Podcasts about nk cell

Trigger Warning - This episode contains discussion surrounding Pregnancy loss. If today is not a good day, please come back to this episode when you're feeling a little stronger. Here at The Fertility podcast, we're always here for you.We're delighted that this week's episode is sponsored by The Lowdown - the place to get the lowdown on your reproductive health. Learn about your fertility share your experiences and read those of others.In this week's episode of The Fertility Podcast, I am joined by a patient of mine - Katie. Katie @secondary_infertility_life shares her story of secondary infertility, IVF and pregnancy loss.Katie knows that she is really lucky to have her little boy Jake. Jake is everything to Katie and more, however she just feels that, as yet, her family is not complete. However Katie found the process of trying to conceive again really isolating. Somehow it just felt harder to find support when you already have a child. I firmly believe that trying to conceive the second (or third, or fourth) time around is different as not only do you want a baby for yourselves but you desperately want a sibling for your existing child. So that they don't grow up alone in life. This is exactly how Katie felt.After trying unsuccessfully for a year or so, Katie and her husband finally found out that they were pregnant. Fantastic news! However, Katie could tell something wasn't quite right with the pregnancy, and sadly at 8 weeks they went for a scan and there was no heartbeat. Katie ended up miscarrying at home and she talks about how she felt OK physically, but took time for her to heal emotionally.After trying for another 6 months, Katie and her partner decided to start IVF. Katie had a top grade frozen embryo transfer in November last year and got a positive pregnancy test. Sadly, at Christmas, there was no heartbeat again and Katie had a miscarriage in the hospital. Katie talks about her positive experience of miscarrying at the hospital and how she got all the support she needed.Katie went for her 3rd transfer, which was sadly unsuccessful again and by this point Katie says she knew something else was wrong. She wanted to find out more and made the decision to have NK Cell testing. This identified a high level of natural killer cells which has informed her treatment going forward. At the time of recording Katie was about to embark on her next round of treatment and I'm sure you'll all join me in wishing her the very best. We're hoping this is the one Katie!Katie's advice to listeners is to trust yourself and your gut, to keep driving and find out what further investigations are out there for you and get knowledgeable. Make your own decision on what's best for you and you alone.Socials:Follow @TheFertilityPodcast on InstagramFollow @your_fertility_nurse on InstagramFollow @secondary_infertility_life on InstagramFollow @get.the.lowdown on Instagram

References Journal of Hepatology 2012 56, 704-713DOI Eur J Immunol. 2019 Jan;49(1):38-41 Front Immunol. 2016; 7: 19. Immun Ageing. 2020; 17: 16. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8913–8918. Cells. 2021 Jun; 10(6): 1332 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Front Immunol. 2018; 9: 476 Nature Reviews Gastroenterology & Hepatology 2023. 20: 662–678 (2023) Cells. 2021 Jun; 10(6): 1332. Traffic, (Traditional. arr. S Winwood )1970. "John Barleycorn Must Die" https://youtu.be/icyPFsIcAV0?si=XSVxsiojZBrwGPx6 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Front Immunol. 2023; 14: 1151166. Inflammation Research :official journal of the European Histamine Research Society 2018.1420-908X, Vol. 67, Issue 10. J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. Hunter, R. and J. Garcia 1970. "Sugaree" https://music.youtube.com/watch?v=sxF9UJ-Rm0E&si=S4F0LvlFvUsTE1OO --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Front Immunol. 2023; 14: 1151166 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Cancers 2020, 12(4),952 JBC. 2018. 293: 2422-2437. J Immunother Cancer. 2021 Nov;9(11):e003675 Front Oncol. 2023 May 18:13:1145667 Front. Immunol.2019. Sec. Cancer Immunity and Immunotherapy Volume 10 Int. J. Mol. Sci. 2019, 20(3), 646 Front Immunol. 2019; 10: 14 Vivaldi, A. 1716. RV589 Gloria https://youtu.be/2eWjQOdYzMQ?si=dpZaNZilqPXi6fJU --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Immunity. 2018 Oct 16;49(4):695-708 Front Immunol. 2019; 10: 14 Front. Immunol., 24 July 2017 Vol 8. Sec. T Cell Biology --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapies as well as the ethical considerations around them.

In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapies as well as the ethical considerations around them.

In this episode of Talking Techniques, Ritwika Biswas, Field Scientist at Sino Biological US Inc. (PA, USA), walks us through the chimeric antigen receptor (CAR) development process and how T and natural killer (NK) cells can be utilized to carry these modular synthetic molecules. Ritwika also addresses the safety and efficacy of these cell therapies as well as the ethical considerations around them. Hosted on Acast. See acast.com/privacy for more information.

References Authentic Biochemistry Podcast Immunoepigenetics lectures XXIX-XXX1 Dr. Guerra's intermediary metabolism and bioenergetics lectures Nature. 2019 Jul; 571(7765): 403–407 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

In this week's episode, we'll discuss involvement of IL-13 and IL-4 signaling in fibrotic progression of myelofibrosis; next, we review results on a novel agent using vWF-dependent mechanisms to lyse pathological thrombi in acute ischemic stroke. Finally, we'll shed new light on findings that implicate the GARP-TGF-beta-1 pathway in the loss of natural killer cell cytotoxicity in relapsed AML.

ในร่างกายของคนเรา มีเซลล์ต่างๆ มากมายหลายร้อยชนิด โดยแต่ละชนิดต่างมีหน้าที่ต่างๆ สำหรับในการดูแลร่างกายแตกต่างกันออกไป แต่น้อยคนที่จะรู้จักและรู้ถึงความสำคัญ ของเซลล์ที่มีชื่อว่า NK Cell ที่อาจจะเป็นกุญแจสำคัญ ที่จะทำให้เรานั้นสามารถตรวจความเสี่ยงของ “โรคมะเร็ง” ได้อย่างแม่นยำเลยทีเดียว . ซึ่งในวันนี้เราสามารถนำ NK Cell มาใช้ ในการพัฒนา นวัตกรรมการตรวจสุขภาพ ที่ตรวจได้ลึกถึงระดับศักยภาพการทำงานของเซลล์เม็ดขาว หรือที่เรียกว่า NK Cell Activity Test ที่สามารถบอกได้ว่าเรามีความเสี่ยง ในการเป็นโรคร้ายต่างๆ มากน้อยแค่ไหน โดยเฉพาะ โรคมะเร็ง . โดยใน Mission To The Moon EP. นี้เราจะไปพูดคุยกับ นายแพทย์ วีระพล เขมะรังสรรค์ ผู้ก่อตั้งและ CEO ของ MEDEZE Group และ MEDEZE NK บริษัทในเครือ สถาบันฝากเก็บเซลล์แห่งแรกและแห่งเดียวในไทย ที่จะมาคอยให้ความรู้และตอบคำถามเหล่านี้ให้พวกเรา . Mission To The Moon x MEDEZE

ในร่างกายของคนเรา มีเซลล์ต่างๆ มากมายหลายร้อยชนิด โดยแต่ละชนิดต่างมีหน้าที่ต่างๆ สำหรับในการดูแลร่างกายแตกต่างกันออกไป แต่น้อยคนที่จะรู้จักและรู้ถึงความสำคัญ ของเซลล์ที่มีชื่อว่า NK Cell ที่อาจจะเป็นกุญแจสำคัญ ที่จะทำให้เรานั้นสามารถตรวจความเสี่ยงของ “โรคมะเร็ง” ได้อย่างแม่นยำเลยทีเดียว . ซึ่งในวันนี้เราสามารถนำ NK Cell มาใช้ ในการพัฒนา นวัตกรรมการตรวจสุขภาพ ที่ตรวจได้ลึกถึงระดับศักยภาพการทำงานของเซลล์เม็ดขาว หรือที่เรียกว่า NK Cell Activity Test ที่สามารถบอกได้ว่าเรามีความเสี่ยง ในการเป็นโรคร้ายต่างๆ มากน้อยแค่ไหน โดยเฉพาะ โรคมะเร็ง . โดยใน Mission To The Moon EP. นี้เราจะไปพูดคุยกับ นายแพทย์ วีระพล เขมะรังสรรค์ ผู้ก่อตั้งและ CEO ของ MEDEZE Group และ MEDEZE NK บริษัทในเครือ สถาบันฝากเก็บเซลล์แห่งแรกและแห่งเดียวในไทย ที่จะมาคอยให้ความรู้และตอบคำถามเหล่านี้ให้พวกเรา . Mission To The Moon x MEDEZE

references Am J Physiol Regul Integr Comp Physiol2018. 314: R909–R915. Obesity (Silver Spring). 2008 Jun; 16(6): 1284–1288 Front. Immunol., 26 April 2019 Sec. NK and Innate Lymphoid Cell Biology Journal of Biological Chemistry 2018. 293: 2422-2437 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Virginia Li digs into more promising data for NK CAR cell therapy, this time from Nkarta who share price doubled on the announcement. We listen to an extract from this week's KOL View Live discussion between Michael Flanagan and Xianxin Hua, professor of cancer biology at the University of Pennsylvania's Perelman School of Medicine, about the progress of CAR-T therapies as potential treatments for solid tumours. And Simon King provides some early thoughts on key trends from first quarter earnings season, including uncertainty around future COVID-19-related revenues and Big Pharma's appetite for M&A.

Shoreline Biosciences  CEO Kleanthis Xanthopoulos, Ph.D. joins the Business of Biotech to share the company's strategy for the development, manufacture, and commercialization of off-the-shelf NK (natural killer) cell therapy. On this episode,  Dr. Xanthopoulos shares why the cell and gene immunotherapeutic market has underperformed to date, why he believes autologous is not the long-term path forward, and  the safety and accessibility advantages he sees in his allogeneic-based, pluripotent stem cell approach. Visit www.bioprocessonline.com to learn how another emerging biopharma is leveraging allogeneic NK cells in oncology. 

A fascinating new study found correlations with NK Cell activity, vitamin D status and exercise habits. Since NK cells are a vitally important first-line defense against pathogens, these findings have timely, real-world implications. Support your Vitamin D levels this Fall and Winter with Essential Fatty Nutrients by MYOXCIENCE Nutrition: http://bit.ly/vitamin-d-k-2-blend Save with code: Podcast Grab the blood work cheat-sheet: https://bit.ly/3dyy4zM Link to Show Notes: https://bit.ly/3E4VU1Z Time Stamps: 0:00 Intro 01:15 Your adaptive immune system provides immunologic memory. 01:40 Natural killer cells are part of your innate immune system, which has no memory and provides an all or nothing response. 01:50 Increased expression of innate immune system activation is found with obesity, insulin resistance, hypertension, and other chronic inflammatory diseases. 02:55 Overweight individuals tend to have a higher viral load. 03:10 Natural killer cells deal with pathogens, bacteria, and viruses and cytokines released by natural killer cells, help to signal your adaptive immune system. 04:00 Natural killer cells are important in preventing cancer. 04:15 Vitamin D and exercise are major determinants of natural killer cell activity. 04:40 Age, gender, vitamin D and exercise are associated with immune function determined by natural killer cell activity. 04:45 Age was a determining factor for low natural killer cell activity in men, but not women. 05:10 Sufficient levels of vitamin D reduced risk of low natural killer cell activity in men. 05:30 Exercise reduced risk of low natural killer cells in women and in both men and women over the age of 60. 05:45 A natural killer cell assay is not commercially available here in the US. 07:30 Decreased natural killer cell function in immunologically normal elderly is associated with increased risk for severe infections and mortality in general. 07:40 Natural killer cells may play a critical role in the early immune response. 08:20 An exhausted innate immune system can become depleted with a severe infection. 10:20 Medium to high intensity exercise decreased the risk for very low natural killer cell activity in women. 11:50 The vitamin D level sweet spot appears to be between 40 and 60 nanograms/ml. 13:25 Low natural killer cell activity in women did not seem be impacted by age as much as with men. 13:55 The size of your thymus gland and the amount of T cells that you produce decline (immunosenescence) as you age. Natural killer cells may compensate for this. 14:40 Over-exercise is associated with greater odds of low natural killer cell activity. 15:30 Vitamin D deficiency and insufficiency were associated with increased susceptibility to COVID-19 17:00 Immune system assays are expensive. You can triangulate looking at things like white blood cell count, C-reactive protein. 20:45 Each 1 unit increase in BMI, reflected a 12% increase in the risk for severe COVID-19.  

GT Biopharma Inc (NASDAQ:GTBP) uplisted to NASDAQ on Feb 15th, 2021, with a $50 million valuation. Now, the stock is trading at over $500 million just half a year later. So what has caused the huge excitement in the sometimes speculative biotech sector? GT Biopharma is doing what no one else can do and has developed the […]

Dr. Caligiuri describes his journey from being a liberal arts major at a college in upstate New York, to being a Stanford trained MD, to his current position as President of City of Hope National Medical Center. Along the way Caligiuri shares his thoughts on training to be a hematologist in the late ‘80s – at a time when there were no curative therapies, and such a calling was daunting at best – to his finding a cherished mentor that put him on the road to becoming one of the top NK cell experts in the world.

Paul Hastings, CEO of Nkarta Therapeutics discusses results from their NKX101 study, an allogeneic CAR Natural Killer (NK) cell therapy, in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (MDS). Paul is the President and Chief Executive Officer of Nkarta, a privately-held biopharmaceutical company developing engineered natural killer (NK) cell therapies to treat cancer. After beginning his career in sales and marketing at Hoffman-LaRoche, he has led more than a dozen biopharma companies as CEO, President or Director. He currently serves as Vice Chair and member of the Executive Committee of BIO.

UXH4 ปลุกภูมิต้านทานสู้ COVID-19 ด้วย NK Cell ทำไมเราต้องคาดหวังวัคซีนด้วย? ในเมื่อร่างกายของเรานั้นสามารถสร้าง"วัคซีน" ธรรมชาติที่เรียกว่า"ภูมิคุ้มกันตัวเอง" ขึ้นมาสู้ไวรัสได้ เพื่อป้องกัน Covid รอบใหม่ ที่ไม่แสดงอาการถึง 90% .... ฟิวอยากชวนทุกคนที่สนใจมาทำความเข้าใจ"เซลล์เพชฌฆาต" (NKCell) ภูมิคุ้มกันที่มีมาตั้งแต่กำเนิดทุกคนกันครับ ! ช่องทางการติดตาม UXHealth . Apple Podcast https://apple.co/2yXeD2Q Sportify https://spoti.fi/3g0IBDJ Youtube : https://bit.ly/3m7FKur Facebook : https://www.facebook.com/uxhealth สามารถแนะนำติชม Podcast ได้ที่ https://bit.ly/2JNVGF2 . #UXHealth #สุขภาพเรื่องง่าย #TheEasyHealth

This week on the podcast Agustin discusses how to deal with failures in biotech investing, highlights the recent readouts at ASH, and shares a premium cell therapy pick of the week that is trading at a discount. Make sure to like, comment, subscribe and follow me on Twitter and TikTok @biotech_bros

สังกัดศูนย์ Line@atomybee โดยล๊อคอินเข้าระบบ กดออฟฟิศของฉัน เลือกแก้ไขข้อมูล กดเลือกศูนย์H080 Bangna Happiness Center แล้วกดแก้ไขที่มุมขวาล่าง หรือโทร 0878152531

First recorded at the 4th annual IO Combinations 360° conference, this talk provided by Dr Kenneth Hance, GSK addresses agonistic strategies, T and NK cell redirection and the use of genetic/phenotypic assocations to identify novel target space in IO. To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

� Jennifer…came to see me three months ago. She was suffering from severe abdominal pain and nausea. She was extremely jaundiced; even the whites of her eyes were yellow. She came asking me about her pancreatic cancer and what I could do about it. As she looked half dead sitting in my office, there was little I could suggest. First of all, I do not treat cancer. I explained that to her, then I tried to review everything she had done up to the present, what doctors she had seen, imaging performed, therapies undertaken, etc. It was hard to sit there and talk to her and not be alarmed at her appearance. The word cachexia comes to mind (emaciation, wasting away). She said she was through with all medical intervention and they had sent her home to die. All I could do was to offer some nutritional support to help ease her pain and suffering. I explained when stem cell mutate they produce an enzyme called malignanin which eats healthy tissue. Her own pancreas produces an enzyme called trypsin that STOPS malignin and another enzyme, chymotrypsin, liquefies the tumor, and her own excretion pathways would get the toxic dead debris out of her. I explained how we had made a product that had these enzymes in it and a lot of rebuilding and supporting herbs for the pancreas, since her own pancreas was obviously not working well and producing these enzymes! She purchased a bottle of our Longlife Energy Enzymes and left. I did not hear from her after that as I supposed she had passed on. She came back into the office a week ago all aglow and excited to be feeling so well. The cachexia was gone. The jaundice was gone. Her eyes were not yellow anymore, but bright white. The energy was back. She was thrilled to show us how well she was doing. The only thing she had started doing that was different from before was our enzymes. Nothing else. NO medical intervention. Mary and I are the creators of this supplement and even we were stunned. Jennifer purchased four more bottles, thanked us profusely, and left. Wow ... our entire staff were shocked at what we saw. What really caught my eye with this startling revelation in the visage of Jennifer, is that it so clearly played upon my own fears regarding the explosion of cancer in this country over the last several decades, especially since Nixon declared war on cancer during his administration. Wouldn’t YOU want to know about LEE Enzymes if your mother got cancer?  How many of us fear getting cancer? Breast cancer is supposed to befall 1 in 7 women now, 1 in 8 two years ago. Prostate cancer gets all men eventually if they live long enough. Are these numbers true? I hope they are not but I feel they are. Though, it doesn’t really matter when it strikes your family, does it? I see the same thing happening in other areas of our lives. This pattern of big government getting on board on some great crusade … the war on cancer, the war on drugs, the war on poverty, the war on AIDS, the war on terror, there is even J. Edgar Hoover’s war on crime back in the 1930’s. With all these losing wars we have lost the soul of war itself with all these silly metaphors for something truly horrible in and of itself, war. But these patterns continue to emerge when some new government backed “war” is used by the various industry combines and complexes to double down on the fear of our people and use their wars for profit and gain. Jennifer makes me think of the war on cancer that we are losing everyday. We are still looking in the wrong places…right now the big push is in the area of immunotherapy…build the immune response of the body’s natural defenses to seek out and kill cancer cells. Sounds good enough on the surface, but the body’s immune system, in the guise of the natural killer cell, the NK Cell, is already supposed to be doing that. Why are the natural killer cells, and powerful enzymes like Trypsin and Chymotrypsin, in cancer patients AWOL?  I think part of what makes us human is trying to solve the great dilemmas in our history on this planet, while trying to make sense of why we are here, and the same time, not lose our sense of mystery, novelty, and the unknown. We see great civilizations come and go…the Babylonian Empire, then the Medio-Persian Empire, then the Grecian Empire, the Roman Empire, I could go on, but what came before the Babylonians? They came out of nowhere with little if anything, to suggest any empire preceded theirs, and yet they had immense buildings, powerful armies, huge agricultural developments, and artistic relics that today are priceless. All these empires had doctors and healers, magi and spiritualists, and their surviving records all show the same pattern…food was their medicine, and a sick gut was the cause of their diseases. These were the ruling masses in their day on this planet, and yet with such overwhelming power that they would wield over their subjects; they still used the gentlest of all healing modalities, food, for their medicine. ** It is in their records, their writings, their art, and their antiquities. Some of us make fun of their approach to healing and regeneration as being primitive or backward, and yet their own records testify it was to the effectiveness of a nutritional approach to health as being the only way that worked.  ** Here is an example of NOT having gentleness with healing:   “________ can lower your ability to fight infections, including tuberculosis. Serious, sometimes fatal infections, and cancer’s, including lymphoma, have happened, as have blood, liver and nervous system problems. Serious allergic reactions and new or worsening heart failure. (!!!) It works by targeting and helping to block a specific source of inflammation that contributes to both joint and skin symptoms. (!!!) It’s proven to help relieve pain. Doctor’s have been prescribing ________ for 10 years.” Like, that makes it okay.  David Wolf says, “It is no secret anymore that Big Pharma is (and has been) at war with alternative medicine. Its modus operandi is to generate profit by selling drugs that perpetuate a cycle of addiction and dependency, rather than liberation and empowerment.”  So what draws us to an alternate approach to health and healing? We can see with our own eyes when something works and when it does not. Mary and I have seen the marvelous advances in brain surgery with the experience of our own son whose life was saved by a crisis intervention using, anesthesia, emergency surgery by skilled surgeons and at the same time, during his recovery in the hospital over the next week, some of the most backward and essentially silly approaches to nutrition that would make any thinking person blush when the “nutrition center” in the hospital, featured such "modern nutrition" as slushy’s, ice cream, sugar sweetened cereals, commercial yogurts that are nothing more than soft ice cream, and other offerings that belong in the candy section of the gift shop, and not the nutrition center. Mary and I were stunned by what are eyes saw. So when we see marvelous changes happen in someone’s life, when we see people who are dying return to life, when we learn about a friend that chose a natural approach to their terminal disease and recovered and we hear their exultant voices and the cheers of their families, we know there is something more to health and healing other than drugs and surgery. We can see it, we can hear it, we can smell it, we can touch it, and we just know it there is a power inside our bodies that transcends all descriptions and understanding. This is the Forbidden Doctor. The one inside you that uses all its resources to keep you alive and well. But it needs help. It needs you to understand and listen to your own senses and listen to what your body wants. It isn’t easy believing something outside the majority whim. It never is, until or unless you experience something that changes your whole perspective of the meaning of anything. Health, politics, money, war, sex, teenagers… but when your eyes are opened to a new idea, a new construct, a new paradigm, it’s "Katie Bar the Door!” Nothing can stop you but yourself. You are willing at that point to go and sell all you have to take a chance on this new idea, this new insight. [Lierre Keith] So we like this idea, and we dislike the other one. We believe this doctor, but we can’t believe the other one anymore. We have certain cultural trainings that limit what we can accept, even in the face of undeniable truth. What makes us believe what we believe? Especially the things we have never studied, researched, read a book about, discussed with opposing views, etc.? Why do we believe, sometimes, things that others believe to be utter nonsense? Because our value is at stake. Our value is tied to our image of perfection. This goes to the core of our being. We will be “right” at all costs, even going to war, and losing our sons to prove it. I suppose this is all a part of being human, but let me ask you this…why is the American public spending more and more money for their health care, outside of the mainstream medical arena? Why is alternative health care getting more of the American dollar than modern medicine, every year for the past decade? Why do we see a proliferation of health food and vitamin stores springing up everywhere? Because, obviously, they work. People are awakening to the failure of the medical model of "drugs for anything, drugs for everything"…. because an awakened public is coming to the one truth that has straddled all of man’s history, with empires and primitive tribes alike … food has always been your best medicine. And now with the devitalization of our commercial foods, the need for supplementation is greater then ever before. We have the ability as humans to have great belief and trust. What we have said in this podcast has probably, never been more relevant than it is now. Trust your body. Believe your heart. Your life depends on it. - Dr. Jack and Mary What You Will Hear: [00:01:15] Forbidden secrets of the week [00:04:45] Pancreatic cancer story [00:21:45] The body cures itself [00:23:10] Why do we keep seeing more kids that get cancer? [00:26:00] The short history of medicine [00:35:10] How to be the healer in your life [00:41:10] Drugs for everything, drugs for anything [00:48:05] You have to supplement to stay healthy Mentioned resources: Learn more about Ageless Thyroid and our LongLife Energy Enzymes To get access to our personalized symptom survey that will allow you to get a personalized list of supplements suited for you, please click here and we'll send you the login details to the survey. Podcast on the Mysterious Deaths of Holistic Doctors

Daniel Davis explains how the distribution of an inhibitory receptor on the surface of natural killer cells changes when an activating receptor is engaged.

The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors.

We aimed to investigate the natural killer (NK) cell activity in hGH-deficient adults and to analyze the effect of insulin-like growth factor (IGF)-I in uivo and in vitro on NK cell activity. NK cell activity was measured in a 4-h nonisotopic assay with europium-labeled and cryopreserved K-562 cells. NK-cell numbers were measured after incubation with murine monoclonal CD3 and CD16 antibodies by flow cytometry analysis. In a cross-sectional study, the basal and interferon- p (IFN-P) stimulated (1000 IU/ml) NK cell activity of 15 hGHdeficient patients and 15 age- and sex-matched controls was measured. The percentages and absolute numbers of CD3./16+ NK-cells were not significantly different in the patient vs. control group. The basal and IFN-P stimulated NK cell activity however was significantly decreased in the patient vs. control group at all effecter/target (E/T) cell ratios from 12.5-100 (e.g. 17 ? 3 vs. 28 ? 3% lysis without IFN-P, P < 0.05, and 42 t 4 vs. 57 2 4% lysis with IFN-0, P < 0.05; both at E/T 50). IGF-I levels of patients and controls showed a significant positive correlation with NK cell activity (r = 0.37; P < 0.05). In an IGF-I in vitro study (IGF-I in vitro 250-1250 kg/L), the basal and IFN-P stimulated NK cell activity of 13 hGH-deficient patients and of 18 normal subjects was significantly enhanced by IGF-I in vitro (e.g. GH-deficient patients: 9 ? 2 us. 10 2 2% lysis without IFN-P, P < 0.05 and 25 + 4 vs. 30 + 4% lysis with IFN-/3, P < 0.005; and normal subjects: 15 + 3 vs. 23 ? 3% lysis without IFN-/3, P < 0.001 and 35 2 4 us. 44 + 5% lysis with IFN-P, P < 0.001; both at IGF-I 500 pg/L). In summary, in our cross-sectional study, adult GH-deficient patients showed a significantly lower basal and IFN-P stimulated NK cell activity than matched controls, despite equal NK cell numbers. IGF-I levels of patients and controls showed a weak positive correlation with NK cell activity. In an in vitro study, IGF-I significantly enhanced basal and IFN-P stimulated NK cell activity of hGH-deficient patients and also of normal subjects. The decreased NK cell activity in GHdeficient patients may be caused at least in part by low serum IGF-I levels. IGF-I appears to be an independent coregulatory modulator of NK cell activity. (Endocrinology 137: 5332-5336, 1996)