Podcasts about Thursday Night Football

Erin Coscarelli and Rob Havenstein are joined by Andrew Whitworth to break down the Rams' seismic offseason, headlined by the blockbuster trade for Myles Garrett to pair with a potentially returning Aaron Donald. Whitworth explains how L.A.'s revamped secondary — built around new corners Trent McDuffie and Jaylen Watson — solves the coverage issues that plagued the defense last year, and details how Sean McVay's staff will likely move Garrett around alongside Braden Fiske, Kobie Turner, and Byron Young up front. The two also dig into the Rams' looming contract crunch on the offensive line, with Whitworth predicting the team leans toward locking up interior players first to protect Matthew Stafford.   0:01 - 3:45): Introductions and personal nicknames. (4:14 - 6:45): Discussion on the Myles Garrett trade and potential Rams roster moves. (7:16 - 10:20): Impact of the revamped secondary and defensive depth. (10:21 - 14:00): Tactical fit for Myles Garrett in the Rams' defense and impact on NFC West opponents. (14:05 - 16:32): Strategies for pairing Aaron Donald and Myles Garrett on the defensive front. (16:41 - 22:01): Analysis of the Rams' offensive line contract situations. (22:04 - 23:07): A brief, humorous touch on Taylor Swift's wedding. (23:09 - 28:10): Recapping the American Century Championship golf tournament in Tahoe. (28:31 - 33:14): Thoughts on LSU football, coaching changes, and the 2018 "No Call" memory. (33:15 - 34:49): Wrap up and anticipation for the upcoming Thursday Night Football season. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Erin Coscarelli and Rob Havenstein are joined by Andrew Whitworth to break down the Rams' seismic offseason, headlined by the blockbuster trade for Myles Garrett to pair with a potentially returning Aaron Donald. Whitworth explains how L.A.'s revamped secondary — built around new corners Trent McDuffie and Jaylen Watson — solves the coverage issues that plagued the defense last year, and details how Sean McVay's staff will likely move Garrett around alongside Braden Fiske, Kobie Turner, and Byron Young up front. The two also dig into the Rams' looming contract crunch on the offensive line, with Whitworth predicting the team leans toward locking up interior players first to protect Matthew Stafford.   0:01 - 3:45): Introductions and personal nicknames. (4:14 - 6:45): Discussion on the Myles Garrett trade and potential Rams roster moves. (7:16 - 10:20): Impact of the revamped secondary and defensive depth. (10:21 - 14:00): Tactical fit for Myles Garrett in the Rams' defense and impact on NFC West opponents. (14:05 - 16:32): Strategies for pairing Aaron Donald and Myles Garrett on the defensive front. (16:41 - 22:01): Analysis of the Rams' offensive line contract situations. (22:04 - 23:07): A brief, humorous touch on Taylor Swift's wedding. (23:09 - 28:10): Recapping the American Century Championship golf tournament in Tahoe. (28:31 - 33:14): Thoughts on LSU football, coaching changes, and the 2018 "No Call" memory. (33:15 - 34:49): Wrap up and anticipation for the upcoming Thursday Night Football season. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Broadcast from KSQD, Santa Cruz on 7-09-2026: Researchers refined a technique to reverse skin cell aging by about 30 years while preserving cellular identity. Exposing adult fibroblasts to Yamanaka factors—stopping before full reversion to pluripotent stem cells,reset the epigenetic clock and gene expression patterns to resemble much younger cells. The rejuvenated fibroblasts produced significantly more collagen, migrated faster to close artificial wounds, and showed reversal of gene expression patterns associated with Alzheimer's and cataracts. Since long-term epidemiologic data doesn't yet exist, Dr. Dawn follows up on last week's vaping question by exploring cancer mechanisms. Vaping aerosols impair DNA repair fidelity while triggering IL-6, IL-8, and TNF-alpha secretion. Nicotine-derived nitrosamines, reactive carbonyls (formaldehyde, acetaldehyde, acrolein) are generated when propylene glycol and vegetable glycerin are heated. Upregulated cytochrome P450 enzymes convert precarcinogens like benzopyrene into carcinogens. Mice exposed for 54 weeks developed lung adenocarcinomas in 22% and precancerous bladder hyperplasia in 57%, with markers matching those show predict lung cancer years before diagnosis. The Mexican Biobank—which includes over 40,000 samples from all 31 Mexican states revealed dramatic regional variation in drug-metabolism genes driven by Indigenous ancestry. In Chiapas, nearly 40% of the population carries two copies of a CYP2D6 variant reducing fentanyl metabolism, versus just 10% in Sinaloa. The SLCO1B1 variant hindering statin metabolism is found in over 15% of Yucatán residents., where 8 million Mexicans take statins. Dr. Dawn discusses both the promise and potential dark side of population genetic testing, including UK plans to genotype all children at birth for inborn errors of metabolism. Dr. Dawn briefly revisits the recent Indian study showing conch-shell blowing reduces sleep apnea by 34%, comparing it to earlier didgeridoo research, both of which strengthen airway muscles through forced-blowing exercises. A caller from Capitola recovering from non-Hodgkin's lymphoma near the L5 nerve asks about Japanese Kampo medicine formulas (Goshajinkigan, Yokukansan) for post-treatment nerve pain. Dr. Dawn suggests the pain likely originates from scar tissue tethering the nerve, and recommends consulting the Oriental Medicine Doctor program at Five Branches in Santa Cruz where faculty can advise on herbal formulas that trace back thousands of years through cultural exchange between China and Japan. Dr. Dawn explains Lp(a):lipoprotein(a), a small protein string attached to LDL particles that promotes clumping and clotting, is a genetically-determined coronary artery disease and stroke risk factor invisible to standard lipid panels. Levels of 250 particles double coronary risk and 350 particles triple it. Less than 75 is normal. Two new pharmaceutical strategies are in development to reduce Lp(a) : antisense oligonucleotides (single-stranded RNA that recruits RNase H to cleave target mRNA) and small interfering RNA (double-stranded RNA that triggers destruction of matching mRNA). Pelacarsen, a monthly injection in Phase 3 trials, reduces Lp(a) by 80%. These gene-silencing platforms open therapeutic possibilities for previously undruggable orphan diseases. Vitamin K2 is produced in the gut microbiome. MK-4 is most common in humans. Dr. Dawn recommends MK7 for stabilizing coronary calcium plaques and directing calcium into bone. A study of hepatitis B and C patients found MK4 to be protective in hepatocellular carcinoma. HCC developed in 2 of 21 MK-4-treated patients versus 9 of 19 controls, with a risk ratio of 0.2. MK-4 activates protein kinase A in vitro, inhibits HCC invasiveness, and restores apoptosis signaling that cancer cells normally block. Dr. Dawn recommends a couple milligrams of MK-4 daily for anyone with cirrhosis or prior hepatitis B or C infection.

The Dockers pull-off one of the craziest wins in recent memory, 6PR was all over all the action on Thursday Night Football, here's the highlights. See omnystudio.com/listener for privacy information.

Broadcast from KSQD, Santa Cruz on 7-02-2026: Dr. Dawn devotes the first half of the show to a nuanced defense of GLP-1 receptor agonists, arguing the polarized debate treats obesity as a moral failure rather than a physiological one. She recounts the "Marilyn Monroe dress" moment that transformed semaglutide from diabetes drug into elite cosmetic tool, and pushes back on the puritanical framing that behavior change must be earned rather than pharmacologically enabled—noting we don't apply this logic to antihypertensives or statins. Dr. Dawn catalogs visceral fat as a genuine endocrine organ producing over 17 hormones, most of which drive self-perpetuating growth: leptin (this satiety hormone at high levels disables it's own brain receptor), IL-6, TNF-alpha (blocks insulin), resistin (increases insulin resistance and inflammation), PAI-2 (blocks clot breakdown, raising cardiovascular risk), retinol-binding protein 4 (impairs muscle glucose uptake), chemerin (recruits macrophages and directs fat to the belly), and visfatin. Only adiponectin declines with rising visceral fat. It improves insulin sensitivity, suppresses hepatic gluconeogenesis, and blocks IL-6 . Dr. Dawn describes GLP-1's neurobiological action: receptors in the hypothalamus, brainstem, hippocampus, and mesolimbic reward system, with the drugs quieting the brain's salience network so food loses its intrusive pull. Taste buds shift, sweet and salty become muted, and reward circuits stop firing on cheat foods—creating a window during which behavioral change becomes possible. Dr. Dawn frames group support through self-determination theory (autonomy, competence, relatedness), arguing GLP-1s create the cognitive bandwidth for behavioral programs to succeed. A Tufts study of patients discontinuing after 10% weight loss found those enrolled in behavioral support programs regained about three times less weight than usual-care controls, outperforming even medically-tailored meal plans. Group engagement doubled the time patients stayed on the medication. A November 2025 Nature study piggybacked on deep brain stimulation research at Penn. Electrodes implanted in the nucleus accumbens of post-bariatric patients recorded low-frequency brain activity surges during food-noise episodes on drug free patients. A third participant who started tirzepatide showed complete silencing of that signature—the first direct electrical confirmation that GLP-1s suppresses compulsive food thoughts in the reward center. RNA sequencing of adipose tissue from 25 obese patients before and after bariatric surgery, compared to 24 lean controls, revealed persistent epigenetic changes even after weight loss. Lipid-associated inflammatory macrophages drop but retain some of their pro-inflammatory epigenetics, explaining the well-known slippery slope back to obesity—and why Dr. Dawn suggests GLP-1s may work best as intermittent tools when behavioral maintenance starts slipping. An emailer asks about long-term smoking versus vaping data. Dr. Dawn notes there is no long-term data yet, but short-term evidence shows e-cigarettes contain nicotine, propylene glycol, reactive oxygen species, and nitrosamines, producing spirometry readings similar to mild COPD in otherwise-healthy vapers. Vaping over a year raises stroke relative risk by 1.62 and nearly doubles MI risk, and combining smoking and vaping produces a multiplicative rather than additive harm. Data on cancer will take decades to emerge. Researchers built a functioning underwater breathing apparatus for cockroaches with electrodes attached to brain and sensory organs allowing remote-controlled direction while preserving natural obstacle-navigation autonomy. The 10mm × 10mm sponge-based oxygen tank uses magnesium dioxide catalyzing hydrogen peroxide breakdown, delivering oxygen through silicone tubes to the roach's spiracles for up to three hours underwater. Deployemenet will improve search-and-rescue in flooded and collapsed structures where dogs cannot reach. A Science Advances paper from Yong Lin Kong's lab at Rice University describes 3D-printing electronic circuits directly onto living tissue. Researchers achieved microwave-focused annealing at sub-200-micrometer resolution. By selectively heating only conductive ink particles (copper, silver, gold) without damaging surrounding tissue, the technique enables printing circuits onto 3D-printed heart valves, tracheas, and ear scaffolds, potentially creating combined graft-and-sensor implants, ingestible diagnostic devices, and perhaps even decorative electronic tattoos. A single-shot reformulation of zanamivir (originally the inhaled flu drug Relenza) provided 76.1% flu protection in a 5,000-participant trial—far exceeding the roughly 40-45% offered by annual flu vaccines. Because zanamivir targets neuraminidase in a way that inactivates it if the virus tries to mutate around the drug, trapping newly-made viral copies inside their host cells, this approach works across all flu strains and could bypass the annual guessing game of trivalent vaccine formulation.

HEALTH NEWS   Melatonin may safely reduce chronic musculoskeletal pain, study finds Study: Nordic Walking Reduces Depression Symptoms Within Weeks Connection or compulsion: How smartphones can deepen depression in older adults This Popular Workout Supplement May Give Cancer Immunotherapy a Big Boost Probiotic metabolite found to suppress melanoma tumor growth in mice   Melatonin may safely reduce chronic musculoskeletal pain, study finds University of Sydney, June 30 2026 (News-Medical) A sleep supplement widely used to treat insomnia could help reduce reliance on some of the most common and potentially harmful pain medications, new research from the University of Sydney suggests.  Published in PAIN, the study found melatonin can reduce chronic musculoskeletal pain with effects in a similar range to medications such as opioids, non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol.  The study analyzed data from 2028 adults across 23 randomised controlled trials conducted in countries including the United States, Russia, Brazil, Egypt and China. Participants included people with conditions such as low back pain, osteoarthritis and fibromyalgia, as well as those recovering from surgeries including joint replacements and spinal procedures.  On average, the study found that melatonin reduced pain by around nine points on a 0-100 scale, with the most rigorous trials showing reductions closer to 10 points, a similar magnitude to widely used pain medications. Across the trials, the dose and timing of melatonin varied depending on the condition and setting. For chronic musculoskeletal pain, doses typically ranged from 3 to 10 mg, with 3 mg per day the most commonly used. For postoperative pain, doses ranged from 1 to 10 mg, with 5 to 6 mg most common. Melatonin was generally taken at bedtime or up to one hour before sleep.     Study: Nordic Walking Reduces Depression Symptoms Within Weeks Université Grenoble Alpes (France), July 1 2026 (Natural News)   A randomized controlled trial published in the Journal of Affective Disorders found that supervised Nordic walking significantly reduced depression symptoms in adults with moderate to severe depression. The most pronounced improvements occurred within the first five weeks of the 10-week program, according to researchers. The study enrolled 64 adults, with 48 assigned to Nordic walking and 16 to a non-active control group.   The findings challenge the commonly cited three-month timeframe for exercise benefits on depression. A secondary analysis examined whether participants with severe depression responded differently than those with moderate symptoms. According to the study, Nordic walking is a low-impact activity that engages the upper and lower body using poles, similar to cross-country skiing. The Nordic walking group showed significantly greater reductions in depression symptoms compared to the control group over the full 10 weeks. The largest reduction occurred from baseline to week five, with a large effect size; improvements from week five to week ten were smaller and not statistically significant. Participants with severe depression at baseline experienced even larger and faster improvements in the first five weeks, according to the secondary analysis.   Connection or compulsion: How smartphones can deepen depression in older adults Rutgers University, July 1 2026 (Eurekalert)   Compulsive smartphone habits in older adults can be linked to a higher risk of depression, according to a study led by a Rutgers researcher.  Researchers said their findings raised concerns that technology widely promoted to build connections can instead deepen late-life isolation: While mobile devices can be invaluable lifelines, their impact on mental health depends heavily on the way people use them. A critical distinction, the researchers said, is whether someone uses technology to actively engage with the world or to withdraw. The study, published in JMIR Aging, drew on survey responses from 2,585 adults ages 60 and older living in 87 communities. Researchers collected health and demographic information, including age, gender, marital status, education and income, and measured depressive symptoms with a screening tool commonly used with older adults. Limited social participation emerged as the strongest predictor of depression, followed closely by smartphone addiction, defined as compulsive or excessive use that disrupts daily functioning. Problematic phone reliance appeared in nearly all cases of clinical depression, with older adults who rarely used interactive communication features facing the greatest risk. Another high-risk pattern emerged among older adults of both sexes: Those with higher incomes and education levels who suffered from smartphone addiction were more prone to clinical depression. This finding suggests that wealth, education, and technology access fail to protect against loneliness when screen time replaces real-world connections.   This Popular Workout Supplement May Give Cancer Immunotherapy a Big Boost University of California at Los Angeles, July 1, 2026 (SciTech Daily) Creatine, a supplement widely used by athletes and bodybuilders, may also strengthen the immune system's ability to fight cancer, according to new research from UCLA. Previous findings from the same research team show that creatine boosts the activity of killer T cells, which destroy cancer cells. The new research found that creatine also supports dendritic cells, the immune cells responsible for detecting tumor material and activating killer T cells to launch an attack. Although many approved cancer immunotherapies target killer T cells, only about 20% to 40% of patients benefit from these treatments. Enhancing dendritic cells, which prepare and activate T cells, could improve the effectiveness of immunotherapy for more people. The researchers found that dendritic cells inside tumors produced much higher levels of the gene responsible for the creatine transporter, the protein that moves creatine into cells, than dendritic cells found in healthy tissue. They investigated whether increasing creatine could improve dendritic cell performance. Daily creatine injections in mouse models of melanoma slowed tumor growth while increasing both the number and activity of dendritic cells within tumors. The treated dendritic cells also released more chemical signals that attracted additional immune cells to the tumor.     Probiotic metabolite found to suppress melanoma tumor growth in mice Southern Medical University (China), June 30 2026 (News-Medical)   Immune checkpoint inhibitors like anti-PD-1 have transformed melanoma treatment, yet more than half of patients fail to respond or eventually develop resistance. The tumor microenvironment and the gut microbiome are increasingly recognized as critical determinants of immunotherapy outcomes. Melanoma patients often show reduced levels of beneficial gut bacteria, including Bifidobacterium, and lower microbial diversity. Researchers have discovered that Bifidobacterium animalis—a probiotic commonly found in fermented dairy products—produces mannose, which activates CD8⁺ T cells and suppresses melanoma progression in mouse models. The study reveals a novel gut-microbiome-immune axis that could lead to new adjuvant strategies for melanoma immunotherapy.   When given orally to mice with melanoma tumors, the bacterium significantly reduced tumor volume and weight—without ever colonizing the tumor tissue itself, indicating that its effects were mediated entirely through secreted metabolites. Using size fractionation and metabolomics, the team identified mannose as the key bioactive molecule—a small, non-protein compound under 3 kilodaltons. In mice, drinking water supplemented with 1% mannose replicated the anti-tumor effects of the live probiotic, increasing tumor-infiltrating CD8⁺ T cells and boosting their production of killer molecules like granzyme B (GZMB), interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α).

We try to decipher the "Thursday night Football" of various other aspects of life.

We get Lauren's thoughts on celebrating the 4th, ranking NFL TV times, Thursday Night Football, and the Kansas City Questionnaire.

Rich weighs in on how different the landscape of Los Angeles basketball will look after the departures of LeBron James from the Lakers and Kawhi Leonard from the Clippers. Thursday Night Football Analyst Ryan Fitzpatrick and Rich discuss the sky-high expectations for the Rams after Los Angeles' trade for 2-time Defensive Player of the Year Myles Garrett, if he's more bullish on the Buffalo Bills, Kansas City Chiefs or Cincinnati Bengals to win the AFC this season, breaks down the Atlanta Falcons' and Minnesota Vikings' QB competitions, and their upcoming appearance in the ACC Tahoe Celebrity Golf Tournament. Rich and the guys react to Rory McIlroy flexing his back-to-back Masters wins by wearing his green jacket to Wimbledon. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Derm on RheumNow podcast is a collection of Citations and Content curated for dermatologists – addressing Psoriasis, PsA, CLE, vasculitis, HS, other CTD skin disorders. dermatology drugs, biiologics, JAKs - their use, efficacy and side effects. Features Dr. Jack Cush, Editor at RheumNow.com. Show Notes: - Breckenridge Pharmaceutical received FDA approval for their generic version of tofacitinib on 6/4/26. 5 mg and 10 mg tablets are now available in the U.S. market, for both adult and pediatric use. Tofacitinib Tablets are manufactured in Martorelles, Spain. https://t.co/oAh0KQSFgs - TB Infection or reactivation is Psoriasis or Psoriatic Arthritis pts taking IL-23 inhibitors is rare, rare. Literature review showed 34 studies of IL-23i in PsO had no new TB, but 1 case of LTBI reactivation. In 8 IL-23i PsA studies there were NO new TB or LTBI reactivations https://t.co/NFIap7DSOr   - BE BOLD: Bimekizumab Beats Risankizumab (LB0001) –H2H trial bimekizumab vs risankizumab in PsA for 24 weeks. At week 16; BKZ better than RZB,  p=0.0058). This advantage was maintained out to week 24 (55% vs 44%; p 0.0001). - RA-BRIDGE and RA-BRANCH: FDA mandated study of the risk of venous thromboembolic events (VTE) taking baricitinib (BARI) or TNF inhibitors. The incidence rate was 0.79/100 PY for BARI combined versus 0.51/100 PY for TNFi. The hazard ratio was 1.606 (95% CI 0.969–2.660), with the upper CI exceeding the pre-specified NI margin of 1.8.  Baricitinib (neither dose) was associated with a higher risk of MACE (HR 1.06), all-cause mortality (HR 0.97), arterial thromboembolism (HR 1.27), or opportunistic infections (HR 1.25).   - Probiotics in Psoriatic Arthritis. (POS0290)    66 PsA patients randomized to receive either placebo or probiotic containing lactobacillus and bifidobacterium strains for 12 weeks.  This trial proves no significant effect with oral probiotic supplementation in PsA.  - CLE and smoking. Smoking reduces efficacy of antimalarials & worsens dz activity & damage. Advocate for smoking cessation! @Rheumnow #EULAR2026 https://t.co/pEWLJAkBAJ - Risk of Psoriasis is increased 19% by long-term exposure to Particulate Matter (PM2.5 & PM10; adjHR 1.19), while short-term exposure increases risk of psoriasis exacerbation (adjusted OR 1.03). Stronger in younger, urban, lower SES, ever-smokers, & comorbid allergies https://t.co/pd6S13RG1B

Kristi Spence and Patrick from Outrageous Insight chat with Andy Coutant, the former VP of Product at The North Face. We discuss culture, corporate turnarounds, ice climbing and much more. A fascinating conversation. #EarnDelight

Zach Miller is one of the greatest, most entertaining, and most thoughtful runners of his generation. It's a treat to have him in the studio ahead of Western States, a race he has patiently waited to run for over a decade.Miller is coming off a memorable 2nd place golden ticket performance at the Canyons 100K, a race where he reunited with Hayden Hawks for yet another classic duel in their storied rivalry, which dates back to the 2016 TNF 50 in San Francisco.We also catch up with Zach on other topics, including his regular IRunFar column, his trusty North Face hat, and his reflections on this stage of his career as a professional ultra-trail runner.Partners:Precision Fuel and Hydration - use code SINGLETRACK at checkout for 15% off your next orderNorda - check out the 005: the lightest, fastest, most stable trail racing shoe ever madeRaide - Making equipment for efficient human-powered movement in the mountains Support the show

In this episode of THE MENTORS RADIO, Host Dan Hesse talks with NFL Commissioner Roger Goodell, who, in two decades as Commissioner, has built the NFL into a sports, media and cultural leader—growing the NFL to be not only America's, but the world's top sports league, with 13 of the world's 20 most valuable teams being NFL teams. Ninety-three (93) of the top 100 rated programs on American television were NFL games. Starting as an intern for Commissioner Pete Rozelle in the early ’80s, Roger became the league's first Chief Operating Officer, and he succeeded Commissioner Paul Tagliabue as Commissioner in 2006. Roger has focused on strengthening the game for players and fans alike. He prioritized improving player health and safety through new rules and better equipment, driving down concussions and other major injuries. Under his leadership, the NFL has secured consecutive, ten-year transformative collective bargaining agreements with the NFL Players Association, allowing the league to grow and thrive, enhancing pay and benefits for current and retired players and ensuring decades of labor peace. In 2021, he negotiated long-term media agreements with CBS, ESPN/ABC, FOX, NBC and Amazon, which brought Thursday Night Football to a streaming platform for the first time. He has since spearheaded groundbreaking deals with YouTube for NFL Sunday Ticket and Netflix for the NFL's Christmas games, reaching a generation of younger fans. Under Roger's leadership, an increasing number of regular-season games are played outside of the US, and he's supported the rise of flag football globally. He also moved the NFL Draft from New York to cities and fans across the country. SHOW NOTES: ROGER GOODELL: BIO: BIO: Roger Goodell https://en.wikipedia.org/wiki/Roger_Goodell  BOOKS: Every Day is Sunday, by Ken Belson The Biography of Roger Goodell, by Christopher Mateo

Wouldn't you trade it all to just watch the Browns and Titans play on Thursday Night Football right now? Also, Shane covers the NY Jets! Hosted on Acast. See acast.com/privacy for more information.

Lion’s Mane Mushroom and Brain Health: What Four Clinical Trials Actually Found Many stroke survivors and people managing cognitive decline more broadly eventually ask the same question: Is there anything beyond physiotherapy and medication that can actively support brain healing? Not symptom management. Actual repair. Lion’s Mane mushroom (Hericium erinaceus) is one compound that has gathered genuine clinical attention. It is not a cure, the human trial evidence is still limited in scale, and it is not a replacement for the fundamentals of brain health. But the mechanism is unusual, the safety profile is consistently good, and for anyone serious about their brain, the research warrants an honest look. Why Lion’s Mane Is Neurologically Unusual Most supplements that claim to support brain health cannot cross the blood-brain barrier, the tightly regulated membrane that controls what enters the brain. Without crossing it, any direct effect on brain tissue is limited. Lion’s Mane contains two families of bioactive compounds found almost nowhere else in nature. Hericenones come from the fruiting body, the visible mushroom. Erinacines come from the mycelium, the root-like underground network. Both stimulate the production of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These are proteins the brain uses to grow new neurons, maintain existing ones, and strengthen the connections between them. Crucially, erinacine A, one of the key mycelium compounds, has been confirmed in preclinical studies to cross the blood-brain barrier. That is not a trivial distinction. It is one of the reasons researchers have taken this mushroom seriously. “These are proteins your brain uses to grow new neurons, maintain existing ones, and build and strengthen the connections between them. They are, in a very real sense, your brain’s repair and maintenance crew.” — Bill Gasiamis What the Human Clinical Trials Found Four published human clinical trials have examined Lion’s Mane. Here is what each found: Mori et al. (2009): In a randomised, double-blind, placebo-controlled trial, 30 older adults with mild cognitive impairment (MCI) took Lion’s Mane supplement or placebo for 16 weeks. The Lion’s Mane group showed significantly better cognitive function scores at weeks 8, 12, and 16. When supplementation stopped, scores declined again within four weeks, suggesting the effect was tied to ongoing intake, not a placebo response. Saitsu et al. (2019): A multicenter RCT tested 12 weeks of oral Lion’s Mane in older adults. Participants in the treatment group showed significant improvement on the Mini-Mental State Examination (MMSE) compared to placebo. No adverse effects were observed. Nagano et al. (2010): A 4-week RCT using Lion’s Mane-enriched cookies found significant reductions in self-reported depression and anxiety in women compared to placebo, suggesting effects extend beyond cognition to mood and emotional regulation, possibly via the gut-brain axis. Docherty et al. (2023): A double-blind pilot study from Northumbria University tested 41 healthy young adults aged 18–45. After a single dose, participants performed significantly faster on the Stroop task, a measure of cognitive processing speed and flexibility. After 28 days, there was a trend toward reduced subjective stress. This was a small study, and results should be interpreted cautiously, but it suggests Lion’s Mane effects are not limited to populations already experiencing cognitive decline. The Stroke-Specific Preclinical Data For stroke survivors, the preclinical research adds another dimension. In a 2014 animal study, erinacine A reduced brain infarct volume by 22–44% in ischemic stroke models (depending on dose), and significantly lowered pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α markers of the neuroinflammatory cascade that follows stroke. A 2022 study found that erinacine A helps preserve glutamate clearance in the brain after ischemic injury. Excess glutamate is one of the key mechanisms of neuronal death after stroke, so anything that helps regulate it post-injury is clinically relevant. These are animal studies. They do not translate directly to human outcomes. But they provide a biological rationale that supports why clinical researchers are now investigating Lion’s Mane in neurological recovery contexts. What the Research Does Not Yet Tell Us The limitations matter, and any honest assessment must include them. All four human trials are relatively small, none exceeds 100 participants. We do not yet have large-scale, long-term RCTs in stroke survivor populations specifically. The optimal dose, duration, and form (fruiting body vs mycelium vs dual extract) have not been established in human trials. Direct confirmation that erinacines cross the blood-brain barrier in humans rather than in animal models does not yet exist. Bill says it directly in the video: “The human trial data is still relatively limited in scale. We need larger, longer trials.” Practical Questions to Raise with Your Doctor If you are considering Lion’s Mane supplementation, the following questions are worth raising with your neurologist or GP: Is it safe alongside my current medications? Theoretical interactions exist with anticoagulants (warfarin, aspirin, clopidogrel) and antidepressants, not confirmed in human trials, but worth disclosing. Anyone on blood thinners following a stroke should have this conversation before starting. What form should I look for? Products should specify standardised hericenone content (fruiting body extract) or erinacine A content (mycelium extract). Products listed only as “mycelial biomass on grain” typically contain very low levels of active compounds and high levels of starch from the growth substrate. If the label does not specify active compound content, treat that as a quality flag. Are there any trials I could join? ClinicalTrials.gov lists current recruiting studies for Hericium erinaceus and cognitive function worth checking if you are interested in contributing to the evidence base. More information: https://recoveryafterstroke.com/book | Support the podcast: https://patreon.com/recoveryafterstroke *This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. The post Can a Mushroom Help Your Brain Heal? The Science Says Maybe appeared first on Recovery After Stroke.

The 2026 NFL schedule is officially locked in, and for the Carolina Panthers, it's time to have an honest conversation. Dave Canales and Dan Morgan have spent the offseason completely reshaping this roster — bringing in Jaelan Phillips, Devin Lloyd, and a rebuilt offensive line — but none of that matters until we see it tested against the best competition the league has to offer. And this schedule? It is going to find every crack in this team.In this video, we break down the six hardest games on Carolina's 2026 calendar, ranked from most brutal to most manageable, and explain exactly why each one is a genuine danger game.We start with the undisputed nightmare: Week 8 at Lambeau Field on Thursday Night Football. A short prep week, freezing late-October temperatures, and Jordan Love picking apart a secondary with limited practice reps is about as bad as a scheduling draw can get. Then there's Week 11, when Lamar Jackson and the Baltimore Ravens come to Bank of America Stadium for what promises to be the single greatest test of Carolina's new-look front seven. If Devin Lloyd and Trevin Wallace can't handle the run-fit responsibilities against Baltimore's heavy personnel, this one gets ugly fast.The prime-time slate doesn't stop there. Week 4 brings Dan Campbell's Lions to Charlotte for Sunday Night Football — a pure trench war that will tell us immediately whether Carolina's interior can compete with the best offensive line in football. Derrick Brown and second-round pick Lee Hunter are going to be pushed to their absolute limits. Week 6 puts the Panthers on the road in Philadelphia, coming straight out of their bye week into one of the loudest, most hostile environments in pro sports — Jaycee Horn in a heavyweight boundary battle against A.J. Brown and DeVonta Smith all afternoon.Then comes the back half of the season. Week 12 sends Carolina to Tampa Bay on Monday Night Football, where Todd Bowles will dial up every disguised pressure in his playbook specifically designed to confuse Bryce Young. And Week 16 closes the gauntlet in Pittsburgh, where single-digit wind chills, T.J. Watt on the edge, and real playoff implications will make for the grittiest afternoon of the entire season.Each of these games represents not just a tough opponent, but a specific schematic challenge that will expose something about who the Panthers really are in 2026. Can Bryce Young operate on short weeks in hostile prime-time environments? Can the new-look pass rush win on the road? Does this defensive front have the discipline to hold up against elite run games? The answers are all inside this schedule.If you love Panthers football and want the full breakdown of what's coming, you're in the right place. Like the video, drop your predictions in the comments below, and subscribe so you don't miss a single breakdown all season long.Let's ride, Panthers fans. Keep Pounding.

Description: Do you wonder if TB testing is needed when on a biologic for psoriasis and/or psoriatic arthritis and why? Hear the answer to such questions and more from dermatologist Dr. G. Scott Drew as he addresses recent recommendations.           Join host Archie Franklin as he discusses the latest recommendations from NPF and the International Psoriasis Council about routine testing for tuberculosis (TB) with treatments for psoriasis and psoriatic arthritis such as TNF-inhibitors, IL-17's, IL-23's and others with NPF Medical Board member and leading dermatologist Dr. G. Scott Drew from Mid-Ohio Dermatology.    This episode identifies when a screening for tuberculosis (TB) is needed based on the type of treatment for psoriasis and psoriatic arthritis given recent recommendations from the National Psoriasis Foundation and the International Psoriasis Council.    Timestamps:   (0:00)        Intro to Psoriasis Uncovered & guest welcome dermatologist Dr. G. Scott Drew.                                                                                          (1:00)         What is tuberculosis (TB) and why testing is required with TNF-alpha inhibitors.                                                                                  (4:22)         Frequency of testing for TB and if false positive results occur.                                                                                                                      (6:15)         Do other immunosuppressants require TB testing?                                                                                                                                            (8:14)         Testing may create barriers to access or unnecessary testing.                                                                                                                          (11:03)       Release of new recommendations from the IPC and the NPF Medical Board offering  guidance of when to test for tuberculosis                          prior to and during treatment of psoriatic disease.                                                                                                                                          (15:37)       No longer need to wait to start therapy like the IL-17's or IL-23's to see the impact on quality of life.                                                      (18:26)       TB recommendations for other targeted medications like JAK inhibitors, PDE4, or the new oral IL-23 agent.                                  (19:15)        Implications of the recommendations for clinical trials.                                                                                                                                (20:13)        Become a member of NPF and visit the website to access resources and stay aware of the latest information impacting the care                       and treatment of psoriasis and psoriatic arthritis.  Key Takeaways: ·       Due to the contagious nature of tuberculosis, a mycobacteria infection that affects the lungs and other parts of the body, and the increased risk associated with suppressing TNF-alpha, a TB screening is required prior to initiating and during some treatments for psoriasis and psoriatic arthritis.   ·       With more advanced and targeted psoriatic disease treatments now available, the National Psoriasis Foundation and the International Psoriasis Council joint position statement recommends that TB screening is no longer needed with use of IL-17 or IL-23 treatments.    ·       TB screening may still be appropriate for specific populations and when symptoms are present based on a clinician's assessment. Guest Bio: Dr. G. Scott Drew is a medical and surgical dermatologist with Mid-Ohio Dermatology Associates where he specializes in inflammatory diseases such as psoriasis, believing strongly in dermatology and patient care. He is board certified in both Dermatology and Family Practice. In addition to his clinical practice, Dr. Drew is a member of the clinical faculty at Ohio State University, College of Osteopathic Medicine and participates in multiple dermatologic research protocols at five locations in central Ohio. He has been published in numerous peer-reviewed journals, contributed to scientific symposia, and authored textbook chapters. Dr. Drew is a fellow of the American Osteopathic College of Dermatology and the American Academy of Dermatology, he is past president of the Marion Academy of Medicine, a member of the American Osteopathic Association, and is a member of the National Psoriasis Foundation's Medical Board contributing to the development of guidelines and consensus statements. He is passionate about education providing lectures both nationally and internationally on medical, surgical, and cosmetic dermatology. Resources: Joint position statement from the National Psoriasis Foundation Medical Board and the International Psoriasis Council on routine testing for latent tuberculosis infection prior to and during treatment of psoriasis patients with interleukin 17 or interleukin 23 inhibitors. Journal of the American Academy of Dermatology. Vol . 94/3; P802-809. March 2026.

Guest: Dr. Shabaana Khader is a Professor and Chair of the Department of Microbiology at the University of Chicago. She discusses how the immune system responds to Mycobacterium tuberculosis, why tuberculosis remains one of the world's deadliest infectious diseases, and the challenges of developing more effective vaccines. She highlights the role of lung-resident immunity, including Th17 responses and lymphoid structures, in controlling infection, and explains how advances in our understanding of host–pathogen interactions are guiding the design of next-generation TB vaccines. Featured Products and Resources: Learn about STEMCELL’s optimized protocols and reagents for immunotherapy research. Download a free Nature Reviews Immunology T cell nomenclature wallpaper. The Immunology Science Round Up Personalized HPV Cancer Vaccine – A multifunctional nanovaccine combining HPV antigens, tumor membranes, and bacterial adjuvants generates durable anti-tumor immunity against HPV-associated cervical cancer. HIV Rewires T Cell Identity – HIV can reprogram infected CD4+ T cells into CD8+ T cells, revealing a previously unrecognized component of the viral reservoir. Decoding Acute Pancreatitis – A single-cell atlas of severe acute pancreatitis identifies a TNF-α–driven immune-endothelial circuit that causes microvascular failure and disease progression. Discovery of Ruptoblasts – A newly discovered cell type, the ruptoblast, protects planarians through an explosive cytotoxic mechanism termed ruptosis. Image courtesy of Dr. Shabaana Khader Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Deb 00:00:01Imagine your body has a repair manual, instructions written in your cells that tell tissues how to heal, blood vessels, how to grow, and inflammation when to stop. But what if those instructions got lost somewhere along the way? Well, today I’m talking about peptides, tiny protein fragments that act like biological text messages. Two of them, BPC 157 and TB 500.They’re showing remarkable promise for gut repair, joint recovery, and tissue regeneration. But here’s what nobody’s telling you. Women respond differently to these healing signals, especially during hormonal transitions. And today, we’re uncovering the science behind these regenerative peptides, who actually needs them, and why your doctor might not know about them. Can you guys put our ad right in here and then I’ll go to the standard intro?Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb, your medical detective. And today we’re diving into regenerative peptides BPC157 and TB 500. If you or someone you love is struggling with slow recovery from injury, chronic joint pain, gut inflammation that just won’t quit, or you just feel like your body doesn’t bounce back the way it used to, this episode is for you. Grab a cup of coffee or tea or whatever helps you unwind, settle in, and let’s start you on your journey to deeper healing. We’ll do another sponsor break here. Deb 00:01:52So let’s start with the question I hear constantly in my practice. Dr. Deb, I’m doing everything right. I’m eating clean, I’m exercising, I’m taking my supplements, but I’m still not healing. What am I missing? Well, that answer might surprise you. Sometimes it’s not about what you’re putting in your body. It’s about whether your cells are actually receiving the repair signals they need. That’s where peptides come in. Think of peptides as The body’s original communication system. These short chains of amino acids are like biological post-it notes carrying instructions from one cell to another. They tell your human system when to calm down, your blood vessels when to grow and your tissues when to repair. Now here’s where it gets interesting for women specifically. We know that estrogen plays a massive role in collagen production, vascular health, inflammatory response. When estrogen starts declining, whether that’s perimenopause, postpartum, or even from chronic stress, our natural repair mechanisms slow down dramatically. You might notice it as my joints are aching more, I’m a little more fluid filled, you know, they hurt when I bend them, my injuries take twice as long to heal.Gut issues that suddenly appear out of nowhere and no matter what you do, they don’t seem to repair. Skin has lost its elasticity or just this general sense that your body isn’t keeping up anymore. This is where BPC 157 and TB 500 entered the picture. So BPC 157, short for body protection compound 157, is a naturally occurring peptide sequence found in your gastric juices. And according to a 2024 systemic review published in emerging use of BPC 157 in orthopedic sports medicine, this peptide promotes something called angiogenesis. That’s the formation of new blood vessels and they deliver oxygen and nutrients to damaged tissues. Now TB 500 is a synthetic fragment of thymus and beta-4. Deb 00:04:17A protein your body makes naturally during wound healing and research published in therapeutic peptides in orthopedics in 2025 shows that it works like a cellular first responder rushing to injury sites and coordinating tissue repair through a process called actin regulation. But here’s what makes these peptides different from just taking another supplement. They don’t force your body to do anything.They simply remind yourselves how to heal the way they used to. And for women navigating hormonal changes, autoimmune flares, chronic inflammatory conditions, that distinction matters enormously. all right, let’s get into some of these mechanisms because understanding how something works helps you make informed decisions about whether or not it’s right for you. So,Let’s look at the science. Do these peptides actually work? And if so, how do they work? Let’s start with BPC 157. This works through multiple pathways simultaneously. First, it activates growth factor receptors that stimulate fibroblasts. Those are the cells responsible for making collagen and rebuilding connective tissue. And according to research published in Frontiers and Pharmacology in 2023, titled Regeneration or Risk, BPC 157 also modulates nitric oxide signaling, which enhances vascular repair and reduces oxidative stress at the cellular level. So this is really important because many of us are nitric oxide deficient, especially as we get older, especially since the pandemic, we’re seeing a lot of people being more deficient in nitric oxide and you’re taking nitric oxide, many of you, to help with this process. But if we’re having other issues that don’t allow that nitric oxide to get where it needs to go, that could render it completely useless. So in plain English, when we’re talking about how BPC 157 helps the blood vessels work better and protects your mitochondria, big word for your energy factories and your cells from that inflammatory damage. Deb 00:06:38Now there’s studies in musculoskeletal and gastroenterology models that show BPC157 decreases inflammatory cytokines like TNF-alpha and IL-6. And these are chemical messengers that keep inflammation turned on. So by dialing them down, BPC157 creates an environment where healing can actually happen. Now, where do we know about this?TNFL and IL-6, well, we know it from viruses, we know it from Lyme disease, we know it from mold toxicity. These cytokines are turned up, they’re creating a massive inflammatory response in the body, and you’re struggling to get these things down because of that or potentially other reasons. So here’s where it gets really interesting with women in perimenopause or menopause. When estrogen declines, collagen synthesis slows down. And that’s why we see increased joint pain, slower wound healing, and our changes in the skin’s elasticity during this transition. We see the little wrinkles, the fine lines, we see the subcutaneous fat going away a little bit more. This is partially why this is occurring. And so from research shown in the Journal of Orthopedic Research in 2023 by Leibowitz and colleagues, that they suggest that BPC157 affects on the endothelial layers. So the cells lining the blood vessels and these may mimic some of the estrogen’s protective vascular effects without actually affecting your hormone levels. This is really huge because we know that as women lose estrogen, they have a higher risk for vascular events, heart attack, stroke, things like that. And if people have already had a heart attack or a stroke, We typically recommend that they don’t use estrogen because that could potentiate the risk for another heart attack or a stroke. But that means that you don’t gain the benefits of estrogen either. So if we think about this, we could potentially use BPC 157 to give us some of the benefits that we lost from having estrogen and potentially not being able to use estrogen. And that would be huge for us. Deb 00:08:57And not to mention the reduction of inflammation and the joint pain and the wound healing and the energy and the gut feelings. I mean, there’s just so many benefits to BPC 157 that we could talk about them all day long. But we’ve got to move on. So let’s talk about TB 500. Now this peptide works very differently. Its primary job is promoting cell migration, essentially telling repair cells to go to this spot and what to do when they get there. So it sends a signal, puts a little post-it stamp there and says, Hey, when you get there, fix A, B, C, and D. And there was a study in 2024 in cell biology international that demonstrated that TB 500 increases epithelial closure and improves tendon elasticity in models of repetitive strain injury. So let’s think about that a little bit. What does that really mean?That means faster recovery from exercise induced muscle damage, better healing of overuse injuries like tennis elbow or plantar fasciitis, improved scar tissue remodeling after surgery or a C-section, enhanced recovery from chronic inflammatory conditions affecting soft tissues. And I’ve talked about this several times. I have used these compounds post-surgical personally.And I remember going back to see my surgeon at the two to three week mark for follow-up. And she was amazed at how well everything was healing. And when I asked her if she wanted to know what I was doing, her response was no, but keep doing whatever you’re doing because it’s working. And after three weeks of a major pelvic repair surgery that I had, four hours in surgery, lots of sutures, not comfortable. I was actually walking a mile and didn’t have pain and I was recovering really well and felt amazing. And that is just not typically heard of in surgical procedures like mine. It’s usually a minimum of a six to eight week recovery before you’re starting to do that again. And I give all of the credit to these two peptides. Deb 00:11:17In my clinical practice, I see this play out constantly. Women who train hard, whether that’s CrossFit, running, yoga, or just trying to keep up with active kids, often hit a wall where their recovery can’t keep up pace with their activity level. And TB 500 helps to bridge that gap by optimizing the body’s natural repair timeline. But here’s what I want to emphasize with you. These peptides aren’t magic bullets.They work best when we combine them with proper nutrition and anti-inflammatory diet, adequate sleep, stress management, and we address the underlying root cause like the gut dysfunction or those hormonal imbalances. And they work much better when the hormones are balanced versus when they’re not. They’re amplifiers of your body’s existing healing capacity, not replacements for foundational health practices.So let’s have some real talk here. Let’s talk about evidence and what you need to know about that. Let’s take a drink, sorry. Now let’s address the elephant in the room. Regulatory status and safety. Neither BPC 157 or TB 500 are FDA approved for human medical use. They fall into a category called research compounds. And that means they’re legal to possess and use but they’re not approved as pharmaceutical drugs. And hopefully they will be back on our list of things to use relatively soon with the changes that Bobby Kennedy has made to peptides recently. So why does this matter? Because quality becomes a concern. Quality control is absolutely critical. You need to know where these compounds are manufactured, their source, their testing. their clarity, everything about them. There was a 2025 review in therapeutic peptides in orthopedics that concluded both peptides demonstrate strong regenerative signaling with minimal systemic side effects in preclinical studies. But, and this is really important, most of the robust data we have comes from animal models and cell culture models, not large scale human clinical trials. Deb 00:13:41Now that doesn’t mean that they don’t work. It just means that we are still in the early stages of understanding optimal dosing, treatment duration, and long-term effects in humans. So why do we have all of this great peptide information and we don’t quite have the ability to use them yet, or it’s extremely restricted?That comes under the guise of the FDA. came through the past administration with Biden where he removed a bunch of these peptides from the market. Both BPC and TB 500 were on the list of safe peptides to use before Biden made his changes. And it looks like they may be coming back relatively quickly for us here. So what we do have is growing clinical feedback from practitioners like myself. Who use these peptides in practice under careful supervision and under pilot studies on musculoskeletal recovery published in our organizations that we work with. So all of our information is documented and it is done under an observational study. There are other studies published in orthopedic and biomedical research from 2025.that actually found VPC-157 reduced pain scores by 35 % and improved functional mobility within eight weeks. This is really phenomenal because many people over the age of 40 are reaching for the Tylenol bottle, the Advil bottle, the Aleve bottle, which does a number on your kidneys and your gut and your liver. And it is really problematic to be using these things on a regular basis.And if we can use a compound that’s safe, that preserves the kidneys, the liver and the gut, why don’t we do that is the question that I have. Now, we see a lot of the same information in our clinic that we see in these studies. And it is the following things that we see. Significant reduction in joint pain and stiffness. I have a person that was looking at doing a knee replacement and we did 10 weeks of these two compounds. Deb 00:16:00And her knee pain reduced so much that she decided she didn’t feel like she needed that knee replacement right away, which is good because she is only 60 years old. And the length of that knee replacement wouldn’t be as long as it would if she could wait five or 10 years. The doctor didn’t say she needed to do it right away. She wasn’t that critical, but it was the pain that was driving her to the replacement. And so if we could preserve that and give her a reduction in pain, all the better to do that. We get faster recovery from surgical procedures, improved gut symptoms, especially in cases of leaky gut or inflammatory bowel conditions, better skin quality and wound healing, enhanced overall sense of resilience and recovery capacity. But here’s what you absolutely must know before considering peptide therapy. First, source matters. Because these aren’t FDA regulated pharmaceuticals, quality varies widely and you need to work with a physician who sources from compounding pharmacies 503A or 503B that provide certificates of analysis, third party testing and proper sterility verification. Secondly, context matters. Peptides work best as part of a comprehensive functional medicine approach. So if you’re still eating inflammatory foods, drinking alcohol, not managing your stress or your sleep, you have unaddressed gut dysfunction, and these peptides alone won’t fix those problems. Thirdly, realistic expectations matter. These aren’t overnight miracle cures. Most patients see gradual improvements over four to 12 weeks. Some respond dramatically, others see modest benefits. Individual variation is real. And fourth, medical supervision matters. Dosing, injection technique,monitoring for side effects and knowing when peptides are or are not appropriate. All of this requires clinical expertise. Now let me bust a few myths here because I hear this constantly. Myth number one, peptides are just for bodybuilders and athletes. That is false. While athletes use them for performance recovery, the therapeutic applications for chronic pain, gut healing and age related tissue decline are profound. Deb 00:18:26For everyday people. Myth number two, peptides will mess with my hormones. False. BPC-157 and TB-500 don’t interact with your endocrine system the way hormones do. They work through growth factors and cell signaling pathways. They are very different. Myth number three, if they’re not FDA approved, they must be dangerous. Not accurate.Many effective therapies exist in regulatory gray zones. What matters is quality sourcing, proper medical oversight, and informed consent. So the bottom line here is that these peptides show real promise backed by mechanistic science and growing clinical expertise, but they require responsible use, quality products, and realistic expectations. Now let’s talk about practical integration.Who should consider peptides? Well, so who actually benefits from the peptides? Let’s start there. Let me walk you through the three main categories I see. Number one is gut restoration. If you’re dealing with chronic gut inflammation, whether that’s IBS, inflammatory bowel disease, leaky gut, persistent digestive issues that haven’t responded to dietary changes alone, BPC 157 can be transformative.I had a patient recently, I’ll call her Sarah. She’s been struggling with severe gut pain and food sensitivities for three years. She tried elimination diets, probiotics, gut healing supplements, everything. And within six weeks of adding BPC 157 to her protocol, alongside the targeted nutritional therapy, her pain dropped by 70 % and she could tolerate foods that she hadn’t tolerated in years. Why does this happen? because BPC 157 directly supports mucosal integrity, the protective lining of your intestinal tract, and it reduces inflammatory cytokines and promotes healing of damaged tissue. Number two, muscle and joint recovery. This is where I see TB 500 shine. Women who are active, whether you’re a runner, a yogi, a cross-bitter, or someone who just wants to keep moving without pain. Deb 00:20:48They often hit a point where recovery becomes a very limiting factor. And maybe you’re dealing with chronic tendonitis, a nagging shoulder injury, a bad back that just will not quit, or just general achiness. It all makes you feel older and keeps you from being active the way you want to. TB 500 combined with therapies like red light therapy, PEMF, or targeted physical therapy, can dramatically accelerate soft tissue healing. I’ve seen recovery timelines cut in half for patients dealing with overuse injuries. Number three, menopausal transition support. This is where the intersection of peptides in women’s health gets really exciting. During perimenopause and menopause, declining estrogen affects collagen production, vascular health, and joint integrity, along with inflammatory processes and responses.Many women notice they just don’t heal as quickly and their joints hurt much more. Besides noticing their skin changes and their injuries linger longer. Low dose peptide protocols, often combining BPC157 for vascular and gut support with TB500 for soft tissue repair, can complement bioidentical hormone therapy or stand alone for women who can’t or don’t want to use hormones.Now I’m not saying that peptides replace your hormone optimization, but they can be powerful adjuncts that support tissue resilience during a time when your body’s natural repair mechanisms are shifting. Now, who should not use peptides? If you have any active cancer or a history of certain cancers, peptides that promote cell growth and angiogenesis might not be appropriate. If you’re pregnant or breastfeeding, we don’t have safety data.If you have severe kidney or liver disease, clearance and metabolism could be affected. You want to work with a practitioner who really understands this and be under medical supervision for these kinds of conditions. This really matters. A qualified functional medicine practitioner can assess your individual situation, run appropriate labs and determine whether peptides fit into your overall healing strategy. Remember, peptides are tools. They’re not magic. Deb 00:23:11They work best when you’re also addressing nutrition, sleep, stress, movement, and underlying root causes. They amplify your body’s healing capacity. They don’t replace the fundamentals. This is really important to understand. So thank you for joining me today on Let’s Talk Wellness Now. If this episode resonated with you, share it with another woman who’s ready to reclaim her body’s natural healing capacity. Remember, Wellness isn’t just about feeling good. It’s about thriving in every area of your life. Your body was designed to heal. You’re not a small version of a male. You are a woman with different biochemistry. And sometimes it just needs the right signals and the right support to remember how. If you’re ready to explore personalized regenerative medicine or peptide therapy as part of a comprehensive functional medicine approach,You can visit us at serenityhealthcarecenter.com. You can also follow us on Instagram, and you can look at my book, Seen at Last, and join the Seen at Last free community on Facebook, where we will provide all of this information and more for you. Until next time, I’m Dr. Deb, reminding you to take care of your body, mind, and spirit. Be well, and I’ll see you in the next episode.The post Episode 269 – Peptide Therapy for Women: How BPC-157 & TB-500 Heal Gut, Joints & Inflammation first appeared on Let's Talk Wellness Now.

从明星同款路标到赛事公仔，从“香山常客”飘带到宁海王者拖鞋——我们聊了聊那些让人忍不住"掏钱"的跑步周边。为什么一个路标能被粉丝追着买？赛事的“理财产品”到底值不值？听完这期，你可能也想翻翻自己的包上挂了啥。你将听到：1. 明星效应带火“周边”：演员刺鲨参与ACG活动，其专属路标和飘带被粉丝疯抢，甚至有人上山“寻宝”。一个路标，承载的是情绪价值和“偶像同款”的仪式感。2. 赛事周边=社交货币：宁海的王者公仔、环四的毛线牛角帽、帆布包——这些周边不仅是纪念品，更是跑友间的“接头暗号”。一个挂件，能让你在地铁里认出“自己人”。3. 好看＞实用？ 周边设计是下单的第一驱动力。北马周边被吐槽“不好看”，而宁海、环四的设计在线，即使价格偏高也愿意买单。4. “限定”才是硬道理：TNF小铃铛从稀有到人手一个后“祛魅”，证明了稀缺性才是周边升值的核心。5. 大本营周边剧透：帽子、T恤、软水壶正在路上！未来可能推出“会员专享款”，让你跑得更“有身份”。=======================微博 / 小程序 / 服务号 / 小红书：@跑者日历公众号： 跑者日历RUN365各音频及播客平台：跑者日历跑者日历播客矩阵：跑者日历/装备说/PB计划/跑圈速递/首百计划商务合作请添加微信号：janicegooner加入听众群：请添加客服微信号 paozherili

On this episode of Tiger-Cats Game Day, hosts Louie B and Mike Daly get you set for the Hamilton Tiger-Cats first road matchup of the season when they travel to Winnipeg to take on the Winnipeg Blue Bombers in Thursday Night Football.

Microplastics and Stroke Risk: What a Landmark 2024 Study Found Inside Human Arteries In 2024, a team of Italian researchers published a study in the New England Journal of Medicine that stopped the cardiovascular science community in its tracks. They found microplastics, tiny synthetic fragments embedded inside the carotid artery plaque of more than half the patients they examined. And the patients who had them faced more than four and a half times the risk of a serious cardiovascular event compared to those who didn’t. This isn’t a distant, theoretical risk. These are living people who had already been identified as having carotid artery disease, and plastics were found inside their arterial walls. For stroke survivors and those at elevated risk of stroke, this study raises important questions that the medical system has not yet caught up with. What the Research Found The study by Marfella et al., published in the New England Journal of Medicine (2024), enrolled 304 patients who were undergoing carotid endarterectomy, a surgical procedure to remove plaque from the carotid arteries. Researchers analysed the excised plaque for the presence of microplastics and nanoplastics. Their findings: 58% of patients had detectable levels of polyethylene, polyvinyl chloride (PVC), or polystyrene in their arterial plaque. This was not contamination from the surgical procedure; it was already there. Over a 34-month follow-up period, patients with microplastics in their plaque had a 4.53 times higher risk of a combined endpoint: non-fatal myocardial infarction, non-fatal stroke, or death from any cause. Inflammatory markers were significantly elevated in the microplastics-positive group. IL-18 and TNF-alpha proteins associated with systemic vascular inflammation were markedly higher in plaque samples that contained plastics. This suggests the mechanism is not simply physical obstruction, but an inflammatory cascade triggered by the presence of synthetic material in arterial tissue. What This Means for Stroke Survivors The carotid arteries are the primary conduits supplying oxygenated blood to the brain. Plaque accumulation in these vessels is one of the leading causes of ischaemic stroke, and carotid artery disease is a condition many stroke survivors are already living with. “The patients with microplastics in their plaque had a 4.53 times higher risk of stroke, heart attack, or death over the 34-month follow-up. That’s not a marginal finding. That’s a signal the research community needed to take seriously.” The NEJM study doesn’t yet tell us whether removing microplastic exposure after the fact reduces risk. It doesn’t confirm that healthy individuals with no existing carotid disease are accumulating plastics at the same rate. And it cannot tell us which plastic sources are most responsible because we’re exposed to microplastics through drinking water, food packaging, air, and a dozen other vectors simultaneously. But what it does tell us clearly and with high statistical significance is that microplastics in arterial plaque are associated with dramatically worse cardiovascular outcomes. What the Research Does Not Yet Tell Us Science at the frontier moves in one direction at a time. This study establishes association, not causation. It cannot yet answer: Whether people without existing carotid disease are accumulating microplastics at comparable rates. Whether reducing exposure actively reverses or slows plaque-associated risk. Which types of microplastics are most biologically harmful? Whether there will be a clinical screening tool for this in the near future. These are the questions the next generation of research will need to answer. In the meantime, it’s reasonable to act on what we do know. Practical Steps to Reduce Exposure No clinical screening currently exists for microplastics in arterial plaque. There is no blood test, no imaging, no biomarker that your GP can order today. What you can do is reduce your ongoing exposure, particularly through food and water contact with plastics. Evidence-informed steps worth discussing with your treating team: Use glass, stainless steel, or ceramic containers rather than plastic for food and drink storage. Avoid microwaving food in plastic containers; heat accelerates the leaching of plastic particles. Filter your drinking water; some filters (carbon block and reverse osmosis) reduce microplastic levels significantly. Reduce consumption of highly processed foods in plastic packaging. Bring this study to your vascular neurologist, cardiologist, or GP and ask whether it’s relevant to your personal risk profile. This is not a recommendation to take a supplement or start a treatment. It’s an invitation to have an informed conversation with the people responsible for your care using the best available evidence. If you found this useful, my book walks through the science of stroke recovery in the same evidence-first, no-hype way. Find it at recoveryafterstroke.com/book. Want to go deeper and support the channel? Join the community at patreon.com/recoveryafterstroke. The post Plastics in Your Arteries: The Stroke Risk Study You Must Know appeared first on Recovery After Stroke.

Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.

Chronic inflammation is silently driving some of the most common diseases today — and most people have no idea it's happening. In this episode, Nurse Doza breaks down five hidden triggers: poor sleep, refined grains, low vitamin D, omega-3 deficiency, and digestive issues — and exactly what you can start doing about each one today. FEATURED PRODUCT Liver Boost – MSW Nutrition Chronic inflammation doesn't just live in your joints or your gut — your liver is at the center of it all. The liver filters inflammatory byproducts, processes environmental toxins, manages hormones, and supports fat digestion. When it's overburdened, your inflammatory load goes up. Liver Boost from MSW Nutrition is formulated with N-acetyl-L-cysteine (NAC), milk thistle, and selenium to support liver detoxification, protect your antioxidant defenses, and ease the total burden your body is carrying — making it a natural complement to everything discussed in this episode.

Buffalo Bills reporter Sal Capaccio stops by The Sports Bar to share the latests out of Bills OTAs.

Vinnie Dombroski of Sponge joins us, Eli Zaret in studio with a Pistons post-mortem, Rolling Stone's Greatest Punk Albums, Jason Biggs gets hot & dumps wife, and Meghan Markle delivers an AI speech in Geneva. Eli Zaret drops by the studio to recap the Detroit Pistons Game 7 loss to the Cleveland Cavaliers, Netflix steals TNF, hot takes on Ronda Rousey vs Gina Carano, discuss the floundering Detroit Tigers, preview the Detroit Lions 2026 season schedule, Tom Brady's modeling career, the WNBA's odd marketing strategy of eliminating Caitlin Clark, Cal Raleigh's superstitions, and more. Trudi Jasina's into the show. Mojo in the Morning had to be educated by Bark Nation over a joke. There is still time to donate to Thomas Markle. Jason Biggs and his wife have divorced… because he lost weight. Pete Davidson is an absentee father and terrible with money. Brad Pitt's children hate him and won't use his last name. Rolling Stone with their list of The 100 Greatest Punk Albums of All Time. Luigi Mangione has some evidence scrubbed in his case. Chicks still dig him. Wade Wilson, the Deadpool Killer, thinks he's hot. Every prison inmate in California needs an iPad. Zach Galifianakis tends to a garden these days. Vinnie Dombroski and Sponge will be rocking Rock & Brews in Royal Oak on THURSDAY, 5/21. Vinnie joins us using technology. Meghan Markle blabbed away in Geneva, Switzerland to 40 people. People Magazine continues to shill for that beast. RIP Mark Fuhrman. Eddie Kramer and Rick Beato collab. We remember the great Red's Tube Bar calls. Merch is for sale! Buy it. Or don't. But do. If you'd like to help support the show… consider subscribing to our YouTube Channel, Facebook, Instagram and Twitter (Drew Lane, Marc Fellhauer, Trudi Daniels, Jim Bentley, BranDon, and Roberto).

This episode of the Everyday Epigenetics: Raw. Real. Relatable. podcast takes a hard look at one of the biggest trends in the wellness world: detox culture. Susan Robbins shares a raw and deeply honest perspective on the fear-based messaging surrounding parasites, mold, heavy metals, cleanses, and “toxic overload,” while explaining what true detoxification actually looks like inside the body. From harsh protocols and supplement overload to the nervous system's role in health, this conversation challenges the idea that more detoxing always equals better wellness.Susan also dives into the genetics behind detox pathways, including MTHFR, COMT, PEMT, GST genes, inflammation markers, bile flow, and histamine responses. She explains why personalized health matters, why one-size-fits-all detox programs can backfire, and how stress, sleep, nutrition, circadian rhythm, and emotional safety often play a much bigger role in how the body functions than another cleanse ever will. This episode is a reminder that the body already knows how to detox when it has the right support, nourishment, and stability.In this episode:Why the detox industry often profits from fearThe difference between true toxic overload and depletionHow the body naturally detoxifies through the liver, kidneys, gut, skin, and lymphatic systemWhy harsh cleanses can create more stress on the bodyThe truth about parasite cleanses, binders, colonics, and juice detoxesHow chronic stress impacts detox pathways and hormone balanceWhy genetics like MTHFR, COMT, GST, PEMT, IL6, and TNF-alpha matter in personalized healthThe connection between histamine, sulfur pathways, glutathione, and detox symptomsHow nervous system regulation impacts healing and detoxificationWhy lifestyle rhythms, sleep, meal timing, and stress management matter more than most people realizeHow Susan uses epigenetics and PH360 health types to personalize detox supportThe importance of building resilience instead of living in fear around healthRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/05/18/episode124/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

The NFL Schedule dropped this past Thursday so we officially have a week-to-week breakdown to go over for the 2026 Bills season! Josh & Luka are back to give their initial thoughts about everything that is this Bills schedule as we sit here in mid-May. How we feeling about the New Highmark Stadium opener being on Thursday Night Football in week 2? Is opening the season at the Houston Texans actually a good thing? What is up with the Bills ending up on both Thanksgiving night hosting the Chiefs AND being on the road to take on the Broncos Christmas night?? All that & more on this week's Bills Chat Podcast!

Can Stroke Recovery Happen Years Later? The Griffith University Etanercept Trial Answers If you caught my recent video about UCLA's discovery of the first stroke rehabilitation drug that rebuilds brain connections in mice, you know the incredible excitement it generated. If you missed it, the link is in the description below. It's definitely worth a watch. Because of the huge response and the many messages from stroke survivors asking for more real recovery options, I wanted to take a deeper look at another breakthrough: The Griffith University study on using a drug called etanercept to help stroke survivors, not just weeks after a stroke, but even years later. And trust me, the results are eye-opening. Today, I'll walk you through what the study found, how it was set up, what it means for all of us, and where things are heading next. What Was the Study About? Researchers at Griffith University in Australia asked a bold and important question: Can etanercept help stroke survivors still living with chronic pain and movement problems, even many years after their stroke? They weren't looking for tiny improvements – they wanted to see fast, meaningful, life-changing results. This study wasn't designed for people who have just left the hospital. It was for survivors who had had their strokes at least six months ago, with some having had strokes over 15 years earlier. Why Did They Do It? Chronic post-stroke pain, or CPSP, is one of the most devastating outcomes of a stroke. It's not just muscle pain. It's deep nerve pain, constant, burning pain that regular medications like oxycodone or pregabalin often can't touch. Researchers now understand that this ongoing pain is often caused by inflammation in the brain, specifically driven by a chemical called TNF-alpha. Etanercept is a drug that's been used safely for over 20 years to treat arthritis and autoimmune conditions because it blocks TNF-alpha. The Griffith team wanted to test whether using etanercept to block brain inflammation could unlock recovery, even years after a stroke. How Was the Trial Set Up? This wasn't a casual or loose experiment – it was a carefully designed, professional clinical trial. Here's how it worked: 26 stroke survivors participated. Ages ranged from 30 to 80 years old. Strokes had occurred 6 months to 15 years earlier. Every participant had moderate to severe daily pain (rated between 4 and 8 out of 10). All had hemiparesis, or weakness on one side of the body. Participants were randomly assigned to one of two groups: One group received etanercept injections. The other group received placebo injections (just sterile saltwater). Each person received two treatments: One on Day 1 Another on Day 14 The injections were given near the neck in the perispinal space, allowing the drug to travel quickly to the brain. What Were They Measuring? The researchers focused on solid, measurable outcomes: Pain levels – using a 0–100 scale combined with a faces pain chart. Shoulder movement – measuring how far participants could lift their weaker arm. Sensation – testing for improvements in feeling hot, cold, and pressure. Cognition and fatigue – although big changes weren't expected here. Participants were monitored closely for 30 days after their first injection. What Happened? Here's what the trial revealed: Pain Relief 70% of the participants in the etanercept group experienced significant pain improvements. Pain levels dropped by an average of 24 points out of 100. 3 out of 10 participants experienced near-complete pain relief — often within 30 to 60 minutes of their first treatment! Meanwhile, the placebo group showed almost no change. Mobility Gains 9 out of 10 participants in the etanercept group regained more shoulder movement. 6 regained at least 60 degrees of motion. 3 participants fully regained 180 degrees — meaning full overhead shoulder motion. Sensory Improvements Many participants began to feel heat, cold, and pressure better on their affected side — a strong sign that nerve function was returning. Side Effects Only one major side effect was reported: one participant developed shingles and had to withdraw from the study. No other serious adverse events were recorded. What Does It Mean? If these results hold up in larger, longer studies: Stroke survivors could have a real option for reducing chronic pain and restoring lost movement. It could dramatically lower reliance on heavy opioid medications. Most excitingly, it shows that the brain may still be capable of healing years after a stroke — if inflammation is correctly targeted. However, it's important to remember: This was a small trial. Etanercept is not yet officially approved for stroke recovery. And the treatment doesn't work for everyone. But it's a huge, hopeful step forward. A Word About Dr. Tobinick It's important to acknowledge someone who helped make all this possible: Dr. Edward Tobinick. Dr. Tobinick was the first to use perispinal etanercept for stroke survivors back in the early 2000s. He was featured on 60 Minutes Australia in 2011, showing stunning recoveries that few thought were possible. Despite facing skepticism, lack of pharmaceutical company support, and high treatment costs, Dr. Tobinick kept pushing forward. Without his work, many stroke survivors wouldn't even know this therapy existed. You can find the link to that original 60 Minutes interview in the description. What's Next? Because of all the interest from our community, I'm reaching out to researchers at the Florey Institute in Australia. They’re currently working on new therapies for stroke recovery, and I'll update you on: Where their research stands What new options might become available And how close we are to real-world treatments for stroke survivors Stay tuned, as soon as I hear back, I'll share everything with you. Want to Dive Deeper? If you’d like to read the full Griffith University study, the link is in the description. The brilliant researchers behind this study include: Dr. Stephen J. Ralph Dr. Andrew Weissenberger Dr. Ventzislav Bonev Dr. Adrienne Goodman-Jones, and others from Griffith University and partner institutions. They deserve real recognition for pushing this research forward. Final Thoughts If you found this article helpful, Please subscribe, comment, and share this post with someone who might need hope today. And if you're listening on Spotify or Apple Podcasts, please leave a review. It helps more stroke survivors find this channel and this growing community. The post Etanercept and Stroke Recovery: Breakthrough Griffith Trial Results You Need to Hear appeared first on Recovery After Stroke.

The 49ers got their 2026 schedule and there's a lot to unpack. We're going game by game — from the NFL's first ever game in Australia to a Sunday Night Football showdown in Mexico City to a late December home game against Kansas City. Who do they have rest advantages over? Where are the traps? Is the bye week placement a win? Full breakdown right here. S ign up for PrizePicks with code: HMA and get $50 in lineups instantly when you play your first $5+ lineup! https://link.prizepicks.com/LME0/DAMON  For advertising opportunities: contact@hogmedia.co  Support the show by becoming a member: https://www.youtube.com/channel/UCcs13VXhiObJg6jGDw2xbZg/join  All Damon Bruce Plus content is available on your favorite podcast platform: https://pod.link/1681177856. #49ers #NFLScheduleRelease #SanFrancisco49ers #NFLSchedule2026 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The NFL dropped the full 2026 schedule and the rest advantages, short weeks, and brutal road stretches are already telling a story. We're breaking down the biggest winners and losers from a pure scheduling luck standpoint — who's set up for a run and who's already playing from behind.  Sign up for PrizePicks with code: HMA and get $50 in lineups instantly when you play your first $5+ lineup! https://link.prizepicks.com/LME0/DAMON  For advertising opportunities: contact@hogmedia.co  Support the show by becoming a member: https://www.youtube.com/channel/UCcs13VXhiObJg6jGDw2xbZg/join All Damon Bruce Plus content is available on your favorite podcast platform: https://pod.link/1681177856.  #49ers #NFLScheduleRelease #SanFrancisco49ers #NFLSchedule2026 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Maren Hamilton ran global social at The North Face — building and executing a strategy for 5.5 million followers, integrating athletes and creators, and navigating every platform shift from the follow graph to the discovery graph. Then she left to help build Popfly, the creator platform built specifically for the outdoor industry. In this conversation, Maren shares the playbook she developed at TNF for running brand social at scale, including how to say no to the hundreds of internal requests that flood every social team, why the outdoor buying journey is fundamentally different from fashion and beauty, and what brands still get wrong about TikTok, Threads, and Facebook. Plus: Why Head of Social to CMO is now a real career path, what makes a creator pitch actually land with a brand, and the Adidas sub-two-hour marathon moment that might be the greatest brand activation of the decade. Second Nature is supported by Popfly. If you want to support our podcast - and discover a platform that we believe is one of the best tools for connecting brands and creators, follow these links: Popfly for Creators/Athletes: https://popf.ly/secondnaturecreators Popfly for Brands: https://popf.ly/secondnaturebrands Show Notes:  Maren Hamilton: https://www.marenhamilton.com/ Popfly: https://popf.ly/secondnaturebrands TNF Instagram: https://www.instagram.com/thenorthface DBo on X: https://x.com/dylanbo TikTok: https://www.tiktok.com Gnara on TikTok: https://www.tiktok.com/@gnara_apparel?lang=en Taylor Hoekstra: https://www.linkedin.com/in/taylorhoekstra/ Popfly Storefront: https://app.popfly.com/@superridertv/storefront Alpaka: https://www.alpaka.com Camp Chef: https://www.campchef.com Backcountry: https://www.backcountry.com BPC - Brand, Product, Content: Halfdays x HOKA: https://www.halfdays.com/pages/hoka-x-halfdays Keen x 18 East: https://www.keenfootwear.com/collections/keen-x-eighteen-east Gnarly Nutrition x DBo: https://www.youtube.com/watch?v=qPtESorSIso Supercommunicators (Book): https://amzn.to/3RcJ7W6 Supercommunicators (Podcast Episode): https://open.spotify.com/episode/3jqbbLEHbZyEJ2kMqNskkz Adidas Pro Evo 3: https://www.adidas.com/us/adizero-adios-pro-evo-3-shoes/KH7678.html Join us on LinkedIn: https://www.linkedin.com/company/second-nature-media Meet us on Slack: https://www.launchpass.com/second-nature Follow us on Instagram: https://www.instagram.com/secondnature.media Subscribe to our newsletter: https://www.secondnature.media Subscribe to the YouTube channel: https://www.youtube.com/@secondnaturemedia

Full Show Broadcast. Buffalo Bills Greg Rousseau & Matthew Fairburn on the show. Gene reacts to the Sabres game 5 loss & the Bills 2026-27 schedule. Timmy has his take. Gene shares shots & last call.

Gene gets you all set for Sabres & Canadiens "pivotal game 5." Happy NFL Schedule Release Day. Gene has your leaks as he attempts to paste the entire Bills schedule together.

Gene has schedule leaks: The Buffalo Bill play week 1 in Houston. Plus other not officially announced games.

The 49ers are heading to Australia to open the season against the Rams on Thursday Night Football, and this matchup could set the tone for the 2026 season. Wayne Breezie breaks down the travel, pressure, playoff implications, and why this game means way more than people realize.

(00:48) Full 2026 NFL Schedule release - Thursday, 8pm (37:40) Cowboys will host Eagles on Thanksgiving (Week 13, 4:25PM, FOX) (41:37) SNF Opener: Cowboys at Giants, Sunday September 13 (48:30) MNF Opener: Broncos vs Chiefs, Monday September 14 (50:50) Bills open new stadium in Week 2 on TNF vs LionsSee omnystudio.com/listener for privacy information.

In this episode of Next in Media, Mike Shields sits down with Alan Moss, VP of Global Advertising Sales at Amazon Ads, to talk about Amazon's rapid transformation into a full-funnel advertising powerhouse. Alan walks through how he joined Amazon mid-COVID in 2020 and within a few years helped land an 11-year NFL deal, launch Prime Video ads, and close an NBA partnership that made Prime Video a year-round sports network.  He and Mike dig into what's working in the upfront market, why Amazon sees retail media and streaming as one unified full-funnel business, and how Amazon DSP's partnerships with Netflix, Disney, Roku, and others now reach 90% of household audiences. They also get into the growing role of Twitch and creators as a mid-funnel marketing lever, and why Alan believes the future is AI agents — not just for creative optimization, but for full campaign orchestration. Key Highlights

Matt Parrino, who covers the Bills for the Syracuse Post Standard & The Shout Podcasts stops in. The Bills will open New Highmark Stadium in week 2 vs the Detroit Lions on Thursday Night Football. Matt also dishes on Bills rookie mini camp, free agent signings, the latest news & the Sabres.

Full Show Broadcast features. Matt Parrino on the Buffalo Bills. Owen Parker from WGR-550 previews Sabres & Canadiens game 4 tonight in Montreal. Timmy shares his hot take, Gene has shots & last call is for you.

Gene starts the show off discussing the Sabres must win game 4 tonight in Montreal. Buffalo made some line-up changes. The Buffalo Bills will open New Highmark Stadium in week 2 vs the Detroit Lions on Thursday Night Football. How good are the Lions? Who will Buffalo play in week 1?

Tim Schneider shares his take of the day & Gene lines up shots.

Full Hour 1. Gene talks the Sabres & Canadiens game 4 tonight. Buffalo made some lineup changes. The Buffalo Bills open New Highmark stadium when they host the Detroit Lions in week 2 on Thursday Night Football. Matt Parrino stops in to go over the latest Bills news.

In this episode of The Jonathan Wier Show, Jonathan and co-host Cody Akins tackle the upcoming NFL schedule release (Thursday, May 14th at 7 PM CT) and debate which team they want the Chiefs to open against. Cody wants the Jets for an easy motivational win, but Jonathan argues for the Seahawks — repossess their banner on banner night and give Kenneth Walker his revenge game. The conversation pivots to a bigger problem: the NFL is becoming the world's biggest mall. With games now scattered across Netflix, Peacock, Prime, Paramount+, YouTube, and Netflix again, Jonathan argues the league is sacrificing its big-box-store accessibility for greed. He doesn't mind games on different days — but the fragmentation across paid services is going to cost them casual fans. The guys then debate the Star Fox 64 remake for Switch 2. Cody is genuinely excited (and hopeful it signals an Ocarina of Time remake for Zelda's 40th anniversary). Jonathan sees it as another nostalgia trap — Nintendo knows aging millennials will buy it no matter how much they complain, the same playbook George Lucas ran with the Star Wars Special Editions in the '90s. They close on tech policy: Utah trying to ban VPNs (unenforceable and ignores how cellular IPs work), and Meta rolling out AI age verification because kids are bypassing checks with mustaches, hats, haircuts, and makeup. Jonathan's takeaway — parents need to stop delegating parenting to the government. Talk to your kids. Block sites on your router. Do the work.

Rich and the guys react to the Oklahoma City Thunder's Game 1 win over the Lakers and weigh in on the NBA's ongoing flopping problem. ‘Thursday Night Football' Analyst Andrew Whitworth and Rich discuss the NFL's upcoming schedule release, why Cincinnati Bengals fans (and Joe Burrow) should be excited by the team's offseason moves, and the Rams drafting QB Ty Simpson despite having Matthew Stafford still playing at an MVP level. Rich reacts to a proposal by the American Football Coaches Association that would eliminate CFB conference championship games and more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Can you decrease inflammation naturally, without stopping medication?In this in-depth masterclass, Dr. Isabelle Amigues, double board-certified rheumatologist and metastatic breast cancer survivor, explains the science behind the nervous system and inflammation connection.You'll learn:• The relationship between the immune system and the autonomic nervous system• What the inflammatory reflex is• How vagus nerve stimulation lowers TNF, IL-6, and inflammatory cytokines• Why FDA-approved vagus nerve devices are changing autoimmune treatment• Practical, science-backed techniques to lower inflammation naturally• How breathing, cold exposure, and mindful movement activate the parasympathetic systemThis is not “instead of medication.”This is about expanding the toolbox.If you have rheumatoid arthritis, lupus, gout, or any inflammatory condition — this conversation will change how you think about healing.Hope, driven by science.

Sleep and weight gain are directly connected. Poor sleep disrupts hormones, raises blood sugar, tanks testosterone and estrogen, causes fatty liver, and wrecks your gut. If you've been doing everything right and the scale won't move, your sleep could be the missing link. FEATURED PRODUCT Chill by MSW Nutrition is a powdered drink mix formulated to support your body's natural calming chemistry — exactly what's needed when chronic stress and cortisol overload are stealing your sleep. Featuring GABA, L-Theanine, myo-Inositol, Taurine, and Magnesium, Chill helps balance neurotransmitters, quiet the nervous system, and promote the deep, restorative sleep your hormones, metabolism, and weight depend on — all five mechanisms discussed in this episode.

On today's show, Pat, Darius Butler, AJ Hawk and the boys recap WrestleMania 42 as Pat is showing the effects from Saturday night after being brutalized by Jelly Roll, Cody Rhodes, and Randy Orton. They also cover the NBA and NHL Playoffs in full swing, and the NFL Draft being just a few days away. They are also joined by several great guests including ESPN Senior NFL Insider Adam Schefter; former CMO and BMO of the NFL, and current CEO of the PGA Tour, Brian Rolapp; Super Bowl Champion, 4x Pro Bowler, 3x All-Pro, Walter Payton Man of the Year, and analyst for Thursday Night Football on Prime, Andrew Whitworth; 11 year NBA veteran, NBA Champion, and current NBA analyst on ESPN, Iman Shumpert; and lastly, former NFL team doctor, and host of the Sports Injury Central podcast, Dr. David Chao. Make sure to subscribe to youtube.com/thepatmcafeeshow or watch on ESPN (12-2 EDT), ESPN's Youtube (12-3 EDT), or ESPN+. We appreciate the hell out of all of you, We'll be off tomorrow, but we'll be LIVE from the Draft Spectacular set in Pittsburgh on Wednesday. Cheers. Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure. Four years cancer-free. Dave breaks down the mechanistic basis for oncolytic virotherapy—why cancer cells can't mount antiviral defenses that healthy tissue can—and the regulatory tension between patient autonomy and FDA gatekeeping on experimental immunotherapies. This is either a triumph of DIY biohacking or a cautionary tale about biosafety; either way, oncolytic virotherapy is accelerating toward mainstream clinical use and forcing a reckoning about access to cutting-edge cancer immunology. Sources: -https://www.dana-farber.org/newsroom/news-releases/2026/virus-based-therapy-boosts-anti-cancer-immune-responses-to-brain-cancer -https://www.eurekalert.org/news-releases/1116087 -https://acgtfoundation.org/news/oncolytic-virus-therapy-for-cancer/ ***Spermidine is the Missing Link Between Fasting and Longevity*** A Nature Cell Biology study across yeast, flies, mice, and humans reveals that fasting triggers longevity exclusively through spermidine—blocking spermidine synthesis ablates every lifespan-extending benefit, cardioprotection, and anti-inflammatory outcome, even with identical caloric restriction. Dave explains why your intermittent fasting protocol is metabolically inert without spermidine, the specific foods highest in bioavailable spermidine (wheat germ, aged cheddar, shiitake mushrooms, fermented foods), and how to time supplementation for maximum autophagy activation. This is the most critical missing variable in fasting-focused biohacking that almost no one is tracking. Sources: -https://www.nature.com/articles/s41556-024-01468-x -https://pubmed.ncbi.nlm.nih.gov/39117797/ -https://oxfordhealthspan.com/blogs/aging-well/spermidine-and-healthy-aging-insights-from-a-2026-nature-review -https://www.glp-1.science/blog/spermidine-autophagy-supplement/ ***Hair Regrowth Breakthrough: SHH-Mimetic Peptides Replace Minoxidil*** Topical peptides mimicking sonic hedgehog signaling (the embryonic pathway that initiates hair follicles) activate dermal papilla stem cells and deliver 65% hair regrowth at 24 weeks versus 40% with minoxidil—with zero systemic absorption and zero cardiovascular risk. Dave covers why minoxidil's vasodilation mechanism is crude (and why it triggers tachycardia and hypertrichosis), how SHH-mimetic peptides directly target the actual biological lever (stem cell activation), and why this mechanistic upgrade should reshape hair loss treatment within 12 months. This is precision medicine applied to cosmetic optimization. Sources: -https://finance.yahoo.com/sectors/healthcare/articles/goodbye-minoxidil-clean-bio-hacking-150800494.html ***"Sardinemaxxing": $1.39 Per Can Delivers 370% B12, 982mg Omega-3s, 96% Selenium*** Canned sardines are experiencing a viral surge on TikTok (#sardinemaxxing: 90,000+ videos) because a single 100-gram serving packs 370% daily B12, 982mg omega-3s, 96% selenium, and 24% vitamin D—all for $1.39. Dave breaks down the nutrient density to cost ratio (superior to wild salmon, fish oil supplements, and selenium stacks), the anti-inflammatory mechanisms (B12 methylation support, selenium-dependent glutathione peroxidase, omega-3 IL-6/TNF-α reduction), and why this represents a biohacker's efficiency play: maximum micronutrition per dollar with zero processing overhead. The shift from complexity back to simplicity. Sources: -https://news.northeastern.edu/2026/04/08/what-is-sardinemaxxing/ ***Fluoride in Community Water Has No Effect on IQ or Cognition — Wisconsin Longitudinal Study*** A seven-decade Wisconsin study tracking 10,317 people from age 16 through 80 finds zero evidence that community water fluoridation (0.7 mg/L, the U.S. recommended level) reduces IQ, impairs cognition, or causes neurotoxicity at any life stage. Dave distinguishes between community-level fluoridation and high-endemic-fluoride regions (2–10 mg/L in parts of Asia), clarifies why the anti-fluoridation narrative became culturally dominant without robust U.S. epidemiological data, and examines why 17+ states reversed fluoridation policy based on flawed evidence transfer. This is a case study in how folklore—even with mechanistic rationale—can override data. Individual choice about fluoride exposure remains valid; cognitive toxicity at community water levels is not supported. Sources: -https://www.sciencenews.org/article/fluoride-drinking-water-iq-no-evidence -https://www.nbcnews.com/health/kids-health/fluoride-water-children-iq-brain-cognition-study-rfk-jr-rcna267328 -https://studyfinds.com/major-study-finds-no-link-between-fluoride-water-lower-iq/ -https://medicalxpress.com/news/2026-04-fluoride-kids-iq-decades-analysis.html -https://jamanetwork.com/journals/jamapediatrics/fullarticle/2828425 -https://ntp.niehs.nih.gov/research/assessments/noncancer/completed/fluoride This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immunotherapy breakthroughs, fasting optimization, cosmetic stem cell activation, nutrient density efficiency, and evidence-based policy reversals. Host Dave Asprey connects emerging clinical research, decade-long epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and distinguishing mechanistic wins from folklore-driven narratives. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: oncolytic virus therapy cancer, measles VSV immunotherapy, DIY biohacking immunotherapy, regulatory gatekeeping cancer treatment, spermidine fasting autophagy, spermidine longevity, intermittent fasting mechanism, wheat germ aged cheddar spermidine, SHH sonic hedgehog hair growth, dermal stem cell activation hair, minoxidil replacement peptide, hair regrowth mechanism, sardinemaxxing TikTok, sardines omega-3 B12 selenium, nutrient density cost ratio, nutrient bioavailability supplements, fluoride IQ study Wisconsin, community water fluoridation safety, fluoride high-exposure risk, anti-fluoridation evidence, biohacking news 2026, longevity research, mechanism-driven biohacking, performance optimization, healthspan extension Thank you to our sponsors! - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. -iRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com/DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Virologist Self-Cures Cancer 02:41 – Fasting & Spermidine 04:22 – Hair Loss: Beyond Minoxidil 06:08 – Sardines as a Supplement Stack 07:43 – Fluoride & IQ: The 70-Year Study 09:47 – Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On this episode of The Jon Gordon Podcast, I sit down with Hall of Fame NFL athletic trainer and sports medicine expert Mike Ryan for an inspiring conversation that's filled with wisdom, stories from the NFL sidelines, and practical ways to stay healthy from his new book Foam Rolling made Easy.   Mike shares his unique journey—from his early days as an assistant with the New York Giants to becoming the youngest head athletic trainer in the NFL with the Jacksonville Jaguars, and later transitioning to his current role with NBC's Sunday Night Football. Along the way, Mike opens up about the leadership lessons he learned under pressure, the importance of clear communication, and the power of honesty in building trust with both players and coaches.   We delve into the mindset shifts required when stepping into a leadership role, the art of mentoring others to their own success, and the lasting impact of fostering a culture where team members can grow and thrive. Mike's commitment to making sports medicine simple and accessible shines through as he discusses his mission to help people move pain-free and live more active, fulfilling lives. He unpacks strategies for injury prevention, reveals how foam rolling can unlock your body's potential, and explains why taking care of ourselves matters—not just for elite athletes, but for anyone who wants to stay "stronger for longer."   Whether you're a leader, an athlete, or simply someone looking to invest in your health, this episode is packed with actionable advice and encouragement. Mike's passion is contagious, and his message is clear: no matter your age or where you're starting from, positive change and lifelong wellness are within your reach. About Mike, Mike Ryan is a sports medicine specialist, physical therapist and former 26-year National Football League (NFL) Head Athletic Trainer/Physical Therapist. He proudly served as President of the PFATS Research & Education Foundation for 14 years. Mike was recently inducted into the NFL Athletic Trainers Hall of Fame as a member of the Class of 2026. He's focused his career post-NFL career on teaching individuals the art of restoring pain-free joint movement without medicine. Mike's Personal Mission Statement is simple: To Enhance the Health of Others and Himself Mike is the currently the sideline Sports Medicine Analyst for both Sunday Night Football and Thursday Night Football. Mike's second book, Foam Rolling Made Easy, was released in January 2026. His athletic and extreme-sport resumes continue to grow: • Acrobatic plane Wing Walking • Competing in 3 of the last 4 three DekaFit World Championships • 6 Ironman triathlons in 5 countries • Great white shark diving in South Africa • Bungee jumping in New Zealand • Two Running with the Bulls in Spain • 2002 Duathlon World Championships • Ironman Triathlon World Championships Mr. Ryan attended Central Connecticut State University earning hisdegree in Athletic Training before earning hisPhysical Therapy degree from the University of Connecticut.  Here's a few additional resources for you… Do you feel called to share your story with the world? Check out Gordon Publishing  Follow me on Instagram: @JonGordon11 Check out my new revised release of my book, The Power of Positive Leadership here! Every week, I send out a free Positive Tip newsletter via email. It's advice for your life, work and team. You can sign up now here and catch up on past newsletters. Ready to lead with greater clarity, confidence, and purpose? The Certified Positive Leader Program is for anyone who wants to grow as a leader from the inside out. It's a self-paced experience built around my most impactful leadership principles with tools you can apply right away to improve your mindset, relationships, and results. You'll discover what it really means to lead with positivity… and how to do it every day. Learn more here! Do you feel called to do more? Would you like to impact more people as a leader, writer, speaker, coach and trainer? Get Jon Gordon Certified if you want to be mentored by me and my team to teach my proven frameworks principles, and programs for businesses, sports, education, healthcare!