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In this episode, Babafemi Taiwo, MBBS, discusses new HIV data from IAS 2021, including:WHO Global Clinical Platform: COVID-19 outcomes in PWH2-drug regimen of DTG/3TC: efficacy, metabolic outcomes (TANGO)Investigational antiretroviral useCAB LA + RPV LA in treatment-naive PWH (FLAIR)Investigational antiretroviral agentsLEN (CAPELLA, CALIBRATE)ISL (P011, P016)Alternative BPaL dosing in treatment of drug-resistant TB (ZeNix)Babafemi Taiwo, MBBSGene Stollerman Professor of MedicineChief, Division of Infectious DiseasesNorthwestern University Feinberg School of MedicineChicago, IllinoisContent based on a CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP.; Merck Sharp & Dohme Corp; and ViiV Healthcare.Follow along with an expanded slideset at: https://bit.ly/3syWD5TLink to full program: https://bit.ly/3z8SBnC
Jaye Espy specializes in Diversity Partnerships in education — specifically helping students connect, access, and prepare for industry. As Founder and Principal of 353, LLC, her work with diverse corporate, education, and non-profit clients has focused on issues that impact the education ecosystem.As an experienced strategic thought partner who has worked as an implementation specialist across the education spectrum, Jaye has managed complex projects to improve P16 education systems across the United States. She started Mississippi's first virtual public school in 2002 through a U.S. Department of Education grant and was also a part of the founding team to launch washingtonpost.com in 1995. Jaye's current work covers a wide range of education areas across equity and access, workforce development, and partnership opportunities for schools, teachers, and students at Stride Learning, an online learning service. Jaye's portfolio also includes consulting with Codehouse, a non-profit that aims to tackle the diversity gap in technology and Black Tech Ventures, a company that empowers the next generation of black student innovators to become tech entrepreneurs. Jaye formerly served as chief of staff for the White House Initiatives on HBCUs for the Obama Administration where she led collaborative partnership teams across federal, corporate, and post-secondary institutions to improve opportunities for students and faculty, especially in computer science. She was also a special assistant in the Office of the Deputy Secretary. She also worked with UNCF, College Board, Association Montessori International, Mississippi Department of Education, Accenture, and Deloitte. Jaye has degrees from Howard University and the University of Mississippi and is extremely active in politics in her home state of Mississippi and as a Maryland resident.
The 'low rake vs. high rake' chatter seems like a thing of the past. Mercedes seem to have found their way around the rule changes for 2021 and regained the 'title favourites' tag from Red Bull Racing. And of course, Lewis Hamilton delivering superlative performances race after race. After claiming his 100th pole position in Spain, Hamilton went on to claim his 98th win in Formula 1. His win was a lethal mix of race strategy + overtaking. Yes, it was Hungary 2019 all over again! (The episode description follows after the promotional messages) Use 'PUMAINSIDELINE' to avail a 5% discount on Puma's Motorsport merchandise collection (exclusive for our listeners in India). A special contest is coming up for the 2021 Monaco Grand Prix. Follow our social media profiles to play and win. #F1 #Merchandise For our global audiences, get 20% OFF at Manscaped + free Shipping with promo code TRIMINSIDE at MANSCAPED.com! #ad #manscapedpod Subscribe to our newsletter! It's free, informative, insightful and visually appealing. You can read more and sign up. In this Pits to Podium segment of the Inside Line F1 Podcast, Soumil and Kunal discuss if Red Bull Racing could have acted differently to Mercedes' strategic play in the 2021 Spanish Grand Prix. Pierre Gasly's P16 to P10 in the last stint, Charles Leclerc's fine fourth and battle with Valtteri Bottas, Perez-Ricciardo's race-long fight for P5. Did Mercedes and Red Bull Racing make an error each in race strategy? Will Red Bull missing a 'second driver' in the battle of strategy headline for one more season? And of course, more mid-field chatter as we look back at the 2021 Spanish Grand Prix. Tune in! Follow our hosts on Twitter: Soumil Arora and Kunal Shah Music courtesy: Lucien Byfieldt Image courtesy: Mercedes AMG Petronas
Did Howard Stelzer break the Noisextra crew with "The Acrid Acme (of)" P16.D4? Stelzer brought us this unclassifiable CD from 1989 to explore. This album has been with him since it’s release, and Howard’s knowledge and relationship with this seminal German project is infectious. We also get into Stelzer’s discovery of noise while living in Florida in the late 80s/early 90s.
FIA's time penalties have always evoked extreme reactions from fans. At the 2020 Russian Grand Prix, reigning World Champion Lewis Hamilton joined the party. Are the FIA really trying to slow 'him' down? If anything, the FIA were fair in their assessment of Hamilton-Mercedes' infringements. In fact, they were fair in treating Leclerc-Stroll as a racing incident, too. And of course, Daniel Ricciardo's reaction to his time penalty was delightful! In this Pits To Podium (https://bit.ly/pitstopodium) segment, Soumil and Kunal wonder if victory in the 2020 Russian Grand Prix was Valtteri Bottas' easiest career win till date? In a straight fight between the two Mercedes drivers, Bottas (medium) could've taken the lead of the race from Hamilton (soft) had the race run its regular course. However, given that this win was 'gifted' to Bottas thanks to Hamilton's penalty, his post-race radio message did seem strange. Another strange statistic? Max Verstappen scoring his and Red Bull Racing's first-ever podium at Sochi. Carlos Sainz Jr.'s embarrassing opening lap crash, Sergio Perez's fourth place finish in the older spec Racing Point package, Ricciardo's phenomenal pace and Lerclerc's spirited drive - some of the key talking points from the 2020 Russian Grand Prix. Sebastian Vettel's thirteenth place finish, behind GIO and MAG - AND him being used as a wingman for LEC's fight against the Renaults. And finally, the battle for P16 between the Twitch stars - Albon, Norris and Russell. Relive the key moments of the 2020 Russian Grand Prix in this episode. Tune in! (Season 2020, Episode 48) Follow our hosts on Twitter: Soumil Arora (https://twitter.com/iamsoumilaroraa) and Kunal Shah (http://www.twitter.com/kunalashah) Music courtesy: Lucien Byfieldt (https://lucienbyfieldt.bandcamp.com/) Image courtesy: Mercedes
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.17.158279v1?rss=1 Authors: Barnett, S. J., Dong, R., Briggs, L., Moushey, A., Li, A. Abstract: It has been established that an overactive orexin (OX) system is associated with neurogenic hypertension in spontaneously hypertensive rats (SHRs). However, the chronology and mechanism of such association between orexin system and hypertension is unclear. We hypothesized that an aberrant surge of OX neurons in SHRs precedes the aberrant increase of arterial blood pressure (ABP) during postnatal development, which was primarily contributed by the exaggerated postnatal OX neurogenesis. We found that (1) SHRs experienced a greater surge in the number of orexin neurons than normotensive Wistar41 Kyoto (WKY) rats before P16, which led to significantly more OX neurons than age42 matched controls by P15-16 (3680+/-219 vs 2407+/-182, respectively, P=0.002). (2) Exaggerated OX neurogenesis, marked by bromodeoxyuridine (BrdU), was the primary contributor to excessive OX neurons in SHRs during development. (3) In contrast, SHRs and normotensive control rats have similar mean arterial blood pressure (ABP) at P15, and a significantly higher ABP in SHR than WKY emerges at P20 (74.8 +/- 2.5 vs 66.9 +/- 4.4 mmHg in wakefulness, respectively, P
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.20.106930v1?rss=1 Authors: Salter, E. W., Lei, G., Choi, S.-L., Ralph, L. T., Zhang, L., Jin, F., Kadia, A., Wang, J., Georgiou, J., Collingridge, G. L. Abstract: The complement cascade is an innate immune pathway that, in addition to host defense against pathogens, actively maintains tissue homeostasis. Complement is necessary for synaptic pruning during development and drives aberrant synapse loss in a number of neurodegenerative disorders that affect the hippocampus. However, the physiological function of complement in hippocampal synapse development is unknown. To address this, we investigated C3-/- mice at P16-18. We found that VGLUT2+ synapses were increased in the CA1 stratum lacunosum moleculare (SLM) and dentate gyrus molecular layer (DGML) of C3-/- mice compared to wildtype. Conversely, VGLUT1+ synapses, inhibitory synapses and myelin were not affected in the CA1 stratum radiatum (SR), SLM or DGML of C3-/- mice. Finally, we found that there was a decrease in microglial phagocytic activity only in VGLUT2+ regions and this correlated with the amount of VGLUT2+ synapses. Our study elucidates a role of the complement cascade in regulating hippocampus synapse number with exceptional specificity for VGLUT2-containing synapses during development. Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.05.077784v1?rss=1 Authors: Meng, X., Yu, Y., Kao, J., Kanold, P. O. Abstract: Cortical layer 1 (L1) contains a diverse population of interneurons which can modulate processing in superficial cortical layers but the intracortical sources of synaptic input to these neurons and how these inputs change over development is unknown. We here investigated the changing intracortical connectivity to L1 in primary auditory cortex (A1) in slices of mouse A1 across development using laser-scanning photostimulation. Before P10 L1 cells receive most excitatory input from within L1, L2/3, L4 and L5/6 as well as the subplate. Excitatory inputs from all layers increase and peak during P10-P16, the peak of the critical period. Inhibitory inputs followed a similar pattern. Functional circuit diversity in L1 emerges after P16. In adult, L1 neurons receive ascending inputs from superficial L2/3 and subgranular L5/6, but only few inputs from L4. A subtype of L1 neurons, NDNF+ neurons, follow a similar pattern, suggesting that transient hyperconnectivity is a universal feature of developing cortical circuits. Our results demonstrate that deep excitatory and superficial inhibitory circuits are tightly linked in early development and might provide a functional scaffold for the layers in between. These results suggest that early thalamic driven spontaneous and sensory activity in subplate can be relayed to L1 from the earliest ages on, that the critical period is characterized by high transient columnar hyperconnectivity, and that in particular circuits originating in L5/6 and subplate might play a key role. Copy rights belong to original authors. Visit the link for more info
Long-time educator, Karla Weatherly, has gone from kindergarten teacher at Bivins Elementary to the head of the Texas Panhandle P-16 Council at ESC Region 16 since she met Anette as the kindergarten teacher of Anette's oldest son, Walker. Karla has worn a variety of educator hats in this time, and has never strayed far from her early childhood beginnings. Now she connects those to college completion through her work on the P-16 council, and here shares her expertise across all educational levels. Thanks, Karla! Learn about becoming a teacher, or filling out the FAFSA! Karla covers it all!
Human rights watch to PH gov't: Hunt down Maguindanao massacre suspects at largeDuterte to troops: Crush New People's Army, other enemies of stateTrump accuses dDemocrats of 'attempted coup'Ride-hailing firm Grab slapped with P16-m fine
Doug, P16, and Puddle get a visit from FlexOn, a Crumb guy who’s real happy to see them…or is it FlexOff, who’s a…real lonely guy? Either way, I was going to listen to this earlier but WE WERE ON A BREAK! Meanwhile, the Professor and Danica stop for a much needed Yerg-style meal.FlexOn/FlexOff- Tim FeltonDoug Doyle- Connor DoyleP16- Ryan ClearyPuddle- Sarah MagnusonProfessor Barnabus- James FreetlySpecial Agent Danica Patrick, No Relation- Liz AndersonArtwork by Blair Britt
P16 sat on the tape recorder and caused some technical difficulties on this one, y’all! He’s real sorry! Meanwhile, the HR boys get a visit from Liff Niff, who may have just accidentally duplicated himself, and MAY have some lovin’ feelings about it. Also, the Professor and Danica mourn their beloved Wade.Liff Niff- Chris GeorgeDoug Doyle- Connor DoyleP16- Ryan ClearyAlien Beercan- Peter WilliamsProfessor Barnabus- James FreetlySpecial Agent Danica Patrick, No Relation- Liz AndersonArtwork by Blair Britt
Whooa, a bonus episode! Let’s take a trip back to yesteryear, when P16 was still a closeted robot trying to eat lunch with some other robot buddies…P16- Ryan ClearyJeff the Proctor-Bot- Connor DoyleDave the Janitor-Bot- James FreetlyXR90 the Cashier-Bot- Patrick BodenhausenArtwork by Blair Britt
Learn how to the following phrases in Mandarin Chinese: My last name is... His last name is... Her last name is... For the lesson notes, please visit: http://ChineseMandarinCafe.com/P16 [ Newsletter] The best place to stay connected is through my newsletter You will receive free learning resources, and you will be the first to receive any updates! Subscribe to the newsletter here: http://ChineseMandarinCafe.com/sub3 [ Chinese Mandarin Cafe Podcast Season 1 Early Bird Podcast Listener ] http://ChineseMandarinCafe.com/season1 Please note that this is an ongoing Podcast show! I will be releasing one new episode per week. By enrolling in this course, you will be an Early Bird Podcast Listener You will receive access to Lesson Notes for Season 1 (10 Lesson Episodes) and discounts for future Chinese Mandarin Cafe products. Your support will help me tremendously as a solo creator Thank you! [ About Your Host ] Hello! I am Amy Lin. I am an online 1-on-1 language teacher and a language learner
P16 throws his party, revelations are revealed, and Season One ends. We're surprised we made it this far, too.Griff the Otter- Damon RoysterBilly the Raccoon- Surena MariePuddle- Sarah MagnusonDorphoidal McGuire- Scott PiebengaBloodpuncher the Space Marine- James D'AmatoFancy Hat- Danny GalvinCarmony Chupp Chupp- Ben HarpeDoug Doyle- Connor DoyleP16- Ryan ClearyAlien Beercan- Peter WilliamsProfessor Barnabus/Captain Drew Butt- James FreetlyWade Anderson- Patrick BodenhausenSpecial Agent Danica Patrick, No Relation- Liz AndersonArtwork by Blair Britt
Dr D'Souza talks to ecancertv at IAOO 2015 about the role of HPV in head and neck cancer and how it varies across different countries in the world. The studies consolidated tumour samples, risk factor survey information and survival information in order to centrally test for P16 and HPV16 DNA, two biomarkers that show if a tumour is HPV related.
Our favorite Puddle comes back to the HR Department! Let's see if that latent sexual tension between her and P16 can turn into latent comedy on this comedy podcast. Meanwhile, let's check back in with Wade, Danica Patrick No Relation, and the Professor, because that plot isn't at ALL convoluted now, right?Puddle the puddle- Sarah MagnusonDoug Doyle- Connor DoyleAlien Beercan- Peter WilliamsP16- Ryan ClearySpecial Agent Danica Patrick, No Relation- Liz AndersonProfessor Barnabus- James FreetlyWade Anderson- Patrick BodenhausenArtwork by Blair Britt
Wade and Danica Patrick, No Relation promise they'll write, but camp's gotta end for everybody, right? Doug, Alien, and P16 celebrate SpaceFest, the holiday where you get drunk and tell secrets. Well, the holiday where you officially get drunk and tell secrets. The boys reveal some real bombshells. Let's see if they can save their bacon.Doug Doyle- Connor DoyleAlien Beercan- Peter WilliamsP16- Ryan ClearySpecial Agent Danica Patrick, No Relation- Liz AndersonIntern Wade Anderson- Patrick BodenhausenArtwork by Blair Britt
With Michelle and the Professor at the bottom of Giza Falls, who will introduce us to episodes and plug things?? Meet Special Agent Danica Patrick, No Relation, and Wade Anderson, Intern. They're...more competent I think? Doug, Alien, and P16 are visited by Dale Isringhausen, a pile of gas, who knows all, I think? Hoo baby, this bit is really hitting...I think?Dale Isringhausen- Spencer RybackiDoug Doyle- Connor DoyleAlien Beercan- Peter WilliamsP16- Ryan ClearySpecial Agent Danica Patrick, No Relation- Liz AndersonIntern Wade Anderson- Patrick BodenhausenArtwork by Blair Britt
Doug, Alien, and P16 are visited by Carmony Chupp Chupp, who is trying to make the best possible symphony of all time (until next year) and also decide if his boss is cat-phish-ing him. Michelle and the Professor dig up their ol' buddy Escape Pod, and...well...let's just say some season finale type stuff goes down, except this isn't a season finale, because this is a podcast, you idiot.Featuring:Carmony Chupp Chupp- Ben HarpeDoug Doyle- Connor DoyleAlien Beercan- Peter WilliamsP16- Ryan ClearyProfessor Barnabus- James FreetlyMichelle K. Branch- Phoebe StonebrakerArtwork by Blair Britt
Michelle and the Professor and in deep doodoo now. Deep desert walking, held at gunpoint, non-sexy blindfold wearing doodoo. Doug, Alien, and P16 get a visit from the mysterious Captain Drew Butt, who is...uhh...well, let's just say mentally unstable doesn't really cover it.Featuring:Captain Drew Butt/Professor Barnabus- James FreetlyDoug Doyle- Connor DoyleAlien Beercan- Peter WilliamsP16- Ryan ClearyMichelle K. Branch- Phoebe StonebrakerArtwork by Blair Britt
Michelle and the Professor assure you that everything is TS-A-Okay with them. Doug, Alien, and P16 spacewalk the boards with an other-world-class thespian. Put on your government issued spacesuits, there's lots of worlds out there!Featuring:Fancy Hat- Danny GalvinDoug Doyle- Connor DoyleAlien Beercan- Peter WilliamsP16- Ryan ClearyProfessor Barnabus- James FreetlyMichelle K. Branch- Phoebe StonebrakerArtwork by Blair Britt
P5. Mrs. Brice had twenty-five mice. 布莱斯太太有25只老鼠。 P6. She fed her mice the finest cheese. 她用最好的奶酪来喂养她的老鼠。 P7. She washed and dried them behind their ears, so they were always clean. 她经常给老鼠们洗澡并把他们的耳后擦干,所以老鼠们总是非常干净。 P8. Mrs. Brice loved to sing for them. When she played the piano, twenty-four little mice danced around her. 布莱斯太太很喜欢为老鼠们唱歌。 当她弹钢琴的时候,24只小老鼠围着她跳舞。 P9. One very small mouse danced on top of her hand. He was afraid to fall between the keys. 一只非常小的老鼠在她手背上跳舞,却又害怕掉进琴键间。 P10. When Mrs. Brice went to bed, twelve little mice slept on one side of her. Twelve little mice slept on the other side. One very small mouse slept on the clock, in case he wanted to know what time it was. 当布莱斯太太躺床上睡觉时, 0 00 12只小老鼠睡在她一侧,12只小老鼠睡在她另一侧, 非常小的那只小老鼠睡在时钟上,免得他不晓得时间。 P11.In the morning, Mrs. Brice did exercises. She stretched her arms and legs. She bent over and touched her toes with her fingers. 清晨,布莱斯太太做运动。 她伸展胳膊和腿,她弯腰,用手指触碰足尖。 P12.“One, two, three, four, five, six.... One, two, three, four, five, six ....” “1,2,3,4,5,6......1,2,3,4,5,6......” P13.Twenty-four little mice did exercises too. 24只小老鼠也跟着做运动。 P14. They streched, they bent, 他们做伸展运动,他们弯腰 P15. they touched their toes. One very small mouse kept on sleeping. 碰碰自己的足尖。 非常小的那只小老鼠还在睡觉。 P16. “It it time for our walk,” said Mrs. Brice. Twelve little mice walked in front of her. Twelve little mice walked in back. One very little small mouse sat on top of Mrs. Brice hat, so he could see where they were going. P17. He saw a cat. P18. Twelve little mice ran this way. Twelve little mice ran that way. P19. One very small mouse jumped down to the ground and ran this way and that. P20. He ran so many different ways, the cat got tired of chasing him and went back. to whatever he had been doing. P21. “What a clever little mouse you are,” said Mrs. Brice. “Now we can go to buy some food.” P22. Twenty-four little mice sat in a cart and enjoyed the ride. One very small mouse sat in front. P23. They went up one aisle. P24. They went down another. P25. Mrs. Brice bought food in cans, food in jars, cold food, hot food. P26. “Now we can go home,” said Mrs. Brice. Twenty-four little mice were glad. But one very small mouse kept on leading the way. He led them to the dairy counter. P28. Mrs. Brice bought a nice, big cheese. P29. Then she and her mice went home to eat it. P30. After they ate, Mrs. Brice sang and played the piano. P31. Twenty-four mice danced around her. P32. One very small mouse kept right on eating.
In Part 2 of 2 videos about squamous lung cancer, Dr. Chad Pecot explains the value of patients receiving molecular profiling of their tumor, the vital role of clinical trials, and the promise of immunotherapy for treating this type of lung cancer.
In Part 2 of 2 videos about squamous lung cancer, Dr. Chad Pecot explains the value of patients receiving molecular profiling of their tumor, the vital role of clinical trials, and the promise of immunotherapy for treating this type of lung cancer.
In Part 2 of 2 videos about squamous lung cancer, Dr. Chad Pecot explains the value of patients receiving molecular profiling of their tumor, the vital role of clinical trials, and the promise of immunotherapy for treating this type of lung cancer.