides listeners to appreciate the significance of these proven habits and cultivate a mindset for prosperity and satisfaction.Main Themes:Successful individuals avoid procrastination and act promptly.Embracing lifelong learning and constantly seeking knowledge is crucial.Willingness to take informed, calculated risks is a common trait.A relentless commitment to a clear, winning strategy sets them apart.They focus efforts and creativity on their greatest strengths.Prioritizing time, often investing money to save it, is key.Hiring and learning from experts is something they do readily.Find true worth and satisfaction in helping others and making a contribution.Entrepreneurial journeys often begin in their teenage years.Top 10 Quotes:"Most people think that great brands like Tesla just appeared, but not so.""Wealthy people are always learning.""Your mind is your greatest asset.""The truth is, you can always make money, but you can't always make more time.""I think most people could have work-life balance if they cut out where they waste their time.""They pay for expertise without hesitation.""The habits of wealthy individuals are not built on secret formulas or mere good fortune.""The compounding effect of such habits can redefine both financial outcomes and life satisfaction."Show Links:Open Your Eyes with McKay Christensen

(00:00) Weather and Golf Post Ryder Cup This chapter brings us to the picturesque Pine Canyon in Flagstaff, Arizona, where we share a mix of personal experiences and reflections on recent golf events. We recount the unexpected hailstorms and flooding in Arizona, painting a vivid picture of the unusual weather conditions that recently swept through the region. Amidst this backdrop, I took the opportunity to savor a quiet day on the golf course, capturing videos and appreciating the scenic beauty before the onset of winter. We then shift our focus to the Ryder Cup, highlighting the challenges faced by even the world's best golfers in alternate shot formats. The discussion emphasizes the psychological pressures of playing not just for oneself, but also for a partner and country. We explore how the European team's familiarity with match play contributed to their superior preparation and performance, leading to a decisive advantage in the initial rounds against the U.S. team. (12:08) Ryder Cup Crowd Behavior Discussion This chapter takes us through a candid conversation about golf, regional attitudes, and sportsmanship. Jeff Smith joins from Flagstaff, Arizona, as we discuss the challenge of playing at Bethpage Black, one of the toughest courses. We reminisce about Michael Michaelides, who worked there and his New York grit. The discussion turns to the notorious behavior of some New York fans during the Ryder Cup, reflecting on the negative stereotypes of the "ugly American" and sharing personal anecdotes from living in New York. We explore the tension between being a sports fan and maintaining respect, especially when witnessing the unprecedented face-off between the world's top two golfers. As someone who spent my teenage years in New York City, I share insights into the sometimes brusque nature of New Yorkers, illustrating the contrast with an amusing story about our move from Boston. (16:34) Golf Techniques This chapter offers a delightful blend of sports commentary and musical nostalgia. We share our appreciation for the professionalism of broadcasters Terry Gannon and Dan Hicks, while also distinguishing Dan Hicks from the country singer of the same name, known for his hit "How Can I Miss You When You Won't Go Away." Our discussion then transitions to the golf world, focusing on Brad Faxon's insightful commentary and the notable absence of Keegan Bradley from a major tournament despite being the 13th ranked player globally. We speculate on the challenges and pressures that might have influenced his decision not to play, and reflect on the relentless nature of armchair critics. Additionally, we ponder the minute differences in skill and precision that can determine success in golf, particularly during high-stakes competitions like the Ryder Cup. (32:07) Sound Analysis and Sporting Events This chapter explores the nuances of sound in golf, particularly how experienced caddies like Jim "Bones" McKay can discern the difference between an average and a perfect strike, as demonstrated through the example of PGA Tour winner Tyler Duncan. We also touch on travel experiences, discussing scenic and not-so-scenic routes across the United States, from the engaging landscapes of Sedona to the tedious drive from Phoenix to Palm Springs. Additionally, we reflect on the recent disappointment at the Ryder Cup, despite high expectations, and share plans for an upcoming road trip across the country. Alongside these discussions, there is an exciting mention of attending a concert, with a hint of humor regarding who the performers might be. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Kevin McKay preaches "The Promised King" from Zechariah 4, in this Sunday morning gathering of Grace Harbor Church.

We catch up with the author of Gold Under the Mānuka, which is about his family’s inspirational story on Mangaorapa Station in southern Hawke’s Bay.See omnystudio.com/listener for privacy information.

The Prime Minister discusses the government’s energy package, the overhaul of the earthquake-prone building system, lower interest rates, and why he thinks farmers are more positive. Plus, he mourns the loss of broadcaster and popular psychologist Nigel Latta, who died at 58, following a battle with cancer.See omnystudio.com/listener for privacy information.

Our Shanghai-based red meat expert is on day one of The Golden Week, an eight-day holiday in China where everyone goes travelling. He comments on whether this holiday is good news for New Zealand’s red meat and how changes in restaurant culture and a struggling economy are affecting our exports.See omnystudio.com/listener for privacy information.

A farmer and a foundation member of Fonterra discusses the upcoming farmer vote for the co-op's $4.22 billion sale of Mainland to Lactalis. Plus, what questions farmers have been asking Fonterra about the deal at the co-operative’s road shows.See omnystudio.com/listener for privacy information.

This shearing gun is back from Europe and Australia, and is looking forward to the new shearing and woolhandling competition season kicking off in New Zealand.See omnystudio.com/listener for privacy information.

Award-winning Sydney-based science and agricultural teacher on why he’s bringing a team of 39 students to New Zealand.See omnystudio.com/listener for privacy information.

We catch up with an award-winning rural journalist from Pongaroa, who takes a break from docking to chat with The Country.See omnystudio.com/listener for privacy information.

Fonterra's making the case to shareholders in a bid to sell off its iconic brands. French dairy giant Lactalis has agreed to pay $4.2 billion for the consumer business. The Country's Hamish McKay explained further. LISTEN ABOVESee omnystudio.com/listener for privacy information.

The profound impact of teaching on unlocking human potential is the subject of McKay's focus today, arguing that everyone, whether a parent, coach, or team leader, plays the role of a teacher. The episode delves into the lives of such inspirational educators and mentors as Jaime Escalante, who transformed his students' lives by believing in them against all odds, among many others.McKay reveals that the most effective teaching transcends simply conveying information. It's about creating human connection, seeing the potential in others before they see it in themselves, and providing the right tools for growth. He introduces two powerful teaching strategies: creating a "hook" or "cognitive anchor" to make learning relevant and memorable, and using "scaffolding"—a process of explaining, demonstrating, practicing, and evaluating—to build skills and confidence. Through the stories of Thomas Edison and the Wright brothers, he also illustrates the immense power of "learning by doing." This episode is the guide for anyone looking to inspire, lead, and help others reach their full potential.Main Themes:The essence of teaching is to help others discover their own potential.Great teachers see students for who they can become.Discipline, focus, and mentorship are as crucial as raw talent.Effective teaching uses "hooks" to anchor new information to existing knowledge.Scaffolding (explain, demonstrate, practice, evaluate) is a key model for building skills."Learning by doing" is one of the most powerful forms of education.The joy of teaching comes from the human connection and witnessing growth.Everyone is a teacher, with the ability to leave a lasting legacy.Reading aloud to children is a powerful tool for cognitive and emotional development.Top 10 Quotes:"If students don't have to challenge themselves, then there's no teaching, there's no learning going on, there's no potential. We're just babysitting.""I touch the future when I teach.""The joy of teaching and training comes from the human connection. It's about a bond between the trainer and the team member where encouragement can change the trajectory of life.""When you're teaching, you must create a meaningful and important hook.""Talent is nothing without discipline. You can't let raw ability carry you. Your mind has to lead the way.""Learning by doing is perhaps the best way to teach your team members.""He was a teacher who left a legacy for his children by this very small, simple habit.""Higher, Orville, higher!"Show Links:Open Your Eyes with McKay Christensen

Before going to social media or others, have you talked with The Lord about your health? This week, Kari sits down with Linden to unpack: ➡️ The toxic side of wellness culture ➡️ Why fear is the biggest toxin of all ➡️ How simple rhythms with God bring real peace ➡️ What it looks like to make Jesus your true foundation for healing  If you've ever felt overwhelmed, anxious, or stuck in your health journey… this conversation will encourage you to lay down the striving and rediscover freedom in Christ. Make sure to follow Linden on Instagram: @Lindenmckay  She's such an encouraging follow!   Book a Free Inquiry Call . We'd love to talk to you!   Pharmacist Kari Coody and Integrative Health Practitioner Jenn Patriarca host weekly conversations meant to cut through the overwhelm of alternative healthcare options. Simple, effective, easy ways to pursue health and gain an understanding without a prescription pad. It's time to simplify the process of healing.   Add us on Instagram: www.instagram.com/cornerstoneintgrativehealing  Check out our site: www.cornerstoneintegrativehealing.com  Watch us on YouTube: https://www.youtube.com/@cornerstoneintegrativehealth  Add us on Facebook: www.facebook.com/cornerstoneintegrativehealing.com  Send us an Email: hello@cornerstoneintegrativehealing.com  Free download: 10 questions that will change how you heal: https://cornerstone-integrative-healing.aweb.page/p/d574f3f9-7b70-4b84-a6e5-2272fe9aeab3      The information shared in this episode is not meant to be medical advice. Please speak to your healthcare provider about making any changes to your healthcare plan.  

McKay on Sport on the AB selection, track and field coverage going forward, six weeks till the Melbourne Cup, and the Devil’s Own golf tournament in Palmy!See omnystudio.com/listener for privacy information.

McKay returns today for an extensive exploration into how our responses to life's setbacks shape our journey. Drawing insights from the Harvard Study of Adult Development, he challenges conventional wisdom, arguing that our perspective transforms challenges from daunting "mountains" into manageable "molehills."McKay reveals happiness isn't predicted by wealth or IQ, but by an "adaptive coping style" - learning from failures to create growth, akin to turning "lemons into lemonade." This is exemplified by Bill Graham, who overcame immense hardship through helping others and embracing a positive outlook. The episode utilizes a "halftime" metaphor for life, urging listeners to assess, learn from past "plays," and strategize for moving forward, rather than dwelling on what cannot be changed. As you will hear, avoiding overreaction to minor inconveniences and fostering a positive "frame of reference" with supportive networks enables us to "fail forward."Main Themes:Our response to failure drives happiness.Adaptive coping matters more than wealth or IQ.Learn from mistakes; turn setbacks into chances.Friends and inspiration help overcome challenges.The halftime metaphor: review, adjust, plan ahead.Overreacting to small issues reduces happiness.Positive thoughts anchor our brain's frame of reference.Faith empowers us to overcome obstacles.Release small worries; value missteps for a content life.Top 10 Quotes:"Almost all failures are not mountains but molehills in the valley of life, unless we make them mountains.""It isn't so much what they started with, what mistakes they made, or what happened to them that influenced their happiness in life, it's what they did with what happened to them that mattered.""Learn to live in thankfulness, looking back at what you have had, and what you didn't have, and most of all, what you do have now.""The difference between average people and achieving people is their perception of and their response to failure.""A single event doesn't have to define who we are. Instead, we can consider our life over time and look at who we've become as a result of our cumulative choices.""This positive adaptation to life played a significantly greater role than genetics, wealth, race or other factors in determining how happy people were later in life.""Researchers in the study call this an 'adaptive coping style' and describe it as the capacity to turn lemons into lemonade and not turn molehills into mountains.""When we're in the midst of failure, we need to give our brain a framework based on true principles.""Halftime is perhaps the most important part of the game.""Let go of the small things. Value your small missteps, they make us better. Don't sweat the small stuff."Show Links:Open Your Eyes with McKay Christensen

Chris Olsen, the university librarian for BYU-Idaho, talks about the newly remodeled west wing of the McKay library on campus and the new features it offers.

Kevin McKay preaches "The Promised Priest" from Zechariah 3, in this Sunday morning gathering of Grace Harbor Church.

Cassie Lee & Jessica McKay — FKA The IIconics in WWE and now The IInspiration in TNA — sit down for an unfiltered, exclusive interview. From revealing their childhood wrestling crushes on The Rock and John Cena (yes, there was a cardboard cutout involved) to setting hard boundaries with fans at meet & greets, Cassie and Jess bring honesty, laughs, and plenty of spice. They open up about life as mothers in wrestling, their promise to never split as a tag team, training with Shawn Spears & Tyler Breeze at Flatbacks, and how TNA gives them the freedom WWE never did. Plus: Victory Road plans, advice for aspiring wrestlers, their kids' futures in the ring, and why they've been quietly training for Hollywood. Hosts: Branson Quirke & Roger Corral Learn more about your ad choices. Visit podcastchoices.com/adchoices

Introducing “The Four Heavies" - manipulation, intimidation, coercion, and deceit - in today's episode, McKay demonstrates the detrimental impact they can have on individuals and organizations. He argues that while these tactics may yield short-term results, they create unhealthy patterns in mental and emotional development, ultimately undermining trust and growth.McKay illustrates these effects with personal stories: Anna's anxiety from manipulation, Marcus's isolation from intimidation, and Lena's trust issues from deceit. He extends this to corporate failures like Enron and Wells Fargo, showing how "The Heavies" disrupt brain development and foster toxic cultures. Our host then offers actionable alternatives: focusing on potential, modeling calmness, and cultivating empathy. Join him today to transform your parenting and leadership for lasting success.Main Themes:"The Four Heavies" (manipulation, intimidation, coercion, deceit) are detrimental to individual development and organizational culture.Childhood experiences of "The Four Heavies" profoundly impact brain development, emotional regulation, and future relationships.Organizational cultures can mirror individual parenting styles, leading to systemic problems when built on "The Four Heavies."Focusing on the potential of others fosters growth and healthy relationships.Modeling calm, desired behavior creates a safe environment for emotional processing and learning.Empathy is a powerful tool for connection and leadership, leading to trust and attraction.Positivity correlates with success, even more than aptitude.Avoiding "The Four Heavies" leads to more effective leadership, greater satisfaction, and positive impact.Self-compassion is important as we strive for improvement.Top 10 Quotes:"The long-term effect of using ‘The Four Heavies' is extremely unhealthy.""Underneath the surface, we all have a richer, more valuable person.""When we see this potential, it's natural to lead genuinely and authentically.""Coercion uses fear or punishment to force behavior.""When individuals feel manipulated or unsafe, they seek healthier environments.""Being calm invites reasoning and thinking.""Positivity heavily correlates to predicting a person's success, even if they lacked aptitude."Show Links:Open Your Eyes with McKay Christensen

Ever walk into a room and instantly forget why you're there? Or struggle to find words you know are on the tip of your tongue? I have good news for you! You're not losing your mind.  Your brain is simply changing.In this episode, neuroscientist Dr. Sarah McKay reveals what's really behind midlife “brain fog” and why it's part of a powerful transformation. From hot flashes and sleep struggles to surprising cognitive strengths we gain in menopause, she shares what's happening inside the brain, as well as how to support it through the transition.You'll walk away with science-backed strategies, a fresh perspective on midlife cognition, and maybe even a laugh or two (yes, we talk creatine and the importance of laughing at ourselves in this season). This is a conversation that will leave you feeling reassured, informed, and ready to support and embrace your evolving brain.Connect with Dr. Sarah McKayGrab the Brain Health BooksInstagram: @drsarahmckayWebsite: www.drsarahmckay.comLike what you learned? Check out these other episodes!Beating the Brain Fog of Menopause5 Things My Sister Wants You to Know About PerimenopauseWhen Mental Health Meets Menopause with Dr. Stephanie Bayliss ND​​Why Healthcare Needs to Break Up with Diet & Wellness Culture with Dr. Sylvi Martin  What did you think of this episode? Click here and let me know!

Kevin McKay preaches "The Surveyor" from Zechariah 1:18-2:13, continuing our series in Zechariah, in this Sunday morning gathering of Grace Harbor Church.

We speak with the couple about BYU, mental health, and how Natalie's alma mater is rated lower than BYU Idaho.  Follow Jordan and McKay @ https://www.youtube.com/@JordanandMcKayKnow of a missing woman's case that needs attention? Contact us at someplaceunderneith@gmail.com.Some Place Under Neith produced and edited by Adam Wirtz and Last Podcast Network. Artwork by Kevin Conor Keller, intro song "Subway" by Lunachicks, remixed by Devin Castaldi-Micca.Subscribe to SiriusXM Podcasts+ on Apple Podcasts to listen to ad-free new episodes. Subscribe to SiriusXM Podcasts+ to listen to new episodes of Some Place Under Neith ad-free.Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

Kelly and Mark discuss this unforgettable episode. We Hope you enjoy it!  “Dr. Mike matches wits with a notorious Indian hater, Major Samuel Morrison, as she tries to mediate a peace treaty between Black Moon’s braves and the cavalry, which would include a full pardon for Sully and allow him to return home. Dying of consumption, Black Moon agrees to surrender if his braves are allowed safe passage to the reservation. Wellend Smith, an emissary sent by President Grant, sides with the Indians, but Maj. Morrison is determined to thwart the agreement and put them in prison. Dr. Mike and Sully must look toward Sgt. McKay for support in upholding the law.” Safe Passage originally aired on December 13, 1997 Now there’s a place to buy Dr QuinnCast Merchandise! https://www.etsy.com/shop/ForYourLittleHouse The post Safe Passage first appeared on Dr.QuinnCast Podcast.

A chat with Dr Jane McKay, a general internal medicine specialist who works with patients who suffer from Long Covid and ME/CFS.Thanks for listening. Don't forget to follow the podcast and leave a review!

This episode is sponsored by Deel.Ensure fair, consistent reviews with Deel's calibration template. Deel's free Performance Calibration Template helps HR teams and managers run more equitable, structured reviews. Use it to align evaluations with business goals,reduce bias in ratings, and ensure every performance conversation is fair, consistent,and grounded in shared standards.Download now: www.deel.com/nickdayMenopause at work is not a policy box to tick. In this HR L&D episode, Nick Day sits down with Fiona McKay, founder of The Menopause Maze, to unpack how menopause affects leadership performance, talent pipelines, and boardroom readiness. You will learn why a symptom-only lens misses the real career impacts, how the “invisible filter” quietly shapes who gets promoted, and what HR and L&D can do to turn menopause into a leadership advantage. We cover data-driven diagnostics, the No Pause Scorecard, manager upskilling, and confidential coaching routes that protect privacy while improving performance and retention. Watch to move from awareness to action and build an inclusive, high-performance culture that keeps your best women.Workplace Scorecard: https://www.themenopausemaze.com/menopause-at-work-scorecard-for-workplacesNick Day's LinkedIn: https://www.linkedin.com/in/nickday/Find your ideal candidate with our job vacancy system: https://jgarecruitment.ck.page/919cf6b9eaSign up to the HR L&D Newsletter - https://jgarecruitment.ck.page/23e7b153e7(00:00) Preview and intro (02:25) Who Fiona McKay is and her mission (The Menopause Maze)(04:07) Menopause as an overlooked strategic blind spot(06:49) Why HR/L&D must lead or risk stall and attrition(11:06) Myths, symptom distribution, and the “invisible filter”(14:01) Equipping senior women for boardroom performance(16:02) Succession planning when symptoms peak(18:02) Data point: 73% would move for a menopause career coach(20:27) No Pause Scorecard and data diagnostic explained(23:07) Confidential coaching routes for leaders (B2B and direct)(26:19) Designing lifecycle-aware leadership development(28:25) Talent attraction and Gen Alpha expectations(29:42) Practical L&D actions: on-demand learning and manager support(31:50) Four immediate actions for organisations(33:46) Culture, inclusion, and the ripple effect beyond work(37:00) HR L&D Vault: resource, lesson, and future advice

McKay explores the pervasive lies that shape our lives, from media misinformation to self-deception in this latest instalment of the Open Your Eyes podcast. Throughout the episode, he argues that, in an age of rampant falsehoods, developing critical thinking is essential for personal growth and success.To illustrate this, our host dissects such viral hoaxes as a fake Disney World policy change and a deceptive TikTok diet scam, showing how easily falsehoods spread. McKay also examines the profound gap between public perception and the reality of declining crime rates, revealing how political narratives can create powerful, albeit false, beliefs. Finally, he shares the inspirational journey of ballerina Misty Copeland, whose success came from rejecting the lies of her difficult circumstances and embracing the truth of her potential. Join McKay today and learn how biases and emotional responses make us vulnerable as he shares his guide to challenging limiting beliefs and seeking empowering truths. Main Themes:Misinformation in media guides our behavior.False perceptions directly influence our actions.Emotions and cognitive biases make us vulnerable to lies.Critical thinking is essential for discerning truth.The lies we tell ourselves are the most damaging.Surround yourself with truthful, supportive people.Facing the truth frees you to change and grow.Replace false narratives with empowering truths.We project our views, creating a false consensus.Faith and positive inputs are stable sources of truth.Top 10 Quotes:"With so much mistrust and confusion in the news today, how many lies do we believe?""We end up taking action or not taking action based on those misperceptions that we hold.""Some of the most dangerous lies we encounter are the ones we tell ourselves.""Proximity is power.""The people you spend time with will affect your dreams, mindset, and motivation.""People who really love you don't rejoice or focus on your wrongdoing, but they rejoice in the truth that you can be someone better.""The truth will set us free.""Recognize that the news sources we feed our mind will alter our beliefs and actions.""When you're surrounded by people who encourage and uplift you, believing in yourself becomes easier.""If we're going to walk with God, we need to be in agreement with Him, learning to think as He thinks with the truth."Show Links:Open Your Eyes with McKay Christensen

Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.”  Our full disclosures are available in the transcript of this episode.  And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%.  And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting.  So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL  for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course.  And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media:        @ASCO on X (formerly Twitter)        ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck  Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera    

This episode of the Amazing Cities and Towns Podcast sponsored by Bearing Advisors, Jim Hunt interviews Alicia McKay about local government from down under.    7 Steps to an Amazing City: Attitude Motivation Attention to Detail Zing Inclusiveness Neighborhood Empowerment Green Awareness  Thanks for listening and look forward to having you join us for the next episode.   Links Mentions During Show:  https://www.aliciamckay.co.nz/  ·       www.AmazingCities.org ·       www.AmazingCities.org/podcast to be a guest on the podcast   About Alicia McKay   I help people make smarter decisions, focus on what matters, and confidently work with change.   I'm an author, speaker, strategist, consultant and entrepreneur. I've worked on strategy, change, and leadership with 120+ organisations, from tiny charities and rural Councils to global corporations and federal agencies and I've helped thousands of leaders make better decisions and get better outcomes. My strategy models and decision frameworks are used worldwide to drive alignment and performance.   I have spent my career - and life - studying, practising, designing, facilitating, and implementing strategy. I have only become more enamoured of its transformative potential with time. Strategy is a levelling force, an asset to the underdog. Anyone with big aspirations and limited resources should be a strategist.   I bring a plain-talking, no-nonsense approach to strategy backed by years of experience, deep expertise, and genuine care. I'm not here to overcomplicate things but to help you create real change.     About Your Host, Jim Hunt: Welcome to the “Building Amazing Cities and Towns Podcast” … The podcast for Mayors, Council Members, Managers, Staff and anyone who is interested in building an Amazing City.   Your host is Jim Hunt, the author of “Bottom Line Green, How American Cities are Saving the Planet and Money Too” and his latest book, “The Amazing City - 7 Steps to Creating an Amazing City”   Jim is also the former President of the National League of Cities, 27 year Mayor, Council Member and 2006 Municipal Leader of the Year by American City and County Magazine.   Today, Jim speaks to 1000's of local government officials each year in the US and abroad.   Jim also consults with businesses that are bringing technology and innovation to local government.   Amazing City Resources:   Buy Jim's Popular Books: ·       The Entrepreneurial City: Building Smarter Governments through Entrepreneurial Thinking:   https://www.amazingcities.org/copy-of-the-amazing-city   ·       The Amazing City: 7 Steps to Creating an Amazing City:   https://www.amazingcities.org/product-page/the-amazing-city-7-steps-to-creating-an-amazing-city   ·       Bottom Line Green: How America's Cities and Saving the Planet (And Money Too)  https://www.amazingcities.org/product-page/bottom-line-green-how-america-s-cities-are-saving-the-planet-and-money-too   FREE White Paper: ·       “10 Steps to Revitalize Your Downtown”  www.AmazingCities.org/10-Steps   Hire Jim to Speak at Your Next Event: ·       Tell us about your event and see if dates are available at www.AmazingCities.org/Speaking   Hire Jim to Consult with Your City or Town: ·       Discover more details at https://www.amazingcities.org/consulting   Discuss Your Business Opportunity/Product to Help Amazing Cities: ·       Complete the form at https://www.amazingcities.org/business-development   A Special Thanks to Bearing Advisors for the support of this podcast:  www.BearingAdvisors.Net    

Kevin McKay preaches "Second Chances" from Zechariah 1:1-17, starting our series in Zechariah, in this Sunday morning gathering of Grace Harbor Church.

Frank McKay LIVE on LI in the AM w/ Jay Oliver by JVC Broadcasting

We're back with Season 6 of The Wine & Chisme Podcast! To kick things off, I'm joined by Sofia, the passionate Latina vintner behind Cramoisi Vineyard, located in Oregon's stunning Willamette Valley. In this episode, Sofia shares her journey from growing up in Chile surrounded by wine culture to becoming a vineyard owner just outside of Portland, OR. We talk about the challenges and triumphs of carving out space as a Latina in the wine industry, what makes Oregon Pinot Noir so special, and the deep connection between heritage, passion, and the land. What you'll hear in this episode: Sofia's journey from Chile to Oregon's wine country How Cramoisi Vineyard came to life and its focus on Pinot Noir The realities of being a Latina vintner in a traditionally Eurocentric industry Why storytelling and heritage matter in wine Advice for anyone dreaming of stepping into the wine world Grab a glass of your favorite vino and join us for this inspiring Season 6 premiere!

McKay returns today to conduct an exploration into the profound impact of having a clear vision for your future, arguing that a well-defined destination is not just a dream but a practical navigation tool that provides direction, fuels motivation, and builds resilience. Drawing upon compelling stories of adventurers, athletes, and innovators, he reveals that knowing where you want to end up is the first and most critical step in achieving personal and professional success, especially when facing overwhelming obstacles.To demonstrate this principle, McKay shares several powerful accounts of vision in action. He tells the story of Jessica Watson, a 16-year-old who, driven by a clear goal, became the youngest person to sail solo around the world despite a terrifying early crash and life-threatening storms. He recounts how dense fog at the 2010 PGA Championship neutralized the world's best golfers, proving that even top professionals are lost without a clear line of sight to their target. The episode also details the incredible journey of William Kamkwamba, a Malawian boy who built a windmill to power his village after his vision was sparked by a library book. Each story illustrates how a vivid mental picture of a desired outcome empowers individuals to make better decisions, overcome adversity, and turn the impossible into reality.Main Themes:A clear vision is an internal map that guides your choices and prevents you from drifting.Success is rarely an accident; it is almost always preceded by a compelling vision.Knowing your destination fuels the motivation and perseverance needed to overcome challenges.A well-defined vision acts as a filter, helping you make decisions that align with your long-term goals.You can navigate life's “foggy conditions” - uncertainty, fear, and discouragement - with a strong internal vision.Vision generates the faith required to take small, consistent actions that lead to monumental results.Leaders inspire greatness by helping others create and hold on to their own vision.Your ability to visualize success directly impacts your performance and your ability to act with courage.Break down enormous goals by focusing on the small, daily actions that move you toward your vision.Knowing where you are going allows you to recognize and celebrate progress, which is vital for long journeys.Top 10 Quotes:“Behind every achievement lies a clear, compelling vision.”“When we don't have a clear vision of where we want to land, we can't act with certainty or courage.”“Clarity about where you want to go prevents drift.”“A clear vision does more than provide direction; it also inspires sustained motivation.”“When you know where you're going, setbacks are not the end of the story.”“Leaders help others keep their vision and faith.”“Clarity is power, and vision is the first step towards turning dreams into reality.”“Small, faithful acts done repeatedly change the direction of business and life.”“If you can see it in your mind, you can hold it in your hand.”“If you can dream it, you can do it.”Show Links:Open Your Eyes with McKay Christensen

On this episode of the Dubuque Area Sports Podcast, Everybody's Favorite Coach — Coach Maneman — is joined by Landon McKay, one of the top returning playmakers for the Dubuque Hempstead Mustangs.Landon has been a steady force in the Hempstead passing game the last few years, leading the Mustangs in receptions, yards, and touchdown catches last season. Despite finishing 6–3 in 2024, the Mustangs narrowly missed the playoffs — and now McKay and his teammates are hungry to flip that script in 2025.In this episode, we cover:

SummaryIn this episode of Talk Commerce, Hamish McKay, CEO and co-founder of OrderEditing.com, shares his journey from intern to entrepreneur, discussing the challenges and successes of building a software solution for order management in e-commerce. He highlights the importance of addressing customer service pain points and the innovative features of their product that enhance the shopping experience. Hamish also shares insights on growth strategies, future enhancements, and the significance of personal branding in today's digital landscape.TakeawaysHamish McKay is the 24-year-old CEO and co-founder of OrderEditing.com.OrderEditing.com allows customers to edit their orders without contacting customer service.The idea for Order Editing came from Hamish's experience in customer service.The software significantly reduces customer service tickets for e-commerce brands.Hamish's journey involved learning from mentors and adapting to market needs.The company has grown rapidly, partnering with major e-commerce brands.Order Editing aims to reduce return rates in online shopping.Innovative features include upselling opportunities post-checkout.Hamish emphasizes the importance of personal branding on platforms like LinkedIn.The future roadmap includes enhancing address validation and checkout upsells.Chapters00:00Introduction to Hamish McKay and Order Editing03:08The Journey of Starting Order Editing05:35Growth and Challenges as a Young CEO07:48Understanding the Problem of Order Changes11:05Innovative Solutions for Order Editing14:47Future Roadmap and Features for Order Editing17:14Closing Thoughts and Personal Insights

In today's episode, McKay explores the idea of choosing to see the best in people and situations, presenting the argument that an individual's perspective is an active force that can shape outcomes. Using examples from politics, prisons, and creative studios, he explains how a decision to focus on potential rather than flaws can build connections and lead to unexpected results. To demonstrate this principle, McKay shares several stories about individuals who chose to see the best in others. He recounts the friendship between Nelson Mandela and his prison guard, Christo Brand, who saw each other's humanity within a system designed for division. He details how mentors who recognized hidden talent were instrumental for comedian Lucille Ball and high-jump innovator Richard Fosbury. The episode also covers how Abraham Lincoln turned a political opponent into an ally and how Kevin Costner's belief in a script helped get the film Field of Dreams made. Each account illustrates how one person's choice to see potential created an outcome that once seemed impossible.Main Themes:Seeing the best in others is a learnable skill that transforms your influence.Your perspective on people directly shapes how they react to you.Unlock greatness in others by focusing on their potential, not their flaws.Look past differences to forge powerful alliances and unlikely friendships.Find the hidden gift or lesson in every difficult circumstance.A positive outlook can turn a rejected idea into a celebrated masterpiece.Great leaders see the strength in rivals and turn them into allies.Encourage authenticity by helping others trust their unique instincts.Habitually seeing the best creates a positive ripple effect in your environment.Improve your life by asking, “What can this teach me?” instead of pretending everything is perfect.Top 10 Quotes:“The way you see people changes everything.”“If we chose to see the best in other people, there would be worlds that would open to us.”“There is a gift in every hardship; your job is to find it.”“Life just goes better when you see the best in things.”“When we see the best in others, in things, in circumstances, they change.”“He saw the goodness in Christo. And the best they saw in each other started to grow.”“If you'll see the potential, the best in others, you'll improve your influence as a person and coach.”“Lincoln had seen past his ego and competition to see the best in this man. And in doing so, won his loyalty and friendship for life.”“What if you tried, just for a short time, to only see the best in the people on your team?”“You just might change your future in the process.”Show Links:Open Your Eyes with McKay Christensen

Kevin McKay preaches "Seeking God's Smile" from Psalm 80, continuing our series "Psalms", in this Sunday morning gathering of Grace Harbor Church.

Ever felt like your culture change efforts are just… throwing spaghetti at the wall

It was fun to chat with another California photographer, Jeff Galinovsky, all about the business side of photography. He has been at it since 1988 (yep, with a Minolta Maxxum 7000!) and now runs a thriving business in high-volume sports, senior and family portraits, corporate branding, and events. He's a CPP, Master of Photography, President of the Professional Photographers of Sacramento Valley, and an instructor with McKay Photography Academy.His recent trip with McKay was to Mongolia, and you really want to see the amazing photos on his Facebook page!Jeff and I dig into what it really takes to go full-time in photography—spoiler: it's not about quitting on a whim. He shares how he prepared, got mentoring, leaned on professional organizations, and built a foundation that allowed him to succeed long-term.We also cover:Planning ahead and thinking big-picture for your businessMultiple streams of income vs. specializing (and why both can work)Business basics: legal setup, customer service, target market, marketing, and pricingWhy mentors, community, and continuous learning are game-changers If you want to grow a photography business that lasts for decades, this conversation will give you a roadmap.Find Jeff here:Website: jeffgalinovskyphotography.comEmail: jeff@jeffgalinovskyphotography.comLinkedIn: Jeff GalinovskyConnect with Photography Business Coach Luci Dumas: Website Email: luci@lucidumas.comInstagram FacebookYouTubeNew episodes drop every week — make sure to subscribe so you never miss an inspiring guest or a powerful solo episode designed to help you grow your photography business.

McKay delves into the liberating principle that success isn't bound by age or a rigid schedule in this latest instalment of the Open Your Eyes podcast. Throughout the episode, he drives home the point that, whether you're an early prodigy or a late bloomer, life's rewards go to those who have the courage to start, and to start again, no matter where they are on their journey.McKay brings this concept to life with the stories of a number of remarkable individuals, including the winding path of Marvel Comics creator Stan Lee, who found his true voice after 20 years in the business, and the story of Ray Kroc, who built the McDonald's empire in his fifties. He also delves into the lives of chef Julia Child, designer Vera Wang, and blind mountaineer Erik Weihenmayer, each of whom redefined their lives by starting something new long after others might have given up. These stories clearly demonstrate that the most important step is always the next one.Main Themes:It is never too early or too late to pursue your passion or reinvent yourself.Life rewards persistence, authenticity, and grit over perfect timing.Comparing your journey to others leads to paralysis and a false sense of being behind.Early success does not guarantee a simple path, just as a late start does not preclude greatness.Your past experiences, even the challenging ones, can provide the wisdom and depth needed for future success.The end of one chapter, like a job or a dream, is not the end of your story.Starting over is not a sign of failure; it is proof that you are still fighting for your future.Embrace the support of others, as encouragement is crucial when trying again.Your worth is not defined by a timeline, but by your courage to show up.The most powerful creative work often comes from pursuing what you truly believe in.Top 10 Quotes:"In the end, life doesn't care if you started early or late. It cares that you started and that you showed up.""Life is not a race, and you are not behind.""Your worth is not tied to how early or how clean your path has been.""Don't confuse loss with defeat. The end of one chapter doesn't mean the story's over, it just means the next one is ready to be written.""Starting over isn't failure, it's proof I'm still fighting.""Sometimes the most beautiful currents take longer to find.""Life rewards persistence, authenticity, and grit over perfect timing.""What matters is that you try again."Show Links:Open Your Eyes with McKay Christensen

Kevin McKay preaches "Money" from Proverbs, in this Sunday morning gathering of Grace Harbor Church.

From shaky evacuation logistics to underused heroes, Jack Baruzzini, Jeff Haecker, and Victor Lams debate “Inferno's” big swings—McKay's volcanic gambit, Weir's tense negotiations, and the episode's behind-the-scenes quirks. The post Inferno (SGA) appeared first on StarQuest Media.

Ritchie McKay, Liberty Men's Basketball HC by Ed Lane

We did it…100 EPISODES of the Gutted Horror Podcast!! Join hosts Tony and Aleece for a killer celebration packed with horror movie memories, fan-favorite moments, listener shoutouts, and bone-chilling surprises.Whether you're a long-time listener or finding us for the first time, this is the perfect gateway into our horror-obsessed world. From slasher classics to cult favorites, found footage frights to so-bad-it's-good gems, we've spent 100 episodes SPILLING OUR GUTS about the movies we love!

What does it truly mean to commit? This week, McKay explores the powerful principle of "putting your stake in the ground," an unwavering declaration of your chosen path. Our host illustrates that avoiding the "murky middle" of indecision and making a firm, whole-hearted commitment is what separates fleeting attempts from life-altering success.Bringing this concept to life through a series of unforgettable stories, McKay shares powerful lessons from a harrowing whitewater kayaking trip and the historic Oklahoma Land Rush. He also explores the incredible resolve of cancer research activist Terry Fox, the ancient wisdom of Japan's Tsunami Stones, and the late-in-life triumphs of polar explorer Barbara Hillary. Each story demonstrates how to stake your claim on your future and build the life you are meant to live.Main Themes:Understanding the "why" behind a process empowers you to see it through.Making a firm, public commitment to a goal increases your chances of achieving it.Avoid the "murky middle" of indecision, which leads to paralysis and unhappiness.Success requires a whole-hearted effort, not a half-hearted attempt.Adopt a "no matter what" attitude when pursuing a difficult goal.Postpone judgment on your progress by deciding that "today is not voting day."Our past failures can give us the clarity to finally commit to our true path.Our commitment and example can serve as a guide for future generations.It is never too late to put your stake in the ground and achieve the extraordinary.True power is unlocked when you commit entirely and without reservation.Top 10 Quotes:"Understanding changes everything. It empowers you.""The people that reach their goals are most often those that have put their stake in the ground and said, 'I'll do this, no matter what.'""Today is not voting day. Today is working day. Voting day is later.""Half-hearted effort is without staying power.""He promised to complete his run, even if he had to crawl every last mile.""I stopped pretending I was anything other than what I was. And I determined, more than I had ever determined to do what I was meant to do: to write.""You'll find that a whole-hearted effort will result in success."Show Links:Open Your Eyes with McKay Christensen

Mark dives into the Prophet David O. Mckay as a father, and his teachings on parenthood. Despite David O. Mckay's busy life as a church leader, apostle, and prophet; he was an incredible parent and husband, and made those duties his greatest priority. Check out Marks Book- No Other Success: The Parenting Practices of David O. Mckay on Amazon, for a deeper look into the life of President Mckay.

Dr. Sarah McKay is a neuroscientist, author, and science communicator passionate about making brain science accessible and practical. With a PhD in neuroscience, she specializes in exploring the female brain and its transformations across life stages. Her books, The Women's Brain Book and Baby Brain, delve into the neuroscience of health, hormones, and motherhood. She's also the director of The Neuroscience Academy, bridging the gap between cutting-edge research and everyday life. We talk about: - Dr McKay's passion for science communication - Her inspiration for writing her books - Understanding the brain and menopause - Advancements in menopause research - Challenges in menopause research and communication - The impact of menopause on cognition and mood - Menopause in the workplace - The need for reliable data and room for nuance - Lifestyle and menopause management - The need for humor in menopause - Future directions in menopause research  And lots more! If you want to understand what happens to our brains in midlife, this podcast is a must listen. If you enjoyed this episode, please subscribe, share it and leave us a 5* review on iTunes or wherever you're listening. Order the ebook or audiobook (narrated by Rachel) versions of Rachel's book, Magnificent Midlife: Transform Your Middle Years, Menopause And Beyond at magnificentmidlife.com/book The paperback can be purchased on Amazon or other online retailers: UK: https://www.amazon.co.uk/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ US & Canada: https://www.amazon.com/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ Australia: https://www.amazon.com.au/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ You can listen to all the other episodes and get the show notes at magnificentmidlife.com/podcast. Recommended by the Sunday Times. Feedspot #9 in 40 Best Midlife Podcasts and #7 in 60 Best Women Over 50 Podcasts You'll find lots of strategies, support, and resources to help make your midlife magnificent at magnificentmidlife.com. Check out Rachel's online Revitalize Experience, a 6-week intensive small group mentoring experience or 1-1 Midlife Mentoring.

The profound notion that each of us is born for a unique purpose comes under McKay's learned scrutiny in this week's episode of the Open Your Eyes podcast. Noting that true happiness isn't found in mere achievements, our host demonstrates that discovering and living this purpose, especially through serving others, is actually the key. The episode is filled with powerful and inspiring stories of individuals who turned immense challenges into their greatest strengths. From Kevin Briggs, the "Guardian of the Golden Gate Bridge," to one-legged NCAA wrestling champion Anthony Robles, and from Olympian Michael Phelps to autism advocate Dr. Temple Grandin, McKay breaks down how our past doesn't disqualify us but prepares us for our purpose. Listen in now to discover how to find your own reason for being and transform your perspective on life, challenges, and happiness.Main Themes:You were born for a purpose, and discovering it is the key to true happiness.Your past doesn't disqualify you from your purpose; it prepares you for it.Your unique differences can be your greatest strengths.Lasting change begins with changing the way you think, not just with willpower.True purpose is often found in using your story to help and serve others.You don't need perfect conditions to start living your purpose.Small acts of compassion can lead to world-changing innovations.Listen to the whisper that says, "Maybe I could do something."Challenges and mistakes can lead you to the very place you are meant to be.Happiness is found in the pursuit of purpose, not just the achievement of goals.Top 10 Quotes:"I don't think I was born with a disadvantage. I think I was born for a reason.""I realized my past didn't disqualify me from my purpose. It prepared me for it.""I think the world needs different kinds of minds to work together. My difference is my strength.""I found that winning gold medals wasn't my purpose. My purpose is helping people who struggle like I did.""Before I formed you in the womb, I knew you. Before you were born, I set you apart and gave you a purpose.""You are the way you are because you were born for a purpose.""The way you think determines the way you feel, and the way you feel influences the way you act.""We can't be what we can't see.""It's okay not to be okay."Show Links:Open Your Eyes with McKay Christensen

This episode will change how you understand your brain – and yourself. If you've ever felt like your brain is working against you – think brain fog, mood swings, and exhaustion – you're not crazy, you're not broken, and it's not your fault. Today, world-renowned neuroscientist Dr. Sarah McKay joins Mel for a groundbreaking conversation that will completely transform how you understand your brain. Dr. McKay has spent 30 years studying the brain. She holds a Doctorate in neuroscience from Oxford University and flew over 10,000 miles from Australia to sit down with Mel for this conversation. In this episode, she reveals the 3 factors that influence how your brain develops. She also  tells you how you can use that information to reset your brain for a better mood, more energy, and greater mental clarity. Whether you're a woman looking for answers about why your brain is freaking out during PMS, or you are forgetting things during pregnancy or menopause, this is a must listen. In this episode, you'll learn: -The 3 forces that shape your brain before you're even born and how they differ if you are male or female -What's actually happening in your brain during PMS, pregnancy, and menopause and why it's not what you think -What men need to know about the female brain and what it reveals about their own -The long-term impact of telling a young girl she's “not a math person” -Why your brain shrinks during pregnancy and how that helps your baby -The real role of hormones in memory, mood, and mental health What you'll learn today will give you a deeper, research-backed understanding of how the brain really works, and how powerful it truly is. This isn't about fixing your brain. It's about understanding it and learning how to work with it. For more resources, click here for the podcast episode page. If you liked the episode, check out this one next: The Body Reset: How Women Should Eat & Exercise for Health, Fat Loss, & EnergyConnect with Mel:  Get Mel's #1 bestselling book, The Let Them TheoryWatch the episodes on YouTubeFollow Mel on Instagram The Mel Robbins Podcast InstagramMel's TikTok Sign up for Mel's personal letter Subscribe to SiriusXM Podcasts+ to listen to new episodes ad-freeDisclaimer