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We had the chance to catch up with Mike Wheeler. We talked about letting the songwriting process happen organically, the therapeutic aspect of songwriting, and music as an all-inlifestyle. We also visited a little bit about Bertha Grateful Drag that he plays with. Mike Wheeler is a singer-songwriter originally hailing from Vermont. With stintsin Montreal, New Zealand, Augusta, GA, Key West, Colorado, Wisconsin, and Kentucky-- where he was called "hands down, one of the finest WKY singer-songwriters going at the moment" (News4U, 2017)-- Wheeler now calls Nashville home. Mike's debut LP, Roll Another Dime, produced by Grammy-winning studio engineer, RobEaton, was released by Pacific Records in March of 2022. The record features appearances by Adam Chaffins, Todd Smallie, Rob Eaton Jr., and Sierra Ferrell. He is hoping to release 2 albums in 2025! In recent years, Mike has performed at Newport Folk Festival, CaveJam, & Sea Hear Now as a member of BERTHA: Grateful Drag, as well as Folk Alliance International, ROMP,Maverick Festival (UK), Dark Songs, Aiken Bluegrass Festival, The Frendly Gathering,IBMA: World of Bluegrass, Steelbridge Songfest, and countless clubs, pubs,living rooms, and dives, paving his grassroots DIY. Check Mike out here: Website: https://www.mike-wheeler.net/home Bandcamp: Mic Wheeler FB: Michael James Wheeler IG: Micwheeler
Gabe Morency has you covered for another edition of SportsRage. First - Ric Serritella jumps in to talk NFL draft and tanking teams. Who will the Raiders and Giants take in the draft, and could we see Ewers potentially return to Texas or transfer? They also break down top non-qb prospects in the draft and where they could wind up. After, Loud Esmond is in the mix for bowl season with their best bets. Finally - Cam joins Gabe and Loud to preview bowl games and the CFB playoffs.
Jaden and Paul recap the UK v WKY game and sit down with 96 Champion Oliver Simmons for a chat about Pope, this years team and what it was like in 96. Also, Casey makes his first appearance on the live show. Sponsored by: State Line Co (statelineco.shop) X: @StateLineCoPromo Code: BleedBlue for 10% off purchase
Opposite of The Burns and Allen Show at 9PM, NBC ran a special “Cross Country D-Day tour”, hosted by the just-heard Ben Grauer. It was a program from every part of the nation to show what everyone was thinking and doing on this historic and momentous day. The theme was the same: Work, Pray, Fight. The stations included remotes from WTIC in Hartford, WSYR in Syracuse, WTAR in Norfolk, WSPD in Toledo, WLW in Cincinnati, WMC in Memphis, KTSP in St. Paul, and WKY in Oklahoma City.
Program #15. NBC net, WKY, Oklahoma City origination. "Spawn Of The Subhuman". "The nation's favorite soprano makes an airplane flight to an incredible destiny that awaits her at the hands of a strange and mysterious madman. + The nation's favorite soprano star makes an aeroplane flight to an incredible destiny, which awaits her at the hands of a strange and mysterious madman…
Welcome to the Halloween Special presented by New West Radio Theatre. For the next few weeks, until the thirty first of October, we will present two very mysterious, very dark tales from the past.Tonight you will hear stories from the radio show "Dark Fantasy".Dark Fantasy was an American radio supernatural thriller anthology series. It had a short run of 31 episodes, debuting on November 14, 1941, and ending on June 19, 1942. Its writer was Scott Bishop, also known for his work on The Mysterious Traveler. It originated from station WKY in Oklahoma City and was heard Friday nights on NBC stations. The stories found a nationwide audience almost immediately.And now two tales from "Dark Fantasy".The stories tonight were fromOld Time Radio Player - Mobile Software Design, LLCFor More Information, Contact New West Radio Theatre At:newwestradiotheatre@gmail.com
This time on Ron's Amazing Stories we have a collection of your stories with the loose theme of the Skinwalker. There are five of them, all sent in by you for you. We review the audiobook Murder by Other Means which is book two of The Dispatcher. Our featured story comes from the OTR series Dark Fantasy. It is a creepy one with a few twists and turns, and there might even be a volcano. So press that play button and enjoy the show. Featured Story - The Thing From The Sea Our featured story comes from the old time radio archives of Dark Fantasy. This was a series dedicated to dealings with the unknown. It originated from radio station WKY, Oklahoma City, and it was written by Scott Bishop. Our story today is one of those. It is titled The Thing From The Sea. A newspaper reports on cinema star Philip Haywood vanishing from his private yacht. Where did he go? This one first aired in November of 1941. Other Stories Include - Snake Bite At The X-Bar Ranch, Murder by Other Means, The Incidents, The Black Dog, On Their Back Legs, The Coyote, The Wiggler, and The Thing From The Sea Ron's Amazing Stories Is Sponsored by: Audible - You can get a free audiobook and a 30 day free trial at and - Good Treats for your dog to eat. Your Stories: Do you have a story that you would like to share on the podcast or the blog? Head to the main website, click on Story Submission, leave your story, give it a title, and please tell me where you're from. I will read it if I can. Links are below. Program Info: Ron's Amazing Stories is published each Thursday. You can download it from , stream it on or on the mobile version of . Do you prefer the radio? We are heard every Thursday at 10:00 pm and Sunday Night at 11:00 PM (EST) on . Check your local listing or find the station closest to you at this . Social Links: Contact Links:
Local reaction to Trump's third indictment, a look at what makes Western Kentucky unique, and a look inside the National Quilt Museum in Paducah.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550350v1?rss=1 Authors: Tosta, A. S., Fonseca, A. S., Messeder, D., Siqueira, P., Ferreira, S. T., Lourenco, M. V., Pandolfo, P. Abstract: Attention deficit hyperactivity disorder (ADHD) is characterized by inattention, hyperactivity and impulsivity, and develops most frequently during childhood and adolescence. Spontaneously hypertensive rats (SHR) are the most used experimental model for the study of ADHD. SHR exhibit behavioral impairments that recapitulate phenotypes observed in individuals with ADHD. SHR further develop dopaminergic hypofunction in frontostriatal circuits and an imbalance in dopamine and norepinephrine systems. Maternal physical exercise (e.g., swimming) during pregnancy has been shown to promote angiogenesis, neurogenesis, learning, and memory in the offspring of control rats. We investigated the impact of gestational swimming on behavioral and dopaminergic parameters in childhood (1-2 weeks of age) and adolescent (4-5 weeks of age) SHR and Wistar Kyoto rats (WKY), used as a control. Maternal gestational swimming resulted in a reversal of neurodevelopmental impairments in behavior, assessed by the righting reflex and olfactory recognition tests, in the offspring. Furthermore, during adolescence, SHRs from exercised dams exhibited reduced novelty seeking, an important behavioral trait in this developmental period. Finally, SHRs exhibited increased expression of dopamine transporter (DAT) and D2 receptors (D2R) in the frontal cortex. D2R expression was normalized in the frontal cortex of adolescent SHRs whose mothers were exercised. Results suggest that physical exercise during pregnancy could be an effective preventative strategy against ADHD-associated behavioral and neurochemical phenotypes in the offspring. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Gov. Beshear tours flood damage in Western Kentucky, a fire damages Sen. Rand Paul's Bowling Green office, lawmakers are briefed on forever chemicals in drinking water, staffing remains an issue at the state's youth detention centers, and a Kentucky chef who is now a well-known TV cooking expert.
For those who remember the television show “Shindig!” but may have forgotten the host, this story will remind you of the very talented Jimmy O'Neill, who was from Enid, Oklahoma.He started his radio career at 16 in Enid, then on to WKY Oklahoma City and KQV Pittsburgh before making his Los Angeles debut at the brand-new KRLA in 1960. The station had just adopted a top-40 format.At the age of 20, Jimmy O'Neill had the most popular program in his time slot, making him the youngest person ever to have a No. 1 show.Jimmy was 24 when he hosted “Shindig!” which was on ABC television from September 1964 to January 1966 and for a time ran twice a week. Besides the Beatles, among its list of superstars, “Shindig!” featured the Who, the Rolling Stones, Sam Cooke, the Beach Boys, and the Righteous Brothers.Jimmy was also the owner of Pandora's Box, an influential Sunset Strip music venue in West Hollywood, California.Jimmy eventually left Los Angeles for KOB in Albuquerque, New Mexico, and then WOW, Omaha, Nebraska, where John Erling worked with him at WOW and KOIL.Jimmy was 73 when he died January 11th, 2013. For Jimmy's story, John interviewed Jimmy's former wife Eve O'Neil, whose brother was actor Troy Donahue.If you search the web for Jimmy O'Neill, you'll find examples of his extraordinary work. Listen to the Jimmy O'Neill story on the oral history website and podcast VoicesofOklahoma.com.
Dark Fantasy was a short series with tales of the weird, adventures of the supernatural, created for you by Scott Bishop. The series aired as a horror drama on NBC between 1941 and 1942. Dark Fantasy was a series dedicated to dealings with the unknown. Originating from radio station WKY, Oklahoma City, it was written by Scott Bishop and was heard Fridays over stations. Tom Paxton served as announcer. The shows covered horror, science fiction and murder mysteries. Although a short series, the shows are excellent with some stories way ahead of their time. This is a production of the Old Time Radio Researchers (OTRR) Group located at Old Time Radio Researchers Website (www.otrr.org), Old Time Radio Researchers Facebook Group, and Old Time Radio Researchers Group. It contains the most complete and accurate version of this series in the best sound possible at the time of creation. An updated version will be issued if more episodes or better sounding ones become available.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.04.522787v1?rss=1 Authors: Aydin, A. G., Adiguzel, E. Abstract: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders of childhood, characterized by locomotor hyperactivity, impaired sustained attention, impulsivity, and distractibility. Recently, the dysfunction of different synaptic circuits in the prefrontal cortex (PFC) has been shown. Previous studies have attributed the pathophysiological mechanism of ADHD to disturbances in the dopaminergic system. In this study, we tested the hypothesis that spontaneously hypertensive rats (SHR), which are considered a validated animal model of ADHD, have altered dopaminergic innervation and increased locomotor activity. Here, we performed immunohistochemical tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) staining. The mesocortical dopaminergic system appears to be normal in juvenile SHR, as suggested by (i) no alteration in the area density of TH-immunoreactive (TH-ir) dopaminergic neurons in the VTA, (ii) no alterations in the volume density of TH-ir fibers in layer I of the PrL subregion of mPFC, (iii) no alteration in the percentage of TH-ir dopaminergic fibers in layer I of the PrL subregion of mPFC as revealed by TH and/or DBH immunoreactivity. Furthermore, the SHR showed increased locomotor activity than WKY in the open field test. The demonstration of no alteration in mesocortical dopaminergic neurons and fiber in SHR raises some concern about the position of SHR as an animal model of the inattentive subtype of ADHD. However, these results strengthen this strain as an animal model of hyperactive/impulsive subtype ADHD for future studies that may elucidate the underlying mechanism mediating hyperactivity and test various treatment strategies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
The OTR Now Radio Christmas #006 The Burns and Allen Show. December 23, 1936. CBS net, KHJ, Los Angeles aircheck. Sponsored by: Campbell's Soup, Schaeffer Pen (local). The cast does Gracie's version "A Christmas Carol." Gracie sings, "I Love You From Coast To Coast." The program is also known as, "The Campbell's Tomato Juice Program." George Burns, Gracie Allen, Ken Niles (announcer), Henry King and His Orchestra, Tony Martin. The Greatest Story Ever Told. December 21, 1947. ABC net. "No Room At The Inn". A very well-done story of the Nativity. The fourth of a series of five Christmas dramas. The script was subsequently used on the program on December 23, 1951, December 21, 1952, December 20, 1953, December 19, 1954, December 25, 1955, December 30, 1956. This recording might be from one of these dates. Norman Rose (narrator).The Bill Stern Colgate Sports Newsreel. December 21, 1945. Program #319. NBC net. Colgate Shave Cream. Bill Stern, Ezra Stone. 15 minutes. Audio Condition: Excellent. Complete.Gunsmoke. December 23, 1956. CBS net. "Beeker's Barn". Sponsored by: L & M, Chesterfield. A young couple take shelter in her estranged father's barn, just before she has a baby! The script was used again on the series on December 20, 1959 (see cat. #44630). The system cue is added live. William Conrad, Les Crutchfield (writer), Parley Baer, Ralph Moody, Vic Perrin, Virginia Gregg, Georgia Ellis, Howard McNear, Norman Macdonnell (producer, director), John Meston (editorial supervisor), Rex Koury (composer, conductor), Ray Kemper (sound patterns), Tom Hanley (sound patterns), George Fenneman (announcer), George Walsh (announcer). Dark Fantasy. December 26, 1941. Program #6. NBC net, WKY, Oklahoma City origination. "The House Of Bread". Sustaining. A writer of supernatural stories (who happens to be named "Bishop") searches for, "The Truth." A man named "Word" advises to search for, "The House Of Bread." A truly "fantastic" Christmas story. The script runs long and ends just in time. Scott Bishop (writer, host). 25:03. Audio Condition: Excellent. Complete.The Campbell Playhouse. December 24, 1939. CBS net. "A Christmas Carol". Sponsored by: Campbell's Soup. The definitive version of the classic story. Barrymore never was better. Charles Dickens (author), Lionel Barrymore, Orson Welles (producer, introducer), George Coulouris, Bea Benaderet, Ray Collins, Everett Sloane, Frank Readick, Bernard Herrmann (composer, conductor).SOURCES: Wikipedia and The RadioGoldindex.com
Aaron, Doug and a returning Nato cover Christmas coming a bit early for WKY tornado survivors, charter school shenanigans in NKY, and we learn more about what the crowded GOP Governor's primary might look like. Then we discuss the state of union and labor organizing and why sick days are such a big deal with Blue Collar Writer and friend of the show Matt Alley. Finally, we wrap up with an important call to action. SHOW NOTES News of the Weak: https://www.wnky.com/beshear-1000-checks-to-be-mailed-to-insured-homeowners-who-benefitted-from-fema/ https://www.wkms.org/housing/2022-12-09/beshear-sites-for-rebuilding-flooded-eastern-kentucky-communities-being-considered https://twitter.com/linknky/status/1602702469607428097?s=42&t=USva1QxacLIwCcTn__HuDg https://linknky.com/news/education/2022/12/12/explainer-what-does-a-charter-school-authorizer-do/ https://www.thecentersquare.com/kentucky/teachers-group-files-ethics-complaint-against-kentucky-lawmaker-after-charter-school-bill-vote/article_64a32216-aedc-11ec-88c2-1f5dd28a4528.html https://www.kentucky.com/news/politics-government/article269945382.html Interview: Blue Collar Writer, Matt Alley https://www.teepublic.com/user/bluecollarwriter https://www.bluecollarwriter.com/ Call to Action: Support the Warrior Met coal miners - out on strike for their SECOND year https://umwa.org/umwa2021strikefund Episode produced by Annabel Nagel #ProgressKentucky - #ColonelsOfTruth Join us! http://progressky.org/ http://bit.ly/joinproky Support us! http://bit.ly/supportproky Live Wednesdays at 7pm https://www.facebook.com/progressky/live/ Facebook @progressky Instagram @progress_ky Twitter @progress_ky YouTube http://bit.ly/progress_ky Music from www.NatoSongs.com Logo and some graphic design provided b ywww.couchfiremedia.com
Dark Fantasy is our first entry for September, let's enjoy their fifth episode titled, Men Call Me Mad. This episode aired Friday, December 19, 1941. Story: A scientist, in his lab, tells that he's found worlds exist within worlds. Projecting how he's found tiny people in a moonbeam proves the theory. His new potion will make him smaller. Small enough to eventually join the moonbeam world. Broadcast on NBC Radio on WKY in Oklahoma City. Dark Fantasy had a short run of only 31 episodes, debuting on November 14, 1941, and ending on June 19, 1942. : : : : : My other podcast channels include: MYSTERY x SUSPENSE -- DRAMA X THEATER -- COMEDY x FUNNY HA HA -- VARIETY X ARMED FORCES -- THE COMPLETE ORSON WELLES . Subscribing is free and you'll receive new post notifications. Also, if you have a moment, please give a 4-5 star rating and/or write a 1-2 sentence positive review on your preferred service -- that would help me a lot. Thank you for your support. https://otr.duane.media/ (https://otr.duane.media) | Instagram https://www.instagram.com/duane.otr/ (@duane.otr)
Western Kentucky has some amazing distilleries. In this episode we review the latest offerings from three of our favorite WKY producers including Muhlenberg Kentucky Bourbon from Bard Distillery, Barker's Mill from MB Roland and Wheated KY Straight Bourbon from Casey Jones.Spoiler: All three are winners. #CaseyJonesDistillery https://www.caseyjonesdistillery.com/#BardDistillery https://thebarddistillery.com/#MBRolandDistillery https://mbroland.com/
On this episode I chatted with Lee Allan Smith, formerly known as Mr Oklahoma City. Lee's philosophy "have many friends" Oklahoma native Lee Allan Smith graduated from the University of Oklahoma and began his career in radio and television production as a salesman when he joined Gaylord Broadcasting Company's WKY Radio/TV. He eventually became president and general manager of KTVY (formerly WKY and currently KFOR) television. Smith produced the Stars and Stripes Show, which was televised nationally and often featured Bob Hope and a cast of celebrities and national sports figures. He was the project chair for the building of Aquaticus at the Oklahoma City Zoo and as president of Oklahoma Centennial Sports, Inc., brought the U.S. Olympic Festival to Oklahoma in 1989. Smith launched the “Festival of the Horse” in 1990, and only a year later the event was named among the top 100 attractions in North America. Known as “Mr. Oklahoma City,” Smith is president of OK Events, was named “Oklahoman of the Year” in 1990, presided over the grand re-opening of Oklahoma City's Civic Center Music Hall in 2001 and was co-chairman of Oklahoma's 2007 Centennial Events. This episode is presented by the Oklahoma Hall of Fame, telling Oklahoma's story through it's people since 1927. For more information on the Oklahoma Hall of Fame go to www.oklahomahof.com and definitely follow them on instagram for daily updates www.instagram.com/oklahomahof #thisisoklahoma
Dark Fantasy is our first entry for June, let's enjoy their episode titled, The Demon Tree. This episode aired December 5, 1941. Broadcast on NBC Radio on WKY in Oklahoma City. Story: a strange forest with an even stranger tree, that some say can strangle people if they enter the forest. Fanciful legend or fact? Starring: Eleanor Naylor Corin and Ben Morris. Dark Fantasy had a short run of only 31 episodes, debuting on November 14, 1941, and ending on June 19, 1942. : : : : : https://otr.duane.media/ (https://otr.duane.media) | email: info@otr.duane.media Instagram: https://www.instagram.com/duane.otr/ (@duane.otr) | Twitter: https://twitter.com/duane_otr (@duane_otr) It's 100% free to subscribe & you'll receive new post notifications. Also, if you have a moment, please give a 4-5 star rating and/or write a 1-2 sentence positive review on your preferred service -- that would help me a lot. Thank you for your support.
Aaron, Nate & Kimberly cover what the General Assembly has been up to the past week or so as well as some more useful actions from our Governor - millions in federal investments in clean water projects thanks to Joe Biden's American Rescue Plan funding. Kimberly brings us the news we need in under 5 minutes - then we talk with Bruce Maples, publisher of Kentucky's progressive media platform (& our new content partner) Forward Kentucky. Call to Action: Send email to your KY lawmaker: https://bit.ly/StandingWithAndy Sign our petition:https://bit.ly/InvestigateDrPaul Join our campaign: http://bit.ly/joinproky Events calendar: Kentucky Center for Economic Policy Annual Conference Jan 21 https://kypolicy.org/kypolicy-conference-2022/ KFTC Virtual Lobby Day for a Healthy Democracy Jan 25 https://www.mobilize.us/kftc/event/420385/ Fairness Rally Feb 16 https://Fairness.org/Rally Donate to grassroots recovery for WKY tornados: https://actionnetwork.org/fundraising/kentucky-tornado-relief/ Sources: Story 1: https://www.kentucky.com/news/politics-government/article257436617.html https://www.vox.com/future-perfect/2018/10/16/17928164/early-childhood-education-doesnt-teach-kids-fund-it Story 2: https://governor.ky.gov/BetterKy/ https://www.epa.gov/newsreleases/epa-announces-112643000-water-infrastructure-projects-kentucky# Stories Under 5: GOP MLK Hypocrisy: https://www.facebook.com/progressky/photos/a.112760890348229/455758959381752/ John Yarmuth calls it: https://twitter.com/RepJohnYarmuth/status/1483086766911508483?s=20 https://www.leoweekly.com/2022/01/a-state-lawmaker-wants-to-force-kentucky-sports-teams-to-play-the-national-anthem/ https://www.wdrb.com/news/tsa-confiscates-3x-amount-of-guns-at-louisvilles-airport-in-2021/article_cf7b73ec-7960-11ec-8b21-4b98aa060264.html https://hoptownchronicle.org/kentucky-senate-adopts-assisted-living-reforms/ https://www.wpsdlocal6.com/news/mcconnell-announces-465-million-to-complete-the-kentucky-lock-and-dam-project/article_54a164c2-795d-11ec-bce9-a349f8655d3c.html Support us! http://bit.ly/supportproky Live Wednesdays at 7pm https://www.facebook.com/progressky/live/ Facebook @progressky Instagram @progress_ky Twitter @progress_ky YouTube http://bit.ly/progress_ky The Jones Report - Sundays at 7PM Facebook - @TheJonesReportRadio Music from www.NatoSongs.com Logo and some graphic design from http://couchfiremedia.com
A one-month hiatus was too long, but a lot has happened in WKY. Neal and Ed briefly discuss Murray State men's and women's basketball, the silence of MVC expansion chatter, Ja Morant, Cameron Payne, Quincy Williams and a whole lot more. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/ftwinquired/support
Aaron, Doug and Kimberly revisit the terrible tornado tragedies that hit Western Kentucky last week - looking at the best and the worst of humanity that showed up in the twister's 230 mile long track - Doug brings us a few bills that have been pre-filed in Frankfort for the upcoming general assembly & Kimberly Cecil-Jones covers news we need to know - in under 5 minutes! Then, the Colonels welcome Carrie Ray with the Mountain Association and discuss how federal infrastructure programs could help communities struggling with high energy costs. SHOW NOTES: Worst of WKY response: https://www.kentucky.com/news/local/crime/article256718872.html https://www.kentucky.com/news/local/crime/article256686797.html Best: https://www.kentucky.com/news/state/kentucky/article256722662.html https://www.kentucky.com/news/state/kentucky/article256726952.html https://www.kentucky.com/news/politics-government/article256789527.html Bad Bills on Tap in Frankfort: https://apps.legislature.ky.gov/record/22rs/prefiled/prefiled.html https://www.wnky.com/scholars-talk-critical-race-theory-and-proposed-bill-69-in-kentucky-schools/ Rep Reginald Meeks to retire - prompting special election: https://www.wlky.com/article/special-election-date-set-to-fill-seat-of-longtime-kentucky-state-rep-reginald-meeks/38574320 WKY Tornado relief donations: https://actionnetwork.org/fundraising/kentucky-tornado-relief/ https://secure.kentucky.gov/formservices/Finance/WKYRelief Guest: Carrie Ray, the Mountain Association https://mtassociation.org/ https://www.kentucky.com/opinion/op-ed/article256453901.html The Jones Report, relaunching in 2022: Sundays at 7PM Facebook - The Jones Report Radio Program Progress Kentucky music from www.NatoSongs.com Logo and some graphic design provided by www.couchfiremedia.com
Bowl Week continues through this week into the next with most top-tiered bowl games yet to transpire. Bailey Zappe put on a record breaking performance in WKY's win over App State, passing for 6 TDs. In further news, the football living legend Tom Brady has unveiled his new brand which will premiere in the new year. Along with the unveiling of his brand, he also began signing athletes to NIL contracts to promote the brand; One of them being Michigan's own Cade McNamara. Tune in.Follow us on Twitter! @ginpros#GINPROSLIVE STREAM SCHEDULE: VARIABLE: Follow Social Media Outlets!@gincommish - John J. II@ginanalytics - Cody AlmasyFIND THE GIN & TONIC SERIES HERE - https://www.youtube.com/channel/UCTAcezOkWmUotUyAK1CzE_QTRILLNESS AFFILIATES - https://dipwadic.webs.com/affiliates @ginsportsnetwork - Main@ginpros - Twitter@ginpromotions - Parent IGNational Problem Gambling Helpline: 1-800-522-4700www.linktr.ee/ginpros www.ginpros.orgwww.facebook.com/ginproswww.patreon.com/ginpros GIN PROS. 2021
Aaron and Doug look at the aftermath of the horrible WKY tornado, and discuss the Mayfield Consumer Products candle factory decisions, climate's role in the disaster, the politics of the President's visit and Rand's rescue hypocrisy. We also share how people can help the most vulnerable communities, and then welcome Mayfield native and good-trouble-maker Berry Craig, who spent time in his now-unrecognizable hometown, and helped welcome President Biden to town. #ColonelsOfTruth #ProgressKentucky Donate to WKY Communities: The Governor has launched Team Western Kentucky Tornado Relief Fund https://secure.kentucky.gov/formservices/Finance/WKYRelief KCET, Hood to the Holler, others supporting grassroots groups focused on vulnerable communities https://actionnetwork.org/fundra.../kentucky-tornado-relief/ Mayfield Consumer Products: This candle company isn't smelling so great right now. https://wfpl.org/mayfield-candle-factorys-labor-practices-under-scrutiny-in-wake-of-deadly-tornado/ Climate signal in the tragedy: https://www.bbc.com/news/59641376 Interview: Berry Craig https://news.yahoo.com/opinion-tornados-took-mayfield... https://forwardky.com/a-photo-gallery-from-mayfield/ Other donation and volunteer opportunities The Jones Report: Sundays at 7PM on Facebook -The Jones Report Radio Program Music from www.NatoSongs.com Logo and some graphic design provided by www.couchfiremedia.com
This month on Episode 24 of Discover CircRes, host Cindy St. Hilaire highlights the topics covered in the May 14th Compendium on Heart Failure, as well as discussing two original research articles and a brief overview of the Review Series on Calcific Aortic Valve Disease from the April 30th issue of Circulation Research. This episode also features an in-depth conversation with Dr David Durgan and Huanan Shi from Baylor School of Medicine about their study Restructuring The Gut Microbiota by Intermittent Fasting Lowers Blood Pressure. Article highlights: Vacante, et al. CARMN Regulates Atherosclerosis via SMC Modulation Hanna, et al. Cardiac Neuronal Control of the Sinoatrial Node Cuevas, et al. Introduction to the Aortic Valve Disease Series Compendium on Heart Failure Cindy St. Hilaire: Hi and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today, I will be highlighting topics presented in our April 30th and May 14th issues of Circ Res. I'll also speak with Dr David Durgan and his graduate student, Huanan Shi, from Baylor School of Medicine about their study Restructuring The Gut Microbiota by Intermittent Fasting Lowers Blood Pressure. Cindy St. Hilaire: The first article I want to share comes from the April 30th issue of Circ Res and is titled CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice. The first author is Francesca Vacante and the corresponding author is Andrew Baker, and they're from the University of Edinburgh. The increased proliferation and migration of local vascular smooth muscle cells is part of the complex pathology of atherosclerotic plaques. These proatherogenic changes to smooth muscle cells are regulated in part via two micro RNAs, miR-143 and miR-145. And these are located together on human chromosome five. In this very same genetic locus is also a gene encoding a long non-coding RNA called cardiac mesoderm enhancer-associated non-coding RNA or CARMN. Cindy St. Hilaire: This team found that levels of CARMN and miR-143/145 RNAs in mouse and human atherosclerotic plaque decreased as the condition worsened. Mechanistic experiments showed that this decrease drove smooth muscle cell pathology. Knock down of all three RNAs promoted increased proliferation and migration of human artery smooth muscle cells with the loss of CARMN specifically and independently, triggering increased proliferation. The team went on to show that in mice, loss of CARMN accelerated the progression of induced atherosclerosis. Together, the work highlights the interplay between these noncoding RNAs and atherosclerotic disease progression. Cindy St. Hilaire: The second article I want to share is titled Innervation and Neuronal Control of the Mammalian Sinoatrial Node, a Comprehensive Atlas. The first author is Peter Hanna and the corresponding author is Kalyanam Shivkumar from UCLA. The nervous system regulates cardiac physiology and influences pathophysiological adaptations to disease. Mapping the intrinsic neurocircuitry of the heart is necessary if we are to fully understand how neural circuits function in health and in diseases such as arrhythmia. Neural circuits from outside the heart meet up with those within the heart at ganglionated plexuses on the heart surface. One such plexus is the right atrial ganglionated plexus, RGAP. And RAGP is thought to regulate the signal inputs from the vagus nerve into the sinoatrial node or the SAN, which is the heart's pacemaker. Cindy St. Hilaire: To develop a detailed description of the connections between the RAGP and the SAN, this group used the pig's heart as it is a close anatomical match to that in a human's. Performing a combination of tissue clearing, immunohistochemistry and 3D fluorescent microscopy, this group showed that approximately 99% of the neurons in RAGP and most of those innervating the SAN, are cholinergic neurons. In spite of this, single cell transcriptomic analysis revealed a great deal of phenotypic diversity among these RAGP neurons. Through electrophysiological and neural ablation studies, the team revealed the extent of RAGPs modulation of the sinoatrial node functions, which characterizes the RAGP as an integrative neural structure and not just a relay station within the intrinsic cardiac nervous system. This work now creates a very detailed reference atlas of the RAGP sinoatrial node conductivity and a framework for mapping other aspects of the intrinsic cardiac nervous system. Cindy St. Hilaire: The April 30th issue of Circ Res also has a short review series on calcific aortic valve disease. Dr Rolando Cuevas and I write an introduction to this series. Dr Joy Lincoln covers genetic and developmental contributors to aortic stenosis, Dr Jonathan Butcher covers inflammatory and biomechanical drivers of endothelial interstitial interactions in calcific aortic valve disease. Dr Tom Gleason covers current therapeutic options in aortic stenosis and Dr Elena Aikawa covers multi-ohmic approaches to define calcific aortic valve disease pathogenesis. Cindy St. Hilaire: The May 14th issue of Circulation Research is the heart failure compendium. This features 10 articles written by the leading experts, who present an update on the state of the field of heart failure research and current therapeutic options. Dr Douglas Mann is the guest editor of this compendium, and in his introduction, he emphasized his vision that the authors of this series, "Focusing on linking disease pathophysiology with the mechanisms action of current therapies, with the hope that past successes would serve as a prologue for the development of future therapies." Together, these Reviews present the recent therapeutic advances in heart failure and is truly representative of the successful transition of bench top research to the bedside of patients. Cindy St. Hilaire: In the first article in the compendium, Dr Veronique Rogers provides an update on heart failure epidemiology, including a focus on the role of healthcare disparities. Dr Michael Felker, and Dr Mann follow with an overview of the pathophysiology of heart failure with reduced ejection fraction and highlight how several successful heart failure trials fit or do not fit into the current conceptual translational models of heart failure. Dr Walter Paulus and Michael Zile discuss heart failure with preserved ejection fraction, with a focus on the role of systemic inflammation and myocardial stiffness, and relate this pathophysiology to distinct clinical phenotypes and tailored medical therapies. Cindy St. Hilaire: Drs Joyce Njoroge and John Teerlink discuss what is currently known regarding pathophysiology of acute decompensated heart failure, and present a handful of new therapy developments. Drs Gary Lopaschuk, Qutuba Karwi, Rong Tian, Adam Wende, and Dale Abel discuss cardiac energy metabolism and heart failure and review several promising approaches to beneficially altering metabolism in the failing heart. Highly relevant to the long-term cardiovascular phenotype seen in patients who have had COVID-19, Drs Ray Hershberger, Jason Cowan, Elizabeth Jordan, and Daniel Kinnamon reviewed the genetic basis for dilated cardiomyopathy and discuss what is known regarding the interaction of genetic risk and environmental factors. Cindy St. Hilaire: Drs Jan Griffin, Hannah Rosenblum and Matthew Maurer discussed cardiac amyloidosis due to light chain or transthyretin amyloidosis and cover current effective therapeutic strategies and active clinical trials. Drs Virginia Hahn, Kathleen Zhang, Lova Sun, Vivek Narayan, Daniel Lenihan, and Bonnie Ky covered the development of heart failure due to targeted cancer therapies and discuss the rationale and evidence supporting different cardiotherapeutic approaches. Cindy St. Hilaire: The Compendium concludes with an article by Drs Daniel Burkhoff, Veli Topkara, Gabriel Sayer, and Nir Uriel that discusses the current state of left ventricular assist devices or LVADs and the structural, cellular and molecular aspects of LVAD associated reverse left ventricle remodeling. This comprehensive Compendium on Heart Failure is found in the May 14th issue of Circulation Research. Cindy St. Hilaire: So today, Dr David Durgan and Huanan Shi from Baylor College of Medicine are here with me to discuss their study, Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure, which is in our April 30th issue of Circulation Research. So thank you both very much for joining me today. David Durgan Pleasure to be here. Cindy St. Hilaire: So this study is bringing together two hot fields, the gut microbiome and intermittent fasting, and it's in the context of high blood pressure, which obviously is a national and global crisis. But before we jump into the details of the paper, could you just define what is meant by gut microbiome and intermittent fasting for the purposes of the discussion? David Durgan: Sure. So when were you referred to the gut microbiome or the gut microbiome, what we're really referring to there are all the microbes that are residing in the gut. So this can be the complex composition of bacteria, viruses, fungi. However, for the purposes of our studies, we really focus in just on the bacteria. Cindy St. Hilaire: So how did you even come to this question? What was the premise that existed such that you wanted to ask this question? Microbiome, intermittent fasting, and hypertension? Dr David Durgan: It really started in terms of understanding the connection between the biome and hypertension. And this actually all started in a separate model of hypertension that we developed here in our lab. And that was a model of obstructive sleep apnea. When we were first developing this and characterizing this, one of the strange observations that we found is that these animals did not have any change in blood pressure, which was contrary to what we see in patients and even what they see in the intermittent hypoxia models. David Durgan: So when we started thinking about OSA and the patient, we started thinking about all these other co-morbidities, one of them being obesity and poor diet. So at this point we started adding in other morbidities, such as a high-fat diet. And we found that very quickly within one week, actually, when we had the combination of both apnea and high fat diet, that this was then leading to the increase in blood pressure. And really lucky, right place at the right time was that we were thinking about what the high-fat diet was doing. And there was a seminar here on campus about the gut microbiota, which we really had done nothing with up to that point. And after attending that, it quickly became obvious that our high-fat diet was going to be shifting the biota. So this is what really led us to making this connection between changes to the microbiome and blood pressure. Cindy St. Hilaire: So can you tell me little bit about the design of your study, about the animal systems you use and the diet and the regime that you put them on? David Durgan: Sure. So we went into this with two overall questions. So we had already shown previously in this model that the biota was disrupted and that was contributing at least to the hypertensive phenotype. So we came into this and wanted to address the questions of, one, what are the mechanisms through which the microbiota is influencing host blood pressure? And then two, is there some type of intervention that we could do to shift the makeup of the microbiota and see how that affected the hypertensive phenotype? David Durgan: So to address those two components, we took the spontaneously hypertensive stroke prone rat, and it's normotensive parent strain, the WKY, and we put them either on a normal ad libitum food access or every other day fasting, which is just as it sounds, it was a full 24 hours of ad-lib access followed by 24 hours of no food access at all. David Durgan: And this went on for 10 weeks with constant assessment of food intake, body weight, blood pressure. And then at the end, we isolated fecal content in order to look at the effects on the biome. And that was done with whole genome shotgun sequencing, but we also did a on-targeted metabolomics approach of both the fecal content and the plasma in order to get a real understanding of what are some of the microbial metabolites that could be influencing hosts. Cindy St. Hilaire: Such an interesting question. And it's such a complex idea, but I thought you did a really great job winnowing it down as your paper progressed. And you did find that the every other day feeding reduced blood pressure in the hypertensive stroke prone rats, and interestingly or maybe not interestingly to you, but I thought it was interesting, is that those every other day fed animals, they certainly ate more on the days when they were allowed to eat. And obviously on the days they weren't, they were eating less. And so their overall food intake was less. And ultimately at the end of your trial period, their weight was less. So are these effects that you see on blood pressure more directly related to the weight loss or to the actual microbiome? And how did you confirm that? Huanan Shi: So that's actually a very good question. A lot of the intermittent fasting related studies definitely can separate the effects of the fasting itself and the effects of the weight loss as intermittent fasting has been used very frequently as a method for obesity and reduce body weight. So to confirm that the effects is through intermittent fasting, to restructuring the microbiome, a sort of indirect route from the weight loss, so we collected fecal sample of these animals that have been fed either on the intermittent fasting protocol or ad libitum with food access every day. We then transferred the fecal content through our garage into germ-free rats which they do not have an established gut microbiota. Huanan Shi: So these germ-free animals who'll receive the hypertensive HSR mode] biota with just regular feeding pattern also developed high blood pressure compared to those who received the normotensive microbiota. So interestingly is that the animals that received the microbiota from the hypertensive animal that also was fed on the fasting protocol did not develop a high blood pressure. So this study actually tells us that maybe the weight loss have some effects, but through the microbiota transplant study, we show that majority or the conjoined factors mostly from the changes in microbiota instead of the weight loss. Cindy St. Hilaire: Yeah. It also makes me wonder how much of the microbiota changes actually influence the weight loss as well. I wonder that's probably a whole another black box to open. You did find that in the feeding regime differences, there was a difference in the actual communities of bacteria. Can you talk maybe about the implications of what that means, and also does that mean this is perhaps something that we could recapitulate with a pill, like with a probiotic pill of some sort? David Durgan: Yeah. So some of the overall changes that we see, we do see pretty drastic changes in the beta diversity of the community. This being things like richness, evenness, the number of species that are actually present and really pretty interestingly, the way that we saw those shift was that the SHR that were undergoing the fasting protocol, their community structure overall seemed to shift more closely to resemble that of the normotensive WKY. So there were some pretty large shifts. And then when we get down to some of the genera and species levels, we again see that many of these are being normalized to look much more like the communities of the WKY. David Durgan: In terms of taking a pill or something along that source, somewhat surprisingly, actually we found that in the hypertensive animal, a number of species that are commonly thought of as probiotics. So for instance, bifidobacteria and lactobacillus, which are two of the only FDA approved genera for probiotics, they were actually higher in our SHR control fed animals. So I think there's still a lot of work to be done to understand exactly the contribution of individual species. Maybe what's more important is understanding the functional output from the community as a whole. So what are some of the metabolites that are actually influencing the host? Cindy St. Hilaire: So it may not be the bacteria itself, but perhaps the products that create. David Durgan: Right. And the thing that's frustrating, but also exciting about this is that there's so much functional redundancy between different species, meaning that while you could have loss of one species, it may look very significant on paper, but it could be that other species in the community are making up for that. So they're able to make the same metabolites and thereby overcome that deficiency. Cindy St. Hilaire: Got it. Got it. So it may not really be that big of a shift per se. David Durgan: Yeah. We can't always go off of just what is the species change and that's why we really moved and thought it was important to move on to looking at the metabolites themselves. Cindy St. Hilaire: So you did see that these hypertensive rats had more an inflammatory profile in certain sections of the gut. And I was trying to think about this in terms of humans. And I don't know if it's known, but do patients with IBS or with chronic diseases like Crohn's disease or some other gut inflammation phenotype, do they actually have more hypertension or develop it earlier? I guess I'm thinking of this in terms of cause and consequence, the hypertension influence the gut microbiome, or do you think the microbiome perhaps is driving the hypertension? David Durgan: That's a great question. I've tried to look and see if there's any real conclusive evidence for inflammatory GI disorders and a concrete connection to elevated blood pressure. Personally, I've not found convincing evidence of that at this point in time. Cindy St. Hilaire: So in terms of the metabolites, I thought it was really interesting that you found, I think it was a reduction in bile acids, and specifically you then explored further choline, that that was at play in this hypertensive state. So can you discuss what it is you exactly found and then what this might mean in terms of hypertension pathogenesis? David Durgan: Yeah. So from our un-targeted metabolomics data, we performed random forest analysis to try and understand some of the broad pathways that were altered. First of all, just differences between our hypertensive and normotensive control animals, but then also how the fasting affected those metabolites. And there were a number of pathways of interests, which need to be followed up on, but the one that really stood out to us was primary and secondary bile acid metabolism. Now, we followed up on this by doing a targeted approach to look at a specific panel of primary and secondary bile acids. And we were really very surprised at just how different they were. We measured, I believe, 17 different bile acids. And we found that in the plasma, that 12 of these were significantly lower in a hypertensive model. So this was really exciting. David Durgan: And the more we looked into this, it really all make sense in terms of that if you look at where bile acid receptors are located, they're present in the endothelium and smooth muscle, in brain, on inflammatory cells. So we've really, I think, just started to see the tip of the iceberg in terms of their effects systemically. In a final figure of our paper, we look at their effects on vascular function and show that by giving a TGR5 agonist, which is one of the bile acid receptors that we could improve vascular function in this hypertensive model. I mean, bile acids classically have really been looked at in regards of strictly in the liver and the GI and in the inner hepatic circulation. But just the fact that we see these receptors so widespread systemically really tells us that even though the concentrations may seem low and plasma relative to in the GI tract, that they're very likely having pretty profound effects on overall physiology. Cindy St. Hilaire: . So do either of you follow an intermittent fasting diet and also, I guess more specifically about IF is these rats, the study, you did every other day feeding. So for humans, obviously I think right now it's Ramadan so a lot of people are almost doing that now. But for humans, that seems like a stretch. I don't think I would really want to do that regularly. So do you think any of these findings could also be similar for different forms of intermittent fasting? I know like that 8/16 hour breakdown is the popular one. What do you think about that? David Durgan: I personally have not tried it. There have been some grad students that have come through the lab and actually one of the investigators on this paper who worked with me to develop this idea, he was very into ... I think he did the 16/8 that you're referring to. Cindy St. Hilaire: Okay. Yeah. David Durgan: But yeah, I mean, that's really kind of been a hindrance almost in the field is that you go to understand clinical studies on intermittent fasting, and there's just so many different protocols out there. Whether it be looking at outcomes or blood pressure or whatever effect on physiology during Ramadan, during a 16/8, during every other day. And it's really muddied the waters in terms of understanding the overall effects, but looking through all of that, it does appear that even in the small clinical studies that are out there, that there does appear to be some benefit. There is a every other day fasting. So very similar to exactly the same as our protocol in a small randomized controlled trial. And it should be said that these were healthy individuals, but even after just four weeks of EODF or every other day fasting, there was about a 5 mm decrease in blood pressure in individuals. David Durgan: The followup papers from that group really should be very interesting. So these individuals have now gone back on a normal feeding regimen, but they plan, I believe, to look at intervals out to two years to see how long lasting these effects are. Cindy St. Hilaire: Interesting. The other thing with humans, I mean, obviously your rats, they're eating one meal, the same meal, essentially. Humans eat a variety of things at every meal at every different day. Sometimes they have a bag of candy because it's Easter or whatever, so that doesn't help either. So what was the most challenging part of the study? David Durgan: This required a lot of legwork by Fred in terms of some of the multi-omics analysis. Huanan Shi: For me, two part. One part is definitely analyze these data using the machine learning protocol. A lot of things I had to learn from scratch. And eventually, it's a lot of time-consuming troubleshooting, but I'm glad everything went through pretty well. I guess something else will be since these rats are eating and fasting at the same time every day and so you have to come in every day at the same time to change cages, like food. So, yeah. Cindy St. Hilaire: Collect poop. Well, it was a beautiful, really well done study. I thought it was super interesting. We talk about what's the next podcast going to be at all of our editorial meetings and this paper, everyone thought it was a great topic. It's just really timely with the intermittent fasting. It was really wonderful. What do you think is next? What are you going to do next on this? David Durgan: So I think there's a lot to do next. I think that one of the most interesting ideas really I alluded to earlier, and that is the widespread distribution of these bile acid receptors. So while we've taken an initial look at vascular function, I think that there's a lot to do elsewhere. We're really interested in how this could be affecting the neurological component of hypertension. Many of these bile acids signaling pathways have been shown to be anti-inflammatory. So do we see changes in neuro inflammation, in sympathetic output? One we're capable of elevating bile acids, which are capable of passing the blood-brain barrier should be noted. So that's definitely one. And then also just beginning to look at how translational this might be. So do we see changes in bile acids in hypertensive patients as well? Cindy St. Hilaire: You're talking about the receptors and that last figure paper figure seven where you use, I forget if it was an agonist or antagonist, but you modulated that receptor activity. Do resistance arteries, which have a bigger role in hypertension, do they have higher or different levels of expression than other vascular beds in the body? Or do we not know that yet? David Durgan: I can think of studies that have shown similar results in terms of bile acids on vascular function, both in aorta and in mesenteric arteries. But whether the distribution is different on these receptors, I'm not really sure that's known. Cindy St. Hilaire: Well, there's lots of super interesting questions. I mean, I came up with bunches more that I wanted to know based on the study. So I'm sure that will pan out for you, hopefully with lots more great papers like this one and funding and congrats on an excellent graduate student paper. It was a real great story. And thank you both for joining me today. David Durgan: Thank you very much. Cindy St. Hilaire: That's it for the highlights from the April 30th and May 14th issues of Circulation Research. Thank you for listening. Please check out the Circ Res Facebook page and follow us on Twitter and on Instagram with the handle @circres and hashtag discovercircres. Thank you to our guests, Dr David Durgan and Huanan Shi. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire and this is Discover CircRes, your on-the-go source for the most up-to-date and exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2021. The opinions expressed by the speakers in this podcast are their own and not necessarily those of the editors or the American Heart Association. For more information, visit ahajournals.org.
I have always had a love for street art, and it started in high school. This boy who grew up in the country loved the culture behind the form of expression in the city. Or at least the culture as I understood it.This week's guest is someone I discovered back in those high school days when I was turning garage sale stickers into pictures and phrases and slapping them in the boy's locker room at school. Justin Pape was known as We Kill You (WKY) when I discovered him. His street art was incredibly simple, featuring a black sharp toothed mouth and round eyes on a white background. It was the minimal look that attracted me at the time. And upon rediscovering him, I found that he'd taken his art to professional heights.We talk about his early days getting into art, from making skateboard decks, to wheat pasting his WKY art throughout Toronto, Ontario. His time spent designing art for the hotel industry, marketing pieces for Indigo Books, sculptures for galleries, and record sleeves for musicians. There's much more and a lot to walk away with this week, so tune in! Follow Nonethelesser on Instagram, leave a review on Apple Podcasts.Follow Justin Pape on Instagram, and check out his website.The music in this episode was produced by Cro_ft.
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
The Dark Fantasy radio show first aired in November 1941 from Oklahoma City’s WKY radio station but was later syndicated across the US via the NBC Network. All the stories were written by Scott Bishop. The show ran for a total of 31 episodes and the final episode was aired on June 19th 1942. The show had a late-night radio slot so some of the tales transmitted were a little darker than those of competing radio shows, broadcast earlier in the evenings. Sherlock Holmes Radio Station Live 24/7 Click Here to Listen Check Out Our Range Of Radio Shows
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.17.158279v1?rss=1 Authors: Barnett, S. J., Dong, R., Briggs, L., Moushey, A., Li, A. Abstract: It has been established that an overactive orexin (OX) system is associated with neurogenic hypertension in spontaneously hypertensive rats (SHRs). However, the chronology and mechanism of such association between orexin system and hypertension is unclear. We hypothesized that an aberrant surge of OX neurons in SHRs precedes the aberrant increase of arterial blood pressure (ABP) during postnatal development, which was primarily contributed by the exaggerated postnatal OX neurogenesis. We found that (1) SHRs experienced a greater surge in the number of orexin neurons than normotensive Wistar41 Kyoto (WKY) rats before P16, which led to significantly more OX neurons than age42 matched controls by P15-16 (3680+/-219 vs 2407+/-182, respectively, P=0.002). (2) Exaggerated OX neurogenesis, marked by bromodeoxyuridine (BrdU), was the primary contributor to excessive OX neurons in SHRs during development. (3) In contrast, SHRs and normotensive control rats have similar mean arterial blood pressure (ABP) at P15, and a significantly higher ABP in SHR than WKY emerges at P20 (74.8 +/- 2.5 vs 66.9 +/- 4.4 mmHg in wakefulness, respectively, P
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.24.057570v1?rss=1 Authors: Lillywhite, A., Woodhams, S. G., Watson, D. J. G., Li, L., Burston, J. J., Gowler, P. R. W., Canals, M., Walsh, D. A., Hathway, G. J., Chapman, V. Abstract: Chronic pain states such as osteoarthritis (OA) are often associated with negative affect, including anxiety and depression. This is, in turn, associated with greater opioid analgesic use, potentially contributing to current and future opioid crises. We utilise an animal model to investigate the neurobiological mechanisms underlying increased opioid use associated with high anxiety and chronic pain. Combining a genetic model of negative affect, the Wistar Kyoto (WKY) rat, and intra-articular injection of monosodium iodoacetate (MIA; 1mg), our model of high anxiety and augmented OA-like pain behaviour mirrors the clinical problem. Effects of morphine (0.5-6mg.kg-1) on pain behaviour and spinal nociceptive neuronal activity were determined in WKY rats, and normo-anxiety Wistar rats, 3 weeks after MIA injection. WKY rats developed augmented OA-like pain, and had blunted inhibitory responses to morphine, when compared to Wistar rats. Potential alterations in endogenous opioid function were probed via systemic blockade of opioid receptors with naloxone (0.1-1mg.kg-1), quantification of circulating levels of {beta}-endorphin, and determination of spinal expression of the mu-opioid receptor (MOR). These studies revealed increased opioidergic tone, and increased spinal desensitization of MORs via the master phosphorylation site at serine residue 375, in this model. We demonstrate attenuated MOR function in the absence of previous exogenous opioid ligand exposure in our model of high anxiety and OA-like pain, which may account for reduced analgesic effect of morphine and provide a potential explanation for increased opioid analgesic intake in high anxiety chronic pain patients. Copy rights belong to original authors. Visit the link for more info
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ComicWeb.com sells comics, old time radio programs and more
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Dark Fantasy was supernatural thriller anthology series originating from station WKY in Oklahoma City and heard Friday nights on NBC stations between Nov 1941 and Jun 1942. Its writer was Scott Bishop, also known for his work on The Mysterious Traveler.
Dark Fantasy: “The Man Who Came Back (8/21/48). *** Nightfall: “Love and the Lonely One”.(7/4/80) .*** LibriVox: Evelyn E. Smith’s: “The Blue Tower”(1958). *** Mystery in the Air: “The Marvelous Barastro” (8/7/47). *** Strange Doctor Weird: “The Man Who Lived Twice” (1/30/45). *** Right Click here to download Originating from WKY in Oklahoma City Dark […]
Dark Fantasy was an series dedicated to dealings with the unknown. Originating from radio station WKY, Oklahoma City, it was written by Scott Bishop (of Mysterious Traveler and The Sealed Book fame) and was heard Fridays over stations. Keith Paynton served as announcer. The shows covered horror, science fiction and murder mysteries. Although a short series, the shows are excellent with some stories way ahead of their time. TODAY'S SHOW: "The Man Who Came Back" (11-14-41) and "Death Is A Savage Diety" (01-30-42) November 14, 1941. NBC network, WKY, Oklahoma City origination. "The Man Who Came Back". Sustaining. A killing after an argument about a man's wife leads to a promise to return from the grave for vengeance. Scott Bishop (writer), Muir Height, Eugene Frances, Ben Morris, Eleanor Naylor Corin (?), Fred Wayne, Murillo Scofield (?). 24:41 January 30, 1942. Program #11. NBC network"Death Is A Savage Diety". Sustaining. A tale of witchcraft and black magic, based on the novel by Scott Bishop. The system cue has been deleted. Scott Bishop (writer), Tom Paxton (announcer). 24:25.
Dark Fantasy was a series dedicated to dealings with the unknown. Originating from radio station WKY, Oklahoma City, it was written by Scott Bishop (of Mysterious Traveler and The Sealed Book fame) and was heard Fridays over stations. Tom Paxton served as announcer. The shows covered horror, science fiction and murder mysteries. Although a short series, the shows are excellent with some stories way ahead of their time. The following is a news promo promoting the show: Every since Lights Out went out several years ago, fans of the fiendish have been clamoring for more good old goose-pimple horror drama on the air. Now they have it. One of the programs that currently freezes the airwaves with its chilling stories is Dark Fantasy comparatively new to the networks. In the late hours of Friday nights these shivery, shocking stories go out over NBC - right straight from Oklahoma City, which you might not have thought of as headquarters for haunts. Station WKY is the home of the Dark Fantasy plays, and the writer is Scott Bishop, who lives in the midst of mystery and the supernatural, represented by the innurnerable volumes of thriller fiction, fantasy lore and all kinds of horror literature that fill his home andhis office. Bishop has long contributed to network broadcasting and to magazines. He says, "Give the listener enough material to let his imagination go to work, and he'll supply his own goose-pimples." Dark Fantasy has been furnishing plenty of such material since last November. And judging from enthusiastic comment, the horror fans are responding with goose-pimples galore! Tune in every Friday on Station WKY Oklahoma City. SHOW NOTES From the Old Time Radio Researcher's Group. THIS EPISODE: January 9, 1942. Program #8. NBC network, WKY, Oklahoma City origination. "The Curse Of The Neanderthal". Sustaining. Not auditioned. "The story of a grave forty thousand years old, and the awesome secret that it contained." Scott Bishop (writer), Tom Paxton (announcer), Ben Morris, Eleanor Naylor Corin, Murillo Scofield, Fred Wayne, Daryl McAllister. 26:55.
Dark Fantasy was an series dedicated to dealings with the unknown. Originating from radio station WKY, Oklahoma City, it was written by Scott Bishop (of Mysterious Traveler and The Sealed Book fame) and was heard Fridays over stations. Keith Paynton served as announcer. The shows covered horror, science fiction and murder mysteries. Although a short series, the shows are excellent with some stories way ahead of their time.
Dark Fantasy was an series dedicated to dealings with the unknown. Originating from radio station WKY, Oklahoma City, it was written by Scott Bishop (of Mysterious Traveler and The Sealed Book fame) and was heard Fridays over stations. Keith Paynton served as announcer. The shows covered horror, science fiction and murder mysteries. Although a short series, the shows are excellent with some stories way ahead of their time. Go To GoDaddy, use the promo code blu19 and save 10%
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