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4 episodes with blood brain barrier
4 episodes with blood brain barrier
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2 episodes with blood brain barrier
2 episodes with blood brain barrier
2 episodes with blood brain barrier
3 episodes with blood brain barrier
8 episodes with blood brain barrier
3 episodes with blood brain barrier
Managing ADHD naturally can feel overwhelming, but what if there were powerful plant-based remedies that could help? In this episode of The Soaring Child Podcast, host Dana Kay explores the best herbs for ADHD, breaking down the science behind how they support focus, reduce stress, and regulate emotions. She covers research-backed benefits of herbs like Rhodiola Rosea, OPCs, ginkgo, and ginseng—offering practical strategies for incorporating them into your child's routine. Dana Kay, a leading ADHD health practitioner, has helped thousands of families find natural, effective solutions for ADHD symptoms. In this episode, she provides a clear, no-fluff guide to using herbs safely and effectively. Whether you're new to natural remedies or looking to refine your child's supplement plan, this episode is packed with actionable insights you won't want to miss! Make sure and grab your Herbs for ADHD Cheat Sheet at the link provided! Links Mentioned in the Show: Functional Lab Testing Video - https://info.adhdthriveinstitute.com/lab-testing-for-adhd1 My Favorite Place to Buy Supplements - http://adhdthriveinstitute.com/supplements My Favorite Herbs that are Mentioned in this Episode: Rhodiola Rosea - https://shop.adhdthriveinstitute.com/rhodiola-rosea.html OPC - https://shop.adhdthriveinstitute.com/curcumasorb-mind-60-capsules.html Ginkgo - https://amzn.to/4ij9EK1 Ginseng - https://amzn.to/4ihGDye Herbs for ADHD Cheat Sheet - https://info.adhdthriveinstitute.com/supplement-for-adhd-herbs Links to Previous Episodes in this Supplements for ADHD Series: Magnesium - https://adhdthriveinstitute.com/podcast/soaring-child-episode-93/ Saffron - https://adhdthriveinstitute.com/podcast/soaring-child-episode-136/ GABA - https://adhdthriveinstitute.com/podcast/soaring-child-episode-137/ L-Theanine - https://adhdthriveinstitute.com/podcast/soaring-child-episode-142/ Bio Essentials - https://adhdthriveinstitute.com/podcast/soaring-child-episode-144/ Omegas - https://adhdthriveinstitute.com/podcast/soaring-child-episode-146/ Iron - https://adhdthriveinstitute.com/podcast/soaring-child-episode-148/ Vitamin D - https://adhdthriveinstitute.com/podcast/soaring-child-episode-150/ Zinc - https://adhdthriveinstitute.com/podcast/soaring-child-episode-152/ Zembrin - https://adhdthriveinstitute.com/podcast/soaring-child-episode-154/ Key Takeaways: [3:04] Overview of Rhodiola Rosea and Its Benefits [3:49] Scientific Studies on Rhodiola for ADHD [4:23] How to Choose and Use Rhodiola Safely [8:45] Introduction to OPCs and Their Brain-Boosting Effects [9:14] The Role of OPCs in Strengthening the Blood-Brain Barrier [10:15] How OPCs Improve Cognitive Function and Focus [13:10] Ginkgo & Ginseng: Natural Stimulant Alternatives [14:15] Key Considerations Before Using Herbs for ADHD [14:52] Final Thoughts and Actionable Next Steps Memorable Moments: "Herbs are powerful plant-based remedies that could sharpen focus, reduce stress, and support emotional regulation—and most people completely overlook them." "Rhodiola is like a built-in stress shield for the brain. It helps calm that chaos, sharpen focus, and smooth out emotional roller coasters." "In just one week, people taking Rhodiola felt less stressed, more focused, and mentally sharper." "Rhodiola was compared to the antidepressant sertraline, also known as Zoloft. While sertraline had stronger effects, Rhodiola had fewer side effects and was better tolerated." "Research shows Rhodiola may enhance memory and learning by helping neurons in the brain communicate better." "OPCs are antioxidants found in blueberries, grapes, and dark chocolate, and they help protect the brain while strengthening the blood-brain barrier." "One study found that drinking blueberry juice, which is rich in OPC flavanols, for 12 weeks improved working memory, blood flow to the brain, and cognitive performance in adults." "Ginkgo and ginseng act like stimulants without the side effects, and studies show they may help improve attention and dopamine levels in kids with ADHD." "Herbs are powerful, even though they're natural. They can interact with medications, so always consult a professional." "There is no one-size-fits-all approach. Functional lab testing can help determine which nutrients and herbs your child actually needs." Dana Kay Resources:
For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr. Richard Frye https://drfryemdphd.comRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurological Health Foundation https://neurologicalhealth.orgHealthy Child Guide https://neurologicalhealth.org/the-guide-5/Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.co/?ref=autismuse "autism" for a 10% discount,0:00 Dr. Richard Frye0:58 Daylight Computer Company5:17 Chroma Light Devices8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)17:34 Cerebral Folate deficiency; BH4, Placenta & Womb23:35 Folate deficiency & Autism26:21 Clinical Studies & Data29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration42:53 Folate Autoantibodies & Maternal Health & Markers45:30 Studies & Behavioral outcomes; inflammation & thyroid findings46:58 Neural development; Language connections, white matter tracts & distal connections48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida51:08 Preparing for pregnancy53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness59:32 Guidance & SupportX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com
Dr. Thomas Chen, Founder, CEO, and CSO of NeOnc Technologies, is working on the challenge of delivering drugs across the blood-brain barrier by using an intranasal delivery approach to target brain cancers. This delivery platform leverages the cranial nerve to transport the drugs directly to the brain, bypassing the blood-brain barrier. Genomic analysis of the long-surviving patients in the phase one trial revealed a common genetic mutation, informing the trial design for the next phase. Thomas explains, "So our platform is what we call intranasal delivery. And with the intranasal delivery, we're not trying to cross the blood-brain barrier. We're trying to cross over it. And how we're doing that is doing the delivery of the drug via what we call the C nerves. Now the cranial nerves are, we have 12 cranial nerves in our brain. These cranial nerves have various functions, but the cranial nerves involved with the nasal brain delivery are the first and the fifth cranial nerves. The first cranial nerve is what we call the olfactory nerve. That's the nerve that's responsible for smell. The fifth cranial nerve is called the trigeminal nerve, which involves facial sensation and allows us to chew." "So what happens is that when we want to deliver the drug to the brain cancer, we have the patient inhale it. When the patient inhales, it goes through the nose, and through the olfactory nerve, it goes to the brain. Usually, that molecule then absorbs in the spinal brain and then circulates to the target, in this case, brain cancer. Now you know how powerful that cranial nerve is from the standpoint of what it does when you smell something, that scent, that odor gets transported from the olfactory nerve to our brain. And that's basically what we're doing. We're taking something external to the brain, allowing the cranial nerve to absorb and transport it to the brain." #NeOnc #BloodBrainBarrier #BBB #BrainCancer #DrugDelivery neonc.com Download the transcript here
Dr. Thomas Chen, Founder, CEO, and CSO of NeOnc Technologies, is working on the challenge of delivering drugs across the blood-brain barrier by using an intranasal delivery approach to target brain cancers. This delivery platform leverages the cranial nerve to transport the drugs directly to the brain, bypassing the blood-brain barrier. Genomic analysis of the long-surviving patients in the phase one trial revealed a common genetic mutation, informing the trial design for the next phase. Thomas explains, "So our platform is what we call intranasal delivery. And with the intranasal delivery, we're not trying to cross the blood-brain barrier. We're trying to cross over it. And how we're doing that is doing the delivery of the drug via what we call the C nerves. Now the cranial nerves are, we have 12 cranial nerves in our brain. These cranial nerves have various functions, but the cranial nerves involved with the nasal brain delivery are the first and the fifth cranial nerves. The first cranial nerve is what we call the olfactory nerve. That's the nerve that's responsible for smell. The fifth cranial nerve is called the trigeminal nerve, which involves facial sensation and allows us to chew." "So what happens is that when we want to deliver the drug to the brain cancer, we have the patient inhale it. When the patient inhales, it goes through the nose, and through the olfactory nerve, it goes to the brain. Usually, that molecule then absorbs in the spinal brain and then circulates to the target, in this case, brain cancer. Now you know how powerful that cranial nerve is from the standpoint of what it does when you smell something, that scent, that odor gets transported from the olfactory nerve to our brain. And that's basically what we're doing. We're taking something external to the brain, allowing the cranial nerve to absorb and transport it to the brain." #NeOnc #BloodBrainBarrier #BBB #BrainCancer #DrugDelivery neonc.com Listen to the podcast here
In this insightful episode of the Experience Miracles Podcast, Dr. Tony Ebel interviews Dr. Meg Mill, a functional medicine expert with a background in pharmacy who specializes in the gut-brain connection. They explore how the nervous system plays a crucial foundational role in gut health, anxiety, and overall wellness. Dr. Mill shares her personal health journey that led her to functional medicine and introduces her 3R Protocol (Regulate, Repair, Rewire) for addressing health challenges. The conversation highlights why traditional treatments often fail to address the interconnected nature of gut issues and mental health concerns, and offers practical insights for parents seeking drug-free solutions for their children's chronic health challenges.[00:00:00] Introduction & Dr. Meg's Personal JourneyDr. Meg's transition from pharmacy to functional medicinePersonal struggles with gut issues, anxiety, and sleep problems that conventional medicine couldn't solve[00:09:00] The Nervous System-First ApproachWhy prioritizing nervous system regulation before nutrition creates better outcomesThe typical patient journey: conventional medicine → nutritional approaches → nervous system regulationThe importance of breaking this cycle by addressing the foundation first[00:14:00] Sympathetic Dominance & Digestive HealthHow the autonomic nervous system affects digestionThe physiological cascade when we're stuck in "fight or flight"Why stress creates digestive issues even with a perfect diet[00:25:00] The Anxiety-Digestion LoopThe vagus nerve's role in gut-brain communicationHow gut dysbiosis leads to immune responses and brain inflammationClarification about serotonin in the gut (primarily for motility, not mood)[00:38:00] The Blood-Brain Barrier & Individualized CareConnection between gut permeability and blood-brain barrier integrityThe importance of personalized, whole-body approaches to healing[00:46:00] The 3R Protocol ExplainedRegulate: Bringing balance to physiological systemsRepair: Healing damaged barriers and tissuesRewire: Neuroplasticity, vagal nerve toning, and nervous system retraining[00:54:00] Resources & Closing ThoughtsDr. Meg's podcast: "A Little Bit Healthier"The value of addressing nervous system regulation as the foundation for all healingGet connected with Dr. Meg Millwebsite: megmill.com instagram: @megmill-- Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!
Send us a textDr. Thomas Chen, MD, Ph.D. is Founder, CEO & CSO, and Board Director, of NeOnc Technologies ( https://neonc.com/ ), a developer of a proprietary, patented platform technology that can potentially transport pharma-based therapeutics directly to the brain without the normal boundary restrictions imposed by the body's Blood-Brain Barrier (BBB), providing patients with potentially more effective treatments.NeOnc is developing a portfolio of treatments for brain cancer and other central nervous system (CNS) disorders. Dr. Chen is a board-certified neurosurgeon and the Director of Surgical Neuro-Oncology at USC where he is also a tenured Professor of Neurosurgery and Pathology ( https://keck.usc.edu/faculty-search/thomas-c-chen/ ). Dr. Chen graduated summa cum laude from the University of Illinois at Urbana-Champaign, where he also received Bronze Tablet honors and was inducted into the Phi Beta Kappa national academic honor society. He attended the University of California, San Francisco, where he obtained his MD, and was inducted into the Alpha Omega Alpha National Medical Honor Society. He underwent neurosurgery training at USC and obtained a Ph.D. degree in pathobiology where his thesis was on the role of immunotherapy in malignant brain tumors. Dr. Chen is also a fellowship-trained spine surgeon and one of a few surgical neuro-oncologists in the country specializing in spine cancer surgery. He maintains a busy clinical practice in both surgical neuro-oncology and spine surgery and heads a research laboratory focused on glioma biology. Dr. Chen has published extensively on glioma biology and neurosurgery. He is on the editorial board for The Spine Journal and on the review board for Neurosurgery and Journal of Neurosurgery. He also serves on numerous national neurosurgery committees.#NeOnc #ThomasChen #NeurologicalSurgery #Neurosurgery #BrainTumor #Glioblastoma #Glioma #BloodBrainBarrier #NeuroOncology #Temozolomide #PerillylAlcohol #Meningioma #Neurology #CNS #SpinalCordInjury #BrainMetastases #Alzheimers #ParkinsonsDisease #Neuropathology #MedicalOncology #Chemotherapy #RadiationOncology #USC #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
“Active holistic therapy” for prostate cancer with diet and fish oil helps defer need for surgery, hormone blockade, radiation; Why 70 is the new 60; Long-term harmful effects of acid-blockers; Do memory supplements pass the blood-brain barrier? Fish oil, krill oil, olive oil for cardiovascular prevention; Paxlovid aggressively promoted but overprescribed for otherwise healthy patients.
Today's podcast comes from this blog post: Restoring the Integrity of the Blood Brain Barrier Christian Natural Health was ranked in the top 100 Christian Podcasts by Feedspot! https://blog.feedspot.com/christian_podcasts/ Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.
"After my car accident, I discovered that trauma wasn't the only cause of leaky brain - chronic stress, poor sleep, and inflammation can all compromise our brain's protective barrier. The good news? Just like leaky gut, leaky brain can be healed." - Dr. Titus Chiu In this eye-opening episode, I sit down with functional neurologist Dr. Titus Chiu to explore the fascinating concept of "leaky brain" and its profound impact on cognitive health, especially for women in midlife. Dr. Chiu's personal journey from a devastating accident to becoming a leading expert in brain health offers hope and practical solutions for anyone experiencing brain fog, memory issues, or cognitive decline. His groundbreaking research reveals how the blood-brain barrier functions like a nightclub bouncer, carefully controlling what enters our most precious organ - and what happens when that security system breaks down. Whether you're navigating perimenopause, recovering from a concussion, or simply wanting to maintain sharp cognitive function, this episode delivers actionable strategies to protect and enhance your brain health. What you'll learn: The surprising connection between leaky gut and leaky brain, and why women in perimenopause may be particularly vulnerable How to recognize the warning signs of a compromised blood-brain barrier, from brain fog to unexplained cognitive fluctuations The 5 essential pillars of brain health, including specific foods that nourish your neurons Why social connections and regular movement (especially dancing!) are crucial for preventing cognitive decline Game-changing supplements that support brain health, including the unexpected benefits of creatine! Simple breathing techniques to instantly calm the nervous system and protect your brain The critical importance of morning sunlight for resetting your brain's daily rhythm Full show notes: https://www.jjvirgin.com/brainsavequiz Learn more about Dr. Titus Chiu: https://drtituschiu.com/ Flavorchef bone broth: https://affiliates.theflavorchef.com/121.html Vital Choice wild-caught seafood: https://vitalchoice.sjv.io/daKYGy Reignite Wellness™ Plant-Based & Paleo-Inspired All-In-One Shakes: https://reignitewellness.com/collections/shakes Download my FREE Best Rest Sleep Cheat Sheet: https://jjvirgin.com/sleep Sleep Mask: https://amzn.to/3vkiMuB The Virgin Diet: https://reignitewellness.com/products/the-virgin-diet-paperback Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products Try SHEatine: https://reignitewellness.com/collections/all/products/sheatine-capsules Episode Sponsors: Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products Go to qualialife.com/VIRGINWELLNESS to try Qualia risk free for up to 100 days and code VIRGINWELLNESS for an additional 15% off Take Dr. Chiu's FREE Leaky Brain Quiz
Have you every wondered how exactly drugs are designed to access the brain? The answer usually revolves around one very important part of the central nervous system. The blood brain barrier is the layer of cells that protects the brain from pathogens while still allowing for the removal of toxins. From pain medications to ozempic, several drugs have been designed to get across this barrier in one way or another. In this episode, we are joined by an expert in the field and cover how the blood brain barrier works, how common drugs act on it, what can go wrong, and how you can leverage your own blood brain barrier. Dr. Sebastian Furness is from Adelaide and received his BSc(Hons) and PhD. from the University of Adelaide, in the biochemistry of gene regulation. He then did postdoctoral research on how blood stem cells regenerate all the different types of blood cells at the University of British Columbia in beautiful Vancouver before returning to Australia (this time in Melbourne) to work on the molecular functioning of an important class of drug targets called G protein-coupled Receptors. Sebastian won an ARC Future Fellowship, the most prestigious early-mid career fellowship for discovery scientists in Australia. This allowed him to develop his own research program where he moved to the University of Queensland, in sunny Brisbane. Sebastian runs a small lab that focusses on trying to understand the molecular-level details of how communication occurs between the gastrointestinal tract and brain. He teaches into undergraduate Biomedical Science and Pharmacy and enjoys communicating science in various forums, including “Pint of Science” and “The Conversation”. For more information on what the lab does see: RTClab.org AND https://biomedical-sciences.uq.edu.au/research/groups/receptor-transducer-coupling Author: Elena Koning Email: thinktwicepodcast@outlook.com Instagram: @thinktwice_podcast LinkedIN: Think Twice Podcast Patreon: https://www.patreon.com/ThinkTwicePodcast Disclaimer: Think Twice is a podcast for general information and entertainment purposes only. The content discussed in the episodes does not reflect the views of the podcast committee members or any institution they are affiliated with. The use of the information presented in this podcast is at the user's own risk and is not intended to replace professional healthcare services.
Send us a textAbout the guest: Nir Lipsman, MD, PhD is a neurosurgeon and neuroscientist at the University of Toronto.Episode summary: Nick and Dr. Lipsman discuss: neurosurgery; the blood-brain barrier and how it works; using focused ultrasound technology to non-invasively treat patients; regulatory impediments to clinical research; costs, constraints, and future applications of ultrasound tech for treating psychiatric conditions; and more.Related episodes:M&M #168: Sleep: Neural Circuits, Orexin/Hypocretin, Hypothalamus, Neuromodulators, Stress & Cortisol, Sleep Drugs & Ultrasound Technology | Luis de LeceaM&M #147: Ketamine: Opioid System, Sex Differences, S- vs. R- Isomers, Depression & Ultrasound Imaging Technology | Tommaso Di Ianni*This content is never meant to serve as medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off. SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Learn all the ways you can support my efforts
Did you know your diet could be the secret weapon for protecting your brain? In this video, Dr. William Li uncovers how certain foods can fortify one of your brain's most vital but overlooked defenses – the blood-brain barrier. This essential filter shields your mind from harmful invaders, yet many people don't realize how everyday foods can help keep it strong and effective.Prepare to rethink your daily meals as Dr. Li reveals how specific foods may boost memory, clear brain fog, and strengthen your brain's natural defenses. Watch now and discover how these small dietary changes can have a profound impact on your mental resilience and overall brain health.Listen to the full episode here.Watch the full episode on YouTube here.***Thank you to my wonderful sponsors!BON CHARGE | Science-backed beauty, wellness and recovery products.https://boncharge.com/LIVEWELL?rfsn=8119877.ae1cd73Use code LIVEWELL for 15% off.OptimallyMe | Personalised insights for optimal health.https://bit.ly/lwbw20Use code LWBW20 for 20% off.Squarespace | A website makes it real.http://squarespace.com/LiveWellGet a free trial and use code LIVEWELL for 10% off your first website or domain purchase
Dr. William Li is back on Live Well, Be Well!Mental health is a huge focus for me, and with good reason. Dementia's on the rise, and many people can resonate with the brain fog that comes as a consequence of our fast-paced world. But - did you ever think that being picky with food might mess with your mental health?Dr. William Li breaks down this new research for us, as we chat about how what we eat is so closely linked to our brain health. It's not just about food though - we get into the importance of moving your body, hanging out with friends, and that all-important thing called sleep.We also talk about ways to keep dementia at bay, with Dr. Li sharing some hopeful insights, as well as discussing the not so well known glymphatic system, which is like a brain car wash that only works when you're snoozing.Dr. William Li is a world-renowned physician, scientist, and author. His groundbreaking research has impacted over 70 diseases, including cancer, diabetes, heart disease, and obesity. He's one of the most sought-after medical experts in the field today.Let me know what you think, and don't forget to live well and be well!Sarah AnnHighlights:The Link Between Diet and Mental Wellbeing (0:00)Picky Eating Habits: New Research Reveals Surprising Mental Health Connections (0:52)Why a Varied Diet Matters for Mental Health (7:49)Exploring the Blood-Brain Barrier: Your Brain's Protective Shield (12:04)Mental Resilience: How Your Brain Adapts to Challenges (19:14)Brain Regeneration: Myth or Reality? Latest Findings Explored (25:06)Food as Medicine: Unlocking the Healing Power of Nutrition (36:07)Dementia and Alzheimer's: Understanding Risk Factors and Prevention Strategies (36:07)Move for Your Mind: The Brain-Boosting Benefits of Exercise (45:38)Why Social Connections Are Crucial for Brain Health (48:04)Sleep and Mental Health: The Science Behind a Good Night's Rest (49:19)A Glimpse into the Future of Medicine (1:03:41)Key Takeaways for a Healthier Brain and Body (1:08:57)***Thank you to my wonderful sponsors!BON CHARGE | Science-backed beauty, wellness and recovery products.Use code LIVEWELL for 15% off.OptimallyMe | Personalised insights for optimal health.Use code LWBW20 for 20% off.Squarespace | A website makes it real.Get a free trial and use code LIVEWELL for 10% off your first website or domain purchase.***If you enjoyed this episode you might also like:How to FIX Leaky Gut, Improve Health and Stop Cravings | Dr. James Kinrosshttps://youtu.be/YvupSI_S7_Q?si=_PnU0I87Ch-jkjXyDr. Will Bulsiewicz | Could SIBO be causing your IBS?https://youtu.be/m1bLLptcC2Q?si=8xyPDYXjtd39fXeG Nicole Vignola: The 7-Step Process to Rewire Your Brainhttps://youtu.be/JHn8z3w6AFQ How to FIX Leaky Gut, Improve Health and Stop Cravings | Dr. James Kinrosshttps://youtu.be/YvupSI_S7_Q ***Let's be friends!
Quick Notes:Now THIS is Gate Keeping - https://www.ohmtown.com/groups/mobble/f/d/dna-may-be-a-powerful-predictor-of-educational-success-new-research-suggests/Four Day Work Week - https://www.ohmtown.com/groups/hatchideas/f/d/does-working-a-four-day-week-make-you-happier/The Cost of a Stock Plunge - https://www.ohmtown.com/groups/mobble/f/d/nvidias-stock-plunge-cost-ceo-jensen-huang-almost-10-billion-in-a-single-day/Only Murders in the Building - https://www.ohmtown.com/groups/the-continuity-report/f/d/only-murders-in-the-building-renewed-for-season-5-at-hulu/Miniature Treadmills - https://www.ohmtown.com/groups/mobble/f/d/miniature-treadmills-accelerate-studies-of-insects-walking/What Lying Does - https://www.ohmtown.com/groups/nonsequiturnews/f/d/missing-13-year-old-found-in-adult-jail-after-lying-about-her-name-age-prosecutor/Banned for being Lippy - https://www.ohmtown.com/groups/four-wheel-tech/f/d/amazon-bans-its-drivers-from-moving-their-own-lips-too-much-at-work/Chipotle Unitards - https://www.ohmtown.com/groups/mobble/f/d/chipotle-unitards-are-coming/1000 Cupcakes didn't Check out - https://www.ohmtown.com/groups/nonsequiturnews/f/d/a-small-bakery-is-out-thousands-of-dollars-after-a-check-for-a-1000-cupcake-order-turned-out-to-be-a-scam/Nanoplastics and the Blood Brain Barrier - https://www.ohmtown.com/groups/mobble/f/d/nanoplastics-have-potential-to-cross-blood-brain-barrier-study-reveals/
In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations. Topics: 1. Introduction - Overview of Lyme disease and its causative agent, Borrelia burgdorferi. - Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB). 2. Understanding the Blood-Brain Barrier (BBB) - Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure. - Astrocytes: - Role in regulating blood flow through neurovascular coupling. - Interaction with neurons and release of vasoactive substances. - Contribution to BBB integrity by influencing tight junction formation. - Pericytes: - Contribution to BBB permeability and regulation through contractile capabilities. 3. Sponsor Break: Daily Nouri 4. Pathophysiology of Borrelia in the Brain - Invasion Mechanisms: - Borrelia's ability to adhere to and invade endothelial cells. - Role of surface proteins and induction of matrix metalloproteinases (MMPs). - Immune Evasion and CNS Invasion: - Antigenic variation to avoid immune detection. - Triggering of immune responses within the CNS, involving microglia and peripheral immune cells. - Cytokine production and its consequences on neuronal health. 5. Direct Impact on Brain Cells - Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis. - Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation. - Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions. 6. Sponsor Break: AX3 Life 7. Neurological Symptoms and Manifestations - Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS. - Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation. 8. Conclusion - Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach. - Recap of key points and reference to previous relevant episodes for further listening. Thank you to our episode sponsors: Check out Daily Nouri and use code CHLOE20 for 20% off your order. Check out AX3 Astaxanthin and use discount code CHLOE20 for 20% off your first order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Ep. # 119 On today's Pursuit of Wellness episode, Greg is back to dive into the details of our exciting NEW product, the Bloom energy drink! We'll explore the challenges of creating an energy drink, our commitment to balancing health and flavor, and a breakdown of the ingredients we chose and why. Together, Greg and I address the haters while providing motivation for female entrepreneurs. We also answer your questions on relationship advice, managing bad days, finding balance with each other, and provide fertility updates. Tune in for an intimate and personal episode with Greg and me! Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Greg's Instagram click here! For POW Brand Promo Codes click here! Sponsored By: Visit clearstemskincare.com and use code POW at checkout for 20% off your first purchase. Again, that's code POW for 20% off your first purchase on https://clearstem.com/ Get better sleep now with Blissy and use POWPOD to get an additional 30% off at blissy.com/POWPOD Sleep is the foundation of health, and there is nothing better than waking up feeling refreshed and ready to attack the day. Use code POW for 20% off your order at https://dreamrecovery.io/ Show Links: New Bloom Energy Drinks! Sucralose Bypasses the Blood Brain Barrier? New Research Shows Artificial Sweeteners Mess Up Your Gut? Topics Discussed: 00:11 - Welcome back Greg! 01:00 - Travel and lifestyle updates 03:20 - Phone “Check Ins” 04:28 - Greg's trip to LA 06:22 - Relationship advice and finding balance 09:21 - Fertility updates 10:38 - Greg's thoughts on expectations 15:19 - Bloom energy drinks 23:03 - Analyzing the ingredients in Bloom 31:45 - Greg's social media presence 32:45 - Key financial and investment advice 33:51 - Managing each other's bad days 34:51 - Mari's father and acclimating to America 38:26 - Fighting with each other 39:33 - Investments and getting acquired 39:38 - Relationship vs Mari's fitness journey 41:04 - Where to find Bloom energy drinks
On this episode Lara and Vyanka talk to Dr Matthew Campbell all about the blood brain barrier, what it is, how it works, how it's manipulated and the BBB in long COVID. This is ImmunoTea: Your Immunology Podcast, presented by Dr Lara Dungan and Dr Vyanka Redenbaugh. This is the show where we tell you all about the most exciting research going on in the world of immunology. So grab a cup of tea, sit down and relax and we'll fill you in. Contact us at ImmunoTeaPodcast@gmail.com or @ImmunoTea on twitter. Hosted on Acast. See acast.com/privacy for more information.
Dr. Ankush Bhatia interviews Dr. Keaton Piper about his and his team's manuscript, entitled "Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound", published online in Neuro-Oncology in May 2024 Read Paper
Join us for part 2 of BrainStorm's interview with Dr. Suzanne LeBlang, Director of Clinical Relations at Focused Ultrasound Foundation (www.fusfoundation.org). Host Meryl Comer and Dr. LeBlang discuss eligibility criteria and applications for the ground-breaking technology of focused ultrasound – a non-invasive procedure for treating tremors in Parkinson's disease and those newly diagnosed with Alzheimer's disease. This technological advancement can target and treat tissue deep within the brain, enhance drug delivery, and facilitate the removal of amyloid plaques. As featured on CBS 60 Minutes, patients are awake during this transformational procedure. You won't want to miss part 2 of this interview! Support the Show.
In this Hot Topic episode, Dr. Michele Matarazzo interviews Dr. Nir Lipsman on the Focused Ultrasound-mediated Blood-Brain Barrier Opening, from technical challenges to current evidence and future perspective of this promising technology that could provide a new way to deliver drugs in the brain.
Nearly everything toxic can end up at some point in time crossing the Blood Brain Barrier. Virtually every man-made toxin and poison on this planet can cross through the barrier, the sacred wall that mysteriously sits in our head. You go to the gas station, you start pumping gas into your tank and breathing in fumes, those fumes cross the Blood Brain Barrier. Or as you are driving an EV and are sitting on a very large battery and breathing in vapors that outgas off of car batteries, even if the battery is located in a different area of the car, small amounts of outgas occur over time and cross the Blood Brain Barrier. Everyday we get exposed from hundreds and hundreds of toxins. We get exposed to Pharmaceuticals, Toxic Heavy Metals, Pathogens, Pesticides, Herbicides, Fungicides, Solvents, Petrochemicals, Fragrances, Chemtrails and so much more, and as these exposures enter our bodies, they find a way to our brain by crossing the Blood Brain Barrier. We are led to believe it's very hard for any substance to cross the Blood Brain Barrier. We are told only certain pharmaceuticals can achieve crossing over the barrier purposely designed this way for our health, but it's so much more than what we are told. Listen to this surprising, powerful, informative Medical Medium podcast on the Blood Brain Barrier. For more information visit www.medicalmedium.com
Dr Fiona McLean, ARUK Research Fellow, University of Dundee is joined by fellow experts Dr Kate Harris and Dr Sophie Morse, to explore the intricacies of the blood-brain barrier and its pivotal role in dementia research. They discuss pioneering methods in overcoming the barrier for drug delivery, the significance of endothelial cells in barrier integrity, and novel approaches in treating neurodegenerative diseases. The conversation also touches on the collaborative nature of neuroscience, offering invaluable insights for newcomers to the field. Don't miss this deep dive into the forefront of dementia research. -- Meet the guests: Dr Sophie Morse is a Research Fellow & UK DRI Emerging Leader at Imperial College London, within the UK Dementia Research Institute. Sophie is a biomedical engineer who leads a research group exploring the use of Therapeutic Ultrasound for Brain Diseases. Dr Kate Harris is an Academic Track Alzheimer's Research UK Fellow in Drug Discovery at Newcastle University. Kate is working on finding new drug targets for neurodegenerative disease in neuroinflammation. -- Links mentioned in the show: Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain - https://bit.ly/41PFvuh -- Full biographies on all our guests and a transcript can be found on our website https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode – and if you prefer to watch rather than listen, you'll find a video version of this podcast on our website and YouTube Channel, with closed captions. https://youtu.be/1x_6ij9N6pU -- This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher
In this episode of the Backtable Podcast, guest host Dr. Paul Bhogal, a consultant interventional neuroradiologist at Royal London Hospital in the UK, and guests Dr. Piotr Walczak and Dr. Prakash Ambady discuss the potential of intra-arterial treatments combined with blood brain barrier (BBB) manipulation in treating various neurological conditions and tumors. The trio of doctors discuss methods such as the use of hyperosmolar mannitol and focused ultrasound to breach the BBB and deliver drugs directly to the brain tissue. Dr. Walczak and Dr. Ambady also highlight their individual research areas, including therapies involving cell delivery and engineered cells. The conversation also covers potential risks and new perspectives in comparison to current techniques such as whole-brain radiation. --- CHECK OUT OUR SPONSOR RADPAD® Radiation Protection https://www.radpad.com/ --- SHOW NOTES 00:00 - Introduction 05:44 - Challenges of Treating Glioblastoma Multiforme 12:52 - Understanding the Blood Brain Barrier 18:30 - Strategies to Negate the Blood Brain Barrier 20:52 - Blood Brain Barrier Disruption Using Intra-Arterial Mannitol 26:35 - Infusion Rates and Magnetic Resonance Guidance 33:47 - Role of Radiolabel Studies in Drug Delivery 36:31 - Future of Therapeutic Agents Design 47:54 - Potential of Focused Ultrasound in Drug Delivery 56:10 - Exploring the Use of Cells in Drug Delivery 58:44 - Future of Intra-Arterial Interventions --- RESOURCES Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma: https://pubmed.ncbi.nlm.nih.gov/15758009/ Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial: https://pubmed.ncbi.nlm.nih.gov/19269895/ REMOVAL OF RIGHT CEREBRAL HEMISPHERE FOR CERTAIN TUMORS WITH HEMIPLEGIA - PRELIMINARY REPORT: https://jamanetwork.com/journals/jama/article-abstract/254927 Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice: https://www.researchgate.net/publication/328537972_Real-Time_MRI_Guidance_for_Reproducible_Hyperosmolar_Opening_of_the_Blood-Brain_Barrier_in_Mice Dr. Piotr Walczak ResearchGate Profile: https://www.researchgate.net/profile/Piotr-Walczak-6 Dr. Prakash Ambday ResearchGate Profile: https://www.researchgate.net/profile/Prakash-Ambady Maculopathy Associated With Osmotic Blood- Brain Barrier Disruption and Chemotherapy in Patients With Primary CNS Lymphoma: https://pubmed.ncbi.nlm.nih.gov/32484895/ PET imaging of intra-arterial 89 Zr bevacizumab in mice with and without osmotic opening of the blood-brain barrier: distinct advantage of intra-arterial delivery: 10.2967/jnumed.118.218792 Safety of intra-arterial chemotherapy with or without osmotic blood–brain barrier disruption for the treatment of patients with brain tumors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307096/ Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances: https://pubmed.ncbi.nlm.nih.gov/25307218/
Have you ever considered how your stomach affects your brain? Dive into the gut-brain connection with Sara Barthel, a licensed dietician, Certified Nutrition Specialist, Gluten-free Practitioner, and Ironman triathlete who's personal health challenges led her to functional medicine and nutrition. We explore Sara's patient-focused approach to healthcare, as well as the neurological risks for ApoE4 carriers, widespread digestive challenges in Americans, and the effects of post-infectious IBS. Finally, we delve deep into food sensitivity tests and gluten's role in autoimmunity, and learn about Sara's detox methods and perspective on the "Bread and Other Edible Agents of Mental Disease." Tune in for her secret formula to reduce stress and optimize health. Episode Chapters:(0:00:01) - Healing the Gut and Brain Connection(0:09:02) - The Gut-Brain Connection and Digestive Disorders(0:14:55) - Lab Testing and Translating Results Discussion(0:21:28) - Gluten-Free and Food Sensitivity Testing Importance(0:36:42) - Post-Infectious IBS and Stress Management(0:43:42) - Detoxification and Mental Health Connection(0:48:06) - Coordinating Care Between Two Medical FieldsLinks:Vibrantvia.comJoin Over 18,000 Leading Medical Professionals and Become a Vibrant Wellness Provider Today!
Mark Litton, President and CEO of Athira Pharma, discusses advancements in treating neurodegenerative diseases, highlighting the challenges in treating these diseases. Athira's approach uses the body's natural repair mechanism to enhance the repair and protection of nerve cells. Their lead molecule, fosgonimeton, enhances the hepatocyte growth factor (HGF) and crosses the blood-brain barrier to effectively target neurodegeneration. Mark explains, "At Athira, we're taking a completely novel approach where we're using the body's natural repair mechanism to help repair. We have spent many years designing molecules that enhance this mechanism. This is what we call the HGF/MET biology. This is a biology that has been known for over 30 years. It was originally discovered coming from the liver. What we know about it is that it's important in repairing, protecting, healing, and developing nerve cells." "What we found in a lot of neurodegenerative diseases is that this repair mechanism is impaired, or it slows down as we get older. One of the keys is you've got a molecule, and it's HGF, and then it binds its receptor, the MET receptor. When it binds that receptor, that's when the cell gets activated and starts repairing. There are numerous factors that happen along the way. There are two places one could enhance the receptor. We've decided to enhance the HGF, the protein itself, to help it bind to its receptor." #Athira #Alzheimers #Parkinsons #Dementia #ALS #AD #PD #NeurodegenerativeDiseases #Neurodegeneration #NeuronalHealth #Caregivers #PatientCommunity athira.com Download the transcript here
Mark Litton, President and CEO of Athira Pharma, discusses advancements in treating neurodegenerative diseases, highlighting the challenges in treating these diseases. Athira's approach uses the body's natural repair mechanism to enhance the repair and protection of nerve cells. Their lead molecule, fosgonimeton, enhances the hepatocyte growth factor (HGF) and crosses the blood-brain barrier to effectively target neurodegeneration. Mark explains, "At Athira, we're taking a completely novel approach where we're using the body's natural repair mechanism to help repair. We have spent many years designing molecules that enhance this mechanism. This is what we call the HGF/MET biology. This is a biology that has been known for over 30 years. It was originally discovered coming from the liver. What we know about it is that it's important in repairing, protecting, healing, and developing nerve cells." "What we found in a lot of neurodegenerative diseases is that this repair mechanism is impaired, or it slows down as we get older. One of the keys is you've got a molecule, and it's HGF, and then it binds its receptor, the MET receptor. When it binds that receptor, that's when the cell gets activated and starts repairing. There are numerous factors that happen along the way. There are two places one could enhance the receptor. We've decided to enhance the HGF, the protein itself, to help it bind to its receptor." #Athira #Alzheimers #Parkinsons #Dementia #ALS #AD #PD #NeurodegenerativeDiseases #Neurodegeneration #NeuronalHealth #Caregivers #PatientCommunity athira.com Listen to the podcast here
Weight loss can be a tricky thing for a lot of people because it is hormonal based. If you want to lose weight there are 3 phases to doing it in a healthy way. The first phase is the transition to restore metabolism. Once that is established then the second phase is when the body starts losing weight. The third and final step is to maintain optimal health and keep the weight off. Dr. Armitstead explains in this podcast how your hormones will change in response to the nutrition and lifestyle changes that you'll make. Your body will also rebuild at the cellular level with nutrients that were not available during previous poor habits. The more damaged the current metabolism, the longer it will take for this process to be complete. Once someone has healed their metabolism, only then they are primed to lose fat and move on to phase two. You will learn why some people take longer than others to lose weight. Those that take the longest are said to be weight loss resistant. Resources:Berberine helps lower high blood pressure https://pubmed.ncbi.nlm.nih.gov/33461163/#:~:text=A%20proprietary%20nutraceutical%20containing%20berberine,dietary%20advice%20MCT oil and weight loss https://healingartsnyc.blogspot.com/2019/01/the-health-benefits-of-mct-oil.html
Why is GABA, a neurotransmitter that's vital for regulating our feelings, emotions, thoughts, and experiences, often overlooked in the world of neuroscience? In this episode of the Biohacking Superhuman podcast, I ponder this question with Dr. Scott Sherr, a repeat guest, who unravels the mystery surrounding GABA's key role in our mental well-being. We venture into the complex labyrinth of the GABA system, elucidating its significance in controlling the firing of neurons, its connection to a leaky blood-brain barrier, and the implications for those of us entrenched in the hustle and bustle of life. Dr. Sherr and I also put under the microscope the intriguing world of supplements and drugs. We peel back the layers on how they interact with the GABA system and the potential mental health risks they harbor. From the influences of alcohol, Xanax, barbiturates, and sleep drugs on the GABA system to natural alternatives, we left no stone unturned. Moreover, if you're on SSRIs, you might find our explorations on supporting the GABA system and rebalancing emotions, thoughts, and feelings very enlightening. In the concluding part of our conversation, we touch upon the intriguing effects of nicotinol GABA, THC, and CBD. We assess the potential benefits of Trozzy, an innovative sleep aid supplement. As the saying goes, 'Sleep is the golden chain that ties health and our bodies together.' Therefore, we also shed light on the importance of good sleep habits and natural ways to enhance the GABA system. Join us for this exciting conversation with Dr. Sherr, and get a deeper understanding of how to optimize your brain's functioning and mental health. Visit https://troscriptions.com/ and use code NAT10 to save. Thank you to our sponsors for making this episode possible: Paleovalley: Use the link paleovalley.com/nathalie for 15% off Carol Bike: Visit carolbike.com and use promo code NAT for $100 off. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Sherr: Website: https://troscriptions.com/ and https://home-sf.co/ Instagram: https://www.instagram.com/drscottsherr/ What we discuss: (0:00:03) - GABA's Importance in Brain Function (0:04:00) - Exploring Gaba and the Blood-Brain Barrier (0:10:55) - Understanding the GABA System (0:22:38) - GABA Compounds' Impact on Mental Health (0:27:36) - SSRIs and the GABA System (0:33:13) - GABA's Effects on the Brain (0:47:37) - THC/CBD Impact on GABA System (0:51:19) - Introducing Trozzie (0:58:42) - Enhancing GABA System and Sleep Habits Key takeaways: About 20% of our neurotransmission is GABA. While GABA is all over the brain, they're also in a place that are called interneurons. Interneurons are these waystations between neurons that help regulate the processing of information, both downwards and upwards. This is extremely important for how we regulate our emotions, how we regulate our feelings, how we regulate our interactions with other people, and then how we process our thoughts, how we process our experiences, both in the now and also in the past and the future. We may not realize it, but a lot of us are actually GABA deficient. GABA deficiency is a big deal because it's associated with depression, anxiety, and compulsive disorder. It's potentially contributing to things like schizophrenia, mental illness, and alcoholism. We know that SSRIs work on some level to help with mood regulation. However, they do not work right away. It requires anywhere from four to eight weeks for the antidepressant effects to kick in. On the other hand, GABA compounds work right away and elevates your mood.
In this episode, we review the high-yield topic of Blood-Brain Barrier from the Gastrointestinal section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
If you're looking to improve your circulation / blood flow and athletic performance or simply combat increased vascular permeability (which can create edema and, therefore, hypoxia) due to the damaging effects of hyperglycemia, inflammation, toxins, etc..., then this episode is a MUST-listen! We're delving into the intricacies of the vesugen bioregulator peptide – so stay tuned for some pretty intriguing research! Topics: 1. Introduction to the Episode - Previous background interest in vesugen: Lyme and Mold / CIRS issues - Introduction to bioregulator peptide vesugen - Effects on blood vessels, circulation, hypoxia, and athletic performance 2. Quick Overview of CIRS and the Circulatory System - Damage to the endothelial blood vessel wall due to high MMP-9 levels - Hemolysins released by MARCoNS - Narrowed capillaries and induced hypoxia - Interest in vesugen 3. Blood Cell Formation - Hematopoiesis - Process and origin in the bone marrow - Characteristics of multipotent hematopoietic stem cells (HSCs) - Regulation of HSC self-renewal vs. differentiation - Myeloid and Lymphoid Progenitors - Differentiated blood cells from each progenitor type - Pathway: Myeloid progenitor to erythrocyte - Role of Erythropoietin (EPO) 4. Maturation Process of Erythrocytes - Ejection of nucleus and organelles - Hemoglobin acquisition - Biconcave shape for optimal gas exchange - Transition to the bloodstream via sinusoids 5. Vascular Wall Anatomy and Dysfunction - Overview of vascular wall layers: Tunica intima, tunica media, and tunica externa - Detailed understanding of endothelial cell functions - Barrier function and vascular permeability - Vascular tone and blood flow regulation - Inflammation and the role in immune response - Angiogenesis and its significance 6. Bioregulator Peptide Vesugen - Definition and unique characteristics - Composition: Lysine, Glutamine, and Asparagine - Mechanism of action: Promotion of endothelial cell proliferation 7. Benefits and Potential of Vesugen - Restoration of endothelial function - Role in injury and endothelial dysfunction scenarios: edema, hypoxia, etc... - Protective effect on the blood-brain barrier - Impact on nitric oxide production and athletic performance, hair growth, skin health Thanks so much for tuning in! Pre-Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Ready to step into the future of the medical field? Join us as we journey through the cutting-edge biomarker-based diagnosis, a revolution set to transform the lives of Alzheimer's patients, and take a deep dive into the booming trend of eco-conscious business investments.We'll also explore the seismic shifts in the investment landscape, analyze the transformative power of AI in the investment sector, and give you some expert tips on incorporating this game-changing technology into your portfolio. Plus, we touch on the potential release of a spot Bitcoin ETF; stay informed with our free white paper, "What You Need to Know About Spot Bitcoin ETFs".Subscribe to podcast updatesAsk Ric | Ric's Books-----Links from today's show:What You Need to Know About Spot Bitcoin ETFsWhat Are Biomarkers and Why Are They Important?Global X Clean Tech ETF (Symbol: CTEC)Follow Ric on social media:Facebook | Instagram | LinkedIn | X (formerly Twitter) | YouTubeBrought to you by:Global X ETFsInvesco QQQPrisidioSchwabDisclosure page-----
The Real Truth About Health Free 17 Day Live Online Conference Podcast
Plastic And The Poisons It Carries Is Getting Through The Blood Brain Barrier Into All Of Our Brains Stephanie Seneff, PhD • https://people.csail.mit.edu/seneff/ • Book - The Glyphosate Effect Jeffrey M. Smith • http://responsibletechnology.org/ • Book - Seeds of Deception Andre Leu • contact: linkedin.com/in/andre-leu-a365861a • Growing Life: Regenerating Farming and Ranching Julian Cribb • http://www.juliancribb.net • Book – Earth Detox (How and Why we Must Clean up Our Planet) Ronnie Cummins • http://www.organicconsumers.org • Book - Grassroots Rising Joanna Malaczynski-Moore • http://www. JoannaMoore.com • Book – Silent Winter #GMO's #Chemicals #FoodSystem #AffectingYourHealth Dr. Stephanie Seneff is a Senior Research Scientist at the MIT Computer Science and Artificial Intelligence Laboratory and author of the recently published book; Toxic Legacy: How the Weedkiller Glyphosate Is Destroying Our Health and the Environment. Dr Seneff presents mounting evidence that the active ingredient in the world's most commonly used weedkiller is contributing to skyrocketing rates of chronic disease. Glyphosate is the active ingredient in Roundup, the most commonly used weedkiller in the world. Nearly 300 million pounds of glyphosate-based herbicide are sprayed on farms—and food—every year. In 2012, Dr. Seneff was elected Fellow of the International Speech and Communication Association (ISCA). To Contact Dr Stephanie Seneff go to stephanieseneff.net Jeffrey Smith delivers transformational communication on a global scale. A bestselling author, award-winning filmmaker, celebrated public speaker, and penetrating interviewer, his work has influenced the behavior and health of millions of people worldwide. The majority of Americans now understand that GMOs are unsafe, and the food industry is responding by removing them. Jeffrey is sought after as an inspirational keynote speaker and hosts the Live Healthy Be Well podcast. To Contact Jeffrey Smith go to: ResponsibleTechnology.org Andre Leu is the Author ofseveral books including his most recent; Growing Life: Regenerating Farming and Ranching. This book is about modern farming and ranching evolve away from mass consolidation and industrialization, a new strategy is rapidly emerging: regenerative agriculture. These new systems being implemented across the globe require a shift in the mindset of the land manager and operator, away from being primarily reliant on external inputs such as fertilizers and pesticides, and toward dependence on knowledge, measurement and management. You Can contact Andre Leu on Twitter and Linkedin Julian Cribb is an Australian author and science communicator. He is a fellow of the Royal Society for the Arts, the Australian Academy of Technological Science (ATSE) and the Australian National University Emeritus Faculty. He is a Member (AM) of the Order of Australia (General Division) His published work includes over 9000 articles, 3000 science media releases and eight books. He has received 32 awards for journalism. To Contact Julian Cribb go to juliancribb.net Ronnie Cummins is an author of the book; Grassroots Rising: A Call to Action on Climate, Farming, Food, and a Green New Deal and has spent over 50 years as a professional activist starting with anti-war activism . Grassroots Rising: A practical, shovel-ready plan for anyone wondering what they can do to help address the global climate crisis. To Contact Ronnie Cummins go to organicconsumers.org Joanna Malaczynski-Moore is sustainability entrepreneur, consultant, advocate, attorney and acclaimed author to the book Silent Winter and upcoming book Another Way: Navigating toward positive change. Silent Winter Our Chemical World and Chronic Illness is about the silent spread of toxic chemicals in our daily lives and their role in the growing prevalence of illnesses such as cancer, chronic fatigue, diabetes, asthma digestive issues, depression, dementia, and others. To Contact Joanna Malaczynski-Moore Go to JoannaMoore.com Disclaimer:Medical and Health information changes constantly. Therefore, the information provided in this podcast should not be considered current, complete, or exhaustive. Reliance on any information provided in this podcast is solely at your own risk. The Real Truth About Health does not recommend or endorse any specific tests, products, procedures, or opinions referenced in the following podcasts, nor does it exercise any authority or editorial control over that material. The Real Truth About Health provides a forum for discussion of public health issues. The views and opinions of our panelists do not necessarily reflect those of The Real Truth About Health and are provided by those panelists in their individual capacities. The Real Truth About Health has not reviewed or evaluated those statements or claims.
When faced with an unwanted situation have you ever noticed that your mind goes to worse case scenario or down a rabbit hole of ‘what ifs'? When the mind is behaving crazy it's running ancient programs belonging to the limbic brain that focuses on survival and fear. To change this and stop the limbic brain from running the ancient programs we need to cut off it's supply of sugar. In this podcast Dr. Armitstead explains what changes to make to change brain chemistry and neural pathways to help with anxiety, depression, PTSD, and moodiness. If you are stuck in anxiety or have a fear you know is holding you from your best life know that there is a way to reprogram your neural pathways and help your brain health by detoxifying the brain, supporting the brain with good nutrition, implementing good stress management and doing PSYCH-K®.PSYCH-K® is an energy-balancing technique to help individuals transform their subconscious beliefs. It uses techniques such as visualizations, affirmations, and muscle testing to help reprogram the subconscious mind and create new neurological pathways.Reference LinksBrain increases brain volume: https://europepmc.org/article/MED/16763039 To write a better life story: https://healingartsnyc.blogspot.com/2016/05/life-is-story.htmlPSYCH-K®: https://healingarts.buzzsprout.com/894679/3985814-psych-k-and-morePoisons and the Blood Brain Barrier: https://healingarts.buzzsprout.com/894679/4731317-poison-and-the-blood-brain-barrier
Elliot and Dan teamed up for the podcast this week, bringing you the week's sweetest hacks. And news too, as the ESA performed a little percussive maintenance on a Jupiter-bound space probe, and we learned about how to get an Orwellian free TV that exacts quite a price. We talked about Bitcoin mining two ways, including a way to put all that waste heat to good use -- just don't expect it to make good financial sense. Why would you stuff zip ties into a hot glue gun? It might just help with plastic repair. Lugging a tube transmitter up a mountain doesn't sound like a good idea, but with the right design, it's a lot of fun -- and maybe you'll be better able to tap into Schumann resonances while you're up there. Check out the links and tell us what you think about this episode in the comments!
What is in the This Week in Science Podcast? This Week: Quantum Microscopes, Textbooks in India, Photosynthesis, Aliens, Aminos, Frogs, Seals, Ice Caps, Blood Brain Barrier, Brain Reading, Anorexic Guts, UTIs, And Much More Science! Become a Patron! Check out the full episode of our science podcast on YouTube or Twitch. And, remember that you can find […] The post 3 May 2023 – Episode 924 – May the 4th has Quantum Microscopes! appeared first on This Week in Science - The Kickass Science Podcast.
On today's podcast Dr. Elias Sayour will talk about his goals to help in the fight to cure the most aggressive forms of Pediatric Brain Cancer. Dr. Sayour will discuss some of the most important topics in this fight including overcoming the Blood Brain Barrier , the dynamics of Brain Cancers as they respond to treatment, how Immunotherapy can be such an important addition to help win these battles, and the optimism that he shares as to the future for these kids who are dealing with such an unfair situation.
The Patriotically Correct Radio Show with Stew Peters | #PCRadio
There are no official safety standards for 5G tech, there are only guidelines. Dr. Beverly Rubik joins Stew to talk about how 5G can disrupt the tissue structures inside the human body. 5G can produce oxidative stress, changes in cell membranes, DNA damage, nervous system problems, and reproductive harm. As 5G technology blankets across the earth it will terraform it into an electromagnetic hell scape. Former President Trump may be headed to a jail cell very soon while the Biden crime family flourishes. Francis A. Boyle is here to talk about his bill to impeach Joe Biden which is has been in the hands of the freedom caucus since July of 2022. The U.S. Military Reaper drone that was sent to the Black Sea was an illegal act of hostility. The media and global criminal cabal are blaming the plandemic on Chinese raccoon dogs. Eric Coppolina is here to talk about the pathetic attempt to cover up the release of the Covid-19 bioweapon by blaming the outbreak on a little known “raccoon dog”. The dispute over whether Covid came from a lab or a wet market is a fake argument designed to support viral scientific concepts. Protect your family from dangerous spike proteins and learn about the new “Z Care” by heading over to http://HeroicDoctors.com Dr. Ben Marble joins Stew to talk about Z-Stack and how if you use it and still get sick they will pay for your doctor's visit. Simone Gold is back in the news because America's Front Line Doctors has released a new report detailing her lavish spending habits. If Simone Gold is guilty of stealing donors' money to enrich herself she should go to prison. Watch this new show NOW at Stewpeters.com! Keep us FREE and ON THE AIR! SUPPORT THE SPONSORS Below! Get High Quality Prepper Food, NOW with $100 Buckets! Use Promocode STEW for Big Discounts at https://HeavensHarvest.com Taxation is THEFT! Never again voluntarily pay the Washington D.C. Swamp, legally and safely, GUARANTEED when you attend Freedom Law School! Visit: https://FreedomLawSchool.org Protect your retirement, Visit our friends at Goldco! Call 855-706-GOLD or visit https://goldco.com/stew Clean up your AIR with these high quality air filtration systems, and protect yourself from shedding: https://thetriadaer.com/ Support anti-vax activism, free clinic care, and MANLY products like IGF1 visit:https://Vaccine-Police.com Check out https://nootopia.com/StewPeters for help increasing your mental & physical strength to battle the deep-state's KRYPTONITE plot against Americans! Magnesium is VITAL for sleep and stress, Get high quality magnesium and support the show with using Promocode STEWPETERS10: https://magbreakthrough.com/stewpeters Check out: https://kuribl.com/ STEW20 for 20% off your order or premium CBD! Prepare your family for famine and shortages by purchasing food through: https://heavensharvest.com/ Eat Carbs and LOSE WEIGHT, Check out MCT: https://thehealthyfat.com/stew From spy balloons to saber rattling, does China hold a deadly secret that would cripple our country beyond recognition? America's biggest threat in 2023. This documentary https://darkagedefense.com/stewpeters exposes the truth!! Go Ad-Free, Get Exclusive Content, Become a Premium user: https://www.stewpeters.com/subscribe/ Follow Stew on Gab: https://gab.com/RealStewPeters See all of Stew's content at https://StewPeters.com Check out Stew's store: https://stewmerch.com
Dr. Axel Montagne is a chancellor's fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline. With this knowledge, they hope to develop precise treatments targeting brain vasculature to protect brain function. More importantly his work, and that of his colleagues, provide a critical lens through which to view the contributions of vascular dysfunction (or, conversely, vascular health – if we choose to preserve it) as a critical common thread in dementia and neurodegeneration. In this episode, we discuss: 11:44 - What dementias have in common 12:42 - The importance of preserving small blood vessels (in the brain) 13:38 - Changes in the blood-brain barrier in aging that cause "leaking" 15:11 - Predicting cognitive decline early with biomarkers – an opportunity for intervention? 16:32 - Why targeting amyloid isn't enough 18:54 - The impact of the APOE4 genotype on brain vasculature 24:19 - The cause of white matter damage in the brain 33:47 - Why the loss of omega-3 transport affects pericytes 35:25 - The role of exercise in prevention of blood-brain barrier dysfunction 35:45 - Why high heart rates during exercise preserve brain function 36:49 - The role of exercise in preserving vision health 40:17 - Why leaky vessels damage myelin and the brain 45:31 - Can you have more than one type of dementia? 47:54 - Does the breakdown of the blood-brain barrier cause “type 3 diabetes"? 54:03 - Why omega-3 may prevent detachment of pericytes 01:14:35 - Why a hepatitis drug restored cognition in APOE4 mice 01:19:39 - Why blood-brain barrier disruption results in the accumulation of amyloid-beta 01:25:14 - Why lifetime hypertension increases dementia risk 01:37:13 - Effects of obesity on blood-brain barrier leakage Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot
Welcome to Season 5 of Living Well with MS, where we are pleased to welcome holistic health practitioner and expert Magic Barclay as our guest! Keep reading for the key episode takeaways and Magic's bio. Make sure you sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. And if you're new to Overcoming MS, visit our introductory page to find out more about how we support people with MS. Bio: Magic Barclay is the lead practitioner and founder of ‘Wholistic Natural Health Australia', a holistic health practice. She also is a host of the podcast “A Magical Life: Health, Wealth and Weight Loss”. Magic's life changed when she faced multiple life-threatening conditions and at the same time, found herself divorced and raising her two children alone. She decided to find the root cause of her health issues and that set her on a path of life-changing learning that affected her whole family. Magic is a Master Practitioner in immune health, mould toxicity recovery and Psycho-Neuro-Endocrine-Immunology (the study of the interaction between psychological processes and the nervous and immune systems of the human body) of trauma. She tells us that she is a “mum of two amazing humans and two gorgeous furbabies, a grower of organic food for her family and a passionate native gardener”. Magic's mission is to help people heal naturally, reconnect to the environment and reach their own potential. She mainly works with women aged 45-65 who feel unheard or misled by mainstream medicine and anyone who wants to bring their health back to basics. Selected Key Takeaways: The purpose of functional medicine Functional medicine involves looking at the systems of the body. It looks at what each system does and how it works with the other systems. We often say, "no system works alone." We particularly look at the root cause because if you don't look at that, then other issues keep arising. Belief in yourself is a powerful part of healing If people don't believe in themselves, they're not going to get well. We see a lot of people just given diagnosis after diagnosis, label after label, and they start believing that's who they are. Magic believes that this is a really awful way to live because you're a person, you are not the label that was given to you by your doctor. You are still a person. So, what they do in functional medicine is uncover: Who is that person? And who do [they] want to be? Reduce stress by acknowledging the stressor isn't forever If you find yourself around people that increase your stress, don't be around them or decide to be around them for five or 10 minutes. Give yourself a time cap and tell yourself after 10 minutes “I'm out of this situation and I'll be okay”. If you find you are stressed by work, a doctor's appointment or driving, either take yourself out of the situation, find an alternative, or give yourself a time limit so that you know internally it's not forever. And don't sit there thinking, “I'm so stressed,” as your body hears that and guess what? It replies, "Really? This is a low level of stress, you want to be stressed? I'll raise the bar." Related Links: Magic's Wholistic Natural Health Find out more about PNEI and Dr. Gabor Maté https://drgabormate.com/ Make natural laundry detergent from horse chestnuts/ conkers/ buckeyes https://wastelandrebel.com/make-laundry-detergent-out-of-chestnuts/ Parkinson's protein from gut to brain https://www.nih.gov/news-events/nih-research-matters/tracking-spread-parkinsons-proteins-gut-brain The Blood Brain Barrier in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395058/ Th1 and Th17 response in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491887/ Don't miss out: Subscribe to this podcast and never miss an episode. You can catch any episode of Living Well with MS here or on your favourite podcast listening app. If you like Living Well with MS, please leave a 5-star review on Apple Podcasts or wherever you tune into the show. Feel free to share your comments and suggestions for future guests and episode topics by emailing podcast@overcomingms.org. Make sure you also sign up to our newsletter to hear our latest tips and news about living a full and happy life with MS. If you enjoy this podcast and want to support the ongoing work of Overcoming MS, you can leave a donation here.
Dr. Sara Schaefer discusses with Dr. Pineda-Pardo using focused ultrasound to temporarily open the striatal blood brain barrier in Parkinson's disease dementia patients, and the implications for the results of this safety and feasibility study including for future treatment options for these patients. Journal CME is available until December 1, 2023 Read the article.
Taking a minor break from ruffling the f*cking cages and feathers of what we call modern society these days and I wanted to talk about something a bit more conventional but important nevertheless and that is sleep. I have a multitude of studies for you to do your own research as I want to present this topic as clear cut as possible. Time Stamps: (0:28) Are You Enjoying the Podcast? (2:30) Going On a Journey With Sleep (6:40) Adverse Effects From Poor Sleep (16:30) Stress and the Blood-Brain Barrier (18:50) Naps ---------------------------- Resources: [i] Pilcher JJ, Walters AS. How sleep deprivation affects psychological variables related to college students' cognitive performance. J Am Coll Health. 1997 Nov;46(3):121-6. View Abstract [ii] Walker MP, et al. Practice with sleep makes perfect: sleep-dependent motor skill learning. Neuron. 2002 Jul 3;35(1):205-11. View Abstract [iii] Rosen IM, et al. Evolution of sleep quantity, sleep deprivation, mood disturbances, empathy, and burnout among interns. Acad Med. 2006 Jan;81(1):82-5. View Abstract [iv] Cohen S, et al. Sleep habits and susceptibility to the common cold. Arch Intern Med. 2009 Jan 12;169(1):62-7. View Full Paper [v] Patel SR, et al. Association between reduced sleep and weight gain in women. Am J Epidemiol. 2006 Nov 15;164(10):947-54. View Full Paper [vi] Donga E, et al. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab. 2010 Jun;95(6):2963-8. View Abstract [vii] Williamson AM, Feyer AM. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occup Environ Med. 2000 Oct;57(10):649-55. View Full Paper [viii] Kim TW, Jeong JH, Hong SC. The impact of sleep and circadian disturbance on hormones and metabolism. Int J Endocrinol. 2015;2015:591729. View Full Paper [ix] Vgontzas AN, et al. IL-6 and its circadian secretion in humans. Neuroimmunomodulation. 2005;12(3):131-40. View Abstract [x] Meier-Ewert HK, et al. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clin Chem. 2001 Mar;47(3):426-30. View Full Paper [xi] Meier-Ewert HK, et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004 Feb 18;43(4):678-83. View Abstract [xii] van Leeuwen WM, et al. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS One. 2009;4(2):e4589. View Full Paper [xiii] Chennaoui M, et al. Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-α) levels in healthy men. Cytokine. 2011 Nov;56(2):318-24. View Abstract [xiv] Vgontzas AN, et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 2002 Jul;51(7):887-92. View Abstract [xv] He J, et al. Sleep restriction impairs blood-brain barrier function. J Neurosci. 2014 Oct 29;34(44):14697-706. View Full Paper [xvi] Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008 Jan 24;57(2):178-201. View Abstract [xvii] Hurtado-Alvarado G, et al. Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link. J Immunol Res. 2016;2016:4576012. View Full Paper [xviii] Esposito P, et al. Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress. J Pharmacol Exp Ther. 2002 Dec;303(3):1061-6. View Full Paper [xix] Steiger A. Sleep and the hypothalamo-pituitary-adrenocortical system. Sleep Med Rev. 2002 Apr;6(2):125-38. View Abstract [xx] Vgontzas AN, et al. Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E253-61. View Full Paper ---------------------------- Follow Me on Instagram! @tayloredwellbeing ---------------------------- Click Here to Apply to Work with Me or visit taylorsappington.com/application
This is episode 2 in the phenomenal BRAIN POWER SERIES. Let me unpack the Blood Brain Barrier (BBB) in simple terms and tell you why it's so important to your overall health and wellness. Then we'll get into the 3 B's of Optimal Brain Health to keep you sane and happy this holiday season! BETTER DIET BETTER BEVERAGES BETTER HABITS It's never too late to start doing what is right! SAVE TIME!!! Be sure to snag your FREE downloadable that goes with this episode and includes the 3 B's PLUS a one-page must have grocery list for shopping made simple! I'll also link some of my favorite products! *CHOOSE 2 THINK: Find Peace, Joy, Hope, Health & Freedom Every Day! Your 365-day DEVOTIONAL. Peek Inside Here. FREEBIE companion tool for the Choose 2 Think Devotional CONNECT WITH VICTORIA: EMAIL: choose2think@gmail.com WEBSITE MENTORING ONLINE COURSES YOUTUBE FACEBOOK INSTAGRAM --- Send in a voice message: https://anchor.fm/victoria-walker-lydon/message Support this podcast: https://anchor.fm/victoria-walker-lydon/support
"The best way to think about insulin resistance is that it's pre-diabetes. In the course of developing type 2 diabetes, which we see in much higher rates in people with bipolar disorder compared to the general population, one starts off with normal blood sugar levels but elevated insulin. It is the elevated insulin that pushes the blood sugar down into the normal range. This is typically something that is missed by physicians because there's been no medical indication to test for it [insulin level]. After the metabolic dysregulation progresses, patients become glucose intolerant, and at that point a doctor may pick up on it because the blood sugar is elevated - not elevated such to say that they have type 2 diabetes but elevated into the glucose intolerant range." Episode Description: We begin by describing the symptoms of Bipolar Disease and the reasons that make it important to distinguish from depression. We consider the value of measuring insulin levels to determine if there is a contribution of metabolic dysfunction on the course of the psychiatric condition. Over 50% of patients with Bipolar Disease have insulin resistance and those who do, have a more chronic course of illness. We discuss the role of cortisol levels, chronic inflammation, adverse childhood events, and leakage in the Blood Brain Barrier. Metformin is a safe and useful medication that can reverse insulin resistance and remedy Blood Brain Barrier leakage as documented on radiologic assessment. We conclude with Cindy sharing with us her history as a Family Physician and her hope for appreciating the role of metabolic dysregulation in other psychiatric conditions. Our Guest: Cindy Calkin, MD is a clinical researcher and Associate Professor of Psychiatry and Medical Neuroscience at Dalhousie University, Canada. She is the Medical Director of a unique multidisciplinary clinical research Mood and Metabolism Program that includes psychiatry, endocrinology and metabolism, health physics, biomedical engineering, neuroradiology, and medical neuroscience. Her group uses multimodal testing to collect detailed prospective data. Her innovation and discovery research focuses on mechanisms underlying Treatment-Resistant Bipolar Depression (TRBD) and novel mechanism-based targeted treatments.
Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, this is a great place to start! Sections in this episode: Cardiovascular Risk Factors (3:45) White Matter Hyperintensities (8:51) Cerebral Amyloid Angiopathy and the Blood-Brain Barrier (15:47) Therapeutic Avenues (24:00) -------------------------------------------------------------- To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:https://drive.google.com/file/d/1Gswzf5F_ptPPY2OVH3Qdk15aZpNMyaIo/view?usp=sharingTo access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharingYou can also find all of our bibliographies on our website: www.amindr.com. --------------------------------------------------------------Follow-up on social media for more updates!Twitter: @AMiNDR_podcastInstagram: @AMiNDR.podcastFacebook: AMiNDR Youtube: AMiNDR PodcastLinkedIn: AMiNDR Podcast Email: amindrpodcast@gmail.com -------------------------------------------------------------- Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don't forget to subscribe to hear about new episodes as they come out too. Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/. Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Elyn Rowe, edited by Chihiro Abe, and reviewed by Cassi Friday and Judy Cheng. The bibliography was created by Lara Onbasi and the wordcloud was created by Sarah Louadi (www.wordart.com). Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer's Disease papers into episodes each month. For July 2022, the sorters were Sarah Louadi, Eden Dubchak, Ben Cornish, Ellen Koch, Dana Clausen, Christy Yu, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Lara Onbasi for keeping everything running smoothly.Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic. https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w -------------------------------------------------------------- If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways. --------------------------------------------------------------*About AMiNDR: * Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"
Stan Abel is the Chief Executive Officer of ProJenX, working on developing therapeutics to get into the brain to access the motor neurons that are dying in ALS and other brain and neurological diseases. Their drug prosetin is optimized to be bioavailable and administered in a small amount of liquid which is an advantage to someone living with ALS. Research is showing promise in increasing motor neuron survival in other neurodegenerative diseases like Parkinson's and perhaps Alzheimer's. Stan explains, "In ALS, we need the therapeutics to get into the brain to access the motor neurons where the pathology is taking place and where those motor neurons are dying. The team at Columbia actually optimized a family of compounds. Not only were they screening these drugs to see that they were neuroprotective, and in these ALS models, they could see that we were actually really improving the survival of motor neurons in vitro, which means basically in a Petri dish. They optimized the compound so that it would easily cross the blood-brain barrier." "These are two really important aspects. I think the advantage, in fact, that ProJenX has and prosetin has versus other programs that have been advanced in ALS is that this drug, all along the way, was based on ALS disease pathology. It was then was optimized to actually get into the brain and access the motor neurons that need the help." @ProJenX #ProJenX #ALS #ProjectALS #NeurodegenerativeDiseases #BrainDiseases #BloodBrainBarrier #ColumbiaUniversity projenx.com Download the transcript here
An ingredient allegedly used in the COVID-19 vaccines is patented to help medications break through the blood-brain barrier, and the presence of this ingredient could pose a threat to the health and safety of the U.S. military, according to Dr. Samuel Sigoloff, a major in the U.S. Army and a whistleblower. We speak with Dr. Sigoloff about his findings, his attempts to alert the U.S. military amid the vaccine mandates, and how he was punished for issuing his warnings. ⭕️ Stay up-to-date with Josh with the Crossroads NEWSLETTER
Neurologist/Neuro-oncologist in Cleveland Clinic's Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Glen Stevens, DO, PhD, joins the Cancer Advances podcast to talk about the treatment of recurrent glioblastoma. Listen as Dr. Stevens discusses how a study mixing old principles with a new technique may disrupt the BBB, allowing chemotherapy to reach tumor cells.
Anxiety was escalating at a rapid rate before 2020, and now it's just crazy. Long-haulers, mandates, lockdowns, wars, masks, headlines, our kids.....let's just say it isn't expected to get any better anytime soon, hence counseling services are increasing, doctors visits and prescriptions are increasing, but so are people searching for information and trying to solve their anxiety puzzle without medications, on their own. There are tons of options for medications, supplements, and general advice out there - where do you turn and what do you do?? Understand the mechanisms of anxiety, neuroinflammation, and autoimmunity. UNDERSTANDING MECHANISMS PROVIDE SOLUTIONS!I have at least 20 things in my Vitamin Store that I have used in my clinic that have helped people tremendously with anxiety, including magnesium, CBD, L-theanine, B6 and other B vitamins, keto diet, avoiding gluten or dairy, binders, methyl donors, sauna, herbs for pathogens, probiotics, adaptogens, vagus nerve stimulation. Some of these people were mold, Lyme, EBV, IBS, or autoimmune disease patients with a list of 10+ other symptoms, but some were kids, moms, dads, people who just dealt with a lot of anxiety but otherwise had few complaints. It can happen to anybody. What are the mechanisms for YOU?? Here is a list of 10 things you need to know about when searching for the next clue to solve your health puzzle:1. Mitochondria - the batteries behind it all!! Also the cause behind it all.....listen to episodes 30, 31, 32 for more info on mitochondria but you have a QUADRILLION of them in your brain, so they are kinda important.....2. Brain Cells - Neurons vs. Microglia vs. Mast Cells vs. Astrocytes.....you don't need to know everything, but a little bit about each one can help!3. Brain Regions - limbic regions - amygdala, insula, hippocampus, hypothalamus; cerebellar-vestibular regions4. Neurotransmitters - GABA/Glutamate, Serotonin, Dopamine, Acetycholine, Epinephrine, Norepipheprine5. Hormones - HPA Axis (adrenals), Thyroid, Androgens, Estrogens, and most importantly Cortisol 6. Blood-Brain-Barrier - protector of the brain - damaged by head traumas, glutathione depletion, histamine, gut inflammation and permeability (leaky gut)7. Dysfunctional Pathways - Reactive Oxygen/Nitrogen Species (ROS/RNS), LPS, Mast Cell Activation, Kynurenine Pathway, Methylation, NO/ONOO, iNOS, excitotoxins (MSG, red 40), EMF radiation8. Nervous System Balance - Sympathetic/Parasympathetic balance - "fight or flight" vs. "rest and digest"9. Mitophagy/Autophagy - the clearing of "junk" from the brain10. Autoimmunity! - Self-tissue antibodies against things like GAD-65, cerebellum, thyroid, Myelin Basic Protein, Synapsin, Asiologanglioside, etcThese are 10 heavy topics!! But they are all important. You don't need to know everything about them, but knowing a little bit about each topic can help you figure out a bit more what's going on in your brain!
Neuropsychologist Dr. Skip hrin and Neurofeedback Legend Jay Gunkelman discuss: Listener Questions Head Trauma Bipolar/Schizophrenia Link between Mental Health and Heart health Blood Brain Barrier This show sponsored by: 6 TH ANNUAL SUPER BRAIN SUMMIT Friday, April 8, 2022 Live from the Peplow Pavilion, Hayden-Clark Alumni Center, Bradley University bradley.edu/superbrainsummit NeuroTraining Strategies eegstrategies.com/course-neuro "NeuroTraining Strategies offers a higher standard of EEG/qEEG education to EEG clinicians, technicians and neurofeedback practitioners with convenient, online BCIA and qEEG certified didactic courses." Have an idea for a topic or guest? pete@neuronoodle.com links used in the show: https://www.thencri.org/ https://www.upi.com/Health_News/2022/03/09/mental-illness-heart-disease-risk/3451646850380/ https://www.aapb.org/files/publications/biofeedback/2009/biof-37-03-108-111.pdf https://www.msn.com/en-us/tv/news/the-view-s-joy-behar-79-falls-off-chair-on-live-television-i-went-flying/ar-AAUBo5j https://www.bradley.edu/academic/cio/ccbr/symposiums/superbrainsummit/ https://www.practicalpainmanagement.com/pain/myofascial/research-insights-fibromyalgia-adhd-carry-misunderstood-links https://eegstrategies.com/course-neuro/ --- Send in a voice message: https://anchor.fm/neuronoodle/message Support this podcast: https://anchor.fm/neuronoodle/support
Thanks to modern medicine, we are living longer lives than ever before. But our longer lives have led to an increase in age-related degenerative illnesses like Alzheimer's disease, Parkinson's and ALS – neurological degenerative disorders that have proven very difficult to treat because of one of the strongest security systems in the human body: The Blood Brain Barrier. This episode looks at how an idea as old as the Trojan Horse could be used to finally break down that barrier for good.Featuring:Ryan Watts is the founder and CEO of Denali TherapeuticsMike Yee is Jefferies' managing director and senior biotech analystRachita Sumbria is an associate professor at the Chapman University School of Pharmacy
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