Podcasts about tnf

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Best podcasts about tnf

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Latest podcast episodes about tnf

Samz Sportz
Ugly Eliminations - Why Wednesday

Samz Sportz

Play Episode Listen Later May 19, 2022 120:36


Thanks for checking out Why Wednesday Via SamzSportz Podcast Network!!!!!The title of today's show will be Ugly EliminationsTake a second to check out everything on the SamzSportz network https://linktr.ee/SamzSportzsegments you might see today…Top 50 Big Board with B Da Analyst Fuk Wrong Wit Em with Dennis #RavenzSportz with BJ Debate with Derek Wit Derek#JunesCourt with June #KilosKorner with KeithThrowback Games With DerekShoutout to da Partners ✊

The Pat McAfee Show 2.0
PMS 2.0 663 - Feel Good Friday with Kirk Herbstreit, Ian Rapoport, and AJ Hawk

The Pat McAfee Show 2.0

Play Episode Listen Later May 13, 2022 130:02


On today's show, Pat, AJ Hawk and the boys show are safe and back in the studio after yesterday's fire & power outage. In the first hour, Kirk Herbstreit joins to show to discuss the ELECTRIC slate of TNF games he will be calling on Amazon Prime(0:26.54-0:57.35), Pat's journey from high school soccer to the NFL, and more. In the second hour, AJ joins the boys to break dahn the NFL Schedules and all of the NFL social media team's Schedule Release videos, with the Chargers' legendary anime movie roasting their opponents taking the cake. Later, NFL Insider and friend of the progrum, Ian Rapaport joins the show from a golf trip to talk through the schedule releases (1:40.58-2:00.27), latest rumors like if Sean Payton could be headed to the Panthers, whether he will ever work again, and much more. Make sure you subscribe to youtube.com/thepatmcafeeshow to watch the show and listen on Sirius XM Channel 82, Mad Dog Radio, We appreciate the hell out of you all. Have a great weekend, cheers.

Outkick the Coverage with Clay Travis
05/13/2022 – Best of 2 Pros and a Cup of Joe

Outkick the Coverage with Clay Travis

Play Episode Listen Later May 13, 2022 46:58


It's a Football Friday the 13th on 2 Pros and a Cup of Joe, with Jonas Knox, Brady Quinn and LaVar Arrington talking Creepy Clowns, Candyman and Billdos Flying to kick-off the season. They address rumors that the Panthers are looking at Sean Payton to replace Matt Rhule after this season. When looking at the NFL Schedule, the NFL may be preparing for a late season suspension of Deshaun Watson. Jonas spots a lie when it comes to TNF broadcasts and Kurt Warner needs to weigh in on Tom Brady joining FOX. See omnystudio.com/listener for privacy information.

Outkick the Coverage with Clay Travis
Hour 3: LaVar, Brady & Jonas – NFL Schedule Release Takeaways & More NIL

Outkick the Coverage with Clay Travis

Play Episode Listen Later May 13, 2022 39:13


When looking at the NFL Schedule, the NFL may be preparing for a late season suspension of Deshaun Watson. Jonas spots a lie when it comes to TNF broadcasts and Kurt Warner needs to weigh in on Tom Brady joining FOX. Iowa AD Gary Barta is the latest to suggest a solution to NIL. Plus, Madonna NFT's, Little Darlings and Jim Irsay hoarding on the BQ News. See omnystudio.com/listener for privacy information.

NFL Scotland
NFL Scotland Podcast - Ep 191. Our Wee Piece On The Schedule Release

NFL Scotland

Play Episode Listen Later May 13, 2022 48:04


Cameron, Gordon, Ian & Paul get together following the release of the 2022 NFL Schedule as we look at week 1, TNF, MNF, SNF and Thanks Giving fixtures.  We start with a cracking tie and share our thoughts on which of the selected prime time games will and won't be relevant.  We discuss the value of Brady in the booth and have info on an exciting giveaway we're having this weekend. 

Neurology Minute
Genetics and Neuroinflammation, Considerations for the Clinician - Part 2

Neurology Minute

Play Episode Listen Later May 3, 2022 2:34


Dr. Shuvro Roy discusses TNF-alpha Antagonism.

A hombros de gigantes
A hombros de gigantes - TP53, EGFR, APOE, POKEMON O ASTERIX, ¿Quién y cómo se nombran los genes? - 24/04/22

A hombros de gigantes

Play Episode Listen Later Apr 24, 2022 54:34


Asistimos a una revolución en el campo de la genética. Los últimos avances han permitido identificar cerca de 20.000 genes que codifican proteínas. Cada uno con su nombre, la mayoría de las veces muy parecidos a contraseñas informáticas (TP53, TNF, EGFR, APOE o AKTI) aunque en ocasiones presentan nombres llamativos como POKEMON, DIABLO, SPOCK o ASTERIX. Hemos entrevistado a Amparo Tolosa, directora científica y de contenido editorial de Genotipia, para conocer cómo se nombran los genes y quien se encarga de autorizarlo. Anna May nos ha informado de una tecnología desarrollada por investigadores del CSIC en el Instituto de Ciencia de Materiales de Barcelona para asegurar la autenticidad de los productos farmacéuticos. Con testimonios de Mariano Campoy. Con Bernardo Herradón nos hemos introducido en el grupo 14 de la Tabla Periódica, en el que se encuentran los elementos carbono, silicio, germanio, estaño, plomo y flerovio. En su recorrido por la obra de Ramón y Cajal, su Escuela y su legado, Fernando de Castro nos ha hablado de los discípulos de Lorente de Nó (Antonio Gallego, Yves Laporte, Luis Manuel Hernando de Larramendi, Vicente Honrubia y Jorge Larriva-Sahd, entre otros). Javier Ablanque nos ha llevado en su máquina del tiempo al año 1917 para visitar la United States Radium Corporation, en Nueva Jersey (EE. UU), y conocer la triste historia de las “chicas del radio", que trabajaron con este elemento radiactivo en la fabricación de relojes e indicadores luminiscentes. Hemos informado de la presentación del documental "Evolución, 250 años del Museo Nacional de Ciencias Naturales", uno de los eventos más esperados de los que ha preparado la institución para celebrar su aniversario. Y Esther García nos ha informado de la aspiración de Barcelona para convertirse en la capital mundial del turismo científico, con la colaboración del Consejo Internacional de la Ciencia, el CERN y los principales centros de investigación e innovación de la ciudad. Con testimonios de Alexis Roig, director ejecutivo de SciTech DiploHub   Escuchar audio

Oncotarget
How ONC201 Kills Breast Cancer Cells

Oncotarget

Play Episode Listen Later Apr 22, 2022 12:53


Dr. Stanley Lipkowitz and Dr. Yoshimi Endo Greer from the Women's Malignancies Branch at the National Cancer Institute discuss a research paper they co-authored that was published by Oncotarget in 2018, entitled, "ONC201 kills breast cancer cells in vitro by targeting mitochondria." DOI - https://doi.org/10.18632/oncotarget.24862 Correspondence to - lipkowis@mail.nih.gov Abstract We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in cancer cells. ONC201 was originally identified as a small molecule that induces transcription of TNF-related apoptosis-inducing ligand (TRAIL) and subsequently kills cancer cells by activating TRAIL death receptors. In this study, we examined ONC201 toxicity on multiple human breast and endometrial cancer cell lines. ONC201 attenuated cell viability in all cancer cell lines tested. Unexpectedly, ONC201 toxicity was not dependent on either TRAIL receptors nor caspases. Time-lapse live cell imaging revealed that ONC201 induces cell membrane ballooning followed by rupture, distinct from the morphology of cells undergoing apoptosis. Further investigation found that ONC201 induces phosphorylation of AMP-dependent kinase and ATP loss. Cytotoxicity and ATP depletion were significantly enhanced in the absence of glucose, suggesting that ONC201 targets mitochondrial respiration. Further analysis indicated that ONC201 indirectly inhibits mitochondrial respiration. Confocal and electron microscopic analysis demonstrated that ONC201 triggers mitochondrial structural damage and functional impairment. Moreover, ONC201 decreased mitochondrial DNA (mtDNA). RNAseq analysis revealed that ONC201 suppresses expression of multiple mtDNA-encoded genes and nuclear-encoded mitochondrial genes involved in oxidative phosphorylation and other mitochondrial functions. Importantly, fumarate hydratase deficient cancer cells and multiple cancer cell lines with reduced amounts of mtDNA were resistant to ONC201. These results indicate that cells not dependent on mitochondrial respiration are ONC201-resistant. Our data demonstrate that ONC201 kills cancer cells by disrupting mitochondrial function and further suggests that cancer cells that are dependent on glycolysis will be resistant to ONC201. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.24862 Press release - https://www.oncotarget.com/index.php?journal=oncotarget&page=news&op=press&item=onc201-kills-breast-cancer-cells-in-vitro-by-targeting-mitochondria Keywords - ONC201, breast cancer, mitochondria About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

The Gary Null Show
The Gary Null Show - 04.21.22

The Gary Null Show

Play Episode Listen Later Apr 21, 2022 60:29


Clinical Tests Reveal that Black Cumin Seed (Nigella Sativa) May Treat Hypothyroidism Tabriz University, April 13, 2022 Consuming a few grams of powdered Nigella sativa (NS), more commonly known as black cumin seeds, may improve the autoimmune thyroid condition known as Hashimoto's thyroiditis, according to a study published in the journal BMC Complementary and Alternative Medicine. Hashimoto's thyroiditis is the most common form of thyroid gland inflammation. It is also the most common thyroid disorder in the U.S. In fact, the disease affects 14 million people in the country alone. Data also showed that the condition will affect about five percent of the U.S. population. Hashimoto's thyroiditis was 15 times more prevalent in women compared with men. Women aged between 30 to 60 years had the highest prevalence of the condition. The study also revealed that patients who took the black seed supplement exhibited marked reductions in serum concentrations of thyroid stimulating hormone and anti-thyroid peroxidase antibodies at eight weeks of intervention. In addition, patients in the intervention group showed a notable decline in serum vascular endothelial growth factor levels. Researchers also highlighted a significant increase in triiodothyronine concentration in patients who received powdered black seeds. However, the experts did not observe a similar effect in patients who took a placebo pill. (NEXT) Following a Mediterranean-style diet during pregnancy may reduce the risk of preeclampsia Johns Hopkins University, April 20, 2022 Following a Mediterranean-style diet during pregnancy was associated with a reduced risk of developing preeclampsia, and Black women appeared to have the greatest reduction of risk, according to new research published today in the Journal of the American Heart Association. Preeclampsia, a condition during pregnancy characterized by severe high blood pressure and liver or kidney damage, is a major cause of complications and death for the mother and her unborn child. Preeclampsia also increases a woman's risk of heart diseases, such as high blood pressure, heart attack, stroke or heart failure, by more than two times later in life. Women with preeclampsia have a higher risk of preterm delivery (giving birth before 37 weeks gestation) or low birth weight babies, and children born to mothers with preeclampsia are also at higher risk of developing high blood pressure and heart disease. Researchers created a Mediterranean-style diet score based on participants' responses to food frequency interviews and questionnaires, which were conducted within three days of giving birth. The analysis found: Women who had any form of diabetes before pregnancy and pre-pregnancy obesity were twice as likely to develop preeclampsia compared to women without those conditions. The risk of preeclampsia was more than 20% lower among the women who followed a Mediterranean-style diet during pregnancy. Black women who had the lowest Mediterranean-style diet scores had the highest risk (78%) for preeclampsia compared to all other non-Black women who more closely adhered to the Mediterranean-style diet. (NEXT) Individuals with type 2 diabetes should exercise after dinner University of Missouri, April 18, 2022 Exercise is a popular prescription for individuals suffering from the symptoms of Type 2 diabetes, but little research has explored whether these individuals receive more benefits from working out before or after dinner. Now, researchers at the University of Missouri have found that individuals with Type 2 diabetes can lower their risks of cardiovascular diseases more effectively by exercising after a meal. "This study shows that it is not just the intensity or duration of exercising that is important but also the timing of when it occurs," said Jill Kanaley, professor in the MU Department of Nutrition and Exercise Physiology. "Results from this study show that resistance exercise has its most powerful effect on reducing glucose and fat levels in one's blood when performed after dinner." Kanaley and her colleagues studied a group of obese individuals with Type 2 diabetes. On one occasion, participants performed resistance exercises before eating dinner. During another visit, participants exercised 45 minutes after eating dinner. Participants performed resistance exercises such as leg curls, seated calf raises and abdominal crunches. Compared to levels on a non-exercise day, Kanaley found that the participants who exercised before dinner were able to only reduce the sugar levels in their blood; however, participants who exercised after dinner were able to reduce both sugar and fat levels. Participants consumed a moderate carbohydrate dinner on the evenings of the study. (NEXT) Dietary supplementation with açaí pulps improves cognition attenuates inflammatory signaling in BV-2 microglial cells Tufts University, April 18, 2022 Objectives: The present study was carried out to determine if lyophilized açaí fruit pulp (genus, Euterpe), rich in polyphenols and other bioactive antioxidant and anti-inflammatory phytochemicals, is efficacious in reversing age-related cognitive deficits in aged rats. Methods: The diets of 19-month-old Fischer 344 rats were supplemented for 8 weeks with 2% Euterpe oleracea (EO), Euterpe precatoria (EP), or a control diet. Rats were tested in the Morris water maze and then blood serum from the rats was used to assess inflammatory responses of BV-2 microglial cells. Results: After 8 weeks of dietary supplementation with 2% EO or EP, rats demonstrated improved working memory in the Morris water maze, relative to controls; however, only the EO diet improved reference memory. BV-2 microglial cells treated with blood serum collected from EO-fed rats produced less nitric oxide (NO) than control-fed rats. Serum from both EO- and EP-fed rats reduced tumor necrosis factor-alpha (TNF-α). There is a relationship between performance in the water maze and the production of NO and TNF-α by serum-treated BV-2 cells, such that serum from rats with better performance was more protective against inflammatory signaling.   (SUPERFOOD) Peppers (capsicum): Native American folk medicine, which has so many features we can still learn from, gave a prominent place in its pharmacology to peppers of the capsicum family, which includes bell and chili peppers. Recent work suggests that the nutrient capsaicin, found in these peppers, is a natural analgesic and a neuro-inflammatory blocker that relieves aches and pains to joints and muscles. This is one reason why Native American medicine prescribed a topical application of pepper to painful areas of the body. Capsaicin is particularly deserving of mention in this book because recent, promising research in Canada has explored the uses of capsaicin in the treatment of Type I diabetes. Other work has noted it can benefit sufferers from prostate cancer and leukemia. Some scientists have noted that this much studied nutrient found in peppers helps with weight loss, stimulation of insulin-producing cells, and prevention of LDL cholesterol oxidation. Another benefit recently uncovered is that the nutrient protects from stomach ulcerations and induces apoptosis (cancer cell death) in lung cancer. Setting aside the value of capsaicin, peppers can also be prized because they are rich in the antioxidant vitamins A as well as in vitamins B1, B6, E, and K. They are also high in potassium, magnesium, and iron. Yellow peppers are rich in lutein and zeaxanthin, which protect from eye disease and blindness. Videos: 1. American Who Lived 8 Years in Ukraine Speaks Out on Russia War (Start @ 0:41) 4. Kim Iversen: Noam Chomsky BLASTED By Liberals For Anti-War Stance, EXPOSING The New Pro-War Left 5. How the U.S. Media Betrayed Afghanistan (16:47 long)    

Saúde
Falta de sono na infância poderia afetar resposta imunitária na idade adulta

Saúde

Play Episode Listen Later Apr 19, 2022 5:14


Qual é a relação entre a quantidade de sono na primeira infância e o sistema imunológico na idade adulta? A pesquisadora francesa Sabine Plancoulaine, do Centro de Pesquisa em Epidemiologia e Estatísticas de Paris, do Inserm (Instituto de Pesquisas Médicas da França), sugere que crianças que têm períodos de sono mais curtos estariam mais predispostas ao desenvolvimento de várias patologias inflamatórias. Taíssa Stivanin, da RFI No estudo, a cientista francesa mostrou que períodos curtos de sono na primeira infância estão associados ao aumento, no sangue, de certas moléculas envolvidas em processos inflamatórios e na resposta imunológica. Essas moléculas, conhecidas como citocinas, estão presentes, em nível superior, em várias doenças, como diabetes, arteriosclerose ou depressão. O estudo utilizou os dados de um grupo de 687 crianças, que efetuaram exames de sangue aos cinco anos para medir os níveis de várias citocinas. Os pacientes que participaram do estudo não tiveram problemas de saúde e são filhos de mulheres recrutadas entre 2003 e 2006, na 24ª semana de gravidez, no hospital universitário de Nancy e Poitiers, no leste da França. Os exames de sangue foram realizados entre 2008 e 2011. A pesquisa concluiu que as crianças que dormiam menos de 10 horas e meia por dia, entre 2 e 5 anos, ou começaram a dormir bem menos nessa mesma idade, tinham níveis mais elevados, ainda que dentro da norma, de dois tipos de citocinas envolvidas nos processos inflamatórios: a chamada interleucina-6 (IL-6), substância ligada às ocorrências de reações inflamatórias e o TNF alpha (fator de necrose tumoral).  Essa alteração já havia sido detectada em outros estudos experimentais de privação de sono em adultos.  O aumento do nível das citocinas, explica a cientista, poderia ser preditivo de um problema de saúde futuro. “Esta é a minha hipótese, se observarmos os resultados obtidos, mas é preciso verificar se essa situação se mantém ao longo dos anos”, disse Sabine Plancoulaine em entrevista à RFI Brasil. “Ainda não sabemos, por exemplo, se essa taxa já estava aumentada antes dos dois anos de idade e se pode ser associada ao sono alterado”, completa. Nova pesquisa A próxima etapa agora é analisar se o nível de citocinas já era diferente quando as crianças nasceram e se há relação entre essas taxas e a duração do sono na primeira infância. A cientista lembra que as citocinas também são influenciadas pelo chamado ritmo circadiano, o mecanismo biológico que coordena processos fisiológicos do dia e da noite. “Em um período de 24 horas, o sistema imunológico não funciona da mesma maneira”, explica. “Na pesquisa, para levar esse aspecto em consideração, consideramos também o horário em que foi medido o nível das citocinas”, diz. A pesquisa atual já aponta para uma possível predisposição das crianças que dormem pouco para problemas de saúde na idade adulta. “Podemos imaginar que, se entre dois e cinco anos, as crianças já tinham níveis mais altos de citocinas, se isso continuar na idade adulta, o efeito será cumulativo”, diz a pesquisadora. “Podemos imaginar que, se continuarem a dormir pouco, os níveis de citocina poderiam aumentar cada vez mais e na idade adulta eles vão desenvolver problemas inflamatórios e patologias associadas à inflamação. “

Oncotarget
Secretomes from Metastatic Breast Cancer Cells and MSC Actions

Oncotarget

Play Episode Listen Later Apr 14, 2022 8:38


Jonathan Kelber and Francesca Sanchez from the Department of Biology, California State University Northridge, Northridge CA, discuss a research paper they co-authored for Oncotarget in 2019, entitled, "Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung." DOI - https://doi.org/10.18632/oncotarget.26903 Correspondence to - jonathan.kelber@csun.edu Abstract Cancer metastasis is responsible for the clear majority of cancer-related deaths. Survival and expansion of cancer cells at secondary sites requires that these premetastatic microenvironments be primed by primary tumor cells and their secreted factors. Efforts to date have been limited by immune-deficient in vivo models and/or the need for finely-tuned analysis time points that reduce contributions from early-disseminating cancer cells. In this regard, we developed a tumor cell-free syngeneic breast cancer model for characterizing tumor cell secretome-mediated reprogramming of premetastatic tissues. We demonstrate that secretomes from metastatic breast cancer cells differentially regulate the lung and brain, promoting a tumor-supportive lung microenvironment with both elevated CD73 expression and decreased TNFα expression. Using in vitro models of CD73-positive mesenchymal stem cells (MSCs) and macrophages/monocytes, we tested whether MSCs can mediate anti-inflammatory effects of metastatic breast cancer cells. Notably, conditioned media from metastatic Py230 cells reprogrammed the secretomes of MSCs toward an anti-inflammatory state. Mining transcriptome data from Py8119 and Py230 cells revealed a lipocalin 2 (LCN2) axis that is selectively expressed in the metastatic Py230 cells, predicts poor breast cancer patient survival and is elevated in circulating serum of mice chronically treated with conditioned media from Py230 cells. Taken together, these results establish the utility of an immune-competent tumor cell-free model for characterizing the mechanisms of breast cancer cell priming of the premetastatic niche, demonstrate that MSCs can mediate the anti-inflammatory effects of metastatic breast cancer cells and substantiate LCN2 as a promising therapeutic target for blocking breast cancer progression. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.26903 Press release - https://www.oncotarget.com/index.php?journal=oncotarget&page=news&op=press&item=secretomes-from-metastatic-breast-cancer-cells-enriched-for-a-prognostically-unfavorable-lcn2-axis-induce-anti-inflammatory-msc-actions-and-a-tumor-supportive-premetastatic-lung WATCH breast cancer playlist on Youtube - https://www.youtube.com/watch?v=za5mOwlmcFM&list=PL1auE_IUnQH5ja5Ukr9S8FWFcbOqR6NHj Keywords - premetastatic niche, tumor microenvironment, metastasis, breast cancer secretomes, LCN2 About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Empowered Patient Podcast
Extending the Healthy Human Lifespan by Addressing the Cause of Inflammation with Dr. Adam Kaplin MyMD Pharmaceuticals TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Apr 5, 2022


Dr. Adam Kaplin is the Chief Scientific Officer of MyMD Pharmaceuticals which is developing a drug that gets to the cause of inflammation. Since chronic inflammation is a factor in pathological aging, managing inflammation shows opportunities for slowing aging. Their lead drug MyMD-1 is a TNF-a inhibitor that can cross the blood-brain barrier and treat the brain where other anti-TNF-a treatments do not.    Adam explains, "By delaying aging, what I mean is they not only lived longer, but they didn't lose their function. So, they retained their strength and their cognition. Because if we were only developing a drug that would just allow us all to get older and demented, that wouldn't be good for the economy, good for our personal health, good for anybody. So really, what we're excited about is the prospect of actually slowing the aging process and extending the healthy portion of our lifespans." "So, aging probably is going to end up being the result of two primary processes. One is inflammation, and that is the product of having an immune system which is all set up to fight off infection. And not just fight off infection -- it turns out, inflammation is also a part of how we develop." "The second most important thing I think is that these drugs, the anti-TNF-a treatments like HUMIRA, do not have any benefit for the brain. I mean, they can cause things that look like MS, but they certainly have no benefit for CNS inflammatory conditions. And among those are MS, lupus, but also dementias. Alzheimer's now has been implicated to have inflammation involved. So, crossing over the blood-brain barrier's a big deal. It's orally available. Additionally, all the other TNF-a inhibitors have to be taken by a needle in some way, injection or infusion." @MyMDPharma #Health #Medical #Aging #Lifespan #Sarcopenia #Immunology #Immunesystem #Inflammation #Cytokines #CytokineStorm #TNFa #BloodBrainBarrier MyMD.com Listen to the podcast here

Empowered Patient Podcast
Extending the Healthy Human Lifespan by Addressing the Cause of Inflammation with Dr. Adam Kaplin MyMD Pharmaceuticals

Empowered Patient Podcast

Play Episode Listen Later Apr 5, 2022 16:42


Dr. Adam Kaplin is the Chief Scientific Officer of MyMD Pharmaceuticals which is developing a drug that gets to the cause of inflammation. Since chronic inflammation is a factor in pathological aging, managing inflammation shows opportunities for slowing aging. Their lead drug MyMD-1 is a TNF-a inhibitor that can cross the blood-brain barrier and treat the brain where other anti-TNF-a treatments do not.    Adam explains, "By delaying aging, what I mean is they not only lived longer, but they didn't lose their function. So, they retained their strength and their cognition. Because if we were only developing a drug that would just allow us all to get older and demented, that wouldn't be good for the economy, good for our personal health, good for anybody. So really, what we're excited about is the prospect of actually slowing the aging process and extending the healthy portion of our lifespans." "So, aging probably is going to end up being the result of two primary processes. One is inflammation, and that is the product of having an immune system which is all set up to fight off infection. And not just fight off infection -- it turns out, inflammation is also a part of how we develop." "The second most important thing I think is that these drugs, the anti-TNF-a treatments like HUMIRA, do not have any benefit for the brain. I mean, they can cause things that look like MS, but they certainly have no benefit for CNS inflammatory conditions. And among those are MS, lupus, but also dementias. Alzheimer's now has been implicated to have inflammation involved. So, crossing over the blood-brain barrier's a big deal. It's orally available. Additionally, all the other TNF-a inhibitors have to be taken by a needle in some way, injection or infusion." @MyMDPharma #Health #Medical #Aging #Lifespan #Sarcopenia #Immunology #Immunesystem #Inflammation #Cytokines #CytokineStorm #TNFa #BloodBrainBarrier MyMD.com Download the transcript here

The Gary Null Show
The Gary Null Show - 04.05.22

The Gary Null Show

Play Episode Listen Later Apr 5, 2022 61:54


Vegan diet eases arthritis pain, finds new study   Physicians Committee for Responsible Medicine, April 4, 2022   A low-fat vegan diet, without calorie restrictions, improves joint pain in patients with rheumatoid arthritis, according to a new study conducted by researchers at the Physicians Committee for Responsible Medicine. Study participants also experienced weight loss and improved cholesterol levels. “A plant-based diet could be the prescription to alleviate joint pain for millions of people suffering from rheumatoid arthritis,” says Neal Barnard, MD, lead author of the study and president of the Physicians Committee. “And all of the side effects, including weight loss and lower cholesterol, are only beneficial.”   (NEXT)   Researchers Discover Cannabis-Mushroom Combination That “Kills Over 90% Of Colon Cancer Cells”   Cannabotech Integrative (Israel), April 1, 2022   For the last several years, scientists with Cannabotech, a biomedical company developing oncological products using cannabis, have been developing an “Integrative-Colon” product they say kills over 90% of colon cancer cells. According to Cannabotech, they have concluded a study using not only cannabis, but a unique combination of cannabinoids and mushroom extracts, which they tested on various colon cancer subtypes, representing different molecular changes common in these colon cancer subtypes. Their results of the cell model study were astounding, showing that its “Integrative-Colon” products killed over 90% of colon cancer cells — and they attribute this to to the mushroom and cannabis combination. Given the fact that the survival rate for colorectal cancer is just 65%, the idea that an easily grown plant and fungus could be used to save hundreds of thousands of lives, is inspiring to say the least. Humans share more DNA with mushrooms than we do with plants, a lot more.   (NEXT)   Vitamin C could help reduce toxic side effects of common cancer treatment    University Nove de Julho (Brazil), April 4, 2022   A study conducted in rats suggests that taking vitamin C may help to counteract the muscle atrophy that is a common side effect of the chemotherapy drug doxorubicin. Although clinical studies would be needed to determine the safety and effectiveness of taking vitamin C during doxorubicin treatment, the findings suggest vitamin C may represent a promising opportunity to reduce some of the drug's most debilitating side effects. “Our results suggest vitamin C as a potential adjunct therapy to assist in the management of peripheral muscle disorders after treatment with doxorubicin, thereby improving functional capacity and quality of life and reducing mortality,” said Antonio Viana do Nascimento Filho, a master's student in medicine at University Nove de Julho (UNINOVE) in Brazil, first author of the study. Nascimento Filho will present the findings at the American Physiological Societyannual meeting during the Experimental Biology (EB) 2022 meeting, held in Philadelphia April 2–5.   (NEXT)   Stress markers high, antioxidants low in breast cancer patients   University of Lahore (Pakistan), April 4 2022.    Research revealed blood inflammatory and stress marker variations between women with breast cancer and those who did not have the disease. The study compared 498 women with breast cancer with an equal number of age-matched women without the disease. Serum samples were analyzed for matrix metalloproteinases, interleukins, heat shock proteins, tumor necrosis factor-alpha (TNF-a, a proinflammatory cytokine), nitric oxide, inducible nitric oxide synthase, malondialdehyde (MDA, a marker of oxidative stress), vitamins A, C and D, the antioxidant glutathione, and antioxidant enzymes superoxide dismutase (SOD) and catalase. Compared to women who did not have breast cancer, breast cancer patients exhibited overexpression of the inflammatory marker matrix metalloproteinase 9, the proinflammatory protein interleukin-1, heat shock protein 27 (which can be protective as well as destructive), TNF-a, nitric oxide, inducible nitric oxide synthase and MDA. Women with breast cancer had low levels of vitamins A, C and D, glutathione, catalase and SOD.  

装备说
EP22: 春暖花开买包包!越野登山户外活动选包指南来啦

装备说

Play Episode Listen Later Apr 5, 2022 93:22


春暖花开,喜欢户外运动的朋友们肯定按捺不住激动的心情,想要去户外登山、越野跑等等,今天我们就带来一期越野跑背包相关的内容。选包主要依据:跑动/运动距离,携带物品,补给条件,天气因素,强装要求,个人能力等方面综合考量。大致上非特殊天气的情况下,30K内短距离及日常户外徒步、登山、越野跑训练4L容量即可,30-70k距离赛事5-8L容量,50-100k建议8-12L容量,100k以上15升容量。当下胸前软壶是主流储水方式,绝大部分品牌越野包均配500mlx2软壶,补水方便,饮料和清水可随意安排,行动或跑动重心更合理。部分5L以上容量的背包也支持使用背部水袋,优点是储水量大,但补水不方便,也不便于观察余量。然后是分品牌介绍:UltimateDirection:目前迭代至5.0系列,后侧舒适收束系统是其最大特点。同时UD品牌分男女款,注意尺码参考是肋骨下缘围度。TO系列8.5升,SJ系列10.3升,AK系列13.4升,PB系列17升(单壶),HALO系列男11升女9升(4.0系列,专为utmb打造的轻量竞速款式)该品牌旗下还有儿童款越野背包,徒步背包,跑步腰包等满足不同距离不同场景的补水和背负需求。BlackDiamond:4升/8升/15升 颜值高,Z杖收纳方便。SALOMON:SLAB系列ultra5升/8升 精英款,轻薄,面料弹性大,特别能塞,需要外挂杖袋实现手杖收纳。ADV系列 5升/8升(女款)/12升 ,大众款,收纳空间更多,面料更耐用。PRO系列 5升/10升(分别有女款)新推出系列,更像是slab和adv两大系列的结合体。ACTIVE系列 8升 新推出款,入门款,设计简单实用。COMPRESSPORT:8升,拉链背心式,面料弹性大,通过蹦床测试,可容纳百英里级别强制装备。TNF:国内目前仅有1款8升容量在售卖,日本产品线款式更丰富。迪卡侬:3升 收纳空间有限/5升 需搭配杖袋才能收纳手杖/10升/15升凯乐石:飞翼air8 更新到第二代,特点是boa旋钮,可单手调节,多种手杖收纳方式。/飞翼flow13 背部分仓多,收纳空间大。/solid系列8升12 升 基础款。优极:6升/10升,背部下侧有旋钮调节(有儿童款背包)。引擎鸟:8升,类似凯乐石的旋钮调节。奥尼捷:借鉴起家,产品丰富,性价比高,评价两极分化,远销海外。NATHAN:老牌补水品牌,最近比较低迷。ARC'TERYX:前几年出过7/14两款,后续无更新,市面存量也不多。开头提到的几大因素可以确定需要选择的容量,具体到品牌和款式,可对应产品图片考虑每个口袋适合收纳的物品,结合自己的使用习惯确定。尺码选择时要考虑穿衣情况,适当流出厚衣服的余量。另外节目中还就7月份即将重启的崇礼168越野赛的各组别比赛进行了简要的装备分析,也欢迎大家收听。=======================微博 / 小程序 / 服务号:@跑者日历公众号: 跑者日历RUN365 各音频及播客平台:跑者日历=======================应大家的要求,我们终于有了自己的听众群,欢迎各位跑友进群交流。可以通过添加客服微信号:run365cs ,拉你入群。期待你的加入,一起听,一起跑

The Gary Null Show
The Gary Null Show - 04.01.22

The Gary Null Show

Play Episode Listen Later Apr 2, 2022 60:29


Resveratrol supplementation associated with improved glucose regulation in diabetics   National University of Medical Sciences (Pakistan) March 30 2022.    The June 2022 issue of Complementary Therapies in Medicine reported findings from a randomized trial that uncovered positive effects for supplementing with resveratrol in the regulation of glucose and the maintenance of healthy levels of inflammation and oxidative stress in type 2 diabetics. The trial included men and women who were being treated with orally administered drugs for type 2 diabetes.  Forty-five participants received 200 milligrams resveratrol per day and 46 received a daily placebo for 24 weeks. Blood samples collected at the beginning and end of the trial were analyzed for plasma glucose, insulin, hemoglobin A1c (a marker of long-term glucose control), lipids, malondialdehyde (a marker of oxidative stress), circulatory microRNAs associated with diabetes, and markers of inflammation that included tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP).   (NEXT)   Eating peanuts may lead to supple arteries and healthy hearts   Pennsylvania State University, March 29, 2022   Eating peanuts with a meal may help protect against cardiovascular diseases which can lead to heart attacks and stroke, according to an international team of researchers. In the study, overweight and obese but otherwise healthy men who ate about three ounces of peanuts with a high-fat meal had a blunted increase of lipids in their bloodstream. According to the researchers eating peanuts can keep the cells that line the arteries healthy, helping them stay more elastic. The researchers showed that when peanuts are eaten with a meal the typical post-meal increase of triglycerides -- a type of fat found in the bloodstream -- is blunted. According to the researchers, there was a 32 percent reduction in the triglyceride levels after the consumption of the peanut meal compared to the control group. Three ounces of peanuts is about three times the amount of an average serving size, according to the researchers.   (NEXT)   NIH Study confirms: Turkey Tail mushrooms boost immunity in women with breast cancer   University of Minnesota and Bastyr University, March 28, 2022   Turkey Tail mushrooms can boost your immune system so significantly that it may even shrink breast cancer tumors. A $2 million, seven-year clinical study funded by the National Institutes of Health and jointly conducted by the University of Minnesota and Bastyr University showed that Trametes versicolor, or turkey tail mushroom, in freeze-dried form, dramatically boosts immune function for women with Stage I-III breast cancer─ possibly shrinking tumors. One theory is that when patients ingest Turkey Tail mycelium, the immune system's increased populations of NK cells and their associated CD8 glycoproteins are better able to discover and bind to receptor sites on the stroma of tumors, thus allowing NK invasion. If true, then the use of this medicinal mushroom as an adjunct or preventative therapy may help many patients better fight the battle when challenged with tumor-forming cancers.”   (NEXT)   Too Much Screen Time is Really Bad for Teen Well-Being   University of Queensland School of Health, March 31, 2022    Whether it's watching TV or playing games, teens experience serious physical and mental health consequences after just two hours of screen time, according to new research The global study of more than 400,000 adolescents is the first to provide evidence that both passive and mentally active screen time adversely affects teens' mental well-being. Teens are more likely to report psychosomatic symptoms, a combination of physical and psychological complaints, if they exceed two hours of screen time and these effects were similar regardless of physical activity levels. Psychological complaints from teens included feeling low, irritable, nervousness, and sleeping difficulty, and somatic complaints included headaches, abdominal pain, backache, and dizziness.   Guest: Jessica Rose Part 2 

BioTech IQ
#44 Addressing One Of The World's Biggest Drivers Of Disease: Inflammation With Jim Woody, M.D., Ph.D. - CEO 180 Life Sciences

BioTech IQ

Play Episode Listen Later Apr 1, 2022 46:18


TNF is a protein that contributes to inflammation. Anti-TNFs can be used to stabilize this and stop the inflammation. It's used for diseases like arthritis and psoriasis. Discover how clinical trials are done so these medicines and anti-TNFs can be utilized. Join Ammon Rivera as he talks to M.D., Ph.D. and CEO of 180 Life Sciences, Jim Woody about anti-TNFs and the trial process behind them. Jim's goal is to address one of the biggest drivers of disease – inflammation. Learn more about Jim's career as a venture capitalist. Find out why trials need to be uniform and randomized. And, discover what it takes to run a biotech company today.

Oncotarget
Down Syndrome iPSC Model: Endothelial Perspective on Tumor Development

Oncotarget

Play Episode Listen Later Mar 31, 2022 6:07


Mariana Perepitchka, Yekaterina Galat, and Dr. Vasiliy Galat discuss their 2020 research paper published by Oncotarget, entitled, "Down syndrome iPSC model: endothelial perspective on tumor development." DOI - https://doi.org/10.18632/oncotarget.27712 Correspondence to - Mariana Perepitchka - mperepitchka@u.northwestern.edu, Yekaterina Galat - ygalat@luriechildrens.org, and Vasiliy Galat - v-galat@northwestern.edu Abstract Trisomy 21 (T21), known as Down syndrome (DS), is a widely studied chromosomal abnormality. Previous studies have shown that DS individuals have a unique cancer profile. While exhibiting low solid tumor prevalence, DS patients are at risk for hematologic cancers, such as acute megakaryocytic leukemia and acute lymphoblastic leukemia. We speculated that endothelial cells are active players in this clinical background. To this end, we hypothesized that impaired DS endothelial development and functionality, impacted by genome-wide T21 alterations, potentially results in a suboptimal endothelial microenvironment with the capability to prevent solid tumor growth. To test this hypothesis, we assessed molecular and phenotypic differences of endothelial cells differentiated from Down syndrome and euploid iPS cells. Microarray, RNA-Seq, and bioinformatic analyses revealed that most significantly expressed genes belong to angiogenic, cytoskeletal rearrangement, extracellular matrix remodeling, and inflammatory pathways. Interestingly, the majority of these genes are not located on Chromosome 21. To substantiate these findings, we carried out functional assays. The obtained phenotypic results correlated with the molecular data and showed that Down syndrome endothelial cells exhibit decreased proliferation, reduced migration, and a weak TNF-α inflammatory response. Based on this data, we provide a set of genes potentially associated with Down syndrome's elevated leukemic incidence and its unfavorable solid tumor microenvironment—highlighting the potential use of these genes as therapeutic targets in translational cancer research. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27712 Press release - https://www.oncotarget.com/news/pr/down-syndrome-ipsc-model-an-endothelial-perspective-on-tumor-development/ Keywords - Down syndrome, iPSC-derived endothelial model, T21 genome-wide Implications, meta-analysis, tumor microenvironment About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Evidence Based Hair
Evidence Based Hair - Season 1, Episode 8

Evidence Based Hair

Play Episode Listen Later Mar 29, 2022 50:08


Recording of the Evidence Based Hair Podcast for the March 28, 2022 issue.       STUDIES HIGHLIGHTED   Trueb RM et al (starts at 3:27). Minoxidil-induced hypertrichosis in a breastfed infant. J Eur Acad Dermatol Venereol. 2022 Mar;36(3):e224-e225.   Gangal et al (starts at 7:08). Mask-associated acquired trichorrhexis nodosa of the beard. JAAD Case Rep. 2022 Mar;21:101-102.   Trueb RM et al. Prepubertal pattern hair loss (starts at  13:38) Clin Exp Dermatol. 2022 Jan;47(1):173-175.):24-30   Katayama S et al (starts at 17:00). Rapidly Progressive Hair Loss May Be the Only Sign of Syphilis. Am J Med 2022 Feb 22;S0002-9343(22)00130-9.   Kolla et al (starts at 32:34). Dermatologists' knowledge of dermoscopic features in hair and nail disorders. J Eur Acad Dermatol Venereol. 2022 Feb 11.   Rutnin S et al (starts at 37:32)). Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study. Skin Appendage Disord. 2022 Jan;8(1):24-30.   Xie et al (starts at 42:27). Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis. Cell Stem Cell 2022 Jan 6;29):

The Chase Thomas Podcast
The Full Ride: 5 Big College Football Questions With Matt Green. Plus, NHL Trade Deadline Recap With ESPN's Greg Wyshynski

The Chase Thomas Podcast

Play Episode Listen Later Mar 24, 2022 85:36


Outsider and Blue Wire's Chase Thomas is joined by fellow University of North Georgia alumni Matt Green to talk about Florida AD Scott Strictlin's way of describing his hiring process, the Vols landing Nico, Georgia trending positively for Arch Manning, Herbstreit to TNF on Amazon, Arkansas's upside with Sam Pittman, Iowa not evolving on offense, spring hype for the Gamecocks, which next big-name Power 5 head coach will leave his school next and much more (3:00). Then, ESPN's Greg Wyshynski joins the program to talk about the NHL Trade Deadline, winners and losers, the Florida Panthers going for it, the New Jersey Devils standing pat, Claude Giroux returning to the Flyers, John Gibson not getting moved, and much more (60:00). Host: Chase Thomas Guests: Matt Green, Greg Wyshynski Learn more about your ad choices. Visit podcastchoices.com/adchoices

WARR on Anchor
2nd City Sports on SportZone Chicago: Much Madness; More Trades; RIP John Clayton

WARR on Anchor

Play Episode Listen Later Mar 22, 2022 112:34


One weekend down, two to go in March Madness. On this latest edition of 2CS, Sid and Lakeena recap the early rounds of the NCAA tournament, look ahead at Patrick Williams' return to the Bulls and salute LeBron now becoming No. 2 on the NBA's all-time scoring list. Plus, the NFL is still wild with trades, including one coming across while we're on the air. Also, the effect of Correa signing with the Twins, the networks making new set-ups for top NFL announcers and we remember ESPN NFL columnist and TV personality John Clayton. 2:19 - March Madness recap: Illinois loses to Houston; Arizona avoids an upset while five double digit seeds make the Sweet 16, including this year's definitive Cinderella - St. Peter's 39:13 - Bulls and NBA talk: P-Will's back, but is it time for the Bulls to panic?; LeBron passes Karl Malone for No. 2 on all-time scoring list; the Nuggets are struggling; this week's games 1:12:43 - NFL news: Watson is traded to the Browns; Matt Ryan traded to the Falcons 1:23:34 - MLB news: Correa goes to the Twins; Story signs with the Red Sox; Astros manager Dusty Baker shares a sweet moment with son, Darren 1:28:45 - Sports media: Al Michaels heading to Amazon to do TNF; Kevin Burkhardt and Greg Olsen front runners to be FOX's No. 1 NFL team; Details of Joe Buck's trade from FOX to ESPN are revealed; Former FOX Chicago and NBC Sports Chicago personality Siera Santos joins the MLB Network; We remember John Clayton 1:35:12 - Blackhawks make statement trading Marc-Andre Fleury to the Wild; Flyers send veteran Claude Giroux to the Panthers 1:37:24 - Sports hodgepodge: previewing Thursday's Sweet 16 matchups in the West and South regions; Jameis Winston returns to the Saints; US men's tennis player Taylor Fritz beats Rafa Nadal to win in Indian Wells You can catch 2CS each Monday and Friday live from 12 pm to 2 pm on SportsZone Chicago's platforms. Download the SportsZone Chicago app for more information on their programs and where to watch them. Subscribe to WARR on Anchor and follow WARR Media for all the latest on our movement and stay tuned for upcoming episodes and specials from your comrades at WARR. Weareregalradio.com provides the best independent coverage of sports and culture -- feel free to share our content and rate us well here or wherever else you find our podcasts. Thanks for listening. --- Send in a voice message: https://anchor.fm/warrmedia/message Support this podcast: https://anchor.fm/warrmedia/support

Black in Sports Podcast
Karyn "KB" Bryant | UFC Anchor | "You have to play the game" | S3 EP 1

Black in Sports Podcast

Play Episode Listen Later Mar 10, 2022 60:04


We kicked off season 3 interviews with UFC Anchor Karyn Bryant. In episode one KB really opens up and shares an all to common narrative of black women/women of color in sports & entertainment. We learned about Karyn's up bringing which gives her foundation in sports growing up in the Boston area. A small decision from becoming a lawyer to a life of entertaining us through the fight for more, is the story of ups and downs, please know KB is not done!We talk about her shows "What Had Happened Was" w/ Angela Hill live Sunday nights. KB's other show "Festivities" and "TNF after party" w/Renato Laranja is on Tuesday nights! She is showing a new side of her self and playing the game. So Tap in......More with Karyn Bryant: http://www.KarynBryant.com http://www.fistivities.com http://instagram.com/kbheat http://twitter.com/KarynBryant --For more Black in Sports additional content on our podcast see linktree: https://linktr.ee/blackinsports |Facebook - https://www.facebook.com/blackinsports | YouTube - @blackinsports | Instagram - @blackinsports | Twitter - @blackinsports | Website - https://www.blackinsports.com/ | Thank you & we appreciate you! #awardwinningpodcast #bestsportspodcast #blackpodwinner#fortheculture #blackinsports #sportsbusiness #podcast #tellingblackstories #blackowner #Blackeffect #sportsbiz #BlackPlayersForChange #sportsnews #blackowned #blackmedia #HBCULeaguePass #blackpodcastmatter #UFC #KarynBryant #womenshistory #blackwomen

Podcast Notes Playlist: Latest Episodes
Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

Podcast Notes Playlist: Latest Episodes

Play Episode Listen Later Mar 9, 2022 69:36


Lifespan with Dr. David Sinclair ✓ Claim Podcast Notes Key Takeaways Our medical model of “wait until you get sick then go to the doctor” really won't get you where you want to go – the insurance system in the U.S. won't cover testing unless you're sickYou can't impact what you don't measure! Be proactive about measuring and keeping track of what's happening in your body through bloodwork and helpful wearablesTechnology isn't waiting for the laws: it's a matter of when not if – we need data security and privacy protection laws in place, including the right to delete your data, before the use of wearables is rampantWearables and sensors will eventually collect thousands of data points per second and ultimately contribute to “lengthening our lives another decade beyond what we're able to do with changes to lifestyle” – according to Dr. David SinclairThe key is really to take action based on the information you're getting from the wearables and sensors  Supplementation is particularly important for people on a specialized diet – you need to be vigilant about measuring bloodwork to make sure you're doing what's best for your bodyDavid Sinclair's 5 biomarkers worth measuring: (1) glucose; (2) heart function (3) inflammation as measured by, c-reactive protein (CRP), tumor necrosis factor (TNF) alpha, cortisol; (4) lactate; (5) blood oxygen“This is the kind of life I want for everybody, that we don't have to worry about getting cancer in our 50s and 60s and having a heart attack in our 70s. We should be able to live to our 70s, 80s, 90s and beyond in a healthy way, contributing to society, contributing to the community, educating our kids…” – Dr. David SinclairTake responsibility for yourself, and do it for your kids and grandkids' sake: eat the right way, fast, get exercise, give your body a little stress, supplement as needed, monitor your health proactivelyRead the full notes @ podcastnotes.orgIn the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook Matthew LaPlante's Social: Twitter To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Timestamps: (00:00:00) Introducing Episode Eight: The Future of Anti-aging Medicine (00:03:49) Thanking the Sponsors (00:06:48) Modern Healthcare, Disease Detection, and Circulating DNA (00:11:30) Wearable Monitors: A Dashboard for your Body (00:20:31) Types of Health Sensors (00:24:20) Big Data, Privacy, and Criminal Investigation (00:30:16) Cutting-edge Testing and Biological Age (00:36:40) Using Personalized Data to Inform your Diet (00:41:48) Optimizing Exercise and Activity-mimetics (00:45:02) Resetting the Aging Clock (00:53:45) Repeatable Age Reversal and Safety (00:56:11) Longer Life, Population Size, and Economics (01:00:18) Skillbatical (01:03:06) Putting in the Work for Longevity (01:04:56) Thanking the Podcast Team and Wrapping Up Season One (01:08:27) Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Title Card Photo Credit: Mike Blabac Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

3 and Out with John Middlekauff
Ridley Gambling Scandal, Rodgers Decision, Russ/Carr Pursuit, NFL Free Agency, Cap Casualties, Top Headlines, Mailbag

3 and Out with John Middlekauff

Play Episode Listen Later Mar 8, 2022 69:06


John discusses the gambling scandal involving Calvin Ridley betting on games and why the NFL needs to make an example of him to send a message, why Aaron Rodgers decision to stay or leave Green Bay is similar to LeBron's "Decision", why Russell Wilson and Derek Carr are probably not going anywhere despite furious pursuit by a number of teams, why free agency is always going to involve over paying players, and how front offices around the league target desirable cap casualties like Amari Cooper. He also runs through some of the top headlines from around he league, including the Chiefs likely parting ways with Honey Badger, Bill Belichick contemplating naming himself as the Pats next OC, how Aaron Donald and Matt Stafford extensions will impact the Rams cap situation, and reports that Kirk Herbstreit will jump ship from ESPN to Amazon for TNF. Finally, he answers listener questions in the Middlekauff Mailbag. Follow John and The Volume on Twitter, Instagram and YouTube for the latest content and updates and check out FanDuel for the best wagering and daily fantasy action! Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

The Herd with Colin Cowherd
3 and Out - Ridley Gambling Scandal, Rodgers Decision, Russ/Carr Pursuit, NFL Free Agency, Cap Casualties, Top Headlines, Mailbag

The Herd with Colin Cowherd

Play Episode Listen Later Mar 8, 2022 69:06


John discusses the gambling scandal involving Calvin Ridley betting on games and why the NFL needs to make an example of him to send a message, why Aaron Rodgers decision to stay or leave Green Bay is similar to LeBron's "Decision", why Russell Wilson and Derek Carr are probably not going anywhere despite furious pursuit by a number of teams, why free agency is always going to involve over paying players, and how front offices around the league target desirable cap casualties like Amari Cooper. He also runs through some of the top headlines from around he league, including the Chiefs likely parting ways with Honey Badger, Bill Belichick contemplating naming himself as the Pats next OC, how Aaron Donald and Matt Stafford extensions will impact the Rams cap situation, and reports that Kirk Herbstreit will jump ship from ESPN to Amazon for TNF. Finally, he answers listener questions in the Middlekauff Mailbag. Follow John and The Volume on Twitter, Instagram and YouTube for the latest content and updates and check out FanDuel for the best wagering and daily fantasy action! Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

Into Sports and Stuff
Ep. 89 - The Piss Bucket

Into Sports and Stuff

Play Episode Listen Later Mar 4, 2022 72:10


On this week's episode we review the Leafs/Red Wings Barn burner, and the Jets/Habs match up. We talked about politics and how Russia/Ukraine is affecting the landscape of sports. MLB has cancelled the first 2 series of the season after failing to reach an agreement with the MLBPA. Hosk's got stuff to talk about including Shaq and his pee bucket, upset city in NCAAB, Amazon firing big money at potential TNF analysts, Tiger wins the PIP, Verstaapen gets paid and we recap Celebrity Big Brother. We introduce the return of our Big Brother Canada game and we make our picks for the season. Jones puts us on The Grill where we discuss; Makar or Shesterkin for Hart nomination and we play a start/sit/bench game. Get yourself a pair of MeUndies and receive 20% off your first order by following the link - http://getcomfy.in/v/intosportsandstuff Visit TeePublic for all your Into Sports and Stuff Merchandise Needs - http://tee.pub/lic/intosportsandstuff Follow us on Twitter: @IntoSportsStuff Follow us on Instagram: @IntoSportsandStuff

Engearment with Sean Sewell
Post North Face Meeting, Patagonia, Hestra, Mountain Hardwear, Spark R&D

Engearment with Sean Sewell

Play Episode Listen Later Feb 28, 2022 8:50


Post North Face Meeting, Patagonia, Hestra, Mountain Hardwear, Spark R&D Thanks for making the Engearment Podcast the #1 Fitness podcast in Nepal! We had a great meeting with The North Face two weeks ago. They put us up in a nice room in Winter Park and fed us great food.  We hung out with TNF athletes and other media companies as we tested out the newest gear for 2022-2023 on the mountain. We have reviews up on that gear on our YouTube channel - check then out here - https://www.youtube.com/channel/UCxAprJXsIhdEPtai7jP0JNg?view_as=subscriber We also worked on projects for Patagonia, Mountain Hardwear and Kuhl.   There is a fun tour of Hestra HQ and a preview of what is new for next season. Spark R&D sent over next year's Surge to test as well. Thanks for all the support!  

High Hopes Sportscast
S1 E6 I called it! It's about time!!

High Hopes Sportscast

Play Episode Listen Later Dec 18, 2021 79:23


DJ and JJ talk about the crazy past couple days with all the Covid cases in the league. Urban Meyer is finally out of Jacksonville!! They recap TNF and go through this weeks matchups as they call out Matt Rhule on his QB situation. And JJ proposes we take High Hopes Sportscast to the Super Bowl in Vegas in 2024! Lol --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/hhsportscast-4/message Support this podcast: https://anchor.fm/hhsportscast-4/support

3 y Fuera NFL
Jaguars despide a Urban Meyer, el COVID-19 amenaza a la NFL y previa Chiefs-Chargers en TNF | Ep. 675

3 y Fuera NFL

Play Episode Listen Later Dec 16, 2021 18:29


Analizamos la patética gestión del HC Urban Meyer al frente de Jaguars, los más de 100 casos de COVID-19 en la NFL y el duelo en TNF de semana 15 entre Chiefs y Chargers con Jaime Inchaurrandieta. We analyze Urban Meyer's pathetic era with the Jaguars, the over 100 COVID-19 cases in the NFL and preview Week 15's TNF between Chiefs and Chargers with Jaime Inchaurrandieta (audio in Spanish). ¡La NFL no termina y nosotros tampoco! Sigue a Cuarta y Gol en Youtube, Instagram, Tiktok, Twitter, Facebook y mail Suscríbete al podcast aquí Conductores: Rudy Jacinto (@paradojaNFL) y Jaime Inchaurrandieta (@inchaurrandieta)

High Hopes Sportscast
S1 E5 Why is this guy still coaching a team?!

High Hopes Sportscast

Play Episode Listen Later Dec 15, 2021 63:39


The guys talk about all the honor Demaryius Thomas has gotten since his passing. DJ talks about his frustration with the Urban Meyer situation and they recap week 14 and talk about the upcoming TNF game. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/hhsportscast-4/message Support this podcast: https://anchor.fm/hhsportscast-4/support

High Hopes Sportscast
S1 E4 OH MY GOD, Kirk Cousins actually won a primetime game!!!

High Hopes Sportscast

Play Episode Listen Later Dec 11, 2021 62:06


The guys talk coaching changes that could happen in the off season. A former MIN kicker gets PAID! They recap the crazy TNF and cover week 14 games and give their picks. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/hhsportscast-4/message Support this podcast: https://anchor.fm/hhsportscast-4/support

3 y Fuera NFL
Vikings vence 36-28 a Steelers, DEP Demaryius Thomas y NFL picks de semana 14 con Jaime Inchaurrandieta | Ep. 672

3 y Fuera NFL

Play Episode Listen Later Dec 10, 2021 51:41


Vikings ganó sufriendo contra Steelers en TNF de semana 14. A medio partido, descubrimos del lamentable fallecimiento del WR Demaryius Thomas. Finalmente analizamos, hacemos picks y recomendaciones apuestas para el resto de la semana 14. Vikings struggled to win vs Steelers in Week 14's Thursday Night Football. Halfway through the game, it was revealed WR Demaryius Thomas lost his life due to unkown causes. Finally, we analyze, pick winners and recommend bets for all Week 14 games (audio in Spanish). ¡La NFL no termina y nosotros tampoco! Sigue todas las plataformas de Cuarta y Gol aquí. Conductores: Rudy Jacinto (@paradojaNFL) y Jaime Inchaurrandieta (@inchaurrandieta)

Mic'd Up
Should Players Play Bowl Games

Mic'd Up

Play Episode Listen Later Dec 10, 2021 68:50


Mello and BIg Country preview the historic Army vs Navy matchup this weekend and dive into the TNF game between the Steelers and Vikings. The boys also go over who they think has a good chance at a Super Bowl this year and who is just plain bad.

3 y Fuera NFL
Previa Steelers vs Vikings en TNF de semana 14: Kirk Cousins vs T.J. Watt por el sueño de postemporada | Ep. 671

3 y Fuera NFL

Play Episode Listen Later Dec 9, 2021 11:37


Analizamos el Steelers vs Vikings en Thursday Night Football de semana 14, incluyendo las bajas del WR Adam Thielen y la posible baja del RB Dalvin Cook en Minnesota. También discutimos las lesiones más importantes a mitad de semana. We analyze the TNF matchup between Steelers and Vikings in week 14, including Adam Thilene being out and Dalvin Cook potentially missing this game in Minnesota. We also discuss the most important injuries to monitor (audio in Spanish). ¡La NFL no termina y nosotros tampoco! Sigue todas las plataformas de Cuarta y Gol aquí. Conductor: Rudy Jacinto (@paradojaNFL) y Carlos Rosado (@carlosrosadov)

Yahoo Sportsbook Daily
Steelers at Vikings betting primer

Yahoo Sportsbook Daily

Play Episode Listen Later Dec 9, 2021 5:02


Frank Schwab is your TNF betting guru this week with a lean on the game line and a few player props ahead of this massive matchup with playoff implications on the line between the Minnesota Vikings and the Pittsburgh Steelers. New BetMGM customers who bet $1 on ANY game will receive $100 in free bets added to their account. You don't need to win your bet to receive the promotion. Must be 21+ in AZ, CO, IN, IA, MI, NJ, PA, TN, VA, WV, WY only. Terms apply. Go to BetMGM.com/YAHOOSPECIAL to get started or use promo code SPORTSBOOK when making your first deposit. See acast.com/privacy for privacy and opt-out information.

High Hopes Sportscast
S1 E3 HELLO!! You're playing to WIN. THE. GAME!!!!

High Hopes Sportscast

Play Episode Listen Later Dec 8, 2021 76:13


The guys recap week 13 games, notable injuries and talk about 2 unique records set by a couple players in the past week. Briefly cover TNF matchup and JJ gets a little heated! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/hhsportscast-4/message Support this podcast: https://anchor.fm/hhsportscast-4/support

High Hopes Sportscast
S1 E2 Ultimate upset!

High Hopes Sportscast

Play Episode Listen Later Dec 4, 2021 45:15


Recap of TNF, and the guys give their take on who they think should win the MVP as of now. They make their picks as they go over the week 13 matchups and DJ makes a CRAZY upset pick! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/hhsportscast-4/message Support this podcast: https://anchor.fm/hhsportscast-4/support

Desde las Líneas podcast | Vanguardia Mx
T2 | E18 Las apuestas de la semana 13. NFL en Diciembre

Desde las Líneas podcast | Vanguardia Mx

Play Episode Listen Later Dec 2, 2021 65:46


Lucky week 13. ¿Es la semana para confiarle nuestro pick a los Steelers? ¿Rebotaran los Cowboys en su segundo TNF consecutivo? ¿Detroit ML? Alberto y César platican sobre todos los partidos de esta semana de la NFL desde el punto de vista de líneas de apuestas. --- Send in a voice message: https://anchor.fm/vanguardia-mx-deportes/message

The Sack City Podcast
Ep153: TNF Recap/Week 11 predictions

The Sack City Podcast

Play Episode Listen Later Nov 20, 2021 67:09


So how good ARE the Patriots? Are they really Superbowl Contenders! Aaron and AJ break down the TNF Stinker and then predict the Sunday Slate ahead. #RCODBrought To You By The Belly Up Sports NetworkSponsored by Yeetz Sunglasses:https://yeetzofficial.com/Use Promo Code: RCOD for 10% OffRoughcut Merchandise:https://www.bonfire.com/store/shop-rough-cut/Follow Us On Social Media:Facebook: https://www.facebook.com/RoughCutSportsTwitter: https://twitter.com/RoughCut_SportsInstagram: https://www.instagram.com/theroughcutsportscast/Youtube: https://www.youtube.com/channel/UCPO5II-X27FVACCc6qo30gQTiktok: https://www.tiktok.com/@theroughcutDon't Forget To Hit That Download ButtonLeave A Review, So We Can Be Better For You

Shock Fantasy
SuperBowl LI Rematch - Falcs at Pats

Shock Fantasy

Play Episode Listen Later Nov 18, 2021 10:51


What else do you want to know about this podcast? We're previewing the TNF game! Duh.

Shock Fantasy
Black Birds and Not-Quite Porpoises Battle on Thursday Night Football

Shock Fantasy

Play Episode Listen Later Nov 10, 2021 14:15


The Ravens and Dolphins square off on TNF. Who should you start, sit and throw in your DFS lineups? Only Mat knows! Literally, he's the only one.

The Sack City Podcast
Ep146: Top 5 Disappointing NFL Teams

The Sack City Podcast

Play Episode Listen Later Nov 5, 2021 59:56


As we approach the Midway Point, We rank the top teams that haven't quite played up to par!#RCODBrought To You By The Belly Up Sports NetworkSponsored by Yeetz Sunglasses:https://yeetzofficial.com/Use Promo Code: RCOD for 10% OffRoughcut Merchandise:https://www.bonfire.com/store/shop-rough-cut/Follow Us On Social Media:Facebook: https://www.facebook.com/RoughCutSportsTwitter: https://twitter.com/RoughCut_SportsInstagram: https://www.instagram.com/theroughcutsportscast/Youtube: https://www.youtube.com/channel/UCPO5II-X27FVACCc6qo30gQTiktok: https://www.tiktok.com/@theroughcutDon't Forget To Hit That Download ButtonLeave A Review, So We Can Be Better For You

Yahoo Sportsbook Daily
TNF Betting preview: Colts take on the Jets

Yahoo Sportsbook Daily

Play Episode Listen Later Nov 4, 2021 4:21


Minty Bets gets you set for the TNF matchup featuring the Indianapolis Colts and the New York Jets. Will the Colts cover the -10.5 points? Minty also selects a couple of props she likes as well.New BetMGM customers who bet $1 on ANY game will receive $100 in free bets added to their account. You don't need to win your bet to receive the promotion. Must be 21+ in AZ, CO, IN, IA, MI, NJ, PA, TN, VA, WV, WY only. Terms apply. Go to BetMGM.com/YAHOOSPECIAL to get started or use promo code SPORTSBOOK when making your first deposit. See acast.com/privacy for privacy and opt-out information.

The Sack City Podcast
Ep 143: TRC Top 5 Bubble Teams

The Sack City Podcast

Play Episode Listen Later Oct 29, 2021 61:27


It's TNF with two of the Top teams in the NFL. We break down which team has the edge. Plus We tell you what teams outside the playoff race, has the best chance of turning their season around!#RCODBrought To You By The Belly Up Sports NetworkSponsored by Yeti:Roughcut Merchandise:https://www.bonfire.com/store/shop-rough-cut/Follow Us On Social Media:Facebook: https://www.facebook.com/RoughCutSportsTwitter: https://twitter.com/RoughCut_SportsInstagram: https://www.instagram.com/theroughcutsportscast/Youtube: https://www.youtube.com/channel/UCPO5II-X27FVACCc6qo30gQTiktok: https://www.tiktok.com/@theroughcutDon't Forget To Hit That Download ButtonLeave A Review, So We Can Be Better For You

NFL: Good Morning Football
NFL Owners meetings, Cardinals fan Blake Shelton, Super Bowl Champ Aquib Talib, Scary teams in Week 8, and Fantasy Football picks

NFL: Good Morning Football

Play Episode Listen Later Oct 27, 2021 39:48


In the latest edition of the Good Morning Football Podcast, hosts Kay Adams, Kyle Brandt, Peter Schrager, and Shaun O'Hara get updates from the NFL Owners meetings in New York. We hear NFL Commissioner Roger Goodell addressing the WFT emails and discuss Deshaun Watson questions. Country star and Cardinals fan Blake Shelton drops by to preview Arizona's TNF matchup against the Packers. Super Bowl Champion Aquib Talib tells us why he's picking the Rams in the NFC. Plus, we get Fantasy Football picks and the scariest teams heading into NFL Week 8. The Good Morning Football Podcast is part of the NFL Podcast Network. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com See omnystudio.com/listener for privacy information.

Shock Fantasy
Broncos v Browns... Not John Elway and Bernie Kosar

Shock Fantasy

Play Episode Listen Later Oct 21, 2021 11:52


It won't be THE DRIVE, but it will be breathtaking. Here's the best plays for the TNF game between the Broncos and Browns. This just in, it's kind of gross, but there's a few flecks of gold here.

Shel-Shocked
Episode 23: Previewing TNF

Shel-Shocked

Play Episode Listen Later Oct 21, 2021 49:04


In the 23rd episode of Shel-Shocked, Shelby and BK Preview Thursday Night Football. Before they get into the game, Shelby offers his thoughts on what it'll take to get his team back on track following 3 straight losses (2:33). He looks back at the Raiders game and what went wrong (9:31) and Shelby breaks down the Browns, including their backup running backs and what it will be like to go against Case Keenum (17:46). Shelby also weighs in on the Bucks Championship Rings and who the best Pumpkin Carver in his family is.

NFL: Good Morning Football
Patriots release Stephon Gilmore, Browns-Chargers important matchup, Super Bowl Champion Cliff Avril on Rams-Seahawks TNF

NFL: Good Morning Football

Play Episode Listen Later Oct 6, 2021 42:49


In the latest edition of the Good Morning Football Podcast, hosts Kay Adams, Kyle Brandt, Peter Schrager, and Michael Robinson discuss the importance of Browns-Chargers this week. Fantasy Football questions answered along with which team has the most exciting offense in the NFL. Breaking news with Stephon Gilmore being released by the Patriots. Plus, Super Bowl Champion Cliff Avril talks Russell Wilson and prepares us for Rams-Seahawks on TNF. The Good Morning Football Podcast is part of the NFL Podcast Network. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com See omnystudio.com/listener for privacy information.

Double Coverage With The McCourty Twins
Episode #75 | We Not Really Rivals | S3E3

Double Coverage With The McCourty Twins

Play Episode Listen Later Oct 6, 2021 41:40


We back! They tried to break up the band, but blood is thicker than water. Even with J in Miami, the pod must go on. The fellas recap the previous week of football, preview the next week matchups, cover what's poppin' in the group chat, and more.  Pull up as Dev and J debate whether there are actual rivals in the NFL; do they players really care when they are playing a team in their division or is that just for the fans? A couple days after TB12's big return to New England, the twins also debate about the best QBs they've ever played against...and they don't agree. Is Urban Meyer tripping for being caught turning up at a bar in Ohio a couple days after Jags go 0-4 in a TNF loss?  Giving you the insider at the ups and downs of the NFL season from the player's eyes week-to-week. Pull up on us! Subscribe to the Double Coverage Podcast on Apple Music, Spotify, or wherever you listen to your podcasts! Produced by:  https://malkasports.com Media Inquiries:  kevin@malkasports.com Learn more about your ad choices. Visit megaphone.fm/adchoices

NFL: Good Morning Football
Brady-Belichick Showdown, Mike Tirico talks Brees/Gruden, Nate Burleson, and Pigskin Picks!

NFL: Good Morning Football

Play Episode Listen Later Oct 1, 2021 39:14


In the latest edition of the Good Morning Football Podcast, hosts Kay Adams, Kyle Brandt, Peter Schrager, and Matt Cassel explain why the Bengals win on TNF could be pivotal for Joe Burrow and the franchise. We preview some marquee matchups in NFL Week 4 before NBC's Mike Tirico tells us about being on the field for Brady v Belichick in Foxborough. Nate Burleson drops by and we give Kay's top five fantasy players and Pigskin Picks. The Good Morning Football Podcast is part of the NFL Podcast Network. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com See omnystudio.com/listener for privacy information.