Podcasts about McKay

Introducing “The Four Heavies" - manipulation, intimidation, coercion, and deceit - in today's episode, McKay demonstrates the detrimental impact they can have on individuals and organizations. He argues that while these tactics may yield short-term results, they create unhealthy patterns in mental and emotional development, ultimately undermining trust and growth.McKay illustrates these effects with personal stories: Anna's anxiety from manipulation, Marcus's isolation from intimidation, and Lena's trust issues from deceit. He extends this to corporate failures like Enron and Wells Fargo, showing how "The Heavies" disrupt brain development and foster toxic cultures. Our host then offers actionable alternatives: focusing on potential, modeling calmness, and cultivating empathy. Join him today to transform your parenting and leadership for lasting success.Main Themes:"The Four Heavies" (manipulation, intimidation, coercion, deceit) are detrimental to individual development and organizational culture.Childhood experiences of "The Four Heavies" profoundly impact brain development, emotional regulation, and future relationships.Organizational cultures can mirror individual parenting styles, leading to systemic problems when built on "The Four Heavies."Focusing on the potential of others fosters growth and healthy relationships.Modeling calm, desired behavior creates a safe environment for emotional processing and learning.Empathy is a powerful tool for connection and leadership, leading to trust and attraction.Positivity correlates with success, even more than aptitude.Avoiding "The Four Heavies" leads to more effective leadership, greater satisfaction, and positive impact.Self-compassion is important as we strive for improvement.Top 10 Quotes:"The long-term effect of using ‘The Four Heavies' is extremely unhealthy.""Underneath the surface, we all have a richer, more valuable person.""When we see this potential, it's natural to lead genuinely and authentically.""Coercion uses fear or punishment to force behavior.""When individuals feel manipulated or unsafe, they seek healthier environments.""Being calm invites reasoning and thinking.""Positivity heavily correlates to predicting a person's success, even if they lacked aptitude."Show Links:Open Your Eyes with McKay Christensen

Ever walk into a room and instantly forget why you're there? Or struggle to find words you know are on the tip of your tongue? I have good news for you! You're not losing your mind.  Your brain is simply changing.In this episode, neuroscientist Dr. Sarah McKay reveals what's really behind midlife “brain fog” and why it's part of a powerful transformation. From hot flashes and sleep struggles to surprising cognitive strengths we gain in menopause, she shares what's happening inside the brain, as well as how to support it through the transition.You'll walk away with science-backed strategies, a fresh perspective on midlife cognition, and maybe even a laugh or two (yes, we talk creatine and the importance of laughing at ourselves in this season). This is a conversation that will leave you feeling reassured, informed, and ready to support and embrace your evolving brain.Connect with Dr. Sarah McKayGrab the Brain Health BooksInstagram: @drsarahmckayWebsite: www.drsarahmckay.comLike what you learned? Check out these other episodes!Beating the Brain Fog of Menopause5 Things My Sister Wants You to Know About PerimenopauseWhen Mental Health Meets Menopause with Dr. Stephanie Bayliss ND​​Why Healthcare Needs to Break Up with Diet & Wellness Culture with Dr. Sylvi Martin  What did you think of this episode? Click here and let me know!

Kevin McKay preaches "The Surveyor" from Zechariah 1:18-2:13, continuing our series in Zechariah, in this Sunday morning gathering of Grace Harbor Church.

We speak with the couple about BYU, mental health, and how Natalie's alma mater is rated lower than BYU Idaho.  Follow Jordan and McKay @ https://www.youtube.com/@JordanandMcKayKnow of a missing woman's case that needs attention? Contact us at someplaceunderneith@gmail.com.Some Place Under Neith produced and edited by Adam Wirtz and Last Podcast Network. Artwork by Kevin Conor Keller, intro song "Subway" by Lunachicks, remixed by Devin Castaldi-Micca.Subscribe to SiriusXM Podcasts+ on Apple Podcasts to listen to ad-free new episodes. Subscribe to SiriusXM Podcasts+ to listen to new episodes of Some Place Under Neith ad-free.Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

Kelly and Mark discuss this unforgettable episode. We Hope you enjoy it!  “Dr. Mike matches wits with a notorious Indian hater, Major Samuel Morrison, as she tries to mediate a peace treaty between Black Moon’s braves and the cavalry, which would include a full pardon for Sully and allow him to return home. Dying of consumption, Black Moon agrees to surrender if his braves are allowed safe passage to the reservation. Wellend Smith, an emissary sent by President Grant, sides with the Indians, but Maj. Morrison is determined to thwart the agreement and put them in prison. Dr. Mike and Sully must look toward Sgt. McKay for support in upholding the law.” Safe Passage originally aired on December 13, 1997 Now there’s a place to buy Dr QuinnCast Merchandise! https://www.etsy.com/shop/ForYourLittleHouse The post Safe Passage first appeared on Dr.QuinnCast Podcast.

This episode is sponsored by Deel.Ensure fair, consistent reviews with Deel's calibration template. Deel's free Performance Calibration Template helps HR teams and managers run more equitable, structured reviews. Use it to align evaluations with business goals,reduce bias in ratings, and ensure every performance conversation is fair, consistent,and grounded in shared standards.Download now: www.deel.com/nickdayMenopause at work is not a policy box to tick. In this HR L&D episode, Nick Day sits down with Fiona McKay, founder of The Menopause Maze, to unpack how menopause affects leadership performance, talent pipelines, and boardroom readiness. You will learn why a symptom-only lens misses the real career impacts, how the “invisible filter” quietly shapes who gets promoted, and what HR and L&D can do to turn menopause into a leadership advantage. We cover data-driven diagnostics, the No Pause Scorecard, manager upskilling, and confidential coaching routes that protect privacy while improving performance and retention. Watch to move from awareness to action and build an inclusive, high-performance culture that keeps your best women.Workplace Scorecard: https://www.themenopausemaze.com/menopause-at-work-scorecard-for-workplacesNick Day's LinkedIn: https://www.linkedin.com/in/nickday/Find your ideal candidate with our job vacancy system: https://jgarecruitment.ck.page/919cf6b9eaSign up to the HR L&D Newsletter - https://jgarecruitment.ck.page/23e7b153e7(00:00) Preview and intro (02:25) Who Fiona McKay is and her mission (The Menopause Maze)(04:07) Menopause as an overlooked strategic blind spot(06:49) Why HR/L&D must lead or risk stall and attrition(11:06) Myths, symptom distribution, and the “invisible filter”(14:01) Equipping senior women for boardroom performance(16:02) Succession planning when symptoms peak(18:02) Data point: 73% would move for a menopause career coach(20:27) No Pause Scorecard and data diagnostic explained(23:07) Confidential coaching routes for leaders (B2B and direct)(26:19) Designing lifecycle-aware leadership development(28:25) Talent attraction and Gen Alpha expectations(29:42) Practical L&D actions: on-demand learning and manager support(31:50) Four immediate actions for organisations(33:46) Culture, inclusion, and the ripple effect beyond work(37:00) HR L&D Vault: resource, lesson, and future advice

McKay explores the pervasive lies that shape our lives, from media misinformation to self-deception in this latest instalment of the Open Your Eyes podcast. Throughout the episode, he argues that, in an age of rampant falsehoods, developing critical thinking is essential for personal growth and success.To illustrate this, our host dissects such viral hoaxes as a fake Disney World policy change and a deceptive TikTok diet scam, showing how easily falsehoods spread. McKay also examines the profound gap between public perception and the reality of declining crime rates, revealing how political narratives can create powerful, albeit false, beliefs. Finally, he shares the inspirational journey of ballerina Misty Copeland, whose success came from rejecting the lies of her difficult circumstances and embracing the truth of her potential. Join McKay today and learn how biases and emotional responses make us vulnerable as he shares his guide to challenging limiting beliefs and seeking empowering truths. Main Themes:Misinformation in media guides our behavior.False perceptions directly influence our actions.Emotions and cognitive biases make us vulnerable to lies.Critical thinking is essential for discerning truth.The lies we tell ourselves are the most damaging.Surround yourself with truthful, supportive people.Facing the truth frees you to change and grow.Replace false narratives with empowering truths.We project our views, creating a false consensus.Faith and positive inputs are stable sources of truth.Top 10 Quotes:"With so much mistrust and confusion in the news today, how many lies do we believe?""We end up taking action or not taking action based on those misperceptions that we hold.""Some of the most dangerous lies we encounter are the ones we tell ourselves.""Proximity is power.""The people you spend time with will affect your dreams, mindset, and motivation.""People who really love you don't rejoice or focus on your wrongdoing, but they rejoice in the truth that you can be someone better.""The truth will set us free.""Recognize that the news sources we feed our mind will alter our beliefs and actions.""When you're surrounded by people who encourage and uplift you, believing in yourself becomes easier.""If we're going to walk with God, we need to be in agreement with Him, learning to think as He thinks with the truth."Show Links:Open Your Eyes with McKay Christensen

Dr. Pedro Barata and Dr. Rana McKay discuss the integration of innovative advances in molecular imaging and therapeutics to personalize treatment for patients with renal cell and urothelial carcinomas. TRANSCRIPT Dr. Pedro Barata: Hello, I'm Dr. Pedro Barata, your guest host of By the Book, a podcast series featuring insightful conversations between authors and editors of the ASCO Educational Book. I'm a medical oncologist at University Hospitals Seidman Cancer Center and an associate professor of medicine at Case Western Reserve University in Cleveland, Ohio. I'm also an associate editor of the ASCO Educational Book. Now, we all know the field of genitourinary cancers (GU) is evolving quite rapidly, and we have new innovations in molecular imaging as well as targeted therapeutics. Today's episode will be exploring novel approaches that are transforming the management of renal cell and urothelial carcinomas and also their potential to offer a more personalized treatment to patients. For that, joining for today's discussion is Dr. Rana McKay, a GU medical oncologist and professor at University of California San Diego. Dr. McKay will discuss her recently published article titled, “Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas.”  Our full disclosures are available in the transcript of this episode.  And with that, Rana McKay, great to have you on the podcast today. Dr. Rana McKay: Oh, thank you so much, Dr. Barata. It's really wonderful to be here with you. So, thanks for hosting. Dr. Pedro Barata: No, thanks for taking the time, and I'm looking forward to this conversation. And by the way, let me start by saying congrats on a great article in the Educational Book. Really super helpful paper. I'm recommending it to a lot of the residents and fellows at my own institution. I would like to first ask you to kind of give our listeners some context of how novel approaches in the molecular imaging as well as targeted therapeutics are actually changing the way we're managing patients with GU, but specifically with renal cell carcinoma and urothelial carcinoma. So, what are the areas you would call out as like being big areas for innovation in this context, and why are they important? Dr. Rana McKay: Very good question. And I think this is really what this article highlights. It highlights where are we going from an imaging diagnostics standpoint? Where are we going from a therapeutic standpoint? And I think if we have to step back, from the standpoint of diagnostics, we've seen PET imaging really transform diagnostics in prostate cancer with the advent of PSMA PET imaging, and now PSMA PET imaging is used as a biomarker for selection for theranostics therapy. And so, we're starting to see that enter into the RCC landscape, enter into the urothelial cancer landscape to a lesser extent. And I think it's going to potentially be transformative as these tools get more refined. I think when we think about therapeutics, what's been transformative most recently in the renal cell carcinoma landscape has been the advent of HIF2α inhibition to improve outcomes for patients. And we have seen the approval of belzutifan most recently that has reshaped the landscape. And now there's other HIF2α inhibitors that are being developed that are going to be further important as they get refined. And lastly, I think when we think about urothelial carcinoma, the greatest transformation to treatment in that context has been the displacement of cisplatin and platinum-based chemotherapy as a frontline standard with the combination of enfortumab vedotin plus pembrolizumab. And we've seen antibody-drug conjugates really reshape treatment and tremendously improve outcomes for patients. So, I think those are the three key areas of interest. Dr. Pedro Barata: So with that, let's focus first on the imaging and then we'll get to the therapeutic area. So, we know there's been a paradigm shift, really, when prostate-specific targets emerged as tracers for PET scanning. And so, we now commonly use prostate-specific membrane antigen, or PSMA-based PET scanning, and really transform how we manage prostate cancer. Now, it appears that we're kind of seeing a similar wave in renal cell carcinoma with the new radiotracer against the target carbonic anhydrase IX. What can you tell us about this? And is this going to be available to us anytime soon? And how do you think that might potentially change the way we're managing patients with RCC today? Dr. Rana McKay: First, I'll step back and say that in the context of PSMA PET imaging, we have actually been able to better understand RCC as well. So, we know that PSMA is expressed in the neovasculature of tumors, and it can actually be used to detect renal cell carcinoma tumors. It has a detection rate of about 84% when used for detection. And so, you know, I don't think it's just restricted to carbonic anhydrase IX, but we will talk about that. So, PSMA expressed in the neovasculature has a detection rate of around 84%, particularly if we're looking at clear cell RCC. CAlX is overexpressed in clear cell RCC, and it's actually used in diagnosing renal cell carcinoma when we think of CAlX IHC for diagnosing clear cell RCC. And now there are CAlX PET tracers. The first foray was with the ZIRCON study that was actually an interestingly designed study because it was designed to detect the likelihood of PET imaging to identify clear cell RCC. So, it was actually used in the early diagnostics setting when somebody presents with a renal mass to discriminate that renal mass from a clear cell versus a non-clear cell, and it was a positive study. But when I think about the potential application for these agents, you know, I think about the entire landscape of renal cell carcinoma. This is a disease that we do treat with metastasis-directed therapy. We have certainly seen patients who've undergone metastasectomy have long, durable remissions from such an approach. And I think if we can detect very early onset oligometastatic disease where a metastasis-directed therapy or SABR could be introduced - obviously tested in a trial to demonstrate its efficacy - I think it could potentially be transformative. Dr. Pedro Barata: Wonderful. It's a great summary, and I should highlight you are involved in some of those ongoing studies testing the performance of this specific PET scanning for RCC against conventional imaging, right? And to remind the listeners, thus far, for the most part, we don't really do FDG-PET for RCC. There are some specific cases we do, but in general, they're not a standard scanning. But maybe that will change in the future. Maybe RCC will have their own PSMA-PET. And to your point, there's also emerging data about the role of PSMA-PET scanning in RCC as well, as you very elegantly summarized. Wonderful. So, let me shift gears a little bit because you did, in your introduction, you did highlight a novel MOA that we have in renal cell carcinoma, approved for use, initially for VHL disease, and after that for sporadic clear cell renal cell carcinoma. We're talking about hypoxia-inducible factor 2-alpha inhibitors, or HIF2α inhibitors, such as belzutifan. But there's also others coming up. So, as a way to kind of summarize that, what can you tell us about this breakthrough in terms of therapeutic class, this MOA that got to our toolbox of options for patients with advanced RCC? Tell us a little bit what is being utilized currently in the management of advanced RCC. And where do you see the future going, as far as, is it moving early on? Is it getting monotherapy versus combinations? Maybe other therapies? What are your thoughts about that? What can you tell us about it? Dr. Rana McKay: Belzutifan is a first-in-class HIF2α inhibitor that really established clinical validation for HIF2α as a therapeutic target. When we think about the activity of this agent, the pivotal LITESPARK-005 trial really led to the approval of belzutifan in patients who were really heavily pretreated. It was patients who had received prior IO therapy, patients who had received prior VEGF-targeted therapy. And in the context of this study, we saw a median PFS of 5.6 months, and there did seem to be a tail on the curve when you looked at the 12-month PFS rate with belzutifan. It was 33.7% compared to 17.6% with everolimus. And then when we look at the response rate, it was higher with belzutifan on the order of 22-23%, and very low with everolimus, as we've previously seen. I think one of the Achilles heels of this regimen is the primary PD rate, which was 34% when used in later line. There are multiple studies that are testing belzutifan in combination across the treatment landscape. So, we have LITESPARK-011, which is looking at the combination of belzutifan plus lenvatinib in the second-line setting. We've got the MK-012 [LITESPARK-012] study, which is looking at belzutifan in various combinations in the frontline setting. So there is a combination with IO plus belzutifan. And so this is also being looked at in that context. And then we also have the LITESPARK-022 study, which is looking at pembrolizumab with belzutifan in the adjuvant setting. So there's a series of studies that will be exploring belzutifan really across the treatment landscape. Many of these studies in combination. Additionally, there are other HIF2α inhibitors that are being developed. We have casdatifan, which is another very potent HIF2α inhibitor. You know, I think pharmacologically, these are different agents. There's a different half-life, different dosing. What is going to be the recommended phase 3 dose for both agents, the EPO suppression levels, the degree of EPO suppression, and sustainability of EPO suppression is very different. So, I think we've seen data from casdatifan from the ARC-20 trial from monotherapy with a respectable response rate, over 30%, primary PD rate hovering just around 10%.  And then we've also seen data of the combination of casdatifan with cabozantinib as well that were recently presented this year. And that agent is also being tested across the spectrum of RCC. It's being looked at in combination with cabozantinib in the PEAK-1 study, and actually just at the KCRS (Kidney Cancer Research Summit), we saw the unveiling of the eVOLVE-RCC trial, which is going to be looking at a volrustomig, which is a PD-1/CTLA-4 inhibitor plus casdatifan compared to nivo-ipi in the frontline setting.  So, we're going to see some competition in this space of the HIF2α inhibitors. I think when we think of mechanism of action in that these are very potent, not a lot of off-target activity, and they target a driver mutation in the disease. And that driver mutation happens very early in the pathogenesis. These are going to be positioned much earlier in the treatment landscape. Dr. Pedro Barata: All these studies, as you're saying, look really promising. And when we talk about them, you mentioned a lot of combinations. And to me, when I think of these agents, it makes a lot of sense to combine because there's not a lot of overlapping toxicities, if you will. But perhaps for some of our listeners, who have not used HIF2α inhibitors in practice yet, and they might be thinking about that, what can you tell us about the safety profile? How do you present it to your patients, and how do you handle things like hypoxia or anemia? How do you walk through the safety profile and tolerability profile of those agents like belzutifan? Dr. Rana McKay: I think these drugs are very different than your traditional TKIs, and they don't cause the classic symptoms that are associated with traditional TKIs that many of us are very familiar with like the rash, hand-foot syndrome, hypertension, diarrhea. And honestly, these are very nuanced symptoms that patients really struggle with the chronicity of being on a chronic daily TKI. The three key side effects that I warn patients about with HIF2α inhibitors are: (1) fatigue; (2) anemia; and (3) hypoxia and dysregulation in the ability to sense oxygen levels. And so, many of these side effects - actually, all of them - are very dose-dependent. They can be very well-managed. So, we can start off with the anemia. I think it's critically important before you even start somebody on belzutifan that you are optimizing their hemoglobin and bone marrow function. Make sure they don't have an underlying iron deficiency anemia. Make sure they don't have B12 or folate deficiency. Check for these parameters. Many patients who have kidney cancer may have some hematuria, other things where there could be some low-level blood loss. So, make sure that those are resolved or you're at least addressing them and supplementing people appropriately. I monitor anemia very closely every 3 to 4 weeks, at least, when people start on these medications. And I do initiate EPO, erythropoietin, should the anemia start to worsen. And I typically use a threshold of around 10g/dL  for implementing utilization of an EPO agent, and that's been done very safely in the context of the early studies and phase 3 studies as well. Now, with regards to the hypoxia, I think it's also important to make sure that you're selecting the appropriate individual for this treatment. People who have underlying COPD, or even those individuals who have just a very high burden of disease in their lung, lymphangitic spread, pleural effusions, maybe they're already on oxygen - that's not an ideal candidate for belzutifan. Something that very easily can be done in the clinic before you think about initiating somebody on this treatment, and has certainly been integrated into some of the trials, is just a 6-minute walk test. You know, have the patient walk around the clinic with one of the MAs, one of the nurses, put the O2 sat on [measuring oxygen saturation], make sure they're doing okay. But these side effects, like I said, are very dose-dependent. Typically, if a patient requires, if the symptoms are severe, the therapy can be discontinued and dose reduced. The standing dose is 120 mg daily, and there's two dose reductions to 80 mg and 40 mg should somebody warrant that dose modification. Dr. Pedro Barata: This is relatively new, right? Like, it was not that we're used to checking oxygen levels, right? In general, we're treating these patients, so I certainly think there's a learning curve there, and some of the points that you highlight are truly critical. And I do share many of those as well in our practice. Since I have you, I want to make sure we touch base on antibody-drug conjugates as well. It's also been a hot area, a lot of developments there. When I think of urothelial carcinoma and renal cell carcinoma, I see it a little bit different. I think perhaps in urothelial carcinoma, antibody-drug conjugates, or ADCs, are somewhat established already. You already mentioned enfortumab vedotin. I might ask you to expand a little bit on that. And then in renal cell carcinoma, we have some ADCs as well that you include in your chapter, and that I would like you to tell us what's coming from that perspective. So, tell us a little bit about how do you see ADCs in general for GU tumors, particularly UC and RCC? Tell us a little bit about the complexity or perhaps the challenges you still see. At the same time, tell us about the successes. Dr. Rana McKay: Stepping back, let's just talk about like the principles and design of ADCs. So, most ADCs have three components. There's a monoclonal antibody that typically targets a cell surface antigen, which is conjugated by a linker, which is the second component, to a payload drug. And typically, that payload drug has been chemotherapy, whether it be topoisomerase or whether it be MMAE or other chemotherapeutic. We can start in the RCC space. There's been multiple antibody-drug conjugates that have been tested. There's antibody-drug conjugates to CD70, which is expressed on clear cell RCC. There's been antibody-drug conjugates to ENPP3, which is also expressed on RCC. There's antibody-drug conjugates to CDH6. And they have different payloads, like I said, whether it be topoisomerase I or other microtubule inhibitors. Now, when we think about kidney cancer, we don't treat this disease with chemotherapy. This disease is treated with immunotherapy. It is treated with treatments that target the VEGF pathway and historically has not been sensitive to chemo. So, I think even though the targets have been very exciting, we've seen very underwhelming data regarding activity, and in some context, seen increased toxicity with the ADCs. So, I think we need to tread lightly in the context of the integration and the testing of ADCs in RCC. We just came back from the KCRS meeting, and there was some very intriguing data about a c-Kit ADC that's being developed for chromophobe RCC, which is, you know, a huge unmet need, these variant tumors that really lack appropriate therapeutics. But I just caution us to tread lightly around how can we optimize the payload to make sure that the tumor that we're treating is actually sensitive to the agent that's targeting the cell kill. So, that's a little bit on the ADCs in RCC. I still think we have a long way to go and still in early testing. Now, ADCs for UC are now the standard of care. I think the prototypical agent, enfortumab vedotin, is a nectin-4-directed ADC that's conjugated to an MMAE payload and was the first ADC approved for advanced urothelial, received accelerated approval following the EV-201 trial, which was basically a multicenter, single-arm study that was investigating EV in cisplatin-ineligible patients with advanced urothelial carcinoma, and then ultimately confirmed in the EV-301 study as well. And so, that study ended up demonstrating the support superiority of EV from an overall survival standpoint, even PFS standpoint. Building on that backbone is the EV-302 study, which tested EV in combination with pembrolizumab versus platinum-based chemotherapy in the frontline setting. And that was a pivotal, landmark study that, like I said, has displaced platinum therapy as a frontline treatment for people with advanced urothelial carcinoma. And when we think about that study and the median overall survival and just how far we've come in urothelial cancer, the median OS with EV-pembro from that trial was 31 and a half months. I mean, that's just incredible. The control arm survival was 16 and a half months. The hazard ratio for OS, 0.47. I mean this is why when this data was presented, it was literally a standing ovation that lasted for several minutes because we just haven't seen data that have looked that good. And there are other antibody-drug conjugates that are being tested. We've all been involved in the saga with sacituzumab govitecan, which is a trophoblast cell surface antigen 2 (Trop-2) targeted ADC with a topoisomerase I payload. It was the second ADC to receive approval, but then that approval was subsequently withdrawn when the confirmatory phase 3 was negative, the TROPiCS-04 trial. So, approval was granted based off of the TROPHY-U-01, single-arm, phase 2 study, demonstrating a response rate of around 28% and a PFS of, you know, about 5 and a half months. But then failure to show any benefit from an OS standpoint. And I think there's a lot of controversy in the field around whether this agent still has a role in advanced urothelial carcinoma. And I think particularly for individuals who do not have molecular targets, like they're not HER2-amplified or have HER2-positivity or FGFR or other things like that. Dr. Pedro Barata: Fantastic summary, Rana. You were talking about the EV, and it came to mind that it might not be over, right, for the number of ADCs we use in clinical practice in the near future. I mean, we've seen very promising data for ADC against the HER2, right, and over-expression. It also can create some challenges, right, in the clinics because we're asking to test for HER2 expression. It's almost like, it's not exactly the same to do it in breast cancer, but it looks one more time that we're a little bit behind the breast cancer field in a lot of angles. And also has vedotin as a payload. Of course, I'm referring to disitamab vedotin, and there's very elegant data described by you in your review chapter as well. And it's going to be very interesting to see how we sequence the different ADCs, to your point as well. So, before we wrap it up, I just want to give you the opportunity to tell us if there's any area that we have not touched, any take-home points you'd like to bring up for our listeners before we call it a day. Dr. Rana McKay: Thank you so much. I have to say, you know, I was so excited at ASCO this year looking at the GU program. It was fantastic to see the progress being made, novel therapeutics that really there's a tremendous excitement about, not just in RCC and in UC, but also in prostate cancer, thinking about the integration of therapies, not just for people with refractory disease that, even though our goal is to improve survival, our likelihood of cure is low, but also thinking about how do we integrate these therapies early in the treatment landscape to enhance cure rates for patients, which is just really spectacular. We're seeing many of these agents move into the perioperative setting or in combination with radiation for localized disease. And then the special symposium on biomarkers, I mean, we've really come a long, long way. And I think that we're going to continue to evolve over the next several years. I'm super excited about where the field is going in the treatment of genitourinary malignancies. Dr. Pedro Barata: Oh, absolutely true. And I would say within the Annual Meeting, we have outstanding Educational Sessions. And just a reminder to the listeners that actually that's where the different teams or topics for the Educational Book chapters come from, from actually the educational sessions from ASCO. And your fantastic chapter is an example of that, right, focusing on advanced GU tumors. So, thank you so much, Rana, for taking the time, sharing your insights with us today on the podcast. It was a fantastic conversation as always. Dr. Rana McKay: My pleasure. Thanks so much for having me, Dr. Barata. Dr. Pedro Barata: Of course.  And thank you to our listeners for your time today. You will find the link to the article discussed today in the transcript of this episode. I also encourage you to check out the 2025 ASCO Educational Book. You'll find an incredible wealth of information there. It's free, available online, and you'll find, hopefully, super, super important information on the key science and issues that are shaping modern oncology, as we've heard from Dr. McKay and many other outstanding authors. So, thank you, everyone, and I hope to see you soon. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Pedro Barata @PBarataMD Dr. Rana McKay @DrRanaMcKay Follow ASCO on social media:        @ASCO on X (formerly Twitter)        ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Pedro Barata: Stock and Other Ownership Interests: Luminate Medical Honoraria: UroToday Consulting or Advisory Role: Bayer, BMS, Pfizer, EMD Serono, Eisai, Caris Life Sciences, AstraZeneca, Exelixis, AVEO, Merck, Ipson, Astellas Medivation, Novartis, Dendreon Speakers' Bureau: AstraZeneca, Merck, Caris Life Sciences, Bayer, Pfizer/Astellas Research Funding (Inst.): Exelixis, Blue Earth, AVEO, Pfizer, Merck  Dr. Rana McKay: Consulting or Advisory Role: Janssen, Novartis, Tempus, Pfizer, Astellas Medivation, Dendreon, Bayer, Sanofi, Vividion, Calithera, Caris Life Sciences, Sorrento Therapeutics, AVEO, Seattle Genetics, Telix, Eli Lilly, Blue Earth Diagnostics, Ambrx, Sumitomo Pharma Oncology, Esiai, NeoMorph, Arcus Biosciences, Daiichi Sankyo, Exelixis, Bristol Myers Squibb, Merck, Astrazeneca, Myovant Research Funding (Inst.): Bayer, Tempus, AstraZeneca, Exelixis, Bristol Myers Squibb, Oncternal Therapeutics, Artera    

This episode of the Amazing Cities and Towns Podcast sponsored by Bearing Advisors, Jim Hunt interviews Alicia McKay about local government from down under.    7 Steps to an Amazing City: Attitude Motivation Attention to Detail Zing Inclusiveness Neighborhood Empowerment Green Awareness  Thanks for listening and look forward to having you join us for the next episode.   Links Mentions During Show:  https://www.aliciamckay.co.nz/  ·       www.AmazingCities.org ·       www.AmazingCities.org/podcast to be a guest on the podcast   About Alicia McKay   I help people make smarter decisions, focus on what matters, and confidently work with change.   I'm an author, speaker, strategist, consultant and entrepreneur. I've worked on strategy, change, and leadership with 120+ organisations, from tiny charities and rural Councils to global corporations and federal agencies and I've helped thousands of leaders make better decisions and get better outcomes. My strategy models and decision frameworks are used worldwide to drive alignment and performance.   I have spent my career - and life - studying, practising, designing, facilitating, and implementing strategy. I have only become more enamoured of its transformative potential with time. Strategy is a levelling force, an asset to the underdog. Anyone with big aspirations and limited resources should be a strategist.   I bring a plain-talking, no-nonsense approach to strategy backed by years of experience, deep expertise, and genuine care. I'm not here to overcomplicate things but to help you create real change.     About Your Host, Jim Hunt: Welcome to the “Building Amazing Cities and Towns Podcast” … The podcast for Mayors, Council Members, Managers, Staff and anyone who is interested in building an Amazing City.   Your host is Jim Hunt, the author of “Bottom Line Green, How American Cities are Saving the Planet and Money Too” and his latest book, “The Amazing City - 7 Steps to Creating an Amazing City”   Jim is also the former President of the National League of Cities, 27 year Mayor, Council Member and 2006 Municipal Leader of the Year by American City and County Magazine.   Today, Jim speaks to 1000's of local government officials each year in the US and abroad.   Jim also consults with businesses that are bringing technology and innovation to local government.   Amazing City Resources:   Buy Jim's Popular Books: ·       The Entrepreneurial City: Building Smarter Governments through Entrepreneurial Thinking:   https://www.amazingcities.org/copy-of-the-amazing-city   ·       The Amazing City: 7 Steps to Creating an Amazing City:   https://www.amazingcities.org/product-page/the-amazing-city-7-steps-to-creating-an-amazing-city   ·       Bottom Line Green: How America's Cities and Saving the Planet (And Money Too)  https://www.amazingcities.org/product-page/bottom-line-green-how-america-s-cities-are-saving-the-planet-and-money-too   FREE White Paper: ·       “10 Steps to Revitalize Your Downtown”  www.AmazingCities.org/10-Steps   Hire Jim to Speak at Your Next Event: ·       Tell us about your event and see if dates are available at www.AmazingCities.org/Speaking   Hire Jim to Consult with Your City or Town: ·       Discover more details at https://www.amazingcities.org/consulting   Discuss Your Business Opportunity/Product to Help Amazing Cities: ·       Complete the form at https://www.amazingcities.org/business-development   A Special Thanks to Bearing Advisors for the support of this podcast:  www.BearingAdvisors.Net    

Kevin McKay preaches "Second Chances" from Zechariah 1:1-17, starting our series in Zechariah, in this Sunday morning gathering of Grace Harbor Church.

In this SEDI session, anarchist writer and editor Iain McKay delivers a brisk, idea-dense tour of Peter Kropotkin's science, ethics, and revolutionary politics—showing how the famed geographer's fieldwork and evolutionary arguments undergird a living anarchist program.McKay (lead author of An Anarchist FAQ and editor/translator of major Kropotkin editions) threads together mutual aid, syndicalism, and council organization with Kropotkin's critiques of state socialism and “red-in-tooth-and-claw” misreadings of Darwin.He contrasts T. H. Huxley's dour view of nature with Kropotkin's empirical case that cooperation is a force in evolution, then links that insight to the ethics and strategy of class struggle. Along the way he situates key works—Modern Science and Anarchy, Mutual Aid, Fields, Factories and Workshops, The State: Its Historic Role, and The Great French Revolution—as a coherent toolbox for building working-class power outside parliament and against bureaucratic socialism.McKay also speaks from the editor's desk: he assembled the comprehensive Direct Struggle Against Capital and produced new English editions of Modern Science and Anarchy and Words of a Rebel, restoring Kropotkin's revolutionary edge against later hagiography.This event is part of the Sam and Esther Dolgoff Institute (SEDI)'s ongoing series, bringing radical thinkers, organizers, and historians to deepen our understanding of the past and sharpen our interventions in the present.The Sam and Esther Dolgoff Institute (SEDI):https://www.dolgoffinstitute.com/Explore Iain McKay's work:An Anarchist FAQ – https://www.anarchistfaq.org/Author page – https://theanarchistlibrary.org/category/author/iain-mckay

Frank McKay LIVE on LI in the AM w/ Jay Oliver by JVC Broadcasting

We're back with Season 6 of The Wine & Chisme Podcast! To kick things off, I'm joined by Sofia, the passionate Latina vintner behind Cramoisi Vineyard, located in Oregon's stunning Willamette Valley. In this episode, Sofia shares her journey from growing up in Chile surrounded by wine culture to becoming a vineyard owner just outside of Portland, OR. We talk about the challenges and triumphs of carving out space as a Latina in the wine industry, what makes Oregon Pinot Noir so special, and the deep connection between heritage, passion, and the land. What you'll hear in this episode: Sofia's journey from Chile to Oregon's wine country How Cramoisi Vineyard came to life and its focus on Pinot Noir The realities of being a Latina vintner in a traditionally Eurocentric industry Why storytelling and heritage matter in wine Advice for anyone dreaming of stepping into the wine world Grab a glass of your favorite vino and join us for this inspiring Season 6 premiere!

McKay returns today to conduct an exploration into the profound impact of having a clear vision for your future, arguing that a well-defined destination is not just a dream but a practical navigation tool that provides direction, fuels motivation, and builds resilience. Drawing upon compelling stories of adventurers, athletes, and innovators, he reveals that knowing where you want to end up is the first and most critical step in achieving personal and professional success, especially when facing overwhelming obstacles.To demonstrate this principle, McKay shares several powerful accounts of vision in action. He tells the story of Jessica Watson, a 16-year-old who, driven by a clear goal, became the youngest person to sail solo around the world despite a terrifying early crash and life-threatening storms. He recounts how dense fog at the 2010 PGA Championship neutralized the world's best golfers, proving that even top professionals are lost without a clear line of sight to their target. The episode also details the incredible journey of William Kamkwamba, a Malawian boy who built a windmill to power his village after his vision was sparked by a library book. Each story illustrates how a vivid mental picture of a desired outcome empowers individuals to make better decisions, overcome adversity, and turn the impossible into reality.Main Themes:A clear vision is an internal map that guides your choices and prevents you from drifting.Success is rarely an accident; it is almost always preceded by a compelling vision.Knowing your destination fuels the motivation and perseverance needed to overcome challenges.A well-defined vision acts as a filter, helping you make decisions that align with your long-term goals.You can navigate life's “foggy conditions” - uncertainty, fear, and discouragement - with a strong internal vision.Vision generates the faith required to take small, consistent actions that lead to monumental results.Leaders inspire greatness by helping others create and hold on to their own vision.Your ability to visualize success directly impacts your performance and your ability to act with courage.Break down enormous goals by focusing on the small, daily actions that move you toward your vision.Knowing where you are going allows you to recognize and celebrate progress, which is vital for long journeys.Top 10 Quotes:“Behind every achievement lies a clear, compelling vision.”“When we don't have a clear vision of where we want to land, we can't act with certainty or courage.”“Clarity about where you want to go prevents drift.”“A clear vision does more than provide direction; it also inspires sustained motivation.”“When you know where you're going, setbacks are not the end of the story.”“Leaders help others keep their vision and faith.”“Clarity is power, and vision is the first step towards turning dreams into reality.”“Small, faithful acts done repeatedly change the direction of business and life.”“If you can see it in your mind, you can hold it in your hand.”“If you can dream it, you can do it.”Show Links:Open Your Eyes with McKay Christensen

SummaryIn this episode of Talk Commerce, Hamish McKay, CEO and co-founder of OrderEditing.com, shares his journey from intern to entrepreneur, discussing the challenges and successes of building a software solution for order management in e-commerce. He highlights the importance of addressing customer service pain points and the innovative features of their product that enhance the shopping experience. Hamish also shares insights on growth strategies, future enhancements, and the significance of personal branding in today's digital landscape.TakeawaysHamish McKay is the 24-year-old CEO and co-founder of OrderEditing.com.OrderEditing.com allows customers to edit their orders without contacting customer service.The idea for Order Editing came from Hamish's experience in customer service.The software significantly reduces customer service tickets for e-commerce brands.Hamish's journey involved learning from mentors and adapting to market needs.The company has grown rapidly, partnering with major e-commerce brands.Order Editing aims to reduce return rates in online shopping.Innovative features include upselling opportunities post-checkout.Hamish emphasizes the importance of personal branding on platforms like LinkedIn.The future roadmap includes enhancing address validation and checkout upsells.Chapters00:00Introduction to Hamish McKay and Order Editing03:08The Journey of Starting Order Editing05:35Growth and Challenges as a Young CEO07:48Understanding the Problem of Order Changes11:05Innovative Solutions for Order Editing14:47Future Roadmap and Features for Order Editing17:14Closing Thoughts and Personal Insights

In today's episode, McKay explores the idea of choosing to see the best in people and situations, presenting the argument that an individual's perspective is an active force that can shape outcomes. Using examples from politics, prisons, and creative studios, he explains how a decision to focus on potential rather than flaws can build connections and lead to unexpected results. To demonstrate this principle, McKay shares several stories about individuals who chose to see the best in others. He recounts the friendship between Nelson Mandela and his prison guard, Christo Brand, who saw each other's humanity within a system designed for division. He details how mentors who recognized hidden talent were instrumental for comedian Lucille Ball and high-jump innovator Richard Fosbury. The episode also covers how Abraham Lincoln turned a political opponent into an ally and how Kevin Costner's belief in a script helped get the film Field of Dreams made. Each account illustrates how one person's choice to see potential created an outcome that once seemed impossible.Main Themes:Seeing the best in others is a learnable skill that transforms your influence.Your perspective on people directly shapes how they react to you.Unlock greatness in others by focusing on their potential, not their flaws.Look past differences to forge powerful alliances and unlikely friendships.Find the hidden gift or lesson in every difficult circumstance.A positive outlook can turn a rejected idea into a celebrated masterpiece.Great leaders see the strength in rivals and turn them into allies.Encourage authenticity by helping others trust their unique instincts.Habitually seeing the best creates a positive ripple effect in your environment.Improve your life by asking, “What can this teach me?” instead of pretending everything is perfect.Top 10 Quotes:“The way you see people changes everything.”“If we chose to see the best in other people, there would be worlds that would open to us.”“There is a gift in every hardship; your job is to find it.”“Life just goes better when you see the best in things.”“When we see the best in others, in things, in circumstances, they change.”“He saw the goodness in Christo. And the best they saw in each other started to grow.”“If you'll see the potential, the best in others, you'll improve your influence as a person and coach.”“Lincoln had seen past his ego and competition to see the best in this man. And in doing so, won his loyalty and friendship for life.”“What if you tried, just for a short time, to only see the best in the people on your team?”“You just might change your future in the process.”Show Links:Open Your Eyes with McKay Christensen

Kevin McKay preaches "Seeking God's Smile" from Psalm 80, continuing our series "Psalms", in this Sunday morning gathering of Grace Harbor Church.

Ever felt like your culture change efforts are just… throwing spaghetti at the wall

It was fun to chat with another California photographer, Jeff Galinovsky, all about the business side of photography. He has been at it since 1988 (yep, with a Minolta Maxxum 7000!) and now runs a thriving business in high-volume sports, senior and family portraits, corporate branding, and events. He's a CPP, Master of Photography, President of the Professional Photographers of Sacramento Valley, and an instructor with McKay Photography Academy.His recent trip with McKay was to Mongolia, and you really want to see the amazing photos on his Facebook page!Jeff and I dig into what it really takes to go full-time in photography—spoiler: it's not about quitting on a whim. He shares how he prepared, got mentoring, leaned on professional organizations, and built a foundation that allowed him to succeed long-term.We also cover:Planning ahead and thinking big-picture for your businessMultiple streams of income vs. specializing (and why both can work)Business basics: legal setup, customer service, target market, marketing, and pricingWhy mentors, community, and continuous learning are game-changers If you want to grow a photography business that lasts for decades, this conversation will give you a roadmap.Find Jeff here:Website: jeffgalinovskyphotography.comEmail: jeff@jeffgalinovskyphotography.comLinkedIn: Jeff GalinovskyConnect with Photography Business Coach Luci Dumas: Website Email: luci@lucidumas.comInstagram FacebookYouTubeNew episodes drop every week — make sure to subscribe so you never miss an inspiring guest or a powerful solo episode designed to help you grow your photography business.

McKay delves into the liberating principle that success isn't bound by age or a rigid schedule in this latest instalment of the Open Your Eyes podcast. Throughout the episode, he drives home the point that, whether you're an early prodigy or a late bloomer, life's rewards go to those who have the courage to start, and to start again, no matter where they are on their journey.McKay brings this concept to life with the stories of a number of remarkable individuals, including the winding path of Marvel Comics creator Stan Lee, who found his true voice after 20 years in the business, and the story of Ray Kroc, who built the McDonald's empire in his fifties. He also delves into the lives of chef Julia Child, designer Vera Wang, and blind mountaineer Erik Weihenmayer, each of whom redefined their lives by starting something new long after others might have given up. These stories clearly demonstrate that the most important step is always the next one.Main Themes:It is never too early or too late to pursue your passion or reinvent yourself.Life rewards persistence, authenticity, and grit over perfect timing.Comparing your journey to others leads to paralysis and a false sense of being behind.Early success does not guarantee a simple path, just as a late start does not preclude greatness.Your past experiences, even the challenging ones, can provide the wisdom and depth needed for future success.The end of one chapter, like a job or a dream, is not the end of your story.Starting over is not a sign of failure; it is proof that you are still fighting for your future.Embrace the support of others, as encouragement is crucial when trying again.Your worth is not defined by a timeline, but by your courage to show up.The most powerful creative work often comes from pursuing what you truly believe in.Top 10 Quotes:"In the end, life doesn't care if you started early or late. It cares that you started and that you showed up.""Life is not a race, and you are not behind.""Your worth is not tied to how early or how clean your path has been.""Don't confuse loss with defeat. The end of one chapter doesn't mean the story's over, it just means the next one is ready to be written.""Starting over isn't failure, it's proof I'm still fighting.""Sometimes the most beautiful currents take longer to find.""Life rewards persistence, authenticity, and grit over perfect timing.""What matters is that you try again."Show Links:Open Your Eyes with McKay Christensen

Mahara McKay ist Tantralehrerin. Ihr Weg dorthin war ungewöhnlich: 2000 wurde sie Miss Schweiz, modelte und tourte als DJ um die Welt. Doch das Glitzerleben erfüllte sie nicht – sie ging auf Reisen und die Suche nach sich selbst. Die ersten 10 Jahre wuchs die Tochter einer Schweizerin und eines Maori in Neuseeland auf. Nach der Trennung der Eltern zog sie mit ihrer Mutter in die Schweiz, wo sie in der Schule Ausgrenzung und Mobbing erfuhr. Der Sieg bei der Miss-Schweiz-Wahl öffnete Türen in die Mode- und Musikszene. Doch der Glamour und Erfolg brachte nur bedingte Erfüllung. Auf der Suche nach sich selbst reiste sie nach Indien, wo sie Yoga und Tantra entdeckte. «Ich habe 33 Jahre falsch geatmet.» Heute hilft sie als Lehrerin anderen, innere Wunden zu heilen und mehr Selbstliebe und Ekstase zu leben. ____________________ Habt ihr Feedback, Fragen oder Wünsche? Wir freuen uns auf eure Nachrichten an focus@srf.ch – und wenn ihr euren Freund:innen und Kolleg:innen von uns erzählt. ____________________ «Focus» ist ein Podcast von SRF Host: Donat Hofer Angebotsverantwortung: Anita Richner ____________________ Das ist «Focus»: Ein Gast – eine Stunde. «Focus» ist der SRF-Talk, der Tiefe mit Leichtigkeit verbindet. Nirgends lernt man Persönlichkeiten besser kennen. ____________________ (01:33) Biografie (9:44) Weg zu sich (17:22) Schattenseiten kennen lernen (25.54) Was ist Tantra? (26.54) Sexuelle Traumata (37:35) Grenzen setzen (44:58) Vergebung nach Vergewaltigung ____________________ Diese Folge wurde zum ersten Mal am 03.03.2025 ausgestrahlt.

Kevin McKay preaches "Money" from Proverbs, in this Sunday morning gathering of Grace Harbor Church.

From shaky evacuation logistics to underused heroes, Jack Baruzzini, Jeff Haecker, and Victor Lams debate “Inferno's” big swings—McKay's volcanic gambit, Weir's tense negotiations, and the episode's behind-the-scenes quirks. The post Inferno (SGA) appeared first on StarQuest Media.

Listen to the full interview with Ben McKay. See omnystudio.com/listener for privacy information.

Ritchie McKay, Liberty Men's Basketball HC by Ed Lane

Spencer McKay, Victoria Vikes legend, BC Basketball Hall of Fame Member and SMNT Canada Basketball Alumni pulls up on Canada Hoops Podcast ! Spencer sits down with us to share his basketball story. Spence tells us about running club teams and camps back in the Oliver and Penticton area which keeps him giving back to the game. Spencer tells us about growing up in Oliver, British Columbia, where he started to play basketball. The game was a family affair and Spencer also did swimming which helped with his hoops game. Spencer talks about basketball in the province at that time, how strong the competition was and that fierce competition allowed Spencer to get noticed from Division 1 schools in the States. Spencer weighed his options but opted to stay at home and chose to play basketball for the University of Victoria under the legendary HC Ken Shields. Spence put together a truly remarkable career at UVIC and he speaks fondly of his time as a Vike. Spencer then takes his game pro and takes us through that transition and tells us about his pro journey which took him all over the world.And you know we dive into Spencers' time with Canada Basketball. Spence tells us about some of his favourite teams he played with for Canada Basketball, his outstanding teammates which included the likes of Steve Nash and Rick Fox and reflects on his many friendships and relationships from his time with Canada Basketball. And then Spencer drops his great Top 5 of all time for Canada Basketball on us. Much love to Spencer McKay for joining us on Canada Hoops !Hit us up on Twitter: @canadahoopspod @TheMattyIrelandHit us up on Instagram: @canadahoopspodcastEmail: canadahoopspodcast@gmail.comhttps://canadahoopspodcast.buzzsprout.com/https://www.youtube.com/@canadahoopspodcast

We did it…100 EPISODES of the Gutted Horror Podcast!! Join hosts Tony and Aleece for a killer celebration packed with horror movie memories, fan-favorite moments, listener shoutouts, and bone-chilling surprises.Whether you're a long-time listener or finding us for the first time, this is the perfect gateway into our horror-obsessed world. From slasher classics to cult favorites, found footage frights to so-bad-it's-good gems, we've spent 100 episodes SPILLING OUR GUTS about the movies we love!

What does it truly mean to commit? This week, McKay explores the powerful principle of "putting your stake in the ground," an unwavering declaration of your chosen path. Our host illustrates that avoiding the "murky middle" of indecision and making a firm, whole-hearted commitment is what separates fleeting attempts from life-altering success.Bringing this concept to life through a series of unforgettable stories, McKay shares powerful lessons from a harrowing whitewater kayaking trip and the historic Oklahoma Land Rush. He also explores the incredible resolve of cancer research activist Terry Fox, the ancient wisdom of Japan's Tsunami Stones, and the late-in-life triumphs of polar explorer Barbara Hillary. Each story demonstrates how to stake your claim on your future and build the life you are meant to live.Main Themes:Understanding the "why" behind a process empowers you to see it through.Making a firm, public commitment to a goal increases your chances of achieving it.Avoid the "murky middle" of indecision, which leads to paralysis and unhappiness.Success requires a whole-hearted effort, not a half-hearted attempt.Adopt a "no matter what" attitude when pursuing a difficult goal.Postpone judgment on your progress by deciding that "today is not voting day."Our past failures can give us the clarity to finally commit to our true path.Our commitment and example can serve as a guide for future generations.It is never too late to put your stake in the ground and achieve the extraordinary.True power is unlocked when you commit entirely and without reservation.Top 10 Quotes:"Understanding changes everything. It empowers you.""The people that reach their goals are most often those that have put their stake in the ground and said, 'I'll do this, no matter what.'""Today is not voting day. Today is working day. Voting day is later.""Half-hearted effort is without staying power.""He promised to complete his run, even if he had to crawl every last mile.""I stopped pretending I was anything other than what I was. And I determined, more than I had ever determined to do what I was meant to do: to write.""You'll find that a whole-hearted effort will result in success."Show Links:Open Your Eyes with McKay Christensen

Mark dives into the Prophet David O. Mckay as a father, and his teachings on parenthood. Despite David O. Mckay's busy life as a church leader, apostle, and prophet; he was an incredible parent and husband, and made those duties his greatest priority. Check out Marks Book- No Other Success: The Parenting Practices of David O. Mckay on Amazon, for a deeper look into the life of President Mckay.

Kevin McKay preaches "Not Losing Faith" from Psalm 79, continuing our series "Psalms", in this Sunday morning gathering of Grace Harbor Church.

McKay on Sport. He talks about Richie Mo’unga and the renaissance of free-to-air sport.See omnystudio.com/listener for privacy information.

Preaching for the Nineteenth Sunday in Ordinary Time, Meredith McKay offers a reflection on moving past fear and paralysis to take risks for the good of the world: "Fear keeps us still, while faithfulness keeps us growing. The world today needs people who acknowledge their fear and move past that tendency towards paralysis to instead do their best to live out the call of the gospels."Meredith McKay is Director of University Ministry at Gonzaga University in Spokane, Washington. She completed a Doctor of Ministry at Emory University's Candler School of Theology where she studied trauma and the implementation of trauma-informed care in college campus ministry. An avid reader and writer, she also spends her days experimenting in the kitchen, practicing yoga, connecting with friends, and hanging out with her dog, Junie B. Jones.Visit www.catholicwomenpreach.org/preaching/08102025 to learn more about Meredith, to read her preaching text, and for more preaching from Catholic women.

Dr. Sarah McKay is a neuroscientist, author, and science communicator passionate about making brain science accessible and practical. With a PhD in neuroscience, she specializes in exploring the female brain and its transformations across life stages. Her books, The Women's Brain Book and Baby Brain, delve into the neuroscience of health, hormones, and motherhood. She's also the director of The Neuroscience Academy, bridging the gap between cutting-edge research and everyday life. We talk about: - Dr McKay's passion for science communication - Her inspiration for writing her books - Understanding the brain and menopause - Advancements in menopause research - Challenges in menopause research and communication - The impact of menopause on cognition and mood - Menopause in the workplace - The need for reliable data and room for nuance - Lifestyle and menopause management - The need for humor in menopause - Future directions in menopause research  And lots more! If you want to understand what happens to our brains in midlife, this podcast is a must listen. If you enjoyed this episode, please subscribe, share it and leave us a 5* review on iTunes or wherever you're listening. Order the ebook or audiobook (narrated by Rachel) versions of Rachel's book, Magnificent Midlife: Transform Your Middle Years, Menopause And Beyond at magnificentmidlife.com/book The paperback can be purchased on Amazon or other online retailers: UK: https://www.amazon.co.uk/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ US & Canada: https://www.amazon.com/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ Australia: https://www.amazon.com.au/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ You can listen to all the other episodes and get the show notes at magnificentmidlife.com/podcast. Recommended by the Sunday Times. Feedspot #9 in 40 Best Midlife Podcasts and #7 in 60 Best Women Over 50 Podcasts You'll find lots of strategies, support, and resources to help make your midlife magnificent at magnificentmidlife.com. Check out Rachel's online Revitalize Experience, a 6-week intensive small group mentoring experience or 1-1 Midlife Mentoring.

The profound notion that each of us is born for a unique purpose comes under McKay's learned scrutiny in this week's episode of the Open Your Eyes podcast. Noting that true happiness isn't found in mere achievements, our host demonstrates that discovering and living this purpose, especially through serving others, is actually the key. The episode is filled with powerful and inspiring stories of individuals who turned immense challenges into their greatest strengths. From Kevin Briggs, the "Guardian of the Golden Gate Bridge," to one-legged NCAA wrestling champion Anthony Robles, and from Olympian Michael Phelps to autism advocate Dr. Temple Grandin, McKay breaks down how our past doesn't disqualify us but prepares us for our purpose. Listen in now to discover how to find your own reason for being and transform your perspective on life, challenges, and happiness.Main Themes:You were born for a purpose, and discovering it is the key to true happiness.Your past doesn't disqualify you from your purpose; it prepares you for it.Your unique differences can be your greatest strengths.Lasting change begins with changing the way you think, not just with willpower.True purpose is often found in using your story to help and serve others.You don't need perfect conditions to start living your purpose.Small acts of compassion can lead to world-changing innovations.Listen to the whisper that says, "Maybe I could do something."Challenges and mistakes can lead you to the very place you are meant to be.Happiness is found in the pursuit of purpose, not just the achievement of goals.Top 10 Quotes:"I don't think I was born with a disadvantage. I think I was born for a reason.""I realized my past didn't disqualify me from my purpose. It prepared me for it.""I think the world needs different kinds of minds to work together. My difference is my strength.""I found that winning gold medals wasn't my purpose. My purpose is helping people who struggle like I did.""Before I formed you in the womb, I knew you. Before you were born, I set you apart and gave you a purpose.""You are the way you are because you were born for a purpose.""The way you think determines the way you feel, and the way you feel influences the way you act.""We can't be what we can't see.""It's okay not to be okay."Show Links:Open Your Eyes with McKay Christensen

I have a confession to make: I use my GPS every time I drive. It's not that I don't know where I'm going. It's that I've told myself, “the GPS knows more than me – it has traffic data!” Nick Bennett pointed out on LinkedIn that there was a time before GPS, when people knew how to read a map…or just get around. And that was a present in today's guest's mind when he made a big decision. Joe McKay is a LinkedIn Ghostwriter who used AI for everything…until the day he decided he'd go AI Vegan. Today we're going to talk about what it meant for his business and his mind, and if you should try it too. Want to go AI Vegan but worried you'll be even less productive? Take the Business Systems Diagnostic and let's see how we can fix your systems! Top Takeaways:Joe found that, after a while, he was more concerned with whether or not people could tell if his writing was AI-generated, and less about what his customers…and their audience…actually needed. AI gives us the ability to do more, faster. But you're making a choice – a bunch of prefab, low-quality stuff, or high-quality, hand-crafted work. But Joe and I have deeply considered what we're losing by outsourcing to AI. Much like exercise, you need to actually do the knowledge work for you to stay sharp. Is AI dulling the skills we've staked our business on?Show Notes:Joe McKay on LinkedInJoe's Beehiiv Nick's GPS post on LinkedInAm I Outsourcing My Brain to AI? [Audio Note]I want to hear from you! Send your feedback to https://streamlinedfeedback.com. *While I usually use AI to help me write the descriptions and takeaways, this time around, I decided to go AI Vegan, out of respect for Joe!  ★ Support this podcast ★

Kevin McKay preaches "Friendship", in this Sunday morning gathering of Grace Harbor Church.

Father Doug McKay joins TJ to talk about sobriety and the venerable Matt Talbot becoming the patron saint of alcoholics Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us a textWhat if you could understand the science behind why your teenager seems impossible, why habits are so hard to break, or why menopause affects your thinking? Dr. Sarah Mackay, an Oxford-trained neuroscientist and founder of the Neuroscience Academy, joins us to demystify the complex world of the brain with warmth, wit, and scientific precision.This conversation upends common misconceptions about brain development while offering practical insights for everyday life. Dr. Mackay takes us on a journey through neuroplasticity—the brain's remarkable ability to change throughout life—explaining how this process underpins everything from habit formation to teenage rebellion. She shares evidence-based strategies for behavior change that work with your brain's natural tendencies rather than against them, like "habit stacking" to make new behaviors stick.We explore fascinating research on sex differences in the brain, revealing how both biology and social factors shape cognitive development across cultures. Dr. Mackay offers a refreshingly balanced perspective on "brain fog" during menopause, acknowledging the complex interplay between hormones, sleep, stress, and societal expectations. Perhaps most valuably, she emphasizes the profound importance of social connection for cognitive health, suggesting that meaningful relationships might matter more than trendy biohacks or optimization techniques.Throughout our discussion, Dr. Mackay's compassionate approach to aging and body image resonates deeply. Her insight that "there are no mirrors in nature" provides a powerful reframing of how we view ourselves as we age. Whether you're navigating parenthood, midlife transitions, or simply curious about how your mind works, this episode offers both scientific substance and genuine wisdom about embracing the brain's natural evolution through all life stages.Dr. Sarah McKay links:IG: @drsarahmckayX: @drsarahmmckaywebsite: https://drsarahmckay.comTweet me @realdrhamrahIG @drhamrah

This week, McKay delves into the essential principles of effective coaching, asserting that we all take on this vital role in our lives, whether as parents, leaders, or mentors. The episode is packed with practical lessons designed to help you elevate your own coaching skills and empower those around you.Exploring the high-stakes worlds of professional sports, McKay analyzes iconic moments in coaching history. From the controversial 2018 US Open final between Serena Williams and Naomi Osaka to the legendary leadership of Pat Summitt, Lou Holtz, and “Miracle on Ice” coach Herb Brooks, this episode breaks down what makes a coach truly great. Join our host here today to learn the art of great coaching and discover how to build belief, instill confidence, and elevate both your team and yourself to achieve your highest potential.Main Themes:Coach who people can be, not just who they are.Become a “first-class noticer” of hidden potential.Simplify to empower; complexity paralyzes.Center your team on their core identity, especially amid chaos.Keep your team in the “progress zone,” not the comfort zone.Help others flip the script on their limiting stories.Confidence is a result of action, not a prerequisite for it.Effective coaching isn't always about being liked.Use powerful, simple questions to unlock answers.Recognize that everyone is a coach in some capacity.Top 10 Quotes:“Great coaches don't coach who people are; they coach who they can be.”“She didn't see just who I was; she saw who I could be, and she never let me settle for less.”“Mental anticipation now pulls the future into the present and reverses the direction of causality.”“You don't have to make history today. You just have to play like you belong in it.”“You were born to be hockey players. You were meant to be here, and this moment is yours.”“The greatest obstacle you will face in your life is in your own mind.”“Dreams are cheap.... That's where they will stay unless you leave your comfort zone.”“Confidence is always developed by action.”“I'm not looking for the best players; I'm looking for the right players.”“What are you doing now, what is it costing you, and what do you want instead?”Show Links:Open Your Eyes with McKay Christensen

If you've ever unrolled a B Mat in class, or have been on the hunt for the grippiest yoga mat out there, this one's for you.Today we're joined by Andrea McKay, founder and CEO of b, halfmoon, and the force behind one of the yoga world's most beloved props: the B Mat. She shares how the brand was born, her business background and inspiration, and how a little bit of naivety and a lot of passion helped her get her start.We talk about the evolution of the company, from logo changes to the acquisition of Halfmoon, and the deeper meaning behind the brand's signature comma. Giana fan-girls over a hard-to-find mat (that Andrea jokingly promises her) and pitches a custom “G Mat,” because we all need one of those.There's plenty of laughter, a few trade secrets (yes, we talk stickiness), and real talk about returning to your roots and the power of simplicity. Andrea opens up about the company's major production pause, the challenges that led to it, what it taught her, and how the support of the community brought them back stronger.We also dive into uncertainty, resilience, throwing things into the fire, grounding practices, feeling like a hypocrite in this work, and the importance of staying connected to your purpose. And yes, we reference Bradshaw's viral sticky mat reel that has the yoga world giggling, because everyone has an opinion.Press play and join us for an episode full of heart, hustle, and sticky mats. Plus, use code FUNNYTHING20 for 20% off anything from B, Half Moon.B, Halfmoon Website: www.bhalfmoon.comIG handles: @bhalfmoon_official + @beingandreamckay

GFA 466. Discover how AI avatars are revolutionizing the Amazon FBA and e-commerce space in this episode of Global From Asia. Host Michael Michelini interviews Katrina McKay, the virtual brand ambassador for New York Bar Store, as she shares how she uses AI tools for viral video content, customer engagement, and growing a digital brand. Bonus: Meet GFA's new community manager and get a preview of Cross Border Summit 2025! The post Using AI Avatars for Your E-commerce and Amazon FBA Business with Katrina Mckay appeared first on Global From Asia.

For full show notes go to https://www.globalfromasia.com/ai-avatar/ The post GFATV 466 Using AI Avatars for Your E-commerce and Amazon FBA Business with Katrina Mckay appeared first on Global From Asia.

McKay explores how our most difficult experiences and perceived flaws can become our greatest strengths in this week's thought provoking instalment. Throughout the episode, he challenges us to reframe our past, not as a source of shame, but as the very foundation of who we are today.Drawing upon the powerful and moving life stories of actress Viola Davis, Starbucks founder Howard Schultz, and others, McKay illustrates how adversity can be the unlikely source of our greatest achievements. He delves deeply into how childhood trauma, failure, and hardship, rather than breaking them, provided the unique perspective, empathy, and resilience necessary for their success. Tune in today and accept our host's sincere invitation to view your own struggles not as liabilities, but as the very experiences that can forge character and lead to a remarkable future.Main Themes:Past pain can shape you, not just define you.Owning your full story is the key to self-love.Adversity builds resilience, empathy, and strength.Reframe your story from "ruined me" to "shaped me."Self-forgiveness is a powerful act of release.Hardships can be a launchpad to your purpose.Imperfections can help you go farther, not hold you back.Success is not a straight line; it's forged in struggle.Find meaning in suffering to transform it.Become the author of your own story.Top 10 Quotes:"To love who you are, you must not hate the experiences that shaped you.""I'm not what happened to me. I am what I choose to become.""Deny your story, it defines you. Own it, and you write the ending.""Every painful memory...served as a leap pad that has shaped me.""When we're no longer able to change a situation, we're challenged to change ourselves.""It's the hard things that give us the strength we need later in life.""Our paths are rarely straight; great things happen amid struggles.""The worst thing that happened to her gave her the ability to do the best thing.""When you fall off life's ship, there is a line waiting to be grabbed.""The goal is not to be someone in spite of what happened, but someone because of it."Show Links:Open Your Eyes with McKay Christensen

Another CEO memo on AI is making waves - this time from Amazon's Andy Jassy, who outlines the tech giant's aggressive AI strategy and hints at workforce reductions. While some may see it as ominous, others view it as a rallying cry for change. The AI Knowhow team dives deep into what this latest corporate proclamation really means. First, NordLight CEO Pete Buer and Knownwell CMO Courtney Baker unpack Jassy's memo, especially its stark honesty about AI's impact on jobs—and what it means for your own upskilling strategy. Then Courtney is joined by Knownwell's CEO David DeWolf and Chief Product and Technology Officer Mohan Rao to unpack how leaders at all levels—not just the C-suite—can take initiative, align teams, and prove they're a few steps ahead before the next memo lands. From strategic intent to narrative discipline and modular operating systems, they break down the practical moves that position you to lead with action, not just reaction. Also, Pete Buer chats with Jeff McKay, founder of Prudent Pedal, to explore how AI is transforming organizational structures in professional services firms. They examine McKay's “IC Triad” model and how marketing, sales, and delivery must evolve to remain competitive in the AI era. Check out the Knownwell platform to see how your own company's data can unlock next-level decision-making at www.knownwell.com.  Watch this episode on YouTube: https://youtu.be/inqzp0KmoWg 

**I put the concluding 20 mins of the conversation behind the paywall on audio. If you want to listen to the entire episode, sign up for Patreon for less than $2 a month or watch it on our YouTube channel (linked below)** **Note: I managed-yet again-to mess up my audio settings at the last minute before we started recording resulting in me sounding blown out. Apologies!** Returning guest Alexander Mckay and Kit Klarenberg, co-hosts of the Decline and Fall, discuss the deepening crisis Western imperialism faces as it wages proxy wars against Iran and Russia simultaneously and economic war against China. Watch the video edition on The East is a Podcast YouTube channel Consider supporting the show www.patreon.com/east_podcast

This week, McKay introduces a practical and powerful challenge: the one-month happiness test. Drawing inspiration from Laurie Santos's famous Yale course, "Psychology and the Good Life," this episode moves beyond big, life-altering events to focus on the small, consistent actions that are scientifically proven to boost happiness. McKay breaks down simple yet profound practices like savoring positive moments, actively choosing your focus through selective attention, expressing gratitude, performing acts of kindness, and strengthening social connections. Through relatable stories and real-world examples, he illustrates how these "micro-adjustments" can retrain our brains, counteracting our natural negativity bias and leading to a more joyful, fulfilling life. Listeners are invited to take the test for themselves and discover how intentional, daily habits can create lasting change.Main Themes:Happiness comes from small, consistent changes, not just big life events.You can retrain your brain to focus on the positive through selective attention.Savoring positive experiences - before, during, and after - deepens their impact.Practicing gratitude is a powerful choice that turns what you have into enough.Acts of kindness boost happiness for both the giver and the receiver.Strong social connections are a primary predictor of a long, happy life.Exercise and sleep are foundational pillars for mental well-being and happiness.You can become the author of your life by choosing what to focus on and practice.What you notice becomes your reality.A one-month test is long enough to implement new habits and see real results.Top 10 Quotes:"The strange truth is... most people return to their baseline level of happiness after these major life events. This phenomenon is called the hedonic treadmill.""Tiny, regular changes to your daily life often make a bigger, longer-lasting difference than these big things.""Your brain is built to scan for problems... but you can change what you focus on, and it will help you be more happy.""Savoring is the deliberate, post-activity act of looking back on what you've done and taking time to appreciate it.""Gratitude turns what we have into enough.""Close relationships, more than money or fame, are what kept people happy throughout their lives.""These examples aren't miracles; they're micro-adjustments in their lives.""You get to choose what you'll focus on. So this month, to test your happiness, focus on the good.""Kind service has this magic feel to it."Show Links:Open Your Eyes with McKay Christensen

I'm not currently active on LinkedIn but ironically, if I was starting a web design business today, it's the place I'd spend most of my social media/online connection time.Why? Well, mainly because I know it's geared towards connecting professionals rather than social media algorithm entertainment. If you're interested in what's working well for getting clients on LinkedIn today, my chat with LinkedIn expert Joe McKay is a great guide to follow.Joe knows the platform, knows the ins and outs and how to practically set yourself up for success rather than burnout if you're going to commit to making LinkedIn a large part of your social strategy.Head to the show notes to get all links and resources we mentioned along with a full transcription of this episode at joshhall.co/386

McKay shares a collection of powerful, real-world stories here today as he explores the transformative power of viewing life as a journey from one form of strength to another. From a collegiate runner's recovery after a devastating accident to the historic leadership of Abraham Lincoln and the creative genius of Beethoven, our host illustrates how our greatest weaknesses can become the catalysts for our most profound strengths.Listeners will learn to reframe challenges, setbacks, and even failures not as endpoints but as essential experiences that build resilience, empathy, and new capabilities. McKay offers practical advice on the importance of trying, seeking help, and taking small, consistent steps to move forward. Today's episode is a compelling reminder that who we are is not static; we are constantly developing, and our struggles are an integral part of that growth.Main Themes:Life is a continuous journey of moving from one developed strength to another.Weaknesses and challenges are opportunities to build new, deeper strengths.Overcoming adversity fosters resilience, empathy, and maturity.The simple act of trying, especially after failure, is a powerful catalyst for growth.Seeking help is a sign of strength, not a weakness.You can begin to change your life by doing something different today.Growth requires taking risks and stepping outside your comfort zone.Focus on doing a little more of what works and a little less of what doesn't.Top 10 Quotes:"The journey we take in this life is moving really from strength to strength.""The strength you gain in getting help and overcoming weaknesses propels you to the next level in your life.""Weaknesses that are given to us in life can help us move from strength to strength.""For when I am weak, then I am strong.""Each time you try, despite the lack of strength of the bridge or the chasm or the gaps in your life, you strengthen those bridges.""You don't have to let your past dictate your future, even if it's your recent past.""You may not have to have all the answers. Just do a little bit more of what works and a little bit less of what doesn't.""It's when we step outside our normal routine or normal circumstances that we see and grow in new ways.""Starting where you are is sometimes all you can and often all you need to do. Trying is enough.""Your talents rise and your gaps are spanned, and your weaknesses become strengths."Show Links:Open Your Eyes with McKay Christensen

This episode will change how you understand your brain – and yourself. If you've ever felt like your brain is working against you – think brain fog, mood swings, and exhaustion – you're not crazy, you're not broken, and it's not your fault. Today, world-renowned neuroscientist Dr. Sarah McKay joins Mel for a groundbreaking conversation that will completely transform how you understand your brain. Dr. McKay has spent 30 years studying the brain. She holds a Doctorate in neuroscience from Oxford University and flew over 10,000 miles from Australia to sit down with Mel for this conversation. In this episode, she reveals the 3 factors that influence how your brain develops. She also  tells you how you can use that information to reset your brain for a better mood, more energy, and greater mental clarity. Whether you're a woman looking for answers about why your brain is freaking out during PMS, or you are forgetting things during pregnancy or menopause, this is a must listen. In this episode, you'll learn: -The 3 forces that shape your brain before you're even born and how they differ if you are male or female -What's actually happening in your brain during PMS, pregnancy, and menopause and why it's not what you think -What men need to know about the female brain and what it reveals about their own -The long-term impact of telling a young girl she's “not a math person” -Why your brain shrinks during pregnancy and how that helps your baby -The real role of hormones in memory, mood, and mental health What you'll learn today will give you a deeper, research-backed understanding of how the brain really works, and how powerful it truly is. This isn't about fixing your brain. It's about understanding it and learning how to work with it. For more resources, click here for the podcast episode page. If you liked the episode, check out this one next: The Body Reset: How Women Should Eat & Exercise for Health, Fat Loss, & EnergyConnect with Mel:  Get Mel's #1 bestselling book, The Let Them TheoryWatch the episodes on YouTubeFollow Mel on Instagram The Mel Robbins Podcast InstagramMel's TikTok Sign up for Mel's personal letter Subscribe to SiriusXM Podcasts+ to listen to new episodes ad-freeDisclaimer

Sean and Amanda return to continue their yearlong project of listing the 25 best movies of the 21st century so far. Today, they discuss Adam McKay's ‘Anchorman: The Legend of Ron Burgundy' starring Will Ferrell, one of the most iconic comedies of all time. They highlight the wildly successful partnership of McKay and Judd Apatow, why they made the painfully difficult decision to choose this as their official studio comedy selection over ‘Superbad', and celebrate Christina Applegate's wonderful performance. Hosts: Sean Fennessey and Amanda Dobbins Producer: Jack Sanders Learn more about your ad choices. Visit podcastchoices.com/adchoices