Podcast appearances and mentions of David A Sinclair

Nghe trọn sách nói Tuổi Thọ - Tại Sao Chúng Ta Già Đi Và Có Thực Sự Phải Như Vậy Không? trên ứng dụng Fonos: https://fonos.link/podcast-tvsn --Về Fonos:Fonos là Ứng dụng âm thanh số - Với hơn 13.000 nội dung gồm Sách nói có bản quyền, PodCourse, Podcast, Ebook, Tóm tắt sách, Thiền định, Truyện ngủ, Nhạc chủ đề, Truyện thiếu nhi. Bạn có thể nghe miễn phí chương 1 của tất cả sách nói trên Fonos. Tải app để trải nghiệm ngay!--Ta sẽ làm gì nếu được sống thêm 20 năm? 50 năm? Hoặc thậm chí nhiều hơn?Từ lâu, lão hóa đã được xem là quy luật tất yếu của con người. Nhưng sẽ như thế nào nếu mọi điều ta từng được dạy về lão hóa đều sai? Với những nghiên cứu cũng như vốn kiến thức của mình, Tiến sĩ David A. Sinclair sẽ mang đến một góc nhìn táo bạo, thách thức mọi quan điểm cố hữu về tuổi tác, sức khỏe cũng như vận mệnh con người."Lão hóa là một căn bệnh và căn bệnh đó có thể chữa được." - Cuốn sách sẽ thay đổi hoàn toàn cách nhìn nhận của bạn về nguyên nhân lão hóa, chứng minh rằng mỗi người đều có khả năng làm chậm hay thậm chí đảo ngược quá trình này, đồng thời chia sẻ phương pháp giá trị nhằm kéo dài thời gian sống mạnh khỏe và minh mẫn hơn.--Tìm hiểu thêm về Fonos: https://fonos.vn/Theo dõi Facebook Fonos: https://www.facebook.com/fonosvietnam/

Today I have a special episode with Marc Bernegger. We are discussing an event that I am going to be speaking at, The Longevity Investors Conference later this month in Switzerland! Other incredible speakers will be: David A. Sinclair, A.O., Ph.D. Dr. Nir Barzilai, MD Dr. Aubrey de Grey Bryan Johnson Dr. David Furman + so many more! About Longevity Investors Conference ​ ​Longevity Investors Conference is the world's most private investor conference in the longevity space.  The main aim of the event is to bring together the world's top longevity key opinion leaders, institutional and private investors, wealthy private investors, family offices and funds to discuss the latest trends, and opportunities and to provide relevant insights into the longevity and rejuvenation subject. The 2.5 day conference is taking place in a private and exclusive setting of a 5* luxury hotel in Gstaad. Longevity will be one of the largest, if not the largest, investment opportunity in the decades to come. Learn more here!

Endlich ist es so weit, die langersehnte Folge rund um das Thema Longevity ist draußen. Diese Woche sprechen Florian Gschwandtner & Martin Kaswurm in einer Spezialfolge mit dem Experten Dr. Matthias Kirchmayr, Medizinischer Leiter von dieFITMACHER, über das Thema Gesundheit, Longevity (Verlängerte Lebensspanne), Fitness, Nahrungsergänzungsmittel und vieles mehr.    Florian Gschwandtner & Martin Kaswurm sprechen über:    00:02:45 Dr. Matthias Kirchmayr   00:05:45 Quick Wins  00:07:34 Nahrungsergänzungsmittel  00:16:15 Konsumverhalten & Processed Food  00:18:37 Blue Zone  00:20:28 Energie, Zelle, Stress & Genetik  00:26:55 Schlaf  00:29:16 Stress  00:32:50 Darm (Intervallfasten, Vegane Ernährung)  00:44:15 Training Cardio vs. Kraft & der VO2max Wert  00:56:00 Health Check & Kosten  01:10:00 Ausblick auf nächste Woche zu Fitness, die Fußball EM usw.    Disclaimer    Quick Wins:  Nährstoffversorgung Stress im Griff haben  Bewegung Richtige Ernährung  Take: Fix the Basics (Blutbild, Zellfunktionen, Stress, Darm, Herz-Lungenfunktion, VO2max-Wert)    Links zum Nachlesen:  dieFITMACHER  Dr. David A. Sinclair's Buch „Lifespan: Why We Age – and Why We Don't Have To” Buch „The Complete Blue Zones: Lessons From the Healthiest Places on Earth“ von Dan Buettner „Wie wird man 100 Jahre alt? – Die Geheimnisse der Blauen Zone“ auf Netflix  Der Huberman Lab Podcast Buch “Outlive: The Science and Art of Longevity” von Peter Attia MD Brian Johnson Blueprint  Die Steps App Die Foxy Fitness App Wimhof Atmen zum Nachschauen Buch "Breath - Atem: Neues Wissen über die vergessene Kunst des Atmens | Über das richtige Atmen und Atemtechniken" von James Nestor Feedback & Hörerfragen immer gerne an info@btm-podcast.com

The latest research and ideas around longevity and how to de-age from the inside – covering everything from supplements and at-home DNA tests through to a more holistic approach to skincare and aesthetics.

Modern life is silently destroying our health. But what if the real culprit isn't too much fat, but too little muscle? Dr. Gabrielle Lyon, a physician researching the overlooked importance of muscle for metabolism, immunity, and disease prevention, reveals how the loss of muscle mass as we age secretly undermines health. In her groundbreaking book, Forever Strong: A New, Science-Based Strategy for Aging Well, Dr. Lyon shares how you can slow, stop and even reverse muscle loss through science-based nutrition and exercise. Imagine if simply building muscle could lower disease risk and make you feel better. Dr. Lyon is on a mission to revolutionize aging. If you want to thrive in midlife and beyond, this conversation could change your life.You can find Dr. Lyon at: Website | Instagram | Episode TranscriptIf you LOVED this episode you'll also love the conversations we had with David A. Sinclair, Ph.D. about increasing lifespan. Check out our offerings & partners: My New Book SparkedMy New Podcast SPARKED. To submit your “moment & question” for consideration to be on the show go to sparketype.com/submit. Visit Our Sponsor Page For Great Resources & Discount Codes Hosted on Acast. See acast.com/privacy for more information.

What if the secret to living longer wasn't just kale and spin class, but transforming your whole environment and community? After decoding longevity hotspots he introduced as the Blue Zones, Dan Buettner discovered their vitality ensues from ecosystems promoting natural movement, plant-based eating, purpose, community, and stress reduction. These universal experiences shape our ability to build deeply healthy lives, yet we rarely learn from those who've mastered the art - the world's most vigorous centenarians.I'm thrilled to share this myth-busting conversation to glean simple, enjoyable lessons on adding life to our years from the wisdom of history's most remarkable super-agers. Join me and Dan, author of The Blue Zones Secrets for Living Longer, as we sidestep pitfalls by infusing our lives and communities with insights from the globe's greatest teachers on living well past 100.You can find Dan at: Website | Instagram | Episode TranscriptIf you LOVED this episode you'll also love the conversations we had with David A. Sinclair, Ph.D. offering a different and complimentary lab-based take on longevity. Check out our offerings & partners: My New Book SparkedMy New Podcast SPARKED. To submit your “moment & question” for consideration to be on the show go to sparketype.com/submit. Visit Our Sponsor Page For Great Resources & Discount Codes Hosted on Acast. See acast.com/privacy for more information.

In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age-related diseases. The study, conducted by a team of scientists at Harvard Medical School, has published the first chemical approach to reprogram cells to a younger state. Previously, this was only achievable using a powerful gene therapy. On July 12, 2023, researchers Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, and David A. Sinclair from Harvard Medical School, University of Maine and Massachusetts Institute of Technology (MIT) published a new research paper in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.” The team's findings build upon the discovery that the expression of specific genes, called Yamanaka factors, could convert adult cells into induced pluripotent stem cells (iPSCs). This Nobel Prize-winning discovery raised the question of whether it might be possible to reverse cellular aging without causing cells to become too young and turn cancerous. In this new study, the researchers screened for molecules that could, in combination, reverse cellular aging and rejuvenate human cells. They developed high-throughput cell-based assays to distinguish young cells from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic protein compartmentalization (NCC) assay. In an exciting discovery, the team has identified six chemical cocktails that restore NCC and genome-wide transcript profiles to youthful states and reverse transcriptomic age in less than a week. The Harvard researchers previously demonstrated that it is indeed possible to reverse cellular aging without uncontrolled cell growth by virally-introducing specific Yamanaka genes into cells. Studies on the optic nerve, brain tissue, kidney, and muscle have shown promising results, with improved vision and extended lifespan observed in mice and, recently, a report of improved vision in monkeys. The implications of this new discovery are far-reaching, opening avenues for regenerative medicine and, potentially, whole-body rejuvenation. By developing a chemical alternative to age reversal via gene therapy, this research could revolutionize the treatment of aging, injuries and age-related diseases and offers the potential for lower costs and shorter timelines in development. On the heels of positive results in reversing blindness in monkeys in April 2023, preparations for human clinical trials of the lab's age reversal gene therapy are in progress. “Until recently, the best we could do was slow aging. New discoveries suggest we can now reverse it,” said David A. Sinclair, A.O., Ph.D., Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and lead scientist on the project. “This process has previously required gene therapy, limiting its widespread use.” The team at Harvard envisions a future where age-related diseases can be effectively treated, injuries can be repaired more efficiently, and the dream of whole-body rejuvenation becomes a reality. “This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating numerous age-related diseases,” Sinclair said. Press Release: https://www.aging-us.com/news_room/NEW-STUDY-Discovery-of-Chemical-Means-to-Reverse-Aging-and-Restore-Cellular-Function DOI: https://doi.org/10.18632/aging.204896 Corresponding Author: David A. Sinclair - david_sinclair@hms.harvard.edu Visit https://www.Aging-US.com​​ and connect with us on social media. MEDIA@IMPACTJOURNALS.COM

Kurt and I have been married for almost 23 years and we're planning on another 50 to 75 together. We think, in terms of taking care of our bodies, minds and spirits and given the way technology is going, we could each live to be well over a hundred which gives us an amazingly long time to grow in love together and to contribute in so many other parts of our lives. Today's episode is about how we think about what I call, for shorthand “The 100-Year Marriage” and how you could think about it too. In this episode, we'll cover:Why you should think about the long-term plan for your relationshipThe areas of your life you should consider as you look at the next 50 or 75 yearsQuestions you can ask yourself and each other to help define your vision for long lives togetherResources that have helped expand my thinking about longevity and legacyAnd more.  Join the conversation by listening, then share your story or response on our voicemail at 206-659-9865 or inside our free Conscious Couples' Circle on Mighty Networks.“You get to have any marriage, you're up for creating.”-Michele Lisenbury ChristensenHot Moments in This Episode:How to plan for retirement... or not. (11:30)The books that changed my outlook on life (13:40)How you are living as if your relationship doesn't matter (27:46)I hope that your love can be a fountain that nourishes everything around it, an oasis that creates aliveness spreading out and out and out from you as a couple.RESOURCES OR LINKS MENTIONED IN THIS EPISODE: (if applicable)My Plan for Living to 156Cash Flow (game) by Robert KiyosakiThe 100 Year Life by Lynda Gratton & Andrew J. ScottFour Thousand Weeks by Oliver BurkemanOutlive by Peter AttiaLifespan by David A. Sinclair & Matthew D. LaPlanteBuilt to Move by Kelly Starret If the conversations on this podcast are resonating for you and you want to create the love, sex, and aliveness you desire with more ease, I invite you to enter a deeper relationship with me, through private coaching or my group mentorship program. Either way, you get powerful tools, conversation cheat sheets, meditations, and my loving and skillful attention every month. CLICK HERE to apply for a consultation.

Warum nehme ich seit Jahren kalte Duschen? Was macht Kältekammern so gesund? Wie kalt sollte ein Eisbad sein? Das und vieles mehr erkläre ich dir in dieser Kältetherapie Masterclass mit der Hilfe von Wim Hof, Dr. Andrew Huberman und Dr. David A Sinclair. - BLINKIST 7 TAGE KOSTENLOS TESTEN: Anzeige: Sponsor dieser Episode ist Blinkist. Blinkist bringt die Kernaussagen von Wissensformaten auf dein Smartphone – in nur 15 Minuten pro Titel. Teste 7 Tage kostenlos und erhalte 25% auf das Jahresabo Blinkist Premium unter: www.blinkist.de/axel - VIDEOQUELLEN: Erste Sequenz (Dr. Andrew Huberman): https://www.youtube.com/watch?v=7sjJAyK45Ws Zweite und dritte Sequenz (Dr. Andrew Huberman): https://www.youtube.com/watch?v=pq6WHJzOkno Vierte Sequenz (Wim Hof): https://www.youtube.com/watch?v=8GgAoZUYAvY Fünfte Sequenz (Dr. David A Sinclair): https://www.youtube.com/watch?v=4Yc5EXX9YWg - MEINE WEBSITE: http://axelschura.com/ - COMMUNITY: × Unser nächstes Fire Within Retreat: https://axelschura.com/awaken-your-life-energy × Werde teil unserer exklusiven Membership: https://axelschura.com/membership - COACHING: × Kostenloses Erstgespräch: https://calendly.com/cedricflentje/claritycall × Trage dich auf meine Prioritätsliste ein: https://axelschura.ck.page/b54302eb52 - KURSE: × Human Design Zertifizierung: https://calendly.com/cedricflentje/human-design-certification × Virtual Assistant Blueprint: https://axelschura.com/virtual-assistant-blueprint/ - SOCIALS: × Instagram: https://instagram.com/axelschura × Englischer YouTube Channel: https://www.youtube.com/@axelschura × Role Model Podcast (EN): https://anchor.fm/axel-schura × Vegan Aber Richtig Podcast (DE): https://open.spotify.com/show/74iA9ULpZnjfm46y8zegLQ - MEINE NAHRUNGSERGÄNZUNGSMITTEL × Kostenloses B12 mit dem Code "FREEB12": https://www.vivolife.co.uk/?rfsn=3978221.84477e&utm_source=Refersion&utm_medium=Affiliates&utm_campaign=3978221

Question for you: what if you could slow down, stop or even reverse your aging process? What if you could live, not just longer, but better? Extending and even potentially expanding your physical and mental health and well-being. Staving off decline or illness. Is any of that really possible, and what does cutting-edge science have to say?That is what we are talking about with today's guest. David Sinclair. David is a worldwide leader in aging research. He is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School.He's best known for his work on genes and small molecules that delay aging, including the sirtuin genes and resveratrol and its precursors, which we get into. He's published over 170 scientific studies, is the co-inventor on over 50 patents, has co-founded 14 biotechnology companies in the area of aging vaccines, diabetes, fertility Cancer Biodefense. His book Lifespan, Why We Age, and Why We Don't Have To explores what we get wrong about aging and how to approach it differently. And, his podcast, Lifespan, explores healthy aging and how to live not just longer, but better, too. So excited to share this Best Of conversation with you.You can find David at: Website | InstagramIf you LOVED this episode you'll also love the conversations we had with Aviva Romm, MD about how hormones control health, and what we can do about it.Check out our offerings & partners: My New Book SparkedMy New Podcast SPARKEDVisit Our Sponsor Page For a Complete List of Vanity URLs & Discount Codes.Peloton: Access high-energy workouts, instantly. Discover Peloton: streaming fitness classes to you live and on-demand. Try Peloton risk-free with a 30 Day Home Trial. New Members only. Not available in remote locations. See additional terms at www.onepeloton.com/home-trial. Hosted on Acast. See acast.com/privacy for more information.

#71 - Darf man Intervallfasten zum Abnehmen benutzen? Oder ist es nur etwas, das für die Gesundheit getan werden sollte? Ist es vielleicht sogar schädlich, es für die Steuerung des Gewichts zu nutzen? Antworten darauf und einige Impulse bekommst du in diesem Beitrag, viel Freude damit! Unter folgendem Link findest Du die Beitragsseite: www.iamfasting.de/p71

Buchbesprechung von David Sinclairs Das Ende des Alterns" mit Sportpsychologe Nils Gatzmaga. Diese Buch verspricht Folgendes: David A. Sinclair ist einer der größten Durchbrüche in der Biologie gelungen: Er hat das Altern bei Labortieren nicht nur verlangsamt, sondern umgekehrt. Wenn auch die Versuche mit Menschen an der Harvard-Universität gelingen, wird bald die erste Anti-Aging-Pille auf den Markt kommen. Unser Genom nimmt über die Jahrzehnte Schaden. Diese Schäden unserer DNA-Stränge lassen uns altern und machen uns anfälliger für Krankheiten. Das Epigenom – jene pulsierende Struktur, in die unser Genom eingewickelt ist – bestimmt, welche unserer Gene wirksam werden und welche nicht. Werden Gene abgeschaltet, schädigt dies den Organismus. David A. Sinclair erforscht, wie man die richtigen Gene wieder aktivieren und so den Organismus heilen kann.Derzeit stecken amerikanische IT-Unternehmen ebenso wie der chinesische Staat Milliarden in die Forschung, damit die epigenetische Revolution bald Wirklichkeit wird. Dies wird zu spannenden Möglichkeiten, aber auch zu tiefgreifenden moralischen und strategischen Dilemmata führen.   Themen und Links: Homepage David Sinclair Resveratrol NMN Rapamycin Tipp Podcastinterview mit Matt Kaeberlein siehe auch: Jessica Braun zu Gast im Atemcodeclub ------------------------- Der Atemcodeclub! Gehe direkt zur Anmeldeseite Im Clubbereich gibt es jetzt auch eine Wim Hof Atemsession, die mit eigens dafür komponierter Musik von Schallpause unterlegt ist. Das ist also eine Möglichkeit, das zu testen und ganz besondere Wirkungen mit Atmung zu erzeugen!!! Die Clubmitgliedschaft, die monatlich kündbar ist, ist bezogen auf die virtuelle Plattform; Treffen und Events finden über Zoom statt. ---------------------------- Ein Tool, das in Fachkreisen ein absoluter Geheimtipp für bessere Regeneration, mehr Energie und optimalem Schlaf ist, ist Schallpause! Mit Hilfe der App von Schallpause kannst Du spezielle frequenzmodulierte Musik hören, die auf der Grundlage der Polyvagal Theorie von Stephen Porges therapeutische Wirkungen erzeugt. Dieser Effekt wird durch eine Vielzahl von Klangverschiebungen, Soundmodulationen und andere technische Effekte produziert. Wenn Du auf die Homepage gehst, kannst Du mit dem Discountcode atemcodeclub 20% auf ALLE Angebote einsparen. ----------------------------- Mehr über mich und meine Arbeit findest Du hier. matthiaswittfoth.de

Do you sometimes feel like you are working so hard for your job and taking care of others, that you don't know what to do to take care of yourself? And even if you did…when would you do it?!Or maybe you are watching your partner working overtime and you feel like there is no time left for you and your family? You know they mean well, trying to provide for the family…but in the end, you see the depleted person that you love that is exhausted. And even when they are around, it's like they are there physically, but they aren't fully present. My guest, Dr. Tracy Gapin found himself in a similar situation and he is here to tell us about his transformation after his wife encouraged him to get help. That simple request changed the trajectory of his life and the lives of many others. After taking responsibility for his own health, he opened the Gapin Institute to offer personalized paths to help men maximize sexual health, testosterone levels, and prostate health. Dr. Gapin wants others to find their path to fulfillment, performance, and presence in life. He also wrote a book called Male 2.0: Cracking the code to limitless health and vitality where he breaks down the tangible concepts you can implement in your life. We cover longevity, erectile dysfunction, and functional wellness tips on how to not just live longer, but live better! I look forward to hearing your thoughts on this conversation! In this episode:01:45 – Dr. Gapin shares how he found human optimization and high performance03:30 – What is longevity? Healthspan versus lifespan04:40 – Dr. Gapin discusses performance medicine06:05 – How do all of these things relate to sexual health?09:10 – Dr. Gapin explains what optimal performance and biohacking is11:15 – Dr. Gapin shares the changes he implemented and how they made his life better16:20 – What is Dr. Gapin's Why?18:00 – What are some of the things that Dr. Gapin does to prioritize his relationship with his wife over taking care of others?20:40 – Dr. Gapin discuss some basic health problems and simple habits to support performance optimization22:50 – Dr. Gapin talks about his book, Male 2.0 - https://amzn.to/3xn8mr824:50 – What is high performance?26:10 – Dr. Gapin shares some of the things that inspired him in his journeyLifespan by David A. Sinclair - https://amzn.to/3MDX6weHow to Win Friends and Influence People by Dale Carnegie - https://amzn.to/3OoBq8P26:30 – Dr. Gapin talks about the programs that they offer and how simple coaching helps men achieve a high performanceDr. Gapin's Website: https://gapininstitute.com/Support the show

I'm excited to introduce this week's guest, Dr. Molly Maloof, who has been at the forefront of how biohacking, functional medicine, and personalized healthcare can be used to optimize your health.  Dr. Molly provides personalized medicine to world class entrepreneurs, investors, and technology executives in Silicon Valley. She has also worked as an advisor or consultant to over 50 companies in the digital health, consumer health, and biotech industries, and she's currently writing a book on biohacking for women. Dr. Molly gives so much incredible information on this episode that you can start implementing today. To make it a little bit easier, I created this free downloadable “Optimize Your Health Checklist” that lists out Dr. Molly's recommended steps for achieving optimal health. On Ep. 176, we cover: Dr. Molly's background: Her path away from “traditional” medicine to create her own lane Biohacking 101: How to start optimizing your health (with lots of actionable specifics!) Why women and men need to take different approaches to biohacking Testing you should be doing, supplements you need to take, and more specific recommendations from Dr. Molly.  Her new venture as the founder and CEO of Adamo Bioscience, a company pioneering the science of love The biggest driver of long term happiness and health, and more! **Please note that this is for informational purposes only, and is not intended to be taken as medical advice. Free Resource! Get my 3 favorite FREE self-compassion guided meditations for entrepreneurs from Dr. Kristin Neff here: https://www.brittanykrystle.com/optimize Dr. Molly's Book Recommendations Power vs. Force: The Hidden Determinants of Human Behavior by David R. Hawkins, M.D., PhD https://amzn.to/3ELNptc Real Magic: Ancient Wisdom, Modern Science, and a Guide to the Secret Power of the Universe by Dean Radin, PhD https://amzn.to/39eXrHJ The Mood Cure: The 4-Step Program to Take Charge of Your Emotions--Today by Julia Ross, M.A. https://amzn.to/3vDQCae The Anatomy of Anxiety by Ellen Vora, M.D. https://amzn.to/3Msxjri   My Book Recommendations Glucose Revolution: The Life-Changing Power of Balancing Your Blood Sugar by Jessie Inchauspé https://amzn.to/3keU05V State Change: End Anxiety, Beat Burnout, and Ignite a New Baseline of Energy and Flow by Robin Berzin, MD https://amzn.to/3LBmseF Lifespan: Why We Age—and Why We Don't Have To by David A. Sinclair, PhD, AO, and Matthew LaPlante https://amzn.to/3vhyrIs Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love by Tony Robbins, Peter H. Diamandis, MD, and Robert Hariri, MD, PhD https://amzn.to/3keGNKm   Recommended Products and Suppplements Oura ring https://ouraring.com/ Garmin vivosmart 4 https://amzn.to/3kdgPXJ  Upgraded Formulas - mineral and metal testing https://bit.ly/37HT1sB Levels Health - App-Based Continuous Glucose Monitor https://www.levelshealth.com/join?partner=DRMOLLY&campaignid=36303 Genova Diagnostics - allergy testing (food, molds, airborne) https://www.gdx.net/product/igg-food-antibodies-food-sensitivity-test-blood  Parsley Health (affordable functional medicine doctors) https://www.parsleyhealth.com/ Qualia Skin Science-Backed Radiance -  https://amzn.to/3ka43cF Zembrin - natural mood booster https://amzn.to/3EWIqpF Omega Supplement:Thorne Super EPA https://amzn.to/3Mw7oPf Vitamin D3 and K2 Liquid Supplement https://amzn.to/3KiKmK8 KAL B-12 Methylcobalamin Active Melt Raspberry Tablets https://amzn.to/3vkVyC3 Some reputable supplement brands:Quicksilver Scientific (https://amzn.to/392ksNS),Thorne (https://amzn.to/3k6XxDC),Metagenics (https://amzn.to/3MoD8Wz)  Want to Support the Podcast for free? Leaving a rating goes a long way and allows me to continue putting out quality content! You can leave one on Apple (https://podcasts.apple.com/us/podcast/beyond-influential/id1264581842) or Spotify (https://open.spotify.com/show/0Z55W0OeqRN9VHhVVDQaMD)! Take a screenshot while listening to the episode and share it in your Instagram Stories—and make sure to tag me @brittanykrystle!   To connect with Dr. Molly: Website: https://drmolly.co/ Facebook: https://www.facebook.com/MollyMaloofMD/   Twitter: https://twitter.com/mollymaloofmd   Instagram: https://www.instagram.com/drmolly.co/   To connect with me, Brittany Krystle: Website: https://www.brittanykrystle.com/ Instagram: https://www.instagram.com/brittanykrystle/ Twitter: https://www.twitter.com/brittanykrystle/   LinkedIn: https://www.linkedin.com/in/brittanykrystle/   Facebook: https://www.facebook.com/brittanykrystlexoxo/   Pinterest: https://www.pinterest.com/brittanykrystle/   YouTube: https://www.youtube.com/channel/UC1f0uI6wzWqp58n7fk-7-1g     Don't want to miss an episode (or valuable free resources!)? Get on my list here: https://www.brittanykrystle.com/subscribe   *Disclosure: These show notes may contain affiliate links. If you choose to purchase through them, I may earn a commission which helps me continue to create this content (at no extra cost to you). Thank you so much for your support.

The Bros are once again joined by long time bro Ramsey Callahan. He catches up the guys on some incredible breakthroughs regarding the aging process by discussing David Sinclair's Lifespan. Kenny then uses Bleachers by John Grisham as an excuse to tell stories about a surly, but hilarious football coach that all three shared while attending Middleton High School. James opted out of reviewing a book in lieu of telling more incredible stories about the legendary Coach Larry Wright. Links from today's show: Lifespan Bleachers The Toughest American Predator Undaunted Courage --- Send in a voice message: https://anchor.fm/kenny-james65/message

Humanity has long imagined a future where humans could live for hundreds of years, if not forever. But those ideas have been the stuff of science fiction, up until now. There's growing interest and investment in the realm of biohacking and de-aging, and leading scientists such as Harvard's David A. Sinclair are bringing the idea of extended lifespans out of fantasy into a reality we may see within our generation. But a world where more people are living a lot longer than ever thought possible will have sweeping economic and social consequences. In this episode of Big Tech, host Taylor Owen speaks with journalist Matthew D. LaPlante, co-author of Lifespan: Why We Age — And Why We Don't Have To with David A. Sinclair. LaPlante's focus is on the impacts longer lifespans will have, rather than on the technology involved in achieving de-aging. For example: When people live longer, where do we set the retirement age? Can the planet support more humans? And how will we deal with our past choices when we live long enough to see their impacts on our great-great-grandchildren?In this wide-ranging conversation, Taylor and Matthew discuss more implications longer life would have on our society. In the justice system, appointing a 50-year-old to the Supreme Court looks very different when that person could live to 110 rather than 80. What about geopolitical stability, if autocrats and dictators can extend their lives to maintain power for much longer periods? And what are the implications for medical privacy when technology companies are using monitoring devices, such as the ubiquitous smart watch, in conjunction with artificial intelligence to predict when someone may develop an illness or have a heart attack? 

El gran invitado de hoy es Matias Serebrinsky, Partner de Psymed Ventures, un fondo de inversión y grupo que invierte en tecnologías que elevan el bienestar y la salud mental. En general su enfoque es en psicodelicos, neurotecnologia, medicina de precisión y terapias digitales. Matías nos cuenta un poco de sus emprendimientos anteriores con su esposa y los parendizajes que le trajeron las aceleradoras en las que estuvo, como es que llegó a tener burnout y así inicio su propio proceso de sanación que lo llevaron a introducirse en el mundo de la medicina con psicodélicos; nos cuenta de las terapias que se realizan y la regulación de estos tratamientos. Aprendí muchísimo de esta entrevista y estoy seguro que tu también lo harás así que no te la pierdas! Donde quiera que estés no olvides dejarnos una reseña Libros mencionados:El cuerpo lleva la cuenta - Bessel van der KolkAlarga Tu Esperanza de Vida (Why we age, why we don't) - Dr. David A. Sinclair Sobre el invitado:Conecta con Matías en LinkedinBusiness Trip | PodcastTwitter | Matías PsyMed Ventures | Website Follow Us:NewsletterEscribe una ReseñaEncuesta de AudienciaTikTokInstagramTwitterLinkedinWeb

At least at one point in our lives, we will all experience body pains and headaches. However, did you know that these may be signs of a vitamin deficiency? Around 60-70% of Americans are calcium and magnesium deficient. We may be vitamin deficient and not even notice it! That's why it's vital to be tracking biometric markers.  Tracking biometric markers and our nutrient levels can be a challenge because of the need to go to clinics regularly for blood tests. Fortunately, there's a new technology that can help you check your biometric markers in the safety and comfort of your own home. In this episode, Miray Tayfun discusses how Vivoo can track biometric markers at home. Vivoo can monitor your hydration, liver and kidney functions, Vitamin C, magnesium, and more.  Don't wait until symptoms start. Stay on top of your health with constant awareness! If you want to learn more about tracking biometric markers, then this episode is for you! Here are three reasons why you should listen to the full episode: Learn how home diagnostic tools like Vivo can help you stay on top of your health.  Discover how tracking biometric markers can optimise your health  Know more about the other necessary actions you need to take to be healthier.   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [04:02] How Miray Started Vivoo Miray is knowledgeable in bioengineering and epigenetics. Her expertise is on the Internet of Things and biosensors.  Vivoo means being alive in Spanish.  It is a home diagnostics tool that helps in tracking biometric markers through urine. The application can measure hydration, liver and kidney functions, urinary tract infections, and ketones.    [06:43] Why Health Tracking is Important When you are aware of your health statistics, it's easier to take action.   If you're tracking biometric markers regularly, you'll learn about their patterns and changes.  Miray shares that Vivoo is also adding new metrics like calcium, vitamin C, magnesium, salt consumption, and free radicals. [10:43] Looking Out for Oxidative Stress Oxidative stress is involved in cell damage and diseases like cancer.  Free radicals can lead to oxidative stress. They can be found in food, objects, and even cosmetics.  Oxidative stress is a byproduct of lipid peroxidation and malondialdehyde (MDA).  [14:21] Who Can Use Vivoo? Many athletes use Vivoo to track their status before and after runs.  Vivoo can help people become more proactive in their health and understand their bodies' needs better.  On average, 70% of Americans are calcium deficient and 60% are magnesium deficient.  [19:33] How Does Vivoo Measure Oxidative Stress? When Vivoo uses colourimetric tests, speific molecules activate and change colours depending on the level of the biometric being measured.  People's health issues can be addressed by simply taking the right supplements and vitamins.  For example, magnesium can help in 600 enzymatic reactions and be a treatment for depression.     [24:17] How Medicine and the Medical Industry Should Change Medicine often cures only the symptoms, not the disease.  While medicines and treatments can address your symptoms, they won't treat vitamin deficiencies that might cause more significant problems for your body in the future.  Medical trends point to more home diagnostic tools to help people live longer and healthier.   Diabetes and obesity threatens the life expectancy of younger generations. [31:19] The Mindset to Become Stronger Looking for investors is just similar to looking for customers. You contact leads, pitch your sales, and hope to get funding.  It also requires mental toughness and optimism despite uncertainties.  When you believe in negative thinking, it then becomes a self-fulfilling prophecy.  [40:43] How Vivoo Can Help You Make Lifestyle Changes Take note that Vivoo only helps gauge biometric levels and you can make decisions based on them.  Many in the biohacking community want nutrient information. Miray's team added metrics for calcium, Vitamin C, magnesium, and salts.  Vivoo also explains the importance of tracking biometric markers.  We need supplementation because our food may not be in its prime condition. For example, Vitamin C in vegetables can oxidate to 90%.  Getting good food nowadays has become difficult due to processing, packaging, pesticides, and modifications.  [54:39] Vivoo and Tracking Biometric Markers Miray shares that Vivoo does not check one's overall health. When tracking liver functions, it only measures bilirubin which can check liver damage and cirrhosis.  The application also checks for proteins related to kidney function. Remember that even if you look healthy on the outside, it doesn't mean you're healthy.  7 Powerful Quotes   “...  I want to know this for my own health, and my family's health so I can track everybody's going.”   “And people like us — sometimes I see hesitancy and people like, why would I pee on a stick unhealthy? But like 70% of Americans are calcium deficient and absorption reduces 30% by age.”   “ …if I had done an ultrasound, even of his stomach — if we would have seen what was going on under the hood, we would have been able to stop the aneurysm happening in his aorta, and we would have been able to fix them. That's just so sad that I didn't have something that  could have scanned him and seen that, and fixed that before it became a deadly problem.”   “...we can have genetic disorders, environmentally-caused problems, etc. But our body has actually tools to overcome it most of the times, but they don't allow our bodies to basically find those tools and help itself. They just try to cure the symptom.”   “...this is exciting, because then we will have much more control. And we will be able to live longer and age better and have a healthier [life].”   "And I realised that my biggest weakness is when there's uncertainty, there's two ways. You can be either optimistic, believe in yourself and your dreams, and keep going, or you can go down and save."   “It's okay for you to cost a little bit, in my opinion. It's okay for you to want to live your life and to have a good retirement and some nice times before you depart this world. And it's worth fighting for.” Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Order your very own Vivoo strips now and use code Lisa25 to get a 25% off your purchase!  Lifespan by David A. Sinclair Learn more about NMN through our interviews with Dr Elena Seranova:  Episode 183: Sirtuins and NAD Supplements for Longevity  Episode 189: Autophagy and Increasing Your Longevity   Vivoo: Website I Instagram I Twitter   Connect with Miray: Linkedin I Twitter   About Miray  Miray Tayfun is the co-founder and CEO of Vivoo, the first affordable at-home wellness tracker that utilises urine to help people in tracking biometric markers and stay on top of their health. The application can detect metric levels such as hydration, pH, ketones, kidney and liver functions, among others.  Miray graduated from the Yildiz Technical University with a Bachelor of Applied Science, Bioengineering, and finished the Epigenetics and Nutrigenetics course at Stanford University.  Interested to learn more about Miray's work? Check out her website.  You can also connect with her on Linkedin and Twitter.       Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to begin tracking biometric markers and be as healthy as they can be. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa

The most successful people are also the most purposeful. They create a vision for the future and take steps to get a little better every day. They take the time to ask: Is my life working for me? If not, how would I like it to look different? David Osborn is the principal owner of the sixth largest real estate company in the US with 4,500-plus agents and $11B in annual sales. David also runs a real estate investing private equity firm and operates 35 other profitable real estate related businesses in the US and Canada. He is well-known for being one of the cofounders of GoBundance, a community of healthy, wealthy, generous men who choose to lead EPIC lives. On this episode of Financial Freedom with Real Estate Investing, David joins cohost Garrett Lynch and me to explain his tagline, ‘Who you become on your journey is far more important than what you achieve.' He offers insight on the value of connecting with the right people and growing into the best version of yourself. Listen in to understand why David's definition of wealth involves more than just money and find out how the most successful people get clear on where they're going and walk in purpose. Key Takeaways  How David became a real estate investor Got start as agent, opened KW franchises in TX, NM All-in on investing in 2011 but ran out of own capital Mission to meet wealthy people and raise money Establish fund to invest in single family rentals What investments David is bullish on right now Dwelling spaces and rentals (single and multifamily) Real estate in Sunbelt states with fewer regulations Why who you become is more important than what you achieve Controlling every decision makes you the bottleneck Leadership means delegating trust (world gets bigger) External world = reflection of who you are as human The areas of his life David is working on right now More present with wife and children Working with coach on conscious leadership Meditate on regular basis Health including workouts Learning (40 books/year and podcasts) How David thinks about finding work-life balance Worked 12-hour days to achieve financial freedom Work smarter now, better relationships at home David's well-rounded definition of wealth More than just money and financial freedom Being good human, finding ways to contribute Having adventures and being well-learned Why it's crucial to surround yourself with the right people Genius of humans = sharing and connectivity Find peers who push and inspire you to get better The GoBundance origin story Accountability partners with Pat Hiban, Tim Rhode Invite others to join in bucket-list adventures Growth comes from authenticity and transparency David's top lessons learned as an entrepreneur Know where you're going (purposeful vision for life) Invest in marriage and make time for kids Connect with David Osborn David's Website David on Instagram GoBundance Resources Be a Part of Michael's Deal Maker Mastermind Join the Nighthawk Equity Investor Club Entrepreneurs' Organization TIGER 21 Conscious Loving: The Journey to Co-Commitment by Gay & Kathlyn Hendricks The 15 Commitments of Conscious Leadership: A New Paradigm for Sustainable Success by Jim Dethmer, Diana Chapman & Kaley Klemp The Almanack of Naval Ravikant: A Guide to Wealth and Happiness by Eric Jorgenson Huberman Lab Podcast Wealth Can't Wait: Avoid the 7 Wealth Traps, Implement the 7 Business Pillars, and Complete a Life Audit Today! by David Osborn & Paul Morris Diego Corzo The Family Board Meeting: You Have 18 Summers to Create Lasting Connection with Your Children by Jim Sheils Lifespan: Why We Age—and Why We Don't Have To by David A. Sinclair Black Belt of the Mind by Fred Grosse Pat Hiban Tim Rhode Scott Harrison of Charity Water Gary Keller The Miracle Morning: The Not-So-Obvious Secret Guaranteed to Transform Your Life (Before 8AM) by Hal Elrod Richard Branson Tribe of Millionaires: What If One Choice Could Change Everything? by David Osborn & Pat Hiban Michael's Website  Michael on Facebook  Michael on Instagram  Michael on YouTube  Apartment Investor Network Facebook Group Podcast Show Notes

What if I told you that there's a way to keep yourself young? It takes a lot of hard work, and it's a continuing process. However, the payoff is definitely worth it. It also offers a lot of benefits aside from longevity. The secret? It's developing a lifelong passion for learning and growing. In this episode, Craig Harper joins us once again to explain the value of having a growth mindset. We explore how you can keep yourself young and healthy even as you chronologically age. He also emphasises the importance of fun and laughter in our lives. Craig also shares how powerful our minds are and how we can use them to manage our pain.    If you want to know how to develop a growth mindset for a fuller life, then this episode is for you!   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or are wanting to take your performance to the next level and learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third-party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Here are three reasons why you should listen to the full episode: Learn how to develop a growth mindset to keep yourself young and healthy, regardless of your chronological age. Understand why you need to manage your energy and plan fun and laughter into your life. Discover the ways you can change your mindset around pain.    Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Listen to other Pushing the Limits Episodes: #60: Ian Walker - Paraplegic Handbiker - Ultra Distance Athlete #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #188: Awareness and Achieve High Performance with Craig Harper  #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Craig: Website | Instagram | Linkedin Interested to learn more from Craig? You can check out his books and his podcast, The You Project. T: The Story of Testosterone by Carole Hooven  Mind Over Medicine by Lissa Rankin M.D. Lifespan - Why We Age and Why We Don't Have To  by David A. Sinclair PhD Neuroscience professor Andrew Huberman's Instagram  Dr Rhonda Patrick's website A new program, BoostCamp, is coming this September at Peak Wellness!   Episode Highlights [06:50] A Growth Mindset Keeps Us Young and Healthy It's helpful to take advantage of the availability of high-level research and medical journals online. If you're prepared to do the hard work, you can learn anything.  Learning and exposing ourselves to new things are crucial parts of staying young and healthy.  Age is a self-created story.  With a growth mindset, you can change how your body and mind works so that you feel younger than your real age.  [12:23] Develop a Growth Mindset It's vital to surround yourself with people with the same mindset — people who drag you up, not down.  You can also get a similar experience by exposing yourself to good ideas and stories. Be aware of what you're feeding your mind, on top of what you're feeding your body.  School is not a marker of your intelligence. Your academic failures do not matter.  With a growth mindset, you can keep growing and learning.  [17:40] Let Go and Be Happy People tend to have career and exercise plans, but not a fun plan.  We can't be serious all the time — we also need time to have fun and laugh.  Laughter can impact and improve the immune system. Laughing can change the biochemistry of your brain. Plan for the future, but also learn to live in the now. Having a growth mindset is important, but so is finding joy and enjoyment.  [23:31] Look After Your Energy Having fun and resting can impact your energy and emotional system.  These habits can help you work faster than when you're just working all the time.  Remember, volume and quality of work are different.  [30:24] Work-Life Balance Many people believe that they need to balance work and life. However, when you find your passion, it's just life.  Even doing 20 hours of work for a job you hate is worse than 40 hours of doing something you love. There's no one answer for everyone. Everything is a lot more flexible than before. Find what works for you.  [35:56] Change the Way You Think It's unavoidable that we think a certain way because of our upbringing.  Start to become aware of your lack of awareness and your programming.  Learn why you think of things the way you do. Is it because of other people?  Be influenced by other people, but test their ideas through trial and error. Let curiosity fuel your growth mindset.  Listen to the full podcast to learn how Craig learned how to run his gym without a business background!  [44:18] Sharing Academic Knowledge Academics face many restrictions due to the nature and context of their work.  He encourages the academic community to communicate information to everyone, not just to fellow researchers.  He plans to publish a book about his PhD research to share what he knows with the public. Science is constantly changing. We need to keep up with the latest knowledge.   [50:55] Change Your Relationship with Pain There is no simple fix to chronic pain.  The most you can do is change your relationship and perception of pain.  Our minds are powerful enough to create real pain even without any physical injury. Listen to Craig and Lisa's stories about how our minds affect our pain in the full episode!   7 Powerful Quotes from This Episode ‘My mind is the CEO of my life. So I need to make sure that as much as I can, that I'm managing my mind, and my mental energy optimally.' ‘If you're listening to this, and you didn't succeed in the school system, that means absolutely nothing when you're an adult.' ‘We're literally doing our biology good by laughing.' ‘Living is a present tense verb, you can't living in the future, and you can't live in the future.' ‘Often, more is not better. Sometimes more is worse.  So there's a difference between volume of work and output and quality of work.' ‘It's all about those people just taking one step at a time to move forward... That growth mindset that I think is just absolutely crucial.'   About Craig Craig Harper is one of Australia's leading educators, speakers, and writers in health and self-development. He has been an integral part of the Australian health and fitness industry since 1982. In 1990, he established a successful Harper's Personal Training, which evolved into one of the most successful businesses of its kind.  He currently hosts a successful Podcast called 'The You Project'. He is also completing a neuropsychology PhD, studying the spectrum of human thinking and behaviour. Craig speaks on various radio stations around Australia weekly. He currently fills an on-air role as a presenter on a lifestyle show called 'Get a Life', airing on Foxtel.  Want to know more about Craig and his work? Check out his website, or follow him on Instagram and Linkedin!   Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn how to develop a growth mindset. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa   Full Transcript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Well, hi everyone and welcome back to Pushing the Limits with Lisa Tamati. This week I have Craig Harper. He is really well known in Australia. He's a broadcaster, a fitness professional, a PhD scholar, an expert on metacognition, and self-awareness. And we get talking on all those good topics today and also neuro-psycho-immunology, very big word. Really interesting stuff; and we get talking about laughter, we get talking about pain management. We sort of go all over the show in this episode, which I sometimes do on this show. I hope you enjoy this very insightful and deep conversation with Craig Harper.  Before we head over to the show, I just want to let you know that Neil and I at Running Hot Coaching have launched a new program called Boost Camp. Now, this will be starting on the first of September and we're taking registrations now. This is a live eight-week program, where you'll basically boost your life. That's why it's called Boost Camp. not boot camp, Boost Camp. This is all about upgrading your body, learning how to help your body function at its base, learning how your mindset works, and increasing your performance, your health, your well-being and how to energise your mind and your body. In this Boost Camp, we're going to give you the answers you need in a simple, easy-to-follow process using holistic diagnostic tools and looking at the complete picture.  So you're going to go on a personalised health and fitness journey that will have a really life-changing effect on your family and your community. We're going to be talking about things like routine and resilience, mental resilience, which is a big thing that I love to talk about, and how important is in this time of change, in this time of COVID, where everything's upside down, and how we should be all building time and resources around building our resilience and energising our mind and body. We're going to give you a lot of health fundamentals. Because the fundamentals are something simple and easy to do, it means that you probably aren't doing some of the basics right, and we want to help you get there.  We're going to give you the answers you need in a simple, sort of easy, process. So we are now in a position to be able to control and manage all of these stressors and these things that are coming at us all the time, and we want to help you do that in the most optimal manner. So check out what boost camp is all about. Go to www.peakwellness.co.nz/boostcamp. I'll say that again, peakwellness.co.nz/boostcamp, boost with a B-O-O-S-T, boost camp. We hope to see you over there! Right, now over to the show with Craig Harper. Well, hi everyone and welcome to Pushing the Limits! Today, I have someone who is a special treat for you who has been on the show before. He's an absolute legend, and I love him to bits. Craig half and welcome to the show mate, how are you doing?  Craig Harper: Hi Lisa! I'm awesome but you're not.  Lisa: No I'm a bit of a miss, people. I've got shingles, a horrible, horrible virus that I advise nobody to get. Craig: What it— do we know what that's made? What causes it, or is it idiopathic as they say? Lisa: Yeah, no, it is from the chickenpox virus. Although, I've never, ever had that virus. So I'm like heck how, you know, it's related to the cold sore virus and all of that, which I definitely have had often. So it sits on the spinal cord, these little viruses, dormant and then one day when your immune systems are down, it decides to attack and replicate and go hard out. So yeah, that'll be the down for the count now for two and a half weeks. In a lot of pain, but— Craig: What is it like nerve pain or what kind of pain is it?  Lisa: Yes, it's nerve pain. So this one's actually, it hits different nerves in different people, depending on where it decides to pop out. My mum had the femoral nerve, which is one that goes right down from the backbone, quite high up on the backbone, down across the back and then down through the hip flexor and down the leg. I've got all these horrible looking sores, I look like a burn victim all the way down my leg and across my back. And it comes out through the muscles of your like, through the nerves and nerve endings and causes these blisters on top of the skin but it's the nerve pain that's really horrible because there's no comfortable position. There's no easy way to lie or sit and of course, when you're lying at night, it's worse. It's worse at nighttime than in the day. So I learned a lot about shingles. And as usual, we're using these obstacles to be a learning curve. Craig: Why on earth are you doing a bloody podcast? You should be relaxing. Lisa: You're important, you see. I had, you know, I had this appointment with you, and I honour my appointments, and I— Craig: Definitely not important. What's the typical treatment for shingles? Lisa: Well, actually, I wish I'd known this two weeks ago, I didn't know this, but I just had a Zoom call with Dave Asprey, you know, of Bulletproof fame, who is one of my heroes, and he's coming on the show, people, shortly. So that's really exciting. He told me to take something called BHT, butylated hydroxytoluene, which is a synthetic antioxidant. They actually use them in food additives, they said that kills that virus. So I'm like, ‘Right, get me some of that.' But unfortunately, I was already, it's— I only got it just yesterday, because I had to wait for the post. So I'm sort of hoping for a miracle in the next 24 hours.  Also, intravenous vitamin C, I've had three of those on lysine, which also helps. One of the funny things, before we get to the actual topic of the day, is I was taking something called L-Citrulline which helps with nitric oxide production and feeds into the arginine pathway. Apparently, while that's a good thing for most people, the arginine, if you have too much arginine in the body, it can lead to replication of this particular virus, which is really random and I only found that out after the fact. But you know, as a biohacker, who experiments sometimes you get it wrong.  Craig: Sometimes you turn left when you should have turned right.  Lisa: Yes. So that, you know, certainly took a lot of digging in PubMed to find that connection. But I think that's maybe what actually set it off. That combined with a pretty stressful life of like— Craig: It's interesting that you mentioned PubMed because like a lot of people now, you know how people warn people off going Dr Google, you know, whatever, right. But the funny thing is, you can forget Dr Google, I mean, Google's okay. But you can access medical journals, high level— I mean, all of the research journals that I access for my PhD are online. You can literally pretty much access any information you want. We're not talking about anecdotal evidence, and we're not talking about theories and ideas and random kind of junk. We're talking about the highest level research, you literally can find at home now. So if you know how to research and you know what you're looking for, and you can be bothered reading arduous academic papers, you can pretty much learn anything, to any level, if you're prepared to do the work and you know how— and you can be a little bit of a detective, a scientific detective.  Lisa: That is exactly, you know, what I keep saying, and I'm glad you said that because you are a PhD scholar and you are doing this. So you know what you're talking about, and this is exactly what I've done in the last five years, is do deep research and all this sort of stuff. People think that you have to go to university in order to have this education, and that used to be the case. It is no longer the case. We don't have to be actually in medical school to get access to medical texts anymore, which used to be the way. And so we now have the power in our hands to take, to some degree, control over what we're learning and where we're going with this.  It doesn't mean that it's easy. You will know, sifting through PubMed, and all these scholarly Google articles and things in clinical studies is pretty damn confusing sometimes and arduous. But once you get used to that form of learning, you start to be able to sift through relatively fast, and you can really educate yourself. I think having that growth mindset, I mean, you and I never came from an academic background. But thanks to you, I'm actually going to see Prof Schofield next week. Prof Schofield and looking at a PhD, because, I really need to add that to my load. But— Craig: You know, the thing is, I think in general, and I don't know where you're gonna go today, but I think in general, like what one of the things that keeps us young is learning and exposing ourselves, our mind and our emotions and for that matter, our body to new things, whether that's new experiences or new ideas, or new information, or new environments, or new people. This is what floats my boat and it keeps me hungry and it keeps me healthy physically, mentally, emotionally, intellectually, creatively, sociologically. It keeps me healthy. Not only does it keep me in a good place, I'm actually at 57, still getting better. You know, and people might wonder about that sometimes.  Of course, there's an inevitability to chronological aging. Clearly, most people at 80 are not going to be anything like they were at 40. Not that I'm 80. But there's— we know now that there's the unavoidable consistency of time as a construct, as an objective construct. But then there's the way that we behave around and relate to time. Biological aging is not chronological aging. In the middle of the inevitability of time ticking over is, which is an objective thing, there's the subject of human in the middle of it, who can do what he or she wants. So, in other words, a 57-year-old bloke doesn't need to look or feel or function or think like a 57-year-old bloke, right?  When we understand that, in many ways, especially as an experience, age is a self-created story for many people. I mean, you've met, I've met and our listeners have met 45-year-olds that seem 70 and 70-year-olds— and we're not talking about acting young, that's not what we're talking about. I'm not talking about that. I'm not talking about pretending you're not old or acting young. I'm actually talking about changing the way that your body and your mind and your brain and your emotional system works, literally. So that you are literally in terms of function, similar to somebody or a ‘typical' person who's 20 or 25 years younger than you. We didn't even know that this used to be possible, but not only is it possible, if you do certain things, it's very likely that that's the outcome you'll create. Lisa: Yeah, and if you think about our grandparents, and when I think about my Nana at 45 or 50, they were old. When I think about now I'm 52, you're 57, we're going forward, we're actually reaching the peak of our intellectual, well, hopefully not the peak, we're still going up. Physically, we got a few wrinkles and a few grey hairs coming. But even on that front, there is so much what's happening in the longevity space that my take on it is, if I can keep my shit together for the next 10 years, stuff's gonna come online that's gonna help me keep it on for another 20, 30, 40 years.  For me now it's trying to hold my body together as best I can so that when the technology does come, that we are able to meet— and we're accessing some of the stuff now, I mean, I'm taking some of the latest and greatest bloody supplements and biohacking stuff, and actively working towards that, and having this, I think it's a growth mindset. I had Dr Demartini on the show last week, who I love. I think he's an incredible man. His mindset, I mean, he's what nearly, I think he's nearly 70. It looks like he's 40. He's amazing. And his mind is so sharp and so fast it'll leave you and I in the dust. He's processing books every day, like, you know, more than a book a day and thinking his mind through and he's distilling it and he's remembering, and he's retaining it, and he's giving it to the world. This is sort of— you know, he's nothing exceptional. He had learning disabilities, for goodness sake, he had a speech impediment, he couldn't read until he was an adult. In other words, he made that happen. You and I, you know, we both did you know, where you went to university, at least when you're younger, I sort of mucked around on a bicycle for a few years. Travelling the world to see it. But this is the beauty of the time that we live in, and we have access to all this. So that growth mindset, I think keeps you younger, both physically and mentally. Craig: And this is why I reckon it's really important that we hang around with people who drag us up, not down. And that could be you know, this listening to your podcast, of course, like I feel like when I listen to a podcast with somebody like you that shares good ideas and good information and good energy and is a good person, like if I'm walking around, I've literally got my headphones here because I just walked back from the cafe, listening to Joe Rogan's latest podcast with this lady from Harvard talking about testosterone, you'd find it really interesting, wrote a book called T.  When I'm listening to good conversations with good people, I am, one, I'm fascinated and interested, but I'm stimulating myself and my mind in a good way. I'm dragging myself up by exposing myself to good ideas and good thinking, and good stories. Or it might even be just something that's funny, it might— I'm just exposing myself to a couple of dickheads talking about funny shit, right? And I'd spend an hour laughing, which is also therapeutic.  You know, and I think there's that, I think we forget that we're always feeding our mind and our brain something. It's just having more awareness of what am I actually plugging into that amazing thing? Not only just what am I putting in my body, which, of course, is paramount. But what am I putting in, you know, that thing that sits between my ears that literally drives my life? That's my HQ, that's my, my mind is the CEO of my life. So I need to make sure that as much as I can, that I'm managing my mind and my mental energy                                                                                  optimally. Lisa: Yeah. And I think, you know, a lot of people if they didn't do well in the school system, think that, 'Oh, well, I'm not academic therefore I can't learn or continue to learn.' I really encourage people, if you're listening to this, and you didn't succeed in the school system, that means absolutely nothing when you're an adult. The school system has got many flaws, and it didn't cater to everybody. So I just want people to understand that.  You know, just like with Dr Demartini, he taught himself 30 words a day, that's where he started: vocabulary. He taught himself to read and then taught— Albert Einstein was another one, you know, he struggled in school for crying out loud. So school isn't necessarily the marker of whether you're an intelligent human being or not. It's one system and one way of learning that is okay for the average and the masses. But definitely, it leaves a lot of people thinking that they're dumb when they're not dumb.  It's all about those people just taking one step at a time to move forward and becoming, you know, that growth mindset that I think is just absolutely crucial. You talked there about laughter and I wanted to go into that a little bit today too, because I heard you talking on Tiffany, our friend Tiffany's podcast, and you were talking about how important laughter is for the body, for our minds, for our— and if we laugh a lot, we're less likely to fall victim to the whole adult way of being, which is sometimes pretty cynical and miserable. When you think, what is it? Kids laugh something like 70 times a day and adults laugh I think, six times a day or some statistic. Do you want to elaborate on that a little bit? Craig: Well, I used to sit down with you know, I don't do much one-on-one coaching anymore, just because I do other stuff. I would sit with people and go, ‘Alright, tell me about your exercise plan and blah, blah, blah. Tell me about your career plan, blah, blah, blah. Tell me about your financial plan, blah, blah, blah.' Tell me about, you know, whatever. And they have systems and programs and plans for everything.  I would say to them, 'Do you like fun?' And they're like, they look at me like I was a weirdo. 'What do you mean?' I go, 'Well, what do you mean, what do I mean? Like, do you like having fun?' And they're like, very seriously, like, 'Well, of course, everyone likes having fun.' I go, 'Great. What's your fun plan?' And they go, 'What?' I go, 'What's your fun— like, is laughing and having fun important to you?' 'Yeah, yeah.' 'Okay, what's your fun plan?'  They literally, like this idea of just integrating things into my life, which are for no reason other than to laugh and to have fun. Not to be productive and efficient and to tick more boxes and create more income and elevate output and tick fucking boxes and hit KPIs and you know, just to be silly, just to laugh like a dickhead, just to hang out with your mates or your girlfriends, or whatever it is. Just to talk shit, just to, not everything needs to be fucking deep and meaningful and world-changing. Not everything. In fact, it can't, you know?  Our brain and our body and our emotional system and our nervous system and— it can't work like that we can't be elevated all the time. And so, literally when we are laughing, we're changing the biochemistry of our brain. You know, literally when we are having fun, we're impacting our immune system in a real way through that thing I've probably spoken to you about, psychoneuroimmunology, right? We're literally doing our biology good by laughing and there's got to be, for me, there's got to be, because, like you probably, I have a lot of deep and meaningful conversations with people about hard shit. Like, I'm pretty much a specialist at hard conversations. It's what I do. But, you know, and, and I work a lot, and I study a lot. Then there needs to be a valve. You can't be all of that all of the time because you're human, you're not a cyborg, you're not a robot. And this hustle, hustle, hustle, grind, work harder, sleep less, you can, you know, you can sleep when you're dead, it's all bullshit. Because, also, yeah, I want to learn and grow and evolve, and I want to develop new skills. But you know what, I want to also, in the moment, laugh at silly shit. I want to be happy and I want to hang out with people I love and I want to be mentally and emotionally and spiritually nourished.  Like, it's not just about acquiring knowledge and accumulating shit that you're probably not going to use. It's also about the human experience now. This almost sounds contradictory. But because of course, we want a future plan and we want goals and all of those, but we're never going to live in the present because when we get there, it's not the present. It's just another installment of now. So when next Wednesday comes, it's not the future, it's now again, because life is never-ending now, right?  It's like you only like, live— living is a present tense verb. You can't living in the future, and you can't live in the future. You cannot. Yes, I know, this gets a little bit, what's the word existential, but the truth is that, yeah, we need to— well, we don't, we can do whatever we want. But I believe we need to be stimulated so we're learning and growing, and we're doing good stuff for our brain and good stuff for our body. But also that we are giving ourselves a metaphoric hug, and going, 'It's all right to lie on your bed and watch Netflix, as long as it's not 20 hours a day, five days a week,' you know. It's okay to just laugh at silly stuff. It's okay, that there's no purpose to doing this thing other than just joy and enjoyment, you know.  I think that people like you and me who are, maybe we would put ourselves in the kind of driven category, right? You and I are no good at this. Like, at times, having fun and just going, ‘I'm going to do fuck all today.' Because the moment that we do sometimes we start to feel guilty and we start to be like, 'Fuck, I'm not being productive. I've got to be productive.' That, in itself, is a problem for high performance. Like, fuck your high performance, and fuck your productivity today. Be unproductive, be inefficient, and just fucking enjoy it, you know, not— because in a minute, we're going to be dead. We're going to go, 'But fuck, I was productive. But I had no fun, I never laughed, because I was too busy being important.' Fuck all that. Lisa: I think both of us have probably come a long way around finding that out. I mean, I used to love reading fiction novels, and then I went, ‘Oh, I can't be reading fiction novels. I've got so many science books that I have to read.' Here I am, dealing with insomnia at two o'clock in the morning reading texts on nitric oxide, you know. It is this argument that goes on, still in my head if there was an hour where you weren't learning something, you know, I can't. Because I know that if I go for a big drive or something, and I have to travel somewhere, or going for a long run or something, I've probably digested a book on that road trip or three, or 10 podcasts or something and I've actually oh, I get to the end and I'm like, ‘Well, I achieved something.' I've got my little dopamine hits all the way through.  Now I've sort of come to also understand that you need this time out and you need to just have fun. I'm married to this absolute lunatic of a guy called Haisely O'Leary, who I just love, because all day every day, he is just being an idiot. In the best sense of the word. I come out and I'm grumpy and you know, had a hard day and I'm tired, I'm stressed, and I come out and he's doing a little dance, doing some stupid meme or saying some ridiculous thing to me. I'm just like, you know, I crack up at it. That's the best person to have to be around because they keep being—and I'm like, ‘Come on, stop being stupid, you should be doing this and you shouldn't be doing that.' Then I hear myself, and I'm like, ‘No, he's got it right.' Craig: Well, I think he does, in some ways, you know. It's not about all, it's not about one or the other, it's about— and it's recognising that if I look after my energy, and my emotional system, and all of that, I'll get more done in 8 hours than 12 hours when I'm not looking after myself. So more is not better, necessarily. In fact, often, more is not better; sometimes, more is worse. So there's a difference between volume of work and output and quality of work. Also, you know, quality of experience.  I wrote a little thing yesterday, just talking on social media about the fact that I, like all of the things that I do, even study, although it's demanding, but I enjoy it. My job, you know, like, right now you and I do podcasts. I do seven podcasts a week, apart from the ones like this, where I'm being interviewed by someone else, or spoken to by somebody else. My life is somewhat chaotic, but I don't really, in terms of having a ‘job'. Well, one, I don't have a job. I haven't had a job since I was 26. Two, I don't really feel a sense of work, like most people do.  Like the other night, I did a gig. I don't know if you, if I posted a little thing about this on Insta, and I was doing a talk for Hewlett Packard in Spain. Now, how cool is the world? Right? So I'm talking here, right here in my house, you can see, obviously, your listeners can't. But this is not video, is it? Just us? I wish I knew that earlier. Sorry, everyone, I would have brushed my hair. But anyway, you should see my hair by the way. I look like bloody Doc from Back to the Future. Anyway, but I'm sitting in here, I'm sitting in the studio, and I'm about to talk to a few hundred people in Spain, right, which is where, that's where they're all— that's where I was dealing with the people who are organising me to speak.  Just before I'm about to go live at 5:30, the lady who had organised me was texting me. So it's on Zoom. There's already a guy on the screen speaking and then lots of little squares of other humans. I said to her, ‘How many?' and said, ‘You know, like a few 100.' I said, ‘Cool.' I go, ‘Everyone's in Spain,' and she goes, ‘No, no, we're in Spain, but the audience is around the world.' And I go, ‘Really? How many countries?' She goes, ‘38.' I'm sitting here and I'm thinking, I'm wearing a black t-shirt. I'm wearing my camo shorts. I've got bare feet. I'm talking to hundreds of humans from this big organisation in 38 countries, and I'm talking about the stuff that I am passionate about, right? I don't have to do any prep, because it's my default setting. I'm just talking. I had to talk for an hour and a half about high performance. Well, giddy up, that's like an hour and a half of breathing. You know?  I just had such fun, and I had this moment, Lisa, halfway through, I don't know, but about halfway through, where I'm like, I remember growing up in a paradigm where pretty much when I was a kid everyone went and got a job and you went, you became a cop or you sold clothes, or you're a bricky or sparky or you're some kind of tradie. A few of my super smart friends went to university. That was way over my head, I'm like, ‘Fuck university.' But there was literally about 50 jobs in the world. You know, it's like there was only 50 jobs, and everyone or nearly everyone fitted into one of those 50. There was a few other ones but for the most part, nearly everyone fitted into about 50 jobs. I'm sitting there going— I won't say what but I'm earning pretty good money. I'm sitting in bare feet in my house talking to humans around the world about this stuff that I want to tell everyone about anyway.  I do it for free on my podcast and your podcast and I do it anyway. I have this great time, it's a really good experience. Then I finish at 7 pm. Then I walk 15 feet into the kitchen and put the kettle on and check my messages.  Lisa: No commuting, no travelling, no flying. Craig: I'm like, ‘How is this a job?' I'm like, ‘How is this real?' ‘This is a scam. I'm scamming everybody.' Like, how great is 2021? I know there's a lot of shit going on and I'm not trying to be insensitive, and it's smashed my business too. All of my live events for 2020 got kicked in the dick in two weeks, right? I got financially annihilated, but you just go, ‘Oh well, improvise, adapt, overcome and figure shit out.' But, I think when you can have it and a lot of people and it's a very well-worn kind of idea. But when you're, what you love, and what you're curious about, and how you make a few bucks, when that can all collide, then life is a different thing. Then there's not work and life, there's just life.  You know, and so when we talk about this idea of work-life balance, you know, it's like the old days that talk about that a lot. And it's like, almost like there was some seesaw, some metaphoric seesaw with work on one side and life on the other. And when you get balance like that— because what happens, think about this, if we're just basing it on numbers, like all 40 hours of work versus however many hours of non-work or however many hours of recreation and recovery. But if you're doing even 20 hours of a job that you hate, that's going to fuck you up. That's gonna, that's gonna mess with you physically, mentally, and emotionally. That's going to be toxic; that's going to be damaging; that's going to be soul-destroying, versus something else like me studying 40 hours a week, working 40, 50 hours a week doing 90 in total, depending on the week and loving it, and loving it. And going, ‘I feel better than I've ever felt in my life.'  I still train every day, and I still, I live 600-800 metres from the beach, I still walk to the beach every day, you know. And I still hang out with my friends. You know, it's like, it doesn't have to be this cookie-cutter approach. The beauty I think of life, with your food, with your lifestyle, with your career, with your relationships with the way that you learn, like the way that you do business, everything now is so much more flexible, and optional than any time ever before that we can literally create our own blueprint for living. Lisa: Yeah. And then it's not always easy. And sometimes it takes time to get momentum and stuff. Being, both you and I have both said before we're unemployable. Like, I'm definitely not someone you want to employ, because I'm just always going to run my own ship. I've always been like that, and that's the entrepreneurial personality. So not everyone is set up for that personality-wise. So you know, we're a certain type of people that likes to run in a certain type of way. And we need lots of other people when doing the other paths.  There is this ability now to start to change the way you think about things. And this is really important for people who are unhappy in where they're at right now. To think, ‘Hang on a minute. I've been I don't know, policeman, teacher, whatever you've been, I don't want to be there anymore. Is there another me out there? Is there a different future that I can hit?' The answer is yes, if you're prepared to put in the work, and the time, and the effort, the looking at understanding and learning, the change, being adaptable, the risk-taking, all of those aspects of it. Yes, but there is ways now that you can do that where they weren't 30 years ago, when I came out of school I couldn't be, I was going to be an accountant. Can you imagine anything worse than that?  Craig: Hi, hi. Shout out to all our account listeners, we love you and we need you. Lisa: I wasn't that— Academically that's I was good at it. But geez, I hated it. And I did it because of parental pushing direction. Thank goodness, I sort of wake up to that. And you know, after three years. I had Mark Commander Mark Devine on the show. He's a Navy SEAL, man. You have to have him on the show. I'll hook you up. He's just a buck. He became an accountant before he became a Navy SEAL and now he's got the best of both worlds really, you know, but like you couldn't get more non-accountant than Mark Devine. We all go into the things when we leave school that we think we're meant to be doing. And they're not necessarily— and I think you know, the most interesting 50 year-olds still don't know what the hell they want to be when they grow up. Just interrupting the program briefly to let you know that we have a new Patron program for the podcast. Now, if you enjoy Pushing the Limits, if you get great value out of it, we would love you to come and join our Patron membership program. We've been doing this now for five and a half years and we need your help to keep it on air. It's been a public service free for everybody, and we want to keep it that way. But to do that we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on www.patron.lisatamati.com. That's P-A-T-R-O-N dot lisatamati.com. We have two Patron levels to choose from. You can do it for as little as $7 a month, New Zealand, or $15 a month if you really want to support us. So we are grateful if you do. There are so many membership benefits you're going to get if you join us. Everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries and much, much more. So check out all the details: patron.lisatamati.com. And thanks very much for joining us. You know, I'm still in that camp. Craig: You raise a really interesting point too, and that is programming and conditioning. And, you know, because we all grow up being programmed, one way or consciously or not, we grow— if you grow up around people, you're being programmed. So that's not a bad thing. That's an unavoidable human thing. So, situation, circumstance, environment, school, family, friends, media, social media, all of that stuff shapes the way that we see the world and shapes the way that we see ourselves.  When you grow up in a paradigm that says, ‘Okay, Lisa, when you finish school, you have to go to university, or you have to get a job, or you have to join the family business, or you have to work on our farm,' or whatever it is, you grow up in that. You're taught and told and trained. And so you don't question that, you know. And for me, I grew up in the 70s, I finished in the 80s. I finished school in 1981. And I grew up in the country, and most people go to trade or most people worked in logging or on a farm or— and I would say about five in 100 of the kids that I did— by the way, doing year 12 was a pretty big deal in that time. ‘Geez, are you a brainiac?' Definitely wasn't a brainiac. But year 12 is a big thing now. Now, even if you have an undergrad degree that it's almost nothing really enough. It's like, you kind of got to go get honours, or masters or maybe even a PhD down the track. And that landscape has really changed. So it's just changing again to— you know, and I think to become aware— like this is for me, I love it; this is my shit; this is what I love— is starting to become aware of our lack of awareness. And starting to become aware of my own programming and go, ‘Oh, I actually think this. Why not? Because this is how I naturally think about, because this is how I've been trained to think about work. I've been trained to or programmed to think this way about money, or relationships, or marriage, or eating meat, or being a Catholic or being an atheist or voting liberal law,' or whatever it is, right.  Not that any of those things are good or bad, but it's not about how I eat or how I vote or how I worship. It's about how I think. And is this my thinking? Or is this just a reflection of their thinking, right? So when we open the door on metacognition now we start to become aware of our own stories, and where they come from. And this is where I think we really start to take control of our own life, and our own present, and our own future that doesn't exist, by the way, but it will, but it won't be the present.  Then, we start to write our own story with our own voice, not our parents' voice, not our friends', not our peers' voice, you know. And we're always going to be influenced by other people. Of course. Just like people are influenced by you and your podcast, and your stories, and your thinking, and your lessons for them. They're influenced. But I always say to people, ‘Don't believe me because you like me. Listen to me, if you like me and consider what I say. If what I say sounds reasonable for you, maybe a good idea to test drive, take that idea for a test drive, and see if that works for you, because it might not.' Right?  I think, I really encourage people to learn for themselves and to listen to their own internal wisdom that's always talking. So listen to smart people. I don't know if Lisa and I are in that category, Lisa is, listen to her. But at the same time, do your own, learning through exploration and trial and error, and personal kind of curiosity and drive.  For me, I opened my first gym at 26; first personal training centre in Australia, there weren't any. I'd never done a business course, I've never done an admin course, I knew nothing about marketing. I knew nothing about employees. I knew nothing. But I learned more in one year than I would say, most people would learn in five years at university studying business, because I was in the middle of it, and I was going to sink or swim. So in one year, I started a business and I acquired overwhelming knowledge and skill because I had to, because of the situation. But that was all learning through doing.  The way that you've learned, you know you said earlier that, like, a lot of people think that they're not academic; therefore, they're not smart. Some of the smartest people I've ever met, and I don't— and this not being patronising, but like, mind-blowingly brilliant, how they think, live outside of academia. One of the reasons some people are so brilliant outside of academia is because they're not forced into an echo chamber of thought. They're living outside the academic paradigm, where we're not trying to restrict how you think or write or speak. There are no rules out here. So there's no intellectual inhibition.  Lisa: Yeah, I love that. Craig: When you do a PhD, like me, and I can separate the two, thankfully. But there's a way of communicating and writing in PhD land, which is incredibly restrictive because of the scientific process, which is fine, I get that. But it's having an awareness of— this is what I'm often talking to my supervisors about is, yes, I'm studying this thing, which is deep, deep neuropsychology, and everything, the way that you do your research, get your data or interpret your data. The whole process of creating new science, which is what you're doing as a PhD, creating, bringing something new into the world. That's one thing. But you write your journal articles, which is my PhD process, you get them, hopefully, you get them published in academic resources and magazines. But then, I don't want that to be it. I'm going to write a book when I finish about all of my research totally in layman's terms so that people can use the knowledge, so that people can— because that's the value.  For me handing in some papers and going, ‘Oh, Craig Harper is an academically published author.' That's cool, but it's not— and I'm so respectful of people who have had hundreds of things published, but that doesn't blow my socks off. I'm not really— like that's a real, you really hang your hat on that in academia. Oh, how many things he or she had published, publications, which is cool. They're all smarter than me. But I'm not. I'm like, yeah, that that's cool. But I want to connect with the masses, not the few. Also, by the way, people who read academic papers, they raise it— they're reading it generally, just like I am right now, for a specific reason which relates to their own research. There ain't too many people like you. You're one of the rare ones who just thumb through fucking academic journals to make your life better. Lisa: Yeah. And it's just some real goals. So you've got the wisdom of having lived outside of academia and being a pracademic, as Paul Taylor says, and then actually seeing the pre— and this is a discussion that I had when I was talking to someone about doing a PhD and they say, ‘But then you're going to become a part of the establishment, and you're going to be forced into this box.' And I said, ‘No, not necessarily because it's— I can see where you're coming from. But you can take that, because you have that maturity and that life experience and you can fit yourself into the box that you have to fit into in order to get those things done. That research done, but you don't have to stay there.'  That's what you know, one of my things has been, I don't want to spend however many years doing a PhD, and then that's not out on the world. To me that that needs to be taken out of the academic journals, wherever you go to publish, and then put out into a book or something that where it's actually shared, like you say, with the masses, because otherwise, it just collects dust like your MA does, or your whatever, you know, that sits on your bookshelf, and how you got hey, your exam your piece of paper, but you didn't actually do anything with it.  Of course, lots of people do their thing, they're going like they're in research, and they're furthering research and so on. But I— my approach, I think yours is too, is to be able to communicate that information that you've learned, and then share it with everyone, so that they can actually benefit from it, and not just the people that are in academia. The other thing I see after interviewing hundreds of doctors and scientists and people is that they are, actually, the more specialised they are, the more inhibited they are by what they can and can't say.  While they need to be doing that because they need to protect what they are doing in their studies and what they're allowed to and what they're not allowed to do and say, it also is very inhibiting, and they don't get the chance to actually express what they would actually like to say. That's a bit of a shame, really, because you don't get to hear the real truth in the qualifying everything flat stick. Craig: I reckon you're exactly right. But they don't need to be that. And the reason that a lot of academics are like that is because they get their identity and sense of self-worth from being an academic. They're way more worried about three of their peers hearing something that might not be 100% accurate, and then being reprimanded or, rather than just going— look, I always say to my academic, super academic friends, when I talk with them, not everything that comes out of your mouth needs to be research-based. You can have an idea and an opinion. In fact, I want to hear your ideas and opinions. Lisa: You're very educated. Craig: You know, that's the— and as for the idea of you becoming an academic, No, you go, you do your thing you study, you learn the protocol, the operating system, and you do that you go through that process, but you're still you. Right, and there's— you and I both know, there are lots of academics who have overcome that self-created barrier like Andrew Huberman.  Lisa: Yeah, who we love. Craig: Who we love, who, for people listening, he's @hubermanlab on Insta, and there's quite a few academics now, like the one that I spoke on before, on Joe Rogan. She's a Harvard professor, she's a genius, and she's just having a— it's a three-hour conversation with Rogan, about really interesting stuff.  There's been a bit of a shift, and there is a bit of a shift because people are now, the smart academics, I think, are now starting to understand that used the right way, that podcasts and social media more broadly, are unbelievably awesome tools to share your thoughts and ideas and messages. By the way, we know you're a human. If you get something wrong, every now and then, or whatever, it doesn't matter. Lisa: Well, we'll all get, I mean, you watch on social media, Dr Rhonda Patrick, another one that I follow? Do you follow her? Fantastic lady, you know, and you watch some of their feeds on social media, and they get slammed every day by people who pretending to be bloody more academic than her. That just makes me laugh, really. I'm just like, wow, they have to put up with all of that. The bigger your name and the more credibility you have as a scientist, the more you have to lose in a way.  You know, even David Sinclair another you know, brilliant scientists who loves his work. And I love the fact that he shared us with, you know, all his, all his research in real-time, basically, you know, bringing it out in the book Lifespan, which you have to read, in getting that out there in the masses, rather than squirrelling it away for another 20 years before it becomes part of our culture, and part of our clinical usage. We ain't got time for that. We have to, we're getting old now. I want to know what I need to do to stop that now. Thanks to him, you know, I've got some directions to show them. Whether he's 100% there, and he's got all the answers? No. But he's sharing where we're at from the progress. Science by its very nature is never finished. We never have the final answer. Because if someone thinks they do, then they're wrong, because they're not, we are constantly iterating and changing, and that's the whole basis of science. Craig: Well just think about the food pyramid. That was science for a few decades. Lisa: Lots of people still believe that shit. That's the scary thing because now that's filtering still down into the popular culture, that that's what you should be doing, eating your workbooks and God knows what. This is the scary thing, that it takes so long to drip down to people who aren't on that cutting edge and staying up with the latest stuff, because they're basically regurgitating what there was 20 years ago and not what is now.  Now Craig, I know you've got to jump off in a second. But I wanted to just ask one more question, if I may, we're completely different. But I want to go there today because I'm going through this bloody shingles thing. Your mate Johny that you train, and who you've spoken about on the last podcast, who had a horrific accident and amazingly survived, and you've helped him, and he's helped you and you've helped him learn life lessons and recover, but he's in constant chronic pain.  I'm in constant chronic pain now, that's two and a half weeks. For frick's sake, man, I've got a new appreciation of the damage that that does to society. I just said to my husband today, I've been on certain drugs, you know, antivirals, and in pain medication. I can feel my neurotransmitters are out of whack. I can feel that I'm becoming depressed. I have a lot of tools in my toolbox to deal with this stuff, and I am freely sharing this because what I want you to understand is when you, when you're dealing with somebody who is going through chronic pain, who has been on medications and antibiotics, and God knows whatever else, understanding the stuff that they're going through, because I now have a bit of a new appreciation for what this much of an appreciation for someone like Johnny's been through. What's your take on how pain and all this affects the neurotransmitters in the drugs? Craig: Do you know what? Lisa: You got two minutes, mate. Craig: I'm actually gonna give you I'm gonna hook you up with a friend of mine. His name is Dr Cal Friedman. He is super smart, and he specialises in pain management, but he has a very different approach, right? He's a medical doctor, but look, in answer to, I talked to Johnny about the pain a bit, and we have, we use a scale, obviously 10 is 10. 0 is 0. There's never a 0. Every now and then it's a 1 or 2, but he's never pain-free. Because he has massive nerve damage. And sometimes, sometimes he just sits down in the gym, and he'll just, I'll get him to do a set of something, and he'll sit down and I just see this, his whole face just grimaces. He goes, ‘Just give me a sec.' His fist is balled up. He goes, sweat, sweat. I go, ‘What's going on, mate?' He goes, ‘It feels like my leg, my whole leg is on fire.'  Lisa: Yeah. I can so relate to that right now.  Craig: Literally aren't, like, burning, like excruciating. I don't think there's any, I mean, obviously, if there was we'd all be doing it. There is no quick fix. There is no simple answer. But what he has done quite successfully is changed his relationship with pain. There is definitely, 100% definitely, a cognitive element to, of course, the brain is, because the brain is part of the central nervous system. Of course, the brain is involved. But there's another element to it beyond that, right.  I'm going to tell you a quick story that might fuck up a little bit of Dr Cal, if you get him on. He has done a couple of presentations for me at my camps. He's been on my show a little bit. But he told this story about this guy at a construction site that was working and he had a workplace accident. And he, a builder shot a three-inch nails through his boots, through his foot. Right? So the nail went through his foot, through the top of the leather, and out the sole, and he was in agony, right? He fell down, whatever and he's just rolling around in agony and his mates, they didn't want to take anything off because it was through the boot, through his foot.  They waited for the ambos to get there, and they gave him the green whistle. So you know that whatever that is, the morphine didn't do anything, he was still in agony. He was in agony. Anyway, they get him into the back of the ambulance and they cut the boot off. And the nail has gone between his big toe and second toe and didn't even touch his foot.  Lisa: Oh, wow. In other words, psychologically—  Craig: There was no injury. But the guy was literally in excruciating pain, he was wailing. And they gave him treatment, it didn't help. He was still in pain. So what that tells us— Lisa: There is an element of—  Craig: What that tells us is our body can, our mind can create real, not perceived, but real pain in your body. And again, and this is where I think we're going in the future where we start to understand, if you can create extreme pain in your body where there is no biological reason, there is no actual injury, there's no physical injury, but you believe there's an injury, now you're in agony.  I think about, and there's a really good book called Mind Over Medicine by a lady called Lissa Rankin, which we might have spoken about. L-I-S-S-A, Lissa Rankin, Mind Over Medicine. What I love about her is, she's a medical doctor, and she gives case after case after case of healing happening with the mind, where people think placebos and no-cebos, people getting sick, where they think they're getting something that will make them sick, but it's nothing, they actually make themselves sick. And conversely, people getting well, when they're not actually being given a drug. They're being given nothing, but they think it's something. Even this, and this is fascinating, this operation, pseudo-operation I did with people where—  Lisa: Yeah, I read that one. I read that study. Craig: Amazing. Craig: Oh, yeah, it's look, pain is something that even the people who are experts in it, they don't fully understand. Lisa: Well, I just like, if I can interrupt you there real briefly, because I've been studying what the hell nerve pain, and I'm like, my head, my sores are starting to heal up right. So in my head, I'm like ‘Whoa, I should be having this pain, I'm getting more pain from the burning sensation in my legs and my nerves because it's nerve pain.' So I read somewhere that cryotherapy was good. So in the middle of the night, when I'm in really bad pain, instead of lying there and just losing my shit, and have I now have been getting up every night and having two or three cold ice-cold showers a night, which probably not great for my cortisol bloody profile, but it's, I'm just targeting that leg. That interrupts the pain sensation for a few minutes.  What I'm trying to do as I go, I'm trying to go like, can I—am I getting pain because my brain is now used to having pain? Is it sending those messages, even though there's no need, the sores are healing?  Craig: That is possible. Lisa: Am I breaking? And I can break the pain for about 10 minutes, and then it will come back in again. But I'm continuing on with it, that idea that I can interrupt that pain flow. Then of course, during the breathe in, the meditation, the stuff and sometimes you just lose your shit and you lose it, and then you just start crying, ‘Mummy, bring me some chicken soup' type moments. But it's really interesting. I mean, I just like to look at all these shit that we go from and then say, ‘Well, how can I dissect this and make this a learning curve?' Because obviously, there's something wrong, but I just, I feel for people that are going through years of this. Craig: It's, yeah, I'm the same I feel. Sometimes I work with people, where I work with and as do you, I work with a lot of people who have real problems. I don't have any problems. I mean, they have real problems. And I'm, despite my appearance, I'm quite, I'm very compassionate. It's hard for me because I, it upsets me to see people in pain. I feel simultaneously sad and guilty. How do I deserve this? But it just is what it is. But people like John and a lot of the people that I've worked with and you've worked with, you know, people like that inspire me.  I mean, they're— I don't find typical heroes inspirational. They don't really inspire me like the people we normally hold up as, I mean, well done. I think they're great, but they don't inspire me. People who inspire me or people who really, how the fuck are you even here? How do you turn up? He turns up. He's actually in hospital right now because he's got a problem that's being fixed. But, and he's in and out of hospital all of the time. And then he turns up, he hugs me and he goes, ‘How are you?' I go, ‘I'm good.' He goes, ‘Now look at me.' So I look at him. And he goes, ‘How are you really?' And I go, ‘I'm good.' This is the guy who—  Lisa: Who's dealing with so much. I've got a friend, Ian Walker8, who I've had on the show, too, so he got hit by a truck when he was out cycling, I think it was years and years ago. He ended up a paraplegic. And then he recovered, he didn't recover, he's still in a wheelchair, but he was out racing his wheelchair, he did wheelchair racing, and he's part of our club and stuff. And then he got hit by another truck, now he's a quadriplegic.  This guy, just, he is relentless in his attitude, like he is, and I've seen him dragging himself like with his hands because he's got access now to his hands again. After working for the last couple of years, and he kind of, on a walker frame thing, dragging himself two steps and taking a little video of him, dragging his feet, not the feet out, working, they're just being dragged. But the relentless attitude of the guy, I'm just like, ‘You're a fricking hero. You're amazing. Why aren't you on everybody magazine cover? Why aren't you like, super famous?' Those people that really flip my boat. Craig: Yeah. And I

Is aging a disease? How old does your body say it is? How can we live longer, healthier lives? Dr. David Sinclair, Harvard professor of genetics and bestselling author, joins ISB co-founder and genomics pioneer Dr. Lee Hood for a conversation about the very latest in aging research. David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics, Blavatnik Insitute, and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He has published over 200 scientific papers, is a co-inventor on over 50 patents, and is the New York Times bestselling author of Lifespan. He serves as co-chief editor of the scientific journal Aging. In 2018, he became an Officer of the Order of Australia (AO). Lee Hood, MD, PhD is a world-renowned scientist. Dr. Lee Hood co-founded Seattle’s Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000-2017. In 2016, ISB affiliated with Providence, and Dr. Hood became Providence’s Senior Vice President and Chief Science Officer. He is also Chief Strategy Officer and Professor at ISB. He is a member of the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. Presented by Town Hall Seattle and KUOW. 

I am excited to welcome Melanie Avalon as my guest for today! Melanie is a SAG-AFTRA actress, author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine, host of the top iTunes podcasts The Melanie Avalon Biohacking Podcast, and The Intermittent Fasting Podcast with Gin Stephens, who has appeared on this podcast twice before. Melanie is certified as a wine specialist by the WSET and as a holistic nutritionist by the AFPA. She is a member of MENSA. Melanie developed the top iTunes app, “Food Sense Guide", to help those with food sensitivities, and she currently runs three rapidly growing Facebook groups. Melanie and I became friends when I appeared on her podcast last year, and we have stayed in touch since then. We are doing a biohacking block in April. Throughout April, we will be featuring on the podcast many of the people who I consider to be cutting edge in the biohacking space. Melanie is a powerhouse woman in the intermittent fasting space. She is one of the people helping to change the face of the health and wellness industry. She has no medical training. Yet, she is able to grasp some pretty heavy-duty concepts, and she fully understands the technology behind the various biohacking devices. Melanie is joining us today to talk about some of the biohacking devices and modalities and the benefits you can expect to experience from each of them. So be sure to listen in to find out what she has to say about the benefits of biohacking, supplements, and hormetic stressors. Show highlights: Melanie talks about what biohacking means to her, and she explains where you can start with that. Melanie walks us through the spectrum of biohacking devices, from those she considers milder or more benign to the more intricate ones, and explains what they do. Blue light-blocking glasses were the first biohacking thing that Melanie did. She has never stopped using them. Melanie explains the physical benefits of Near-Infrared Light Therapy and Near-Infrared Light saunas. Cold can do some amazing things for our bodies. We talk about challenging ourselves with hormetic stress and cold therapies. Melanie talks about the benefits of using the Apollo Neuro device for sound wave therapy. Melanie is a reformed insomniac. She discusses what has been the most helpful for her in terms of the quality of her sleep. Melanie talks about supplements that can be helpful for biohacking. The role that NAD+ plays in supporting our energy levels. Melanie talks about Vitamin D and explains why getting enough of it is vital for your health. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website  Connect with Melanie Avalon Follow Melanie on her personal Facebook page, Instagram, and Twitter, join her Facebook Group.            Recommended books: The Wim Hof Method by Wim Hof Lifespan by David A. Sinclair, Ph.D. and Matthew D. LaPlante  Breath by James Nestor The Switch by James W. Clement Recommended app: dminder

Er öldrun sjúkdómur sem er hægt að lækna? Er hægt að koma í veg fyrir algenga öldrunarsjúkdóma og lifa lengur við betri heilsu? Samkvæmt því sem David Sinclair heldur fram í bókinni Lifespan er svarið já. Hann heldur því fram að öldrun sé sjúkdómur sem hægt er að lækna og byggir það á rannsóknarvinnu sem hann hefur verið hluti af í 30 ár og fer meðal annars yfir allt um líffræði öldrunar, hvernig má hægja á öldrun og meira að segja snúa öldrun við. David Sinclair er leiðandi í rannsóknum á öldrun og stýrir meðal annars Department of Aging hjá Harvard Medical School og vinnur við genarannsóknir í átta mismunandi fyrirtækjum sem hann hefur stofnað. Hann á 35 einkaleyfi fyrir uppgvötanir sínar. Tekið upp í Rabbrýminu, Bókasafni Hafnarfjarðar.

¿Quieres escuchar el audiolibro completo? Visita http://www.penguinaudio.com¿Y si envejecer fuera una enfermedad y fuese tratable como tal?El libro escrito por un aclamado científico de la facultad de Medicina de Harvard y una de las personas más influyentes de según Time, que cambiará paradigmas sobre el envejecimiento.El doctor David Sinclair es profesor de genética en la Harvard Medical School y ha sido nombrado por la revista Time como una de las 100 personas más influyentes. Su trabajo ha aparecido ampliamente en los medios de comunicación y ha fundado y codirigido nueve compañías de biotecnología desde 2005. See acast.com/privacy for privacy and opt-out information.

Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals,” changes in the function of our mitochondria, and so many others. Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state. David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan: Why We Age–and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together. In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.  In closing, I really need to say that Lifespan ranks as one of the most influential books I have ever read. Please enjoy today’s interview. To stay current on Dr. Sinclair, follow him on Twitter and Instagram.

On today’s Tank Talk! We welcome our guest Fabrice Grinda, Founding Partner of @ FJ Labs to discuss “Investing in Marketplaces Before It’s A Marketplace”Before starting FJ Labs, Fabrice was an incredibly successful entrepreneur having launched several startups before and after the dot-com bust in early 2000. His first startup Aucland was started by Fabrice at age 23 which grew into one of the largest auction sites in Europe. Next, Fabrice started Zingy in 2001 and grew it to $200 million in sales in four years. After selling Zingy, Fabrice launched OLX or the Online-Exchange as the Craigslist alternative for the world outside the US and grew it to over 300 million monthly unique visitors.On the investing side, Fabrice has over $300 million in exits across 150 companies and has made over 500 angel investments in total, with an impressive track record as an early investor in Alibaba, Lending Club, Delivery Hero and Brightroll among many others.Today you will get to hear Fabrice's tips and tricks on how marketplace startups should tackle challenges. You will hear his thoughts on supply/demand dynamics, SaaS tools in a marketplace, Payment infrastructure and the importance of frequency in building a marketplace.Fabrice’s Book RecommendationsLoonshots - Safi BahcallWhy We Sleep - Matthew Walker, PhDLifespan - Why We Age and Why We Don't Have - David A. Sinclair, PhDFabrice’s words of inspiration - “Whatever you think you can, begin it, boldness is magic and genius to it.”Follow Matt Cohen and Tank Talks here!

There’s more than one way to measure how fast you’re ageing. There’s chronological age - the number of years you’ve been alive - and then there’s biological age, which you can think of as the total damage your body has accumulated over the years. Your chronological age may differ from your biological age, in which case it’s interesting to understand why. The good news is you can reduce your biological age by improving your lifestyle, which in turn can lengthen lifespan and healthspan. The question is, then, how to quantify biological age? On this podcast, NBT Scientific Director Megan Hall talks about PhenoAge: a measure of biological age that can be determined by analyzing a shortlist of common blood markers. We talk about why PhenoAge is important and valid as a reliable measure of biological status, and how you can get your PhenoAge score. Megan also offers tips for improving your PhenoAge once you’ve got your baseline. This episode has a ton of information, so be sure to follow along with Megan’s outline. Here’s the outline of this interview with Megan Hall: [00:00:25] Arden Pope, PhD; Studies on the effects of air pollution on human health. [00:01:15] Puppy update. [00:05:54] Is ageing a disease? Article: Bulterijs, Sven, et al. "It is time to classify biological aging as a disease." Frontiers in genetics 6 (2015): 205.   [00:06:35] Primary vs secondary ageing. [00:08:02] Book: Lifespan: Why We Age - and Why We Don't Have To, by David A. Sinclair PhD. [00:08:16] Ken Ford; STEM-Talk Podcast. Ken Ford on the NBT Podcast: Optimal Diet and Movement for Healthspan, Amplified Intelligence and More. [00:09:19] Measuring ageing. [00:13:09] Theories of ageing - more than 300 theories; Articles: Tosato, Matteo, et al. "The aging process and potential interventions to extend life expectancy." Clinical interventions in aging 2.3 (2007): 401. 2. da Costa, Joao Pinto, et al. "A synopsis on aging—Theories, mechanisms and future prospects." Ageing research reviews 29 (2016): 90-112. 3. Jin, Kunlin. "Modern biological theories of aging." Aging and disease 1.2 (2010): 72.  [00:13:34] Grandmother hypothesis; Podcast: The Postmenopausal Longevity Paradox and the Evolutionary Advantage of Our Grandmothering Life History, with Kristen Hawkes, PhD. [00:14:48] Program Theories and Damage Theories. [00:17:45] Epigenetic clock theory of aging; Steven Horvath; Study: Horvath, Steve, and Kenneth Raj. "DNA methylation-based biomarkers and the epigenetic clock theory of ageing." Nature Reviews Genetics 19.6 (2018): 371.  [00:19:02] Steven Horvath's TEDx talk: Epigenetic Clocks Help to Find Anti-Aging Treatments. [00:20:47] Book: Masters of Doom: How Two Guys Created an Empire and Transformed Pop Culture, by David Kushner. [00:21:43] DNA methylation; Article: Horvath, Steve. "DNA methylation age of human tissues and cell types." Genome biology 14.10 (2013): 3156. [00:23:13] Offspring of semi-supercentenarians have lower epigenetic age; Study: Horvath, Steve, et al. "Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring." Aging (Albany NY) 7.12 (2015): 1159.  [00:23:36] Methylation based biological age associated with: 1.  breast cancer risk: Kresovich, Jacob K., et al. "Methylation-based biological age and breast cancer risk." JNCI: Journal of the National Cancer Institute 111.10 (2019): 1051-1058. 2. Frailty: Breitling, Lutz Philipp, et al. "Frailty is associated with the epigenetic clock but not with telomere length in a German cohort." Clinical epigenetics 8.1 (2016): 21; 3. All-cause mortality: Marioni, Riccardo E., et al. "DNA methylation age of blood predicts all-cause mortality in later life." Genome biology 16.1 (2015): 1-12 and Christiansen, Lene, et al. "DNA methylation age is associated with mortality in a longitudinal Danish twin study." Aging cell 15.1 (2016): 149-154. [00:24:46] PhenoAge as a biomarker of ageing for lifespan and healthspan; Study: Levine, Morgan E., et al. "An epigenetic biomarker of aging for lifespan and healthspan." Aging (Albany NY) 10.4 (2018): 573. [00:29:06] Nine blood markers that make up PhenoAge. [00:29:57] PhenoAge related to COVID-19; Study: Kuo, Chia-Ling, et al. "COVID-19 severity is predicted by earlier evidence of accelerated aging." medRxiv (2020).  [00:30:34] Combining PhenoAge with DNA methylation data as a predictor of mortality. [00:33:28] Episode 59 of HumanOS podcast: Are You Biologically Older or Younger Than Your Chronological Age? [00:33:58] Dr. Josh Turkett’s 4-quadrant model. [00:34:00] Lifestyle factors that accelerate ageing: Sleep: Li, Xiaoyu, et al. "Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis." EBioMedicine 50 (2019): 387-394; Socioeconimic status, childhood and adult adversity: Liu, Zuyun, et al. "Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study." PLoS medicine 16.6 (2019): e1002827; Education: Zhao, Wei, et al. "Education and lifestyle factors are associated with DNA methylation clocks in older African Americans." International journal of environmental research and public health 16.17 (2019): 3141. [00:35:59] Protein; Podcast: Why You’re Probably Not Eating Enough Protein (How to Know for Sure), with Megan Hall. [00:36:50] Book: The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health, by Justin Sonnenburg and Erica Sonnenburg. [00:37:23] Bloodsmart.ai. [00:38:35] Patreon: nbt.link [00:39:33] Age reversal possible in humans? Study: Fahy, Gregory M., et al. "Reversal of epigenetic aging and immunosenescent trends in humans." Aging cell 18.6 (2019): e13028.  [00:40:15] Simon Marshall, PhD. [00:41:00] Interpreting your blood markers to understand PhenoAge. [00:46:11] PhenoAge vs Predicted Age.

Celebrating Science Week 2020 City of Parramatta Libraries will be celebrating National Science Week by providing a diverse range of digital content, catering to all ages and interests that people can experience from home online. The Library has teamed up with scientists, Western Sydney University, an Australian novelist and our library staff. For further information regarding our Science Week program go to cityofparramatta.nsw.gov.au/national-science-week In this podcast one of our Library's 'science enthusiasts' Yan, talks about our programs and some of the interesting science related books she has been reading. Titles discussed in this podcast includes: The telomere effect : a revolutionary approach to living younger, healthier, longer by Elizabeth Blackburn Lifespan : the revolutionary science of why we age - and why we don't have to by David A. Sinclair A woman looking at men looking at women : essays on art, sex, and the mind by Siri Hustvedt

My guest on the show today is David A. Sinclair, Ph.D, a tenured Professor of Genetics at Harvard Medical School, he is best known for his work on genes and small molecules that delay ageing, including the Sirtuins, NAD precursors, Resveratrol and other epigenetic modifiers. He has received many honours including a feature on TIME magazine’s list of the “100 most influential people in the world” and this podcast episode about how to treat and reverse ageing will give you a glimpse into why he is so deserving.On the show we talk about:The hallmarks of ageing and why to distinguish it as a diseaseInstead of trying to tackle each one of the 8 central tenants of ageing, how Prof is looking at the epigenomeSirtuins and their role in ageing, DNA repair and gene expressionAMPK, MTor, Sirtuins as regulators of lifespan and defence pathwaysMethods of fighting ageing and activating the body’s natural defence systemsEnergy restriction, aerobic exercise, sauna and cold shock therapyenergy restriction, exercise triggering hypoxia, sauna, cold shock therapy,NAD and NAD precursors, Metformin, rapamycin and resveratrol as molecules that can improve ageingWhy we need to treat ageing like a disease, which forms the foundation of multiple diseases. If we cure ageing, we cure a lot.The ethical considerations of increasing lifespan Do check out David’s work and his latest book - Lifespan - Why We Age and Why We Don’t Have To.All other social media links are noted here below.YouTubeWebsiteTwitterInstagram See acast.com/privacy for privacy and opt-out information.

In this episode of the Effective Family Office Podcast, host Angelo Robles speaks with David A. Sinclair, Ph.D., A.O. David is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He shares his thoughts on biotech, COVID-19, and longevity.

What if you could reverse the aging process? Sounds like science fiction, but the new science of aging is turning it into science fact. Today, we learn the truth about aging and how to potentially slow, stop and even reverse it from one of the world's leading voices in the science of aging, David A. Sinclair, Ph.D. He is a Professor of Genetics at Harvard Medical School, co-Director of the Paul F. Glenn Center for the Biology of Aging Research at Harvard Medical School, Professor and Head of the Aging Labs at UNSW, Sydney, and an honorary Professor at the University of Sydney. Best known for his work on genes and small molecules that delay aging, including the Sirtuin genes, resveratrol and NAD precursors, he has published over 170 scientific papers, is a co-inventor on over 50 patents, and has co-founded 14 biotechnology companies in the areas of aging, vaccines, diabetes, fertility, cancer, and biodefense. And he's the author of Lifespan: Why We Age and Why We Don't Have To.You can find David A. Sinclair, Ph.D. at: Website | InstagramCheck out our offerings & partners: OMGyes!: The Science of Women's Pleasure. Go to OMGyes.com/goodlife for a special discount.Mint Mobile: To get your new wireless plan for just $15/month, and get the plan shipped to your door for FREE, go to mintmobile.com/goodlife

People that are born today are going to live until they are 130+ years old! How is this possible? How can YOU signal the cells that make up your body to restore themselves and become young again?Aging won't look the same as it did in the 20th century. When we reach 100 years old, we can be full of vitality. This episode is a cup of elixir from the fountain of youth. I found it in David A. Sinclair's groundbreaking work entitled Lifespan: Why We Age―and Why We Don't Have To.

หนังสือ Lifespan: Why We Age—and Why We Don't Have To ของ David A. Sinclair- ยิ่งเรามีอายุมากเท่าไร เราก็ยิ่งมีโรคมากเท่านั้น- การที่พยายามมีอายุที่ยืนมากยิ่งขึ้น ไม่เป็นประโยชน์ในทางการแพทย์- คนที่อายุยืนเพราะมีสาเหตุมาจากพันธุกรรม และปัจจัยเสริมคือชีวิตประจำวัน- อัตราการเต้นหัวใจก็บ่งบอกถึงความสั้นยาวของอายุได้แม่นยำพอสมควร- ทั้งนี้การที่จะมีอายุยืนได้ หรือมีชีวิตที่สมบูรณ์อาจจะไม่ใช่สิ่งเดียวกันเสมอไป

In der neuen Folge des Podcasts haben wir mit Marco Alberti über die Herausforderungen beim Einsatz von OKRs gesprochen und darüber, wie deren Wirkung im Unternehmen gezielt gemessen werden kann. Johannes Müller zu Gast bei Murakamy's Podcast zu Murakamy Marco's Buchempfehlung: Lifespan - David A. Sinclair

Episode 157 giving you some insides of my lifestyle crazy work that leads to one hour to 4 hours of the eating pattern but going back to my 72 hours of fasting once a month. Are you down? Join me Fasted Human links https://instagram.com/fastedhuman https://Facebook.com/FastedHuman Join the group https://www.facebook.com/groups/819712998397223/?ref=share Get you 14 Days Free Trial Now For Beachbody On Demand https://www.beachbodyondemand.com/register?referringRepId=64947&term=3 I've been using the LIFE app to track my Intermittent Fasting. Join my fasting circle! https://lifefastingtracker.app.link/oWKF54bWS3 Be Part of the Fasting News Group https://www.facebook.com/groups/fastingnews/?ref=share I'm listening to Lifespan by David A. Sinclair PhD,Matthew D. LaPlante, narrated by David A. Sinclair PhD on my Audible app. Try Audible and get it here: https://www.audible.com/pd?asin=1508296057&source_code=ASSORAP0511160006 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/FastedHuman/support

Through his extensive research, Dr. David A. Sinclair believes that we can slow down and even reverse aging.“Aging is a disease, and that disease is treatable.”Those are the words of Dr. David A. Sinclair, in his book, Lifespan: Why We Age―and Why We Don't Have To. Through his extensive research, Dr. Sinclair believes that we can slow down and even reverse aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.It's not even just about feeling younger, we can actually become younger. Dr. Sinclair joins Dr. Roizen to share insights from the book and explain some of the latest breakthrough discoveries in the science of longevity. Want better health and nutrition? Now you can get personalized supplement recommendations and custom vitamin packs delivered to your door! Go to PersonaNutrition.com/Roizen and take your free assessment and get 50% off your order today. - sponsor   BonusCould You Have a Heart Attack and Not Know It?

Through his extensive research, Dr. David A. Sinclair believes that we can slow down and even reverse aging.“Aging is a disease, and that disease is treatable.”Those are the words of Dr. David A. Sinclair, in his book, Lifespan: Why We Age―and Why We Don't Have To. Through his extensive research, Dr. Sinclair believes that we can slow down and even reverse aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.It's not even just about feeling younger, we can actually become younger. Dr. Sinclair joins Dr. Roizen to share insights from the book and explain some of the latest breakthrough discoveries in the science of longevity. Want better health and nutrition? Now you can get personalized supplement recommendations and custom vitamin packs delivered to your door! Go to PersonaNutrition.com/Roizen and take your free assessment and get 50% off your order today. - sponsor   BonusCould You Have a Heart Attack and Not Know It?

David A. Sinclair, Ph.D., is one of the world's most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him "one of the 100 most influential people in the world" (2014) and among the "Top 50 People in Healthcare" (2018). New York Times Bestselling author of Lifespan: Why We Age―and Why We Don't Have To.David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you'd most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world's top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab's discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing--and what that means for humanity going forward.He's applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results-- which, it should be noted, are completely anecdotal--are encouraging. He's now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award.- https://lifespanbook.com/Catch my book - Screw Being Shy, March 14th on my website markmetry.comPlease do NOT hesitate to reach out to me for any reason on LinkedIn, Instagram, via email mark@vudream.com, text me 508-925-0261!LinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast

David A. Sinclair, Ph.D., is one of the world's most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him "one of the 100 most influential people in the world" (2014) and among the "Top 50 People in Healthcare" (2018). New York Times Bestselling author of Lifespan: Why We Age―and Why We Don't Have To.David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you'd most likely find him hanging out in his lab at Harvard Medical School, where he's a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world's top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He's also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab's discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he's been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing--and what that means for humanity going forward.He's applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results-- which, it should be noted, are completely anecdotal--are encouraging. He's now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award.- https://lifespanbook.com/Catch my book - Screw Being Shy, March 14th on my website markmetry.comPlease do NOT hesitate to reach out to me for any reason on LinkedIn, Instagram, via email mark@vudream.com, text me 508-925-0261!LinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast

What if you could slow down the clock on your aging? According to aging expert and Harvard geneticist, Dr. David Sinclair, we now have the knowledge and technology to live longer lives, healthier. In his revolutionary research, Dr. Sinclair has identified mechanisms behind aging giving us clues into the behaviors and molecules that can potentially extend life.  Listen and Learn: Why is aging a disease and how can it be slowed What are longevity genes and what role do they play in health What is epigenetics and how does it relate to aging and health What is hormesis and why is being too comfortable bad for our longevity What behavioral strategies can you start today that will lead to a longer life What molecules Dr. Sinclair’s lab is researching that could be our future fountain of youth What are the social and individual impacts of living longer with more health What does Dr. David Sinclair do each day to activate his longevity genes Resources: Lifespan: Why we age and why we don’t have to by David Sinclair The Harvard Study of Adult Development About David Sinclair David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the TIME magazine’s list of the “100 most influential people in the world”.

Recently we’ve had remarkable guests on the podcast highlighting areas of evolutionary mismatch. It’s clear our society has disconnected from real food and good sleep, but we’ve also detoured from what’s optimal in how we congregate, educate, and support one another. We’ve divided ourselves into nuclear families, often leaving our children in the care of strangers so we can go to a job we don’t care about, in order to earn money to pay for our segregated lifestyle. Social isolation has become so common we barely realize the madness of it - until we need help and find that there’s no one nearby. In this interview, I’m joined by my wife, food scientist Julie Kelly to talk about how our society could benefit from a cohousing model, transcending the current paradigm that leaves parents exhausted and young adults unable to afford housing. We discuss our own living situation and that of neighbours and friends, many of whom could benefit from living with others to share resources and skills. We’re in the contemplation stage of actually doing something about this, and would love to hear from you about experiences you’ve had - good or bad! - with cohousing or communal living.  Here’s the outline of this interview with Julie Kelly: [00:00:34] Podcast: Civilized to Death: Are We Really Making Progress? with Christopher Ryan. [00:01:07] Stephanie Welch podcasts 1. Disruptive Anthropology: An Ancestral Health Perspective on Barefooting and Male Circumcision (she discusses the concept of nuclear family at the 55:13 minute mark), 2. The Need for Tribal Living in a Modern World, focusing more exclusively on cohousing. [00:03:07] Whole 30. [00:03:52] Book: The Story of the Human Body: Evolution, Health, and Disease, by Daniel Lieberman. [00:05:08] Book: Lifespan: Why We Age―and Why We Don't Have To by David A. Sinclair, PhD. [00:05:46] STEM-Talk Podcast: Episode 98: Steven Austad talks about aging and preserving human health.   [00:05:46] Blue zone fraud; Study: Newman, Saul Justin. "Supercentenarians and the oldest-old are concentrated into regions with no birth certificates and short lifespans." bioRxiv (2019): 704080. [00:06:22] Book: Mothers and Others: The Evolutionary Origins of Mutual Understanding, by Sarah Blaffer Hrdy. [00:07:08] Alloparents. [00:13:00] Attachment theory. [00:26:42] Podcast: How to Optimise Your Gut Microbiome, with Lucy Mailing. [00:30:59] Book: Delivering Happiness: A Path to Profits, Passion, and Purpose, by Tony Hsieh. [00:33:40] Podcast on unschooling: How to Support Childhood Cognitive Development, with Josh Turknett, MD. [00:36:00] Podcast: How to Live Well in a High Tech World, with Cal Newport. [00:37:31] Strategies and tactics of cohousing. [00:39:45] Contact me if you have experience with cohousing: chris@nourishbalancethrive.com. [00:42:30] Patreon; Forum thread on cohousing. [00:42:48] Cohousing resources: Why Denmark dominates the World Happiness Report rankings year after year; Pocket Neighborhoods; The New Generation of Self-Created Utopias; My working cohousing Google doc. [00:43:15] Podcast: A Statin Nation: Damaging Millions in a Brave New Post-health World, with Malcolm Kendrick. [00:47:19] Starcity. [00:49:56] Grandmother hypothesis. [00:54:05] Cooperative breeding. [00:58:07] Book: Mindset: The New Psychology of Success by Carol Dweck. [00:58:12] Book: Radical candor: Be a Kick-Ass Boss Without Losing Your Humanity, by Kim Scott. [01:01:08] Book: Chop Wood Carry Water: How to Fall in Love with the Process of Becoming Great, by Joshua Medcalf. [01:01:39] Podcast: Ketones for Performance, Cognition, and Cardiovascular Health, with Brianna Stubbs, PhD. [01:03:18] Book: The Evolution of Everything: How New Ideas Emerge, by Matt Ridley. [01:06:05] Podcast: Building Compassionate Communities to Improve Public Health, with Julian Abel, MD.

Se você é homem e já passou dos 50 anos, descubra uma forma de restaurar biologicamente o corpo masculino para firmeza, desejo, músculos e energia - https://alaindutra.com/jolivi-virilidade Se você acompanhar esse vídeo até o final você vai conhecer algumas das principais teorias sobre o envelhecimento e o que um dos principais estudiosos sobre o assunto faz pessoalmente para reverter o processo. Curso Dr. Alain - O Código da Virilidade - https://alaindutra.com/jolivi-virilidade Livro - David A. Sinclair PhD - https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/1501191977 Link Vídeos Epigenética: https://www.youtube.com/watch?v=2XnTSQBX3C8 e https://www.youtube.com/watch?v=thjVVDRuKSU Responda a pesquisa e ganhe toneladas de material gratuito imediatamente: http://alaindutra.com/pesquisa Para ter acesso ao conteúdo exclusivo descrito nesse vídeo faça parte do grupo de apoiadores clicando no link: https://alaindutra.com/apoio Para assinar a lista de emails: https://alaindutra.com/lista Conheça meu site e blog: https://alainuro.com OU http://alain.med.br Minhas redes sociais: http://instagram.com/dralaindutra http://fb.com/dralaindutra Link de atalho ao meu canal do Youtube: http://alainuro.com/canal Email: alain@alainuro.com Por favor se inscreva no canal e deixe seu comentário.

Through his extensive research, Dr. David A. Sinclair believes that we can slow down and even reverse aging.“Aging is a disease, and that disease is treatable.”Those are the words of Dr. David A. Sinclair, in his book, Lifespan: Why We Age―and Why We Don't Have To. Through his extensive research, Dr. Sinclair believes that we can slow down and even reverse aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.It's not even just about feeling younger, we can actually become younger. Dr. Sinclair joins Dr. Roizen to share insights from the book and explain some of the latest breakthrough discoveries in the science of longevity. Want better health and nutrition? Now you can get personalized supplement recommendations and custom vitamin packs delivered to your door! Go to PersonaNutrition.com/Roizen and take your free assessment and get 50% off your order today. - sponsor   BonusCould You Have a Heart Attack and Not Know It?

David A. Sinclair David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. In this episode, you'll discover: 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity. 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger. 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period. 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock. 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type. 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water. 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more. 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease. 01:06:19 - How older mice that were given nicotinamide mononucleotide experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose had improved mitochondrial function and enhanced physical performance. 01:01:22 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits. And so much more!   If you're interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/david-sinclair Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. In this episode, we discuss... 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity. 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger. 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period. 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock. 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type. 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water. 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more. 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease. 01:06:19 - How older mice that were given nicotinamide mononucleotide experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose had improved mitochondrial function and enhanced physical performance. 01:01:22 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits. And so much more! Click here to get this episode's show notes and transcript Watch this episode's highlights on the FMF Clips channel Get early access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started. Submit your raw genetic data to get the latest version of the genetic report at foundmyfitness.com/genetics.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging. Time stamps:   9:35 Start of podcast.  10:53 Does when you eat matter more than what you eat? 12:48 Time restricted feeding and longevity. 17:04 What causes us to age? 20:05 What cellular information is being lost? 26:35 What Causes DNA break? 28:47 DNA breaks as clastogenesis. 29:32 Food and DNA breaks  31:28 PARP enzymes. 34:57 NAD 40:15 NAMPT 42:35 Nicotinamide and sirtuins. 44:25 Methylation and methyl groups. 45:44 Sirtuins. 48:11 Heat/cold and sirtuins/NAMPT 52:54 What do sirtuins do with ADP ribose. 56:15 Role of active sirtuins. 58:25 Other longevity genes. 1:04:30 Importance of mitochondrial NAD levels. 1:05:50 Ketosis and NAD. 1:11:20 Resveratrol. 1:14:45 Xenohormesis and plant molecules- my view vs David’s 1:19:55 Resveratrol trials, concerns about resveratrol. 1:26:05 mTOR 1:31:37 David's plant based diet- and why it could be better 1:38:10 Meat consumption and the environment 1:45:35 Where to find David's stuff. 1:47:20 The most radical thing David has done recently.  David’s contact info: https://genetics.med.harvard.edu/sinclair/people/sinclair.php https://lifespanbook.com/ Instagram: @davidsinclairphd Twitter: @davidasinclair My info   PATREON: https://www.patreon.com/paulsaladinomd   Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   Use CARNIVORE15 for 15% off special deals this week at info.whiteoakpastures.com/carnivoremd    JOOVV: www.joovv.com/paul   Native: For 20% off your first purchase, visit nativedeodorant.com and use promo code SALADINO during checkout! INSIDER: carnivoremd.com   My contact information:   SOCIAL MEDIA  Instagram: @carnivoremd Website: carnivoremd.com Twitter:@carnivoremd  Facebook: Paul Saladino MD email: drpaul@carnivoremd.com Stay Radical!  

Die Vorstellung, ewig zu leben, fasziniert Menschen seit Urzeiten. Bislang blieb diese Vision ein Wunschtraum, doch Wissenschaftler arbeiten daran, sie zu verwirklichen. Wie nah sie ihrem Ziel sind, beschreibt der Harvard-Genetiker David A. Sinclair in seinem neuen Sachbuch. Rezension von Martin Hubert www.deutschlandfunk.de, Forschung aktuell Hören bis: 19.01.2038 04:14 Direkter Link zur Audiodatei

Book: LIFESPAN "Why We Age And Why We Don't Have To" By: David A. Sinclair PhDTry fasting...just 24 hoursIt's NEVER TOO LATE, TAKE ACTION!

David A. Sinclair, Ph.D., co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, has been listed in TIME magazine's “100 most influential people in the world” (2014), and appeared on their list of the "Top 50 in Healthcare" (2018). Dr. Sinclair is best known for his work into anti-aging and longevity, putting forth the idea that aging is a disease and we can uncover the tools to put it into remission. His book "Lifespan: Why We Age - and Why We Don't Have To" is a New York Times Bestseller. Full show notes: Dr. Sinclair|Mind-Jam Podcast

Episode #22 - A short overview on the book “Lifespan” Part Two  My name is Theresa Skrobanek and this is the “My Aging And Wellness” Podcast. This Podcast is about aging well, feeling well, and looking great while doing it! I hope to make it okay to age and to bring you the bright side of aging. Please check out my Youtube channel @ Just a woman aging and you can find me on Instagram @ myagingandwellness and on Facebook @ https://www.facebook.com/MYAGINGANDWELLNESS and at myagingandwellness.com The links for the products in this episode: The book Lifespan by David A. Sinclair   (https://amzn.to/2nowzgP) For interviews or to contact me, you can email me @ theresaskrobanek@yahoo.com Get on the "Wound & Repair Your Skin Blueprint" where I show you exactly how to wound your skin in a controlled manner and then let it heal to create beautiful and younger looking skin

Episode #21 - A short overview on the book “Lifespan”   My name is Theresa Skrobanek and this is the “My Aging And Wellness” Podcast. This Podcast is about aging well, feeling well, and looking great while doing it! I hope to make it okay to age and to bring you the bright side of aging. Please check out my Youtube channel @ Just a woman aging and you can find me on Instagram @ myagingandwellness and on Facebook @ https://www.facebook.com/MYAGINGANDWELLNESS and at myagingandwellness.com The links for the products in this episode: The book Lifespan by David A. Sinclair   (https://amzn.to/2nowzgP) For interviews or to contact me, you can email me @ theresaskrobanek@yahoo.com Get on the "Wound & Repair Your Skin Blueprint" where I show you exactly how to wound your skin in a controlled manner and then let it heal to create beautiful and younger looking skin

When it comes to anti-aging research, Dr. David A. Sinclair of Harvard Medical School is on the forefront of research and innovation. He joins on episode 231 to discuss his new book Lifespan: Why We Age – and Why We Don’t Have To. Dr. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and … Continue reading "231: David A. Sinclair | Anti-Aging Research And Understanding In “Lifespan”" The post 231: David A. Sinclair | Anti-Aging Research And Understanding In “Lifespan” appeared first on The Armen Show.

In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease.  We discuss: How and why David moved from Australia to Leonard Guarente’s lab at MIT [7:30]; Sirtuins and aging [15:00]; A series of experiments elucidating the mechanisms of sirtuins [20:45]; How are sirtuins activated? [25:30]; NAD and sirtuin activation [31:00]; Nicotinamide, sirtuin inhibition, andPNC1 [39:00]; Resveratrol [43:00]; The NIH/ITP studies on resveratrol [55:45]; Does David take any compounds for longevity? [1:00:15]; NAD precursors (NR, NMN) and pterostilbene [1:02:45]; Female fertility and NAD precursors [1:14:45]; A unifying theory of aging [1:20:30]; Waddington’s epigenetic landscape [1:23:00]; If David had unlimited resources, what is the experiment he would do? [1:28:25]; Testing combinations to extend lifespan [1:31:30]; What made David aware of his mortality at such a young age? [01:33:45]; What is David’s book going to cover? [01:37:15]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Radical Candor™ is the ability to Challenge Directly and show you Care Personally at the same time. Radical Candor will help you and all the people you work with do the best work of your lives and build the best relationships of your career. Two nearly universal experiences make Radical Candor unnatural. One, most people have been told since they learned to talk some version of “if you don’t have anything nice to say, don’t say it at all.” When they become a boss, the very thing they have been taught not to do since they were 18 months old is suddenly their job. Furthermore, most people, since they got their first job, have been told to be “professional.” Too often, that’s code for leaving your humanity at home. But to build strong relationships, you have to Care Personally. You have to bring your whole self to work. Buy Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity. Here’s the outline of this podcast with Dr Tommy Wood: [00:00:29] Mastermind Talks. [00:01:04] MMT Guests: Ben Greenfield & Dave Asprey. [00:01:53] Carmel Valley Ranch. [00:02:55] Jayson Gaignard [00:05:51] Belgian Waffle Ride. [00:06:11] Lesley Paterson & Simon Marshall at Braveheart Coaching. [00:07:23] Book: Radical Candour by Kim Scott. [00:07:44] Chart. [00:08:51] Obnoxious aggression. [00:10:55] Shit sandwich. [00:11:21] Book: The Hard Thing About Hard Things: Building a Business When There Are No Easy Answers by Ben Horowitz. [00:12:24] Kim Scott. [00:16:06] Viome CEO, Naveen Jain. [00:17:10] Catchbox. [00:17:39] Transcriptome. [00:18:08] Interview: Type 2 Diabetes, Fasting, Your Questions Answered with Dr Jason Fung. [00:18:46] Interview: Why We Get Fat and What You Should Really Do About It with Chris Masterjohn, PhD and Tommy Wood, MD, PhD. [00:19:41] Absentee hatchet job. [00:20:28] Interview: The Migraine Miracle with Dr Joshua Turknett. [00:21:34] Video: The Most Reliable Way to Lose Weight with Chris Masterjohn, PhD. [00:23:23] Article: Should Calorie Counting Be the Main Focus for Somebody Trying to Lose Weight (Body Fat)? by Tommy Wood, MD, PhD. [00:24:20] Tommy's Dad on PubMed. [00:25:09] Flat tire. [00:26:11] STEM-Talk podcast: Gary Taubes discusses low carb diets and sheds light on the hazards of sugar. [00:27:27] Manipulative insincerity. [00:31:33] IFM talk on insulin Buck Institute. [00:33:21] Book: Surely You're Joking Mr Feynman by Richard P Feynman. [00:34:04] Paper: Dominique Chretien, Paule Benit, Hyung-Ho Ha, Susanne Keipert, Riyad El-Khoury, Young-Tae Chang, Martin Jastroch, Howard Jacobs, Pierre Rustin, Malgorzata Rak. “Mitochondria Are Physiologically Maintained At Close To 50 C”. [00:36:25] Paper: Cronise, Raymond J., David A. Sinclair, and Andrew A. Bremer. "Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease." Metabolic Syndrome and Related Disorders (2016). Be sure to read Tommy’s response: Wood, Thomas. "If the Metabolic Winter Is Coming, When Will It Be Summer?" Metabolic Syndrome and Related Disorders (2017). [00:41:48] Slack, Torea Rodriguez. [00:44:51] Discourse forum software.

My guests this week are two of the brightest minds in the health and fitness industry. The first is my own Chief Medical Officer, Tommy Wood, MD PhD. Tommy is currently working as a visiting scientist researching neonatal brain injury at the University of Washington. He received his undergraduate degree in Biochemistry from the University of Cambridge, before studying medicine at the University of Oxford. My second guest is Chris Masterjohn, PhD. Chris earned his PhD in Nutritional Science from the University of Connecticut at Storrs, where he studied the role of glutathione and dietary antioxidants in regulating the accumulation of methylglyoxal. He has authored or co-authored ten peer-reviewed publications. His writes a blog, The Daily Lipid, and produces a podcast by the same name. You can also follow his professional work on Facebook, Twitter, Instagram, YouTube, and Snapchat (whatever that is!). Tommy’s premise for this interview was as follows: If you fix lifestyle and environment, can you be a lot less "strict" with your diet? For instance, are low carbers needing to be so low carb because everything else is broken? I took that idea and invited Chris Masterjohn on to the show for a roundtable discussion that starts with a general debate on the causes of obesity and then moves on to what we can all to improve or maintain our body composition. You should listen to this interview because unlike many others I’ve heard; it includes a broad discussion of the range of issues that we see in our practice that hold people back from their body composition goals. The first time you meet someone who plateaued in their weight loss while eating a low-carb diet you realise that it’s a bit more complicated than that. Here’s the outline of this interview with Tommy Wood and Chris Masterjohn: [00:03:15] "The built environment," one that facilitates eating more and moving less. [00:07:48] You, the listeners, are already winning! [00:08:38] The composition of our food. [00:09:32] Upsetting set points--poor sleep. [00:09:57] Circadian rhythm. [00:10:07] Stress and gut health. [00:11:36] Low-carb diets and weight loss. [00:11:52] Cronise, Raymond J., David A. Sinclair, and Andrew A. Bremer. "Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease." Metabolic Syndrome and Related Disorders (2016). Be sure to read Tommy’s response: Wood, Thomas. "If the Metabolic Winter Is Coming, When Will It Be Summer?." Metabolic Syndrome and Related Disorders (2017). [00:12:58] Most of your stored body fat came from the fat that you ate. [00:13:28] Calorie restriction. [00:14:14] Insulin increases carbohydrate oxidation. [00:19:10] Body recomposition programs. [00:19:49] Chris Masterjohn does not see insulin as a key player. [00:20:37] Whenever you restrict food choices, food intake goes down. [00:22:56] MyFitnessPal. [00:23:08] Sleep and calorie intake. [00:24:28] Low-carb doesn't work well for the type of exercise Chris Masterjohn does. [00:26:37] Preparing for fat-loss. [00:29:53] Starting with other ideas that don't work can be helpful. [00:32:47] Fueling for your activity. [00:33:56] Start by fixing your environment. [00:34:26] Feasting and fasting. [00:35:14] Whole foods. [00:38:32] Reduced activity in obesity is a symptom, not a cause. [00:40:33] We're designed to eat when there's an abundance of food, i.e. the summer [00:41:22] Dr. Satchin Panda on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health. [00:42:58] Light differential--go outside! [00:46:05] Blue light at night. [00:47:01] Ben Greenfield talks about the Human Charger. [00:47:35] Desktop lights, e.g. Light Book Edge. [00:50:01] Lindqvist, P. G., et al. "Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort." Journal of internal medicine 280.4 (2016): 375-387. [00:55:17] Checklists before testing. [00:58:22] Picture of metabolism and motivation for change. [00:59:20] Daily Lipid podcast. [00:59:45] The Ultimate Vitamin K2 Resource. [01:02:18] Chris is now offering consultation packages. [01:02:41] Recruiting for a human study. [01:05:18] Gary Vaynerchuk. [01:07:42] Developing new tests, especially for vitamin K2. [01:09:21] VitaK. [01:11:17] Tommy's plans for the future. [01:12:26] Dr Pedro Domingos: How to Teach Machines That Can Learn. [01:12:42] Book a free consultation with NBT.