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We are taking a look at everything we missed over the break including Adam Sandler's Whole Lotta Love for Sammy Hagar, Ozzy Suicide Pacts, Bret Michaels news, Corey Feldman's doc drama with sexual abuse allegations against Corey Haim, Major things happening with Jelly Roll and the biggest flops of last year.MUSICSammy Hagar, Mick Fleetwood and Duff McKagan performed on New Year's Eve in Maui at a benefit for the Maui Health Foundation. Among those on hand was actor Adam Sandler, who helped Hagar sing Led Zeppelin's “Whole Lotta Love.” Hagar and Fleetwood posted highlights on Instagram. Hagar also posted a New Year message in which he says he'll do “more of the same” in 2026. https://www.youtube.com/shorts/tTWgVVuLyBA · Sharon Osbourne Explained Why She Didn't Follow Through with Her and Ozzy's Suicide PactSharon Osbourne credits her kids for keeping her alive. She previously made headlines for revealing in a 2007 memoir that she and Ozzy had an assisted suicide pact should either of them get dementia.Sharon didn't follow through with that pact, because of her kids. She said if it weren't for them, she'd have gone with Ozzy because she's done everything she's wanted to do in this life.She added, quote, "Years ago, when I had one of my mental breakdowns, I went into a little facility to help with my head. There were two girls over there. They didn't know each other, but they were in there, each [of their] mothers had committed suicide. "I saw the state that these two young women were in and what it had done to their lives, and I thought, I will never, ever, ever do that to my kids." Bret Michaels Fans, Get Ready: A Biopic and Book Are Dropping in 2026If you've been waiting for a deep dive into the life of Poison's frontman, mark your calendars. Bret Michaels has officially announced that he is releasing both a biopic and a new book in 2026. Jelly Roll Says His Weight Loss Helped Him See in Color AgainJelly Roll sat down with Joe Rogan recently and had a wild story to share. He told Joe that for over twenty years, he was colorblind. Here's what Jelly said, "I [could] see shades of colors. General concepts. I never realized there was nuances and prettiness." https://www.eonline.com/news/1426170/jelly-roll-on-200-lb-weight-loss TVMajor Shakeup: The Oscars Are Leaving ABC for YouTubeGet ready for a massive change in how we watch the Academy Awards. In a move that is sending shockwaves through Hollywood, the Academy has announced that the Oscars will be leaving ABC—their home since 1976—and moving exclusively to YouTube. Like Mother, Like Son: Judge Judy's Son Lands His Own Courtroom ShowJudge Judy Sheindlin (SHINED-LIN) is officially passing the gavel to the next generation. Her son, Adam Levy, is set to star in his very own courtroom series called Adam's Law. MOVING ON INTO MOVIE NEWS:Over the break, we found out that a new documentary about Corey Feldman is coming out. And in this doc there were allegations about Corey Haim, his costar in Lost Boys molested him while filming. Then a week later, he is now denying those claims. https://pagesix.com/2025/12/20/celebrity-news/corey-feldman-walks-back-claim-that-corey-haim-molested-him/ · Mickey Rourke has turned to a GoFundMe campaign to help stave off eviction from his Los Angeles home after falling nearly $60,000 behind on rent, People magazine reports. https://people.com/mickey-rourke-using-gofundme-prevent-eviction-after-falling-nearly-usd60k-behind-rent-11878821?· Wild New Lawsuit Allegation: Is Riley Keough the Biological Mother of John Travolta's Son?Okay, there is some truly bizarre legal drama unfolding involving the Presley family and John Travolta. A new lawsuit has dropped a massive bombshell, alleging that Riley Keough is actually the biological mother of John Travolta and Kelly Preston's youngest son, Ben. AND FINALLYHollywood's Biggest Faceplants: The 10 Most Disappointing Flops of 20252025 had its hits, but let's be honest—it was also a year where some massive blockbusters crashed and burned. From superhero fatigue to Oscar-bait that nobody bit on, here's a look at the ten movies that just couldn't get audiences into seats this year. 1. Thunderboltsa. Marvel is definitely feeling the pain. While this movie made nearly $400 million, that's peanuts compared to the glory days of Avengers: Endgame. It suffered from the same problem as Captain America: Brave New World: it just felt like reheated leftovers from a saga that ended years ago. Aside from Superman, it looks like superhero fatigue has officially set in. 1. Snow Whitea. This was the exception to the rule that Disney remakes print money. It didn't even make back its budget. The movie had an identity crisis—trying to be both a classic recreation and a subversive twist—but the real killer was the PR nightmare. Between the casting controversies and political debates, the movie was "covered in mud" before it even hit theaters. 1. Mickey 17a. Everyone was dying to see what director Bong Joon Ho would do after Parasite. The problem? We waited too long. After endless delays, the hype died. When it finally dropped in February, reviews called it "toothless" and confused. Even Robert Pattinson couldn't save this sci-fi epic from being a disappointment. 1. After the Hunta. You'd think Julia Roberts and the director of Call Me by Your Name would be a slam dunk. Nope. It made less than $10 million globally (which is like, half of Roberts' salary). The movie was too long, too rambling, and felt more like a streaming series than a cinema event. 1. Christya. Sydney Sweeney is everywhere, but apparently, that doesn't guarantee box office sales. Her boxing biopic had one of the worst opening weekends ever for a wide release. It seems social media fame doesn't always translate to ticket sales. Sweeney defended it, saying she made it for "impact," not numbers, which is good, because the numbers were bad. 1. I Know What You Did Last Summera. Studios thought they could pull a Scream with this 90s revival. The issue? People actually love Scream. Nobody really cares about "The Fisherman" or the original 1997 film enough to show up for a legacy sequel. 1. Springsteen: Deliver Me from Nowherea. Jeremy Allen White played The Boss, but audiences didn't show up. Why? Because the movie focused on a depressing, quiet period of Bruce Springsteen's life where he moped around a bedroom recording acoustic tracks. People wanted the stadium anthems and energy, not the gloom. 1. Elio a. Pixar had a huge win with Inside Out 2, but Elio brought them back down to earth. The original director left mid-production, and the final product felt like a movie with no reason to exist. It was hard to explain the plot, and audiences just didn't connect with the aliens. 1. M3GAN 2.0a. The first M3GAN was a viral hit because it was campy, slasher fun. The sequel failed because it tried to pivot into a sprawling, geopolitical action thriller. The producers admitted they overthought it—they should have just given the people more of the killer doll they loved. 1. The Smashing Machinea. Dwayne "The Rock" Johnson really wants an Oscar. He teamed up with Emily Blunt and an indie director for this gritty MMA drama. But here's the thing: nobody goes to a Rock movie to be depressed. It was a bleak story about addiction, and audiences preferred to stay home. 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A feckless Chief Justice who is obviously trying to avoid being attacked by his favorite president Trump, issued a worthless “Final Report” on this past year at the Judiciary, filled with misstatements, omissions and misleading “statistics”. Missing from the report? Any mention of Trump's attacks on the Judiciary, Judges, Lawyers and Law Firms, the violence threatened against them, the use of rogue US Attorneys to go after Trump's political enemies, the corruption of the DOJ, the lack of ethics at the Supreme Court, and the battle that has spilled into the open between the lower federal trial courts and the Supreme Court, or the Court being complicit with Trump through the use of the “shadow docket” to allow back door appeals to side with Trump 86% of the time. Michael Popok blows apart the Report and its attempt to wrap Roberts and judges in a flag to fool the American people into believing that the Third Branch hasn't been captured by MAGA and Trump. Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast Cult Conversations: The Influence Continuum with Dr. Steve Hassan: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan Mea Culpa with Michael Cohen: https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show Burn the Boats: https://www.meidastouch.com/tag/burn-the-boats Majority 54: https://www.meidastouch.com/tag/majority-54 Political Beatdown: https://www.meidastouch.com/tag/political-beatdown On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices
Scott interviews Jason Jones from the Vulnerable People Project about why American Christians are wrong to see the Israeli government as an ally. Discussed on the show: The Jews by Hilaire Belloc “The Hindutva Lobby” (Harper's Magazine) The Vulnerable People Project Jason Jones is a film producer, author, activist, popular podcast host, and dedicated human rights worker. And he is the founder and president of The Vulnerable People Project. Subscribe to his Substack. Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow Learn more about your ad choices. Visit megaphone.fm/adchoices
Download Audio. Scott interviews Jason Jones from the Vulnerable People Project about why American Christians are wrong to see the Israeli government as an ally. Discussed on the show: The Jews by Hilaire Belloc “The Hindutva Lobby” (Harper's Magazine) The Vulnerable People Project Jason Jones is a film producer, author, activist, popular podcast host, and dedicated human rights worker. And he is the founder and president of The Vulnerable People Project. Subscribe to his Substack. Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott’s work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott’s other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott’s books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow
In 2016, Tara Roberts was living in Washington D.C. and working at a nonprofit when she visited the National Museum of African American History and Culture and a photograph she saw there changed her life. The image was of Black scuba divers from the group Diving with a Purpose which searches for and documents slave shipwrecks around the world. Roberts quit her job, learned to scuba dive and chronicled the work of these scuba divers. Her book about that journey is “Written in the Waters: A Memoir of History, Home and Belonging.”
January First is the Solemnity of Mary, Mother of God, a Holy Day of Obligation for Catholics (meaning that Mass attendance is required), also observed by some Protestants (Anglicans & Lutherans) as a related feast. On this day, the Church proclaims Mary as Theotokos (God-bearer), affirming that the Son she conceived by the power of the Holy Spirit is truly God and truly man. The Solemnity of the Blessed Virgin Mary is thus a liturgical celebration observed on January 1st and marks the octave of Christmas, celebrating her divine motherhood. Bishop Robert Barron books available at https://amzn.to/44W7nwN Breathe Bible Audio CD available at https://amzn.to/3CPRa4x Saint of the Day podcast with M. Roberts at https://ourcatholicradio.org/programs/saint-day Gospel of Luke available at https://amzn.to/3M6sTId ENJOY Ad-Free content, Bonus episodes, and Extra materials when joining our growing community on https://patreon.com/markvinet SUPPORT this channel by purchasing any product on Amazon using this FREE entry LINK https://amzn.to/3POlrUD (Amazon gives us credit at NO extra charge to you). Mark Vinet's HISTORY OF NORTH AMERICA podcast: www.parthenonpodcast.com/history-of-north-america Mark's TIMELINE video channel: https://youtube.com/c/TIMELINE_MarkVinet Website: https://markvinet.com/podcast Facebook: https://www.facebook.com/mark.vinet.9 Twitter: https://twitter.com/HistoricalJesu Instagram: https://www.instagram.com/denarynovels Mark's books: https://amzn.to/3k8qrGM Audio credits: Breathe Bible podcast (LifeAudio Podcast Network, Salem Web Network); Bishop Barron’s Sunday Sermons-Herod and Joseph, 25dec2019 (Word on Fire Catholic Ministries); Saint of the Day with Mike Roberts-January 1 Solemnity Of The Blessed Virgin Mary, Jan. 1, 2024 (Covenant Network). Saint of the Day podcast: The Flight into Egypt of the Holy Family (26dec2023), Greek Orthodox Deacon Jerome Atherholt and Ancient Faith Radio. The Saint of the Day podcast (S1E319 St. Joseph 19mar2023). Saint of the Day with Mike Roberts: Solemnity Of Saint Joseph (episode e324, 19mar2024). Audio excerpts reproduced under the Fair Use (Fair Dealings) Legal Doctrine for purposes such as criticism, comment, teaching, education, scholarship, research and news reporting. See omnystudio.com/listener for privacy information.
Scott interviews Larry Johnson about Ukraine's alleged assassination attempt against Putin, why European leaders seem so set on continuing the war in Ukraine, Trump's naval build up near Venezuela, the risk of a terror attack in the US and more. Discussed on the show: “Did Ukraine Try to Kill Putin?” (Sonar21) “Why is Susan Miller Doing Media?” (Sonar21) Anatomy of the State by Murray Rothbard Larry C. Johnson is a former CIA officer and intelligence analyst, and a former planner and advisor at the US State Department's Office of Counter Terrorism. Follow his analysis at Sonar21. Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow Learn more about your ad choices. Visit megaphone.fm/adchoices
Chancellor Lee Roberts has been on the job at the University of North Carolina for nearly two years and in that time, the landscape of college athletics has changed dramatically. Inside Carolina's Greg Barnes and Tommy Ashley discuss the past two years of Roberts's tenure, the decisions made and the decisions ahead. This show is brought to you by Inside Carolina, the No. 1 site for UNC sports coverage and community. Visit http://www.InsideCarolina.com Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.
Download Audio. Scott interviews Larry Johnson about Ukraine's alleged assassination attempt against Putin, why European leaders seem so set on continuing the war in Ukraine, Trump's naval buildup near Venezuela, the risk of a terror attack in the US and more. Discussed on the show: “Did Ukraine Try to Kill Putin?” (Sonar21) “Why is Susan Miller Doing Media?” (Sonar21) Anatomy of the State by Murray Rothbard Larry C. Johnson is a former CIA officer and intelligence analyst, and a former planner and advisor at the US State Department's Office of Counter Terrorism. Follow his analysis at Sonar21. Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow
Shunji Tomatsu, MD, PhD, Professor and Head, Nemours Children's Health, Delaware, USA; Alessandra d'Azzo, PhD, Emerita Faculty, Genetics, St. Jude Children's Research Hospital, Tennessee, USA; Merve Emecen Sanli, MD, Associate Professor, Department of Pediatrics, University of Texas Southwestern Medical Center, Texas, USA; and Ryan Colburn, patient with Pompe disease and president of Odimm Inc, discuss new and emerging gene therapies for lysosomal disorders.This continuing education activity is provided through collaboration between the Lysosomal and Rare Disorders Research and Treatment Center (LDRTC), CheckRare CE, and AffinityCE. This activity provides continuing education credit for physicians, physician assistants, nurses, nurse practitioners, and genetic counselors. A statement of participation is available to other attendees.To obtain CME/CE credit, please visit https://checkrare.com/learning/p-grids2025-session6-current-issues-in-gene-therapies-for-lysosomal-disorders/ Learning ObjectivesDescribe current and emerging gene therapy data in lysosomal disorders and its clinical relevanceDescribe role of patients in gene therapy developmentFacultyShunji Tomatsu, MD, PhD, Professor and Head, Nemours Children's HealthAlessandra d'Azzo, PhD, Emerita Faculty, Genetics, St. Jude Children's Research HospitalMerve Emecen Sanli, MD, Associate Professor, Department of Pediatrics, University of Texas Southwestern Medical CenterRyan Colburn. Odimm, Inc.DisclosuresAffinityCE staff, LDRTC staff, planners, and reviewers, have no relevant financial relationships with ineligible companies to disclose. Faculty disclosures, listed below, will also be disclosed at the beginning of the Program.Shunji Tomatsu, MD, PhD Dr. Tomatsu has received the following grants: Morquio Foundations and families: Scarlett Grifith, Bennett, A Cure for Roberts, and Morquio Conference; MPS Societies: Japanese, National, and Austrian; NIH grants: 1-R01-HD102545, NIH, NICHD, Tomatsu (PI), 1R01HD104814-01A1, NIH, NICHD, Langan, T.J. (PI), Role: Site-PI, R43HD114328-01, NIH, ACOSTA, WALTER (PI), Role: site PI, 1R43AR084638-01, NIH, MOUNZIH, KHALID (PI); Foundation of NIH: FNIH RFP NUMBER: 2022-BGTC-005 Tomatsu (PI). Alessandra d'Azzo, PhDDr. D'Azzo has no relevant financial relationships to disclose.Merve Emecen Sanli, MDDr. Sanli has no relevant financial relationships to disclose.Ryan ColburnMr. Colburn has an advisory, consulting and/or project based relationship or stock holding with: Abeona Therapeutics, Amicus Therapeutics, Astellas Gene Therapies, Avidity Biosciences, Bayer, Catalyst Pharmaceuticals, Denali Therapeutics, M6P Therapeutics, Sangamo Therapeutics, Sanofi, Solid Biosciences.Mitigation of Relevant Financial RelationshipsAffinityCE adheres to the ACCME's Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity. Conflicts of interest for presenting faculty with relevant financial interests were resolved through peer review of content by a non-conflicted reviewer.Accreditation and Credit DesignationPhysiciansThis activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AffinityCE and the LDRTC. AffinityCE is accredited by the ACCME to provide continuing medical education for physicians.AffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Physician AssistantsAffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Physician Assistants should claim only the credit commensurate with the extent of their participation in the activity.NursesAffinityCE is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation (ANCC). This activity provides a maximum of 1 hours of continuing nursing education credit.Nurse PractitionersAffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Nurse practitioners should claim only the credit commensurate with the extent of their participation in the activity.Genetic CounselorsAffinityCE designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credits™. Genetic Counselors should claim only the credit commensurate with the extent of their participation in the activity.Other ProfessionalsAll other health care professionals completing this continuing education activity will be issued a statement of participation indicating the number of hours of continuing education credit. This may be used for professional education CE credit. Please consult your accrediting organization or licensing board for their acceptance of this CE activity. Participation CostsThere is no cost to participate in this activity.CME InquiriesFor all CME policy-related inquiries, please contact us at ce@affinityced.comSend customer support requests to cds_support+ldrtc@affinityced.com
12/29/2025 – Karolyne Roberts –on striving less and living more with God as your guide
It's our final episode for 2025, so we've got 2 plus hours of hockey talk for all you beauties out there!We'll start off talkin' about the 2007-08 Penguins, who were captained by a 19 year old Sidney Crosby - maybe you've heard of him! He lead the Pens to the cusp of Lord Stanley for the first time, joined by the young core of Malkin, LeTang and Fleury and some old dogs like Roberts, Gonchar, Sydor and Sykora. Though the lost out in 6 to the Red Wings, it was only a taste of what was yet to com!In the extended second, we're talkin' World Junior's, we try and fix the Jets and then make some Olympic team predictions - so many questions, too many answers, who knows what's yet to come!And in the third, we've got lists o' plenty - some of our favourites from 2025. Plus we play some of our favourite tracks from the year that was!
Scott interviews Trita Parsi about Netanyahu's renewed effort to get Trump to bomb Iran on Israel's behalf. Discussed on the show: “As expected, Netanyahu back demanding more war with Iran” (Responsible Statecraft) Trita Parsi is the Executive Vice President of the Quincy Institute for Responsible Statecraft and the author of Losing an Enemy: Obama, Iran and the Triumph of Diplomacy.Parsi is the recipient of the 2010 Grawemeyer Award for Ideas Improving World Order. Follow him on Twitter @tparsi Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, Mary Sullivan, co-founder of Sweet but Fearless, talks with Julie Kay Roberts, President of JK Roberts and Founder of Emergency Management Association, about risk, self-advocacy, and knowing your worth. Julie shares the risks she took along the way and what it really looks like to stand up for yourself, ask for what you want, and speak with clarity even when it feels uncomfortable. The conversation also explores how leaders should think about AI in today's workforce: not as a crutch, but as a tool, one that supports your work without replacing your voice or judgment. Drawing on her deep expertise, Julie offers a clear, accessible overview of how emergency communication works, why collaboration matters in high-stakes moments, and how effective leaders show up to solve problems together. At the heart of it all is a powerful reminder: leadership isn't about having all the answers, it's about using your voice, trusting your value, and working side-by-side to find the solution. Julie is the President of JK Roberts, LLC, a consulting firm specializing in crisis communication, strategic planning, emergency management, media relations, and continuity planning. ABOUT JULIE KAY ROBERTS: Website: JK Roberts, LLC LinkedIn: Julie Kay Roberts ABOUT SWEET BUT FEARLESS: Website - Sweet but Fearless LinkedIn - Sweet but Fearless
Download Audio. Scott interviews Trita Parsi about Netanyahu's renewed effort to get Trump to bomb Iran on Israel's behalf. Discussed on the show: “As expected, Netanyahu back demanding more war with Iran” (Responsible Statecraft) Trita Parsi is the Executive Vice President of the Quincy Institute for Responsible Statecraft and the author of Losing an Enemy: Obama, Iran and the Triumph of Diplomacy. Parsi is the recipient of the 2010 Grawemeyer Award for Ideas Improving World Order. Follow him on Twitter @tparsi Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow
On this week's Labor History Today: From Camp Solidarity in Matewan, West Virginia—the heart of the legendary Mine Wars—UMWA President Cecil Roberts reflects on the long struggle of coal miners to claim America's promise that “this land belongs to all of us.” On the eve of his retirement, Roberts' words connect today's fights for justice with a century of labor history rooted in the hollers of Appalachia. (Originally broadcast 9/21/25; updated with today's Labor History in 2:00) Questions, comments, or suggestions are welcome, and to find out how you can be a part of Labor History Today, email us at LaborHistoryToday@gmail.com Labor History Today is produced by the Labor Heritage Foundation and the Kalmanovitz Initiative for Labor and the Working Poor. #LaborRadioPod #History #WorkingClass #ClassStruggle @GeorgetownKILWP #LaborHistory @UMDMLA @ILLaborHistory @AFLCIO @StrikeHistory #LaborHistory @wrkclasshistory
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This year, December 28th is the Feast of the Holy Family or Holy Family Sunday, also known as the Fourth Day within the Octave of the Nativity of the Lord or Octave of Christmas. The Feast of the Holy Family is a movable feast, celebrated in the Roman Catholic and Coptic Churches and in many Protestant Anglican and Lutheran churches. The celebration emphasizes Jesus, Mary, and Joseph as a model of family virtue, faith, and love, promoting family unity and devotion to God, and presenting the Holy Family as the model and exemplar of all Christian families. Bishop Robert Barron books available at https://amzn.to/44W7nwN The Saint of the Day podcast at https://amzn.to/4cpIyyt Saint of the Day podcast with J. Atherholt at https://ancientfaith.com Saint of the Day podcast with M. Roberts at https://ourcatholicradio.org/programs/saint-day Joseph of Nazareth books available at https://amzn.to/4aVqVpa Gospel of Matthew available at https://amzn.to/3sxXmZS ENJOY Ad-Free content, Bonus episodes, and Extra materials when joining our growing community on https://patreon.com/markvinet SUPPORT this channel by purchasing any product on Amazon using this FREE entry LINK https://amzn.to/3POlrUD (Amazon gives us credit at NO extra charge to you). Mark Vinet's HISTORY OF NORTH AMERICA podcast: www.parthenonpodcast.com/history-of-north-america Mark's TIMELINE video channel: https://youtube.com/c/TIMELINE_MarkVinet Website: https://markvinet.com/podcast Facebook: https://www.facebook.com/mark.vinet.9 Twitter: https://twitter.com/HistoricalJesu Instagram: https://www.instagram.com/denarynovels Mark's books: https://amzn.to/3k8qrGM Audio credits: Bishop Barron’s Sunday Sermons-Herod and Joseph, 25dec2019 (Word on Fire Catholic Ministries). Saint of the Day podcast: The Flight into Egypt of the Holy Family (26dec2023), Greek Orthodox Deacon Jerome Atherholt and Ancient Faith Radio. The Saint of the Day podcast (S1E319 St. Joseph 19mar2023). Saint of the Day with Mike Roberts: Solemnity Of Saint Joseph (episode e324, 19mar2024). Audio excerpts reproduced under the Fair Use (Fair Dealings) Legal Doctrine for purposes such as criticism, comment, teaching, education, scholarship, research and news reporting.See omnystudio.com/listener for privacy information.
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Over the past calendar year, the Supreme Court's center has shifted to the right and then more to the right, and the justices' decisions have time and again facilitated Trump's agenda. But the Roberts majority is not simply focused on what the current president wants; it has its sights set on a larger project: voting. Suppressing and constraining and problematizing the core function of democratic rule. In this episode, Dahlia Lithwick and Mark Joseph Stern reflect on the significant developments at the Supreme Court over the past year with an eye toward the implications of the court's decisions on democracy, voting rights, and the erosion of checks and balances. Looking back at the past year at One First Street, Dahlia and Mark trace the cases that reveal the court's long game, with elections coming quickly, and discuss the forces for and against democracy being exerted within and without the high court. Then, they turn to the urgent matter of what you and I can do about it. If you want to access that special 50% discount for Slate Plus membership, go to slate.com/amicusplus and enter promo code AMICUS 50. This offer expires on Dec 31st 2025. Learn more about your ad choices. Visit megaphone.fm/adchoices
Over the past calendar year, the Supreme Court's center has shifted to the right and then more to the right, and the justices' decisions have time and again facilitated Trump's agenda. But the Roberts majority is not simply focused on what the current president wants; it has its sights set on a larger project: voting. Suppressing and constraining and problematizing the core function of democratic rule. In this episode, Dahlia Lithwick and Mark Joseph Stern reflect on the significant developments at the Supreme Court over the past year with an eye toward the implications of the court's decisions on democracy, voting rights, and the erosion of checks and balances. Looking back at the past year at One First Street, Dahlia and Mark trace the cases that reveal the court's long game, with elections coming quickly, and discuss the forces for and against democracy being exerted within and without the high court. Then, they turn to the urgent matter of what you and I can do about it. If you want to access that special 50% discount for Slate Plus membership, go to slate.com/amicusplus and enter promo code AMICUS 50. This offer expires on Dec 31st 2025. Learn more about your ad choices. Visit megaphone.fm/adchoices
Over the past calendar year, the Supreme Court's center has shifted to the right and then more to the right, and the justices' decisions have time and again facilitated Trump's agenda. But the Roberts majority is not simply focused on what the current president wants; it has its sights set on a larger project: voting. Suppressing and constraining and problematizing the core function of democratic rule. In this episode, Dahlia Lithwick and Mark Joseph Stern reflect on the significant developments at the Supreme Court over the past year with an eye toward the implications of the court's decisions on democracy, voting rights, and the erosion of checks and balances. Looking back at the past year at One First Street, Dahlia and Mark trace the cases that reveal the court's long game, with elections coming quickly, and discuss the forces for and against democracy being exerted within and without the high court. Then, they turn to the urgent matter of what you and I can do about it. If you want to access that special 50% discount for Slate Plus membership, go to slate.com/amicusplus and enter promo code AMICUS 50. This offer expires on Dec 31st 2025. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Wine Crush Podcast, we sit down with the team behind Irvine & Roberts Vineyards, one of Southern Oregon's standout producers known for their high-elevation sites and refined, expressive wines.We explore the inspiration behind the brand, the unique characteristics of the Rogue Valley AVA, and how thoughtful farming and winemaking decisions shape their elegant portfolio. From vineyard challenges to standout varietals, this conversation highlights the passion, precision, and sense of place that define Irvine & Roberts.Whether you're an Oregon wine fan or just discovering the region, this episode offers insight, heart, and plenty of wine crush-worthy moments.
In this episode of the Wine Crush Podcast, we sit down with the team behind Irvine & Roberts Vineyards, one of Southern Oregon's standout producers known for their high-elevation sites and refined, expressive wines.We explore the inspiration behind the brand, the unique characteristics of the Rogue Valley AVA, and how thoughtful farming and winemaking decisions shape their elegant portfolio. From vineyard challenges to standout varietals, this conversation highlights the passion, precision, and sense of place that define Irvine & Roberts.Whether you're an Oregon wine fan or just discovering the region, this episode offers insight, heart, and plenty of wine crush-worthy moments.
This episode features Naomi Titleman meeting with Glain Roberts-McCabe, Founder & President of The Roundtable Inc. They dive deep into high-potential talent research, exploring what engages top performers and what causes them to burn out. This episode features insights from Roundtable's latest research on high-potential leaders.Key discussion topics include:Defining High Potentials:Balance between driving results and maintaining cultural alignmentCore motivational drivers: helping others, excelling, adaptabilityBehavioral expectations vs. underlying motivational energyWhat Engages High Potentials:Clarity: Clear priorities and understanding of goalsTransparency: Honest career conversations and realistic expectations Quality career discussions: Beyond linear promotion pathsCross-functional opportunities:Leveraging adaptive strengths across organizationMajor Barriers & Burnout Risks:Firefighting mode: 45% of respondents stuck in reactive workUnclear priorities: Moving goalposts without contextResource constraints: Ambitious targets without adequate supportDevelopment crowding: Operational demands overshadowing growth opportunitiesEvolving Leadership Requirements:Strategic thinking: Increased emphasis on forward-thinking capabilitiesTechnical depth: Leaders need subject matter expertise, not just general managementCooperation: Willingness to trade individual agendas for organizational benefitYou can learn more about the research here:https://goroundtable.com/the-2026-roundtable-report-on-high-potential-leaders/And follow Glain on LinkedIn here:https://www.linkedin.com/in/glain/Don't forget …To sign up for our monthly newsletter foHRsight at http://www.futurefohrward.com/subscribe.Follow us on LinkedIn:Mark - www.linkedin.com/in/markedgarhr/Naomi - www.linkedin.com/in/naomititlemancolla/future foHRward - www.linkedin.com/company/future-fohrward/And on Instagram - www.instagram.com/futurefohrward/Support the show
Scott interviews USS Liberty survivor, author and spokesperson Phil Tourney. They talk about what really happened the day of the attack, the infuriating lengths the US government went to ensure nobody would find out about it and the continued effort by figures and groups in the conservative movement to shut down discussion about this heinous chapter of US-Israeli relations. Discussed on the show: What I Saw That Day by Phil Tourney and Mark Glenn BBC's USS Liberty: Dead in the Water (IMDb) The Day Israel Attacked America | Al Jazeera Sacrificing Liberty Operation Cyanide: How the Bombing of the USS Liberty Nearly Caused World War Three by Peter Hounam Pre-Order Phil's New Book Phillip F. Tourney is a decorated U.S. Navy Veteran, survivor of the 1967 USS Liberty attack, and recipient of the Bronze Star V and Purple Heart. Prior to Liberty, he did two tours on the USS Mauna Kea in waters off Vietnam. For his actions during the Liberty attack, he received a Bronze Star with “V” device plus a Purple Heart. He's been President (or multiple-term President) of the USS Liberty Veterans Association. Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow Learn more about your ad choices. Visit megaphone.fm/adchoices
Download Audio. Scott interviews USS Liberty survivor, author and spokesperson Phil Tourney. They talk about what really happened the day of the attack, the infuriating lengths the US government went to ensure nobody would find out about it and the continued effort by figures and groups in the conservative movement to shut down discussion about this heinous chapter of US-Israeli relations. Discussed on the show: What I Saw That Day by Phil Tourney and Mark Glenn BBC's USS Liberty: Dead in the Water (IMDb) The Day Israel Attacked America | Al Jazeera Sacrificing Liberty Operation Cyanide: How the Bombing of the USS Liberty Nearly Caused World War Three by Peter Hounam Pre-Order Phil's New Book Phillip F. Tourney is a decorated U.S. Navy Veteran, survivor of the 1967 USS Liberty attack, and recipient of the Bronze Star V and Purple Heart. Prior to Liberty, he did two tours on the USS Mauna Kea in waters off Vietnam. For his actions during the Liberty attack, he received a Bronze Star with “V” device plus a Purple Heart. He's been President (or multiple-term President) of the USS Liberty Veterans Association. Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow
Aaron Roderick & Chase Roberts Media Availability
In this episode, I interview Brittany Roberts, the mastermind behind the Instagram Launch Lab, about her innovative product launch methods that emphasize simplicity and creativity.Brittany helps online coaches and creatives build launches that everyone wants a piece of — by turning Instagram into their hottest launch asset.She's an award-winning Social Media Manager and the creator of Instagram Launch Lab, where she teaches a show-stopping, scroll-stopping strategy that transforms casual followers into paying clients.Brittany has led organic strategy for multiple six- and seven-figure women-led brands, and created standout campaigns for names like My Muscle Chef, Royal Caribbean, and Later.Since starting her own brand in 2020, she has coached hundreds of women internationally and grown an engaged Instagram audience from scratch.Brittany is a creativity-led strategist, and the host of The One Woman Show — which debuted at #3 in the Australian Marketing Charts.Key takeaways from this episode include:Evolving Launch Strategies: Brittany shares her shift from traditional funnels to using Instagram's "Close Friends" for more relaxed audience engagement.Curated Content: Short, engaging videos allow followers to learn without feeling overwhelmed, making content digestible.Simple Launch Processes: A three-day training series can effectively foster engagement without complexity.Boosting Participation: Gamified elements and exclusivity enhance interaction rates with her audience.Soft Selling Techniques: Gradual calls to action lead participants through a nurturing process to a final offer.Feedback for Improvement: Continuous refinement of her approach based on audience reactions drives success.Brittany's success illustrates how simplifying launches can lead to substantial results. Tune in for actionable insights to elevate your launch strategy!Chapters:0:00: Introduction to a New Launch Strategy1:16: The Shift Away from Fancy Funnels5:10: Embracing Instagram Stories for Engagement9:24: Building Exclusivity with Close Friends14:58: Innovative Ways to Opt-In19:59: The Close Friends List Strategy25:59: Adapting to Changing Marketing Strategies27:14: Content Structure for Instagram Stories30:48: Educational Challenges and Takeaways38:48: Call to Action and Conversion Strategies46:55: Planning and Prep for Launch Series52:21: Wrapping Up and Resources AvailableEmail Brittany: brittany@thesocialbritify.comShe can be found on socials @thesocialbritifyThe Instagram Launch Lab: https://thesocialbritify.com/instagram-launch-labCan We Be Honest About Launching? Podcast: https://podcasts.apple.com/bb/podcast/can-we-be-honest-about-launching-the-campaign/id1857551172Want to grow your business with YouTube? It's a great option! Learn my strategy here: https://creatorfasttrack.com/workshop-registrationFREE Resources to Grow Your Online Business:The $100K Method Podcast Series: https://www.gillianperkins.com/the-100k-methodGrab our free course, Small Business 101: https://www.gillianperkins.com/small-business-101-free-opt-inWrite a Profit Plan for Your Business : http://gillianperkins.com/free-profit-plan Want to quit your job in the next 6-18 months with passive income from selling digital products online? Check out Startup Society.Have you already started your business, but it isn't generating consistent income? Schedule a free, 30-minute strategy session with our team to get unstuck!Work with Gillian Perkins:Apply for $100K Mastermind: https://gillianperkins.com/100k-mastermind Get your online biz started with Startup Society: https://startupsociety.com Learn more about Gillian: https://gillianperkins.com Instagram: @GillianZPerkins
In this heartfelt episode of Paige's Pod, Paige sits down with Laurie Roberts, founder of Larry Roberts Chicago, to talk about love, loss, creativity, and what it means to carry someone's legacy forward through art. Laurie shares the cinematic “meet cute” of how she met her late husband, Larry Roberts - an artist who created from deep emotion, using painting as therapy and self-expression. We talk about the vulnerable (and very real) difficulty of selling work that feels like a piece of your soul, and how Laurie supported Larry through the behind-the-scenes business side while he stayed rooted in the creative process. Laurie opens up about Larry's acute myeloid leukemia (AML) diagnosis in 2017, his final series of paintings, and the early days of grief - when everything went off the market and she didn't yet know what came next. That “next” became a powerful new chapter: transforming Larry's artwork into heirloom-quality, hand-knotted rugs, textiles, and home pieces - crafted with artisans in India and built to last for generations.Together, Paige and Laurie talk about:The beauty (and challenge) of being a multi-passionate creativeWhy art and color can shift mood, support healing, and bring joy to everyday spacesTaking risks in business, pivoting when needed, and the truth about “overnight success”How creativity can support people through hard seasons - especially illness, caregiving, and griefLaurie's advice for anyone wanting to honor a loved one's artistic legacy in a meaningful wayThis conversation is tender, inspiring, and full of permission to keep creating - even when life breaks your heart. Connect with Laurie + explore Larry's work:Website: LarryRobertsChicago.comSocial: @LarryRobertsChicago (Instagram / YouTube / Facebook)
Maurice Roberts, who edited the Banner of Truth Magazine for many years, is noted for his poignant editorials. This one, from the December 1994 issue of the magazine, is typically probing and helpful. Are we battle-weary? Are we disappointed? Are we, dare we admit it, spiritually sleepy? If so, Rev. Roberts' article can help us see our need and seek the Lord for the grace of repentance and the gift of renewal. Featured Resource: – Maurice Roberts, 'Are You Battle-Weary?', Banner of Truth Magazine, Issue 375 (December 1994). Explore the work of the Banner of Truth: www.banneroftruth.org Subscribe to the Magazine (print/digital/both): www.banneroftruth.org/magazine Leave us your feedback or a testimony: www.speakpipe.com/magazinepodcast
Nicola Longo MD, PhD, and Mark Roberts, MDDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at WORLDSymposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.Nicola Longo MD, PhDWhat I want to do today, is just place gene replacement therapy within the current landscape of lysosomal storage disorder treatment therapy. Gene therapy obviously has the potential of treating lysosomal disorder to correct the root cause of lysosomal storage disorder. The gene is defective, and what happen is that you can potentially either fix the gene or bypass the lack of the genetic product. But there are already therapies that are existing and are functioning. Obviously, in many cases, the lysosomal disorder is caused by defective production of an enzyme, which is defective.We can either replace the enzyme with enzyme replacement therapy, or provide chaperone for specific mutations that retain the synthesis of the enzyme, that however is not very functional. Another avenue that it is being reported is the utilization of substrate reduction therapy. A substrate accumulates, you prevent the synthesis of the substrate to reduce the accumulation of toxic material. What we know now is that this is not enough to produce many lysosomal disorders. In many cases, the lysosomal disorder result sometime in impairment of intracellular trafficking, and sometime in the function of other organelles.At the end, it results in the activation of the macrophagic system and inflammation. Already we have some therapy acting at this level. The end result of lysosomal storage disorder, there will be cell suffering and cell death, leading to a progression of the disease, and morbidity and mortality. Now, what therapy do we have available already? Obviously, hematopoietic stem cell transplantation has been around for quite some time.It has been the same thing that we do with gene therapy, except that instead of reintroducing the gene of the subject, we place gene of a subject who is not affected of the disease. This therapy has been proven effective in cases of MPS-1 and alpha-mannosidosis. But in many cases this has to be given way before symptoms start to be affected.Enzyme replacement therapy has been around for quite some time, starting with Gaucher disease, and now that it is available for a list of diseases that are there, so it's like Fabry, Gaucher, Pompe, different types of mucopolysaccharidosis, alpha-mannosidosis, acid lipase deficiency, 1 neuronal ceroid lipofuscinosis, and Niemann-Pick type A and B.Obviously the advantage of this therapy, they give back the enzyme that it is defective. But the disadvantage that many time they cannot enter specialized areas such as the brain. There is already the second generation of enzyme replacement therapy that it is available. With this second generation, some of the newer drugs are more effective in terms of cellular uptake, or in terms of having a prolonged half-life and prolonged activity.Then there are pharmacological chaperone therapy, and the one which is FDA approved is migalastat for Fabry disease, under study is ambroxol for Gaucher disease. The disadvantage of this therapy that only a selected number of mutations respond to this therapy.Substrate reduction therapy has been introduced for Gaucher disease many years ago with miglustat, and it was followed by eliglustat. Both of them are effective, and some of them more effective than other, simply because of the fewer side effects of eliglustat as compared to miglustat. But at the same time, eliglustat does not pass the blood brain barrier.Finally, the newer agents that are already administered, N-acetyl-L-leucine and arimoclomol, both approved for Niemann-Pick type C, they act more on the downstream effect of the lysosomal storage disorder, either by stabilizing neuronal cell activity or by reducing the inflammation that is present in the brain.In the next part, Dr. Longo will discuss gene replacement therapy in lysosomal disorders.
Nicola Longo MD, PhD, and Mark Roberts, MD Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice.The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss vectors, different strategies, modes of administration and targets in gene replacement therapies.Mark Roberts, MDNow in the broader sense, gene replacement therapy seeks to actually deliver genetic material directly into the host cell to influence gene expression. In the most simple idea, one of course has a vector, this is most commonly but not exclusively a virus, which can then be given intravenously for example, and can hope to potentially correct the condition within the individual cells using novel transgenes. Suitable candidate conditions for this as examples of genetic conditions are now well understood. And crucially, this applies not only towards some more recessive, but dominant and even accident conditions.Across the piece, one can see for example, mitochondrial problems, spinal muscular atrophy as is well known, X-linked myotubular myopathy, Duchenne muscular dystrophy, a very common condition affecting one in 3000 male individuals, Pompe disease of course, an important focus of the meeting here, but other very common conditions, for example, cystic fibrosis, immunological conditions and perhaps obviously very crucial in early work on gene therapy, hemophilia.Let's now think about the approaches to gene therapy. One can seek to work at the DNA level and gene replacement. In essence, one is trying to put a new transgene through into the nucleus that will ultimately be transcribed and translated and produce the important functional protein that is lost. Gene editing which is a very exciting new technology or CRISPR technology actually seeks to actually modify in vivo the actual mutations that are responsible for the pathogenic production of abnormal proteins and correcting these and actually producing a more normalized protein.But of course there are also RNA approaches where one seeks to actually repair the mRNA transcripts copied from the mutated gene. For example, this may be a novel approach that could be extremely useful in myotonic dystrophy, a multisystem condition. When we talk about the viral vectors, predominantly we're talking about viruses. Those such as adenoviruses and AAV viruses which have the virtue of not integrating into the host genome or at least not in a large amount, and those which deliberately seek to integrate into host genome such as retroviral or lentiviral systems that may be particularly useful for ex vivo systems.There are of course other ways to get genetic payloads into the nucleus, various polymers, nanoparticles and even cell penetrating peptides. Nanoparticles in particular is certainly on the ascendant. That being said, in a recent review of the clinical trials in gene therapy, it was certainly the viral vectors that stood out both in direct gene replacement with lentivirus and AAV, but also actually as delivery systems, for example, for gene editing. An example of what one is seeking to do with AAV, so of course one seeking to remove the native DNA, insert the new transgene directly into the vector and of course keen to make sure that there's a high transmission into the capsid producing a recombinant AAV, which then can be given as a treatment and hopefully produce a therapeutic increase in the functional protein that is deficit in the disorder.In the next part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.
Chelsea show real fight as the Blues come from 2-0 down to draw 2-2 away at Newcastle on Saturday. Manny and Simon review a truly shocking first half, before an incredible second-half turnaround that showed resilience, leadership, and belief.The hosts highlight standout performances from Reece James, João Pedro, and Robert Sánchez, all of whom played huge roles in dragging Chelsea back into the game. They also dig into the big question — why did Chelsea start so poorly, and how were they able to recover so dramatically after the break?Finally, attention turns to another massive test, with a preview of next weekend's clash against high-flying Aston Villa, as Chelsea look to build on this hard-earned point.
TRUCKSTOP: The Disappearances of Caleb Smith & Keeslyn RobertsBecome a supporter of this podcast: https://www.spreaker.com/podcast/missing-persons-mysteries--5624803/support.
Why Dec. 25? Why so much Christmas conflict & controversy in Christianity's history? Why is Christmas so important to Christianity? And to America? In this episode, I ask my guest, Dr. Carey Roberts, the following questions: ►Why is Christmas such a grand celebration? What does this tell us about Christianity? ►Did it take a while for Christmas to take a central role in Christianity►What's the difference between recognition and celebration of Christmas►Did Christmas piggyback on existing Roman pagan traditions? ►How did Christmas enter America's culture? If not the Puritans, then which immigrant group introduced Christmas to America? ►Were there any regional differences in the celebration of Christmas?►When did U.S. businesses begin to capitalize on Christmas? ►Would President Grant have witnessed a similar Christmas celebration in Boston and Savannah? ►Would George Washington recognize our Christmas? How about Andrew Jackson? Abraham Lincoln? Teddy Roosevelt? ►What happened to Christmas after WWII? ►Is it a bad thing that non-Christians and/or non-practicing Christians celebrate Christmas?
Valenti and Rico started the show with their thoughts on what WFAN's Evan Roberts had to say about his confidence in the Knicks in a potential playoff series with the Pistons. They spent some time discussing why they all disagree with Roberts before they shifted to break down some recent comments from Kelvin Sheppard about his satisfaction with how his defense has played recently. The guys had an unconventional third hour, which included a Christmas movie draft and then ended the show with their disappointment with Michigan football's strict policy when it comes to asking its players about Sherrone Moore.
Scott interviews economist Bob Murphy about how the Federal Reserve enables the government to pursue its wars of choice. They also talk about the soundness of Modern Monetary Theory, the prospect of a war with Venezuela, the affordability crisis and more. Discussed on the show: The Creature from Jekyll Island by G. Edward Griffin What Has Government Done to Our Money? by Murray Rothbard Secrets of the Temple: How the Federal Reserve Runs the Country by William Greider Politically Incorrect Guide to the Great Depression and the New Deal by Robert P. Murphy Robert P. Murphy is a Senior Fellow with the Mises Institute. He is the author of numerous books: Contra Krugman: Smashing the Errors of America's Most Famous Keynesian; Chaos Theory; Lessons for the Young Economist; Choice: Cooperation, Enterprise, and Human Action; The Politically Incorrect Guide to Capitalism; Understanding Bitcoin (with Silas Barta), among others. He is also host of The Human Action Podcast and The Bob Murphy Show. Follow him on X @BobMurphyEcon Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow Learn more about your ad choices. Visit megaphone.fm/adchoices
(00:00-21:58) Doug knows The Weeknd. Jackson explains Tiger Nationalists. Burner accounts are the most courageous. Jackson wants to give proper context so we're gonna hear some audio. First up is Drink talking about trying to find a way to keep Jamal Roberts in Columbia. Next up is Ahmad Hardy talking about other teams not contacting him because they know he's a Tiger. And now audio from BK & Ferrario commenting on the Jamal Roberts/NIL situation saying Roberts should go look to get more carries elsewhere. Then the Tiger Nationalists came after them.(22:06-31:04) Light My Love. Josh Schertz will join us tomorrow. The Dish. SLU to the Big East would be a great thing. We will reconcile by winning.(31:14-33:10) Papers loves some CCR. Jackson's an old soul. The dichotomy of Papers. QFTA today.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Download Audio. Scott interviews economist Bob Murphy about how the Federal Reserve enables the government to pursue its wars of choice. They also talk about the soundness of Modern Monetary Theory, the prospect of a war with Venezuela, the affordability crisis and more. Discussed on the show: The Creature from Jekyll Island by G. Edward Griffin What Has Government Done to Our Money? by Murray Rothbard Secrets of the Temple: How the Federal Reserve Runs the Country by William Greider Politically Incorrect Guide to the Great Depression and the New Deal by Robert P. Murphy Robert P. Murphy is a Senior Fellow with the Mises Institute. He is the author of numerous books: Contra Krugman: Smashing the Errors of America's Most Famous Keynesian; Chaos Theory; Lessons for the Young Economist; Choice: Cooperation, Enterprise, and Human Action; The Politically Incorrect Guide to Capitalism; Understanding Bitcoin (with Silas Barta), among others. He is also host of The Human Action Podcast and The Bob Murphy Show. Follow him on X @BobMurphyEcon Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow
Virginia Roberts is battling it out in court with someone known as Jane doe # 133. The battle has to do with Jane Doe's persistent resistance to her name being unsealed as part of the document dump initiated by Judge Preska. Virginia Roberts and her legal team say that transparency and the publics right to know outweighs Jane doe's right to privacy, considering she has already been named in public. Now it will be up to the court to decide.to contact me:bobbycapucci@protonmail.comsource:Jeffrey Epstein Victim Virginia Giuffre Fighting Jane Doe's Objection to Unsealing of Records (radaronline.com)
Mark Thornton of the Mises Institute joins the show to talk about the state of the economy, the boom bust cycle and why anybody—left, right, and center—who cares about the wellbeing of the working class needs to oppose the existence of the Federal Reserve. Discussed on the show: “The Seven Deadly Economic Sins” (Mises.org) The Minor Issues Podcast Mark Thornton is a senior fellow at the Mises Institute. His most recent book is The Skyscraper Curse: And How Austrian Economists Predicted Every Major Economic Crisis of the Last Century. Follow him on Twitter @DrMarkThornton Audio cleaned up with the Podsworth app: https://podsworth.com Use code HORTON50 for 50% off your first order at Podsworth.com to clean up your voice recordings, sound like a pro, and also support the Scott Horton Show! For more on Scott's work: Check out The Libertarian Institute: https://www.libertarianinstitute.org Check out Scott's other show, Provoked, with Darryl Cooper https://youtube.com/@Provoked_Show Read Scott's books: Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine https://amzn.to/47jMtg7 (The audiobook of Provoked is being published in sections at https://scotthortonshow.com) Enough Already: Time to End the War on Terrorism: https://amzn.to/3tgMCdw Fool's Errand: Time to End the War in Afghanistan https://amzn.to/3HRufs0 Follow Scott on X @scotthortonshow And check out Scott's full interview archives: https://scotthorton.org/all-interviews This episode of the Scott Horton Show is sponsored by: Roberts and Roberts Brokerage Incorporated https://rrbi.co Moon Does Artisan Coffee https://scotthorton.org/coffee; Tom Woods' Liberty Classroom https://www.libertyclassroom.com/dap/a/?a=1616 and Dissident Media https://dissidentmedia.com You can also support Scott's work by making a one-time or recurring donation at https://scotthorton.org/donate/https://scotthortonshow.com or https://patreon.com/scotthortonshow Learn more about your ad choices. Visit megaphone.fm/adchoices