DASON Digest

Episode Notes Join DASON Liaison Jeannette Bouchard as she hosts Dr. Dan Ilges and Dr. Ryan Stevens to discuss the recent article published in Infection Control & Hospital Epidemiology titled: “Real-world Utility of Procalcitonin in Patients Hospitalized with Community-Acquired Pneumonia: A Matched Cohort Study.” Together, they unpack how this study challenges the utility of procalcitonin in guiding antibiotic use for CAP, explores implications for diagnostic stewardship, and reflects on strategies to optimize antimicrobial decision-making in inpatient care. The articles reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40017121/ and here: https://www.fda.gov/media/100879/download For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson talks with Dr. Jason Trubiano, Director of Infectious Diseases at Austin Health in Australia. Drs. Johnson and Trubiano discuss an article in Journal of Infection entitled "Development and validation of a cephalosporin allergy clinical decision rule." The article can be found here: https://pubmed.ncbi.nlm.nih.gov/40288499/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Join DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard as she reviews the recent article published in Antimicrobial Stewardship & Healthcare Epidemiology titled: “(Re)Moving the Needle: A Retrospective, Quasi-Experimental Assessment of the Impact of a Treatment Guideline on Oral Antibiotic Prescribing for Orthopedic Infections." She discusses how this study highlights the real-world impact of guideline implementation on shifting antibiotic prescribing practices for bone and joint infections. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40160226/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode, DASON Clinical Pharmacist Liaison Dr. April Dyer talks with us about how a microbiology-driven electronic health record-algorithm and order set can decrease antipseudomonal use in diabetic foot infections. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40160223/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Angelina Davis chats with us about several articles about antibiotic prophylaxis for spontaneous bacterial peritonitis (SBP) in patients with cirrhosis. The materials reviewed in this episode can be found on the DASON Digest page on our website: https://dason.medicine.duke.edu/blog/sbp-prophylaxis-what-were-doing-why-were-doing-it-and-should-we-keep-doing-it For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join the Duke ID PGY2 resident Natalie Harris as she talks with Dr. Julie Gray about her new article published in ASHE this year titled “Short versus long treatment duration for streptococcal bloodstream infection." The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40026772/ for more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON liaison Jeannette Bouchard as she talks with Dr. Kati Shihadeh about her new article published in ASHE this year titled “Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-experimental study. The article reviewed in this episode can be found here: https://pmc.ncbi.nlm.nih.gov/articles/PMC11822621/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join Drs. Emily Stevenson and Jessie Seidelman as they discuss Dr. Seidelman's experience with blood culture stewardship and her recent publications as well as a new publication out of Virginia and their experience of their efforts during the shortage. Materials discussed today: Main article: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology/article/blood-culture-bottle-shortage-mitigation-efforts-analysis-of-impact-on-ordering-and-patient-impact/6E6B3256942821F7C7C4758739F79BC3 Other articles mentioned: https://www.sciencedirect.com/science/article/pii/S0196655324004723?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC11007355/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11758502/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson chats with Dr. Sunish Shah from University of Pittsburgh Medical Center about metronidazole dosing for bloodstream infections. The article reviewed in the episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39667533/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode DASON Clinical Pharmacist Liaison Dr. April Dyer talks with Dr. Rebekah Moehring talk to us about outcomes of antibiotic de-escalation in patients with suspected sepsis. The article discussed in the episode can be viewed here: https://pubmed.ncbi.nlm.nih.gov/39657050/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join Drs. Libby Dodds Ashley and Dev Anderson as they discuss one of the latest articles from the Duke ID team regarding C. difficile testing and the confusion that surrounds certain testing results. The articles reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39828613/ and https://pubmed.ncbi.nlm.nih.gov/39180325/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode of the DASON Digest Podcast, Dr. Angelina Davis, one of our DASON Clinical Pharmacist Liaisons, talks to us about the BALANCE Trial and the work the investigators did with duration of antibiotic treatment for bloodstream infections in hospitalized patients. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39565030/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join Dr. Jeannette Bouchard and DiRTE Lab Director Bobby Warren to discuss a fun BMJ article from their end of the year edition titled Bug in a Mug: Are Hospital Coffee Machines Transmitting Pathogens. We hope everyone has a happy New Year! The article reviewed in today's episode can be found here: https://www.bmj.com/content/383/bmj.p2564 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson talks with Dr. Dan Morgan from University of Maryland School of Medicine. The articles and documents reviewed can be found here: https://www.cdc.gov/patient-safety/hcp/hospital-dx-excellence/index.html https://www.cdc.gov/patient-safety/media/pdfs/DxEx-Tool-Priority-Examples-508.pdf https://www.cdc.gov/patient-safety/media/pdfs/DxEx-Tool-Additional-Examples-508.pdf https://www.cdc.gov/patient-safety/media/pdfs/DxEx-Tool-Medical-Test-Checklist-508.pdf https://pubmed.ncbi.nlm.nih.gov/36786646/ https://pubmed.ncbi.nlm.nih.gov/39602334/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this very special episode we have guest appearances from old and new stewardship friends. References for this episode can be found at this link: https://dason.medicine.duke.edu/blog/episode-100-celebration-stewardship For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes For this episode, Dr. Libby Dodds Ashley is joined by Dr. Chris Hostler to discuss Dr. Hostler's recent article evaluating postoperative outcomes in patients receiving ertapenem for colon surgery. This article that includes some data from our DASON sites so this is a MUST listen! The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39363596/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Join Dr. Angelina Davis as she discusses a recent article in Clinical Infectious Diseases on differences in outpatient community-acquired pneumonia treatment regimens. the article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39442057/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson reviews an article that compares the efficacy and safety of intravenous (IV) versus oral (PO) stepdown therapy for uncomplicated streptococcal bacteremia. The article can be found here: https://academic.oup.com/ofid/article/11/7/ofae361/7701251 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Dr. Jeannette Bouchard and guest Dr. Emily Heil walk listeners through key updates to the IDSA Resistant Gram-negative Guidance and what may be most pertinent for our community partners. The materials reviewed today can be found here: https://www.idsociety.org/practice-guideline/amr-guidance/#UpdateHistory For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Dr. April Dyer discusses a recent article in Antimicrobial Stewardship and Hospital Epidemiology on how pharmacists can help with post-hospital discharge micro result review. The article reviewed in today's episode can be found here: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology/article/impact-of-pharmacistled-microbiology-result-followup-postdischarge-for-patients-undergoing-inpatient-infectious-diseases-consultation/ED155B2C10D145480228E715ABCFB000 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Clinical Pharmacist Dr. Libby Dodds Ashley as she discusses a recent article in Pharmacotherapy on daptomycin dosing with one of the primary authors, Dr. Katie Olney. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39078247/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this exciting episode, DASON Clinical Pharmacist Dr. April Dyer discusses a hot off the press article that follows up the results from the big PALACE trial that was published in 2023. The article reviewed in this episode can be found here: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822413 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this exciting episode, Dr. Jeannette Bouchard is joined by Drs. Katie Lambert and Catessa Howard to discuss their newly published brief report in OFID that helps shine a light on a common clinical issue, is cefazolin or ceftriaxone a better surrogate for third generation oral cephalosporins. The article reviewed in this episode can be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245689/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. April Dyer walks us through an article from Clinical Infectious Diseases entitled "Beyond Infection: Mortality and End-of-Life Care Associated with Infectious Disease Consultation in an Academic Health System." The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/38867715/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this exciting episode, Drs. Libby Dodds Ashley and Jeannette Bouchard are joined by Dr. Jason Roberts to discuss his two newly published articles in JAMA that help to answer the question: is there a difference between continuous and intermittent infusions of beta-lactam antibiotics, especially in the critically ill populations? The reviewed materials can be found here: https://dason.medicine.duke.edu/blog/it-goes-and-and-reviewing-new-rct-continuous-infusion-vs-intermittent-infusion-beta-lactams For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Angelina Davis talks to us about the use of AI in the management of bloodstream infections. The article reviewed can be found here: https://academic.oup.com/cid/article-abstract/78/4/825/7308526

Episode Notes In this episode, Dr. Jeannette Bouchard discusses a newly published article in JAMA about the use of piperacillin-tazobactam and cefepime in sepsis. This episode also ties into a previous episode (#74) and we would recommend listening to both episodes! The article reviewed in this episode can be found here: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2818278 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, University of Kentucky Infectious Diseases Pharmacy Residents, Will Harris and Tyler Pitcock, review a recently published article evaluating the impact of the implementation of rapid blood culture identification technology and stewardship intervention on treatment of blood cultures contaminated with coagulase-negative staphylococci. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/article/10/8/ofad416/7233915 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, University of Kentucky PGY2 Infectious Diseases Pharmacy Residents, Will Harris and Tyler Pitcock, discuss the recently published article evaluating the efficacy of the clinical decision tool, PEN-FAST, in de-labeling patients with reported penicillin allergies with one of the authors and Duke University Hospital Infectious Diseases Physicians, Dr. Nick Turner. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37459086/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Duke University Hospital Infectious Diseases Pharmacist Dr. Rebekah Wrenn and her resident, Amy Mackowiak, review Dr. Wrenn's recently published article evaluating the impact of default duration elimination on exposure to fluoroquinolone therapy.  The article reviewed in today's episode can be found here: https://pubmed.ncbi.nlm.nih.gov/38347810/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest Podcast, one of our DASON Clinical Pharmacist Liaisons, Dr. Melissa Johnson, talks with Dr. Jim Lewis, ID Clinical Pharmacy Coordinator and Adjunct Associate Professor at Oregon Health & Science University Departments of Pharmacy and ID in Portland, Oregon. The material reviewed in today's podcast can be found here: https://clsi.org/standards/products/microbiology/documents/m100/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. April Dyer talks to us about how to incorporate adverse event feedback into antibiotic stewardship. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/38415083/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode, DASON Clinical Pharmacist Liaisons Drs. Jeannette Bouchard and Libby Dodds-Ashley walk us through the details of a recent article published in ASHE to assess the impact of a clinical decision support survey to improve GI Panel ordering appropriateness at a VA. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/38415090/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Angelina Davis talks to us about the use of active versus passive methods of responding to rapid diagnostic blood culture results. The article reviewed can be found here: https://pubmed.ncbi.nlm.nih.gov/36483427/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard is joined by Dr. Kevin Garey, an adjunct professor at the University of Texas School of Public Health and senior author of the reviewed article. They walk us through the details of the microbiome effects oral omadacycline has versus oral vancomycin and what this might mean for the future of the treatment for C. difficile infections. The materials reviewed in today's episode can be found here: https://pubmed.ncbi.nlm.nih.gov/38051631/ and https://pubmed.ncbi.nlm.nih.gov/22563022/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaisons Drs. Melissa Johnson and Jeannette Bouchard discuss an article from ASHE on high-dose oral beta-lactam definitive therapy compared to fluoroquinolone or trimethoprim-sulfamethoxazole oral therapy for bacteremia secondary to a urinary tract infection. The article reviewed can be found here: https://pubmed.ncbi.nlm.nih.gov/37771747/ For more information about DSAON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Dr. April Dyer, one of our DASON Clinical Pharmacist Liaisons, talks to us about source specific order sets leading to improved empiric therapy in the ED in a 200 bed hospital. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad677/7491622# To learn more about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode, Drs. Bouchard, Dodds Ashley, and Perez review a large study tackling inappropriate antimicrobial use in the outpatient setting. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad585/7439469 For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode, Drs. Libby Dodds Ashley and Jeannette Bouchard, two of our DASON Clinical Pharmacists, talk to us about bringing and end to VAP. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37888914/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes This week we would like to use the feed to share a great episode of Sara Dong's podcast "Febrile."  Members of our DASON team and the Society for Healthcare Epidemiology of America's antimicrobial stewardship committee celebrate antibiotic awareness week by discussing stewardship teams and an example case.

Episode Notes In this episode, Dr. April Dyer, one of the DASON Clinical Pharmacists, talks about cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37837651/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes Drs. Perez, Hillenbrand and Mourad do a deep dive on how to best apply one of our most common stewardship tools. The article reviewed in this episode can be found here: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad467/7240295 For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode of the DASON Digest Podcast, DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard talks to us about clinical risk scores to improve empiric antimicrobial selection for outpatient complicated urinary tract infections. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/article/10/8/ofad319/7198038#413122181 For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode, Dr. Rey Perez chats with Drs. Rebekah Moehring and Libby Dodds Ashley about work done by the University of Pittsburgh using a weighted lottery to equitably allocate scarce supply of COVID-19 monoclonal antibody to patients. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37656472/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode of the DASON Digest Podcast, DASON Clinical Pharmacist Liaison Dr. Angelina Davis talks to us about the early discontinuation of antibiotics in patients admitted with clinically suspected serious infection but negative cultures. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37449298/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode of the DASON Digest Podcast, DASON Clinical Pharmacist Liaison Dr. April Dyer talks to us about improving the efficiency of antimicrobial stewardship action in acute care facilities. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad412/7234482 For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes Dr. Rey Perez chats with our newest DASON Clinical Pharmacist Liaison, Dr. Jeannette Bouchard, about the epidemiology of gram negative blood stream infections. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/article/10/7/ofad265/7175984 For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes Dr. Melissa Johnson from DASON talks to us about removing incorrect penicillin allergy labels. There are lots of supplemental materials for this episode, and they can all be viewed on the episode's page on our website: https://dason.medicine.duke.edu/blog/rx-success-tackling-penicillin-allergy-de-labelling-our-hospitals The main article discussed today is: https://pubmed.ncbi.nlm.nih.gov/37354996/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Dr. Angelina Davis talks to us about the use of clindamycin + vancomycin vs. linezolid for the treatment of necrotizing soft tissue infections. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37351452/ For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes For this episode, Drs. Libby Dodds Ashley and Rey Perez talk about probiotic-associated central venous catheter blood stream infections. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/37260310/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Infectious Diseases fellow Dr. Rey Perez chats with DCASIP Executive Director Dr. Dev Anderson about the latest surgical site infection compendium updates. The article reviewed can be found here: https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/strategies-to-prevent-surgical-site-infections-in-acutecare-hospitals-2022-update/2F824B9ADD6066B29F89C8A2A127A9DC To learn more about DASON, please visit: https://dason.medicine.duke.edu/