Podcasts about omic

L'Oficina Municipal d'Informació al Consumidor va realitzar el 2024 un total de 742 gestions, de les que 224 van derivar en expedients de reclamació, queixa o denúncia de consum. L'ells, 206 va ser propostes de mediació, en 161 casos l'establiment va acceptar la mediació, i en 80 d'ells la resolució va ser favorable a la persona consumidora. La majoria de casos corresponen a reclamacions davant d'asseguradrores, empreses de transport, professionals de la llar o entitats bancàries, tot i que també hi ha força expedients sobre empreses subministradores (aigua, llum i gas). Hem repassat les accions en l'espai mensual amb la responsable de l'OMIC a Sitges, Sandra Clark. L'entrada Espai OMIC: balanç del 2024, amb 80 resolucions favorables al consumidor ha aparegut primer a Radio Maricel.

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Además, sugieren el comercio de proximidad puesto que “es mucho más fácil tratar con un comercio cuyo objetivo es fidelizar clientes”

Continuant amb la causística sobre les assegurances, a l'espai que mensulament dediquem a l'Oficina Municipal d'Informació al Consumidor, amb la Sandra Clark avui hem conversat amb en Francesc Núñez, mediador d'assegurances, que ens ha aclarit alguns aspectes, com la necessitat de ser conscient de què assegurem. En aquest sentit, la figura d'un mediador pot ser útil a l'hora de parlar amb l'asseguradora per resoldre un sinistre, i per detectar aquells aspectes del contracte que puguin servir per la reclamació. L'entrada Espai OMIC: les assegurances i els mediadors ha aparegut primer a Radio Maricel.

Hablamos con Teresa García de la Omic de Alfacar sobre los mecanismos de Protección del Consumidor Bancario

L'organitza l'OMIC dimecres 27 de novembre al casal municipal de la gent gran.

L'Oficina Municipal d'Informaci

La catàstrofe de la DANA a València ens ha fet pensar en les assegurances, aquells contractes que només treus del calaix quan hi ha algun problema. N'hi ha de molts tipus (vida, salut, llar, vehicles...), i dintre d'ells, una multiplicitat de tipologies i causístiques. I si arriba un desastre, potser no ens garantiran la cobertura, però la seva existència ens permetrà tenir accés al Consorci de Compensació d'Assegurances. Amb la Sandra Clark, de l'Oficina Municipal d'Informació al Consumidor de l'Ajuntament de Sitges, hem fet una ullada al complex món de les assegurances. L'entrada Espai OMIC: les assegurances ha aparegut primer a Radio Maricel.

El programa 'Hoy por Hoy Bilbao-Bizkaia' sitúa la realidad del consumo en el centro de su cita con la audiencia de Radio Bilbao. En un día en el que abordamos con los colectivos, a priori, más vulnerables, la cita con el consumo nos traslada a nuevas estafas registradas en la Oficina Municipal de Información, OMIC 

AFN är tillbaka och nu slår de på den stora trumman! Inför 8:e upplagan kommer vi få se fjäder- och welterviktsturneringarna avgöras, Machete försvarar sitt guld, Liam pitts gör proffsdebut, Samuel Bark gör kanske sin sista match utanför UFC, Megic Mike gör A-klass debut och Valentino Demina och Johannes Leonidas gör MMA-debut. Francis Ngannou är tillbaka i MMA i helgen också och innan han kliver in i buren så slåss bland de främsta utövarna i MMA som inte är i UFC, i PFL buren i Riyadh, Saudi Arabien.     Rondvilan på sociala medier: Rondvilan YouTube Rondvilan Instagram Rondvilan TikTok Timestamps: (00:00) Intro (06:19) AFN äger rum i ny arena! (11:26) Bark vs Monteiro (15:55) Vologdin vs Baptista (19:07) Pitts vs Nejara (23:40) Kralj vs Luna (26:22) Machete vs Ruano (29:39) Influencers (30:00) Ringvall vs Anvarov (33:50) Persson vs Hogstad (34:43) Håkansson vs Omic (40:40) Azizi vs Valegren (45:20) Sebbes influencerkollegor intar arenan (51:40) Sporttouchen intar också arenan (52:22) Ngannou vs Ferreira (1:02:53) Cyborg vs Pachecho (1:04:53) Eblen vs Edwards (1:09:24) McKee vs Hughes (1:12:25) UFC i helgen Lyssnarfrågor  (1:13:36) Fler event framöver? (1:14:00) Tankar om AFN matchordningen? (1:15:16) Krav för att Bark blir nästa stora export? UFC-potential? (1:17:35) Predictions AFN/PFL?  (1:19:16) Tankar om influencermatcher högre på kortet än fighters?  (1:22:02) Om inte ”face the pain”, vilken kan vara UFC-låten? (1:23:24) Ngannous status som megastjärna död vid förlust?    (1:25:10) Sammanfattning inför helgen (1:26:30) LIKE SHARE SUBSCRIBE

Hablamos con Teresa García de la Omic de Alfacar sobre la forma correcta y ágil de poner una reclamación a cualquier establecimiento.

Durant el mes de juliol, tècniques de la Diputació de Barcelona varen visitar un centenar d'establiment del centre de Sitges en una campanya informativa sobre el grau de compliment del Codi de Consum de Catalunya. A partir d'entrevistes, es va constatar diverses mancances relacionades amb la informació de cara al consumidor (exhibició d'horari o de preus), la inexistència de fulls de queixa, reclamació i denúncia, la informació dels tíquets, o la redacció com a mínim en català. El grau de compliment difereix bastant segons la tipologia d'establiment, tot i que majoritàriament van mostrar disposició per arranjar les mancances. N'hem pogut parlar amb la cap del departament de Promoció Econòmica de l'Ajuntament de Sitges, Tina Ratés, amb la tècnica de Consum de la Diputació Núria Vega, i amb la tecnica de Consum de Sitges i responsable de l'OMIC Sandra Clark. L'entrada Espai OMIC: el compliment del Codi de Consum ha aparegut primer a Radio Maricel.

Hablamos con Teresa García de la Omic de Alfacar sobre la factura de la luz y consejos para ahorrar en la factura.

Heu viatjat amb avió aquest estiu? Heu tingut problemes amb retards, cancel·lacions o pèrdua d'equipatge? L'Oficina Municipal d'Informació al Consumidor (OMIC) de l'Ajuntament de Sitges us pot ajudar. Però abans cal fer sempre una primera reclamació individual a la companyia, i l'incident no ha de ser imputable a circumstàncies alienes a la companyia, com temporals meteorològics o caigudes globals de sistemes informàtics. Així, per saber si una reclamació pot ser atesa, cal entrar molt en la causística i la lletra petita, un assessorament que ens poden donar des de l'OMIC. Amb la Sandra Clark hem repassat casos d'un dels principals motius de queixes dels consumidors: el transport aeri. L'entrada Espai OMIC: problemes amb vols ha aparegut primer a Radio Maricel.

Cartoonist, animator, and author Dash Shaw joins us to discuss his new graphic novel, Blurry, which examines the small life choices that lead to bigger life change. Plus, we discuss his film "Cryptozoo," which will be screening at Roxy Cinema on Sunday at 7 pm.*This segment is guest-hosted by Kousha Navidar 

Conexión con el campamento urbano de la OMIC 

Hablamos con Teresa García de la Omic de Alfacar sobre la factura de la luz. Para ayudar a entenderla y a ver los distintos tipos de contratos que hay en el mercado, si tienes algún seguro adicional contratado y las condiciones de tu contrato. bono social eléctrico y bono social térmico...

Cebrián explica qué tipo de reclamación ha sido la más frecuente

A l'estiu acostuma a ser més comú anar a establiments de restauració. La Sandra Clark, des de l'Oficina Municipal d'Informació al Consumidor, ens ha recordat els drets i deures que tenen els consumidors a bars i restaurants, i que inclouen els drets lingüístics -la carta com a mínim en català, i la comunicació en qualsevol dels idiomes oficials, sense poder obligar l'interlocutor a canviar-lo-, drets d'informació sobre menús, serveis específics o cobraments, i drets econòmics -preus amb IVA, menús ben especificats, desglossament de conceptes al tiquet o propines voluntàries-. De tota manera, el tant per cent de queixes i reclamacions sobre aquests conceptes acostuma a ser baix. L'entrada Espai OMIC: drets i deures a bars i restaurants ha aparegut primer a Radio Maricel.

I helgen gick AFN 7 av stapeln samt UFC 303. Vi fick se fina avslut och folk som hoppade av matcher i sista sekund, i både Stockholm och Las Vegas. Med oss för att gå igenom galorna har vi AFNs egna announcer Sebastian Vendel-Martinez. Häng på! Rondvilan på sociala medier : Rondvilan YouTube Rondvilan Instagram Rondvilan TikTok (00:00) Intro (05:19) AFN Recap intro (05:50) Vinicius Moraes hustlar AFN (08:07) Machete vs Marczuk (11:58) Berisha vs Owsiany (15:21) Hajijan vs Elias (20:16) Abbasov vs Turchiniak (22:32) Itayev vs Grbic (26:58) Galecki vs Xhafolli (29:09) Azizi vs Husein (32:45) Jacobsson vs Bukovskis (38:08) Håkansson vs Tomic (40:09) Omic vs Lövgren (44:03) Vacoev vs Larsson (48:17) Tokhirov vs Damarkani (51:00) Mangs vs Yousifi (54:17) Gidaev vs Karlsson (56:14) Sinclair vs Shadad (56:55) Ksia vs Youssef (59:24) Khaistagul vs Magomedov (59:54) UFC 303 recap (1:01:35) Ratko Tomic är ödmjuk (1:03:36) Poatan snusar (1:05:19) Poatan vs Prochazka (1:06:26) Pereira UFCs största stjärnan? (1:07:25) Power Slap  (1:09:22) Herb Dean sent stopp? (1:10:13) Lopes vs Ige (1:14:16) Dolidze vs Smith (1:15:40) Bueno Silva vs Chiasson (1:16:23) Machado Garry vs MVP (1:24:19) Riyadh Season Noche UFC (1:28:30) Memes

El programa 'Hoy por Hoy Bilbao-Bizkaia' sitúa la realidad del consumo en el centro de su cita con la audiencia de Radio Bilbao. Una nueva sección para analizar los últimos casos que ayuden al consumidor a defenderse o a plantear cuestiones al sector comercial. Hoy, junto a las organizaciones de comercio de Bizkaia hablamos de sostenibilidad.

Com a consumidors ens podem trobar amb una carta en què ens reclamen un deute que desconeixem, moltes vegades sense més dades. Davant d'això, el primer és assaventar-se de què ens demanen, i esbrinar si el deute és real i si ha prescrit o no, i fer les passes pertinents, per tal d'evitar tenir problemes amb la incursió en un fitxer de morosos. L'Oficina Municipal d'Informació al Consumidor s'hi ha trobat amb diversos casos, i en cas de dubte, pot ajudar a gestionar-ho. Ens ho ha explicat la sandra Clark. L'entrada Espai OMIC: i si ens reclamen un deute que desconeixem? ha aparegut primer a Radio Maricel.

La Sandra Clark, des de l'espai de l'Oficina Municipal d'Informació al consumidor (OMIC) de l'Ajuntament de Sitges, ens acosta avui un cas que ha afectat a alguns clients de comercialitzadores de llum: de cop deixen de rebre la factura i els seus càrrecs bancaris. En aquests casos cal reclamar, per evitar que ho girin tot de cop i, si ho fan, demanar una mediació o un arbitratge que alleugereixi el pagament. L'entrada Espai OMIC: vigilem si deixen de facturar-nos la llum ha aparegut primer a Radio Maricel.

Recordamos y completamos lo comentado ayer sobre los festivales Folkarria y La Veguilla Folk Festival. Ahí están hoy Fetén Fetén, pero aprovechando que por este último pasará el próximo domingo, 27 de abril, Carlos Soto, estrenamos lo que va a ser su tercer disco, “Barrio Mudéjar”, ya sin la coletilla Castijazz, el proyecto por el que se ha dado a conocer en sus últimos años. Pero se hace inapelable remachar que estamos en abril, el tiempo de los claveles, del desamor, de la taberna de Turmo y de las revoluciones. Con un Grándola en el corazón, así suena La Tarataña esta madrugada: 1.- Fetén Fetén, “Pasodoble del Magreb” 4:182.- Carlos Soto (aka Castijazz), “La comida la manyana” 3:50, “Barrio Delicias” 5:55 y “Entradilla” 5:203.- Celtas Cortos e invitados, “20 de abril” 5:214.- Luis Pastor y Javier Ruibal, “Aguas abril” 3:365.- Luis Pastor y Pedro Pastor, “Abril del desamor” 2:426.- Los remeros del Zapardiel, “Vengo de moler” 3:427.- Abril, “Frades” 3:158.- Bargainat, “Omic” 5:039.- Jose Zeca Afonso, “Grándola Vila Morena” 3:14Escuchar audio

El proper 19 d'abril tindrà lloc una xerrada adreçada a consumidors i establiments sobre els requisits mínims en les relacions de consum. En l'espai de l'Oficina Municipal d'Informació al Consumidor, la Sandra Clark ens ha repasat aquests requisits, que es fonamenten en el dret a la informació (que inclou des dels horaris o els preus de venda fins a les polítiques de devolucions), a la protecció de la salut i a la seguretat (com s'han d'etiquetar els riscos), a la protecció dels interessos econòmics (sobre tíquet, factura, rebut o pressupost), a la indemnització (les reclamacions) i els drets lingüístics (a ser entès en les dues llengües oficials, i a l'etiquetatge en català). L'entrada Espai OMIC: requisits mínims de les relacions de consum (i 2) ha aparegut primer a Radio Maricel.

El proper 19 d'abril tindrà lloc una xerrada adreçada a consumidors i establiments sobre els requisits mínims en les relacions de consum. En l'espai de l'Oficina Municipal d'Informació al Consumidor, la Sandra Clark ens ha repasat aquests requisits, que es fonamenten en el dret a la informació (que inclou des dels horaris o els preus de venda fins a les polítiques de devolucions), a la protecció de la salut i a la seguretat (com s'han d'etiquetar els riscos), a la protecció dels interessos econòmics (sobre tíquet, factura, rebut o pressupost), a la indemnització (les reclamacions) i els drets lingüístics (a ser entès en les dues llengües oficials, i a l'etiquetatge en català). Una regulació molt completa, que en molts casos respon al sentit comú. L'entrada Espai OMIC: requisits mínims en les relacions de consum ha aparegut primer a Radio Maricel.

Técnicos, clientes y comerciantes lanzan un mensaje en el Día Mundial de los Derechos del Consumidor reivindicando la calidad del producto por encima de otros factores

Helgen 17-18 februari blev Emin Omic den yngsta att vinna Svenska Mästerskapen i MMA Klass-A och är nu tvåfaldig svensk mästare. Med bara 2 års träning är det inget annat än imponerande och representerar nu svenska MMA-landslaget i -77kg. Redan dagen efter SM så fick vi möjlighet att prata med den unga begåvningen ifrån Örebro. Han delar med sig bl.a om sin resa som han har gjort inom kampsporten, hur har tänker och förbereder sig inför kamp samt vad framtiden håller. Vi får även gå in på vad som är hemligheten bakom Örebro Fight Gyms framgångar, med tränare Patrik Hjulström och Malin Hermansson i spetsen, samt huruvida han har tänkt något på sina möjligheter att representera landslaget och vad skulle betyda för honom isåfall. Rondvilan YouTube Rondvilan Instagram Rondvilan TikTok

Amb la Sandra Clark, de l'Oficina Municipal d'Informació al Consumidor de l'Ajuntament de SItges, hem repassat els diversos conceptes que podem trobar a la factura de l'aigua, i que, a més d'entendre-la, ens poden ajudar a detectar si hi ha algun problema. A més, en aquest marc de sequera, hem recordat alguns petits trucs útils per estalviar-ne. L'entrada Espai OMIC: la factura de l’aigua i consells per estalviar-ne ha aparegut primer a Radio Maricel.

Estem en periode recomanat de rebaixes, un concepte específic i clarament regulat per la legislació. En l'espai de l'Oficina Municipal d'Informació al Consumidor, amb la Sandra Clark, hem repassat aquells conceptes que venedors i compradors han de tenir clar sobre les rebaixes: que han d'estar clarament indicades, que l'objectiu és alliberar estocs o que els sistemes de pagament i devolució són els mateixos que fora de rebaixes. Unes rebaixes que han perdut pes en ja no ser un periode obligatori, però que tenen la seva importància com a dinamitzadores de l'activitat comercial. L'entrada Espai OMIC: què vol dir estar de rebaixes? ha aparegut primer a Radio Maricel.

Com cada any, l'arribada del Nadal representa una explosió del consumisme. I cal parar atenció per tenir clar què comprem, què necessitem, si podem fer compra de proximitat i sostenible, els drets que tenim, i els que no, si hem de retornar allò comprat. I amb especial atenció en el cas de les joguines. N'hem parlat amb la Sandra Clark, de l'OMIC de Sitges. L'entrada Espai OMIC: recomanacions per a les compres de Nadal ha aparegut primer a Radio Maricel.

En l'espai de l'OMIC, amb la Sandra Clark, continuem repassant els drets dels passatgers i les formes de reclamar, davant d'un dels sectors que més queixes genera entre els consumidors. Són tres les principals incidències: retard (es considera com a tal a partir de les dues hores), cancel·lació de vol i denegació d'embarcament. I el que és fonamental és, el mateix dia que ens passi, deixar-ne constància escrita, sigui amb els fulls de reclamació al mateix aeroport, sigui al correu electrònic de la companyia. Després, conservar tots els tiquets que demostrin el greuge que ens ha suposat la incidència. I a partir d'aquí, si la resposta que rebem és insuficient o inexistent en un mes, triar el procediment, sigui la mediació que ofereixen les oficines de consum, sigui la reclamació directa. L'entrada Espai OMIC: les reclamacions d’incidències en el transport aeri ha aparegut primer a Radio Maricel.

Tot i que la Unió Europea compta amb una de les normatives més garantistes amb els dret dels passatgers de transport aeri, la vulneració d'aquests drets és moneda recurrent. Cancel·lacions de vols, retards, sobreocupació i problemes amb l'equipatge generen maldecaps i queixes entre els afectats. La normativa és clara, però si ens passa qualsevol cosa, hem de seguir les passes i complir els terminis per tenir dret a compensacions. Ens ho ha explicat en l'espai OMIC la tècnica de Consum de l'Ajuntament de Sitges Sandra Clark. L'entrada Espai Omic: Els drets dels passatgers en el transport aeri ha aparegut primer a Radio Maricel.

An interview with Drs. Sharoni Jacobs and James Lu, from Helix, Inc. on the role of Omic technologies in modern medicine and the future opportunities it opens for the ASHI community.

Making Ottawa a Music City! Dawg and Gus have an fantastic sit down to chat with Melanie Brulee of OMIC ( Ottawa Music Industry Coalition ). Melanie ( a woman with many musical hats ) lets us in on the process of what it takes to make the Music Community in the city of Ottawa work. From the Capital Music Awards, Songs From The Shed and City Sounds Melanie gives us a little glimpse into the world that she now lives in and what it takes to promote the amazing and talented individuals we have in this city of ours. So come join us as Melanie takes us through her travels and her journey to being here in Ottawa and working with her amazing OMIC team to bring to all of us the talent that we NEED to know about and support!! And as always find out is she is a 80s or 90s kinda gal!! All this and MUCH more!! ( MAYBE even an event with Dawg and Gus ) Remember to support your local artists and venues and also.... you can become a member of OMIC so you don't miss out on any of the wonderful musical events happening in the city. Much love, Dawg and Gus

Comencem un nou espai dedicat a l'Oficina Municipal d'Informació al Consumidor (OMIC) de Sitges per anar oferint consells sobre les incidències relacionades amb el consum i la compra de productes i serveis. La Sandra Clark ens ha presentat l'oficina, que atèn, assessora, i fa formacions tant per a consumidors com per a comerciants. Tot i que es reven moltes consultes, el gruix de la feina el representen les reclamacions, que és el procediment en què l'Ajuntament actua com a mediador, sense que se'n derivi una denúncia. Per últim, hem repassat el darrer canvi legislatiu que prohibeix les trucades comercials no consentides. L'entrada Espai OMIC: reclamacions i informació a l’abast de consumidors i comerciants ha aparegut primer a Radio Maricel.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.28.530493v1?rss=1 Authors: Khatib, T. O., Amanso, A. M., Pedro, B., Knippler, C. M., Summerbell, E. R., Zohbi, N. M., Konen, J. M., Mouw, J. K., Marcus, A. I. Abstract: Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized our understanding of heterogeneity, in isolation they cannot correlate phenotypic information within a physiologically relevant live-cell state, with molecular profiles. This inability to integrate a historical live-cell phenotype, such as invasiveness, cell:cell interactions, and changes in spatial positioning, with multi-omic data, creates a gap in understanding cellular heterogeneity. We sought to address this gap by employing lab technologies to design a detailed protocol, termed Spatiotemporal Genomics and Cellular Analysis (SaGA), for the precise imaging-based selection, isolation, and expansion of phenotypically distinct live-cells. We begin with cells stably expressing a photoconvertible fluorescent protein and employ live cell confocal microscopy to photoconvert a user-defined single cell or set of cells displaying a phenotype of interest. The total population is then extracted from its microenvironment, and the optically highlighted cells are isolated using fluorescence activated cell sorting. SaGA-isolated cells can then be subjected to multi-omics analysis or cellular propagation for in vitro or in vivo studies. This protocol can be applied to a variety of conditions, creating protocol flexibility for user-specific research interests. The SaGA technique can be accomplished in one workday by non-specialists and results in a phenotypically defined cellular subpopulation for integration with multi-omics techniques. We envision this approach providing multi-dimensional datasets exploring the relationship between live-cell phenotype and multi-omic heterogeneity within normal and diseased cellular populations. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This week we sit down with Patrick Engleman founder of the Lu Lacko Wyco Hundo gravel event in Pennsylvania. In its 10th running this year, LLWH is a staple of the Pennsylvania gravel scene. Episode sponsor: Athletic Greens Support the Podcast Join The Ridership  Automated Transcription, please excuse the typos: [00:00:00] Craig Dalton: Hello, and welcome to the gravel ride podcast, where we go deep on the sport of gravel cycling through in-depth interviews with product designers, event organizers and athletes. Who are pioneering the sport I'm your host, Craig Dalton, a lifelong cyclist who discovered gravel cycling back in 2016 and made all the mistakes you don't need to make. I approach each episode as a beginner down, unlock all the knowledge you need to become a great gravel cyclist. [00:00:28] Craig Dalton: This week on the show. We welcome Patrick angle. Then from Lou LACO Waco. Hundo. It's a real tongue twister of an event. Out in Pennsylvania. That's been going on for 11 years. This is the 10th edition as Patrick will describe another one of those great events. That's been flying a little bit under the radar. Unless you lived in that Pennsylvania and mid Atlantic area where it's on everybody's to do list. I wanted to get you guys to know this event because it's another one of those great events. That's started by someone who just loves the community that they ride in. And wanted to highlight it and bring friends. Patrick's done a great job of growing the event and talk to anybody in that region. And they'll definitely reference some of the memorable experiences. They've had over the years with this event. Before we jump in, I need to thank this week. Sponsor athletic greens. Athletic greens and their product. AIG one has pioneered the category of functional health. Agg one replaces key health products. All in one simple scoop. As I've mentioned before, my daily routine is mixing a scoop of ag one with some ice. Shaking it up and taking it down. What I love about this product is is it replaces key health products with one simple scoop AIG one combines nine health products working together as one, replacing your multivitamin multimineral pre and probiotics immunity support and more, this means AIG one does more for your body, saves you time and money and confusion compared to taking multiple unique products. I've admitted it before and I'll admit it again. I'm not the best at covering my nutritional basis, which is why AIG one has been part of my routine for five plus years. At this point. With the highest quality ingredients aIG one is made up of 75 high quality vitamins minerals, and whole food source, nutrients, and manufactured with the strictest quality standards. Okay. It's even N S F certified for sport. A robust certification process that involves ingredient and finish batch testing of AGU 180 1 tastes great and feels even better. I know for me, it's just that nutritional guarantee. 81 tastes great and makes me feel even better. If you're interested in checking ag one out, go check out athletic greens.com/the gravel ride. They're going to give podcasts listeners a free one-year supply of vitamin D. As well as five free travel packs with your purchase. Remember that URL is athletic greens.com/the gravel ride. . Would that important business out of the way, let's jump right into my conversation with Patrick. [00:03:14] Craig Dalton: Patrick, welcome to the show. Oh, thanks for having me. I'm excited to have this conversation. I'm gonna make my attempt at pronouncing the event name first, and I'm just gonna take my best guess. Okay. Try it. Lulac Waco [00:03:28] Patrick Engleman: Hyundai. That's kill, you're killing it for, especially for a west coaster. Uh, that was perfect. [00:03:32] Craig Dalton: Um, I don't think I could do it fast. It took me, I like trained myself several times prior to hitting record to say that [00:03:39] Patrick Engleman: it's all part of the. Right is how many times you have to repeat it to say it. And also it has been shortened to lulac, uh, just because it's much easier for folks. But it's the lulac, uh, it's the Luzerne, Lakana and Wyoming counties and it's a hundred miles. Uh, so that's kind of where it started was the three counties that we ride through and I just kind of pulled from there. And started the name, and actually I started the, I got the name if you wanna know this a little bit. Um, I was resting at the top of a long climb and there happened to be carvings of Native Americans, like wood carvings of Native Americans on, I guess someone's driveway. And there were three of them. And part of the genesis of this was I, I looked out of the over the valley and said, what would they have? Of what I'm seeing right now and, and kind of thought about them as three separate people and them thinking about their account, like represented at that time and you know, all these other stuff. So that's kind of where the name came from and, you know, my little inspiration point, uh, out somewhere in the middle of nowhere right on the bike, . So. Nice, [00:04:37] Craig Dalton: nice. Well, we're gonna get into that a bit and it's, uh, is it the 10th year or the 11th year coming up? [00:04:42] Patrick Engleman: So it, because of Covid, I've obviously, we know it's the, this is the 11th year, it's the 10th ride. So we, we lost a ride. [00:04:49] Craig Dalton: We lost a ride in there. Gotcha. And from having Dave Pryor on the podcast and from previously listening to Celine talk on podcasts, I'd heard the name on our number of occasions in the context of like, oh, these are the ones we do every year in Pennsylvania. They're just part of what everybody does, and it's the kind of coming together of the community. So we'll get into that, but let's talk first. Where are you [00:05:18] Patrick Engleman: in the world? So I'm currently sitting, uh, in a town called WinCo, Pennsylvania, which is just in the, uh, suburbs of Philadelphia, the northeast suburbs of Philadelphia. [00:05:27] Craig Dalton: Okay. And where is [00:05:28] Patrick Engleman: the event? The event starts in Pittston, Pennsylvania, my hometown, uh, which is the northeast, which is the northeast corner of Pennsylvania. Uh, not, not just northeast, uh, suburbs of Philadelphia. So [00:05:40] Craig Dalton: you're drawing, if geographically you're drawing it sounds like. riders in New York, riders in Eastern and western pa riders in DC jersey maybe can all get you within two to four [00:05:52] Patrick Engleman: hours. Yep. Yeah, generally, um, we usually say the Megapoli, so like the Boston and DC uh, or Bo Boston and now Northern North Carolina seems to be where it's at. And then Western and then way some, some folks, our, uh, one of our folks, uh, is, comes in from Alaska every year. Uh, but he's a, he's a local, but he does come in from Alaska every year. It's like one of his trips. Yeah, [00:06:13] Craig Dalton: nice. Stepping back for a minute, let's just start, set the stage for kind of your background as a cyclist. Um, you mentioned where you grew up and, and some of the love that you found early on as a child. . [00:06:26] Patrick Engleman: Yeah, I mean, I, I grew up, you know, like riding like everybody, I'm, I'm the youngest of all my cousins, so I got the hand me downs of the hand me downs with the hand me downs. So I, I wrote anything there was, and that's kinda what we did in my neighborhood. Like, I was very lucky to have lots of friends in my neighborhood and we just rode and spent a lot of time in the woods. Uh, I grew up with just a ba My backyard is, It goes into, you know, so, so far when we were kids, it was so many miles of woods and, you know, there's just so much to explore. So I just grew up riding mount, you know, we were riding mountain bikes on our bmx, uh, when we were, you know, little kids. And also, yeah. Um, part of my riding background is, is my, my dad didn't drive, uh, for a lot of my life and he didn't, uh, for lots of reasons, but where I grew up, there's not a lot of mass transit. Um, so we had a little, we had like a bus, like every hour. Um, so. He rode. He rode or walked. So I rodee or walked because I, there's no other way to get around. My mom sometimes worked mid. Yeah. Uh, uh, second shift. So like we just rode all the time. Yeah. What, [00:07:22] Craig Dalton: what was, uh, you know, as you got a little bit older, was there a Pennsylvania cycling scene that started to draw you in? Or were you like many athletes you. You know, cycling as we think of it now, really wasn't part of your life until, you know, your twenties or what have you. [00:07:37] Patrick Engleman: I I, I was in it pretty young. I mean, I think because, because of where I grew up and there was a, a decent, um, mountain bike scene, uh, growing. I, I, I grew up you high school in the mid nineties, and I was very lucky to find, uh, a great, a great local bike shop that kind of took me in as like their like baby brother. Uh, they were all in their twenties and a little older and racing mountain bikes, but I was. The shop rat who wouldn't go home and, you know, could also kind of hang with them. And that's where it all, where it all kind of came from. So I was riding mountain bikes in high school and, you know, continued on. Uh, and then while once I went to college, uh, I became, I became a bike messenger. I went to Temple University in Philly and I became a bike messenger and kind of got in that world while still racing mountain bikes and riding mountain bikes and, um, have kind of stayed with it, worked in shops and did all the things. It's definitely been a part of my life for a long. [00:08:26] Craig Dalton: Yeah, it's something, you know, it's, you know, people on the West coast may not know this, but Pennsylvania in general has such a great cycling community. And to your point, I was in school in Washington, DC in that early nineties period in college and all the mountain bike racing. A lot of it we, what we did was go up to Pennsylvania at, to race mountain bikes. Mm-hmm. , it was great and so many. Just great like community style events where the terrain was awesome, but the community was even better. Mm-hmm. . Yeah, we had [00:08:58] Patrick Engleman: a lot, we had a lot of that. We were very lucky to have a lot of great events and great places to ride. I grew up not far from Jim Thorpe, which is, you know, any, any, any person of our vintage. Here's Jim Thorpe in the East Coast, knows how legendary it was. And, you know, uh, UCCI wasn't, is not far from where, from me and like, you know, just a bunch of really classic places. But also, like I said, my backyard is pretty amazing , so it still is. [00:09:20] Craig Dalton: And then as you, as you transitioned to your kind of professional career, were you. Kind of racing mountain bikes once a year. Do you define the road? What was your kind of transition in those, those later [00:09:30] Patrick Engleman: years? Uh, those later years? I was, so I was, uh, teaching actually in Northern Virginia, uh, like we were talking about. And I, um, I ride to work. I mean, and I, and I was working, I was working at a shop part-time. I'm a teacher, so I was like, make a couple bucks and I had the summer off and I'm just used to being a shop rat. So I was working at City Bikes in DC Nice. And kind of stuck, kind of stuck with it. I've raced cross for a, a little while there. Um, still once in a while I'll line up on a mountain bike, but I, a lot of my time now is just kind of riding with friends and, you know, checking out new places to go and, you know, traveling a bit. Um, I also mentioned, I, I helped found the Pennsylvania Inters Classic Cycling League, so it takes a lot of, uh, a lot of my time riding is kind of transitioned into bringing more kids in, in more, more adults. Uh, I was coaching, coaching the coaches for a long time, uh, so bringing a lot of the coaches into it and, you know, kind of instructing that. So stuck with it and, but I've done a bunch of different. Right on. [00:10:21] Craig Dalton: And by the way, just thank you for doing the work with Scholastic Mountain biking. I think it's great. I mean, obviously here in Northern California we've got this great Nike scene out here and yeah. Gosh, I wish it existed when, when I was growing up. Yeah. And I know that. Takes a lot of effort from a coaching perspective, from an infrastructure perspective, and it takes someone to just hold up their hand and be willing to put in the work. So thank you for doing that. [00:10:45] Patrick Engleman: Yeah, no problem. I'm, I'm, I'm, it's, it's, it's, it's, seriously, like I, I wrote a long time ago what my dream job would be, and it was teaching mountain biking. and I got to do it, you know, I got, I got to do it for, you know, a few thousand kids and a bunch of coaches. So I, I definitely got to live my dream. So I'm, now I step back a little bit to do some more work on this, but I'm still on the board of, uh, board of advisors for the Pennsylvania League, and I work a little bit with, with Nica as a whole and do some of that stuff. Cause I, I love it. You know, I love, I, I'm, I'm a teacher, so I love, I obviously love kids, but I love mountain biking too, and I get to do both, um, you know, [00:11:15] Craig Dalton: both passionate. Yeah. You know, it sounds like from, from your description and all the different types of bikes you were riding, having a cyclocross bike, you know, 20 years ago or whenever you did, did the emergence of gravel, as we talk about it today, was it just one of those things that you'd already been doing that effectively on those bikes? [00:11:34] Patrick Engleman: Uh, yeah, effectively, I mean, I was riding, um, I was riding, we got invited to a Rafa ride, uh, and we, we rode some of actually where, what an event Dave Pryor promotes now called Monkey Night Fight. Um, at the time he wasn't, he wasn't the promoter yet, but we rode some of those trails and some of those, uh, places in, in Lehigh Valley, uh, that were dirt roads. And we got to go up all these coal, these coal mountains and see all this cool stuff. And we're doing it on essentially road bikes, uh, road bikes with some those giant 25 CC tires. Do you remember those giant. Yeah, so I, I LULAC was actually founded on a, a gravel, or sorry, they can't, gravel. Yeah, they didn't exist yet. It was founded on a 25 CC touring bike. Uh, my indie fab touring bike is what I went out on because it had the most clearance, uh, to fit the biggest tires. And those tires, like I said at the time, were 25 c. And then of course, I, I had a cross, a cross bike and I'm like, oh, I could take this one out too. And, uh, and, and check it out on, on the cross bike. And that definitely helped, especially when disc brakes come in and, you know, a wide range of gearing and those sorts of things. But yeah, I've, I've done, I've done it all with the, the, the prospect. I'm like, this is the best thing ever. And now we and now we're out. Where, where we. [00:12:43] Craig Dalton: Yeah. Yeah. And that's kind of what I was getting at. You know, thinking about starting the event 11 years ago, you know, the equipment obviously wasn't there. What was the motivation to create the event and what was the type of terrain that you took the riders on in that first year? [00:13:02] Patrick Engleman: Uh, . The first, so the first year, uh, the, the motivation, I'll ask the fir the first part of your question. The motivat. Was, I, I love Northeastern Pennsylvania. I don't happen to live there, but like my, I still call it home if I stand going home. Almost all my friends now I'm going to Northeastern Pennsylvania. So to, to pitched into the Scranton area. So I love it so much there, but I, and I do, I go back and visit my, my, almost my entire family's there. Um, so I go there a lot and I love the outdoors. I've, I grew up in the outdoors and I just wanted people to come see it. Um, my friends here are, you know, they, they're suburban nights. They live around, around Philly and, you know, they're kind of used to that suburban lifestyle. And I was like, let me take 'em up to where I'm from. Cause I would tell 'em all these fantastical stories of the rides and the R roads and everything else. And I'm like, Invite my buddies, you know, like to come up here and go for a ride. Uh, and that's how we got Dave and Celine. You know, there, there were the, there were two of the first 18, uh, that came out and tried it. And then that first year, um, I initially built this to be almost like a spring classic. And because the spring classics happened around Easter, I did it for the first year, was on, on Palm Sunday. And Palm Sunday was near the end of March, and in northeastern Pennsylvania, it snows a bunch, uh, or at least it used to. And, uh, we had snow on the sides of the road and mud and everything else. Uh, and it was, it was chilly. It was a chilly, chilly day. And that course, Had a blend of road and, and gravel or dirt. Um, there's some single track in there. Uh, we start off the ride still to this day with, with the single track that I grew up on, uh, in my neighborhood. And then we go off onto some of those dirt roads and the, and the course has not changed dramatically. , but there were definitely some spots that were like, nah, we don't need that anymore. Or I found other roads from being out there and, and, and doing more exploring. Yeah. And other, and other riding. So, um, the course, there's some parts this, like I said, are, are still the same and that people expect to find, like we have, um, we have one waterfall or 33 miles. So we have, uh, so I, so those, those waterfalls are, are an important part of the ride and people expect to see them and expect to, to hear them. And so like that stuff has stayed the same. And this year for our, our 10th ride, we're actually gonna go back to a little bit of the first route in a couple places. Uh, so people can see where the first, like, first like one, two, or three years went, um, versus what it, what it is now. Plus it changes it up for, for people who just started the last couple. It's now gonna change up the course for them and kind of, uh, for me, bring a, a, you know, a nod back to the good old days. [00:15:31] Craig Dalton: Yeah. When you think back to those first few years, and you looked around the start line, what kind of bikes were people on? Was it a, was it road bikes, cross bikes, mountain bikes. [00:15:41] Patrick Engleman: Uh, definitely a blend. I mean, like I said, the time cross was huge and everyone raised cross and, and there were, there were a lot, a lot of folks were on cross bikes because they just didn't know what to expect. Um, but I, I'll shout out forever. My buddy Tim Wood showed up on a single speed road bike and said, is this okay? And I'm like, I don't think so, , but you could try it. And I thought he was joke, I thought he was joking. I thought he just had like an extra bike in his car and he brought it over to me thinking it was cause I warned everybody what was, what was gonna happen to them. And um, cuz lulac we'll probably get into a little more, but LULAC is 103 miles and almost two vertical mi, almost two vertical miles of climbing. Uh, so a single speeded road bike does, does not, uh, you know, a track bike in the city does not quite cut it. Um, but there were a few, most, most had curly bars that first year. I don't think there was any. There was one mountain biker. Um, but every else had some, at least some form of curly bars that were, looked more like abike than anything. And, um, that had, we have, we Go ahead. [00:16:34] Craig Dalton: I was gonna say, so that first year you brought at and a, your friends and convinced him to drive a couple hours from Philly to Experie. What you'd been talking to them about for, for many years, I presume. Yeah. Going forward to that second year, did it become a thing where there was a registration and, you know, more, a proper event in your mind at [00:16:52] Patrick Engleman: that point? Yeah, it ki it definitely, it, it necessitated a little bit. Like that first year I remember it saying to my mom, cause she was like, well, where's this thing gonna start? I'm like, I don't know. The park down the street and like, I'll get a porta potty and we'll be cool. And like where people could come to the house and change. And she was like, What, you know, like, and then luckily a, a brewery that was just starting, that was actually a long story short, but basically they were, they were just starting and this, we were their first event they ever did. And I called him like, Hey, can we do this? And the luckily, one of the co-founders used to put on Ride for the Roses in Texas and he was like, yeah, of course, no problem. And so the second year we're like, okay, we've got, we've got to go to Brewing Company, so we're good on that. Uh, we have all these things. So it's just kind of almost like started itself as an. Where like I don't have to worry about like putting a porta potty at the park down the shape of my mom's house. I could just go to this brewery that has the, some of the infrastructure that we need. Amazing. [00:17:45] Craig Dalton: Yeah. Amazing. So then what, what is, you know, if we talk, if you think about, um, the progression over the 11 years, what type of attendance numbers were you looking at and how did that change, like your stress level, the amount of work you had to put in and, and your enthusiasm one way or the other? [00:18:05] Patrick Engleman: Yeah, I mean, I'm still psyched about it. I mean, it's, it's, it's, some days I'm like, oh man, like, uh, this sometimes is, there's a little bit of a monkey on my back, but like, I'm still psyched every day that I get to do this. I'm like, this is, this is cool. You know, this is, this is a lot of fun. And, you know, it's, it's, um, you know, it's nice to hear people's stories every time, every time I run into people, they tell me stories about their rides and some of the stuff. But, um, the attendance numbers, I kept it limited because the infrastructure where I, where I'm from, and also this is put on by my family and. . And I don't, I I was listening to one of one of your podcasts with like this big professional, uh, situation and like I'm. I feel it's professional, but it definitely took a while to get there. And, uh, and I always relied on that. And also, yeah, I have a, a background in punk rock where like, like we didn't invite, not that we weren't inviting, is that it was DIY and we were trying to keep it as low, low profile as possible. And, you know, that's, that's okay until it starts selling out in a couple minutes. and, and so we kept it like three 50 or so for a wa for a few years, and then I bumped it up to like 500 people. Uh, and I think it was 19 is when I finally bumped it. I'm like, okay, we can take on a few more. I think I got this thing took me a little bit of like, okay, we got 300. This is easy. No problem. And then we bumped it. We bumped it at five and it was like, and then it poured rain. and was 40 degrees, but that's a whole, that's another story for another day. Um, yeah. So, so, so this year we're, we're up again, uh, looking. 6 57, like, uh, or so. Um, and we'll see kinda where, where we get to. So at over the years, it, it, the stress level of course changes, but you learn a lot and, you know, if you, you could, you learn and adapt as you go and, and you learn every year and you also find your other mentors. You know, I, I, I'm lucky enough to have, have mentors in this space, uh, that I'm very close with. Uh, , uh, Dave Pryor, of course I mentioned, and, and, uh, and, and some other folks, uh, Mike Koon, who puts, who now puts on grand, who put on, used to put on Sylvania Epic. Um, you know, so Mike and I are very, very close. So like there's a few, uh, folks that are just help, help out all the time, you know, with, with anything I can bounce off of them. So I very, very lucky to know some, some pretty incredible promoters. So that, but that stress level, I've just changed processes, you know, like I have more information on my website now and like this year with some of the stuff that we've got going on. Like I want to do more intro, like about like this kind of stuff, like the podcast like. Who are we? What are we? Because people hear about this name. Yeah. And it's promoted and their friends are doing it and they've heard, you know, it's been around and they're like, who the heck is this person? And I sometimes expect, everyone knows the whole story and people are like, yeah, I have no idea. You know, like last year and I went to the, the whole, the race hotel the next, the next morning. And I got breakfast with some friends and I saw some folks wearing a lulac a t-shirt. And I'm like, Hey, did you guys do the ride yesterday? And they're like, yeah. I'm like, well thanks a lot. That's really cool. And they were asking, they just started telling their story and I. adding to their, you know, adding on and telling them little bits. And then finally they go, who are you? And I was like, I'm, I'm, I'm Pat Engleman, I'm on the, I started the ride. And they're like, holy crap. Like, I didn't know, like that was you. And, and it was cool. But it was also I think, a failure on my point that like they didn't know who it was. And not that they need to know who I am, I really care less. It's that, the fact that I feel so personal to me that I, yeah, they should know at least who I am or I should have at least said hi. And thank you so. [00:21:22] Craig Dalton: I think it's, you know, it's so interesting as you were talking to me earlier, just saying, you know, um, how you brought this back to your hometown and it starts off on the single track you used to ride as a child, and it was really about showcasing the great terrain where you grew up to your new friends and you know, family that live couple hours away. That's such a, like, interesting origin story and I, I feel like for me, that helps connect me with an. To kind of know why you're putting it there. Yeah, which I, which I loved. I also, I do love some of the information you've got out in the FAQs and some of the way it's phrases phrased. I'm gonna read one for you. I am the best racer ever. I plan on winning this event. What do I get if I win? [00:22:09] Patrick Engleman: And the, the answer is, um, they get a hatchet with their name en engraved on it, and there's only two. First two people, the fir, they get that and everybody else, uh, they do get, I, I should have grabbed one. They do get a little finisher's medal and it's, I, I sometimes call it finisher's medal. Cause that's what people understand. And I, I basically call it like an accomplishment medal. And it's like you, it's just on the table when you come in and you check in, it's on the table and like, grab your medal if you want one. And really what it is, is did you start out and you wanna do a hundred? And you got out there and realized this is ridiculous, and I did and you did 80 and you're still psyched, grab your metal. Did you do the whole hundred and like, you feel great, grab your medal. Did you only make it 30? Cause you got a flat, you couldn't fix it. Now you don't want that medal cause you gotta come back next year. Don't, don't take it. And that's your thing. So, and that's really what it is. It's a, you know, challenge by choice and you know, do you want to go out there and do it? Great. And you want the metal, some people hang them up. It's really cool. I see cold displays of all the years. We, we have, it's just literally like a, a die cut me, uh, metal from a, a local fabricator. Uh, we do different colors every year and people have a whole like collection of 'em now. Uh, cause the first two years we actually had a, a jeweler, uh, the fir the first year I have one of them that's made a silver. Uh, the first finisher's medal, there were like 20 of them. Wow. And then, uh, the second one, we had a couple, we, we were doing the jeweler, uh, for a couple years with only 18, and then we would just get 'em out randomly. But now there's just so many people, it's hard, it's people also get angry, uh, if they don't get the, the, the fancy ones. So we noticed everyone gets their, the little. [00:23:37] Craig Dalton: So as you've taken that journey from 18 to three 50 now to 6, 6 50, you know, what kind of logistical challenges has that created for you? I'm always curious cause I, I know how much work it takes to put on an event. Yeah. So I'm curious to kind of extract a few of these details for any. Would be event organizers who are kind of thinking about this journey or who are on it on their own? Yeah. [00:24:01] Patrick Engleman: Um, I, I gotta tell you the, the logistical, the first thing I solved and the, uh, and I, I guess not, probably the first thing, all the biggest impact I feel that I solved was I got a storage locker . And I felt like such a, like a big deal. I finally got a storage locker cause it was all, all the stuff was stored in my mom's basement and in my parents' basement and like, Have to go up the stairs into downstairs and then turn the corner and it's like a little small in there for me. And man, that saved so much time to back up a sprinter and dump everything in and dump everything back out now. So that was huge. So would be event organizers, once you get to a certain point, spend the money, get it, get it. It's so much, so much, uh, it's, it's such a value to everyone that's involved that you can just go to the, go there, do inventory, do all the things you need to do, but logistics on the ride and, and, [00:24:47] Craig Dalton: okay. And. Pat one, one question. Do you, with your peers, and I know there's like more than a handful of events in PA and you mentioned being friends with a number of those event organizers, do you guys share any logistics issue? You know, do you share, like we all borrow a stage from one another or whatever you need? Yeah, [00:25:05] Patrick Engleman: anything is up progress. I mean, like we have, I I, I could ask any of them for anything and, and they, and they know the same for me. And, and that's, and that's for anybody. I mean, like, I have friends, uh, you know, I was. To your podcast the other day. People ask all the time, like, can I borrow a tent? Sure, no problem. Because I know I would've loved to add that tent. And it was a big ask, you know, like 10 years ago for me to get a tent for somebody. And now like they're just sitting there most of the year, you know, like, come, come borrow something. And um, so yeah, we share radios, uh, share those sorts of things. We're actually looking at, um, getting some of those like spot, not the spot trackers, but the, um, the more like, uh, like satellite phones and having a co and like starting. Grow a selection of those, uh, because I know we're not, we're not Northern California remote, but we're hills and valleys remote, where like you can't, yeah, you might be close to a city, but there's no, there's zero communication in some of these places. So, and as we go further out, the communication is a disaster. So we're, uh, and Omic and, and Dave and myself and a couple others, we've talked about like kind of starting to grow that, uh, infrastructure of those very expensive pieces of equipment to share and share. . [00:26:09] Craig Dalton: Yeah. Yeah. And I think before I interrupted you, you were gonna start talking about like the course and the impact that 600 riders has versus. [00:26:18] Patrick Engleman: 18. Yeah. So yeah, logistics, uh, literally went from the, the back, the, uh, the trunk of my dad's car, uh, to, and like the, you know, the, the, uh, tailgate of my, of my car, uh, to now logistics. The number one logistic issue is we have, is we at mile 54 on top of the, almost the highest point on the course, we have a full-blown taco stand. Uh, so you get to mile 54 ish, Cland giant hill. And there is tacos, uh, for you to, to take. And, um, this year Shram is sponsor is sponsoring that, uh, which is really cool to get them involved. Um, but they're, um, getting water there and getting. Food and all the, and then the trash home is always for me, it's like, oh yeah, we gotta take this stuff home. And finding those locations and finding cool folks who are willing to be like, yeah, sure. Just hang out in my front yard for the day. Uh, and we've, we've been very lucky to find those people who they want nothing in return. I've tried to bring them beer, you know, I've done all those things and they're like, oh yeah, cool. Thank you. You know, that's about it. That's all I want. Case, you know, I bring them case of your, and thank you. And that's all. And it's been awesome to find those people, but finding those people. Takes time, you know, and, and, and takes the guts to knock on a door in the middle of nowhere too. So , I am, I'm willing to do, I'm willing to do that, but I've definitely, uh, have been, you know, a little nervous dealing that once in a while. But that's what it takes. So I think the biggest thing is, is, um, , it's getting water and things out there. Plus, on our course we have a, uh, the Que River runs, uh, directly through the middle of it. So we only have two river crossings, uh, two bridges, uh, for the entire course. Uh, so if you're on one spot of the course, you've gotta get to the other and you've gotta get to a, a, a bridge to get there. So sometimes having. Support services on one half of the course, and they stay on the east side of the river and we go to the west side of the river and stuff like that. Um, and the last one I would say is, is, is course marking. And anyone out there who wants to do this become a great course marker. And I, I, I would give a shout out to Brian and Nate, uh, and, and, um, and so, and, and the, and the other folks who do monkey night fight. They helped me and made me think about approaching this at speed, making a turn and confirming your turn. Right. And so two ahead, one confirmer. Yeah. Is all, is the way we always go. And, and Mo I I, you can do this course without a computer and I get that question all the time. Like, I have a computer, how do I get around? Just look at the ground. You would, you have to try hard to get lost. People do. You've gotta try pretty, pretty hard, uh, to get lost. Yeah. If you just look at the, at the L Arrows and my directions is, are. Look at the arrows, and if you didn't find one, go back to the last one you saw and then follow 'em again because you, you can't get, you can't get lost out there. [00:29:02] Craig Dalton: So what's, what's our lost number for the last 11 years? Any lost riders out there? [00:29:07] Patrick Engleman: Yeah, we have, we have one, uh, one, he happens to be one of my best buddies, and, and he got, he kind of, he, he kind of bailed out a little early and I was like, go this way and do this thing. and, and a couple hours later he calls me. I'm like, where are you? He's like, I'm standing here. I got, I'm like, tell me what's around you tell me street names and everything else. And he's like, I got the, I said, look at the church across the street. You see the red door? Yeah. Pulled up your right hand and, and then follow that and you'll get, you'll get along the river and you'll be home in like half an hour, 10 minutes, you know, half an hour, 15 minutes, whatever. Four hours later he calls me. He's like, I'm like, where you at? He's like, I got back to the church somehow, . I said, which way did you go, ? He's like, I think I went left and you told me to go right. And, uh, so yeah, he's, he's one of the most, most legendary ones. But I, I have, uh, we've had a few, uh, the year that it rained, I, I, I sort of, I was, um, 2019 is legendary for the rain and the weather. Uh, we started off, when I said to the group, I said, oh, here's your Rube day. You know, here's the day you're gonna look like such a hard ass. You're gonna, you're gonna be George NC Capy covered in mud. This is the day you get to do that, and you get to, and then, uh, this was like sprinkling and like mid forties. And by mile 10 it. Low forties, high thirties and pouring. And uh, so we got to the first rest stop and, uh, some people were kept alive by some hot pizza. We moved out there and, and a couple propane heaters that we were able to get. Um, and then I, a lot of people on that day, uh, were great and they took, and I luckily had myself and a couple others who were like, this is the way home from here. Don't, don't deviate from that. And most people, , uh, mo most people did, didn't make it nice, but there's still some, you know, some folks who, uh, didn't quite, didn't quite make it. They may have made the left when I told 'em, make the right and then spent a long day out there in the cold. . [00:30:57] Craig Dalton: Quick aside, the last time I saw Celine was in Bentonville, Arkansas. Pre-writing the big sugar course, it poured with rain. It was similar, similarly cold. Yeah. And I remember we, we hit this brewery and there was a fire and she had a complete change of clothes. To continue on and my dumb ass had nothing. Mm-hmm. . So I had to pull the plug and take the broom wagon home cuz I was freezing and not prepared at [00:31:25] Patrick Engleman: all. Celine's a pro for a reason, and I hope, and I hope she hear, I hope she hears this. She's a pro for a reason and for lo for lots of them. She's, she's, you know, one of the strongest writers I think on the planet. Uh, hands down. I mean she against anybody at any age except for following a gps. She can't do that to save her life And she knows, we all know that. , but her and Dave and another friend of ours named Dave on that ride that was so cold and miserable, they went to a, a diner in the, in one of the small towns and sat and ate, ate a bunch of soup and hung out and just waited out and then looked at the weather app and I got a message and, uh, one of the Star Wars had just come out and Dave said, if we watch Star Wars in Tocan, and we were late, can you come pick us up? I was like, why watch, why are you watch Star Wars? She's like, well, if we watch Star Wars, the weather rain will be over . So there's no pro her day bar like that. Like, look at the weather app and look at the theater across the street and say, man, three hours of Silver Wars, we can fi we can finish this thing and that. And they, and they, and they totally could. Um, Celine is just a, I love it. I love it. Give more Celine love here for one more second. She is the only female winner of LULAC ever, meaning that she has won every year. She has tried to win. She has. So there's been zero other amazing first female finishers outside of ELE here. So come get it come. Amazing. She's, she's had some competitors, but usually, um, you know, that's, uh, that, that lasts for only a little while and it's just, you know, knowledge of the area and also her being who she is. [00:32:51] Craig Dalton: Yeah, yeah, yeah. I wanna get into the course a little bit, but one more question. Um, I just was curious about, you know, we hear, talk about the impact of these events on the community, and when you talk about 600 riders coming in, does the community there? Like, are you, are you talking to the local city council? Are you filling up the hotels? Is, is everybody stoked because you've got 600 plus, you know, partners and families coming into town and spending money in the community. How's it become a [00:33:20] Patrick Engleman: thing? Yeah, so, so I, I was smiling because this year, this year's the first year, not that it's, hasn't been, been a thing for years, like. The brewery loves it. The hotels, we sell the hotels all the time. Uh, sell out the state park for people want to camp, um, all those things. But I've kept it away from the community outside of like getting in the newspaper or getting on TV or whatever. Um, until this year and this year, uh, the town of Pitton, like where I grew up and, you know, near and dear to me, has done a lot of work. Uh, coming back, you know, we're a coal mining town that got smoked after coal mining left and, you know, had a, a tough time in the seventies and eighties and, and, and it's a part of the nineties and now it's coming back and it's like one of those places it looks like Bentonville because it's a small town that like all these new things are popping up every day and you're like, oh my God, they got a New Mexico place now they got like this, this little we get just got the other day. This. , uh, used to be a bank like kiosk, like for like a drive up, and it just became a tiny, um, cafe where it's now a drive up instead of the bank. It's not a drive up cafe. So like we're getting like this, this, this dope stuff in town. So I, I reached out to town and said, Hey, every year, for the last couple years, I bring like around a thousand people here town a year. You don't even know I exist. And they called me within an hour, and we've been working together since. And so this year, yeah, with the, um, the, the Downtown Piston partnership, um, the Saturday before the ride, uh, we're starting in downtown Piston for the first time ever. Uh, we've always started at, at a fire haul just outside of town. And, um, when I met with them, I'm like, yeah, the fire haul, the fire, haul the fire. I'm like, how do we start downtown? And, uh, so we're starting downtown for the first time. A little bit nervous with this, you know, it's, it's new for me, uh, but we're also doing an outdoors and, uh, an arts expo, uh, the day before, and we've never done that. I've always wanted everyone, something like that. And, uh, so working with town and like town recognizes the impact of, of cycling. And, and I always tell people my vision for my hometown is that it becomes a place like, like Bend, uh, Oregon, where it was an environment, you know, a town that. Ravaged by the industry and then came back in an environment. It's a place where everyone enjoys the environment and the economy is based on, on tourism and bringing people in to ride, to hunt, to atv, to ski, to do all the things they can do, uh, the place that we're from and Northeastern PA has literally, you can kayak. Canoe on the river. You can ski, you could hunt, you can ride ATV trails, you could do all sorts of different stuff up there. And there's no reason why we don't do that. And that's like a life mission for me is to get to make that economy up there. A tourism based economy where people are coming there, people are buying second homes and everything else, and people go to the Poconos and it's right there next to the Poconos. Like how can we get people to go there more and recreate on their weekends and recreate all the time and spend money in the town? I grew up. . [00:35:57] Craig Dalton: Yeah. That's amazing. I love that. Shifting gears a little bit into the course, I know you, you now have several different lengths of the course. Yep. The Hondo being the kind of the big Una, the primary one, but you, I presumably, you wanna be inclusive and give newer riders the opportunity to kind of get out there and experience a little bit of what it has to offer. Yeah. But for the purposes of this conversation, let's talk about the Hyundai. Like, what's the terrain like in there if from coming from outta state, and I don't, I've never put rubber on, on uh, trail in Pennsylvania, what do I need to know in my head? You have [00:36:32] Patrick Engleman: to know that you, you should ride the bike that you feel comfortable on. And we say that all the time. And we've had mountain bikes, we've had fat bikes, we had tandems, we've had everything. Um, and you can, you can ride LULAC on a road bike. I will say that over and over again. You can ride LULAC on a, on a road bike. It's hella uncomfortable to do so. But you could, um, I like. , big tires, hydro, hydraulic disc brakes, and lots of gears. And that's a good way for me to spend my day. But if you want to murder yourself on a 52 chain ring, uh, you have at it. I could care less , but, but I know how I enjoy my day. So, um, there's a mix of road, uh, a ro, a mix of road road and, and as we call 'em up, they're dirt roads or gravel roads. Um, and the paved parts of the roads are some of the. Abusive parts of the road. It's Northeastern Pennsylvania after the, after the thaw. And there are manhole covers the size, sorry. There are, there are potholes, the size of me. Uh, and they're everywhere. And, and they're, you know, the roads are not, are, it's a rural area and the roads are not necessarily well maintained. They do their best, but it's a really hard environment to, to maintain roads on. So I, uh, all, all the paved parts I try to explain to people. I, I did a video last year where, cause everyone was like, oh, it's, it's a road ride. It's a road ride. And I, and I rode one of the roads, put my camera down, and I was like, do you want, this is your road, just so we're clear. And it might look like a paved road on, on the map. And it, I will call it a paved road. But it's blown to pieces and like you've gotta be on it. Um, and the rest of it. So we have, uh, a very clay, uh, if you're on the, on the gravel scale, I think they did like a gravel, like a candy scale, like from like the tinies up to like a stop or whatever. Um, we're in the solidly in the, like the pea gravel. with clay underneath. Um, so it definitely gives their, like their lines, especially when it's wet. It's kind of cool cause you end up with like a train track and just follow the train track you could. Um, but it's definitely a bunch of clay with some p gravel kind of in there. Um, some rocks and roots. Um, the first section of single track, there's two sections of single track at the beginning. Um, and neither of them are anything that you would couldn't ride across by, on or couldn't. I mean, I grew up on, so they're nothing crazy. And they're also only. Two miles max of that whole section. So people always like, wanna pick a bike for that? And I'm like, you're better off running it if you're gonna, if you're so nervous about it. And we have, we have great photos of people carrying their bikes while other people are just bombing it, you know, so there's, there's a blend of that. And depending on the, on the weather, it could be a total mud Pitt, uh, or it dries a bone, you just fly through it. So it's, um, the whole, the whole course overall, I think you're a great, modern gravel bike is fantastic because like I said, it's. at the end when you're climbing the la those last couple hills, you're gonna want that larger chain ring. Outback. You're gonna really want that. And none of the, there's a couple parts on the road that you can move, you know, they use it for, uh, the locals use it for uh, time trial course. Um, so you can definitely move on it and it's rolling. But man, I love some, having me some gears cuz there's some big steep hills and people are like, what the heck did he do to us? So some why. Yeah, [00:39:33] Craig Dalton: I was looking at the, I was looking at the elevation course profile. On ride with G P s and it looks like, you know, within the first call it 10 miles, you start a pretty substantial climb. That's the sort of predominant feature of the beginning half of the course. But even after you crust that you're still doing a bunch of up and down, which is what my memory of Pennsylvania is all about. A lot of, a lot of up and downs. And then you, you kind of do dip down back. Similar elevation as the start, and then you've got another big climb, you know, in the 60 to 70 mile range that you still have to tackle. Before what looks like a ripping downhill, maybe the last 10 miles. [00:40:11] Patrick Engleman: Mm-hmm. . Yeah. The la the last 10 is fun. And then you get onto a, then you get onto the river and, and some people think that's gonna be the easiest part. We have the, the river levy, uh, trail that we use, and then that, and then that, that, that side of town. Um, but you get on that river and sometimes that wind is just blowing off the river and people get so disappointed because they're like, they're looking at their gps and they're like, man, that. Bit is totally flat and they think they're gonna fly. And then unfortunately, sometimes the, the wind is against them and they're having a tough time. But yeah, that last little bit is, is a nice, you rip down, uh, an old railroad bed, uh, that's, that's, you know, it's a, it's a trail now, so it's, it's been taken care of. Um, you do at , I think it might be the only ride around mile 87 89, you climb a set of, You have to climb a set of stairs to get on and there's a little bike bike roller next to it, but you gotta climb a set of stairs to get onto the last rail trail. Um, but yeah, we have tho those are, those are fun when people realize that they have to go up to the steps. It's like, what, are you kidding me? This is like mile 87 or so. Last rest stops over and now I've gotta climb a giant set of stairs. So, it happens. [00:41:12] Craig Dalton: And then when they get back to cross the finish line, what type of experience do you have waiting for [00:41:17] Patrick Engleman: them? Uh, welcome, welcome them all back, just being so happy they're home. Uh, and, and giving them all we can, uh, to show 'em how, how happy we are to see them back. And they, they turn in their, their timing chip, and, uh, then they're handed pizza and beer as fast as possible. Uh, and that's, that's what we, we've gone to. Pandemic kind of brought us to pizza. Uh, because post pandemic, like, like I said, it's my family and my family and friends and my family are getting. Uh, so I want to keep them as covid safe as possible. So we started, uh, with pizza from someone who used to babysit me when I was a kid. Uh, our, our, a friend of our family, uh, named Nora and she makes this amazing, like deep dish pizza and people love it. I mean, we, we used to do like a sit down dinner and that kind of changed. And then post covid, people love just like tailgating in the parking lot. Pizza. Pizza. Yeah. And it's really, it's kind of changed the vibe, which is cool. Like the, the tailgate vibe. People love. Cause we used to like come in and we'd sit and dinner and they'd just sit there and you're, you'd eat this giant pasta and all kinds of stuff my mom would make and people would bring in and then you'd just sit there the rest of the day, you know, like, what the heck has happened to me? Where now like the pizza and beer, uh, experience is a little bit more, uh, like a tailgate style, which is cool. People just hang out and tell stories and we encourage people to. Tell us all, all they can about the day. And, um, people filter in and out. They wait for their buddies. They, and they just have a good time. So it's definitely, yeah. So totally laid back. It's nothing, you know, like I've been to some of the, some of the biggest events there are. And it's not like you go here and you hang out here and this is your, here is your thing that we made 30,000 of. And here's the thing, you go and you walk away and you've never seen 'em again. It's like, No, like, I'm gonna bring you a beer over and we're gonna talk about what you just did. You know you're gonna share, you know, man, that ride was crazy. This thing was this, or whatever. It's just, just fun. [00:43:00] Craig Dalton: That's awesome. What, what is sort of the time range, like from first person to last person to complete the course? [00:43:06] Patrick Engleman: Um, man, it's tough cuz I think we the full, so here's, here's the, here's the deep dark secret of Luca. . It'd be much better if I just called the LULAC 83. Cause that's what a lot of people do. They won't tell you they did the 83 cuz there's a cutoff that they can do. So a lot of them do cut it off a little early when they get out there and they're like, this is just bonkers. Why am I still doing this ? And there's a, uh, there's a decision point where we have a, a, you may have seen some of the pictures on, on Instagram, just like it's a party. It's our unofficial rest stop. But it's our local trail group is like, Hey, do you really want to do this? Or would you like a shot? And you go that way downhill. And there's a lot of people that take that, take that shot and and turn that's a hard choice. And turn at 83 and, and, and go and go for home. Instead of doing the hundred, there's plenty to do. The hundred. So to, to tell you that answer. People start rolling in. So we don't, now we, with post covid, we've also gone to a rolling start, so you could start anytime between eight and 10. Um, so with that, it's a little bit tough to say, but on time on course we're probably looking at seven hours. Most people are. are around there, uh, for, for the hundred, so seven hours or so, up to like nine hours. Um, folks are out there. Uh, we've had people push it to the 10 hour mark. Um, my role is dark. Is dark. Just be in by dark. Uh, well, we usually have a pretty good beat on who's out there. By the end, we've, we've got tracking, uh, tracking technology, and then also lots of eyeballs all over the course and support. So we've got a pretty good eye on who's where. Um, but dark is our cutoff and we haven't had dark in a. So, which is, you know, knock on wood, we haven't had dark [00:44:40] Craig Dalton: Yeah. In a few years now. Yeah. It seems like riders are usually smart enough on a rolling start that if they feel like they're gonna be, have, uh, be a long time out there, they'll roll up on the earlier side rather than taking [00:44:49] Patrick Engleman: off at 10. That's me. I'm a, you know, like unpaid unpaved. This year I was psyched to finish to be a 12, have a 12 hour average. and I, I, we left early knowing where we cold and, but we knew we were gonna have his Max Max. I'd rather have those extra two hours of sunlight than sleep for that extra little bit because I, I would be nervous Yeah. The whole time if I didn't have it. Cause I'm not, I mean, I'm. I keep moving, you know, like plucking along a hundred miles or 12 miles an hour for the day isn't bad, but I, uh, but I'm not, you know, going 18, 20 all day. So I wanna make sure I have the maximum time. And I also see my friends at the end too, see my, see my Celine, uh, this year. Uh, speaking of her again, I got to drag her into the finish of unpaid, which was, we, uh, the unpaid finishes on a long, a long rail trail. And she knows from many of our rides that she just sits behind me and I'm a giant wind sail, and she was just, you know, cruising, cruising in behind me. So it was, it was a good. [00:45:40] Craig Dalton: That's great. Are you still in April for the event? [00:45:44] Patrick Engleman: Yep. April, April 23rd this year. Yeah. So we, we, [00:45:48] Craig Dalton: okay. And has, has, is registration opened already? [00:45:50] Patrick Engleman: Yep. Registration. Registration is open. I think there's like three or so, three or so hundred people in there right now. Um, and, um, actually, uh, tomorrow, uh, TREKK, uh, is our title sponsor for this year. And they're gonna start a pretty serious, uh, blitz on marketing for, uh, starting tomorrow. Uh, so that's, uh, they're gonna do some, some stuff with, um, You know, just, just marketing through their, their channels and also within their stores and stuff like that. So it's been, it's been cool to have a, have a partner like them come in. [00:46:21] Craig Dalton: Yeah. That's awesome. I think it's like a testament to the reputation that the event must have garnered over the last 11 years. That track would come in and, and, and wanna help you out. And, and you mentioned Ramer earlier, so it's great to. Here you're getting some industry support. Yeah. [00:46:34] Patrick Engleman: Yeah. It's, it's been great. People, people have been awesome for years. We've had, we've had a lot of great sponsors, uh, over the year and, and this year hearing from hearing from track was like, wait, who, who, who's this ? You know, like, do you have the right number? Uh, and, and know, and, but it, but it is, it's, it's definitely, it's, it's humbling. Uh, but also, but also kind of justifies all the work we've done over the years to, to get someone like, like track to, you know, get their eyeballs on, on our little, our little. [00:47:00] Craig Dalton: Yeah, for sure. Well, this was awesome, pat. I really enjoyed the conversation. I always enjoyed thinking about Pennsylvania as a cycling destination cuz as I said, I had some, so many great experiences there when I was younger. Yeah. On the mountain bike and I, I recognized. What a beautiful, and underappreciated is not the right word, but it's such a, it's such a big state with a lot of really cool outdoor activities that D doesn't get the shine like, you know, Colorado might, for example, and it's such a great area [00:47:31] Patrick Engleman: and so , you're allowed to say California. It's okay. We know [00:47:35] Craig Dalton: we get a little bit of shine, we [00:47:36] Patrick Engleman: get a little bit of. Yeah, the, uh, but I, I appreciate, I appreciate you saying that because it's true. And, and I love, I love Colorado. I love California, Utah, Idaho, all those places. And they get, they've got the big mountains and it's mag, it's the, the majesty. And, you know, you look out on this vista and, you know, Pennsylvania's got these tough little coal towns and they're just surrounded by the same majesty. You've gotta look differently. Right. And that's, and that's really what it is, is like I go to Colorado. I'm, I'm in total awe. I'm, I'm like, I sh shivers when I see it, or Northern California or Idaho. And I'm like, oh my God. , but then I also do the same thing back home, you know? And, and, and it is possible. So I, I really, I'm really happy. You, you, you mentioned that like the East coast, east coast does have some cool stuff, you know, you don't have to necessarily be out west all the time. [00:48:19] Craig Dalton: You know, and I just love that, that life goal of yours to just shine a little bit of light on this area and perhaps play a little part in the community, understanding the value of the outdoors, and when you throw up that outdoor flag and do things like you're doing with this event. You start to get that draw and you get the people from Boston, you get the people from DC coming in there and it becomes sort of a habitual part of where they want a vacation and where they wanna spend money. Yeah. Which is so important to these communities that, you know, their, their earlier livelihoods are not available [00:48:50] Patrick Engleman: anymore. Absolutely. Yeah, absolutely. And and I, and we have it in states. We have so much, so much land and so many places to go, so I'm really excited to see what happens. Yeah. And I may not see it all, but I'm, I'm happy to see it, to, to start to hopefully start this off and help the other people who also up there are working on this. [00:49:05] Craig Dalton: Yeah, I love it. I love it. Well, I'll make sure all the details are in the show notes so people know how to find you. Hopefully this will serve as a little bit of a guide to athletes who are curious about your origin story and make sure they recognize you and give you the high five you deserve for all this [00:49:19] Patrick Engleman: effort. Thanks Craig. And I'm, I'm, I'm excited to have a, a more of a, a national audience on this. I know we, we've been on some local podcasts and, uh, but it's nice to, you know, you, you're doing this for not just California, not just not just the big guys, you know, and, and I love the big guys and I, I love hearing their stories and uh, and also learning a lot from all of them. And that's also funny to hear them like, oh yeah, we've been doing this for 10 years, or We've doing this for seven years, or whatever. I'm. Man, you know, like I've been doing this for a long time, but I've also kept it quiet kind of on, on purpose to a certain extent. Yeah. So, um, yeah, [00:49:49] Craig Dalton: you know, I mean, that's the way you get sort of, you talk about authentic growth and I think that's where, that's where these really well run, well thought out events come from where you're not just like, , I want to go big from day one. I wanna have a thousand person event when you have no business and our, our understanding on how to pull that off. Mm-hmm. , I, I, I mean I, from the outside, I feel like you've done it right, pat, and kudos to you for that. I appreciate [00:50:11] Patrick Engleman: it, Craig. Thank you so much. Yeah. Yeah. Have a good evening. You too. Thank you. That's going to do it for this week's edition of the gravel ride podcast. Big, thanks to Patrick for joining the show. And talking about this great event out there in Pennsylvania. Also a shout out to our friends at athletic greens and One for their support of the show. If you're interested in checking out their product, simply visit athletic greens.com/the gravel ride. And you'll get that free. One-year Sunpro. Free one-year supply of vitamin D and five free travel packs. If you're interested in connecting with me, please join the ridership. That's www.theridership.com. Or if you're able to support the show, please visit buy me a coffee.com/ I'll ride. Or leave us ratings and reviews. Reviews are surprisingly important in podcast discovery. So it helps me connect with other gravel cyclists from around the world. Until next time here's to finding some dirt under your wheels      

Kevin Perrott's thesis on aging and its impact on the organization Open Cures. The episode also delves into the use of multi-omic data and the importance of biobank donations and giving blood. The conversation touches on the potential for colleges and students to be a focus for Open Cures and highlights bottlenecks that the organization … Kevin Perrott: Longevity, Aubrey De Grey, Michael Levin, OpenCures, Multi Omic Data, AI, ML – 152 Read More »

In this episode of The Oculofacial Podcast, we kick off our series on Practice Management by talking about risk, and how to set up your practice to serve the needs of your patients. Dr. Kian Eftekhari interviews Dr. Tamara Fountain - Professor at Rush University, Former ASOPRS President, Former AAO President and Former Board Member of the Ophthalmic Mutual Insurance Company (OMIC) – to discuss pearls for patient safety, minimizing risk and being confident and frank with your patients about the outcomes of surgery. Tune in to hear her refined approach to patient care after 25 years of practicing oculofacial plastic and reconstructive surgery. If you're an ASOPRS member surgeon or trainee and are interested in hosting a podcast episode, please submit your idea by visiting: asoprs.memberclicks.net/podcast

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.14.512250v1?rss=1 Authors: Zhu, K., Bendl, J., Rahman, S., Vicari, J. M., Coleman, C., Clarence, T., Latouche, O., Tsankova, N. M., Li, A., Brennand, K. J., Lee, D., Yuan, G., Fullard, J. F., Roussos, P. Abstract: The cellular complexity of the human brain is established via dynamic changes in gene expression throughout development that is mediated, in part, by the spatiotemporal activity of cis-regulatory elements. We simultaneously profiled gene expression and chromatin accessibility in 45,549 cortical nuclei across 6 broad developmental time-points from fetus to adult. We identified cell-type specific domains in which chromatin accessibility is highly correlated with gene expression. Differentiation pseudotime trajectory analysis indicates that chromatin accessibility at cis-regulatory elements precedes transcription and that dynamic changes in chromatin structure play a critical role in neuronal lineage commitment. In addition, we mapped cell-type and temporally specific genetic loci implicated in neuropsychiatric traits, including schizophrenia and bipolar disorder. Together, our results describe the complex regulation of cell composition at critical stages in lineage determination, serve as a developmental blueprint of the human brain and shed light on the impact of spatiotemporal alterations in gene expression on neuropsychiatric disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.30.510346v1?rss=1 Authors: Chiou, K. L., Huang, X., Bohlen, M. O., Tremblay, S., O'Day, D. R., Spurrell, C. H., Gogate, A. A., Zintel, T. M., Cayo Biobank Research Unit,, Andrews, M. G., Martinez, M. I., Starita, L. M., Montague, M. J., Platt, M. L., Shendure, J., Snyder-Mackler, N. Abstract: Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. Altogether, we profiled 2.58M transcriptomes and 1.59M epigenomes from single nuclei sampled from 30 regions across the adult brain. Cell composition differed extensively across the brain, revealing cellular signatures of region-specific functions. We also identified 1.19M candidate regulatory elements, many novel, allowing us to explore the landscape of cis-regulatory grammar and neurological disease risk in a cell-type- specific manner. Together, this multi-omic atlas provides an open resource for investigating the evolution of the human brain and identifying novel targets for disease interventions. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Sección semanal que ha permanecido 34 años en antena, con Luis Morcillo, director de la OMIC

Ventiquattresima puntata della terza stagione della rubrica, nel canale spreaker J-TACTICS, dedicata alle women ed alle giovanili della Juventus, J-WORLD.L'atteso big match della sedicesima giornata di Serie A Femminile finisce in parità, con il distacco di tre punti in favore delle Juventus Women che rimane invariato.A Vinovo le bianconere e la Roma danno vita a una gara ad alta intensità: padrone di casa in vantaggio nel primo tempo con l'autorete di Soffia, giallorosse in gol nella ripresa con Làzaro per il definitivo 1-1.La corsa scudetto resta aperta, con il Sassuolo pronto a inserirsi e all'orizzonte l'impegno di Coppa Italia contro il Milan.Un'altra prova di carattere permette alla Juventus Under23 di tornare dalla trasferta di Sesto San Giovanni con tre punti in più in classifica.Contro la Pro Sesto decide un gol nel finale di Koni De Winter, al rientro post infortunio.Un successo che proietta i ragazzi di Mister Zauli a quota 46 punti, ampiamente all'interno della griglia play-off.Questo è il sesto risultato utile consecutivo dei bianconeri che hanno ottenuto in queste ultime gare quattro vittorie e due pareggi.A pochi giorni dalla storica vittoria in Youth League contro l'AZ Alkmaar non era facile trovare le giuste energie fisiche e mentali per affrontare una gara molto complicata come quella contro la Sampdoria, ma la Juventus Under19 è uscita da Bogliasco con tre punti pesantissimi.Al Centro Sportivo “3 Campanili” i bianconeri vincono 4-1 al termine di una prestazione matura, da grande squadra.Dopo l'1-1 della prima frazione, che ha visto Chibozo aprire le marcature prima del pareggio blucerchiato firmato da Bontempi, nella seconda metà della ripresa la gara è stata definitivamente chiusa nell'arco di cinque minuti con il gol di Mulazzi e la doppietta di Turicchia.Una Juventus Under19 sfortunata esce senza punti dalla trasferta emiliana contro il Bologna.A Casteldebole il match tra bianconeri e rossoblù si chiude con la vittoria per 1-0 dei padroni di casa grazie alla rete al 2' di Paananen. La squadra di Mister Bonatti prova a più riprese a recuperare lo svantaggio, ma la parata di Bagnolini sul calcio di rigore di Iling e la traversa di Omic su calcio di punizione, oltre a diverse occasioni non capitalizzate, non le permettono di trovare il pareggio.Bel successo anche per l'Under17 di Mister Pedone che esce dalla trasferta ligure contro la Sampdoria con tre punti e senza aver subìto gol.Al Centro Sportivo "3 Campanili" i bianconeri vincono 2-0 grazie alle reti di Anghelè e Vacca, entrambe messe a segno nella prima frazione.Con questa vittoria i bianconeri scavalcano i blucerchiati e salgono al terzo posto in graduatoria.Pokerissimo per l'Under16 di Mister Panzanaro, in trasferta, nel derby contro il Torino.L'avvio di gara dei bianconeri è strepitoso con tre gol, di Nobile, Biliboc e Pisano, nei primi tredici minuti di gara.I granata provano a rientrare in partita con il gol di Rossi, ma nella ripresa Finocchiaro (dalla panchina) e Scarpetta chiudono definitivamente i giochi sul 5-1.Juve prima in classifica a quota 32 punti (il Monza, secondo, è a quota 27 punti).Finisce 1-1 l'altro derby del week-end tra l'Under15 di Mister Benesperi e quella del Torino.Al gol del vantaggio bianconero firmato da Verde risponde, sempre nella prima frazione, Casadei.Juve seconda in graduatoria a due lunghezze dal Cagliari primo.Un successo netto quello delle Under19 bianconere di Coach Piccini che, tra le mura amiche, superano 5-1 le pari età della Pro Sesto. Arcangeli e Ferrari aprono le marcature e permettono alla Primavera bianconera di chiudere sul 2-0 la prima frazione. In avvio di ripresa il gol della Pro Sesto con Citelli riapre il match solo per qualche minuto prima che le reti di Pfattner, di Ferrari (doppietta per lei) e di Magliano che non giocava da maggio per la rottura del legamento crociato.Con questi tre punti le bianconere salgono a quota 37, sempre in vetta alla classifica.Altra vittoria seppur di misura in ambito femminile.Le giovani bianconere dell'Under17 femminile sconfiggono per 1-0 le pari età del Genoa nel match valido per il campionato nazionale.Sonora sconfitta invece, per le ragazze dell'Under17 femminile che perdono 4-1 dalle pari età dello Spazio Talent nel match valido per il campionato giovanissimi Prov. Maschile.Infine, l'under15 femminile sconfigge con un perentorio 5-0 le ragazze del Freedom, nel match valido per il campionato nazionale.Non mancherà poi uno sguardo ai prossimi impegni delle women e delle giovanili:Milan-Juventus Women,Coppa Italia femminile,Gara di Andata di semifinale,Sabato 12 marzo, ore 14.30,“Centro sportivo Vismara”-Milano.Juventus-Südtirol Under23,Domenica 13 marzo, ore 14.30,"Stadio Giuseppe Moccagatta" -Alessandria.Juve-Hellas Verona Under19,Sabato 12 marzo, ore 10.Juve-Liverpool Under19,(Uefa Youth League)Martedì 15 marzo, ore 16.Juve-Sassuolo Under17,Domenica 13 marzo, ore 15.30.Juve-Como Under16,Domenica 13 marzo, ore 13.15.Juve-Como Under15,Domenica 13 marzo, ore 11.30.Tavagnacco-Juve Under19 femm.,Domenica 13 marzo, ore 15.Juve-Boys Calcio Under17 femm.,(Campionato nazionale).Juve-Lesna Gold Under17 femm.,(Campionato giovanissimi Prov. Maschile).Femm. Juventus-Juventus Under15 femm.,Sabato 12 marzo, ore 17.Anche quest'anno sarà nostra guida nel mondo Juve, il sempre competente e preciso amico Roberto Loforte, Fuori rosa TV.

Son dakika... Sağlık Bakanlığı yeni tabloyu paylaştı. Buna göre Türkiye'de son 24 saatte 32 bin 176 kişinin testi pozitif çıktı, 184 kişi ise yaşamını yitirdi. Sağlık Bakanı Koca, "Vaka sayılarını 20 bin düzeyine indirmek ciddi bir başarıydı. Omic...

"Learning to Loath GMOs": A Critical Response to the New York Times   Richard Gale and Gary Null PhD Progressive Radio Network, July 27, 2021   In its July 19th issue, the New York Times Magazine published a brilliant piece of twisted pseudo-scientific propaganda. The essay, entitled “Learning to Love GMOs,” is truly stunning. Its author, journalist Jennifer Kahn, takes readers who would have little to no understanding of genetic engineering and genetically modified organisms (GMO) through a fictional labyrinth of out-dated and conflated GMO similitudes to an end point where readers might believe GMOs are really cool and there is nothing to be frantically worried about.    Kahn spins the story of Cathie Martin's research to develop a genetically engineered purple tomato high in the anti-oxidant anthocyacin as the work of a solo humanitarian to improve consumers' health by providing nutrient-rich GMO produce. What is missing from Kahn's equation is that the research was conducted at one of the world's oldest and most prestigious independent centers for plant science, the Johns Innes Centre (JIC) in the UK. The Centre, which is registered as a charity, lists over 500 employees and is funded by some of the largest proponents of genetic-modified plants, including the Bill and Melinda Gates Foundation and the Biotechnology and Biological Sciences Research Council. JIC's website includes purple tomatoes as one of its projects that combines “transcription factors, biosynthetic genes and iRNA [interference RNA] with the availability of natural tomato mutants.”  iRNA, or Post-Transcriptional Gene Slicing, is a method to silence certain genes the researchers desire to curtail their expression.     The Times article makes an effort to advance the flawed agro-chemical mantra of “substantial equivalence” without citing the term. The early acceptance of GMOs was largely based upon the unproven hypothesis of “substantial equivalence.” The USDA's adoption of this concept during Bill Clinton's first term in the White House gave GM seed companies a free pass to avoid submitting trial evidence to prove the environmental and health safety of genetically modified crops. Since the ruling claims that GMOs are fundamentally identical genetically to their natural counterparts, no compliance of safety regulations should necessarily apply. Therefore Big Ag firms did not have to worry over strict regulatory hurdles, which otherwise apply to other products such as pharmaceutical drugs, processed foods, pesticides, cosmetics and chemical additives.    However, during the past decade a flurry of research has shown that the “substantial equivalence” hypothesis is patently false. Alexandria University in Egypt, the Permaculture Research Institute and the Norwegian Center for Biosafety each found genetically modified crops to be fundamentally different. In addition, studies have confirmed that nutrient levels in traditional, organically raised grown crops are substantially higher than GM varieties. New technological methods to create concise profiles of a food's molecular composition, notably “omics,” were not available in the early 1990s when Clinton wore the mantle as America's first biotech president. Omic technology destroyed the Big Ag's industry's arguments to support the lie about substantial equivalence. For example, Kings College London published a study in Scientific Reports of Nature revealing unquestionable genetic consequences between GMO Roundup and non-GMO corn. The differences include changes in 117 proteins and 91 metabolites.[1]   Despite “substantial equivalence” having been debunked, the erroneous hypothesis continues to linger in pro-GMO propaganda. However, in Kahn's recent essay, she attempts to shift attention away from the early generation of GMOs, which were engineered solely to sell more toxic pesticides, and emphasize GMO's potential for increasing nutritional health and to advance medicine. In order to add a bit of balance, Kahn quotes James Madison University professor Alan Levinovitz who accurately described one fundamental criticism, among many others, against GMOs. “With genetic engineering there's a feeling that we're mucking about with the essential building blocks of reality,” Levinovitz stated. “We may feel OK about rearranging genes, the way nature does, but we're not comfortable mixing them up between creatures.”     But most disturbing is Kahn's failure to make any mention o the trail of environmental disasters and disease risks due to consuming genetically modified foods. She completely whitewashes the matter; she prefers we may forget that Monsanto's soy and corn, which now represent the majority of these crops grown in the US, was developed solely to allow farmers to spray highly toxic pesticides without injuring the crops. These crops contain notable concentrations of the pesticides that then find their way into numerous consumer food products including baby foods. Nor should we forget that Round-Up grown foods may be destroying people's microbiome.  Last year, researchers at the University of Turku in Finland reported a “conservative estimate that approximately 54% of organisms in our microbiome are “potentially sensitive” to glyphosate. Despite her pro-GMO advocacy, if Kahn's conscience had led her to take a moral high road, she could have at least apologized on Monsanto's behalf for the trail of death and disease the company's glyphosate has left in its wake. The company has yet to atone despite losing three trials with $2.4 billion fines, repeated appeal losses, and being ordered to pay $10.5 billion in settlements. To date Monsanto's glyphosate poisoning has been identified with the suppression of essential gut enzymes and amino acid synthesis, gluten intolerance, disruption of manganese pathways, neurological disease, cancer, amyloidosis and autoimmune disease. Her New York Times article would have better served the improvement of public health as a warning rather than an applause to appease companies such as Bayer/Monsanto and Syngenta. And shame on the New York Times' editors for permitting such biased misinformation to find its way into print.    Kahn is eager to cite findings showing GMO benefits without indicating her sources. She tells us that environmental groups have “quietly walked back their opposition as evidence has mounted that GMOs are both safe to eat and not inherently bad for the environment.” Kahn doesn't mention who these groups might be. She reframes the Philippine story of the destruction of genetically engineered Golden Rice; yet around that time even the pro-industry magazine Forbes published an article questioning Golden Rice's viability and noting that its benefits are only based upon unfounded hypotheses. As for its risks to health, GM Watch in the UK points out the work conducted by David Schubert at the Salk Institute that the rice might potentially generate Vitamin A derivatives that could “damage human fetuses and cause birth defects.”   Kahn, who should be acknowledged as a highly respected science journalist and teaches journalism at the University of California's Berkeley campus, happens to be a contributing author for the Genetic Literacy Project (GLP) at the University of California at Davis, a public relations operation sponsored by the agro-chemical industry.  Monsanto/Bayer, Syngenta and DuPont are among GLP's industry partners.  It is one of the most frequently quoted sources of cherry-picked information by pro-GMO advocates and journalists. In our opinion, it is perhaps one of the most financially compromised and scientifically illiterate organizations, founded and funded to disseminate pro-GMO propaganda in order to prop up public support for GMOs and genetic engineering in general. In effect, some universities now act as private industry's lobbyists. This becomes a greater scandal when the university is a public institution receiving public funding.  GLP and its east coast partner, Cornell University's Alliance for Science, largely funded by the Bill and Melinda Gates Foundation, serve as the GMO industry's clearing houses for public relations to spin science into advertising, propaganda and character assassination of GM opponents.   The Genetic Literacy Project is a key collaborator with another food industry front organization, the American Council on Science and Health (ACSH). ACSH has nothing to do with actual health science. It has been described by the independent corporate financial watchdog organization Sourcewatch as a thinly veiled corporate front that holds “a generally apologetic stance regarding virtually every other health and environmental hazard produced by modern industry, accepting corporate funding from Coca-Cola, Syngenta, Proctor Gamble, Kellogg, General Mills, Pepsico, and the American Beverage Association, among others.” ACSH also favors toxic pesticides, the use of biphenol A in products, cigarettes and hydrofracking.  It is closely aligned with pseudo-medical front organizations that criticize alternative and natural health modalities, such as Quackwatch and the Science Based Medicine network.    GLP sources a couple thousand corporate-friendly studies favoring GMO safety.  One review of over 1,700 studies, known as the Nicolia Review, for a time was the most cited source making the broadest claims for GMO safety.  However subsequent independent and unbiased reviews of Nicolia's analysis concluded that many of these studies were tangential at best and barely took notice of anything related to crop genetic engineering or GMOs. Many studies are completely irrelevant from a value-added perspective because they have nothing to do with GMO safety. Furthermore, other studies in Nicolia's collection conclude the exact opposite of their intention and give further credibility to GMOs environmental and animal and human health risks. When Nicolia published his review, he intentionally omitted and ignored scientifically sound research that directly investigated GMO safety and found convincing evidence to issue warnings.  For example, one peer-reviewed publication by over 300 independent scientists declared that there is no scientific consensus that GM crops and food are safe.  Not surprisingly, there is no mention of this study in the Nicolia Review.   It is no secret that Monsanto and Big Ag have significant influence over UC-Davis's agricultural department and divisions.  The bogus economic studies trumped up by the Big Ag cartel to defeat California's GMO labeling bill Prop 37 were performed at UC-Davis and then publicized through the GLP. Gary Ruskin, who has been filing Freedom of Information Act requests, has publicly expressed deep concerns that UC Davis is acting as a financial conduit for private corporations and interests to develop and launch PR attacks against academics, professors, activists and other institutions who oppose those same corporate interests.     For GMO opponents, the name Mark Lynas, may send shivers down the spine. As soon as any journalist or researcher mentions Lynas' name approvingly, one can be certain which camp the author represents.  You can be assured you will be reading words on dirty laundry washed in even dirtier water. Therefore when Kahn quotes Lynas as if he were an unbiased authority about GMOs, we know we have boarded the wrong train and will reach a destination of distorted scientific facts and self-righteous corporate praise.    The public watchdog group US Right to Know describes Lynas as “a former journalist turned promotional advocate for genetically engineered foods and pesticides who makes inaccurate claims about those products from his perch at the Gates Foundation-funded Cornell Alliance for Science (CAS).” Lynas has accused those who would inform the public about Round-Up's carcinogenic properties as conducting a “witch hunt” by “anti-Monsanto activists” who “abused science.”  Lynas has denied his role as a shill for Big Ag. However, a decade ago, The Guardian acquired a private memo from the pro-biotechnology organization EuropaBio about its initiative to recruit “ambassadors” to preach the GMO gospel. Mark Lynas was specifically named in the document alongside then UN Secretary General Kofi Annan as a prime candidate to pressure European agencies who were skeptical about GMO claims, promises and health and environmental risks. In short, Lynas has been one of Big Ag's most invaluable foot soldiers for over a dozen years.    Similar to the Genetic Literacy Project, the Cornell Alliance for Science does not conduct any agricultural research; yet its tentacles to attack GMO opponents are far reaching in the media. CAS was launched in 2014 after the Bill and Melinda Gates Foundation granted the alliance $5.6 million in start-up monies. The public relations Alliance makes the unfounded claim to represent “balanced” research about genetic engineered products.  One of its missions is to influence the next generation of agricultural scientists to embrace GMO science. For CAS, as for Bill Gates, GMOs are the only food solution for Africa's future. Five years ago, organic New York farmers mobilized to pressure the Trustees of Cornell University to evict CAS from the campus and halt its influence over the school's prestigious College of Agriculture and Life Sciences.   One argument Kahn wants us to buy into is that there were mistakes made during the early roll out of GMOs in the 1990s. But, somehow, mysteriously and without any solid evidence, we are supposed to believe that these same companies now engineering new generations of crops have learned their lessons. All that has really changed has been the genetic technology for altering plant genomes. The same mind-set that only technology and the quest for food dominance remain. After hundreds of thousands of dollars were flushed away during a genetically modified wheat project, a retired professor of plant agriculture at the University of Guelph in Canada remarked:   "We – scientists and the public – are so malleable and gullible (or is it because researchers and research administrators are just desperate for money?), that we swallow and become promoters of the mantra that GM is somehow going to feed the world: by resolving the monumental threat of burnt toast? Or browning in cut apples? Or flower color in carnations? Really? For shame. Let's be honest. The one and only reason these people, corporations, and governments are funding this sorry use of [lab] bench space is because it may yield a proprietary product."   Following Lynas' lead, Kahn wants us to believe that genes exchanged between different plants is common in nature and therefore manipulating genes between species with genetic engineering tools, such as CRISPR, should not worry us. Yes, plants have acquired genes from other organisms in the past – the far distant past – according to the Union of Concerned Scientists. However, it is so exceedingly rare that these should be regarded as anomalies without any correlation whatsoever to the millions of different genes available to bio-engineer new plant organisms. This has been one of Lynas' pet arguments on his bully pulpit since turning traitor on his former Greenpeace activists and joining Monsanto's legions.    It may also be noted that Jennifer Kahn is an active participant in CRISPRcon, a forum dedicated to “the future of CRISPR and gene editing technology applications in agriculture, health, conservation and more.” Among the organization's supporters are Bayer, the Innovative Genomics Institute, Cornell Alliance for Science, Corteva Agriscience and the United Soybean Board.  A mission noted on its website is expressed in one of its mottos, “The public doesn't trust GMOs. Will it trust CRISPR?” This is a public relations pitch that permeates her Times article.    It is important for independent investigators and researchers to identify and publicize the background of cloaked public relations shills posing as unbiased journalists in mainstream news sources. Kahn's New York Times piece is an example of a propaganda effort without credibility; it is an attempt to disingenuously manipulate the narrative so more Americans will love GMOs. In the wake of the agrichemical industry's efforts to bolster favorable images of GMOs and more recently CRISPR editing technologies, the mainstream media willingly rolls out a red carpet. No equal publishing space is awarded to the scientific critics of genetic engineering who uncover the flaws in the industry's public research. Consequently, journalists such as Mark Lynas and Jennifer Kahn are the norm rather than exception. Today the lesson is clear that money, power and influence sustain the lies and deceit of private industry.  Take on any cause critical of GMOs and agro-chemical agriculture, and Big Ag will come after you. Kahn is seemingly just one of many other journalists the GLP and Cornell Alliance can turn towards to advance genetic engineering's mythologies.    Seven years ago, 70 percent of Americans, according to a Consumer Reports National Research Center survey, did not want genetically modified organisms in their food. In 2018, the Pew Research Center reported that only five percent of Americans said GM foods were better for one's health – which about makes up the number of people who are in one way or another invested in the agrichemical industry. Still over half believe they endanger health. Yet too much has been invested into agro-biotechnology to expect GMOS to disappear at any time. As the public increasingly turns away from genetically modified organisms in their produce, we will expect new volleys of industry propaganda like that penned by Jennifer Kahn to dangle new carrots. For Kahn, one of these rotten carrots is to improve nutritional content. Yet, similar to the Golden Rice, this will need to be proven beyond being an infomercial. We can also expect to hear ever wilder and more irrational claims about how GMO-based agriculture might reduce CO2 greenhouse pollution and save humanity. And we expect much of this PR campaign to be backed by the World Economic Forum's full-throttle Great Reset invasion. In other words, out of desperation to reach global food dominance, the agro-chemical industry backed by western governments will be declaring a full food war against the peoples of the world.  It is time for us to unlearn any illusory attachment we might have to Big Agriculture and learn to loath GMOs.

Education: Ph.D., Animal Sciences, University of Illinois, 2014 MSc., Biotechnology, National University of Colombia, 2011 BSc., Animal Sciences, National University of Colombia, 2003 Research Interests: Our lab studies the factors that shape the composition and function of the microbiome associated to animals and humans. To that end, we apply a system-level view of microbes and host, using meta-OMIC techniques (metagenomics, metabolomics, transcriptomics), along with bioinformatic, machine learning and statistical tools. This approach is used to understand how the microbiome interacts with the host, influencing host nutrition, health and evolution. *This podcast is operated by Swine Impact, a Swine it Company.