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The Daily Drama Podcast with Steve Burton & Bradford Anderson
Get to know #GH's "Jacinda", Paige Herschell. From a three day gig to so much more, we talk to Paige about her journey to GH, her thriving musical career, and what she's looking forward to! Catch us this week in Myrtle Beach, Charlotte NC, and Greenville SC. Go to https://www.stonecoldandthejackal.com/tour for tickets! Watch This Episode on YouTube: https://youtu.be/fB-VE_jA2WQ Follow us on Facebook at: https://www.facebook.com/StoneColdandTheJackal/ Follow un on Instagram at https://www.instagram.com/stonecoldandthejackal/ Get even more on PATREON: https://www.patreon.com/stonecoldandthejackal
The Daily Drama Podcast with Steve Burton & Bradford Anderson
We visit with our good friend James Patrick Stuart! We talk about Valentin's latest return to #GH, James' move to the PNW, and of course...mustaches. Catch us next week in Myrtle Beach, Charlotte, and Greenville SC! Tickets at https://www.stonecoldandthejackal.com/tour Watch This Episode on YouTube: https://youtu.be/J-jTga3be8U Follow us on Facebook at: https://www.facebook.com/StoneColdandTheJackal/ Follow un on Instagram at https://www.instagram.com/stonecoldandthejackal/ Get even more on PATREON: https://www.patreon.com/stonecoldandthejackal
On episode 362 of the PC Update, Lulu speaks to Maxie like a toddler and it seems to have done the trick. Pretty sure Michael is banking on his relationship working out. Portia is about to return the favor. This episode covers GH episodes from March 9th - 13th, 2026 *Music provided by Scott Holmes (song name - Electronic Vibes).
Ghé thăm Hà Nội không chỉ trở thành một thông lệ vào mỗi dịp đầu năm của Have A Sip mà còn trở thành dịp để chúng tôi gặp lại một hoặc nhiều "khách quen". Năm nay, ngoài bác Trịnh Lữ, Have A Sip có dịp "tái ngộ" Nhà báo, Tác giả sách Đinh Đức Hoàng - hay còn biết đến với cái tên Hoàng Hối Hận.Quay trở lại Have A Sip cùng cuốn sách "Ảo ảnh trong xã hội dư thừa kết nối", anh chia sẻ về những trăn trở cá nhân xoay quanh cuộc khủng hoảng tuổi trung niên, bản chất các mối quan hệ xã hội trong kỷ nguyên số, và tương lai của nghề viết trong một thế giới đang thay đổi nhanh chóng.#HaveASip #Vietcetera #Vietcetera_Podcast #HAS249—Đừng quên có thể xem bản video của podcast này tại: YouTubeVà đọc những bài viết thú vị tại website: Vietcetera—Yêu thích tập podcast này, bạn có thể donate tại:● Patreon: https://www.patreon.com/vietcetera● Buy me a coffee: https://www.buymeacoffee.com/vietceteraNếu có bất cứ góp ý, phản hồi hay mong muốn hợp tác, bạn có thể gửi email về địa chỉ team@vietcetera.com
Welcome to this week's Midlife Minute. Many women have been asking why they wake up at 2, 3, or 4 am every night. So today, I'm breaking down 10 common reasons this happens. I've also included some research links in the show notes for those who want to learn more. Stay tuned as I unpack the key factors that disrupt women's sleep in midlife. IN THIS EPISODE, YOU WILL LEARN: Cortisol spikes and sleep disruptions Why caloric restriction and repeated fasting could stress the body and lead to an overactive sympathetic nervous system The link between declining progesterone and nighttime awakenings How chronic under-eating or over-exercising can disrupt sleep, recovery, and metabolic health Why estradiol fluctuations make it harder to stay asleep Alcohol and late-night sugar fragment sleep Hormonal changes during perimenopause/menopause and increased sleep apnea risk How inflammation, leaky gut, and disrupted neurotransmitter production contribute to early awakenings Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Research Links Progesterone for treatment of symptomatic menopausal women Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women [EMPLOYMENT OF THE ELDERLY PEOPLE IN THE EUROPEAN UNION AND UKRAINE: REALITIES, PROBLEMS AND PROSPECTS] Obesity and its implications on oncological urological surgery Metastatic phenotype is regulated by estrogen in thyroid cells Soy protein isolate increases urinary estrogens and the ratio of 2:16alpha-hydroxyestrone in men at high risk of prostate cancer NMR at pressures up to 90 GPa
- Tổng Bí thư Tô Lâm tới thăm và chủ trì buổi làm việc với Báo Nhân dân nhân kỷ niệm 75 năm ngày báo Nhân dân ra số đầu tiên.- Chủ trì Hội nghị trực tuyến về tình hình phát triển kinh tế bạc trên thế giới và thích ứng với chính sách, chiến lược của Việt Nam, Thủ tướng Phạm Minh Chính yêu cầu chuyển từ gánh nặng già hóa dân số sang cơ hội phát triển kinh tế.- Thông tuyến đường sắt Bắc – Nam qua cầu Ghềnh, Đồng Nai sau sự cố sà lan đâm hỏng cầu.- Chiến tranh giữa Iran với Israel và Mỹ bước sang ngày thứ 12 mà chưa có dấu hiệu ha nhiệt, chính phủ nhiều nước phương Tây đã đồng loạt Âu đóng cửa hoặc sơ tán đại sứ quán tại Iran.- Nhật Bản kỷ niệm 15 năm thảm họa kép thiên nhiên động đất - sóng thần khiến 22.230 người thiệt mạng và mất tích.
Hành trình xây dựng ĐƯỜNG SẮT CAO TỐC NHẬT BẢN - Việt Nam học hỏi được gì? | Thành NguyễnVideo này được chuyển thể từ bài viết gốc trên nền tảng mạng xã hội chia sẻ tri thức Spiderum
Đường sắt cao tốc Châu Âu: Cuộc đua của những “VIÊN ĐẠN THÉP” khổng lồ | Thành NguyễnVideo này được chuyển thể từ bài viết gốc trên nền tảng mạng xã hội chia sẻ tri thức Spiderum
Tìm hiểu thêm về công nghệ Hydrogen xanh và Power-to-X tại https://ptx-hub.org/______________Video này được chuyển thể từ bài viết gốc trên nền tảng mạng xã hội chia sẻ tri thức Spiderum
Video này được chuyển thể từ bài viết gốc trên nền tảng mạng xã hội chia sẻ tri thức Spiderum
Tất tần tật về lịch sử BUDWEISER: VUA BIA CỦA MỸ | Đức Thịnh | Thế GiớiVideo này được chuyển thể từ bài viết gốc trên nền tảng mạng xã hội chia sẻ tri thức Spiderum
TÓM TẮT TOÀN BỘ cuộc cách mạng Mỹ trong 36 phút | Trần Phan | Thế GiớiVideo này được chuyển thể từ bài viết gốc trên nền tảng mạng xã hội chia sẻ tri thức Spiderum
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital predictions indicate that Jordan's (Tanisha Harper) secret pregnancy comes to the forefront, potentially threatening her relationship with Curtis (Donnell Turner). GH predictions hint that Portia Robinson (Brook Kerr) is set for a shock when she discovers Jordan's secret. Spinelli (Bradford Anderson) and Maxie Jones (Kirsten Storms) face a rocky road ahead as Maxie's jealousy over Lulu Spencer (Alexa Havins) and Nathan's (Ryan Paevey) relationship threatens to derail their own. General Hospital spoilers show that Christina Corinthos-Davis (Kate Mansi) seeks the help of Jacinda Bracken (Paige Herschell), potentially offering her a job at the soon-to-be-reopened Charlie's Pub. In a surprising turn of events, Carly Corinthos Spencer (Laura Wright) and Valentine (James Patrick Stuart) share a bed, leaving Jason Morgan (Steve Burton) concerned for Carly's safety. And, GH spoilers reveal that Chase (Josh Swickard) and Brook Lynn Quartermaine (Amanda Setton) express their desire to foster Baby Jane Doe, hoping to start a family of their own. This episode was hosted by Belynda Gates-Turner for the #1 Soap Opera Channel, Soap Dirt. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ And Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
Tin tức tối 9-3: Đề nghị khởi tố vụ sà lan va chạm cầu Ghềnh gây thiệt hại vận tải khoảng 40 tỉ đồng; Cô gái bị người đàn ông kéo lê trên đường; Một du khách thoát chết khi tắm biển Cửa Lò; 12 bảo vệ Khu công nghệ cao TP.HCM hầu tòa...
The Daily Drama Podcast with Steve Burton & Bradford Anderson
On this week's episode we talk all things #GH. How fun was it to do a scene with Jane and Nancy? Is Jason really that bad of a parent for missing a call?? What could that tattoo possilby have meant? Come see us on the road! For tickets and info visit https://www.stonecoldandthejackal.com/tour To Watch This Episode on YouTube go to https://www.youtube.com/playlist?list=PL-9D3H05uD_yNRiUlrczErHDwUDor63dH
Śrī Caitanya Mahāprabhu every day would walk from Akrūra Ghāṭ in Vṛndāvana and sit down at Imlītala. It's preserved in a temple, and there's a little shrine outside where Caitanya Mahāprabhu used to sit under the tree and see the Jamunā. It's a celebrated place where you can remember Caitanya Mahāprabhu sitting and chanting, as it is mentioned in the śāstra that he would come there early in the morning—especially because many people came to see him at Akrūra Ghāṭ and he was besieged by the crowds, people wanting to just look at him and ask him questions. So, he would retreat to Imlītala, and there he would sit alone and see the beauty of the Jamunā River. It is said that he would chant into the late morning and early afternoon, just chanting japa. So that place is very special. We can remember how Caitanya Mahāprabhu is setting the example for all of us: how to relish Kṛṣṇa consciousness is taking time away from any other obligation to just sit and absorb the chanting of the Holy Names. There is nothing more effective than examining oneself and considering one's relationship with Kṛṣṇa by just chanting and hearing the name. We don't have to speculate. We can just suspend any doubts that we have and remember that God is a person; He has a name. His name is non-different from Him, and if we just chant sweetly and let it hit our ears without any expectation or any extra strain—and just be patient and consistent—then everything else will be done by Kṛṣṇa. After all, we're helpless and He's the Supreme Controller, so don't try to do anything extra other than what you can do, and everything will be okay. ------------------------------------------------------------ To connect with His Grace Vaiśeṣika Dāsa, please visit https://www.fanthespark.com/next-steps/ask-vaisesika-dasa/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 https://vaisesikadasayatra.blogspot.com/ ------------------------------------------------------------ Add to your wisdom literature collection: https://iskconsv.com/book-store/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 https://www.bbtacademic.com/books/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 https://thefourquestionsbook.com/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 ------------------------------------------------------------ Join us live on Facebook: https://www.facebook.com/FanTheSpark/ Podcasts: https://podcasts.apple.com/us/podcast/sound-bhakti/id1132423868 For the latest videos, subscribe https://www.youtube.com/@FanTheSpark For the latest in SoundCloud: https://soundcloud.com/fan-the-spark ------------------------------------------------------------ #makejapagreatagain #mantrameditation #chantharekrishnaandbehapy #spiritualawakening #soul #spiritualexperience #spiritualpurposeoflife #spiritualgrowthlessons #secretsofspirituality #vaisesikaprabhu #vaisesikadasa #vaisesikaprabhulectures #spirituality #bhaktiyoga #krishna #spiritualpurposeoflife #krishnaspirituality #spiritualusachannel #whybhaktiisimportant #whyspiritualityisimportant #vaisesika #spiritualconnection #thepowerofspiritualstudy #selfrealization #spirituallectures #spiritualstudy #spiritualquestions #spiritualquestionsanswered #trendingspiritualtopics #fanthespark #spiritualpowerofmeditation #spiritualteachersonyoutube #spiritualhabits #spiritualclarity #bhagavadgita #srimadbhagavatam #spiritualbeings #kttvg #keepthetranscendentalvibrationgoing #spiritualpurpose
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers show that Brennan (Charles Mesure) warns Josslyn Jacks (Eden McCoy) about the escalating danger around her, raising suspicions about Com's intentions. Charlotte Cassadine (Charlotte Cassadine) hits the jackpot when she overhears a potentially incriminating conversation. GH spoilers reveal that Sidwell (Carlo Rota) gives Willow Tait (Katelyn MacMullen) important directives, hinting at her pivotal role in Drew and his congressional seat. Maxie Jones (Kirsten Storms) lands in hot water when she overshares about a potential situation involving Lulu Spencer (Alexa Havins) and Nathan West (Ryan Paevey). More General Hospital spoilers indicate that Carly Corinthos Spencer (Laura Wright) and Valentine Cassadine (James Patrick Stuart) navigate their complicated relationship. Jason Morgan (Steve Burton) demands that Carly cut ties with Valentine, fearing for her safety. Meanwhile, Christina Corinthos-Davis (Kate Mansi) seeks Jacinda Bracken's (Paige Herschell) help, possibly in a bid to lure her away from Crimson. And, GH spoilers hint that Jordan Ashford (Tanisha Harper) potentially revealing a secret pregnancy, Elizabeth Baldwin (Rebecca Herbst) receiving surprising news from Dante Falconeri (Dominic Zamprogna), and Portia Robinson (Brook Kerr) receiving shocking news. With so many storylines intertwining, the residents of General Hospital are in for a week they won't easily forget. This episode was hosted by Belynda Gates-Turner for the #1 Soap Opera Channel, Soap Dirt. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ And Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
On episode 361 of the PC Update, Joss is out as a W. SELF-RIGHTEOUS. B. Sonny has gotten away with murder... committed by uncle Jason. Looks like Carly isn't the only one with an irrational obsession with Sonny. If joss didn't like Sonny, she sure won't like her next step daddy. This episode covers GH episodes from March 2nd - 6th, 2026 *Music provided by Scott Holmes (song name - Electronic Vibes).
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers reveal Willow Tait, played by Katelyn MacMullen, finds herself in control of Drew Cain, portrayed by Cameron Mathison. However, as spoilers suggest, this power dynamic won't last forever. Drew remains locked-in his body due to his current medical condition, but the tables are set to turn dramatically once he regains his faculties. GH spoilers indicate Willow has assumed Drew's seat in Congress, exercising control over his finances and their daughter. As the plot unfolds over the next few months, fans are anticipating a power flip. Drew, once recovered, is expected to retaliate against Willow for her role in his captivity. With potential criminal charges for drugging him and threats of separating her from her children, Drew could use these as leverage to maintain control over Willow's life. Spoilers for GH suggest that the potential of a baby between Drew and Willow could further tie Willow to Drew, resulting in an enduring revenge. Another potential move could be Drew forcing Willow to sever ties with her mother, Nina Reeves, played by Cynthia Watros, thus leaving her isolated and solely dependent on him. More GH spoilers hint that in addition to Nina, Drew might also demand Willow to cut off from other allies like Chase, played by Josh Swickard, and Liz Webber, portrayed by Rebecca Herbst. This could result in Willow losing all her relationships and being completely reliant on Drew, which is a thrilling twist to the ongoing drama of General Hospital. This episode was hosted by Belynda Gates-Turner for the #1 Soap Opera Channel, Soap Dirt. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
In this Port Charles 411: Fan Spotlight, Shannon and Amanda chat on Zoom with fellow General Hospital fan Melanie Samalon about her longtime love of the show and the storylines that made the biggest impact on her as a viewer. Like many fans who started watching in the 90s, Melanie was drawn in by Sonny and Brenda, and the conversation revisits why that era of GH remains so memorable. Melanie also shares a unique perspective as a trained actress who now works in corporate communications and dialect coaching. She talks about how her acting background shapes the way she watches soaps and why she appreciates the pace and craft of daytime television. The discussion covers favorite storylines and couples from the 90s, recasts, classic GH sets they'd love to see return, and even ideas for how the show could generate more revenue—from product placement to selling in-show items like Corinthos Coffee. It's a fun and nostalgic conversation between fans who share a deep appreciation for the world of Port Charles. Follow Melanie on Social Media https://www.instagram.com/sanmillanm Learn more about your ad choices. Visit megaphone.fm/adchoices
DOVVSU Circuit Court in Accra has granted Latifa Salifu, a suspect in the Mamprobi Clinic baby theft case, bail in the sum of GH¢200,000 with two sureties
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers for March 9-13, 2026 indicate Willow (Katelyn MacMullen)'s downfall and Britt (Kelly Thiebaud)'s meltdown take center stage. While at General Hospital, Josslyn Jacks (Eden McCoy) grows suspicious upon spotting Marco (Adrian Anchondo), who reveals his unsuccessful attempt to get Britt's meds. As Britt grapples with the stress of impending surgery and her father Faison's legacy, Ava Jerome (Maura West) misinterprets an invitation from Sidwell. Meanwhile, Carly Corinthos (Laura Wright) is stunned by something potentially involving her plan with Valentine. GH spoilers suggest a vulnerable side of Britt is seen by Elizabeth Webber (Rebecca Herbst), while Nathan (Ryan Paevey) and Lulu (Alexa Havins) share a close moment that is noticed by someone. Valentine Cassadine (James Patrick Stuart) asks Charlotte (Scarlett Fernandez) for patience as he works on a plan that might involve leaving Port Charles without the WSB on their tail. Curtis Ashford (Donnell Turner) is asked by Jordan (Tanisha Harper) if she wants him to move in with her, leading to a possible change in their living arrangements. Spoilers for General Hospital reveal Chase (Josh Swickard) and Brooklyn (Amanda Setton) devise a plan, Carly possibly hopes to sneak Valentine into a party at Windermere, and Lulu has a startling realization. Brennan expresses his frustration, likely to Jocelyn or Nina (Cynthia Watros), over Valentine's continued evasion. As the episode continues, Trina (Tabyana Ali) accepts an opportunity potentially involving her parents, and Nathan is blunt with his mother, Obrecht (Kathleen Gati), about his feelings for Lulu and Maxie (Kirsten Storms)'s choice of Spinelli (Bradford Anderson). More GH spoilers divulge Valentine and Carly reach a new understanding, Rick (Rick Hearst) expresses his desire for a future with Liz, Nathan and Lulu grow closer, and Jacinda opens up to Michael (Rory Gibson) about her past. As Drew (Cameron Mathison) faces a nightmare trapped by Willow and Sidwell, Portia (Brook Kerr) and Trina work to repair their bond. General Hospital spoilers hint Britt fears for her life without her medication, as Jason (Steve Burton)'s disappearance leaves her with only Lucas (Van Hansis) for support. Justine and Sonny (Maurice Benard) struggle with their attraction, while Obrecht continues to interfere in her son's life. Finally, Willow's downfall is imminent, setting the stage for dramatic episodes to come the week of 03/09 - 03/13/2026. The Soap Dirt podcast made the Top 100 List for Apple Podcast's Entertainment News Category. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers show that Curtis Ashford, portrayed by Donnell Turner, might be facing double paternity trouble. His ex-wife, Jordan Ashford, played by Tanisha Harper, could soon drop the bombshell that she's pregnant, potentially throwing his life into chaos. Meanwhile, Curtis's other ex-wife, Portia Robinson, portrayed by Brook Kerr, has moved on with Isaiah Gannon, played by Sawandi Wilson. Jordan's looming pregnancy news could complicate Curtis's life further, especially if there's a question mark hanging over the baby's true paternity. GH spoilers have shown that in the past Jordan concealed her affair with Shawn Butler, resulting in her son TJ Ashford, and may resort to similar deceit again. If the pregnancy news is confirmed, the timeline of Jordan's relationship with Curtis could be scrutinized. Any discrepancies might suggest that the baby might not belong to Curtis but to another man from Jordan's life – Brick, played by Stephen A. Smith. If the baby is indeed Brick's, it might prompt Jordan to lie, leading to a potential paternity plot twist that echoes her past misdeeds. More General Hospital spoilers indicate that as Curtis and Jordan navigate these tumultuous waters, Portia and Isaiah are moving forward in their relationship. However, Portia doesn't seem to want Curtis back, and Jordan's paranoia about a reunion between Curtis and Portia might push her to desperate measures. And, GH spoilers hint that Jordan, who has lied just as much as Portia, has been berating her for her past deceit. With the potential of a new baby on the horizon, Jordan's past and present could collides. This episode was hosted by Belynda Gates-Turner for the #1 Soap Opera Channel, Soap Dirt. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ And Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.
Season 63, Episodes 111-115, Spoiler Level MS (Medium Spoilers) Sidwell threatens everyone – Willow, Maxie, Lucas. Molly and Cody finally resolve their issues and there's kissing!! Jordan wears mom jeans and Stacy suggested someone (no idea who) be in a thruple. Kathy and Stacy are taking a brief hiatus and will return around March 22. Please continue to send your thoughts via socials, emails and/or commenting on the episode page. Comment and join the conversation with our other GH besties and regulars! Make friends. We will miss you but look forward to your comments during our respective vacations. Thank you for listening to our General Hospital podcast. If you enjoyed it, please subscribe and tell your friends. Drop us a review. And let us know your own musings and theories and fashion notes. Reach Stacy at Alexis@areweghing.com and Kathy at Felicia@areweghing.com. For more information, please visit us at www.areweghing.com Recorded 2-28-26, Music by Grammy award winning Alex Robinson (Her new album is out!!) https://www.musicbyalexrobinson.com/ Logo by the equally amazing Jakob Evans.
Send a textThis Episode of General Hospital Admittedly Fans! was recorded February 24th!If you have a question or would like to be a guest, drop us a DM on Instagram at @GHADMITTEDLYFANS simply email us Founder@swingmg.com.Malin, G and Jaim get into some wine and have strong emotions about the latest GH happenings, including our top storylines:Lucas and Marco's relationship on Danger IslandAlexis or Willow get a Congressional Nod!Maxie may be the key to uncovering who "Nathan" really isRick is EVERYONE's Favorite Performer.Enjoy our made up GH Spoilers and predictions, and peeves and props.Support the show
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers show that Curtis Ashford, portrayed by Donnell Turner, is seen reaching a final decision, possibly about officially divorcing. Portia Robinson, played by Brook Kerr, and Curtis have an intense meeting with their daughter Trina Robinson, played by Tabyana Ali, hinting at the possible officialization of their split. Meanwhile, Michael Corinthos, portrayed by Rory Gibson, opens up to Jacinda Bracken, stirring curiosity among fans. GH spoilers reveal that Chase and Brook Lynn Quartermaine, played by Josh Swickard and Amanda Setton respectively, uncover something alarming. Ned Ashton, played by Wally Kurth, talks to Chase about prioritizing his health. Elsewhere, Carly Corinthos, played by Laura Wright, scores big in her plot against Jack Brennan, adding a thrilling arc to the storyline. Weekly General Hospital spoilers indicate that Lulu Spencer, now played by Alexa Havins, is suspected of something by someone, hinting towards her mother Carly. On the other hand, Ava Jerome, portrayed by Maura West, makes a wrong assumption, possibly about Lucas Jones, played by Van Hansis. More weekly GH spoilers hint that Brennan, played by Charles Mesure, will show his frustration probably about the mess involving Anna Devane and others. Also, Britt Westbourne, played by Kelly Thiebaud, finds comfort from Jason Morgan, played by Steve Burton. This episode was hosted by Belynda Gates-Turner for Soap Dirt. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ And Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
On episode 360 of the PC Update, watch out Jenz because Willow has an AGENDA! No fuss no muss, an ex returning from the dead has never been handled so efficiently. Briefest coma draws the short stick! This episode covers GH episodes from February 23rd - 27th, 2026 *Music provided by Scott Holmes (song name - Electronic Vibes).
Send us a text if you want to be on the Podcast & explain why!A client came to me after being told she needed shoulder surgery.MRI showed a slight supraspinatus tear. No physical therapy was recommended. No movement assessment was performed. Just “you'll need surgery.”Instead of jumping to conclusions, we performed a full movement screen looking at the GH joint, scapula, thoracic spine and LPHC. No red flags were present. Several exercises were completely pain free. Others were only uncomfortable based on fear and guarding after being told she was “fragile.”This is where the biopsychosocial model of pain becomes critical for personal trainers.Pain is not always tissue damage. Language matters. Assessments matter. Understanding anatomy and movement matters.After helping her better understand what the MRI actually meant, how her shoulder moves, and which patterns felt safe to load, she avoided surgery and returned to training without pain.Knowing your scope as a personal trainer is important. But so is knowing when to assess, when to refer, and how to confidently work with clients who are in pain without making them feel broken.Textbook certifications like NASM ACE ISSA don't prepare you for real world scenarios like this.That's why we created the SUF-CPT and SUF-STM certifications.If you want to: • Assess clients in pain • Program on the fly • Partner with DPTs • Charge $150+ per session • Build confidence with real peopleYou have to SHOW UP.Learn more about our seminars and certifications here: [Insert Website]#PersonalTraining #Biopsychosocial #ShoulderPain #NASM #CPT #MovementAssessment #PainScience #ShowUpFitnessBecome a personal trainer, SUF CPT the fastest growing personal training certification for personal trainersWant to become a SUCCESSFUL personal trainer? SUF-CPT is the FASTEST growing personal training certification in the world! Want to ask us a question? Email info@showupfitness.com with the subject line PODCAST QUESTION to get your question answered live on the show! Website: https://www.showupfitness.com/Become a Successful Personal Trainer Book Vol. 2 (Amazon): https://a.co/d/1aoRnqANASM / ACE / ISSA study guide: https://www.showupfitness.com
A Table at the Tan-O: Conversations About the World of General Hospital
Wow! What a week in Port Charles! Brook Lynn did her best to get Chase to let go of his obsession with Willow (not sure it will work, but fingers crossed!). Lucas thinks he can keep himself safe and save Britt's life (not sure it will work, but fingers crossed!). Emma returned home from California and Gio couldn't have been happier (those two are really working!). Molly and Cody got back to a good place because Cody read some books (indoors Cody works just as well as outdoors Cody!). Dante and Elizabeth had a conversation at GH and there seemed to be a little spark (those two just might work!). And Willow and Sidwell are partners (could this actually work?)!!! #mauricebenard #kellythiebaud #rogerhowarth #maurawest #steveburton #delirious #barshampoo #daydrinkingwithsethmeyers #hillstreetblues #kinshriner #nicholaschavez #afterlife #rickygervais #hallandoates #superstore #freaksandgeeks #freefallin #alanarkin #newgirl #lamornemorris #colonoscopy #takethenap #alleymills #billylibby #chickadee #fortgorgeous #robertgossett #daydrinkingwithsethmeyers #marcuscoloma #useastaplegun #riptwitch #ripepiphany #ripsonyaeddy #waywardchickadee #barshampoo #ripmiffy #lovedogs #justinebateman #brookeshields #neilgaiman #dnice #cq #deborahcox #malcolmjamalwarner #lume #godzillaminusone #ripjacklynzeman #jasonmomoa #adambelanoff #thecloser #majorcrimes #wings #murphybrown #thecosbyshow #pinkalicious #ripbillymiller #ripmatthewperry #riptylerchristopher #riplesliecharleson #ripandrebraugher #ripjohnnywactor #dutchbarnvodka #chadduell #rickygervaisrobot #colinfromaccounts #ripanthonygeary
Tá turas á eagrú ag bean Ghúgán Barra do Ghaeilgeoirí chun tabhairt faoin gCamino.
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital 2-week spoilers for February 23-March 06, 2026 expect intense confrontations and unexpected revelations. Alexis Davis (Nancy Lee Grahn) will find herself incensed over an undisclosed matter while Drew Cain Quartermaine (Cameron Mathison) grows increasingly desperate. Wiley Quartermaine Corinthos (Viron Weaver) expresses his discomfort about staying at Drew's house, causing tension. GH spoilers reveal Damian Spinelli (Bradford Anderson) confides in Lulu Spencer (Alexa Havins) about his internal struggle over Maxie Jones (Kirsten Storms) and Nathan West (Ryan Paevey). Nathan and Maxie grapple with the shock of his miraculous awakening from the coma and share a heartfelt conversation at his grave. Spoilers for General Hospital suggest Ric Lansing (Rick Hearst), delivers news about Drew's case to Alexis, sparking a wave of disbelief about Harrison Chase's (Josh Swickard) involvement. Chase finds himself in hot water with Michael Corinthos (Rory Gibson) and Dante Falconeri (Dominic Zamprogna), culminating in a violent confrontation. GH spoilers hint Gio Palmieri (Giovanni Mazza) and Josh Swickard (Harrison Chase) discuss the fear of Emma Devane (Finola Hughes) not returning from San Francisco. As the tension escalates, Brook Lynn Quartermaine (Amanda Setton) has a tense conversation with Chase, signaling the end of her patience with the Willow Tait (Katelyn MacMullen) situation. More spoilers for General Hospital indicate Lulu Spencer (Alexa Havins) showing hesitation possibly towards Nathan, Lucas Jones (Van Hansis) receiving vital information, and Sonny Corinthos (Maurice Benard) confiding in his brother, Rick the weeks of 2/23- 3/06, 2026. This episode was hosted by Belynda Gates-Turner for Soap Dirt. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital predictions indicate that next week revolves around Maxie Jones, Cody Bell, Molly Lansing-Davis, Alexis Davis, and Willow Tait. GH predictions hint at intense interactions between Maxie (Kirsten Storms) and her love interests, Damian Spinelli (Bradford Anderson) and Nathan West (Ryan Paevey). Meanwhile, Cody (Josh Kelly) encourages Molly (currently played by Kristen Vaganos) to publish her book, and Alexis (Nancy Lee Grahn) might use her political savvy to blackmail Willow (Katelyn MacMullen) over a congressional seat. General Hospital spoilers show that Nathan, who's back from the dead after seven years, might express his feelings for Lulu Spencer (Alexa Havins) despite his past with Maxie, causing an emotional rollercoaster. GH spoilers reveal that Chase (Josh Swickard) could lose both his job and wife, Brook Lynn Quartermaine (Amanda Setton), due to his obsession with bringing Michael Corinthos (Rory Gibson) to justice. The Soap Dirt podcast has made the Top 100 List for Apple Podcasts in the Entertainment News Category. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ And Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers show that Michael Corinthos (Rory Gibson) is set to lose his temper with Harrison Chase (Josh Swickard), leading to a brawl in the Quartermaine kitchen. This altercation is likely due to Michael's belief that Chase has planted evidence against him, potentially threatening his freedom and access to his children. GH spoilers reveal that Josslyn Jacks (Eden McCoy) and Gio Palmieri (Giovanni Mazza) share concerns about Emma Devane (Finola Hughes), who has left for San Francisco. General Hospital spoilers indicate that Chase will tell Brook Lynn Quartermaine (Amanda Setton) that he did not plant evidence, though it remains to be seen if she will believe him. On another front, Wiley Quartermaine Corinthos (Viron Weaver) expresses his discomfort with living at Willow Tait's (Katelyn MacMullen) and Drew Cain Quartermaine's (Cameron Mathison) house, which could lead to a change in living arrangements. GH spoilers hint that Nathan West (Ryan Paevey) and Maxie Jones (Kirsten Storms) reconnect at the cemetery, leading to unresolved feelings resurfacing. Maxie's current partner, Damian Spinelli (Bradford Anderson), assumes that Maxie will choose Nathan over him and appears to be willing to step back. In other storylines, Dante Falconeri (Dominic Zamprogna) makes a promise, while Jordan Ashford (Tanisha Harper) issues a warning about Sidwell's (Carlo Rota) shady activities. You are listening to Belynda from Soap Dirt. The most listened to podcast for soap operas. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ And Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
On episode 359 of the PC Update, Lucas almost made contact with common sense then thought better of it. Turns out Wylie is the best the PCPD has to offer. It's Willow's house, Drew gave it to her... This episode covers GH episodes from February 16th - 20th, 2026 *Music provided by Scott Holmes (song name - Electronic Vibes).
Daily Soap Opera Spoilers by Soap Dirt (GH, Y&R, B&B, and DOOL)
Click to Subscribe: https://bit.ly/Youtube-Subscribe-SoapDirt General Hospital spoilers reveal characters Willow Tait (Katelyn MacMullen) and Harrison Chase (Josh Swickard) face the consequences of their actions, which might result in them leaving Port Charles together. Next week, Commissioner Dante Falconeri (Dominic Zamprogna) and DA Justin Turner uncover Chase's misconduct, albeit blaming him for the wrong reasons. Chase swiped Michael Corinthos's (Rory Gibson) keys to investigate into Drew Cain Quartermaine (Cameron Mathison)'s shooting, accidentally implicating Michael in the process. GH spoilers indicate Willow, meanwhile, is executing a plan to frame Michael for Drew's shooting, a plan that is ironically undermined by her own son, Wiley Quartermaine (Viron Weaver). As the evidence begins to pile against Chase, he faces the possibility of losing his job, his best friend Dante, and even his wife, Brook Lynn Quartermaine (Amanda Setton), who is upset with Chase's obsession with Willow. General Hospital rumors suggest that actor Josh Swickard, who plays Chase, may be leaving the show. Willow's fate is equally uncertain as her political ambitions could lead to her exposure. The Soap Dirt podcast made the Top 100 List for Apple Podcast's Entertainment News Category. Visit our General Hospital section of Soap Dirt: https://soapdirt.com/category/general-hospital/ Listen to our Podcasts: https://soapdirt.podbean.com/ Check out our always up-to-date General Hospital Spoilers page at: https://soapdirt.com/general-hospital-spoilers/ Check Out our Social Media... Twitter: https://twitter.com/SoapDirtTV Facebook: https://www.facebook.com/SoapDirt Pinterest: https://www.pinterest.com/soapdirt/ TikTok: https://www.tiktok.com/@soapdirt Instagram: https://www.instagram.com/soapdirt/
Chains and Strength: Women in Bengali LiteratureIn this podcast episode, Zakia Afrin and Nandini Ray of Maitri come together for a heartfelt conversation on the portrayal of women in Bengali literature. Drawing from their favorite short stories, novels, and poems from both Bangladesh and India, they explore how women characters have endured inequality and oppression while also embodying courage, resilience, and resistance to patriarchy.These unforgettable characters in Bengali literature has long mirrored women's struggles and celebrated their strength. Tune in, reflect with us, and join the conversation.What stories moved you? Which women characters have stayed with you?We'd love to hear from you, email us at maitri@maitri.org. এই পডকাস্ট পর্বে মৈত্রীর জাকিয়া আফরিন ও নন্দিনী রায় এক আন্তরিক আলাপচারিতায় একত্রিত হয়েছেন বাংলা সাহিত্যে নারীর উপস্থাপনাকে ঘিরে। বাংলাদেশ ও ভারতের ছোটগল্প, উপন্যাস ও কবিতা থেকে উদাহরণ টেনে তারা আলোচনা করেছেন—কীভাবে নারী চরিত্ররা বৈষম্য ও নিপীড়নের মুখোমুখি হয়েছে, আবার একই সঙ্গে সাহস, সহনশীলতা ও পিতৃতন্ত্রের বিরুদ্ধে প্রতিবাদের প্রতীক হয়ে উঠেছে।বাংলা সাহিত্যের এই অবিস্মরণীয় নারী চরিত্রগুলো দীর্ঘদিন ধরে নারীদের সংগ্রামের প্রতিচ্ছবি হয়ে আছে এবং তাদের শক্তিকে উদযাপন করেছে।আমাদের সঙ্গে শুনুন, ভাবুন, আর আলোচনায় যোগ দিন। কোন গল্পগুলো আপনাকে স্পর্শ করেছে? কোন নারী চরিত্রগুলো আপনার মনে স্থায়ী হয়ে আছে?আপনাদের মতামত জানাতে ইমেইল করুন: maitri@maitri.org।In conversation between:*Zakia Afrin, Director, Survivor Advocacy at Maitri is also Founder of Auditiya, a social and cultural platform promoting feminism, human rights and social Justice issues in Bangladesh and the diaspora. www.auditiya.com *Nandini Ray, Sr. Manager, Outreach, Prevention & Policy Advocacy and the host of the Maitri Podcast, Between Friends, Conversation with Maitri (https://www.youtube.com/playlist?list=PLAXam2z_Ro4JhXZqOQH7OyIjKDD1szHOb)Books we discussed: Streer Patra (The Wife's Letter) is a short story written by Rabindranath Tagore in 1914.Noshtoneer or Nashtanir, (The Broken Nest) is a 1901 Bengali novella written by Rabindranath Tagore.Ghôre Baire (At home and outside) is a 1916 novel by by Rabindranath Tagore Dahan, a novel by Suchitra Bhattacharya, published in 1996Draupadi, a short story by Mahasweta Devi was published in 1978 You can find All Tagore books here: https://archive.org/search?query=Tagore সুলতানার স্বপ্ন / Sultana's Dream (Performance by Auditiya at the Asian Art Museum, San Francisco)লাল সালু /Lal Shaluআমি বীরাঙ্গনা বলছি/ Ami Birangona Bolchi (Auditiya Interview on the English Translation, War Heroines Speak)আমি দ্রৌপদী/ Ami Droupodi
Hey Y'all! Join Toni and Nick as they break down the week in Port Charles. How will GH handle Jason's exit? Was addressing the relation between Charlotte and Dani worse than ignoring it? What is going on with Nathan? Tune in to find out!
Government has released GH¢855 million to settle arrears owed to cocoa farmers after a prolonged payment crisis that left many producers unpaid for months, despite delivering their produce to licensed buying companies.
Cocoa farmers in the Western North Region have staged a demonstration to protest the recent reduction in cocoa prices, from GH¢3,625 to GH¢2,587 per bag
Majority in Parliament has revealed that the government has released GH¢855 million to settle arrears owed to cocoa farmers, aiming to stabilize the sector and restore confidence. According to the Majority, this move is part of a broader reform package to put COCOBOD on a sustainable financial path.
COCOBOD owes farmers GH₵11 billion. How can it realistically pay them as directed by the Finance Minister, and where will the funds come from to settle this debt? - Fiifi Boafo, Former Head of Public Affairs, COCOBOD.
rWotD Episode 3212: Sikandar Khan Ghazi Welcome to random Wiki of the Day, your journey through Wikipedia's vast and varied content, one random article at a time.The random article for Wednesday, 18 February 2026, is Sikandar Khan Ghazi.Sikandar Khān Ghāzī (Persian: سکندر خان غازی, Bengali: সিকান্দার খান গাজী) was the first wazir of Srihat under the Lakhnauti Kingdom ruled by Shamsuddin Firuz Shah. Prior to this, Khan was one of the commanders of the Battles of Gour during the Conquest of Sylhet in 1303. Early Persian manuscripts and inscriptions relating to Shah Jalal name Sikandar Khan Ghazi as well, highlighting his role as a commander in the battles.This recording reflects the Wikipedia text as of 00:17 UTC on Wednesday, 18 February 2026.For the full current version of the article, see Sikandar Khan Ghazi on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Bluesky at @wikioftheday.com.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm standard Nicole.
The Daily Drama Podcast with Steve Burton & Bradford Anderson
We wanted to take a moment to wish you all a happy Valentine's Day and also address more rumors about Steve's decision to take a little break from #GH. Have a great rest of your weekend!
On episode 358 of the PC Update, Isaiah and Portia agreed to raise the baby together, all Jordan agreed on was that Curtis should have access to his baby. Let's see Lulu explore time and space with Maxie walking and talking in time and space. These future lovers could be reading a phone book and set the place on fire. This episode covers GH episodes from February 9th - 13th, 2026 *Music provided by Scott Holmes (song name - Electronic Vibes).
The Daily Drama Podcast with Steve Burton & Bradford Anderson
Steve talks about his upcoming hiatus from #GH. We discuss the demands of the job and what it's like to try to find balance in a career that seems to require anything but. Also, MAXIE woke up! What happens next?? To Watch This Episode Go To: https://youtu.be/o03ldKktYqw For Tour Dates Go To https://www.stonecoldandthejackal.com/tour Follow us on Facebook at: https://www.facebook.com/StoneColdandTheJackal/ Follow un on Instagram at https://www.instagram.com/stonecoldandthejackal/ Get even more on PATREON: https://www.patreon.com/stonecoldandthejackal
Nous sommes le 16 mars 1874. Le journal « L'Écho du Parlement » nous annonce que le « Musée fantaisiste » rouvre à la rue du Persil, à deux pas de la place des Martyrs, dans le centre de Bruxelles. Son fondateur, Louis Ghémar, a cassé sa pipe l'année précédente. « Casser sa pipe », en effet, car le farceur n'aurait sans doute pas apprécié la solennité d'un « décéder ». Quelques années plus tard, son ami Nadar, pionnier de la photographie, le décrira ainsi, dans ses Mémoires : « Sa bienveillante facilité, sa générosité, sa belle humeur irradiante, et quelque peu tapageuse en ces placides contrées, lui avaient de longtemps valu toutes les sympathies. Par sa fécondité particulière et comme quotidienne d'imaginations, d'improvisations burlesques et cocasses le plus souvent, pittoresques et décoratives toujours, dont il n'eut manqué de faire profiter les foules, il en vint à se créer une véritable popularité qui lui resta, jusqu'à la fin, fidèle. Dans ses gaîtés à froid, parfois énormes, ce Brabançon exemplairement sobre et qui semblait pourtant enluminé de tous les jus de la Bourgogne, joignait à l'entrain gouailleur du gamin de la Villette le pétillement, la fougue d'un fils de la Canebière. Il n'était pas en cette patrie de kermesses un bourgmestre un peu soucieux de sa cavalcade qui ne vint solliciter de Ghémar une consultation dont il retournait bien vite, triomphant, à ses administrés. Aux aimables pays dont les fabricants de fééries règlent les Constitutions, le bon Ghémar était de droit nommé et acclamé : Directeur de la Joie Publique ». Dessinateur, peintre, photographe, voyageur, lithographe, éditeur, architecte, galeriste, homme de presse, entrepreneur, franc-maçon, chansonnier, marionnettiste, mécène : Louis Ghémar était tout cela et plus encore, il était un amuseur pas dupe, un roi de la Zwanze. _______________________________________________________________ Avec nous : Eliane Van den Ende, historienne. sujets traités : Louis Ghémar, burlesque, photographe, fantaisiste, franc-maçon, chansonnier, marionnettiste, mécène, Zwanze, Nadar Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
On episode 357 of the PC Update, it's not breaking and entering when Chase does it. That's love, Jason bumps Anna making Britt a prior... A chance for new beginnings without a woman in the walls. This episode covers GH episodes from February 2nd - 6th, 2026 *Music provided by Scott Holmes (song name - Electronic Vibes).
This week on Port Charles 411, we continue our Fan Spotlight with Kim Hudson in Part 2 of a conversation so good it couldn't fit in one episode. We dive into GH theories (including Kim's Faison-as-AI idea), laugh over the show's science-adjacent chaos, and reflect on how story pacing has sped up over the years. We discuss Kristina's stalled storyline and brainstorm ways to give her momentum, what makes a legacy character like Lois memorable, and how GH works best when everyone has a story. Kim also shares insights on Willow's resilience, Nina's fierce loyalty, and the heartbreak of lost characters like Franco. Fans, theories, and GH history collide in this relaxed, spoiler-aware chat. Listen wherever you get podcasts — and if you'd like to be featured in a future Fan Spotlight, we want to hear from you! This podcast is not endorsed by, directly affiliated with, maintained, authorized, or sponsored by ABC Television Network, Prospect Studios, or any official General Hospital organizations. All product and company names are trademarks of their respective owners. Any use of trade names or trademarks is for identification and reference only and does not imply any association with the trademark holder. The views and opinions expressed on this podcast are solely those of the hosts and guests, and do not necessarily reflect those of any trademark or brand mentioned. Hosted on Ausha. See ausha.co/privacy-policy for more information. Learn more about your ad choices. Visit megaphone.fm/adchoices
The Daily Drama Podcast with Steve Burton & Bradford Anderson
We get to know GH's WSB Boss "Ross Cullum", ANDY HAWKES! Learn about his road to GH and how challenging it can be to be thrown into a show like ours, even for an accomplished actor like Andy. You'll be thrilled to learn that even though "Cullum" is not known for his warmth, Andy is a a pure delight:) For Tickets to all of our upcoming shows go to: https://www.stonecoldandthejackal.com/tour To watch this episode on YouTube go to: https://youtu.be/I3FxSSNrtJI Follow us on Facebook at: https://www.facebook.com/StoneColdandTheJackal/ Follow un on Instagram at https://www.instagram.com/stonecoldandthejackal/ Get even more on PATREON: https://www.patreon.com/stonecoldandthejackal