Podcasts about systems biology isb

Send us a textDr. Sui Huang, MD, PhD is a Professor at the Institute for Systems Biology ( ISB - https://isbscience.org/people/sui-huang-md-phd/?tab=biography ) where his lab is focused on studying how gene regulatory networks control gene activity to create stable cellular states, such as different cell types, and how these states transition into different lineages in both healthy and diseased conditions.Dr. Huang is a molecular and cell biologist with a strong background in theoretical biology and has devoted much of his research to understanding the very phenomenon of cancer from a complex systems perspective. Before joining the ISB in fall 2011, Dr. Huang held faculty positions at the University of Calgary (Institute of Biocomplexity and Informatics), where he helped establish biocomplexity as a discipline in research and teaching, and at Harvard Medical School (Children's Hospital) where he obtained first experimental evidence for the existence of high-dimensional attractors in mammalian gene regulatory networks.Dr. Huang grew up in Geneva and Zurich. He received his MD degree from the University of Zurich and obtained thereafter, as the first recipient of the PhD-Program-for-Physicians Award of the Swiss National Science Foundation, his PhD in molecular biology and physical chemistry for work on interferons. As a postdoctoral fellow at Children's Hospital Boston he investigated tumor angiogenesis and cell growth control. In that period he also studied dynamical systems through his affiliation with the New England Complex Systems Institute.Important Episode Link - "The end of the genetic paradigm of cancer" - PLOS Biologyhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003052#SuiHuang #InstituteForSystemsBiology #Interferon #Angiogenesis #AttractorStates #Epigenetics #Cancer #Oncology #TumorMicroenvironment #DonaldIngber #ConradWaddington #Organogenesis #Morphogenesis #LeeHood #BeatriceMintz #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show

Send us a textDr. Sean Gibbons, Ph.D. is Associate Professor at the Institute for Systems Biology ( ISB - https://isbscience.org/people/sean-gibbons-phd/?tab=biography ) where his lab investigates how the structure and composition of evolving ecological networks of microorganisms change across environmental gradients, with a specific focus on how ecological communities in the gut change and adapt to individual people over their lifespans (i.e. host genotype, host development and host behavior) and how these changes impact human health ( https://gibbons.isbscience.org/ ). His lab develops computational and experimental tools for investigating host-associated microbial communities to explore the interactions between ecology, evolution and ecosystem function, applying these insights to develop personalized interventions for improving human health and well-being.Dr. Gibbons received his PhD in biophysical sciences from the University of Chicago in 2015, dual-advised by Jack Gilbert and Maureen Coleman. His graduate work focused on using microbial communities as empirical models for testing ecological theory. Dr. Gibbons completed his postdoctoral training in Eric Alm's laboratory in the Department of Biological Engineering at MIT from 2015-2018. His postdoctoral work focused on developing techniques to quantify individual-specific eco-evolutionary dynamics within the human gut microbiome.Dr. Gibbons was awarded a Fulbright Graduate Fellowship to study microbiology and synthetic biology at Uppsala University in Sweden, where he earned a master's degree in 2010. His PhD work was supported by an EPA STAR Graduate Fellowship. Upon joining the ISB faculty in 2018, his startup package was supported, in part, by a Washington Research Foundation Distinguished Investigator Award.Important Episode Link - Metagenomic estimation of dietary intake from human stool - Nature Metabolism - https://www.nature.com/articles/s42255-025-01220-1#SeanGibbons #InstituteForSystemsBiology #ISB #Microbiome #Microbes #Ecology #Medicine #Dysbioses #EcologicalTherapeutics #Virome #PrecisionNutrition #GutDigitalTwin #FecalMicrobiotaTransplantation #Longevity #Aging #Healthspan  #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Note: This episode originally aired in January 2023.   Tune in this week as special guest, Dr. Leroy Hood, an accomplished scientist best known for his integral work on the Human Genome Project, discusses data-driven analysis of chronic diseases and how our genomes may be able to provide individualized health recommendations in the future. During this episode you'll learn about:   1. Dr. Leroy “Lee” Hood, MD, PhD, a world-renowned scientist in human genomics, cancer research, Alzheimer's research, co-founder of the Institute of Systems Biology (ISB), and whose research allowed for the completion of the Human Genome Project [0:50]  2. Dr. Hood's personal life and early scientific background [1:27]  3. Dr. Hood's famous Caltech professors and what they taught him [7:03]  4. The systems biology approach of applying data taken over time to the body's networks [9:33]  5. Using a digital twin system to forecast Alzheimer's disease and make recommendations [13:25]  6. How blood samples taken years before a disease diagnosis present an opportunity [16:44]  7. What's the future of DNA sequencing for disease susceptibility? [19:31]  8. Questions from the community [24:02]  How did the Human Genome Project change the everyday person's life? [24:09] Is cancer becoming more common, or are we getting better at detecting it? [27:49] Could the CRISPR technique/ genome engineering help extend the human lifespan? [31:49]  Resources to topics mentioned in this episode:   Learn more about Dr. Hood's work at the Institute for Systems Biology (ISB)  The Age of Scientific Wellness – How to Reshape the Future of Personalized Medicine with Data and Artificial Intelligence  The AI Revolution in Personalized Health Care, with Nathan Price, Chief Scientific Officer  Three Science-Backed Lifestyle Changes to Lower Your Dementia Risk  How Chronic Inflammation Contributes to Disease and What You Can Do About It  Mayo Clinic: Exploring the Connections Between the Microbiome, Health, and Disease  How Plant Based Foods Help Fight Cancer  Eight Nutrients for Brain Health  Our Newest Health Panels – Advanced and Essential Data from a Basic Blood Draw  What Can a Microbiome Test Tell You That a Genetic Test Can't?  Will Exercise Extend Your Lifespan?  From the podcast archives: How to Solve an Age-Old Problem, with Dr. Lee Hood, Using AI to Advance Scientific Wellness    Products mentioned in this episode: Advanced Health Panel, Biological Age Health Panel, Essential Health Panel  Subscribe To More Content   Subscribe to the show wherever you listen to podcasts so you never miss an episode. You can also learn more about the topics in the episode by checking out the latest news, videos, and stories on Thorne's Take 5 Daily blog.  * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 

Taking us to the cutting edge of the new frontier of medicine, a visionary biotechnologist and a pathbreaking researcher show how we can optimize our health in ways that were previously unimaginable. We are on the cusp of a major transformation in healthcare—yet few people know it. At top hospitals and a few innovative health-tech startups, scientists are working closely with patients to dramatically extend their “healthspan”—the number of healthy years before disease sets in. In The Age of Scientific Wellness, two visionary leaders of this revolution in health take us on a thrilling journey to this new frontier of medicine. Today, most doctors wait for clinical symptoms to appear before they act, and the ten most commonly prescribed medications confer little or no benefit to most people taking them. Leroy Hood and Nathan Price argue that we must move beyond this reactive, hit-or-miss approach to usher in real precision health—a form of highly personalized care they call “scientific wellness.” Using information gleaned from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. Current applications have shown startling results: diabetes reversed, cancers eliminated, Alzheimer's avoided, and autoimmune conditions kept at bay. This is not a future fantasy: it is already happening, but only for a few patients and at a high cost. It's time to make this gold standard of care more widely available. Inspiring in its possibilities, and radical in its conclusions, The Age of Scientific Wellness shares actionable insights to help you chart a course to a longer, healthier, and more fulfilling life. Dr. Leroy Hood is a world-renowned scientist and recipient of the National Medal of Science in 2011. Dr. Hood co-founded the Institute for Systems Biology (ISB) in 2000, served as its first President from 2000-2017 and is a Professor and Chief Strategy Officer. In 2022, Dr. Hood started Phenome Health, a non-profit dedicated to delivering value through health innovation. Dr. Nathan Price is CEO of Onegevity, a division of Thorne HealthTech. He is also an (on leave) Professor at the Institute for Systems Biology, where he and Lee Hood co-direct the Hood-Price Lab for Systems Biomedicine. Additionally, Dr. Price is an affiliate faculty at the University of Washington in the Departments of Bioengineering, Computer Science & Engineering, and Molecular & Cellular Biology. In 2019, he was selected by the National Academy of Medicine as one of their 10 Emerging Leaders in Health and Medicine. Dr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly, he directed the National Cancer Institute-funded NSB Cancer Center, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017. Presented by Town Hall Seattle and the Institute of Systems Biology. The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands Third Place Books

My guest today is Leroy Hood, a world-renowned scientist and recipient of the National Medal of Science in 2011. He co-founded the Institute for Systems Biology (ISB) in 2000, served as its first President from 2000-2017, and is a Professor and Chief Strategy Officer. Dr. Hood was a faculty member at Caltech, serving for 10 years as the Chair of Biology. During this period, he and his colleagues developed four sequencer and synthesizer instruments that paved the way for the Human Genome Project's successful mapping and understanding of the human genome. He and his students also deciphered many of the complex mechanisms of antibody diversification. In 1992, Dr. Hood founded and chaired the Department of Molecular Biotechnology at the University of Washington, the first academic department devoted to cross-disciplinary biology. The topic is his book The Age of Scientific Wellness. In this episode of Trend Following Radio we discuss: Health care opportunities Phenotypic traits
 Three components of health trajectory
 Genome discussion Obesity
 Jump in! --- I'm MICHAEL COVEL, the host of TREND FOLLOWING RADIO, and I'm proud to have delivered 10+ million podcast listens since 2012. Investments, economics, psychology, politics, decision-making, human behavior, entrepreneurship and trend following are all passionately explored and debated on my show. To start? I'd like to give you a great piece of advice you can use in your life and trading journey… cut your losses! You will find much more about that philosophy here: https://www.trendfollowing.com/trend/ You can watch a free video here: https://www.trendfollowing.com/video/ Can't get enough of this episode? You can choose from my thousand plus episodes here: https://www.trendfollowing.com/podcast My social media platforms: Twitter: @covel Facebook: @trendfollowing LinkedIn: @covel Instagram: @mikecovel Hope you enjoy my never-ending podcast conversation!

My guest today is Leroy Hood, a world-renowned scientist and recipient of the National Medal of Science in 2011. He co-founded the Institute for Systems Biology (ISB) in 2000, served as its first President from 2000-2017, and is a Professor and Chief Strategy Officer. Dr. Hood was a faculty member at Caltech, serving for 10 years as the Chair of Biology. During this period, he and his colleagues developed four sequencer and synthesizer instruments that paved the way for the Human Genome Project's successful mapping and understanding of the human genome. He and his students also deciphered many of the complex mechanisms of antibody diversification. In 1992, Dr. Hood founded and chaired the Department of Molecular Biotechnology at the University of Washington, the first academic department devoted to cross-disciplinary biology. The topic is his book The Age of Scientific Wellness. In this episode of Trend Following Radio we discuss: Health care opportunities Phenotypic traits
 Three components of health trajectory
 Genome discussion Obesity
 Jump in! --- I'm MICHAEL COVEL, the host of TREND FOLLOWING RADIO, and I'm proud to have delivered 10+ million podcast listens since 2012. Investments, economics, psychology, politics, decision-making, human behavior, entrepreneurship and trend following are all passionately explored and debated on my show. To start? I'd like to give you a great piece of advice you can use in your life and trading journey… cut your losses! You will find much more about that philosophy here: https://www.trendfollowing.com/trend/ You can watch a free video here: https://www.trendfollowing.com/video/ Can't get enough of this episode? You can choose from my thousand plus episodes here: https://www.trendfollowing.com/podcast My social media platforms: Twitter: @covel Facebook: @trendfollowing LinkedIn: @covel Instagram: @mikecovel Hope you enjoy my never-ending podcast conversation!

Dr. Leroy Hood, MD, Ph.D. ( https://isbscience.org/bio/leroy-hood/ ) is Co-Founder, Chief Strategy Officer and Professor, at the Institute of Systems Biology (ISB) in Seattle, as well as CEO of Phenome Health ( https://phenomehealth.org/ ), a nonprofit organization dedicated to delivering value through health innovation focused on his P4 model of health (Predictive, Preventive, Personalized and Participatory) where a patient's unique individuality is acknowledged, respected, and leveraged for the benefit of everyone. Dr. Hood, who is a world-renowned scientist and recipient of the National Medal of Science in 2011, co-founded the Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. In 2016, ISB affiliated with Providence St. Joseph Health (PSJH) and Dr. Hood became PSJH's Senior Vice President and Chief Science Officer. Dr. Hood is a member of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. Of the more than 6,000 scientists worldwide who belong to one or more of these academies, Dr. Hood is one of only 20 people elected to all three. Dr. Hood received his MD from Johns Hopkins University School of Medicine and his PhD in biochemistry from Caltech. Dr. Hood was a faculty member at Caltech from 1967-1992, serving for 10 years as the Chair of Biology. During this period, he and his colleagues developed four sequencer and synthesizer instruments that paved the way for the Human Genome Project's successful mapping and understanding of the human genome. He and his students also deciphered many of the complex mechanisms of antibody diversification. In 1992, Dr. Hood founded and chaired the Department of Molecular Biotechnology at the University of Washington, the first academic department devoted to cross-disciplinary biology. Dr. Hood has co-founded 17 biotech companies including Amgen, Applied Biosystems, Rosetta and Arivale. His many national and international awards include the Lasker Prize, the Kyoto Prize, and the National Medal of Science. Dr. Hood's new book "The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands" is available on all major book sellers. Support the show

A world-renowned scientist and recipient of the National Medal of Science in 2011, Dr. Leroy Hood co-founded the Institute for Systems Biology (ISB) in 2000, served as its first President from 2000-2017 and is a Professor and Chief Strategy Officer. In 2016, ISB affiliated with Providence where Dr. Hood now serves as Emeritus Science Advisor. […]

Tune in this week as special guest, Dr. Leroy Hood, an accomplished scientist best known for his integral work on the Human Genome Project, discusses data-driven analysis of chronic diseases and how our genomes may be able to provide individualized health recommendations in the future. During this episode you'll learn about: Leroy Hood, MD, PhD, a world-renowned scientist in human genomics, cancer research, Alzheimer's research, co-founder of the Institute of Systems Biology (ISB), and whose research allowed for the completion of the Human Genome Project [00:00:50] Hood's personal life/ early scientific background [1:27] Hood's famous Caltech professors and what they taught him [7:03] The systems biology approach of applying data taken over time to the body's networks [9:33] Using a digital twin system to forecast Alzheimer's disease and make recommendations [13:25] How blood samples taken years before a disease diagnosis present an opportunity [16:44] What's the future of DNA sequencing for disease susceptibility? [19:31] Questions from the community [24:02] How did the Human Genome Project change the everyday person's life? [24:09] Is cancer becoming more common, or are we getting better at detecting it? [27:49] Could the CRISPR technique/ genome engineering help extend the human lifespan? [31:49] Resources to topics mentioned in this episode: Three Science-Backed Lifestyle Changes to Lower Your Dementia Risk How Chronic Inflammation Contributes to Disease and What You Can Do About It Mayo Clinic: Exploring the Connections Between the Microbiome, Health, and Disease How Plant Based Foods Help Fight Cancer Eight Nutrients for Brain Health Our Newest Health Panels – Advanced and Essential Data from a Basic Blood Draw What Can a Microbiome Test Tell You That a Genetic Test Can't? Will Exercise Extend Your Lifespan? Links to products mentioned in this episode:   Subscribe To More Content Make sure to never miss an episode by subscribing to the show on your podcast app. You can also learn more about what we talked about by visiting Thorne.com and checking out the latest news, videos, and stories on Thorne's Take 5 Daily blog. * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.   No products mentioned. Focus was on chronic diseases/ genetics, so I figured linking tests would be less suggestive than products.

Methuselah lived to 969 years old, according to the Bible. In our recent age, Jeanne Calmet holds the title of the oldest person who ever lived. She lived to be 122 years and 164 days old. There's a woman in Japan, Kane Tanaka, who is currently 118. Jiroemon Kimuri, also from Japan, is the oldest man of all time, living to 116 years and 54 days. How did they do it? How do some people avoid the deterioration and weakness that plagues many of their peers decades early? Is it luck, or something else? Is it possible to grow older without getting sicker? Could a 90-year-old not look a day over 50? In Age Later, Dr. Nir Barzilai, a pioneer in aging research, looked both at the four age-related diseases that take most of us (diabetes, cancer, heart disease, and Alzheimer's) and at SuperAgers (people who have maintained active lives well into their 90s who've never experienced any of those diseases). What can we learn from these subjects, who have not only reached a ripe old age but have further ripened the older they get? Dr. Barzilai revealed the secrets of these SuperAgers and the scientific discoveries so that we can mimic some of their natural resistance to the aging process. This isn't to say we'll live to 969, but there's still plenty of life yet to live for all of us. Dr. Nir Barzilai is the founding Director of the Institute for Aging Research at Albert Einstein College of Medicine, and is Director of the Nathan Shock Center for Excellence in the Basic Biology of Aging and the Einstein Glenn Center for the Biology of Human Aging. He is also the Scientific Director of the American Federation for Aging Research (AFAR). Lee Hood, MD, PhD is a world-renowned scientist who co-founded Seattle's Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. When ISB affiliated with Providence in 2016, Dr. Hood became Providence's Senior Vice President and Chief Science Officer. He is also Chief Strategy Officer and Professor at ISB. Buy the Book: Age Later: Health Span, Life Span, and the New Science of Longevity (Hardcover) Third Place Books  Presented by Town Hall Seattle and Institute for Systems Biology. 

Leroy (Lee) Hood is a world-renowned scientist and recipient of the National Medal of Science in 2011 from President Barack Obama. Dr. Leroy Hood co-founded the Institute for Systems Biology (ISB) and currently serves as the Chief Strategy Officer and Professor at ISB. He is a member of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. Of the more than 6,000 scientists worldwide who belong to one or more of these academies, Dr. Hood is one of only 20 people elected to all three. He has received 18 honorary degrees from prestigious universities in the U.S. and abroad and has published more than 850 peer-reviewed articles and currently holds 36 patents. Dr.Hood and his colleagues developed the instruments that paved the way for the Human Genome Project's successful mapping and understanding of the human genome. He and his students also deciphered many of the complex mechanisms of antibody diversification. Lee Hood is currently carrying out studies in Alzheimer's Disease, cancer, and wellness. He is pioneering a 1 million patient genome/phenome project for Providence and is bringing scientific (quantitative) wellness to the contemporary U.S. health care system. Dr. Hood has played a role in founding 15 biotechnology companies including Amgen, Applied Biosystems, Arivale, and Nanostring. He has co-authored textbooks in biochemistry, immunology, molecular biology, genetics, and systems biology. Leroy Hood Book Recommendations: The End of Average - Todd Rose Lifespan - David Sinclair The Empty Planet - Darrell Bricker The 100-Year Life - Lynda Gratton & Andrew Scott The Usefulness of Useless Knowledge -Abraham Flexner About The Inquiring Mind Podcast: I created The Inquiring Mind Podcast in order to foster free speech, learn from some of the top experts in various fields, and create a platform for respectful conversations. Learn More: https://www.theinquiringmindpodcast.com/ Instagram: https://www.instagram.com/theinquiringmindpodcast/ Facebook: https://www.facebook.com/theinquiringmindpodcast Twitter: https://twitter.com/StanGGoldberg Subscribe to the Inquiring Mind Podcast: Spotify: http://spoti.fi/3tdRSOs Apple: http://apple.co/38xXZVJ Google Podcasts: http://bit.ly/3eBZfLl Youtube: https://bit.ly/3tiQieE

Many critics and patients agree: The American health-care system is broken. They say the quality is poor, the cost is high and the system has a dominant disease-care orientation. "I would like to tell you that 21st century medicine should be about wellness and how we can get there," says Dr. Leroy Hood. "I have a vision of a data-driven health-care system where we can follow the health trajectory of each individual throughout their lifetime to optimize their wellness and healthy aging, while avoiding transitions to chronic diseases. Leroy Hood, M.D., Ph.D., is a recipient of the National Medal of Science, co-founder of the Institute for Systems Biology (ISB), and senior vice president and and chief science officer at Providence St. Joseph Health. Dr. Hood has played a role in founding 15 biotech companies, including Amgen, Applied Biosystems, Arrivale and Nanostring. In addition to having received 18 honorary degrees from prestigious universities in the United States and abroad, Dr. Hood has published more than 850 peer-reviewed articles and currently holds 36 patents.  Join us for a conversation about what you can do to begin practicing a new vision of 21st century medicine with a wellness orientation. MLF ORGANIZER: Robert Lee Kilpatrick SPEAKERS Leroy Hood M.D., Ph.D., Co-Founder, Institute for Systems Biology; Senior Vice President and and Chief Science Officer, Providence St. Joseph Health Robert Lee Kilpatrick Ph.D., Chair, Health and Medicine Member-Led Forum, The Commonwealth Club of California—Moderator In response to the COVID-19 pandemic, we are currently hosting all of our live programming via YouTube live stream. This program was recorded via video conference on May 19th, 2021 by the Commonwealth Club of California. Learn more about your ad choices. Visit megaphone.fm/adchoices

Many critics and patients agree: The American health-care system is broken. They say the quality is poor, the cost is high and the system has a dominant disease-care orientation. "I would like to tell you that 21st century medicine should be about wellness and how we can get there," says Dr. Leroy Hood. "I have a vision of a data-driven health-care system where we can follow the health trajectory of each individual throughout their lifetime to optimize their wellness and healthy aging, while avoiding transitions to chronic diseases. Leroy Hood, M.D., Ph.D., is a recipient of the National Medal of Science, co-founder of the Institute for Systems Biology (ISB), and senior vice president and and chief science officer at Providence St. Joseph Health. Dr. Hood has played a role in founding 15 biotech companies, including Amgen, Applied Biosystems, Arrivale and Nanostring. In addition to having received 18 honorary degrees from prestigious universities in the United States and abroad, Dr. Hood has published more than 850 peer-reviewed articles and currently holds 36 patents.  Join us for a conversation about what you can do to begin practicing a new vision of 21st century medicine with a wellness orientation. MLF ORGANIZER: Robert Lee Kilpatrick SPEAKERS Leroy Hood M.D., Ph.D., Co-Founder, Institute for Systems Biology; Senior Vice President and and Chief Science Officer, Providence St. Joseph Health Robert Lee Kilpatrick Ph.D., Chair, Health and Medicine Member-Led Forum, The Commonwealth Club of California—Moderator In response to the COVID-19 pandemic, we are currently hosting all of our live programming via YouTube live stream. This program was recorded via video conference on May 19th, 2021 by the Commonwealth Club of California. Learn more about your ad choices. Visit megaphone.fm/adchoices

Is aging a disease? How old does your body say it is? How can we live longer, healthier lives? Dr. David Sinclair, Harvard professor of genetics and bestselling author, joins ISB co-founder and genomics pioneer Dr. Lee Hood for a conversation about the very latest in aging research. David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics, Blavatnik Insitute, and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He has published over 200 scientific papers, is a co-inventor on over 50 patents, and is the New York Times bestselling author of Lifespan. He serves as co-chief editor of the scientific journal Aging. In 2018, he became an Officer of the Order of Australia (AO). Lee Hood, MD, PhD is a world-renowned scientist. Dr. Lee Hood co-founded Seattle’s Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. In 2016, ISB affiliated with Providence, and Dr. Hood became Providence’s Senior Vice President and Chief Science Officer. He is also Chief Strategy Officer and Professor at ISB. He is a member of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. Presented by Town Hall Seattle and KUOW. 

Institute for Systems Biology (ISB) is a collaborative cross-disciplinary nonprofit biomedical research organization based in Seattle. ISB and Town Hall proudly present ISB President Jim Heath in conversation with Rod Hochman, President and CEO of Providence. Join them for a discussion exploring what the future of healthcare might look like in a post-pandemic world. Dr. Jim Heath is a chemist and the president and professor of Institute of Systems Biology. He also has the position of Professor of Molecular and Medical Pharmacology at UCLA, and he has directed the National Cancer Institute-funded NSB Cancer Center since 2005. Dr. Rod Hochman is the president and CEO of Providence St. Joseph Health, a Catholic not-for-profit health system. He is the chair elect designate for the American Hospital Association (AHA), chair of AHA’s Regional Policy Board 9, and past chair of the board of trustees for the Catholic Health Association. Presented by Town Hall Seattle & Institute for Systems Biology. To become a Town Hall Seattle member or make a donation click here. 

Institute for Systems Biology (ISB) is a collaborative cross-disciplinary nonprofit biomedical research organization based in Seattle. In 2020, ISB is celebrating its 20th anniversary with a four-part virtual speaker series highlighting some of the most important topics in science and health care. ISB and Town Hall proudly present microbiome researcher and professor Dr. Eric Alm. Following Dr. Alm’s talk on low-cost pandemic tracking efforts in hundreds of cities, using data collected from sewage, he’ll be joined in conversation by ISB Assistant Professor Dr. Sean Gibbons for an in-depth discussion and audience questions. Dr. Eric Alm is a professor of biological engineering at MIT. He earned his PhD from the University of Washington, and then completed postdoctoral work at UC Berkeley and Lawrence Berkeley National Lab before joining the MIT faculty. His research focuses on non-invasive monitoring of human health, environmental surveillance, sewage epidemiology, and more. Presented by Town Hall Seattle and Institute for Systems Biology.  To make a donation or become a Town Hall Seattle member click here or text TOWN HALL to 44321. 

Institute for Systems Biology (ISB) is a collaborative cross-disciplinary nonprofit biomedical research organization based in Seattle. In 2020, ISB is celebrating its 20th anniversary with a four-party virtual speaker series highlighting some of the most important topics in science and health care. ISB and Town Hall proudly present Dr. Jennifer Reich, a Colorado-based sociologist who researches how individuals and families weigh information and strategize their interactions with state and service providers in the context of public policy, particularly as they relate to health care and welfare. Jennifer Reich, PhD, is Professor of Sociology at the University of Colorado Denver. She is the author of two award-winning books: Fixing Families: Parents, Power, and the Child Welfare System and Calling the Shots: Why Parents Reject Vaccines. Reich is also the co-editor of the book Reproduction and Society, and has written more than 30 articles and book chapters that explore childhood vaccinations, reproductive health, welfare, multiracial families, public assistance, and recovery following disaster. Presented by Town Hall Seattle and Institute for Systems Biology.

Dr. Ross is the Founder and CEO of the Brain Health & Research Institute “BHRI” based in Seattle, WA. BHRI has partnered with the Institute for Systems Biology “ISB” founded by Dr. Leroy Hood, MD. This partnership represents the unique union of science and clinical medicine. They hope that together they can identify and correct drivers of brain disease while making an impact on the global burden of brain illnesses worldwide.

Seattle’s Institute for Systems Biology (ISB) is revolutionizing science with a powerful approach to predict and prevent disease, and enable a sustainable environment. Join a panel of experts as they explore the cross-disciplinary and collaborative approach of systems biology and how it is applied in the exploration of new frontiers in biology and medicine. This moderated forum will provide a focused discussion on the advances in major areas that affect human health, at both an individual and global level.   Panelists include:    Moderator Clare McGrane, GeekWire  Dr. Leroy Hood, ISB and Providence St. Joseph Health  Dr. Howard Frumkin, University of Washington School of Public Health Dr. John Aitchison, Center for Infectious Disease Research   Recorded live at Institute for Systems Biology by Town Hall Seattle on Wednesday, March 7, 2018. 

Get ready because this episode takes us 5-10 years into the future - where Big Data meets Alzheimer's. But the future is already here! Dr Nathan Price PhD is the associate director of the highly esteemed Institute for Systems Biology (ISB) and co-founder of it's spin-off company Arivale - a leading company in the Scientific Wellness space. ISB and Providence St. Joseph Health, a 50 hospital system to which ISB is affiliated, have particularly focused on solving Alzheimer’s and have invested millions of dollars into research in finding both cures and prevention programs. Dr Price gives us an intro to the concept of "Scientific Wellness" and it's role in creating health and predicting and preventing disease.  Scientific Wellness - refers to technologies that quantify and assist to enhance health in the human body.  Using methods of measurement called "Computational Biology" this approach builds models to make sense of disease and resilience states and gain insights from vast amounts of information generated using computer technology.  This information can be from a person's genes or gene expression products or even the bugs in their stool and saliva. In some cases these methods may even try to make sense of data streams collected by a variety of sensor-based information (for example, from a FITBIT).   All of this information can be overwhelming to handle and requires "supercomputing" capacity which companies like Arivale and ISB possess. Dr Price and I discuss how all of this information comes together in the case of Alzheimer's disease in the form of "dense dynamic personal data clouds" and how this will likely be important in solving the Alzheimer's puzzle.  Dense dynamic personal data clouds - refer to huge data sets that are followed on individuals over time to help predict and prevent disease. The first such project was called the "Pioneer 100." While some of these data collections are investigational at this time, the near term goal is to leverage these data to practical help people get better or possible prevent Alzheimer's.  In order to make sense of an individual's information, his/her genome need to be compared against what is know about Alzheimer's in the highly touted Genome Wide Association Studies (GWAS).  GWAS data are important because they tell you about gene variations that are associated with a variety of aspects of Alzheimer's disease. Fortunately, there is good GWAS data for Alzheimer's and based on this, Dr Price and his team at Arivale believe that this will help track the manifestation of Alzheimer's disease based on tracking way the way genes express in a variety of other measurable data from a human being. This information is collected from multiple levels of a person including stool, saliva, urine, blood and potentially more. The variety of levels of "Omic" information is aggregated then with the assistance of computer technology is made sense of in the form of a "dense dynamic personalized data cloud." Other Interesting Topics discussed in this episode Connections between diabetes type 2 and Alzheimer's a Where stem cells might have a role in treatment. CRISPR technology - the benefits and ethical questions of gene-editing technology. I want to highlight CRISPR in this summary because of how significant it appears it will be in the future of achieving real health on multiple levels.  CRISPR is a gene-editing tool - that Dr Price calls one of the most exciting developments in biology in his generation. CRISPR is a simple technique for gene editing that allows someone to effectively "pull out" risky genes at the stem cell level, fix them, and put them back. But, Dr Price also considers the ethics and potential unintended consequences. Changing the paradigm of how clinical research is done in the Information Age.  In the age of Personalized Medicine the paradigm of the single pill for a single ill is being challenged and a new approach for clinical trials is emerging with ISB amongst the leaders of this emerging paradigm.  Find out more about Dr Price's work here: The Institute for Systems Biology Arivale

Seattle’s Institute for Systems Biology (ISB) is revolutionizing science with a powerful approach to predict and prevent disease, and enable a sustainable environment. Explore the cross-disciplinary and collaborative approach of systems biology and how it is applied in the exploration of new frontiers in biology and medicine. This moderated forum will provide a focused discussion on the advances in major areas that affect human health, at both an individual and global level. Panelists include: Moderator Ross Reynolds, KUOW Dr. Leroy Hood, ISB and Providence St. Joseph Health Dr. Steven Kern, Bill and Melinda Gates Foundation Dr. Mike Snyder, Center for Genomics and Personalized Medicine, Stanford Gregg Small, Climate Solutions Recorded live at Town Hall Seattle Monday, April 3, 2017