Podcasts about blood brain barrier

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Best podcasts about blood brain barrier

Latest podcast episodes about blood brain barrier

The Neuro Experience
Don't Take Omega-3s Until You Know This | Dr Nick Norwitz

The Neuro Experience

Play Episode Listen Later Jun 23, 2026 92:15


He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Dr. Nick Norwitz lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Dr. Nick Norwitz believes is coming in Alzheimer's gene therapy within the next decade. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The ApoE4 Paradox and the Case Report That Broke the Internet (00:00:57) Why Standard Omega-3 Supplements Fail and What to Take Instead (00:05:13) DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier (00:10:19) ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic (00:17:38) Why ApoE4 Carriers Burn Through DHA Faster and Need More (00:20:31) Women, Omega-3s, Menopause, and Brain Insulin Resistance (00:21:41) Statins, Sex Differences, and the DHA-Blood Sugar Connection (00:26:01) Statins and Dementia: What the Data Actually Say (00:32:24) Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology (00:42:19) The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance (00:45:21) Gene Editing, Prime Editing, and the Future of ApoE4 Therapy (00:49:33) Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data (00:55:10) The EZPAVE Trial: Why the Headlines Don't Hold Up (01:00:33) KetoneIQ: Ketones for Brain Energy and Focus (01:01:29) Cheers Health: Supporting Liver Function and Cognitive Recovery (01:03:54) If Not LDL, What Causes Heart Disease in Metabolically Healthy People? (01:12:05) The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism (01:19:10) Ketones, Women's Brains, and Clearing Misfolded Proteins (01:21:08) The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More (01:24:01) GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau (01:25:28) Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching (01:29:02) Why Nick Is Controversial And Why He Doesn't Mind _______ *Thank you to our sponsors*Fenix Health Science: fenixhealthscience.com Use code NEUROEXPPulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your orderFunction Health: https://www.functionhealth.com/louisanicolaBASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% offKetoneIQ: https://ketone.com/NEURO for 30% OFFCheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.instagram.com/louisanicola_/Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

The Goode Health Podcast
What Causes Brain Fog? The Blood-Brain Barrier, Brain Inflammation & Cognitive Decline

The Goode Health Podcast

Play Episode Listen Later Jun 15, 2026 24:12 Transcription Available


If you've been struggling with brain fog, fatigue, poor concentration, or memory issues and you've been told everything looks “normal,” this episode will help you understand what may actually be going on beneath the surface.We explore the emerging science behind the blood-brain barrier, a protective system that shields your brain from inflammation, toxins, and immune activity in the rest of the body. When this barrier is functioning well, your brain operates with clarity and stability. But when it becomes compromised, it may allow inflammatory signals, immune activity, and metabolic stress to affect cognitive function, potentially contributing to brain fog, fatigue, mood changes, and long-term cognitive decline.02:00 — Why the brain is different from the rest of the body06:10 — What is the blood-brain barrier? (Your brain's protection system)08:20 — The 3 main pathways to brain inflammation11:55 — A “leaky brain” barrier matters more than you think14:30 — What weakens the blood-brain barrier17:10 — Can the blood-brain barrier heal? 3 mechanisms of support21:20 — Gut health, gluten & molecular mimicry explainedRESOURCES: Grab all the links and resources mentioned in this episode at https://www.nicolegoodehealth.com/the-goode-health-podcast/episode-129DISCLAIMER: The content in this podcast and related website is not intended to be a substitute for medical advice. It is not intended to be used to diagnose or treat, instead it is designed to help educate and inspire. Always seek the advice of a professional medical practitioner or qualified health practitioner. Never ignore or disregard advice given to you based on information in this podcast or related website and do not delay in seeking medical advice.

HistoTalks: NSH Podcasts
Fixation on Histology: A New Approach to Visualizing Blood-Brain Barrier Penetration

HistoTalks: NSH Podcasts

Play Episode Listen Later Jun 11, 2026 4:18


Fixation on Histology: A New Approach to Visualizing Blood-Brain Barrier Penetration Written based on an article published in the Journal of Histotechnology To read the full article, click here. 

The Real Truth About Health Free 17 Day Live Online Conference Podcast
Flavonoids Support Antioxidant Enzymes in the Brain

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Play Episode Listen Later May 24, 2026 12:35


Flavonoids Support Antioxidant Enzymes in the Brain; Berry Compounds Cross Blood-Brain Barrier; Anthocyanin-Rich Berries Rescue Dopamine Cells; Peppers and Nicotine Receptors in Parkinson's; Ashwagandha for Gait and Brain Protection; Licorice Root Reduces Tremors and Sweetens Tea; Ginkgo Biloba Restores Dopamine and Protects Brain; Lowering Homocysteine with B12 and Folate #Parkinsons #BrainHealth #NeuroNutrition #HealthTalks

Heal Thy Self with Dr. G
If You Are 40 and Not Taking Creatine You Are Already Behind — Here Is Why | Heal Thy Self w/ Dr. G #486

Heal Thy Self with Dr. G

Play Episode Listen Later May 21, 2026 14:15


→ Get My Brand Masterlist: ⁠https://drchristiangonzalez.com/best-brands-form-2-2/⁠ → Shop all my verified, tested and preferred wellness products - includes most up to date brands: https://theswellscore.com/pages/drg Episode Description If you are a man over 40 and you are not taking creatine, you are aging with one hand behind your back. Between 40 and 60, men lose 3 to 8% of their muscle mass per decade. After 60, that rate accelerates. Brain creatine levels decline with age. Bone density goes down. And the body's ability to synthesize creatine on its own decreases too. Meanwhile, creatine remains one of the most researched, most affordable, and safest supplements in existence and most men over 40 either aren't taking it or are taking it wrong. Dr. G breaks down exactly what the research says, what dose actually works for your brain versus your muscles, and what to look for before you buy. In this episode, you'll learn:  • Why 5 grams a day saturates your muscles but does almost nothing for your brain, and what the emerging research says about the dose you actually need for cognitive protection, focus, and sleep deprivation recovery  • How creatine supports bone mineral density, mitochondrial stability, and antioxidant defense at the cellular level, not just muscle size  • Exactly what form to buy, what certifications to look for, and what to avoid when creatine shopping in 2026 This one is for every man over 40. And for every woman who has one in her life. Timestamps: 0:00 - Intro 1:19 - What Creatine Actually Is and Why Your Body Makes Less of It as You Age  2:37 - The Muscle Loss Reality After 40 (And Why It Accelerates After 60)  3:13 - What the Research Actually Shows on Creatine and Older Men  5:15 - The Dose Most Men Take Is Only Working for Their Muscles — Not Their Brain  5:52 - Why the Brain Needs Higher Doses to Cross the Blood-Brain Barrier  6:31 - The 2024 Sleep Deprivation Study That Changed How Dr. G Thinks About Dosing  8:02 - What the Research Shows on Creatine and Cognitive Health in Men Over 60  9:42 - How to Buy Creatine: The Right Form, the Right Dose, the Right Certifications  12:14 - Final Word: Why Creatine Is Now a Longevity Supplement, Not a Gym Supplement Learn more about your ad choices. Visit megaphone.fm/adchoices

Brave Bold Brilliant Podcast
Mark Stewart's Race Against Dementia Using Formula 1 Focus

Brave Bold Brilliant Podcast

Play Episode Listen Later May 12, 2026 54:44


In this moving episode Mark Stewart, film producer and chair of Race Against Dementia joins the show to discuss the personal and professional mission behind the charity founded by his father, F1 legend Sir Jackie Stewart.  Mark shares the heart-wrenching reality of his mother Helen's battle with frontotemporal dementia and how the family is applying the high-speed, problem-solving mindset of Formula 1 to accelerate the search for a cure.  From funding global research fellowships to utilising AI and predictive technologies, Mark provides an insightful look at how they are poking holes in a disease that affects one in three people born today. You'll Learn Why: The charity utilises the "Formula 1 mindset" of constant evolution and rapid problem-solving to fast-track medical breakthroughs that traditionally take decades. Race Against Dementia currently funds over 90 projects and fellowships worldwide, encouraging young researchers to take risks and utilise cross-industry technologies. The emotional toll of the disease has been hard on his family, emphasising the importance of meeting patients "where they are" and maintaining a sense of humour. Collaborating with teams like McLaren, the charity has used predictive technology to speed up laboratory processes, such as Petri dish testing, by up to eight times. This episode is living proof that no matter where you're starting from — or what life throws at you — it's never too late to be brave, bold, and unlock your inner brilliant. Visit ⁠https://brave-bold-brilliant.com/⁠ for free tools, guides and resources to help you take action now

Sparking Wholeness
Episode 330: Why Meds Stop Working: Inflammation, Gut Health & Hidden Triggers with Dr. Jaquel Patterson

Sparking Wholeness

Play Episode Listen Later Mar 3, 2026 35:51


Host Erin Kerry interviews internationally recognized naturopathic physician and functional medicine leader Dr. Jaquel Patterson to unpack why anxiety, depression, and ADHD are skyrocketing…and why medications often stop working. Dr. Patterson explains the missing link between chronic inflammation, infections, gut health, and neuropsychiatric symptoms — especially in kids and teens. They discuss the labs your doctor may not be running, how to identify biological drivers of mental health struggles, and why functional medicine looks beyond “normal” ranges to find what's optimal. Key Topics: - Chronic inflammation and how it disrupts the blood-brain barrier, neurotransmitters, and medication effectiveness - The biological drivers behind rising rates of anxiety, depression, and ADHD - Why standard labs miss key issues — and the optimal ranges that matter (ferritin, cortisol, thyroid, CRP, IL-6, ESR, testosterone) - How infections, including strep, Lyme disease, and tick-borne co-infections impact behavior, mood, and cognition - Understanding PANS/PANDAS and sudden-onset OCD, anxiety, and tics in children - The role of gut health, antibiotic exposure, and microbiome repair in brain development - Nutritional supports for kids: amino acids, protein intake, lithium orotate, beef liver, and micronutrients - Mold and environmental toxicity: why symptoms often get misdiagnosed as psychiatric - When medications stop working — and the physical issues to rule out - Practical first steps: blood work, environmental assessments, and small habits for long-term healing Links: Website: http://fairfieldfamilyhealth.com Facebook:       https://www.facebook.com/drjaquel/ Instagram:       https://www.instagram.com/naturopathic.physician/

Intelligent Medicine
Nutritional Empowerment for Cognitive Health, Part 1

Intelligent Medicine

Play Episode Listen Later Mar 3, 2026 31:46


Nutritional Support for Brain Health: Lifestyle, Curcumin, Magnesium, and Key Nootropics: Nutrition educator/formulator Neil Levin from Protocol for Life Balance details nutritional support for brain health amid skepticism about “brain-boosting” supplements, citing a preprint randomized controlled trial using a multifaceted lifestyle plan (diet, exercise, sleep) plus targeted supplementation that reportedly improved and even reversed symptoms in people with mild cognitive impairment. They contrast lifestyle strategies with costly, side-effect-prone injectable “plaque-buster” Alzheimer's drugs and notes debate about whether amyloid is a root cause or byproduct. The conversation highlights inflammation and oxidation as major aging-related brain threats and reviews supplements including a brain-targeted curcumin (discussing bioavailability, delivery methods, blood–brain barrier crossing, and claims of lowering beta-amyloid protein), magnesium L-threonate for CNS delivery, phosphatidylserine and acetylcholine support (including huperzine), ginkgo and gotu kola, glutamine/GABA pathways, creatine, omega-3s (DHA/EPA and algae sources), B vitamins, acetyl-L-carnitine, alpha-lipoic acid, and cocoa flavanols, plus concerns about supplement industry enforcement.

The Real Truth About Health Free 17 Day Live Online Conference Podcast
The Hidden Connection Between Phones and Brain Tumors

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Play Episode Listen Later Mar 2, 2026 50:59


See the evidence linking long-term cell phone use to glioblastoma and heart irregularities, especially in youth. Are our devices silently harming us? #CellPhoneRadiation #BrainHealth #EMFExposure

'Cuse Conversations
Studying the Blood-Brain Barrier to Devise Treatments for Alzheimer's and Parkinson's

'Cuse Conversations

Play Episode Listen Later Feb 16, 2026 34:57


The blood-brain barrier is a tightly locked network of cells that protects and defends the brain from harmful substances and pathogens that could cause damage. While this barrier serves to protect our brains, in the case of finding cures for Alzheimer's and Parkinson's, the blood-brain barrier has been a big obstacle.  Enter research from Shikha Nangia, the Milton and Anne Stevenson endowed professor of biomedical and chemical engineering and department chair in the College of Engineering and Computer Science. Working with undergraduate, graduate and post-doctoral students, the Nangia Research Lab uses theoretical and computational techniques to determine how to best enable the transport of drug molecules across the blood-brain barrier. Nangia's research led to the creation of the first molecular model depicting what the blood-brain barrier looks like, which has proven helpful in identifying what can and what cannot pass through the narrow tunnel into the brain.Understanding that Alzheimer's and cancer treatments are too large to pass through the blood-brain tunnel, Nangia's group is advancing research to find a cure for Alzheimer's and Parkinson's diseases. On this episode, Nangia will explain the findings of her research, share how students help advance this work, discuss how the Interactive Biomaterials Research Experiences for Undergraduates site on campus prepares participants for successful careers in science and engineering, and explores her role as a Syracuse University Art Museum faculty fellow.

Dissectible Me 5 minute anatomy
Blood brain barrier

Dissectible Me 5 minute anatomy

Play Episode Listen Later Feb 13, 2026 5:56


The blood brain barrier describes how the endothelial cells of the capillaries in the brain are tightly stuck together by tight junctions, wrapped in the feet of astrocytes and lined by a basement lamina. This stops most molecules from moving between the blood and the brain through any gaps. Instead, transporters are needed to transport molecules across the endothelial cells. Why does this happen in the brain? How does ethanol get to the brain? 

UNSW Centre for Ideas
Unpicking the Lock to the Blood-Brain Barrier with Dr Alexis Minchaca Acosta | One Big Idea

UNSW Centre for Ideas

Play Episode Listen Later Feb 12, 2026 21:23


The blood-brain barrier prevents 98% of medicines from reaching the brain. This prevents the effective treatment of neurological disorders, from cancer to Alzheimer’s. If we knew how to create drugs that could pass through this barrier, then we’d be able to create targeted, effective treatments. But doing so requires a lot of trial and error, and there aren’t a lot of effective, ethical, targeted treatments. Until now. Tune in to learn from Dr Alexis Minchaca Acosta, a Research Officer at the Children’s Cancer Institute, on how her work in lab-made blood brain barriers could change the game for neurological disorders.See omnystudio.com/listener for privacy information.

The Real Truth About Health Free 17 Day Live Online Conference Podcast
The truth about wireless radiation and your body

The Real Truth About Health Free 17 Day Live Online Conference Podcast

Play Episode Listen Later Feb 10, 2026 53:49


Wireless tech wasn't tested for long-term safety. Learn how EMFs disrupt your biology and why “non-ionizing” doesn't mean harmless. #EMFHealth #WirelessRisks #CellRadiation #HealthTalks

The xMonks Drive
Neurologist Dr. Vinit Banga: Pollution Is Damaging Your Brain (Stress, Sleep & Stroke Warning Signs)

The xMonks Drive

Play Episode Listen Later Feb 4, 2026 64:18


Neurologist Dr. Vinit Banga explains stress, sleep, stroke symptoms, brain health, and the effects of pollution on the brain in this powerful podcast episode with Gaurav Arora.This episode covers:•Stress symptoms and how chronic stress damages the brain•Deep sleep and why sleep is essential for brain repair•Stroke warning signs (FAST symptoms) and why minutes matter•Brain fog, memory loss, cognitive decline, early dementia signs•Delhi pollution / AQI effects on brain ageing and intelligence•Migraine triggers, headaches, and dangerous neurological red flags•Doctor-patient trust, Practo ratings, healthcare commercialization in India00:00 Impact of Delhi's Pollution on Brain Health00:37 Stress and Its Effects on Health01:39 Air Quality and Brain Aging03:24 Blood-Brain Barrier and Pollution06:03 Memory Issues and Aging07:04 Understanding Memory Formation12:20 Sleep Disorders and Brain Health13:35 The Importance of Deep Sleep16:09 Stress: The Silent Disruptor46:38 Doctor-Patient Trust and Ethical Concerns55:14 Commercialization in Healthcare01:04:15 Concluding Thoughts and GratitudeDr. Vinit Banga is Director & Head of Neurology & Neurovascular Intervention at Fortis Escorts, and shares life-saving insights on preventing stroke, protecting brain function, and understanding modern neurological risk factors.Keywords: neurologist podcast, brain health India, stress and stroke, sleep and brain, stroke symptoms, stroke warning signs, Delhi pollution brain damage, brain fog, dementia signs, migraine, Fortis neurologist, Dr Vinit Banga, Gaurav Arora podcast.#Stress #Stroke #BrainHealth #Sleep #Neurology #Podcast #DrVinitBanga

Alcohol-Free Lifestyle
The Brain's Security Guard: How to Repair Your Blood-Brain Barrier After Alcohol With Coach Matt

Alcohol-Free Lifestyle

Play Episode Listen Later Jan 7, 2026 16:35


Think your brain is protected from everything you ingest? Coach Matt reveals the truth about the blood-brain barrier, your brain's fortress that alcohol easily infiltrates because it is fat-soluble . Discover how chronic drinking weakens this barrier, leading to inflammation and that persistent "brain fog" .  This episode provides a hopeful recovery roadmap, explaining how the barrier begins to repair itself in just 90 days, with full restoration possible within two years . Learn the four lifestyle pillars, nutrition, exercise, hydration, and rest, that act as the repair crew to rebuild your brain's security system and reclaim your mental clarity .   Download my FREE guide: The Alcohol Freedom Formula For Over 30s Entrepreneurs & High Performers: https://social.alcoholfreelifestyle.com/podcast ★ - Learn more about Project 90: www.alcoholfreelifestyle.com/Project90 ★ - (Accountability & Support) Speak verbally to a certified Alcohol-Free Lifestyle coach to see if, or how, we could support you having a better relationship with alcohol: https://www.alcoholfreelifestyle.com/schedule ★ - The wait is over – My new book "CLEAR" is now available. Get your copy here: https://www.alcoholfreelifestyle.com/clear

Intelligent Medicine
Q&A with Leyla, Part 2: Diabetes Meds and Erectile Disfunction

Intelligent Medicine

Play Episode Listen Later Dec 11, 2025 39:04


What are your thoughts on the benefits of magnesium threonate?Is creatine helpful in building bone strength in osteoporosis?What are your thoughts on the REMS ultrasound to diagnose bone mineral density status?What should I do about my PSA, which appears to be trending upward?  Are my diabetes meds causing erectile dysfunction?Does maltodextrin spike blood glucose tremendously?

Medical Industry Feature
New Trial Device Opens Blood-Brain Barrier to Treat Glioblastoma

Medical Industry Feature

Play Episode Listen Later Nov 19, 2025


Guest: Brian Gill, M.D. Brian Gill, M.D., a neurosurgeon at NewYork-Presbyterian and Columbia, talks about a new clinical trial evaluating a device that can temporarily open the blood-brain barrier (BBB) to more effectively treat glioblastoma. Dr. Gill explains how this new sonication device uses focused ultrasound to temporarily disrupt the BBB in order to administer chemotherapy directly into the tumor bed. The trial is building on promising results from phase 1 and phase 2 trials, which demonstrated safety, efficacy, and the potential to enhance quality of life for patients with recurrent glioblastoma. © 2025 NewYork-Presbyterian

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The Stem Cell Report with Martin Pera
Crossing the Border: Modeling the Blood Brain Barrier

The Stem Cell Report with Martin Pera

Play Episode Listen Later Oct 23, 2025 29:52


The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human stem-cell-based models using brain endothelial cells are a powerful tool to investigate how disease-related conditions might affect the blood-brain barrier integrity. However, the cell type composition is critical to faithfully model transcytosis across the blood-brain barrier. Our guests today developed a blood-brain model using induced pluripotent stem cells (iPSCs)-derived endothelial cells with brain-specific identity. Using this model they were able to investigate how disease risk factors affect intracellular transport and reveal a new role for ApoE4 in the regulation of iron metabolism at the blood-brain barrier. GuestsRoberto Villaseñor, Principal Scientist and Laboratory Head of the Brain Delivery, Neuroscience and Rare Diseases at the Roche Innovation Center in Basel, Switzerland Martina Pigoni, Senior Discovery Scientist at Roche Innovation Center in Basel, Switzerland HostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationSupporting ContentApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells, Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific DirectorHunter Reed, Senior Marketing Coordinator

The Experience Miraclesâ„¢ Podcast
144. Q&A: Leucovorin, Autism, FRAT Tests, and More — Answers for Parents

The Experience Miraclesâ„¢ Podcast

Play Episode Listen Later Oct 3, 2025 60:41


In this episode, Dr. Tony Ebel breaks down the science behind folinic acid (Leucovorin), FRAT testing, and cerebral folate deficiency. But he also explains why focusing only on medications, gut health, and inflammation often leaves families stuck. Instead, Dr. Tony shows how the nervous system plays the central role in language, behavior, feeding, sleep, and overall healing—and why addressing it first changes everything. If your child has autism, language delays, or you've been told “it's all about the gut,” this episode will give you a new, root-cause perspective and a clearer path forward.Key Topics & Timestamps([00:03:00]) - Why the Medical World Only Sees the Nervous System Through Chemistry([00:11:00]) - What is Leucovorin? Understanding Folate Signaling & the Blood-Brain Barrier([00:18:00]) - This is NOT an Autism Cure: Why Targeted Therapy Only Works for Some Kids([00:23:00]) - The Research Results: How Folinic Acid Improved Verbal Communication([00:29:00]) - Leaky Gut, Auto-Antibodies & Brain Inflammation: The Autoimmune Connection([00:39:00]) - Toxins Aren't New, But Autism is Exploding: What Really Changed?([00:41:00]) - Low Vagal Tone & Sympathetic Dominance: The Hidden Gut Defense Failure([00:47:00]) - The Real Sequence: Neurology Before Gut, Before Inflammation, Before Everything([00:52:00]) - The Answer is "And": Why You Need Both Functional Medicine AND Nervous System Work([00:55:00]) - Where Healing Actually Starts: The Perfect Storm & Subluxation([00:57:00]) - The Right Order: Why the Sequence of Healing Changes Everything-- Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!

Combinate Podcast - Med Device and Pharma
208 - How Drugs Are Designed, Targets, Phenotypes, and Structure Based Design

Combinate Podcast - Med Device and Pharma

Play Episode Listen Later Oct 1, 2025 28:43


In this episode, Jesse Gordon-Blake, PhD, delves into the intricacies of medicinal chemistry, particularly focusing on drug discovery for ALS (amyotrophic lateral sclerosis). Jesse explains the process of discovering molecules that modulate biological pathways, the difference between structure-based and phenotype-based drug design, and the role computational methods play in drug development. The conversation also explores the challenges of crossing the blood-brain barrier, the importance of validating target response, and the complexities of progressing from a theoretical compound to preclinical studies. Additionally, Jesse touches on the significance of target product profiles, CNS drug design characteristics, and the iterative nature of medicinal chemistry. He concludes by discussing his current projects at Cortex, including fundraising strategies and timelines for drug development.00:00 Introduction to Medicinal Chemistry00:37 Drug Discovery Approaches02:01 Computational Methods in Medicinal Chemistry03:21 Challenges in ALS Drug Discovery04:23 Blood-Brain Barrier and Drug Design05:29 Key Properties for CNS Drug Design08:58 Day-to-Day in Drug Discovery09:45 Early Stage Drug Development12:28 Validating Drug Targets16:15 From Theory to Animal Testing22:46 Funding and Timeline Considerations25:45 Regulatory and Manufacturing Considerations28:32 Conclusion and Contact InformationDr. Jesse Gordon-Blake is an independent biotechnology and drug discovery consultant with expertise in medicinal chemistry and neurotherapeutics. He has led efforts in small molecule and peptide therapeutic development, AI-enabled drug discovery, and biotech startup formation, and currently serves as the CSO of Cortexa Therapeutics. He earned his PhD in Medicinal Chemistry from the University of Illinois at Chicago, focusing on developing innovative small-molecule enzyme modulators for Alzheimer's disease.https://www.linkedin.com/in/jesse-gordon-blake-phd-52a26274/https://www.cortexatherapeutics.com/Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

Proven Health Alternatives
Beating the Coverage: Defying Limits, On and Off the Field

Proven Health Alternatives

Play Episode Listen Later Jul 31, 2025 30:38


In this powerful episode, I sit down with someone who truly embodies grit, discipline, and the underdog advantage. From catching passes alongside Joe Montana to lining up against legends like Deion Sanders, JJ Birden's journey isn't just about athleticism—it's about mindset. What stood out most to me is how JJ turned obstacles into stepping stones. Despite being overlooked early on, he made it to the NFL through sheer determination and a no-excuses mentality. His stories from the field are more than just entertaining—they're lessons in perseverance, strategic thinking, and personal accountability. But his journey didn't stop when he left the game. JJ shares how he applied the same principles to entrepreneurship, launching his brand Beat the Coverage—a six-step framework for recognizing opportunity and winning in life. He breaks it all down in this episode, along with the health and wellness habits that keep him sharp and performing at his best today. This isn't just a highlight reel—it's a masterclass in resilience. If you've ever felt like the odds were stacked against you, this conversation is your playbook for rising above it. Key Takeaways: Resilience & Mindset: JJ Birden emphasizes the power of resilience and a strong mindset in overcoming barriers and achieving goals against the odds. Transition from Sports to Entrepreneurship: Birden discusses his career shift, leveraging his football experiences to motivate and guide others in their personal and professional journeys. "Beat the Coverage" Framework: JJ introduces a six-step framework designed to spot and exploit opportunities in life's challenges, aligning with his personal narrative. Health and Wellness Commitment: Maintaining a healthy lifestyle is crucial to Birden, who shares practical tips and routines that contribute to his well-being at age sixty. Family First: Birden and his wife made a significant impact on their family by adopting his five nieces and nephews, expanding their household from five to ten, showing immense dedication and love. More About JJ Birden: Born June 16, 1965, in Portland, Oregon, JJ's athletic prowess earned him a track scholarship to the University of Oregon. He walked on to the football team and later excelled in both football and track & field In the 1988 NFL Draft, JJ was selected in the 8th round by the Cleveland Browns and went on to play nine seasons as a wide receiver, surpassing the average NFL career length of under two years Despite standing just 5'10" and weighing 157 lbs, he defied the odds, overcoming injuries and even being turned down by four teams in five days to establish himself as a key player with the Browns, Chiefs, Falcons, and a stint with the Cowboys After retiring, JJ didn't slow down. He became a successful entrepreneur in the health and wellness space, distributing Isagenix products and building multiple ventures. He also spent years preparing for life after football, serving as a track coach, raising funds, investing, and coaching youth, then launched a career as a motivational speaker and performance coach JJ's signature speak­ing style blends stories from his NFL experience, playing two seasons with Hall‑of‑Famer Joe Montana, with clear, actionable strategies designed to help audiences in business and life "seize their opportunities" bestselling book, When Opportunity Knocks: 8 Surefire Ways to Take Advantage!, captures the principles he lives by, and teaches others to follow He and his college sweetheart, Raina, have been married over 35 years and live in the Phoenix area, raising three children and five nieces and nephews under their roof. Through his speaking, coaching, and writing, JJ inspires people everywhere to embrace their underdog spirit, push past limitations, and take bold steps toward their full potential. Website Instagram Facebook Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more! For over 50 years, NutriDyn has been a leader in functional nutrition, supporting healthcare practitioners with science-based supplements and unparalleled education. Since 1973, they've pioneered practitioner-exclusive formulas backed by rigorous testing and built on the latest research—delivering quality and peace of mind in every bottle. NutriDyn is more than just a supplement provider. They're committed to empowering practitioners through world-class educational resources, including national conferences, workshops, and seminars led by industry thought leaders. From clinical support to dedicated sales reps, NutriDyn offers an integrated approach to help elevate your practice and patient outcomes. Trusted. Transparent. Practitioner-focused. Join NutriDyn's wellness community and discover functional nutrition tailored for you—create your account today to take the first step toward better health: https://nutridyn.com/mprofile

bindwaves
The Blood Brain Barrier Conundrum

bindwaves

Play Episode Listen Later Jul 31, 2025 27:06 Transcription Available


Until only recently, treating Glioblastoma brain cancer with chemotherapy has not been achievable due to the blood brain barrier.  In today's Bindwaves episode, Dr. Michael Canney walks us through how Carthera developed a revolutionary method to deliver therapeutics to the brain utilizing an ultrasound system.  It is well known that the survival rate for Glioblastoma is 1 to 2 years.  Surgery tends to be the primary means to combat this horrible disease.  To improve these odds, an ultrasound implant is placed in the brain after the surgeon removes the tumor.  This implant, or mesh, contains an ultrasound transducer, which when activated during chemo treatments, disrupts the blood brain barrier thus allowing therapeutics to attach to the cancer cells.   Join us as Dr. Canney eloquently discusses the history of this treatment, Phase 1 and Phase 2 results, and their hopes for the Phase 3 trial. Support the showNew episodes drop every other Thursday everywhere you listen to podcasts.

Proven Health Alternatives
The Dangers of Untreated Concussions

Proven Health Alternatives

Play Episode Listen Later Jul 24, 2025 61:52


In this episode, I had the privilege of sitting down with Dr. Titus Chiu, a holistic concussion expert, to explore the intricacies of concussion and post-concussion syndrome. Dr. Chiu shared his personal journey that inspired him to specialize in brain health and develop innovative, natural approaches that go beyond conventional medicine. We discussed what really happens to the brain after a concussion, why every case is unique — like a fingerprint — and why the outdated “one-size-fits-all” approach so often fails. Dr. Chiu highlighted the critical importance of the blood-brain barrier, the autonomic nervous system, and the need to address the physical, chemical, and emotional pillars of brain health for lasting recovery. This conversation reinforced my belief that recovery is always possible with the right diagnosis and a multimodal treatment strategy. If you or someone you know is struggling with lingering brain symptoms, you'll find actionable insights — and real hope — in this episode. Key Takeaways: Concussions can vary greatly and do not always result in loss of consciousness, emphasizing the need for awareness around different symptoms and personalized treatment. A holistic approach involving the physical, chemical, and emotional pillars is crucial in diagnosing and treating post-concussion syndrome effectively. Blood-brain barrier health is essential to prevent ongoing brain inflammation, which can lead to more severe conditions if left untreated. Nutritional interventions, including omega-3 fatty acids and polyphenols, alongside specific supplements, can significantly aid in concussion recovery. The complexity of concussions requires a thoughtful, informed approach using advanced diagnostic tools and interventions for optimal recovery outcomes. More About Dr. Titus Chiu:Dr. Titus Chiu is a two-time #1 bestselling author, award-winning international speaker, and holistic brain expert that specializes in healing concussions, naturally. Dr. Chiu has a passion for empowering health-conscious people with the knowledge, insights, and practical actions needed to heal their brains and reclaim their lives after concussion– through advanced brain testing, state-of-the-art treatment technologies, and his clinically-proven concussion recovery programs. Dr. Chiu is the author of BrainSAVE! and Leaky Brain Fix. He works with patients and private clients from all over the world, both online and in-person at his holistic brain centers in California.   Website PrimexWeightLoss Instagram Facebook Connect with me! Website Instagram Facebook YouTube This podcast episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! For over 50 years, NutriDyn has been a leader in functional nutrition, supporting healthcare practitioners with science-based supplements and unparalleled education. Since 1973, they've pioneered practitioner-exclusive formulas backed by rigorous testing and built on the latest research—delivering quality and peace of mind in every bottle. NutriDyn is more than just a supplement provider. They're committed to empowering practitioners through world-class educational resources, including national conferences, workshops, and seminars led by industry thought leaders. From clinical support to dedicated sales reps, NutriDyn offers an integrated approach to help elevate your practice and patient outcomes. Trusted. Transparent. Practitioner-focused. Join NutriDyn's wellness community and discover functional nutrition tailored for you—create your account today to take the first step toward better health: https://nutridyn.com/mprofile

Empowered Patient Podcast
Developing Chemically Modified Drugs that Cross the Blood-Brain Barrier to Treat Glioblastoma with Dr. Sandra Silberman CNS Pharmaceuticals

Empowered Patient Podcast

Play Episode Listen Later Jul 21, 2025 23:45


Dr. Sandra Silberman, Chief Medical Officer at CNS Pharmaceuticals, has developed new therapies for glioblastoma that can cross the blood-brain barrier to reach brain tumors. Their lead drug candidates have been modified to slip into the membranes to inhibit tumor growth and attack the cancer cells. The anthracycline-based and taxane-based drugs are showing efficacy in clinical trials and are not showing the cardiotoxicity associated with anthracyclines. Sandra explains, "Anthracyclines are characteristically cardiotoxic. And we have just conducted a study of over 160 patients who have received this, and some of them for quite a long period of time. And we have not seen any cardiotoxicity. So we have one of the anthracyclines that is the first to actually cross the blood-brain barrier without any help from other mechanisms, and it also doesn't cause cardiotoxicity. So we have a really open field to be able to further develop this drug. And we know that this drug, based on all of our preclinical studies, is very effective against glioma cells." "This is to the great credit of the chemists that we've been working with. Can I develop a compound that can not be a substrate for this, so it can't even bind to this efflux transporter and can slip by? But not only that, can it be lipophilic, meaning it can get through all those membranes, and it can be something that leaks into the brain itself. So the two molecules that we have are not substrates for these multidrug-resistant transporters. They're also very highly lipophilic, meaning they're very oily. And so I guess this has two meanings to it, but they're oily and then they slip into the brain and are able to do what they're supposed to be doing, which is the inhibition of tumor growth and killing the tumor cells." #CNSPharma #Glioblastoma ##BrainCancer #BloodBrainBarrier #NeuroOncology #CancerResearch #DrugDevelopment #BrainTumor cnspharma.com  Download the transcript here

Empowered Patient Podcast
Developing Chemically Modified Drugs that Cross the Blood-Brain Barrier to Treat Glioblastoma with Dr. Sandra Silberman CNS Pharmaceuticals TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Jul 21, 2025


Dr. Sandra Silberman, Chief Medical Officer at CNS Pharmaceuticals, has developed new therapies for glioblastoma that can cross the blood-brain barrier to reach brain tumors. Their lead drug candidates have been modified to slip into the membranes to inhibit tumor growth and attack the cancer cells. The anthracycline-based and taxane-based drugs are showing efficacy in clinical trials and are not showing the cardiotoxicity associated with anthracyclines. Sandra explains, "Anthracyclines are characteristically cardiotoxic. And we have just conducted a study of over 160 patients who have received this, and some of them for quite a long period of time. And we have not seen any cardiotoxicity. So we have one of the anthracyclines that is the first to actually cross the blood-brain barrier without any help from other mechanisms, and it also doesn't cause cardiotoxicity. So we have a really open field to be able to further develop this drug. And we know that this drug, based on all of our preclinical studies, is very effective against glioma cells." "This is to the great credit of the chemists that we've been working with. Can I develop a compound that can not be a substrate for this, so it can't even bind to this efflux transporter and can slip by? But not only that, can it be lipophilic, meaning it can get through all those membranes, and it can be something that leaks into the brain itself. So the two molecules that we have are not substrates for these multidrug-resistant transporters. They're also very highly lipophilic, meaning they're very oily. And so I guess this has two meanings to it, but they're oily and then they slip into the brain and are able to do what they're supposed to be doing, which is the inhibition of tumor growth and killing the tumor cells." #CNSPharma #Glioblastoma ##BrainCancer #BloodBrainBarrier #NeuroOncology #CancerResearch #DrugDevelopment #BrainTumor cnspharma.com Listen to the podcast here  

The Vibrant Wellness Podcast
Healing the Blood-Brain Barrier for Lasting Brain Vitality with Dr David Musnick

The Vibrant Wellness Podcast

Play Episode Listen Later Jul 2, 2025 42:36


Could your “brain fog” actually be a sign of neuroinflammation or a leaky blood-brain barrier? What if the key to lifelong cognitive resilience lies in healing the brain, not just resting it, after a concussion? Today, we unveil the latest clinical insights into brain health, concussion recovery, and the vital role of the blood-brain barrier in cognitive longevity. Join Dr. Emmie Brown, ND, and Melissa Gentile, INHC, welcoming Dr. David Musnik, a board-certified sports and functional medicine expert with 25+ years in brain injury management. Dr. Musnik discusses his integrative, pathophysiology-based concussion treatment method, a shift from conventional approaches that overlook underlying biological processes.They discuss the blood-brain barrier, its structure, and its crucial role as the brain's gatekeeper. The effects of increased permeability, or a “leaky brain,” are examined, as it allows toxins, pathogens, and biotoxins (like mold and metals) to interfere with neural function. Dr. Musnik explains how neural inflammation, mitochondrial issues, and autoimmunity lead to cognitive decline, brain fog, and symptoms similar to neurodegenerative diseases. He also highlights interventions such as frequency-specific microcurrent therapy, anti-inflammatory nutraceuticals, dietary changes, avoiding electromagnetic fields, and using tools like the NeuroZoomer Plus test.Key Takeaways from Today's Episode:

Michael and Mom Talk Cancer
Michael and Mom Talk Glioblastoma Clinical Trial: Episode 63, Using Ultrasound to Break the Blood Brain Barrier

Michael and Mom Talk Cancer

Play Episode Listen Later Jun 30, 2025 41:45


Join Michael and mom Ashlee as they talk to Michael Canney, Ph.D., who is leading an exciting Phase 3 clinical trial that holds the promise of reshaping brain cancer treatment in particular in glioblastoma. This trial is testing a new surgical implant using ultrasound to enhance chemotherapy effectiveness against brain tumors, in particular because of the blood/brain barrier. Mike is at the forefront of efforts at 40 clinical sites worldwide, 20 in the US, working to push the boundaries in brain cancer treatments. The conversation takes a personal turn, as always with Michael and mom :)find out more about this phase 3 clinical trial for Glioblastoma:https://sonobird.eu/More info about Carthera:https://carthera.eu/More about Michael Canney on Linked In:https://www.linkedin.com/in/michael-canney-ph-d-42457b5/

The Impulsive Thinker
Behind the ADHD Blood-Brain Barrier: Surprising Truths for Entrepreneurs

The Impulsive Thinker

Play Episode Listen Later Jun 16, 2025 31:43


André, The Impulsive Thinker™, sits down with renowned adult ADHD psychiatrist Dr. William Dodson to tackle the confusing process of ADHD medication management for Entrepreneurs. Together, they break down why finding the right medication and dose is far from one-size-fits-all. Dr. Dodson reveals why targeting specific symptoms, understanding the blood-brain barrier, and personalized titration matter more than body weight or standard protocols. Discover what ADHD meds can—and cannot—actually do, how to think about “target symptoms,” and why collaboration with your prescriber matters. If you're an ADHD Entrepreneur struggling to dial in your meds, this episode is a must-listen.  

Our Opinions Are Correct
Public Health Is a Utopian Vision (with Naseem Jamnia and Natasha O'Brown)

Our Opinions Are Correct

Play Episode Listen Later Jun 12, 2025 58:47


Public health is a vital part of keeping all of us safe — but what does it mean, and where did the concept come from? Special guest host Naseem Jamnia breaks it down for us, and tells us about some fantasy stories that show why public health is a collective concern. Plus we talk to scientist Natsaha O'Brown at Rutgers University about all the discoveries we've made lately about the blood-brain barrier.

Aging-US
Aging Increases Brain's Sensitivity to Hypoxia and Blood-Brain Barrier Damage in Mice

Aging-US

Play Episode Listen Later Jun 3, 2025 3:55


BUFFALO, NY — June 3, 2025 — A new #research paper was #published in Aging (Aging-US) on May 1, 2025, as the #cover of Volume 17, Issue 5, titled “Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age.” In this study, researchers Arjun Sapkota, Sebok K. Halder, and Richard Milner from San Diego Biomedical Research Institute investigated how aging affects the brain's vulnerability to low oxygen, or hypoxia. Using C57BL/6J mice ranging from 2 to 23 months of age, they identified specific oxygen levels that disrupt the blood-brain barrier (BBB)—a critical structure that protects brain tissue from harmful substances. The findings are important for understanding age-related cognitive decline and the potential risks faced by individuals with chronic oxygen-limiting conditions such as asthma, sleep apnea, emphysema, and heart disease. The BBB is essential for maintaining brain health. In this study, mild and prolonged hypoxia—called chronic mild hypoxia—was found to compromise the BBB in mice. Older mice showed significantly more BBB disruption than younger ones. Notably, barrier weakening and blood vessel changes occurred at oxygen levels of just 15% in aged mice, compared to 13% in young mice. These data suggest that the aging brain is more sensitive to oxygen deprivation, even at levels that may be considered only mildly hypoxic. The researchers also determined when this vulnerability emerged. The BBB showed increased sensitivity to low oxygen not only in aged mice but also in mice as young as 2 to 6 months, with a second spike occurring between 12 and 15 months—equivalent to middle age in mice. These findings may reflect age-dependent changes in brain vascular function and remodeling capacity. “Hypoxia-induced endothelial proliferation was relatively constant across the age range, but advanced age strongly enhanced the degree of BBB disruption (4-6-fold greater in 23 months vs. 2 months old).” Another key focus was microglial activation, a sign of brain inflammation. Aged mice exhibited higher microglial activation across all oxygen levels, including normal conditions. Chronic microglial activation is closely linked to neuroinflammation and has been implicated in diseases such as Alzheimer's. While the rate of blood vessel formation was constant across ages, the degree of BBB disruption increased sharply with age, suggesting that repair mechanisms may weaken over time. These results may help explain why older adults with chronic hypoxia-related diseases are at higher risk for neurodegeneration and cognitive decline. The study also draws attention to the risks of high-altitude exposure for aging populations, where oxygen levels naturally drop. Altogether, these findings underscore the importance of protecting brain health in older individuals by managing oxygen exposure and reducing hypoxia-related risks. The researchers emphasize the need to develop new therapies that support blood-brain barrier integrity, particularly in aging populations exposed to chronic or intermittent low-oxygen conditions. DOI - https://doi.org/10.18632/aging.206241 Corresponding author - Richard Milner - rmilner@sdbri.org Video short - https://www.youtube.com/watch?v=Nr6rTm7aJRo Keywords - aging, blood-brain barrier integrity, endothelial, proliferation, microglia, chronic mild hypoxia, hypoxic threshold To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Neurocareers: How to be successful in STEM?
Ultrasound Implant Against Glioblastoma: Disrupting the Blood-Brain Barrier with Michael Canney, PhD

Neurocareers: How to be successful in STEM?

Play Episode Listen Later May 25, 2025 58:48


What does it take to challenge the deadliest brain tumors with sound waves? How do you scale a medtech startup into a multinational clinical company? And what advice can a top neuro-oncology innovator offer to those hoping to follow a similar path? Welcome to Neurocareers: Doing the Impossible! — The podcast where we explore the extraordinary journeys of those advancing the future of neuroscience and neurotechnology. I'm your host, Dr. Milena Korostenskaja. Today we're speaking with Dr. Michael Canney, the Chief Scientific Officer at Carthera, a clinical-stage medtech company revolutionizing brain therapy through therapeutic ultrasound. With over 15 years of experience in MedTech innovation, Dr. Canney specializes in glioblastoma, neurodegenerative diseases, and therapeutic ultrasound drug delivery. He's currently leading the SONOBIRD Phase 3 clinical trial across 40 sites in the U.S. and Europe, pushing the boundaries of what's possible in treating recurrent glioblastoma. Michael's career spans everything from FDA regulatory strategy to high-impact academic collaborations. He's co-authored over 50 peer-reviewed papers in top-tier journals and 14 patent families. But what truly drives him is improving patient outcomes and bringing hope to some of the most challenging areas in brain health. Whether you're curious about clinical trials, neuro-oncology innovations, or carving out your own career in medtech, this conversation is packed with insight and inspiration. Let's dive in! Chapters: 00:00:01 - Revolutionizing Brain Therapy with Ultrasound, Introducing Dr. Michael Canney 00:04:49 - Advancements in Ultrasound for Drug Delivery 00:10:15 - Innovative Ultrasound for Drug Delivery 00:13:49 - Innovative Ultrasound Approach for Tumor Treatment 00:16:02 - Understanding Blood-Brain Barrier Disruption 00:19:28 - Device Overview and Design Features 00:21:32 - Ultrasound Technology for Tumor Treatment 00:24:15 - Device Implantation in Cancer Treatment 00:28:34 - Challenges in Glioblastoma Treatment Trials 00:31:46 - Dr. Michael Canney's Journey into Ultrasound Research 00:36:15 - Starting a Postdoc Journey 00:39:20 - Career Development in Neuroscience 00:43:31 - Building a Startup Team 00:47:38 - Hiring for Clinical Application Specialists 00:52:16 - Growth of Careers in Neurotechnology 00:54:26 - Using AI in Clinical Trials 00:57:13 - Challenges in Medical Device Approval 00:59:41 - Overcoming Challenges in Medical Innovations 01:02:20 - Clinical Trials and Company Information About the Podcast Guest: Michael Canney, Ph.D., is Chief Scientific Officer at Carthera, a clinical-stage medtech company advancing brain therapy through innovative ultrasound-based devices. A co-author of more than 50 peer-reviewed articles, he specializes in neuro-oncology, glioblastoma and neurodegenerative diseases. At Carthera, he is responsible for leading scientific collaborations with academic institutions, organizing U.S. clinical trials and more. Connect with Dr. Canney on LinkedIn: https://www.linkedin.com/in/michael-canney-ph-d-42457b5/ Learn more about Carthera: https://carthera.eu/ Get familiar with the Sonobird clinical trial: https://sonobird.eu/ About the Podcast Host: The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a career coach for people in neuroscience and neurotechnologies. As a professional coach with a background in neurotech and Brain-Computer Interfaces, Dr. K understands the unique challenges and opportunities job applicants face in this field and can provide personalized coaching and support to help you succeed. Here's what you'll get with one-on-one coaching sessions from Dr. K: Identification and pursuit of career goals Guidance on job search strategies, resume, and cover letter development Neurotech / neuroscience job interview preparation and practice Networking strategies to connect with professionals in the field of neuroscience and neurotechnologies Ongoing support and guidance to help you stay on track and achieve your goals You can always schedule a free neurocareer consultation/coaching session with Dr. K at https://neuroapproaches.as.me/free-neurocareer-consultation Subscribe to our Nerocareers Newsletter to stay on top of all our cool neurocareers news at updates https://www.neuroapproaches.org/neurocareers-news  

Soaring Child: Thriving with ADHD
156: Best Herbs for ADHD with Dana Kay

Soaring Child: Thriving with ADHD

Play Episode Listen Later May 1, 2025 16:45


Managing ADHD naturally can feel overwhelming, but what if there were powerful plant-based remedies that could help? In this episode of The Soaring Child Podcast, host Dana Kay explores the best herbs for ADHD, breaking down the science behind how they support focus, reduce stress, and regulate emotions. She covers research-backed benefits of herbs like Rhodiola Rosea, OPCs, ginkgo, and ginseng—offering practical strategies for incorporating them into your child's routine. Dana Kay, a leading ADHD health practitioner, has helped thousands of families find natural, effective solutions for ADHD symptoms. In this episode, she provides a clear, no-fluff guide to using herbs safely and effectively. Whether you're new to natural remedies or looking to refine your child's supplement plan, this episode is packed with actionable insights you won't want to miss! Make sure and grab your Herbs for ADHD Cheat Sheet at the link provided!  Links Mentioned in the Show:  Functional Lab Testing Video -  https://info.adhdthriveinstitute.com/lab-testing-for-adhd1  My Favorite Place to Buy Supplements - http://adhdthriveinstitute.com/supplements  My Favorite Herbs that are Mentioned in this Episode: Rhodiola Rosea - https://shop.adhdthriveinstitute.com/rhodiola-rosea.html  OPC - https://shop.adhdthriveinstitute.com/curcumasorb-mind-60-capsules.html  Ginkgo - https://amzn.to/4ij9EK1  Ginseng - https://amzn.to/4ihGDye  Herbs for ADHD Cheat Sheet - https://info.adhdthriveinstitute.com/supplement-for-adhd-herbs  Links to Previous Episodes in this Supplements for ADHD Series: Magnesium -  https://adhdthriveinstitute.com/podcast/soaring-child-episode-93/  Saffron - https://adhdthriveinstitute.com/podcast/soaring-child-episode-136/  GABA - https://adhdthriveinstitute.com/podcast/soaring-child-episode-137/  L-Theanine - https://adhdthriveinstitute.com/podcast/soaring-child-episode-142/  Bio Essentials - https://adhdthriveinstitute.com/podcast/soaring-child-episode-144/  Omegas - ​​ https://adhdthriveinstitute.com/podcast/soaring-child-episode-146/  Iron - https://adhdthriveinstitute.com/podcast/soaring-child-episode-148/  Vitamin D - https://adhdthriveinstitute.com/podcast/soaring-child-episode-150/  Zinc - https://adhdthriveinstitute.com/podcast/soaring-child-episode-152/  Zembrin -  https://adhdthriveinstitute.com/podcast/soaring-child-episode-154/  Key Takeaways: [3:04] Overview of Rhodiola Rosea and Its Benefits [3:49] Scientific Studies on Rhodiola for ADHD [4:23] How to Choose and Use Rhodiola Safely [8:45] Introduction to OPCs and Their Brain-Boosting Effects [9:14] The Role of OPCs in Strengthening the Blood-Brain Barrier [10:15] How OPCs Improve Cognitive Function and Focus [13:10] Ginkgo & Ginseng: Natural Stimulant Alternatives [14:15] Key Considerations Before Using Herbs for ADHD [14:52] Final Thoughts and Actionable Next Steps Memorable Moments: "Herbs are powerful plant-based remedies that could sharpen focus, reduce stress, and support emotional regulation—and most people completely overlook them." "Rhodiola is like a built-in stress shield for the brain. It helps calm that chaos, sharpen focus, and smooth out emotional roller coasters." "In just one week, people taking Rhodiola felt less stressed, more focused, and mentally sharper." "Rhodiola was compared to the antidepressant sertraline, also known as Zoloft. While sertraline had stronger effects, Rhodiola had fewer side effects and was better tolerated." "Research shows Rhodiola may enhance memory and learning by helping neurons in the brain communicate better." "OPCs are antioxidants found in blueberries, grapes, and dark chocolate, and they help protect the brain while strengthening the blood-brain barrier." "One study found that drinking blueberry juice, which is rich in OPC flavanols, for 12 weeks improved working memory, blood flow to the brain, and cognitive performance in adults." "Ginkgo and ginseng act like stimulants without the side effects, and studies show they may help improve attention and dopamine levels in kids with ADHD." "Herbs are powerful, even though they're natural. They can interact with medications, so always consult a professional." "There is no one-size-fits-all approach. Functional lab testing can help determine which nutrients and herbs your child actually needs." Dana Kay Resources:

From the Spectrum: Finding Superpowers with Autism
Dr. Richard Frye, MD, PhD: All about Leucovorin & Benefits for the Autistic Phenotype

From the Spectrum: Finding Superpowers with Autism

Play Episode Listen Later Mar 31, 2025 62:07 Transcription Available


For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr. Richard Frye https://drfryemdphd.comRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurological Health Foundation https://neurologicalhealth.orgHealthy Child Guide https://neurologicalhealth.org/the-guide-5/Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.co/?ref=autismuse "autism" for a 10% discount,0:00 Dr. Richard Frye0:58 Daylight Computer Company5:17 Chroma Light Devices8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)17:34 Cerebral Folate deficiency; BH4, Placenta & Womb23:35 Folate deficiency & Autism26:21 Clinical Studies & Data29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration42:53 Folate Autoantibodies & Maternal Health & Markers45:30 Studies & Behavioral outcomes; inflammation & thyroid findings46:58 Neural development; Language connections, white matter tracts & distal connections48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida51:08 Preparing for pregnancy53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness59:32 Guidance & SupportX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Empowered Patient Podcast
Intranasal Delivery of Cancer Drugs Bypasses the Blood-Brain Barrier with Dr. Thomas Chen NeOnc Technologies

Empowered Patient Podcast

Play Episode Listen Later Mar 10, 2025 21:58


Dr. Thomas Chen, Founder, CEO, and CSO of NeOnc Technologies, is working on the challenge of delivering drugs across the blood-brain barrier by using an intranasal delivery approach to target brain cancers. This delivery platform leverages the cranial nerve to transport the drugs directly to the brain, bypassing the blood-brain barrier. Genomic analysis of the long-surviving patients in the phase one trial revealed a common genetic mutation, informing the trial design for the next phase. Thomas explains, "So our platform is what we call intranasal delivery. And with the intranasal delivery, we're not trying to cross the blood-brain barrier. We're trying to cross over it. And how we're doing that is doing the delivery of the drug via what we call the C nerves. Now the cranial nerves are, we have 12 cranial nerves in our brain. These cranial nerves have various functions, but the cranial nerves involved with the nasal brain delivery are the first and the fifth cranial nerves. The first cranial nerve is what we call the olfactory nerve. That's the nerve that's responsible for smell. The fifth cranial nerve is called the trigeminal nerve, which involves facial sensation and allows us to chew."   "So what happens is that when we want to deliver the drug to the brain cancer, we have the patient inhale it. When the patient inhales, it goes through the nose, and through the olfactory nerve, it goes to the brain. Usually, that molecule then absorbs in the spinal brain and then circulates to the target, in this case, brain cancer. Now you know how powerful that cranial nerve is from the standpoint of what it does when you smell something, that scent, that odor gets transported from the olfactory nerve to our brain. And that's basically what we're doing. We're taking something external to the brain, allowing the cranial nerve to absorb and transport it to the brain." #NeOnc #BloodBrainBarrier #BBB #BrainCancer #DrugDelivery neonc.com Download the transcript here

Empowered Patient Podcast
Intranasal Delivery of Cancer Drugs Bypasses the Blood-Brain Barrier with Dr. Thomas Chen NeOnc Technologies TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Mar 10, 2025


Dr. Thomas Chen, Founder, CEO, and CSO of NeOnc Technologies, is working on the challenge of delivering drugs across the blood-brain barrier by using an intranasal delivery approach to target brain cancers. This delivery platform leverages the cranial nerve to transport the drugs directly to the brain, bypassing the blood-brain barrier. Genomic analysis of the long-surviving patients in the phase one trial revealed a common genetic mutation, informing the trial design for the next phase. Thomas explains, "So our platform is what we call intranasal delivery. And with the intranasal delivery, we're not trying to cross the blood-brain barrier. We're trying to cross over it. And how we're doing that is doing the delivery of the drug via what we call the C nerves. Now the cranial nerves are, we have 12 cranial nerves in our brain. These cranial nerves have various functions, but the cranial nerves involved with the nasal brain delivery are the first and the fifth cranial nerves. The first cranial nerve is what we call the olfactory nerve. That's the nerve that's responsible for smell. The fifth cranial nerve is called the trigeminal nerve, which involves facial sensation and allows us to chew."   "So what happens is that when we want to deliver the drug to the brain cancer, we have the patient inhale it. When the patient inhales, it goes through the nose, and through the olfactory nerve, it goes to the brain. Usually, that molecule then absorbs in the spinal brain and then circulates to the target, in this case, brain cancer. Now you know how powerful that cranial nerve is from the standpoint of what it does when you smell something, that scent, that odor gets transported from the olfactory nerve to our brain. And that's basically what we're doing. We're taking something external to the brain, allowing the cranial nerve to absorb and transport it to the brain." #NeOnc #BloodBrainBarrier #BBB #BrainCancer #DrugDelivery neonc.com Listen to the podcast here

The Experience Miraclesâ„¢ Podcast
83. You're Not Just Anxious—Your Gut Is Too

The Experience Miraclesâ„¢ Podcast

Play Episode Listen Later Mar 4, 2025 57:58


In this insightful episode of the Experience Miracles Podcast, Dr. Tony Ebel interviews Dr. Meg Mill, a functional medicine expert with a background in pharmacy who specializes in the gut-brain connection. They explore how the nervous system plays a crucial foundational role in gut health, anxiety, and overall wellness. Dr. Mill shares her personal health journey that led her to functional medicine and introduces her 3R Protocol (Regulate, Repair, Rewire) for addressing health challenges. The conversation highlights why traditional treatments often fail to address the interconnected nature of gut issues and mental health concerns, and offers practical insights for parents seeking drug-free solutions for their children's chronic health challenges.[00:00:00] Introduction & Dr. Meg's Personal JourneyDr. Meg's transition from pharmacy to functional medicinePersonal struggles with gut issues, anxiety, and sleep problems that conventional medicine couldn't solve[00:09:00] The Nervous System-First ApproachWhy prioritizing nervous system regulation before nutrition creates better outcomesThe typical patient journey: conventional medicine → nutritional approaches → nervous system regulationThe importance of breaking this cycle by addressing the foundation first[00:14:00] Sympathetic Dominance & Digestive HealthHow the autonomic nervous system affects digestionThe physiological cascade when we're stuck in "fight or flight"Why stress creates digestive issues even with a perfect diet[00:25:00] The Anxiety-Digestion LoopThe vagus nerve's role in gut-brain communicationHow gut dysbiosis leads to immune responses and brain inflammationClarification about serotonin in the gut (primarily for motility, not mood)[00:38:00] The Blood-Brain Barrier & Individualized CareConnection between gut permeability and blood-brain barrier integrityThe importance of personalized, whole-body approaches to healing[00:46:00] The 3R Protocol ExplainedRegulate: Bringing balance to physiological systemsRepair: Healing damaged barriers and tissuesRewire: Neuroplasticity, vagal nerve toning, and nervous system retraining[00:54:00] Resources & Closing ThoughtsDr. Meg's podcast: "A Little Bit Healthier"The value of addressing nervous system regulation as the foundation for all healingGet connected with Dr. Meg Millwebsite: megmill.com   instagram: @megmill-- Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!

Intelligent Medicine
Intelligent Medicine Radio for January 11, Part 2: Why 70 is the New 60

Intelligent Medicine

Play Episode Listen Later Jan 13, 2025 42:18


“Active holistic therapy” for prostate cancer with diet and fish oil helps defer need for surgery, hormone blockade, radiation; Why 70 is the new 60; Long-term harmful effects of acid-blockers; Do memory supplements pass the blood-brain barrier? Fish oil, krill oil, olive oil for cardiovascular prevention; Paxlovid aggressively promoted but overprescribed for otherwise healthy patients. 

Christian Natural Health
Restoring the Integrity of the Blood Brain Barrier

Christian Natural Health

Play Episode Listen Later Jan 3, 2025 7:58


Today's podcast comes from this blog post: Restoring the Integrity of the Blood Brain Barrier Christian Natural Health was ranked in the top 100 Christian Podcasts by Feedspot! https://blog.feedspot.com/christian_podcasts/ Discover more Christian podcasts at lifeaudio.com and inquire about advertising opportunities at lifeaudio.com/contact-us.

JJ Virgin Lifestyle Show
Brain Fog After 40? Fix Your Blood-Brain Barrier with Neurologist Dr. Titus Chiu and JJ Virgin

JJ Virgin Lifestyle Show

Play Episode Listen Later Jan 1, 2025 65:32


"After my car accident, I discovered that trauma wasn't the only cause of leaky brain - chronic stress, poor sleep, and inflammation can all compromise our brain's protective barrier. The good news? Just like leaky gut, leaky brain can be healed." - Dr. Titus Chiu In this eye-opening episode, I sit down with functional neurologist Dr. Titus Chiu to explore the fascinating concept of "leaky brain" and its profound impact on cognitive health, especially for women in midlife.  Dr. Chiu's personal journey from a devastating accident to becoming a leading expert in brain health offers hope and practical solutions for anyone experiencing brain fog, memory issues, or cognitive decline. His groundbreaking research reveals how the blood-brain barrier functions like a nightclub bouncer, carefully controlling what enters our most precious organ - and what happens when that security system breaks down. Whether you're navigating perimenopause, recovering from a concussion, or simply wanting to maintain sharp cognitive function, this episode delivers actionable strategies to protect and enhance your brain health. What you'll learn: The surprising connection between leaky gut and leaky brain, and why women in perimenopause may be particularly vulnerable How to recognize the warning signs of a compromised blood-brain barrier, from brain fog to unexplained cognitive fluctuations The 5 essential pillars of brain health, including specific foods that nourish your neurons Why social connections and regular movement (especially dancing!) are crucial for preventing cognitive decline Game-changing supplements that support brain health, including the unexpected benefits of creatine! Simple breathing techniques to instantly calm the nervous system and protect your brain The critical importance of morning sunlight for resetting your brain's daily rhythm   Full show notes: https://www.jjvirgin.com/brainsavequiz   Learn more about Dr. Titus Chiu: https://drtituschiu.com/  Flavorchef bone broth: https://affiliates.theflavorchef.com/121.html Vital Choice wild-caught seafood: https://vitalchoice.sjv.io/daKYGy Reignite Wellness™ Plant-Based & Paleo-Inspired All-In-One Shakes: https://reignitewellness.com/collections/shakes Download my FREE Best Rest Sleep Cheat Sheet: https://jjvirgin.com/sleep Sleep Mask: https://amzn.to/3vkiMuB The Virgin Diet: https://reignitewellness.com/products/the-virgin-diet-paperback Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products Try SHEatine: https://reignitewellness.com/collections/all/products/sheatine-capsules Episode Sponsors:  Try Timeline: https://www.timelinenutrition.com/shop?rfsn=7082975.4b75243 Use code JJ10 for 10% off all products Go to qualialife.com/VIRGINWELLNESS to try Qualia risk free for up to 100 days and code VIRGINWELLNESS for an additional 15% off Take Dr. Chiu's FREE Leaky Brain Quiz  

Mind & Matter
Neurosurgery, Blood-Brain Barrier, Ultrasound Technology for Brain Diseases & Disorders | Nir Lipsman | #181

Mind & Matter

Play Episode Listen Later Oct 15, 2024 64:17


Send us a textAbout the guest: Nir Lipsman, MD, PhD is a neurosurgeon and neuroscientist at the University of Toronto.Episode summary: Nick and Dr. Lipsman discuss: neurosurgery; the blood-brain barrier and how it works; using focused ultrasound technology to non-invasively treat patients; regulatory impediments to clinical research; costs, constraints, and future applications of ultrasound tech for treating psychiatric conditions; and more.Related episodes:M&M #168: Sleep: Neural Circuits, Orexin/Hypocretin, Hypothalamus, Neuromodulators, Stress & Cortisol, Sleep Drugs & Ultrasound Technology | Luis de LeceaM&M #147: Ketamine: Opioid System, Sex Differences, S- vs. R- Isomers, Depression & Ultrasound Imaging Technology | Tommaso Di Ianni*This content is never meant to serve as medical advice.Support the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off. SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Learn all the ways you can support my efforts

Live Well Be Well
These Foods BOOST Your Blood-Brain Barrier | Dr. William Li | Be Well Moments

Live Well Be Well

Play Episode Listen Later Oct 14, 2024 13:17


Did you know your diet could be the secret weapon for protecting your brain? In this video, Dr. William Li uncovers how certain foods can fortify one of your brain's most vital but overlooked defenses – the blood-brain barrier. This essential filter shields your mind from harmful invaders, yet many people don't realize how everyday foods can help keep it strong and effective.Prepare to rethink your daily meals as Dr. Li reveals how specific foods may boost memory, clear brain fog, and strengthen your brain's natural defenses. Watch now and discover how these small dietary changes can have a profound impact on your mental resilience and overall brain health.Listen to the full episode here.Watch the full episode on YouTube here.***Thank you to my wonderful sponsors!BON CHARGE | Science-backed beauty, wellness and recovery products.https://boncharge.com/LIVEWELL?rfsn=8119877.ae1cd73Use code LIVEWELL for 15% off.OptimallyMe | Personalised insights for optimal health.https://bit.ly/lwbw20Use code LWBW20 for 20% off.Squarespace | A website makes it real.http://squarespace.com/LiveWellGet a free trial and use code LIVEWELL for 10% off your first website or domain purchase

Live Well Be Well
Dr. William Li: How Your Diet AFFECTS the Blood-Brain Barrier

Live Well Be Well

Play Episode Listen Later Sep 4, 2024 77:25


Dr. William Li is back on Live Well, Be Well!Mental health is a huge focus for me, and with good reason. Dementia's on the rise, and many people can resonate with the brain fog that comes as a consequence of our fast-paced world. But - did you ever think that being picky with food might mess with your mental health?Dr. William Li breaks down this new research for us, as we chat about how what we eat is so closely linked to our brain health. It's not just about food though - we get into the importance of moving your body, hanging out with friends, and that all-important thing called sleep.We also talk about ways to keep dementia at bay, with Dr. Li sharing some hopeful insights, as well as discussing the not so well known glymphatic system, which is like a brain car wash that only works when you're snoozing.Dr. William Li is a world-renowned physician, scientist, and author. His groundbreaking research has impacted over 70 diseases, including cancer, diabetes, heart disease, and obesity. He's one of the most sought-after medical experts in the field today.Let me know what you think, and don't forget to live well and be well!Sarah AnnHighlights:The Link Between Diet and Mental Wellbeing (0:00)Picky Eating Habits: New Research Reveals Surprising Mental Health Connections (0:52)Why a Varied Diet Matters for Mental Health (7:49)Exploring the Blood-Brain Barrier: Your Brain's Protective Shield (12:04)Mental Resilience: How Your Brain Adapts to Challenges (19:14)Brain Regeneration: Myth or Reality? Latest Findings Explored (25:06)Food as Medicine: Unlocking the Healing Power of Nutrition (36:07)Dementia and Alzheimer's: Understanding Risk Factors and Prevention Strategies (36:07)Move for Your Mind: The Brain-Boosting Benefits of Exercise (45:38)Why Social Connections Are Crucial for Brain Health (48:04)Sleep and Mental Health: The Science Behind a Good Night's Rest (49:19)A Glimpse into the Future of Medicine (1:03:41)Key Takeaways for a Healthier Brain and Body (1:08:57)***Thank you to my wonderful sponsors!BON CHARGE | Science-backed beauty, wellness and recovery products.Use code LIVEWELL for 15% off.OptimallyMe | Personalised insights for optimal health.Use code LWBW20 for 20% off.Squarespace | A website makes it real.Get a free trial and use code LIVEWELL for 10% off your first website or domain purchase.***If you enjoyed this episode you might also like:How to FIX Leaky Gut, Improve Health and Stop Cravings | Dr. James Kinrosshttps://youtu.be/YvupSI_S7_Q?si=_PnU0I87Ch-jkjXyDr. Will Bulsiewicz | Could SIBO be causing your IBS?https://youtu.be/m1bLLptcC2Q?si=8xyPDYXjtd39fXeG Nicole Vignola: The 7-Step Process to Rewire Your Brainhttps://youtu.be/JHn8z3w6AFQ How to FIX Leaky Gut, Improve Health and Stop Cravings | Dr. James Kinrosshttps://youtu.be/YvupSI_S7_Q ***Let's be friends!

The Synthesis of Wellness
136. Borrelia (Lyme) & The Brain - Neurological Manifestations of Chronic Lyme Disease, Blood-Brain Barrier Permeability, Symptoms, & Nervous System Support

The Synthesis of Wellness

Play Episode Listen Later Aug 16, 2024 25:12


In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations. Topics: 1. Introduction - Overview of Lyme disease and its causative agent, Borrelia burgdorferi. - Explanation of Borrelia's invasive nature and its ability to cross biological barriers like the blood-brain barrier (BBB). 2. Understanding the Blood-Brain Barrier (BBB) - Endothelial Cells: Primary cellular component of the BBB, unique to the brain for their tightly joined structure. - Astrocytes: - Role in regulating blood flow through neurovascular coupling. - Interaction with neurons and release of vasoactive substances. - Contribution to BBB integrity by influencing tight junction formation. - Pericytes: - Contribution to BBB permeability and regulation through contractile capabilities. 3. Sponsor Break: Daily Nouri 4. Pathophysiology of Borrelia in the Brain - Invasion Mechanisms: - Borrelia's ability to adhere to and invade endothelial cells. - Role of surface proteins and induction of matrix metalloproteinases (MMPs). - Immune Evasion and CNS Invasion: - Antigenic variation to avoid immune detection. - Triggering of immune responses within the CNS, involving microglia and peripheral immune cells. - Cytokine production and its consequences on neuronal health. 5. Direct Impact on Brain Cells - Neurons: Effects of Borrelia invasion on cellular functions, mitochondrial dysfunction, and apoptosis. - Astrocytes: Transition to reactive astrocytes in the presence of Borrelia and their role in neuroinflammation. - Oligodendrocytes: Impact on myelin production and implications for cognitive and motor functions. 6. Sponsor Break: AX3 Life 7. Neurological Symptoms and Manifestations - Symptoms Overview: Headaches, facial palsy, cognitive impairments, nerve root inflammation, POTS. - Psychiatric Manifestations: Potential psychological symptoms like depression and anxiety due to neuroinflammation. 8. Conclusion - Importance of addressing neurological symptoms of Lyme through a bioindividual and root-cause approach. - Recap of key points and reference to previous relevant episodes for further listening. Thank you to our episode sponsors: Check out Daily Nouri and use code CHLOE20 for 20% off your order. Check out ⁠AX3 Astaxanthin⁠ and use discount code ⁠CHLOE20⁠ for 20% off your first order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Pursuit of Wellness
Husband/Founders Chat: Bloom Energy Drink, Addressing The Haters, Relationship Advice & Motivation for Entrepreneurs

Pursuit of Wellness

Play Episode Listen Later Jul 25, 2024 43:03


Ep. # 119 On today's Pursuit of Wellness episode, Greg is back to dive into the details of our exciting NEW product, the Bloom energy drink! We'll explore the challenges of creating an energy drink, our commitment to balancing health and flavor, and a breakdown of the ingredients we chose and why. Together, Greg and I address the haters while providing motivation for female entrepreneurs. We also answer your questions on relationship advice, managing bad days, finding balance with each other, and provide fertility updates. Tune in for an intimate and personal episode with Greg and me! Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Greg's Instagram click here! For POW Brand Promo Codes click here! Sponsored By:  Visit clearstemskincare.com and use code POW at checkout for 20% off your first purchase. Again, that's code POW for 20% off your first purchase on https://clearstem.com/ Get better sleep now with Blissy and use POWPOD to get an additional 30% off at blissy.com/POWPOD Sleep is the foundation of health, and there is nothing better than waking up feeling refreshed and ready to attack the day. Use code POW for 20% off your order at https://dreamrecovery.io/ Show Links: New Bloom Energy Drinks! Sucralose Bypasses the Blood Brain Barrier?  New Research Shows Artificial Sweeteners Mess Up Your Gut? Topics Discussed: 00:11 - Welcome back Greg! 01:00 - Travel and lifestyle updates 03:20 - Phone “Check Ins” 04:28 - Greg's trip to LA 06:22 - Relationship advice and finding balance 09:21 - Fertility updates 10:38 - Greg's thoughts on expectations 15:19 - Bloom energy drinks 23:03 - Analyzing the ingredients in Bloom 31:45 - Greg's social media presence 32:45 - Key financial and investment advice 33:51 - Managing each other's bad days 34:51 - Mari's father and acclimating to America 38:26 - Fighting with each other 39:33 - Investments and getting acquired 39:38 - Relationship vs Mari's fitness journey 41:04 - Where to find Bloom energy drinks

ImmunoTea: Your Immunology Podcast
ImmunoTea Episode 19 - The Blood Brain Barrier and Long COVID

ImmunoTea: Your Immunology Podcast

Play Episode Listen Later Jul 14, 2024 38:07


On this episode Lara and Vyanka talk to Dr Matthew Campbell all about the blood brain barrier, what it is, how it works, how it's manipulated and the BBB in long COVID. This is ImmunoTea: Your Immunology Podcast, presented by Dr Lara Dungan and Dr Vyanka Redenbaugh. This is the show where we tell you all about the most exciting research going on in the world of immunology. So grab a cup of tea, sit down and relax and we'll fill you in. Contact us at ImmunoTeaPodcast@gmail.com or @ImmunoTea on twitter. Hosted on Acast. See acast.com/privacy for more information.

Medical Medium Podcast
042 Blood Brain Barrier: Gets Penetrated

Medical Medium Podcast

Play Episode Listen Later Feb 8, 2024 23:44


Nearly everything toxic can end up at some point in time crossing the Blood Brain Barrier. Virtually every man-made toxin and poison on this planet can cross through the barrier, the sacred wall that mysteriously sits in our head. You go to the gas station, you start pumping gas into your tank and breathing in fumes, those fumes cross the Blood Brain Barrier. Or as you are driving an EV and are sitting on a very large battery and breathing in vapors that outgas off of car batteries, even if the battery is located in a different area of the car, small amounts of outgas occur over time and cross the Blood Brain Barrier. Everyday we get exposed from hundreds and hundreds of toxins. We get exposed to Pharmaceuticals, Toxic Heavy Metals, Pathogens, Pesticides, Herbicides, Fungicides, Solvents, Petrochemicals, Fragrances, Chemtrails and so much more, and as these exposures enter our bodies, they find a way to our brain by crossing the Blood Brain Barrier. We are led to believe it's very hard for any substance to cross the Blood Brain Barrier. We are told only certain pharmaceuticals can achieve crossing over the barrier purposely designed this way for our health, but it's so much more than what we are told. Listen to this surprising, powerful, informative Medical Medium podcast on the Blood Brain Barrier. For more information visit www.medicalmedium.com